digitoxin and Mitral-Valve-Insufficiency

Atrial and ventricular arrhythmias were characterized by ambulatory electrocardiography in 31 patients with nonischemic mitral regurgitation (MR), 17 of whom had echocardiographic evidence of mitral valve prolapse (MVP) and 14 of whom had other causes of MR. Frequent and complex arrhythmias were common and equally prevalent in each MR subgroup, whether or not MVP was present. Multiform ventricular ectopy was found in 77% (24 of 31), ventricular couplets in 61% (19 of 31), and ventricular salvos or ventricular tachycardia in 35% (11 of 31) of patients with MR. Arrhythmias in patients with MR were significantly more prevalent than in 63 patients with MVP who had no evidence of MR. Among patients with MVP, excess arrhythmias associated with MR were most striking with respect to frequent ventricular premature complexes (41% with MR vs 3% without MR), multiform ventricular ectopic activity (88% vs 43%), ventricular couplets (65% vs 6%), and ventricular salvos or ventricular tachycardia (35% vs 5%) (p less than 0.005 for each comparison). These data demonstrate that complex arrhythmias are common in patients with nonischemic MR irrespective of etiology, and that these arrhythmias are more strongly associated with hemodynamically important MR than with MVP alone.

Topics: Adult; Aged; Arrhythmias, Cardiac; Cineangiography; Digitalis; Echocardiography; Electrocardiography; Female; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Mitral Valve Prolapse; Plants, Medicinal; Plants, Toxic

Topics: Blood Proteins; Blood Urea Nitrogen; Digitalis Glycosides; Digitoxin; Diuretics; Electrolytes; Heart; Heart Failure; Heart Valve Diseases; Humans; Mitral Valve Insufficiency; Mitral Valve Stenosis; Radiography; Rheumatic Heart Disease

Topics: Adult; Aortic Valve Insufficiency; Atrial Fibrillation; Bicarbonates; Blood Proteins; Body Composition; Body Water; Body Weight; Bromine; Cardiac Complexes, Premature; Chlorides; Creatinine; Digitalis; Diuretics; Female; Heart Diseases; Heart Failure; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Phytotherapy; Plants, Medicinal; Plants, Toxic; Potassium; Potassium Chloride; Potassium Isotopes; Sodium; Sodium Isotopes; Spironolactone; Tachycardia

Topics: Antihypertensive Agents; Bloodletting; Bronchodilator Agents; Digitalis; Digoxin; Furosemide; Heart Failure; Heroin; Hospitalization; Humans; Intensive Care Units; Mitral Valve Insufficiency; Mitral Valve Stenosis; Morphine; Oxygen Inhalation Therapy; Phytotherapy; Plants, Medicinal; Plants, Toxic; Positive-Pressure Respiration; Posture; Pulmonary Edema; Respiration, Artificial; Tourniquets; Venous Pressure

Topics: Adult; Aged; Aortic Valve Insufficiency; Aortic Valve Stenosis; Arrhythmia, Sinus; Atrial Fibrillation; Cardiac Volume; Digitalis; Electric Countershock; Electrocardiography; Female; Heart Atria; Humans; Male; Methods; Middle Aged; Mitral Valve Insufficiency; Mitral Valve Stenosis; Plants, Medicinal; Plants, Toxic

Topics: Aged; Atrial Fibrillation; Cardiomyopathies; Diagnosis, Differential; Digitalis; Electrocardiography; Geriatrics; Heart Diseases; Heart Failure; Heart Valve Diseases; Humans; Hypertension; Ischemia; Mitral Valve Insufficiency; Phytotherapy; Plants, Medicinal; Plants, Toxic; Ventricular Fibrillation

Topics: Aged; Aortic Valve Insufficiency; Digitoxin; Digoxin; Ethacrynic Acid; Female; Furosemide; Heart Failure; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Oxygen Inhalation Therapy; Pulmonary Heart Disease; Spironolactone

Topics: Adolescent; Cardiac Complexes, Premature; Digitalis; Electrocardiography; Female; Heart Atria; Heart Failure; Humans; Middle Aged; Mitral Valve Insufficiency; Phytotherapy; Plants, Medicinal; Plants, Toxic

Topics: Atrial Fibrillation; Coronary Disease; Digitalis Glycosides; Digitoxin; Electrocardiography; Female; Heart Failure; Humans; Hypertension; Male; Middle Aged; Mitral Valve Insufficiency; Rheumatic Heart Disease; Time Factors

Topics: Digitalis; Digitalis Glycosides; Hemodynamics; Humans; Mitral Valve Insufficiency; Mitral Valve Stenosis

Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Brugada Syndrome; Cardiac Conduction System Disease; Cardiac Surgical Procedures; Digitoxin; Drug Therapy; Heart Block; Heart Conduction System; Humans; Mitral Valve Insufficiency; Mitral Valve Stenosis; Postoperative Complications; Rauwolfia; Tachycardia; Tachycardia, Paroxysmal; Thoracic Surgery

Topics: Adrenal Medulla; Catecholamines; Digitalis; Digitalis Glycosides; Epinephrine; Heart; Heart Diseases; Heart Failure; Humans; Mitral Valve Insufficiency; Mitral Valve Stenosis; Natriuresis; Norepinephrine; Pericarditis; Strophanthins; Urination; Urine

Topics: Aortic Diseases; Aortic Valve Stenosis; Arteriosclerosis; Digitalis; Digitalis Glycosides; Glucosephosphates; Heart Failure; Hexosephosphates; Humans; Mitral Valve Insufficiency; Mitral Valve Stenosis; Pulmonary Heart Disease

Topics: Adolescent; Aortic Valve Stenosis; Arrhythmias, Cardiac; Biomedical Research; Digitalis; Digitalis Glycosides; Drug Therapy; Drug Tolerance; Electrocardiography; Humans; Mitral Valve Insufficiency; Mitral Valve Stenosis; Rheumatic Heart Disease; Sex; Toxicology

Topics: Angina Pectoris; Aortic Valve Stenosis; Digitalis; Digitalis Glycosides; Drug Therapy; Electrocardiography; Exercise Test; Heart Septal Defects; Heart Septal Defects, Atrial; Hematocrit; Humans; Hypertension; Mitral Valve Insufficiency; Myocardial Infarction; Polycythemia Vera; Postoperative Care; Potassium; Tachycardia; Tachycardia, Paroxysmal; Water-Electrolyte Balance

Topics: Arteriosclerosis; Atrial Fibrillation; Digitalis; Digitalis Glycosides; Geriatrics; Gynecomastia; Humans; Male; Mastectomy; Mitral Valve Insufficiency; Pathology; Rheumatic Heart Disease; Toxicology