digoxin and Pulmonary-Embolism

Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Digitalis Glycosides; Digoxin; Fever; Heart Atria; Heart Block; Humans; Hypotension; Lung Diseases, Obstructive; Methoxamine; Pacemaker, Artificial; Procainamide; Propranolol; Pulmonary Embolism; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Ventricular Fibrillation

Topics: Anemia, Macrocytic; Anti-Arrhythmia Agents; Anticoagulants; Azathioprine; Chemical and Drug Induced Liver Injury; Cholelithiasis; Clofibrate; Colitis, Ulcerative; Dextrans; Digoxin; Drug Therapy; Fibrinolytic Agents; Halothane; Heparin; Hepatitis B Antigens; Humans; Hyperthyroidism; Iodine Isotopes; Leukemia; Myocardial Infarction; Platelet Adhesiveness; Pulmonary Embolism; Thrombosis; Venoms

Despite wide usage of digoxin for various diseases in cardiology practice, its benefit is controversial and moreover it had been associated with unfavorable outcomes in some previous studies. The aim of this present study was to demonstrate whether digoxin usage was related with worse outcomes or not in patients with acute pulmonary embolisms.. A total number of 1215 patients retrospectively enrolled for the study. Basic demographic features, pulmonary embolism severity index (PESI) scores, laboratory parameters and medications of patients who had been diagnosed with acute pulmonary embolism were recorded. Short (30 days) and long-term mortality were reported as the clinical outcomes.. Total mortality was 15.4% in the study population and 78 of these subjects died within the first 30 days. The frequency of digoxin treatment was 8% and most of these patients were prior users. According to the binary logistic regression analyses the PESI score, right ventricle (RV) diastolic diameter, systolic pulmonary arterial pressure (sPAP), brain natriuretic peptide (BNP), troponin and digoxin therapy (odds ratio, OR: 2.82 95% confidence interval, CI: 1.39-8.31, P = 0.03) were found as independent predictors of short-term mortality. Beside these findings; sPAP, PESI score, RV diastolic diameter and digoxin therapy (hazard ratio, HR: 2.11 95%CI: 1.22-7.31, P = 0.03) were determined as independent predictors of long-term mortality in Cox regression analyses. In subgroup analysis, we determined significantly greater increase in short-term mortality with use of digoxin among patients who had chronic renal disease, among patients under thrombolytic therapy and under high dosage of digoxin therapy and among female patients.. Digoxin has been used extensively for decades in the treatment of heart failure and arrhythmias despite some controversies over its benefit. For the first time in the literature, we have demonstrated independent association of digoxin therapy with short-term and long-term mortality in patients with acute pulmonary embolism.

Topics: Acute Disease; Digoxin; Female; Humans; Male; Pulmonary Embolism; Retrospective Studies; Risk Assessment; Severity of Illness Index

Topics: Aged; Blood Pressure; Carcinoma, Hepatocellular; Cardiotonic Agents; Digoxin; Fatal Outcome; Heart Failure; Humans; Liver Neoplasms; Male; Pulmonary Embolism; Renal Insufficiency, Chronic; Systole

Tricuspid atresia is one of the rarest heart defects, and it is rarely associated with prolonged survival. This paper describes the third known case of pregnancy associated with tricuspid atresia. This is the first detailed report of the clinical course of a patient with this disorder. Complications included heart failure, multiple pulmonary emboli, cerebral embolization, and premature labor. Recommendations are made regarding patient care.

Topics: Adult; Blood Gas Analysis; Digoxin; Electrocardiography; Female; Furosemide; Heart Septal Defects; Heparin; Humans; Pregnancy; Pregnancy Complications, Cardiovascular; Pulmonary Embolism; Tricuspid Valve

Topics: Adult; Age Factors; Aged; Death, Sudden; Digoxin; Diuretics; Female; Graves Disease; Heart Failure; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Middle Aged; Postoperative Complications; Prognosis; Pulmonary Embolism; Sex Factors; Tachycardia; Thyroid Crisis

Topics: Angiography; Cardiac Catheterization; Digoxin; Female; Heparin; Humans; Lung; Middle Aged; Obesity; Obesity Hypoventilation Syndrome; Pulmonary Embolism; Respiratory Function Tests

Topics: Aged; Cardiac Glycosides; Digoxin; Electrocardiography; Heart Diseases; Humans; Intensive Care Units; Male; Postoperative Complications; Pulmonary Embolism; Resuscitation; Shock; Surgical Procedures, Operative

Topics: Blood Gas Analysis; Blood Pressure; Cardiac Catheterization; Chronic Disease; Diagnosis, Differential; Digoxin; Electrocardiography; Female; Heart Failure; Heparin; Humans; Hypertension, Pulmonary; Middle Aged; Pulmonary Circulation; Pulmonary Embolism; Radiography; Radionuclide Imaging; Recurrence; Tetracycline; Thrombosis

Topics: Angiography; Chest Pain; Digoxin; Drug Therapy; Dyspnea; Humans; Pain; Pathology; Prednisone; Pulmonary Embolism; Pulmonary Heart Disease; Radiography, Thoracic