dihydroactinidiolide has been researched along with Hemolysis* in 1 studies
1 other study(ies) available for dihydroactinidiolide and Hemolysis
| Article | Year |
|---|---|
Dihydroactinidiolide, a natural product against Aβ
Synthesis of natural products has speeded up drug discovery process by minimizing the time for their purification from natural source. Several diseases like Alzheimer's disease (AD) demand exploring multi targeted drug candidates, and for the first time we report the multi AD target inhibitory potential of synthesized dihydroactinidiolide (DA). Though the activity of DA in several solvent extracts have been proved to possess free radical scavenging, anti bacterial and anti cancer activities, its neuroprotective efficacy has not been evidenced yet. Hence DA was successfully synthesized from β-ionone using facile two-step oxidation method. It showed potent acetylcholinesterase (AChE) inhibition with half maximal inhibitory concentration (IC Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Benzofurans; Catalytic Domain; Cell Line, Tumor; Cholinesterase Inhibitors; Free Radical Scavengers; Hemolysis; Humans; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Neuroprotective Agents; Peptide Fragments; Protein Multimerization; Reactive Oxygen Species | 2018 |