digoxin and Altitude-Sickness

Forty subjects each were rapidly inducted by road to altitudes of 3200 and 3771 meters (m). Half of subjects at each altitude were maintained on digoxin and the other half received placebos. The digoxin group showed higher serum potassium at both altitudes. Serum sodium remained unaltered. When compared to control groups, urinary volume changes were less marked in the digoxin group. Similarly, the alterations in calcium and magnesium in serum and urine at 3771 m were less pronounced. However, none of these changes in the digoxin groups were statistically significant when compared with control groups.

Topics: Adult; Altitude; Altitude Sickness; Calcium; Digoxin; Humans; Hypoxia; Magnesium; Male; Medigoxin; Oliguria; Potassium; Sodium; Urine

Topics: Adrenal Cortex Hormones; Altitude; Altitude Sickness; Anti-Bacterial Agents; Diagnosis; Digoxin; Diuretics; Drug Therapy; Humans; Hypertension, Pulmonary; Morphine; Oxygen Inhalation Therapy; Pulmonary Edema