digitoxin and Vomiting

digitoxin has been researched along with Vomiting* in 33 studies

Reviews

2 review(s) available for digitoxin and Vomiting

ArticleYear
[Bradycardiac atrial fibrillation after consuming herbal tea].
    Deutsche medizinische Wochenschrift (1946), 1997, Jul-25, Volume: 122, Issue:30

    One day after drinking what she thought to be a tea made from borage leaves a 72-year-old woman developed nausea, vomiting and diarrhoea, later also flickering in her eyes and palpitations. She was in a good general state with a blood pressure of 120/75 mm Hg and an irregular heart rate of 52/min. Physical examination was otherwise unremarkable. She had not been on any medication.. The usual laboratory tests were normal. The electrocardiogram showed atrial fibrillation with a slow ventricular rate with pauses of up to 1.5s. intermittently type I and II 2 degrees AV block, and depressed concave ST segments. The level of digoxin was 3.93 ng/ml, that of digitoxin 133.5 ng/ml.. The patient's symptoms quickly improved under symptomatic treatment. Further questioning suggested that she had probably mistaken foxglove leaves for those of borage when picking them to make a brew.. If cardiac arrhythmias have occurred after intake of self-picked herbal leaves one should consider digitalis intoxication resulting from misidentification.

    Topics: Acute Disease; Aged; Atrial Fibrillation; Bradycardia; Diarrhea; Digitalis; Female; Humans; Plant Poisoning; Plants, Medicinal; Plants, Toxic; Tea; Vomiting

1997
Systemic plant poisoning in children.
    Pediatrics, 1974, Volume: 54, Issue:3

    Topics: Albumins; Alkaloids; Atropine; Atropine Derivatives; Basidiomycota; Charcoal; Child; Digitalis; Gastroenteritis; Humans; Mouth; Mushroom Poisoning; Nicotine; Phenytoin; Physostigmine; Plant Poisoning; Plants; Plants, Medicinal; Plants, Toxic; Poisons; Potassium Chloride; Renal Dialysis; Seizures; Toxins, Biological; Vomiting; Water-Electrolyte Balance

1974

Other Studies

31 other study(ies) available for digitoxin and Vomiting

ArticleYear
[A poisonous spring smoothie with wild herbs: accidental intoxication with foxglove (Digitalis purpurea)].
    Nederlands tijdschrift voor geneeskunde, 2020, 11-12, Volume: 164

    At a time when self-sufficiency and health are becoming increasingly important in society, the chances of intoxications with wild plants are increasing. Foxglove contains poisonous cardiac glycosides such as digoxin, digitoxin and gitoxin. The levels vary greatly and depend on the season and the location of the plants. The "non-digoxin" cardiac glycosides show a limited cross-reaction with the digoxin assay. This means that a low or therapeutic digoxin level does not rule out a severe foxglove intoxication. Due to the long half-life of the different cardiac glycosides, toxic symptoms can be persistent.. A 43-year-old woman arrived at the Emergency Department with persistent vomiting and specific ECG-abnormalities. The day before, she drunk a smoothie made from wild plants picked in the woods. Patient appeared to have mistaken foxglove for common sorrel.. In case of persistent gastrointestinal complaints with specific ECG abnormalities after ingestion of plant material, clinicians should be aware of a foxglove intoxication.

    Topics: Adult; Digitalis; Female; Foodborne Diseases; Humans; Vomiting

2020
Two cases of cardiac glycoside poisoning from accidental foxglove ingestion.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Jul-12, Volume: 188, Issue:10

    Topics: Aged; Antidotes; Arrhythmias, Cardiac; Digitalis; Digoxin; Electrocardiography; Female; Humans; Hyperkalemia; Male; Nausea; Vomiting

2016
Comfrey herbal remedy causing second-degree heart block: do not be outfoxed by digitalis.
    BMJ case reports, 2016, Dec-01, Volume: 2016

    A previously well woman aged 63 years presents to the emergency department with vomiting, palpitations and 3 presyncopal episodes. She had no previous medical or cardiac history, with the patient stating that she tried a herbal remedy of boiled comfrey leaves for insomnia 18 hours before arrival to the department. Her ECG showed multiple abnormalities, including bradycardia, second-degree atrioventricular node block, Mobitz Type 2, a shortened QT interval, downsloping ST depression and presence of U waves. After viewing the images of comfrey and foxglove, it highlighted the possibility of mistaken ingestion of Digitalis, containing the organic forms of cardiac glycosides, such as digoxin and digitoxin. Raised serum digoxin levels confirmed this. The patient was haemodynamically stable, and given digoxin-binding antibodies. After 5 days of cardiac monitoring, her ECG returned to normal rhythm, and she was discharged home.

    Topics: Accidents; Antibodies, Heterophile; Atrioventricular Block; Bradycardia; Comfrey; Digitalis; Digoxin; Electrocardiography; Female; Humans; Middle Aged; Plant Leaves; Plant Poisoning; Plants, Medicinal; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Vomiting

2016
[EKG-changes with gastrointestinal disorder].
    Deutsche medizinische Wochenschrift (1946), 2011, Volume: 136, Issue:20

    Topics: Anti-Arrhythmia Agents; Bradycardia; Diagnosis, Differential; Digitoxin; Dose-Response Relationship, Drug; Electrocardiography; Electrocardiography, Ambulatory; Female; Humans; Middle Aged; Nausea; Signal Processing, Computer-Assisted; Sinus Arrest, Cardiac; Syncope; Vomiting

2011
Plant poisonings: common plants that contain cardiac glycosides.
    Journal of emergency nursing, 2011, Volume: 37, Issue:1

    Topics: Bradycardia; Cardiac Glycosides; Child, Preschool; Digitalis; Emergency Treatment; Female; Humans; Male; Middle Aged; Nerium; Plant Poisoning; Vomiting

2011
ECG for physicians: a potentially fatal case of mistaken identity.
    Resuscitation, 2008, Volume: 76, Issue:3

    Topics: Adult; Atrioventricular Block; Bradycardia; Comfrey; Digitalis; Digoxin; Dizziness; Electrocardiography; Humans; Male; Nausea; Phytotherapy; Plant Leaves; Vision Disorders; Vomiting

2008
Clinical problem-solving. A bitter tale.
    The New England journal of medicine, 2004, Aug-05, Volume: 351, Issue:6

    Topics: Bradycardia; Diagnosis, Differential; Digitalis; Digitoxin; Digoxin; Electrocardiography; Female; Humans; Middle Aged; Nausea; Plant Poisoning; Syncope; Vomiting

2004
Emesis and space motion sickness in amphibians.
    Advances in space research : the official journal of the Committee on Space Research (COSPAR), 2000, Volume: 25, Issue:10

    Amphibians possess the ability to vomit in response to a variety of stimuli that provoke emesis in mammals. Pharmacological studies have establish that the ejection of gastric contents and the basic mechanism for vomiting have been phylogenetically conserved among these tetrapods. As part of on-going comparative studies on emesis in vertebrates, we previously documented that some postmetamorphic anurans and salamander larvae experience motion-induced emesis when exposed to the provocative stimulus of parabolic aircraft flight. However, more recent experiments suggest that there are strict conditions for inducing emesis in amphibians exposed to parabolic flight and that amphibians are not as sensitive to this stimulus as mammals. Further studies on emesis in lower vertebrates may help us understand the processes that cause emesis in abnormal gravitational regimes.

    Topics: Amphibians; Animals; Anura; Apomorphine; Cisplatin; Digitoxin; Emetics; Hypergravity; Ouabain; Reproducibility of Results; Space Flight; Space Motion Sickness; Urodela; Vomiting; Weightlessness

2000
Cardiovascular activity of a methanolic extract of Digitalis purpurea spp. heywoodii.
    Journal of ethnopharmacology, 2000, Volume: 71, Issue:3

    The paper deals with the effects of a glycosidal extract of Digitalis heywoodii, ssp. of Digitalis purpurea L., (Schrophulariaceae) grown in Badajoz (Spain), on isolated cardiac auricle of rabbits, urinary excretion of rats, as well as its emetic effect in pigeons. These effects using vehicle (propylene glycol-ethanol-water, 40:10:50) and digoxin as standards are presented. The extract at concentrations of 20 and 40 microg/ml produced an increase in the contraction force of auricles in a dose-dependent way. At doses of 15 and 30 mg/kg a slight diuretic and natriuretic effect was observed. The active dose range for emesis was 0.5-4 mg/kg and a decrease of the emesis time within 10 min of injection in dose-dependent manner was obtained. The pharmacological activity of the extract is related to gitoxin derivatives (digitalinum verum and strospeside), the most abundant compounds obtained from the leaves of Digitalis purpurea spp. heywoodii.

    Topics: Animals; Columbidae; Digitalis; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Plant Extracts; Rabbits; Rats; Vomiting

2000
Contamination of botanical dietary supplements by Digitalis lanata.
    The New England journal of medicine, 1998, Sep-17, Volume: 339, Issue:12

    Topics: Adult; Dietary Supplements; Digitalis; Digoxin; Drug Contamination; Female; Heart Block; Humans; Lanatosides; Middle Aged; Plantago; Plants, Medicinal; Plants, Toxic; Vomiting

1998
Involvement of a peripheral mechanism in the emesis induced by cardiac glycosides in Suncus murinus.
    Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:5

    The ability of three cardiac glycosides, ouabain, digitonin and digitoxin, to induce emesis and their mechanism(s) of action were investigated in Suncus murinus. The intraperitoneal injection of ouabain but not digitonin nor digitoxin caused vomiting in a dose-dependent manner. However, the administration of ouabain into the cerebroventricle did not cause emesis. Ouabain-induced emesis was partly prevented by surgical abdominal vagotomy. Pretreatment with tropisetron, a selective 5-HT3 (5-hydroxytriptamine) receptor antagonist, did not affect the emetic response evoked by ouabain. These results suggest that ouabain exerts emetic effects via peripheral mechanism(s), but 5-HT3 receptors are not involved in the pathway.

    Topics: Animals; Antiemetics; Cardiac Glycosides; Digitonin; Digitoxin; Female; Indoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Ouabain; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Shrews; Tropisetron; Vagotomy; Vomiting

1997
[Reversible thrombocytopenia due to digitoxin overdose].
    Deutsche medizinische Wochenschrift (1946), 1994, Dec-16, Volume: 119, Issue:50

    A 65-year-old woman, known to have peptic ulcers, developed nausea and retching. Clinical examination demonstrated pain on pressure in the epigastrium with otherwise normative findings for age. Two gastric ulcers and gastritis with erosions were seen at endoscopy. The patient, who was being treated with digitoxin for heart failure, reported having taken up to four digitoxin tablets (0.07 mg each) daily because she had insomnia. The plasma digitoxin level was between 150 and 160 nmol/l (therapeutic range 17-33 nmol/l), while the ECG showed no signs of digitalis intoxication. Initially the platelet count was 40,000/microliter: there had been no history of thrombocytopenia or symptoms of abnormal haemostasis. Other laboratory tests were within normal limits. After digitoxin had been discontinued, the platelet count rose without further treatment to 373,000/microliter 3 weeks after hospital admission by which time the digitoxin level had fallen to 48.9 nmol/l. The gastrointestinal symptoms regressed completely on treatment with omeprazole (40 mg three times daily for 8 days) and ranitidine (150 mg twice daily).

    Topics: Aged; Digitoxin; Drug Overdose; Female; Gastritis; Gastroscopy; Heart Failure; Humans; Nausea; Omeprazole; Platelet Count; Ranitidine; Stomach Ulcer; Thrombocytopenia; Vomiting

1994
Plasma concentrations of digoxin and digitoxin during digitalization of healthy dogs and dogs with cardiac failure.
    American journal of veterinary research, 1978, Volume: 39, Issue:5

    Topics: Administration, Oral; Animals; Digitoxin; Digoxin; Dog Diseases; Dogs; Female; Heart Failure; Male; Vomiting

1978
Fever, vomiting, and liver dysfunction with procainamide therapy.
    Postgraduate medicine, 1974, Volume: 56, Issue:1

    Topics: Ampicillin; Blood; Chemical and Drug Induced Liver Injury; Digitalis; Drug Hypersensitivity; Female; Fever; Furosemide; Humans; Lidocaine; Middle Aged; Myocardial Infarction; Phytotherapy; Plants, Medicinal; Plants, Toxic; Procainamide; Quinidine; Urine; Vomiting

1974
The use of metoclopramide in the elderly.
    Postgraduate medical journal, 1973, Volume: 49 Suppl 4

    Topics: Aged; Digitalis; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Geriatrics; Hiccup; Humans; Influenza, Human; Metoclopramide; Morphine; Nausea; Plants, Medicinal; Plants, Toxic; Vomiting

1973
A clinical profile of idiopathic atrial fibrillation. A functional disorder of atrial rhythm.
    Annals of internal medicine, 1968, Volume: 68, Issue:6

    Topics: Adolescent; Adult; Alcoholic Beverages; Atrial Fibrillation; Blood Glucose; Blood Pressure Determination; Body Weight; Cough; Diet; Digitoxin; Electric Countershock; Electrocardiography; Emotions; Fatigue; Female; Heart; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pain; Posture; Quinidine; Radiography; Rest; Thyroid Function Tests; Vagus Nerve; Vomiting

1968
[On strophanthin therapy. Advantages and disadvantages].
    Deutsche medizinische Wochenschrift (1946), 1967, Sep-08, Volume: 92, Issue:36

    Topics: Angina Pectoris; Coronary Disease; Digitalis; Heart Conduction System; Heart Diseases; Humans; Nausea; Plants, Medicinal; Plants, Toxic; Strophanthins; Vomiting

1967
A DIGITALIS-LIKE TOXIN IN THE MONARCH BUTTERFLY, DANAUS PLEXIPPUS L.
    The Journal of physiology, 1965, Volume: 178

    Topics: Animals; Antitoxins; Anura; Birds; Butterflies; Cats; Chemistry Techniques, Analytical; Digitalis; Digitalis Glycosides; Erythrocytes; Guinea Pigs; Heart; Ileum; Insecta; Isoflurophate; Pharmacology; Research; Toxicology; Toxins, Biological; Vomiting

1965
REVERSAL OF DIGITALIS INTOXICATION BY BETA-ADRENERGIC BLOCKADE WITH PRONETHALOL.
    The New England journal of medicine, 1964, Oct-22, Volume: 271

    Topics: Adrenergic Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Digitalis; Digoxin; Electrocardiography; Ethanolamines; Geriatrics; Heart Block; Heart Failure; Hypotension; Myocardial Infarction; Nausea; Paresthesia; Sympatholytics; Toxicology; Vertigo; Vomiting

1964
[ON THE TREATMENT OF NAUSEA DUE TO DIGITALIS INTAKE].
    Arztliche Forschung, 1964, Apr-10, Volume: 18

    Topics: Antiemetics; Digitalis; Digitalis Glycosides; Humans; Nausea; Toxicology; Vomiting

1964
[Prochlorperazine in therapy of nausea and vomiting in patients of heart disease after digitalis therapy].
    Minerva medica, 1959, Jun-02, Volume: 50, Issue:44

    Topics: Barbiturates; Digitalis; Heart Diseases; Humans; Nausea; Prochlorperazine; Vomiting

1959
Delayed vomiting induced in dogs by intramuscular digoxin.
    The Journal of pharmacy and pharmacology, 1959, Volume: 11

    Topics: Animals; Digitalis; Digoxin; Dogs; Injections, Intramuscular; Plant Extracts; Vomiting

1959
[Effect of chlorpromazine on the emetic action and toxicity of digitalis].
    Archives internationales de pharmacodynamie et de therapie, 1956, Jan-01, Volume: 104, Issue:3-4

    Topics: Chlorpromazine; Digitalis; Digitalis Glycosides; Drug-Related Side Effects and Adverse Reactions; Emetics; Plant Extracts; Vomiting

1956
[Effects of chlorpromazine on the vomiting mechanism in pigeons].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1956, Volume: 228, Issue:1-2

    Topics: Animals; Apomorphine; Chlorpromazine; Columbidae; Digitalis; Digitalis Glycosides; Vomiting

1956
[Cumulation of the pure glycosides digoxin, digitoxin and Boviea extract; studies on the basis of emetic dosage in pigeon].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1953, Volume: 220, Issue:4

    Topics: Animals; Cardiac Glycosides; Columbidae; Digitalis; Digitalis Glycosides; Digitoxin; Digoxin; Emetics; Glycosides; Humans; Plant Extracts; Vomiting

1953
[Effect of novocaine and ganglion blocking agents on the reflex toxic effects of digitalis; bradycardia and vomiting].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1953, Volume: 218, Issue:3

    Topics: Bradycardia; Digitalis; Digitalis Glycosides; Ganglionic Blockers; Procaine; Reflex; Vomiting

1953
[Effect of ganglion blocking agents, spasmolytics and novocaine on pharmacologically-induced vomiting reactions].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1953, Volume: 218, Issue:3

    Topics: Autonomic Agents; Digitalis; Digitalis Glycosides; Ganglionic Blockers; Muscle Relaxants, Central; Parasympatholytics; Procaine; Vomiting

1953
[Pharmacological effect on the reflex-toxic response of cardiac nerves to digitalis].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1953, Volume: 220, Issue:3

    Topics: Autonomic Agents; Autonomic Nervous System; Bradycardia; Digitalis; Digitalis Glycosides; Diphenhydramine; Neurocirculatory Asthenia; Reflex; Tetraethylammonium; Vomiting

1953
Role of gastrointestinal innervation in digitalis emesis.
    The Journal of pharmacology and experimental therapeutics, 1952, Volume: 104, Issue:4

    Topics: Digitalis; Humans; Vomiting

1952
[Effect of dramamine on vomiting due to digitalis poisoning in man].
    Archivos del Instituto de Cardiologia de Mexico, 1950, Volume: 20, Issue:5-6

    Topics: Cardiovascular Agents; Digitalis; Digitalis Glycosides; Dimenhydrinate; Humans; Vomiting

1950
Relationship of carotid and aortic mechanisms to digitalis emesis.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1946, Volume: 61

    Topics: Aorta; Cardiovascular System; Digitalis; Digitalis Glycosides; Humans; Vomiting

1946