digoxin and Hyperthyroidism

digoxin has been researched along with Hyperthyroidism* in 45 studies

Reviews

5 review(s) available for digoxin and Hyperthyroidism

ArticleYear
[Pathophysiology of various forms of hyperthyroidism].
    Klinische Wochenschrift, 1990, Jun-19, Volume: 68, Issue:12

    Topics: Bone and Bones; Cardiovascular System; Digoxin; Hemodynamics; Humans; Hyperthyroidism; Thyroid Hormones

1990
Congestive heart failure in infancy: recognition and management.
    American heart journal, 1982, Volume: 103, Issue:6

    Topics: Acute Kidney Injury; Airway Obstruction; Anemia, Hemolytic; Arteriovenous Fistula; Asphyxia Neonatorum; Cardiac Output; Digoxin; Ductus Arteriosus, Patent; Female; Heart Failure; Humans; Hyperthyroidism; Hypoglycemia; Infant; Infant, Newborn; Isoproterenol; Medical History Taking; Pregnancy; Pulmonary Edema; Pulmonary Valve; Sepsis; Streptococcal Infections; Tachycardia, Paroxysmal; Tricuspid Valve Insufficiency

1982
[Pharmacokinetics and drug interactions of digitalis glycosides].
    Medizinische Klinik, 1976, Aug-20, Volume: 71, Issue:34

    Topics: Digitalis Glycosides; Digitoxin; Digoxin; Drug Interactions; Heart Failure; Humans; Hyperthyroidism; Hypothyroidism; Intestinal Absorption; Kidney Failure, Chronic; Molecular Conformation; Obesity

1976
Drug therapy for cardiovascular disease in the aged.
    Journal of the American Geriatrics Society, 1975, Volume: 23, Issue:3

    Cardiovascular diseases and their treatment in the aged are discussed under the headings of ischemic heart disease, hypertension, cardiac failure (with special reference to the use of diuretics and digoxin), infective carditis and thyroid disorders. Advanced age modifies the approach to treatment; the choice of drugs and the dosage must be adjusted accordingly. Possible drug interactions should also be considered. A rehabilitation program is of great benefit for many elderly cardiac patients. It should be planned individually and involve psychologic and environmental factors as well as medical therapy. After successful treatment of the acute episode, even the aged patient can undertake rewarding activities in his remaining lifetime.

    Topics: Adrenergic beta-Antagonists; Aged; Anti-Bacterial Agents; Arrhythmias, Cardiac; Benzothiadiazines; Cardiac Rehabilitation; Cardiac Surgical Procedures; Cardiovascular Diseases; Coronary Disease; Delayed-Action Preparations; Digoxin; Diuretics; Endocarditis; Female; Heart Failure; Humans; Hypertension; Hypertension, Malignant; Hyperthyroidism; Hypothyroidism; Isosorbide Dinitrate; Male; Methyldopa; Middle Aged; Nitroglycerin; Sodium Chloride Symporter Inhibitors

1975
Advances in medicine.
    The Practitioner, 1972, Volume: 209, Issue:252

    Topics: Anemia, Macrocytic; Anti-Arrhythmia Agents; Anticoagulants; Azathioprine; Chemical and Drug Induced Liver Injury; Cholelithiasis; Clofibrate; Colitis, Ulcerative; Dextrans; Digoxin; Drug Therapy; Fibrinolytic Agents; Halothane; Heparin; Hepatitis B Antigens; Humans; Hyperthyroidism; Iodine Isotopes; Leukemia; Myocardial Infarction; Platelet Adhesiveness; Pulmonary Embolism; Thrombosis; Venoms

1972

Trials

2 trial(s) available for digoxin and Hyperthyroidism

ArticleYear
[Pharmacokinetics of digoxin in hyperthyroidism. Effect of methimazole].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2010, Volume: 63, Issue:1

    Cardiovascular abnormalities may be the only manifestations of overt hyperthyroidism. In patients with heart failure and atrial fibrillation digoxin can be beneficial in controlling the symptoms and signs, but hyperthyroid patients show an impaired response or even resistance to digoxin treatment. The aim of the study is to establish: 1. Are there any differences in the pharmacokinetics of a single oral dose of digoxin between hypertyroid and euthyroid patients? 2. Does simultaneous administration of digoxin and methimazole affect the pharmacokinetics of a single oral dose of dogoxin? 3. Does methimazole-induced euthyroidism change the pharmacokinetics of a single oral dose of digoxin?. The subject of the study were 28 patients with hyperthyroidism and 15 healthy persons. We evaluated the pharmacokinetics of a single oral dose of digoxin. Moreover we evaluated pharmacokinetics of a single dose of digoxin after simultaneous administration of digoxin and methimazole in 12 patients and 12 methimazole treated patients werere-assessed once they had become euthyroid.. Hyperthyroid patients showed significantly lower serum digoxin concentrations, shorter T1/2 beta and a significantly smaller area under the concentration curve (AUC) that the control group. Administration of methimazole did not affect digoxin pharmacokinetics.. In hyperthyroid patients: 1. the pharmacokinetics of a single oral dose of digoxin does differ from that observed in healthy subjects. 2.methimazole do not alter digoxin pharmacokinetics.

    Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Antithyroid Agents; Area Under Curve; Digoxin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hyperthyroidism; Male; Methimazole

2010
Serum digoxin in patients with thyroid disease.
    British medical journal, 1975, Sep-06, Volume: 3, Issue:5983

    Serum digoxin concentrations were measured by radioimmunoassay in 17 hyperthyroid and 16 hypothyroid patients after a seven-day course of oral digoxin. The significantly higher levels of serum digoxin in patients with hypothyroidism and lower levels in those with hyperthyroidism were closely related to the measured changes of glomerular filtration rate and digoxin serum half time in these two groups. Differences in serum digoxin concentration contribute to the altered sensitivity to digoxin shown by patients with thyroid disease.

    Topics: Administration, Oral; Adult; Clinical Trials as Topic; Creatinine; Digoxin; Female; Glomerular Filtration Rate; Half-Life; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Thyroid Diseases; Time Factors

1975

Other Studies

38 other study(ies) available for digoxin and Hyperthyroidism

ArticleYear
The impact of thyroid disease on the regulation, expression, and function of ABCB1 (MDR1/P glycoprotein) and consequences for the disposition of digoxin.
    Clinical pharmacology and therapeutics, 2010, Volume: 88, Issue:5

    The impact of thyroid dysfunction on the regulation, expression, and function of ABCB1 remains unclear. We therefore investigated ABCB1 mRNA expression and function in patients with thyroid dysfunction and studied the disposition of the ABCB1 substrate digoxin before and after treatment for thyroid disease. In patients with hypothyroidism, normalization of thyroid function was associated with a 1.8-fold increase in mRNA expression and a 26% increase in rhodamine efflux from CD56(+) cells. In hypothyroidism, digoxin clearance was significantly decreased, whereas bioavailability, volume of distribution, half-life time, and protein binding were unaltered. In hyperthyroidism, ABCB1 mRNA expression, rhodamine efflux, and disposition of digoxin were not significantly affected other than in relation to renal clearance. Experiments using the LS174T cell line indicated that the gene is a direct target of thyroid hormone receptors. In conclusion, thyroid abnormalities can exert significant effects on the expression of P-glycoprotein, thereby altering the disposition and action of drugs that are substrates of P-glycoprotein.

    Topics: Administration, Oral; Adult; Aged; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cardiotonic Agents; Digoxin; Enhancer Elements, Genetic; Female; Gene Expression Regulation; Humans; Hyperthyroidism; Hypothyroidism; Infusions, Intravenous; Male; Middle Aged; Rhodamines; RNA, Messenger; Thyroid Hormones; Transfection; Young Adult

2010
[Charles Bonnet syndrome in an elderly patient with bilateral vision loss, hyperthyroidism and relative digitalis overdose].
    Der Nervenarzt, 2002, Volume: 73, Issue:5

    Charles Bonnet syndrome (CBS) is characterized by the presence of visual hallucinations in elderly, mentally healthy people. We report a visually impaired 90-year-old woman suddenly complaining of visual hallucinations, suffering from hyperthyroidism and a relative digitalis overdose. The diagnosis of CBS could be made after the exclusion of an intoxication and other neurological and psychiatric syndromes. In this case, visual hallucinations ceased without specific psychopharmacological therapy. A brief review of this organic hallucinosis, differential diagnosis, especially hyperthyroidism-induced psychosis, and digitoxin-induced psychosis is given and current therapeutic strategies are suggested.

    Topics: Aged; Aged, 80 and over; Delusions; Diagnosis, Differential; Digoxin; Drug Overdose; Female; Hallucinations; Herpes Zoster Ophthalmicus; Humans; Hyperthyroidism; Patient Care Team; Vision, Low

2002
[Digoxin as a cause of chromatopsia and depression in a patient with heart failure and hyperthyroidism].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2000, Volume: 9, Issue:50

    67 year old patient with chronic heart failure and persistent atrial fibrillation had overdosed glycosides for several months. The symptoms of gastrointestinal system and nervous system appeared after long term therapy with toxic doses of glycosides. Originally depression was diagnosed based on the central nervous system disturbances. Even though overdose of glycosides was diagnosed the blood serum glycoside level was within the therapeutic limits. Based on the precise analysis of the data, it was concluded that the reason for normal blood serum glycoside level in this case was coexisting hyperthyreosis.

    Topics: Aged; Atrial Fibrillation; Color Vision Defects; Depression; Digoxin; Drug Overdose; Heart Failure; Humans; Hyperthyroidism; Male

2000
Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin in hyper- and hypo-thyroid rats.
    Clinical science (London, England : 1979), 1991, Volume: 81, Issue:4

    1. Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin and other parameters related to salt and water metabolism were studied in hyper- and hypo-thyroid rats after different tests. 2. Urinary excretion of arginine-vasopressin was increased in hyperthyroid and reduced in hypothyroid rats with respect to controls, in response to water deprivation or a hypertonic saline load. 3. Control and hypothyroid rats showed the highest urinary excretion of digoxin-like immunoreactive factor after a hypertonic saline load. However, hyperthyroid rats had the highest urinary levels of digoxin-like immunoreactive factor under normal conditions. 4. From these results it is suggested that: (a) hyper- and hypo-thyroid rats exhibit hyper- and hypo-responsiveness of arginine-vasopressin secretion to osmotic stimuli, respectively; (b) an unidentified digoxin-like immunoreactive factor measured in unextracted rat urine may be related to diuresis and natriuresis in control and hypothyroid rats; however, dissociation between this factor and natriuresis is observed in hyperthyroid rats.

    Topics: Animals; Arginine Vasopressin; Blood Proteins; Cardenolides; Digoxin; Hyperthyroidism; Hypothyroidism; Kidney; Male; Methimazole; Rats; Rats, Inbred Strains; Saline Solution, Hypertonic; Saponins; Sodium-Potassium-Exchanging ATPase; Thyroxine; Water Deprivation

1991
Hyperthyroid-induced atrial flutter-fibrillation with profound sinoatrial nodal pauses due to small doses of digoxin, verapamil, and propranolol.
    Clinical cardiology, 1989, Volume: 12, Issue:1

    Atrial fibrillation due to hyperthyroidism is characterized by a rapid ventricular response which is typically resistant to digoxin therapy. We report a patient with atrial flutter-fibrillation who developed cyclic sinus node dysfunction with profound ventricular pauses in response to small doses of digoxin, verapamil, and propranolol, which resolved with discontinuation of the medications. Caution is necessary to avoid paradoxical ventricular slowing when treating hyperthyroid-induced atrial fibrillation.

    Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Digoxin; Female; Humans; Hyperthyroidism; Middle Aged; Propranolol; Verapamil

1989
[Endogenous digitalis-like substance and Na-K-ATPase inhibitor in cardiovascular and renal disease].
    Nihon Naibunpi Gakkai zasshi, 1988, Jan-20, Volume: 64, Issue:1

    New method for measuring plasma and urinary Na-K-ATPase inhibitor (ATPI) was developed. Plasma and urine were extracted with reversed phase cartridge column and sample was reconstituted by assay buffer. Na-K-ATPase inhibitory activity of sample was monitored by continuously recording the absorbance of NADH at 340 nm, which coupled to the dephosphorylation of ATP. Ouabain was used for standards of Na-K-ATPase inhibition and this standard showed good linearity ranged 5-100 nmol/ml. Using this new method, P-ATPI and U-ATPI were quantitatively evaluated and paradoxical Na-K-ATPase stimulating phenomenon which observed in conventional method (Hamlyn et al) was diminished. Adopting of this new method for measuring plasma(P-) and urinary(U-)ATPI, and radioimmunoassay for P- and U-digitalis-like substance(DLS)--using crossreactivity to anti digoxin antibody--, these substances were estimated in patients with essential hypertension (EHT), chronic heart failure(CHF), primary and idiopathic hyperaldosteronism(HA), hyperthyroidism(BA) and chronic renal failure(CRF). In EHT, U-DLS, P-DLS, U-ATPI, P-ATPI were significantly higher than those of control(C). In CHF and BA, U-DLS and -ATPI were also significantly higher than those of C. In HA, U-ATPI, DLS distributed in wide range, and a few patients showed high levels of U-DLS and -ATPI. In CRF, P-DLS and -ATPI levels were significantly higher than those of C in prehemodialytic state but P-ATPI was significantly decreased after hemodialysis. From these results it is suggested that 1) DLS and ATPI might contribute to the etiology of hypertension. 2) Volume expansion stimulates the secretion of DLS and ATPI. 3) Stimulatory effect of volume expansion and inhibitory effect of mineralocorticoid may be responsible for wide distribution of these factors in HA. 4) DLS and ATPI are not the same substances.

    Topics: Adult; Blood Proteins; Cardenolides; Cardiovascular Diseases; Digoxin; Female; Humans; Hyperaldosteronism; Hypertension; Hyperthyroidism; Kidney Diseases; Male; Middle Aged; Saponins; Sodium-Potassium-Exchanging ATPase

1988
Hyperthyroid heart disease.
    Clinics in endocrinology and metabolism, 1985, Volume: 14, Issue:2

    The importance of cardiovascular system involvement in hyperthyroidism has been recognized for many years. In the middle-aged and elderly patient, often with mild but prolonged elevation of plasma thyroid hormones, symptoms and signs of heart failure and complicating atrial fibrillation may dominate the clinical picture and mask the more classical endocrine manifestations of the disease. Pitfalls in diagnosis and the importance of early recognition and treatment are discussed. Despite experimental evidence for a short-term inotropic action of thyroid hormone excess, clinical data support the existence of a reversible cardiomyopathy in hyperthyroidism with impaired contractile reserve. Enhanced myocardial performance at rest primarily reflects the peripheral actions of thyroid hormone excess. Most, if not all, of the cardiac abnormalities return to normal once a euthyroid state has been achieved, although atrial fibrillation may persist in a minority. Optimum treatment requires rapid and definitive antithyroid therapy, usually using a large dose of radio-iodine, and rapid control of heart failure. Systemic anticoagulation is indicated in the presence of atrial fibrillation and should be continued until sinus rhythm has been present for at least three months, either spontaneously or after cardioversion.

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiomyopathies; Digoxin; Drug Therapy, Combination; Heart Diseases; Heart Rate; Hemodynamics; Humans; Hyperthyroidism; Myocardial Contraction; Myocardial Infarction; Sympathetic Nervous System; Thyroid Function Tests; Thyroid Hormones

1985
[Serum level of digoxin and digitoxin and glomerular filtration rate in hyper- and hypothyroidism].
    Deutsche medizinische Wochenschrift (1946), 1983, Mar-11, Volume: 108, Issue:10

    In a comparative prospective study the serum levels of digoxin and digitoxin and the glomerular filtration of the kidneys were determined radioimmunologically in thyroid function disorders using the endogenous creatinine clearance and the 51Cr-EDTA clearance. Compared to a euthyroid control group 17 patients with hyperthyroidism showed a decreased and 5 patients with hypothyroidism showed a largely toxic digoxin level, both groups being on a maintenance therapy of 0.25 mg digoxin b. i. d. During an oral maintenance therapy of daily 0.1 mg digitoxin unchanged therapeutic serum levels were found in 35 hyperthyroid and 18 hypothyroid patients when compared to a euthyroid control group. Assessment of clearances showed that glomerular filtration rates were clearly increased in the hyperthyroid and lowered in the hypothyroid patients. Renewed assessment of the clearance in four hyperthyroid patients and three with hypothyroidism after thyroid recompensation showed a marked decrease of clearance values in hyperthyroidism and an increase in hypothyroidism. Increased clearance values in hyperthyroidism were associated with lowered digoxin serum levels. In contrast, lowered clearance values in hypothyroidism were accompanied by increased serum digoxin levels. There was no such association detectable for digitoxin.

    Topics: Adult; Aged; Creatinine; Digitoxin; Digoxin; Glomerular Filtration Rate; Humans; Hyperthyroidism; Hypothyroidism; Middle Aged

1983
Digoxin kinetics in the elderly.
    Age and ageing, 1983, Volume: 12, Issue:1

    Digoxin elimination phase kinetics have been studied in 24 hospital in-patients (mean age 79 years), six of whom showed no evidence of digoxin toxicity. The others, with suspected toxicity, have been grouped according to the nature of the drug effects observed. Renal function, digoxin elimination half-life, apparent volume of digoxin distribution, and notional body content of digoxin have been compared between the groups. Apart from two hyperthyroid patients, the volumes of distribution averaged 6.1 1/kg. Toxic patients tended to have lower creatinine clearances, longer digoxin half-lives, and higher body contents of digoxin than the nontoxic, but the highest body contents were found in those with systemic toxicity. Thyrotoxicosis increases the apparent volume of digoxin distribution in the elderly.

    Topics: Aged; Body Burden; Creatinine; Digoxin; Female; Half-Life; Humans; Hyperthyroidism; Kinetics; Male

1983
[Studies on pharmacokinetics of digoxin in hyperthyroid and hypothyroid dogs].
    Japanese circulation journal, 1982, Volume: 46 Suppl 3

    Topics: Animals; Digoxin; Dogs; Female; Hyperthyroidism; Hypothyroidism; Kidney; Kinetics; Radioimmunoassay

1982
[Therapy of cardiac insufficiency with digitalis glycosides].
    Fortschritte der Medizin, 1981, May-14, Volume: 99, Issue:18

    Topics: Adrenergic beta-Antagonists; Digitalis Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Heart Failure; Humans; Hyperthyroidism; Kidney Failure, Chronic; Liver Diseases; Quinidine

1981
The relationship between sodium transport and Na+, K+ ATPase in human erythrocytes.
    Biochemical medicine, 1981, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Biological Transport, Active; Digoxin; Erythrocytes; Female; Humans; Hyperthyroidism; Kidney Failure, Chronic; Male; Middle Aged; Ouabain; Sodium; Sodium-Potassium-Exchanging ATPase

1981
Relations between sodium transport and sodium concentration in human erythrocytes in health and disease.
    Clinical science (London, England : 1979), 1981, Volume: 60, Issue:5

    1. We have examined the inter-relationships between erythrocyte sodium content and sodium transport in a group of healthy subjects and in groups of patients with disorders known to change the sodium content of erythrocytes. 2. In the healthy subjects the sodium content of erythrocytes was inversely related to both the permeability of the erythrocyte membrane to sodium (as measured by the unidirectional, ouabain-sensitive, sodium efflux) and the total activity of the sodium pumps (as measured by the rate constant of ouabain-sensitive sodium efflux). There was a correlation between the total activity of the sodium pumps and the membrane permeability to sodium. 3. Changes in the erythrocyte sodium content were due to a decrease in the activity of the sodium pumps (as in hypokalaemia and digoxin treatment), or a decrease in the permeability of the erythrocyte membrane to sodium (as in chronic renal failure) or a reduction of both the membrane permeability and the number of sodium pumps (as in hyperthyroidism or elderly patients). 4. One interpretation of the results in the healthy subjects is that there are two components of sodium influx; one associated with the sodium pumps in what we have called 'membrane-units' and the other determined by the ground permeability of the membrane. 5. On the basis of this model we suggest that in the geriatric and hyperthyroid patients there is a reduction in the number of 'membrane-units', that in hypokalaemia and during digoxin treatment there is inhibition of the sodium-pump component of the 'membrane-units' and that in chronic renal failure there is a decrease in the permeability of the membrane to sodium.

    Topics: Adult; Age Factors; Aged; Biological Transport, Active; Digoxin; Erythrocytes; Female; Humans; Hyperthyroidism; Hypokalemia; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Ouabain; Sodium

1981
[Digoxin-like immunoreactivity in serum of hyperthyroid rats with hypertrophy of the heart is not caused by aldosterone (author's transl)].
    Sbornik lekarsky, 1980, Volume: 82, Issue:10

    Topics: Animals; Cardiomegaly; Digoxin; Hyperthyroidism; Immunoenzyme Techniques; Male; Rats

1980
Failure of the aldosterone antagonist spironolactone to inhibit myocardial hypertrophy produced by experimental hyperthyroidism and accompanied by "apparent" digoxin immunoreactivity in the blood.
    Physiologia Bohemoslovaca, 1980, Volume: 29, Issue:6

    Topics: Animals; Antigen-Antibody Reactions; Cardiomegaly; Digoxin; Heart; Hyperthyroidism; Male; Organ Size; Rats; Spironolactone; Thyroxine

1980
Distribution of digoxin in hyperthryoid patients.
    International journal of clinical pharmacology, therapy, and toxicology, 1980, Volume: 18, Issue:5

    Topics: Digoxin; Humans; Hyperthyroidism; Models, Biological

1980
[Serum levels and kinetics of digoxin in patients with hyperthyroidism (author's transl)].
    Giornale italiano di cardiologia, 1980, Volume: 10, Issue:7

    The mechanism of reduced sensitivity to digitalis in patients with hyperthyroidism has been attributed to a change of intrinsic myocardial function and/or to altered pharmacokinetics of cardiac glycosides. Digoxin kinetics have been studied in hyperthyroid and 8 euthyroid patients after a single oral and i.v. dose at steady-state. Plasma and urinary digoxin concentrations were determined by radioimmunoassay. A significantly mean lower serum digoxin concentration was found in hyperthyroid patients, both after a single oral drug administration and at the steady-stage. A decreased digoxin absorption could not account for this finding, since both the percentage of gastrointestinal uptake of the drug and maximal serum concentration did not differ in hyperthyroid patients as compared to controls. Hyperthyroid subjects showed, on the contrary, an expended distribution volume and a significantly higher excretion, as documented by a lower drug half-life, by the increase of the elimination constant and urinary digoxin output.

    Topics: Adult; Aged; Digoxin; Female; Heart Failure; Humans; Hyperthyroidism; Kinetics; Male; Middle Aged

1980
[Absorption and secretion of digoxin in soft gelatin capsules in hyperthyroidism].
    Bollettino della Societa italiana di cardiologia, 1978, Volume: 23, Issue:6

    Topics: Adult; Capsules; Digoxin; Female; Humans; Hyperthyroidism; Male

1978
The pharmacokinetics of digoxin in patients with manifest hyperthyroidism and after normalization of thyroid function.
    International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:7

    The pharmakokinetic data (elimination half-life, apparent distribution volume, total and renal clearance and cumulative urine excretion) were determined after intravenous administration of 1 mg digoxin in 9 female patients with an average age of 52 +/- 15 years with manifest hyperthyroidism. The study protocol was repeated after normalization of thyroid function by means of conventional thyrostatic therapy. Digoxin was determined by radioimmunoassay.

    Topics: Aged; Digoxin; Female; Half-Life; Humans; Hyperthyroidism; Kinetics; Middle Aged; Time Factors

1978
Plasma and urinary digoxin in thyroid dysfunction.
    European journal of clinical pharmacology, 1977, Dec-28, Volume: 12, Issue:6

    The response to a single oral dose of 0.5 mg digoxin has been studied in eight patients, of whom four were hyperthyroid and four were hypothyroid, both before and after treatment for their thyroid dysfunction. The post-dose plasma digoxin levels were significantly lower in the hyperthyroid patients when they were thyrotoxic than when they became euthyroid. In only one hypothyroid patient was the post-dose plasma digoxin level significantly higher before treatment than it was after and in the others the digoxin values reached were either the same as, or lower than, before treatment. There was a significant correlation between the creatinine clearance and the urinary concentrations of digoxin and these both altered with change in thyroid status. Total urinary digoxin excretion did not change. Pharmacokinetic analysis suggested that digoxin was distributed in a way compatible with a two-compartment model and that the volume of the central compartment was high in thyrotoxic patients and low in hypothyroid patients. In both cases it reverted to a median value after treatment. It is recommended that plasma digoxin levels should be monitored in all patients with thyroid dysfunction who require therapeutic digoxin.

    Topics: Aged; Digoxin; Female; Humans; Hyperthyroidism; Hypothyroidism; Iodine Radioisotopes; Middle Aged; Models, Biological

1977
[The importance of body weight in treatment with digoxin and digoxin derivatives (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1977, Jan-28, Volume: 102, Issue:4

    A total of 1109 determinations of digoxin concentration in serum were performed in 317 patients with cardiac failure during oral maintenance therapy with digoxin, beta-acetyldigoxin and beta-methyldigoxin. It was shown that the optimal therapeutic serum concentration (1.21 to 1.70 ng/ml) can be obtained reliably if the dosage of digoxin and its derivatives is based on the body weight. The daily doses recommended for oral maintenance therapy are 4mug/kg for beta-methyldigoxin, 5 mug/kg for beta-acetyldigoxin, and 8 mug/kg for digoxin. For initiating cardiac therapy the double maintenance dose can be prescribed once. Digoxin derivatives should be preferred to digoxin when choosing the drug.

    Topics: Aged; Body Weight; Digoxin; Female; Heart Failure; Humans; Hyperthyroidism; Male; Middle Aged; Sex Factors

1977
Digoxin kinetics in patients with thyroid dysfunction.
    Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:1

    Topics: Administration, Oral; Adult; Aged; Creatinine; Digoxin; Female; Glomerular Filtration Rate; Humans; Hyperthyroidism; Hypothyroidism; Injections, Intravenous; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Thyroid Diseases

1977
[Analysis of the structure of cardiac rhythm during treatment of auricular fibrillation with digitalis].
    Kardiologiia, 1977, Volume: 17, Issue:4

    The structure of cardiac rhythm was studied with the help of specialized computers during digitalization in 60 patients with atrial fibrillation of different etiology. The reduction of the heart contractions rate under digitalization is accompanied by certain changes in the structure of cardiac rhythm: the arrhythmic pattern of the ventricular contractions increases with a predominant growth of the number of long R--R intervals, the transitions from short intervals to longer ones become sharper, and portions of a relatively stable ventricular rhythm appear. Three main types of dynamics of the rhythm structure were distinguished on the basis of the changes in the interval R--R histogram. The described changes in the structure of cardiac rhythm are not specific, but when Digitalis drugs are used alone they can be used as additional criteria for digitalization.

    Topics: Adult; Aged; Atrial Fibrillation; Atrioventricular Node; Coronary Disease; Digoxin; Electrocardiography; Heart Conduction System; Humans; Hyperthyroidism; Middle Aged; Rheumatic Heart Disease

1977
Digoxin in hyperthyroidism.
    Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:5 Pt 1

    A patient with chronic atrial fibrillation developed hyperthyroidism. Increasing doses of digoxin were required to maintain satisfactor ventricular rate control. The systemic availability of oral digoxin was decreased in this patient. The metabolism of digoxin was studied in the hyperthyroid rats. The plasma digoxin concentrations were significantly decreased in the hyperthyroid rats. A threefold increase in digoxin excretion in the bile of the hyperthyroid rats was associated with these changes in plasma digoxin concentrations. Conversely, hypothyroid rats excreted less digoxin in the bile when compared with control and hyperthyroid rats. Thus, changes in digoxin absorption and its biliary excretion result, in part, in a decreased therapeutic effect of digoxin based on dose in hyperthyroidism.

    Topics: Animals; Atrial Fibrillation; Bile; Digoxin; Female; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Middle Aged; Rats

1977
Pharmacokinetics in drug therapy. I: Propranolol hydrochloride as adjunct therapy in the treatment of thyrotoxicosis.
    American journal of hospital pharmacy, 1976, Volume: 33, Issue:2

    A case study in which propranolol hydrochloride was used as adjunct therapy in the treatment of atrial fibrillation with rapid ventricular response, thyrotoxicosis and high output heart failure is presented to illustrate the pharmacokinetics of this drug. The relationship of propranolol dosage to blood levels, the effect of blood levels on pharmacological response, the metabolism and elimination of propranolol, and determination of rational dosage of the drug, are discussed.

    Topics: Antithyroid Agents; Blood Urea Nitrogen; Digoxin; Female; Humans; Hyperthyroidism; Kinetics; Middle Aged; Propranolol

1976
[Studies on the pharmacokinetics of digoxin in patients with hyperthyroidism].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 2

    Topics: Adult; Digoxin; Humans; Hyperthyroidism; Kinetics; Metabolic Clearance Rate; Middle Aged

1976
Letter: Serum digoxin in patients with thyroid disease.
    British medical journal, 1976, Jul-17, Volume: 2, Issue:6028

    Topics: Digoxin; Humans; Hyperthyroidism

1976
Letter: Serum digoxin in patients with thyroid disease.
    British medical journal, 1975, Oct-11, Volume: 4, Issue:5988

    Topics: Celiac Disease; Digoxin; Humans; Hyperthyroidism; Malabsorption Syndromes

1975
Clinical application of digitalis glycosides.
    American family physician, 1974, Volume: 10, Issue:3

    Topics: Administration, Oral; Aged; Arrhythmias, Cardiac; Digitalis Glycosides; Digitoxin; Digoxin; Heart Block; Heart Diseases; Heart Failure; Humans; Hyperthyroidism; Injections, Intravenous; Kidney Failure, Chronic; Middle Aged; Obesity; Ventricular Fibrillation

1974
Death from thyrotoxicosis.
    Lancet (London, England), 1973, Oct-20, Volume: 2, Issue:7834

    Topics: Adult; Age Factors; Aged; Death, Sudden; Digoxin; Diuretics; Female; Graves Disease; Heart Failure; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Middle Aged; Postoperative Complications; Prognosis; Pulmonary Embolism; Sex Factors; Tachycardia; Thyroid Crisis

1973
Intractable paroxysmal tachycardia in thyrotoxicosis simulating myocardial infarction.
    Acta medica Scandinavica, 1972, Volume: 192, Issue:5

    Topics: Angina Pectoris; Atrial Fibrillation; Bradycardia; Cardiac Catheterization; Diagnosis, Differential; Diagnostic Errors; Digoxin; Electrocardiography; Humans; Hyperthyroidism; Lidocaine; Male; Middle Aged; Myocardial Infarction; Procainamide; Tachycardia; Tachycardia, Paroxysmal; Thyroxine

1972
Atrial fibrillation. I.
    British medical journal, 1971, Jul-24, Volume: 3, Issue:5768

    Topics: Aged; Atrial Fibrillation; Digoxin; Epinephrine; Humans; Hyperthyroidism; Isoproterenol; Male; Middle Aged; Propranolol; Quinidine; Ventricular Fibrillation

1971
Hypercalcemia, heart-block, and hyperthyroidism.
    JAMA, 1970, Aug-24, Volume: 213, Issue:8

    Topics: Arrhythmia, Sinus; Calcium; Digoxin; Female; Heart Block; Humans; Hypercalcemia; Hyperthyroidism; Middle Aged; Procainamide

1970
Digoxin metabolism in hypo- and hyperthyroidism. Studies with tritiated digoxin in thyroid disease.
    Annals of internal medicine, 1966, Volume: 64, Issue:3

    Topics: Adult; Aged; Basal Metabolism; Blood Urea Nitrogen; Digoxin; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Thyroid Function Tests; Tritium

1966
Survival time of circulating long-acting thyroid stimulator in neonatal thyrotoxicosis: implications for diagnosis and therapy of the disorder.
    Pediatrics, 1965, Volume: 36, Issue:6

    Topics: Adolescent; Digoxin; Female; Humans; Hyperthyroidism; Infant; Infant, Newborn; Infant, Newborn, Diseases; Long-Acting Thyroid Stimulator; Phenobarbital; Prednisolone; Tetracycline; Thyroiditis

1965
NEONATAL GRAVES' DISEASE.
    American journal of diseases of children (1960), 1964, Volume: 107

    Topics: Arrhythmias, Cardiac; Clinical Laboratory Techniques; Digoxin; Female; Goiter; Graves Disease; Hepatomegaly; Humans; Hyperthyroidism; Hypoprothrombinemias; Infant; Infant, Newborn; Infant, Newborn, Diseases; Iodides; Liver Diseases; Maternal-Fetal Exchange; Prednisolone; Pregnancy; Pregnancy Complications; Reserpine; Splenomegaly; Thrombocytopenia; Toxicology; Vitamin K

1964
NEONATAL HYPERTHYROIDISM.
    The Journal of pediatrics, 1964, Volume: 64

    Topics: Adrenocorticotropic Hormone; Digoxin; Female; Genetics, Medical; Goiter; Graves Disease; Humans; Hyperthyroidism; Infant; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Propylthiouracil; Thymus Gland; Thyroid Gland; Thyrotoxicosis

1964
THE HEART AND DIGITALIS.
    British medical journal, 1963, Sep-07, Volume: 2, Issue:5357

    Topics: Digitalis; Digitalis Glycosides; Digoxin; Heart; Heart Failure; Humans; Hyperthyroidism

1963