digitoxin and Seizures

Topics: Albumins; Alkaloids; Atropine; Atropine Derivatives; Basidiomycota; Charcoal; Child; Digitalis; Gastroenteritis; Humans; Mouth; Mushroom Poisoning; Nicotine; Phenytoin; Physostigmine; Plant Poisoning; Plants; Plants, Medicinal; Plants, Toxic; Poisons; Potassium Chloride; Renal Dialysis; Seizures; Toxins, Biological; Vomiting; Water-Electrolyte Balance

In three experiments, behavioral toxicity induced by 5 different dose levels of digitoxin was investigated in mice that were treated with either clonidine or propranolol or were either young (70-140 days), middle aged (240-260) or old (450-600). Observed on four drug-induced behavior categories, it was found that both clonidine and propranolol attenuated the toxic effects of relatively low dose levels of digitoxin, while at higher digitoxin dose levels only propranolol was able to reduce significantly the ED50 and the LD50. The results were discussed in terms of adrenergic mechanisms mediating digitoxin toxicity. Aged mice were found to be the least and middle aged the most resistant to the toxic effects of digitoxin.

Topics: Aging; Animals; Behavior, Animal; Clonidine; Digitoxin; Drug Interactions; Gait; Male; Mice; Postural Balance; Propranolol; Seizures; Time Factors; Tremor

Zoxazolamine paralysis, hexobarbital anesthesia and digitoxin convulsions were diminished in rats by 3 days of pretreatment with pregnenolone-16alpha-carbonitrile (PCN). Simultaneous injection of dl-ethionine did not block this effect of PCN. Dl-Ethionine decreased, while PCN or PCN + ethionene increased, zoxazolamine metabolism by the 9,000g supernatant fraction of the liver. Dl-ethionine neutralized the influence of PCN and phenobarbital on zoxazolamine metabolism in rats that were pretreated with PCN or phenobarbital for 1 day, and it inhibited the action of phenobarbital on hexobarbital anesthesia. PCN augmented the liver weight of animals given dl-ehtionine whereas dl-ethionine in itself did not. PCN produced SER proliferation in hepatocytes and dl-ethionine caused lipid accumulation, SER proliferation and myelin-figure formation. When administered conjointly, these compounds had an additive effect on the liver cell ultrastructure.

Topics: Animals; Digitoxin; Drug Interactions; Ethionine; Female; Hexobarbital; In Vitro Techniques; Liver; Microscopy, Electron; Paralysis; Pharmaceutical Preparations; Phenobarbital; Pregnenolone Carbonitrile; Rats; Seizures; Sleep; Zoxazolamine

Topics: Animals; Behavior, Animal; Cardiac Glycosides; Cerebral Ventricles; Depression, Chemical; Digitoxin; Digoxin; Electrocardiography; Heart; Heart Rate; Injections; Injections, Intravenous; Lethal Dose 50; Mice; Ouabain; Respiration; Seizures

Topics: Anabolic Agents; Androstanes; Animals; Bufanolides; Digitoxin; Ethylestrenol; Female; Glucocorticoids; Hydroxysteroids; Ketosteroids; Phenobarbital; Pregnanes; Pregnenolone; Propionates; Rats; Rats, Inbred Strains; Seizures; Spironolactone; Thyroxine

Topics: Animals; Digitoxin; Drug Antagonism; Enzyme Induction; Liver; Male; Mice; Paralysis; Pentobarbital; Seizures; Sleep; Spironolactone; Time Factors; Zoxazolamine

Topics: Animals; Digitoxin; Female; Indomethacin; Intestine, Small; Nitriles; Peritonitis; Poisoning; Pregnenolone; Rats; Seizures; Spironolactone

Topics: Animals; Digitoxin; Drug Antagonism; Female; Indomethacin; Intestinal Diseases; Jejunum; Microsomes, Liver; Mortality; Oxandrolone; Proadifen; Rats; Seizures; Spironolactone; Ulcer

Topics: Acetates; Animals; Brain; Caudate Nucleus; Digitoxin; Electroencephalography; Ethacrynic Acid; Female; Geniculate Bodies; Hippocampus; Hypothalamus; Male; Mercury; Ouabain; Rabbits; Reticular Formation; Seizures; Thalamus

Topics: Adult; Age Factors; Animals; Animals, Newborn; Cats; Central Nervous System Stimulants; Cerebral Cortex; Circadian Rhythm; Conditioning, Classical; Depression, Chemical; Digitoxin; Electroencephalography; Evoked Potentials; Glycosides; Humans; Locomotion; Panax; Plant Extracts; Plants, Medicinal; Rats; Reserpine; Seasons; Seizures

Topics: Animals; Behavior, Animal; Diazoxide; Digitoxin; Diuretics; Drinking; Ethacrynic Acid; Furosemide; Hydrochlorothiazide; Hypothalamus; Injections, Intraperitoneal; Injections, Intravenous; Kidney; Male; Nephrectomy; Rats; Seizures; Sodium Chloride; Thirst; Water

Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Digitalis; Heart Block; Heart Conduction System; Humans; Potassium; Seizures; Tachycardia; Tachycardia, Ventricular; Ventricular Fibrillation