digoxin and Lymphoma

Topics: Analgesics; Anti-Bacterial Agents; Anticoagulants; Asthma; Blood Transfusion; Contraceptives, Oral; Digoxin; Drug Interactions; Drug Therapy; Humans; Infusions, Parenteral; Leukemia; Lymphoma; Prostaglandins

An 8-year-old girl who was recently diagnosed as having anaplastic large-cell lymphoma presented with atrial tachycardia and dilated cardiomyopathy, which is a contraindication for further treatment with cardio-toxic chemotherapy. After starting digoxin therapy, the dilated cardiomyopathy resolved. Repeated episodes of atrial tachycardia in this case were not caused by any common disorder but were due to mechanical stimulation by a central venous catheter. Central venous catheters are known to cause mainly ventricular arrhythmias. However, atrial tachycardia is a rare manifestation of arrhythmia due to mechanical stimulation of the heart by a central venous catheter, with potentially important cardiovascular consequences.

Topics: Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Catheterization, Central Venous; Child; Digoxin; Echocardiography; Electrocardiography; Female; Humans; Lymphoma; Tachycardia, Ectopic Atrial

Topics: Adult; Aged; Anti-Glomerular Basement Membrane Disease; Digoxin; Female; Glomerulonephritis; Humans; Hypertension, Malignant; Lupus Vulgaris; Lymphoma; Male; Middle Aged; Multiple Myeloma; Nephrotic Syndrome; Plasma Exchange; Plasmapheresis; Purpura, Thrombocytopenic; Vasculitis; Waldenstrom Macroglobulinemia

Mucosal defects decrease digoxin absorption in patients with malabsorption syndromes. Since the intestinal mucosa can be damaged by cytostatic drugs, we investigated their effects on digoxin plasma levels and urinary digoxin excretion. In six patients with malignant lymphoma who received 0.8 mg beta-acetyldigoxin before and 24 hr after treatment with a combination of cyclophosphamide, oncovin, procarbazine, and prednisone (COPP) or cyclophosphamide, oncovin, and prednisone (COP), plasma digoxin concentrations were measured 0 to 8 hr after the dose and areas under the plasma concentration-time curves were calculated. In 15 patients on 0.3 mg of beta-acetyldigoxin daily, plasma glycoside concentrations and renal excretion were measured daily before and after COPP, COP, cyclophosphamide, oncovin, cytosine-arabinosine, and prednisone (COAP), or adriamycin, bleomycin, and prednisone (ABP) treatment schemes. The diminished steady-state glycoside plasma concentrations and daily renal glycoside excretion during the 24 to 168 hr after the cytostatic drug established reversible impairment of digoxin absorption. The delayed time to peak after a single dose of digoxin during cytostatic drug therapy shows that extent and rate of digoxin absorption are reduced. To maintain adequate control of digoxin therapy in patients treated with cytostatic drugs, plasma levels should be monitored.

Topics: Acetyldigoxins; Adult; Aged; Antineoplastic Agents; Digoxin; Drug Interactions; Female; Humans; Intestinal Absorption; Kinetics; Lymphoma; Male; Middle Aged; Xylose

Topics: Antineoplastic Agents; Digoxin; Drug Interactions; Humans; Intestinal Absorption; Lymphoma; Malabsorption Syndromes; Time Factors

Topics: Adult; Cardiomegaly; Digoxin; Doxorubicin; Electrocardiography; Female; Heart; Heart Diseases; Heart Failure; Heart Function Tests; Heart Ventricles; Humans; Lymphoma; Male; Middle Aged; Multiple Myeloma; Neoplasms; Prospective Studies

A 56-year-old male patient diagnosed as a case of procainamide-induced systemic lupus erythematosus (SLE) was found to have a lymphoproliferative disorder at postmortem examination.Contrary to other immune disorders, the association of SLE with neoplasia is a rare occurrence. The present case raises the question of whether a relationship exists between the lupus diathesis and lymphoreticular neoplasia. The study of the incidence of neoplasia in families of patients with SLE may prove helpful in establishing this relationship.

Topics: Aortic Diseases; Autopsy; Blindness; Bone Marrow; Digoxin; Drug Therapy, Combination; Heart Diseases; Heparin; Humans; Immunologic Deficiency Syndromes; Kidney; Lupus Erythematosus, Systemic; Lymph Nodes; Lymphoma; Male; Middle Aged; Procainamide; Quinidine; Retinal Artery; Spleen; Thromboembolism; Warfarin