dihydro-n-caffeoyltyramine and Hemolysis

Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N-feruloyloctopamine (2), trans-N -caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 microg ml(-1) and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 microg ml(-1). All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

Topics: Amides; Antifungal Agents; Biotechnology; Caffeic Acids; Candida albicans; Coumaric Acids; Erythrocytes; Hemolysis; Humans; Lycium; Magnetic Resonance Spectroscopy; Models, Chemical; Octopamine; Plant Bark; Plant Extracts; Saccharomyces cerevisiae; Trichosporon; Tyramine