dihydrobenzoxathiin and Osteoporosis

dihydrobenzoxathiin has been researched along with Osteoporosis* in 1 studies

Other Studies

1 other study(ies) available for dihydrobenzoxathiin and Osteoporosis

Article	Year
Estrogen receptor ligands. 12. Synthesis of the major metabolites of an ERalpha-selective, dihydrobenzoxathiin antagonist for osteoporosis. Organic letters, 2005, Feb-03, Volume: 7, Issue:3 [reaction: see text] During the course of drug metabolism studies, a major metabolite of compound 1 was detected in rhesus monkeys and assigned structure 4. The intriguing biotransformation of 1 leading to 4 was confirmed by a 19-step total synthesis starting from resorcinol (11), the key feature of which was the construction of the oxygen bridge utilizing a phenolic oxidation and trapping sequence. In addition, the synthesis of a related metabolite (5) is described. Topics: Animals; Biotransformation; Estrogen Receptor alpha; Macaca mulatta; Models, Molecular; Molecular Conformation; Osteoporosis; Oxathiins; Oxidation-Reduction; Oxygen; Resorcinols; Selective Estrogen Receptor Modulators	2005

Article

Year

Estrogen receptor ligands. 12. Synthesis of the major metabolites of an ERalpha-selective, dihydrobenzoxathiin antagonist for osteoporosis.

Organic letters, 2005, Feb-03, Volume: 7, Issue:3

[reaction: see text] During the course of drug metabolism studies, a major metabolite of compound 1 was detected in rhesus monkeys and assigned structure 4. The intriguing biotransformation of 1 leading to 4 was confirmed by a 19-step total synthesis starting from resorcinol (11), the key feature of which was the construction of the oxygen bridge utilizing a phenolic oxidation and trapping sequence. In addition, the synthesis of a related metabolite (5) is described.

Topics: Animals; Biotransformation; Estrogen Receptor alpha; Macaca mulatta; Models, Molecular; Molecular Conformation; Osteoporosis; Oxathiins; Oxidation-Reduction; Oxygen; Resorcinols; Selective Estrogen Receptor Modulators

2005