digoxin and Marfan-Syndrome

Thoracic aortic aneurysms (TAA) in Marfan syndrome, caused by fibrillin-1 mutations, are characterized by elevated cytokines and fragmentated elastic laminae in the aortic wall. This study explored whether and how specific fibrillin-1-regulated miRNAs mediate inflammatory cytokine expression and elastic laminae degradation in TAA. miRNA expression profiling at early and late TAA stages using a severe Marfan mouse model (Fbn1

Topics: Animals; Aortic Aneurysm, Thoracic; Cytokines; Digoxin; Disease Models, Animal; Fibrillin-1; Humans; Hypoxia; Marfan Syndrome; Matrix Metalloproteinase 12; MicroRNAs

Clinical autopsy rate have been declining since the 1950s, but it remains a useful investigation tool.. Through six examples of our experience, we underline its interest for clinical, didactic and public health purposes.. We try to understand the reasons for its decline and, as demonstrated, it can be attributed to a number of factors. These need to be addressed in order to reassert the status of the autopsy as an investigation and audit tool which is crucial to the future effectiveness of modern medicine.

Topics: Adult; Aged; Atherosclerosis; Atrial Fibrillation; Autopsy; Cardiotonic Agents; Casuistry; Cause of Death; Coronary Artery Disease; Coronary Thrombosis; Diagnosis, Differential; Digoxin; Education, Medical; Female; France; Hallucinations; Hospitals, University; Humans; Male; Marfan Syndrome; Meningitis, Listeria; Meningitis, Pneumococcal; Middle Aged; Myocardial Infarction

Topics: Adult; Anthropometry; Cardiomegaly; Digoxin; Furosemide; Humans; Male; Marfan Syndrome

Topics: Digoxin; Furosemide; Heart Failure; Humans; Infant; Male; Marfan Syndrome