digoxin and Gynecomastia

Digoxin was studied to see whether it impairs adrenal function and feminizes male subjects by changing plasma sexual hormones; both have been reported on previously. In eight healthy male subjects neither estrone (38.7 +/- 7.7 vs 35.4 +/- 3.2 pg/ml) nor estradiol (35.8 +/- 6.4 vs 32.2 +/- 3.9 pg/ml) nor testosterone (6.32 +/- 0.74 vs 6.45 +/- 0.73 ng/ml) were found to be altered by digoxin administration (plasma levels 1.55 +/0- 0.27 ng/ml) lasting 35 days. The same was true of free testosterone (147 +/- 24 vs 142 +/- 19 pg/ml) and free estradiol (657 +/- 77 vs 615 +/- 78 fg/ml). Even maximal stimulation of the adrenal and gonadal glands by adrenocorticotropic hormone (ACTH) and human chorionic gonadotropin (hCG) did not exhibit any digoxin-induced alterations in the synthesizing capacity of steroid hormones, as shown by plasma cortisol (increase from 128 +/- 18 to 389 +/- 18 ng/ml) and testosterone (from 5.96 +/- 0.90 to 10.33 +/- 1.19 ng/ml). Furthermore, seven subjects on digoxin were observed over a period of 150-210 days; they did not show any increase of estrogens. This was also found in three subjects when estrogen levels were elevated initially due to extreme obesity. Also, 35 patients who took beta-methyldigoxin (n = 8), beta-acetyldigoxin (n = 20) and digitoxin (n = 7) from 1 to 9 (mean: 1.9) years demonstrated normal plasma concentrations of gonadal and adrenal steroids, irrespective of duration of application or the digitalis compound.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Adrenal Cortex Hormones; Adult; Digitalis; Digoxin; Gonadal Steroid Hormones; Gynecomastia; Heart Failure; Hemodynamics; Humans; Male; Plants, Medicinal; Plants, Toxic; Sex Factors

Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Flutter; Diagnosis, Differential; Digoxin; Gynecomastia; Humans; Male

D.G. was a 59-year-old male patient who was retired and married, and had 3 children. He reported no psychopathology prior to a myocardial infarction he had in 1996. Following bypass surgery he had erectile dysfunction. Subsequently, gynecomastia developed as a side effect of spironolactone and digoxin treatment. After a long period of depression he claimed was caused by non-adaptation to the changes in his body, he realized differences about himself; he began to feel like a woman. Upon referral to our clinic, he said that he had decided to continue his life as a woman and wished to get pink colored (as opposed to blue for male) identity card issued by the Turkish Government for female Turkish citizens. He reported that his wish was to learn how to become a woman. This is the first case in the medical literature defined as sexual identity disorder secondary to a general medical condition. The case is discussed in terms of pathological grief reaction.

Topics: Bereavement; Depression; Digoxin; Erectile Dysfunction; Female; Gender Identity; Gynecomastia; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Spironolactone

The accumulation of 99mTc(V)-DMSA in bilateral breasts was recognized in a 60-year-old male with drug-induced gynecomastia. There are some reports describing 99mTc(V)-DMSA accumulation in normal female breast, fibrous dysplasia of the breast and metastatic lesions of breast carcinoma, but to my knowledge, there have been no reports describing 99mTc(V)-DMSA accumulation in gynecomastia.

Topics: Digoxin; Furosemide; Gynecomastia; Humans; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Spironolactone; Technetium Tc 99m Dimercaptosuccinic Acid

Topics: Acetyldigoxins; Adult; Digoxin; Gynecomastia; Hormones; Humans; Male

Topics: Digitalis; Digoxin; Female; Gastrointestinal Diseases; Gynecomastia; Humans; Male; Mental Disorders; Neuromuscular Diseases; Plants, Medicinal; Plants, Toxic

Topics: Aged; Angina Pectoris; Diagnosis, Differential; Digoxin; Gynecomastia; Humans; Male; Middle Aged

Topics: Aged; Bronchial Neoplasms; Digoxin; Gynecomastia; Humans; Male; Middle Aged; Spironolactone; Tamoxifen

Topics: Aged; Digoxin; Gynecomastia; Humans; Male

Topics: Adult; Age Factors; Aged; Digoxin; Estrogens; Female; Gonadotropins; Gynecomastia; Humans; Luteinizing Hormone; Male; Menopause; Middle Aged; Sex Factors; Testosterone; Time Factors

Topics: Aged; Arrhythmias, Cardiac; Digitalis; Digitalis Glycosides; Digoxin; Diuretics; Geriatrics; Gynecomastia; Heart Failure; Humans; Male; Psychoses, Substance-Induced; Psychotic Disorders; Toxicology

Topics: Bradycardia; Delirium; Digitalis; Digitalis Glycosides; Digitoxin; Digoxin; Gynecomastia; Humans; Lanatosides; Male; Neuritis; Paresthesia; Tachycardia; Thrombocytopenia; Toxicology; Trigeminal Neuralgia; Urticaria