digoxin and Carcinoma--Ehrlich-Tumor

Topics: Adenosine Triphosphate; Amino Acids; Animals; Antimetabolites; Biological Transport; Carcinoma; Carcinoma, Ehrlich Tumor; Cell Membrane Permeability; Cerebral Cortex; Digoxin; Dinitrophenols; Glycine; Iodoacetates; Metabolism; Pharmacology; Rats; Research

Using the model of breast cancer Ehrlich ascites tumor in mice, we showed that a sigle intraperitoneal injection of cardiac glycoside digoxin 1 h before the intraperitoneal injection of cisplatin increased the anticancer effect of the cytostatic drug more than twice when recalculated for the dose. It is assumed that the modifying effect of digoxin is determined by the direct inhibition of glycolysis in tumor cells. Taking into account the design of the study, we consider promising the clinical evaluation of the effectiveness of digoxin as a modifier of cisplatin efficiency in intracavitary therapy of ascites cancers with pleural and abdominal dissenmination.

Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Cisplatin; Digoxin; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glycolysis; Mice, Inbred CBA; Neoplasm Transplantation; Treatment Outcome

Topics: Amino Acids; Animals; Autoradiography; Biological Transport, Active; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Line; Digitoxin; Digoxin; Drug Resistance; Glucosamine; Mice; Mitosis; Neuraminidase; Ouabain; Potassium; Potassium Isotopes; Ribonucleases; Sodium; Thymidine; Time Factors; Tritium; Uridine

Topics: Aldosterone; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Digitoxin; Digoxin; In Vitro Techniques; Mice; Prednisolone; Spironolactone; Thyroid Hormones; Tritium

Topics: Animals; Carcinoma, Ehrlich Tumor; Cardiac Glycosides; Digitoxin; Digoxin; Intestinal Absorption; Mice