digoxin and Hemangioma

Infantile hepatic haemangiomas are benign tumours which tend to regress in late infancy. We describe five infants with hepatic haemangioma, three of whom developed congestive cardiac failure. Technetium-99m labelled red blood cell scan was useful in the diagnosis and follow-up of the lesion. The three symptomatic infants were treated with prednisone (2 mg/kg per day) for 2 months in addition to digoxin and diuretics. Significant clinical improvement occurred within 3 weeks in each case. We conclude that the red blood cells scan is a good non-invasive diagnostic test and recommend corticosteroids as initial management for symptomatic infantile hepatic haemangiomas.

Topics: Diagnostic Imaging; Digoxin; Diuretics; Female; Heart Failure; Hemangioma; Humans; Infant; Infant, Newborn; Liver Neoplasms; Male; Prednisone

Topics: Digoxin; Female; Heart Failure; Hemangioma; Hemorrhage; Humans; Infant; Skin Neoplasms; Subclavian Artery; Thoracic Neoplasms; Wound Infection

A case of multiple neonatal haemangiomatosis is reported. The disease entity is rare and probably always combined with haemangiomas of internal organs. When visceral involvement provokes clinical symptoms (cardiac, cerebral, gastrointestinal), the spontaneous course often proves fatal. The prognosis seems to improve substantially if treatment with systemic corticosteroids is instituted. The patient reported, who had concomitant cardiac and gastrointestinal symptoms, recovered completely following corticosteroid treatment. It is concluded that steroid treatment is indicated without hazards in complicated cases of multiple neonatal haemangiomatosis.

Topics: Angiomatosis; Digoxin; Female; Heart Defects, Congenital; Hemangioma; Humans; Infant; Prednisone; Skin; Skin Neoplasms

Fifty-eight cases of concurrent cutaneous and hepatic hemangiomatosis in infants have been reported in the world literature. A fifty-ninth case is herewith reported and the literature is reviewed. Untreated cases have a mortality rate of 81%, whereas the mortality of treated cases is 29%. The main cause of death appears to be the consequence of arteriovenous shunting in the liver. Early and aggressive treatment by prednisone, radiotherapy to the liver, partial resection of liver, and ligation of the hepatic artery, each alone or in combinations, have been effective.

Topics: Digoxin; Female; Heart Failure; Hemangioma; Humans; Infant; Infant, Newborn; Liver Neoplasms; Neoplasms, Multiple Primary; Prednisone; Prognosis; Skin Neoplasms

Topics: Animals; Ascites; Digoxin; Diuretics; Dog Diseases; Dogs; Hemangioma; Liver; Male; Pleural Neoplasms; Radiography

Topics: Adrenal Cortex Hormones; Digoxin; Female; Heart Failure; Hemangioma; Humans; Infant, Newborn; Liver Neoplasms; Prednisone

Topics: Arteriovenous Fistula; Black People; Digoxin; Drug Therapy; Heart Failure; Hemangioendothelioma; Hemangioma; Hepatomegaly; Humans; Liver Diseases; Neoplasm Regression, Spontaneous