digoxin and Substance-Related-Disorders

Heart failure is a costly and difficult disease to treat. However, new metrics make it an imperative to keep these patients out of the hospital. Implementing and maintaining patients on successful treatment plans is difficult. A multitude of factors make transitioning care to the outpatient setting difficult. A careful and well-orchestrated team of cardiologists, general practitioners, nurses, and ancillary support staff can make an important difference to patient care. A strong body of literature supports the use of pharmacologic therapy, and evidence-based therapies can improve mortality and quality of life, and reduce hospital admissions. Adjunctive therapies can be equally important.

Topics: Adaptation, Psychological; Adrenergic beta-Antagonists; Alcohol Drinking; Ambulatory Care; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiac Resynchronization Therapy; Cardiotonic Agents; Continuity of Patient Care; Defibrillators, Implantable; Deinstitutionalization; Diet; Digoxin; Diuretics; Drug Combinations; Exercise Therapy; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Mineralocorticoid Receptor Antagonists; Palliative Care; Risk Reduction Behavior; Secondary Prevention; Self Care; Smoking Cessation; Substance-Related Disorders

In a case where a 32-year-old man lost control of his vehicle, urine and blood samples were taken 6 h after the crash for toxicological investigations. In the hospital, the driver admitted consumption of some drugs, in particular digoxin and midazolam just before the crash which corresponded to the results of blood analyses. Toxicological findings indicated the presence of digoxin at 12.9 ng/ml and midazolam at 7 ng/ml in the blood. These results suggested that at the moment of the crash digoxin and midazolam blood levels were in the range of toxic and therapeutic concentrations, respectively. Therefore the respective roles of the drugs in the impairment of the ability to drive at the moment of the crash is discussed.

Topics: Accidents, Traffic; Adult; Alcohol Drinking; Autopsy; Cardiotonic Agents; Digoxin; Humans; Hypnotics and Sedatives; Male; Midazolam; Substance-Related Disorders

Topics: Alcoholism; Animals; Cardenolides; Digoxin; Enzyme Inhibitors; Ethanol; Male; Rats; Rats, Wistar; Saponins; Sodium-Potassium-Exchanging ATPase; Substance-Related Disorders

Since 1965, Health and Welfare Canada has operated an adverse drug reaction (ADR) program. The program accepts spontaneous reports of adverse drug reactions, and maintains an ADR database. The purpose of this article is to summarize the Psychiatric ADRs reported to this database since 1965. The nature of the information prohibits its use in the evaluation of epidemiological hypotheses about the etiology of drug-induced mental disorders. However, in an exploratory sense, the contents of the database may contribute to the development of epidemiological hypotheses about the etiology of drug-induced mental disorders. Of particular interest are areas of apparent contradiction between the contents of the database and the clinical literature.. The database was searched for reports of ADRs to a group of drugs which have been frequently implicated in causing psychiatric toxicity. All reports characterized as "psychiatric disorders" were down-loaded from the database for the analysis (n = 1822). The reports were further classified into nine categories according to the type of psychiatric symptoms described.. There were several reports of hallucinations caused by methyldopa, and also several reports of benzodiazepine-induced hallucinations and encephalopathy. These reactions have not been described in the literature. Also, there were few reports of digoxin-induced organic depression, and an absence of reports of organic mania induced by H-2 blockers, despite descriptions of these sorts of reactions in the clinical literature.. Further research is needed to define the neuropsychiatric toxicity associated with medical drugs. Clinicians must continue to consider the potential role of medications in the etiology of psychiatric symptoms.

Topics: Adverse Drug Reaction Reporting Systems; Benzodiazepines; Canada; Databases, Factual; Delirium; Digoxin; Hallucinations; Histamine Agonists; Humans; Methyldopa; Mood Disorders; Substance-Related Disorders

Topics: Adult; Digoxin; Electrocardiography; Humans; Male; Substance-Related Disorders; Suicide, Attempted

A case of massive digoxin ingestion with multiple arrhythmias, consisting of high grade A-V block and ventricular ectopy not responsive to lidocaine, is described. The arrhythmias ceased following administration of digoxin-specific Fab fragments. The patient improved and was transferred to the psychiatric unit.

Topics: Antibodies; Digoxin; Female; Humans; Immunoglobulin Fab Fragments; Immunotherapy; Middle Aged; Poisoning; Substance-Related Disorders

Topics: Aged; Digoxin; Humans; Male; Substance-Related Disorders

Topics: Brain; Digoxin; Electroencephalography; Epilepsy; Female; Humans; Middle Aged; Substance-Related Disorders

Topics: Aged; Antidepressive Agents; Antihypertensive Agents; Digoxin; Drug Prescriptions; Female; Humans; Hypnotics and Sedatives; Levodopa; Male; Pharmaceutical Preparations; Physician's Role; Substance-Related Disorders; Tranquilizing Agents

Topics: Adult; Age Factors; Aminoglycosides; Anti-Bacterial Agents; Carbenicillin; Diabetes Complications; Digoxin; Drug Hypersensitivity; Drug Therapy, Combination; Endocarditis, Bacterial; Gentamicins; Heart Failure; Humans; Kanamycin; Male; Neurologic Manifestations; Penicillin Resistance; Penicillins; Pseudomonas aeruginosa; Pseudomonas Infections; Sex Factors; Substance-Related Disorders

Topics: Animals; Cardiac Catheterization; Digoxin; Dogs; Heart Failure; Heart Valve Diseases; Heart Valve Prosthesis; Heroin; Humans; Injections, Intravenous; Male; Postoperative Complications; Pseudomonas Infections; Self Medication; Staphylococcal Infections; Substance-Related Disorders; Tricuspid Valve; Tricuspid Valve Insufficiency; Venous Pressure

Topics: Czechoslovakia; Digoxin; Drug Prescriptions; Electronic Data Processing; Humans; Hydrochlorothiazide; Lanatosides; Medical Records; Meprobamate; Nitroglycerin; Plants, Medicinal; Prenylamine; Rauwolfia; Substance-Related Disorders

Topics: Adult; Diagnosis, Differential; Digitalis Glycosides; Digoxin; Electrocardiography; Endocarditis, Subacute Bacterial; Female; Humans; Hypercalcemia; Hyperkalemia; Prednisone; Rheumatic Heart Disease; Substance-Related Disorders

Topics: Administration, Oral; Animals; Catheterization; Digitoxin; Digoxin; Feces; Fistula; Humans; Lymph; Male; Rats; Rats, Inbred Strains; Substance-Related Disorders; Thoracic Duct; Tritium

Topics: Aminophylline; Aspirin; Atropine; Cardiomyopathies; Cataract; Child, Preschool; Chloramphenicol; Chlorothiazide; Conjunctivitis; Digoxin; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Iatrogenic Disease; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Ophthalmic Solutions; Pre-Eclampsia; Pregnancy; Purpura, Thrombocytopenic; Substance-Related Disorders; Suppositories