digoxin and Shock

Anti-arrhytmic activity of cordarone was studied in 68 patients with circulatory failure (CF) and heart rhythm disorders with the aid of the 48-hour monitoring of the ECG. Cordarone was administered after the maintenance therapy with digoxin (the mean concentration of digoxin in the plasma 1.38 +/- 0.09 ng/ml) at an average dose of 300 mg/day. Cordarone suppressed supraventricular premature heart beat by 80.2%, ventricular premature heart beat (VPHB) by 76.4%, group VPHB by 82.9% and runnings of ventricular tachycardia by 86.6%. Antiarrhythmic activity of cordarone was more remarkable at the early stages of CF. The concentration of digoxin in the plasma did not exceed the mean therapeutic one. Therefore, cordarone possesses a high antiarrhythmic activity, with its efficacy being significantly higher in patients with moderately pronounced CF. At the same time cordarone influences to a less measure the quality of ventricular rhythm disorders in patients with severe CF and apparently does not avert the cases of sudden death in such patients.

Topics: Adolescent; Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Digoxin; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Shock

Topics: Acute Disease; Adult; Blood Pressure; Digoxin; Heart Failure; Humans; Shock

Topics: Aged; Cardiac Glycosides; Digoxin; Electrocardiography; Heart Diseases; Humans; Intensive Care Units; Male; Postoperative Complications; Pulmonary Embolism; Resuscitation; Shock; Surgical Procedures, Operative

Topics: Acidosis; Bicarbonates; Blood Pressure; Cardiac Output; Digoxin; Fructose; Humans; Hypoxia; Myocardial Infarction; Oxygen; Plasma Substitutes; Shock; Tromethamine

Topics: Blood Pressure; Cardiac Glycosides; Cardiac Output; Digoxin; Heart Failure; Heart Function Tests; Hemodynamics; Humans; Infusions, Parenteral; Lanatosides; Male; Middle Aged; Ouabain; Shock; Vascular Resistance; Vasoconstrictor Agents

Topics: Adrenal Cortex Hormones; Aged; Diabetes Complications; Digoxin; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Nitroglycerin; Shock; Vasodilator Agents

Topics: Angina Pectoris; Coronary Disease; Digoxin; Electrocardiography; Hydrochlorothiazide; Hypercholesterolemia; Hypertension; Metaraminol; Nitroglycerin; Shock; Shock, Cardiogenic; Vasopressins; Warfarin

Topics: Blood Pressure; Child; Digitalis Glycosides; Digitoxin; Digoxin; Diuretics; Drug Therapy; Fluid Therapy; Heart Auscultation; Heart Defects, Congenital; Heart Failure; Humans; Infant; Lanatosides; Liver Circulation; Morphine; Oxygen Inhalation Therapy; Parenteral Nutrition; Posture; Respiratory Tract Infections; Rest; Shock; Sodium; Water-Electrolyte Balance