digoxin and Carcinoma

digoxin has been researched along with Carcinoma* in 2 studies

Reviews

1 review(s) available for digoxin and Carcinoma

Article	Year
THE ROLE OF ADENOSINE TRIPHOSPHATE IN TRANSPORT REACTIONS. Canadian journal of biochemistry, 1964, Volume: 42 Topics: Adenosine Triphosphate; Amino Acids; Animals; Antimetabolites; Biological Transport; Carcinoma; Carcinoma, Ehrlich Tumor; Cell Membrane Permeability; Cerebral Cortex; Digoxin; Dinitrophenols; Glycine; Iodoacetates; Metabolism; Pharmacology; Rats; Research	1964

Other Studies

1 other study(ies) available for digoxin and Carcinoma

Article	Year
Effect of digoxin on DNA synthesis and cell viability in human breast tumour tissue in organ culture. Chemotherapy, 1983, Volume: 29, Issue:5 10 biopsy specimens of primary breast tumours from 10 patients were classified histopathologically into 8 ductal carcinomas and 2 lobular carcinomas. Portions of tumour of approximately 1 mm3 were cultured in Medium 199 buffered with 20 mM Hepes for 48 h with or without addition of digoxin at concentrations from 1-2 ng/ml to 10-20 micrograms/ml of culture medium. Measurement of DNA synthesis by [3H]-thymidine incorporation, DNA analysis and histological examination showed that 5 biopsy specimens demonstrated epithelial cell survival in culture. These cultures were significantly (p less than 0.001) affected by digoxin at concentrations above 10-20 ng/ml, with suppression of [3H]-thymidine incorporation and reduced epithelial cell viability. Parallel studies on 5 biopsy specimens of DMBA-induced rat mammary carcinomas showed no effects of digoxin up to 10 micrograms/ml of culture medium. These studies indicate the possibility of this class of drug being of use in growth suppression of breast tumours. Topics: Animals; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Cell Survival; Digoxin; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Humans; Organ Culture Techniques; Rats; Rats, Inbred Strains	1983

Article

Year

Effect of digoxin on DNA synthesis and cell viability in human breast tumour tissue in organ culture.

Chemotherapy, 1983, Volume: 29, Issue:5

10 biopsy specimens of primary breast tumours from 10 patients were classified histopathologically into 8 ductal carcinomas and 2 lobular carcinomas. Portions of tumour of approximately 1 mm3 were cultured in Medium 199 buffered with 20 mM Hepes for 48 h with or without addition of digoxin at concentrations from 1-2 ng/ml to 10-20 micrograms/ml of culture medium. Measurement of DNA synthesis by [3H]-thymidine incorporation, DNA analysis and histological examination showed that 5 biopsy specimens demonstrated epithelial cell survival in culture. These cultures were significantly (p less than 0.001) affected by digoxin at concentrations above 10-20 ng/ml, with suppression of [3H]-thymidine incorporation and reduced epithelial cell viability. Parallel studies on 5 biopsy specimens of DMBA-induced rat mammary carcinomas showed no effects of digoxin up to 10 micrograms/ml of culture medium. These studies indicate the possibility of this class of drug being of use in growth suppression of breast tumours.

Topics: Animals; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Cell Survival; Digoxin; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Humans; Organ Culture Techniques; Rats; Rats, Inbred Strains

1983