digoxin and Eye-Manifestations

Topics: Anorexia Nervosa; Color Vision Defects; Digitalis Glycosides; Digitoxin; Digoxin; Eye Manifestations; Fatigue; Humans; Medication Errors; Mental Disorders; Muscular Diseases; Nausea; Neurologic Manifestations; Poisoning; Vision Disorders

Serum digitalis concentration was measured radioimmunologically on 1006 patients in the period from 1974-1976. The serum levels were correlated with the clinical signs of digitalis toxicity and the indications for determination of the serum digoxin concentration were established. Clinical signs of toxicity appear at a serum level of digoxin above 2.5 ng/ml. Therapeutic limits (range) are most influenced by individual factors. Serum digoxin determination is especially necessary in patients with renal failure and in undisciplined patients with erratic digitalis intake. It is a useful aid in controlling the course of digitalis intoxication, in "low dosage" digitalization and in the case of possible drug interactions.

Topics: Arrhythmias, Cardiac; Digitalis Glycosides; Digoxin; Eye Manifestations; Gastrointestinal Diseases; Heart Failure; Humans; Patient Compliance

Topics: Animals; Aqueous Humor; Autoradiography; Binding Sites; Conjunctiva; Cornea; Digitalis Glycosides; Digoxin; Eye; Eye Manifestations; Freezing; Iris; Lens, Crystalline; Optic Nerve; Rats; Retina; Staining and Labeling; Tritium; Vitreous Body

Topics: Digitoxin; Digoxin; Eye Manifestations; Humans; Male; Middle Aged; Scotoma; Vision Disorders