digoxin and Glomerulonephritis

Variability in the response to drugs is due to three principal components-the disease, the responsiveness of tissues, and the concentration of the drug at its site of action (as reflected by its plasma concentration). The relative contributions of these components will differ not only for different drugs but also for different effects of the same drug. Rational drug therapy depends on knowledge of all three factors.

Topics: Acute Disease; Acylation; Chlorthalidone; Chronic Disease; Depression; Diazoxide; Digoxin; Dose-Response Relationship, Drug; Glomerulonephritis; Humans; Hypertension; Nephrotic Syndrome; Norepinephrine; Nortriptyline; Oxidation-Reduction; Phenylthiourea; Serotonin; Spironolactone; Steroids

Measurement of serum endogenous digitalis-like factor (EDF) concentration was carried out in 58 patients with renal impairment with radioimmunoassay. The results showed that serum EDF concentration in patients with renal impairment was markedly higher than that of normal cases. The serum EDF concentration was significantly elevated with decrease of renal function and was positively correlated with the levels of BUN and blood creatinine. The serum EDF concentration in patients with primary and secondary renal impairment was of no difference. It was found that the difference between patients with and without hypertension was statistically significant. The serum EDF concentrations were markedly decreased after hemodialysis but still higher than those of normal cases.

Topics: Adult; Aged; Blood Proteins; Blood Urea Nitrogen; Cardenolides; Creatinine; Digoxin; Female; Glomerulonephritis; Humans; Kidney Diseases; Male; Middle Aged; Renal Dialysis; Saponins; Sodium-Potassium-Exchanging ATPase

17 patients on maintenance hemodialysis were monitored for cardiac arrhythmias using ambulatory electrocardiographic recording. Atrioventricular dissociation was found in a patient with an elevated serum digoxin concentration, intradialytic supraventricular tachycardia had been present in a second patient during acute uremic pericarditis prior to the study. Ventricular premature beats (VPB) were absent or of low grade (occasional/uniform) in 14 patients and did not increase on dialysis. 3 patients had potentially dangerous VPB of higher grades (multiform, salvos or R on T) which occurred on or after dialysis in 2. 2 of these 3 patients were overdigitalized, and 2 had severe cardiac disease (amyloid, old myocardial infarction). Several other risk factors (age, hypertension, cardiac hypertrophy, smoking, hyperlipidemia, electrolyte changes) did not seem to be of importance for VPB. In these patients on maintenance hemodialysis, potentially dangerous VPB were rare and occurred mainly during or after dialysis in patients with preexisting heart disease and/or digitalization.

Topics: Arrhythmias, Cardiac; Chronic Disease; Digoxin; Electrocardiography; Female; Glomerulonephritis; Humans; Hyperlipidemias; Hypertension; Kidney Diseases; Male; Middle Aged; Phenacetin; Polycystic Kidney Diseases; Renal Dialysis; Risk

Topics: Adult; Aged; Anti-Glomerular Basement Membrane Disease; Digoxin; Female; Glomerulonephritis; Humans; Hypertension, Malignant; Lupus Vulgaris; Lymphoma; Male; Middle Aged; Multiple Myeloma; Nephrotic Syndrome; Plasma Exchange; Plasmapheresis; Purpura, Thrombocytopenic; Vasculitis; Waldenstrom Macroglobulinemia

Topics: Adult; Aged; Diabetes Mellitus; Digoxin; Female; Glomerulonephritis; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Tritium

Topics: Blood Pressure; Cardiac Catheterization; Cardiomegaly; Child; Child, Preschool; Digoxin; Diuresis; Female; Glomerulonephritis; Humans; Hypertension; Male; Nitrites; Pulmonary Artery

Topics: Adolescent; Adult; Blood; Collagen Diseases; Digoxin; Feces; Female; Glomerulonephritis; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Kidneys, Artificial; Male; Middle Aged; Polycystic Kidney Diseases; Pyelonephritis; Tritium; Urine

Topics: Anemia; Blood Pressure; Blood Pressure Determination; Blood Urea Nitrogen; Blood Volume; Cardiac Catheterization; Cardiac Output; Cardiovascular System; Dialysis; Digoxin; Drug Therapy; Glomerulonephritis; Guanethidine; Humans; Methyldopa; Peritoneal Dialysis; Pyelonephritis; Renal Dialysis; Urine