digitoxin and Hyperthyroidism

Topics: Digitalis Glycosides; Digitoxin; Digoxin; Drug Interactions; Heart Failure; Humans; Hyperthyroidism; Hypothyroidism; Intestinal Absorption; Kidney Failure, Chronic; Molecular Conformation; Obesity

Topics: Adult; Aged; Arteriosclerosis; Body Weight; Clinical Trials as Topic; Diet, Sodium-Restricted; Digitoxin; Diuresis; Electrocardiography; Heart Conduction System; Heart Failure; Humans; Hyperthyroidism; Injections, Intravenous; Middle Aged; Myocardial Infarction

In a comparative prospective study the serum levels of digoxin and digitoxin and the glomerular filtration of the kidneys were determined radioimmunologically in thyroid function disorders using the endogenous creatinine clearance and the 51Cr-EDTA clearance. Compared to a euthyroid control group 17 patients with hyperthyroidism showed a decreased and 5 patients with hypothyroidism showed a largely toxic digoxin level, both groups being on a maintenance therapy of 0.25 mg digoxin b. i. d. During an oral maintenance therapy of daily 0.1 mg digitoxin unchanged therapeutic serum levels were found in 35 hyperthyroid and 18 hypothyroid patients when compared to a euthyroid control group. Assessment of clearances showed that glomerular filtration rates were clearly increased in the hyperthyroid and lowered in the hypothyroid patients. Renewed assessment of the clearance in four hyperthyroid patients and three with hypothyroidism after thyroid recompensation showed a marked decrease of clearance values in hyperthyroidism and an increase in hypothyroidism. Increased clearance values in hyperthyroidism were associated with lowered digoxin serum levels. In contrast, lowered clearance values in hypothyroidism were accompanied by increased serum digoxin levels. There was no such association detectable for digitoxin.

Topics: Adult; Aged; Creatinine; Digitoxin; Digoxin; Glomerular Filtration Rate; Humans; Hyperthyroidism; Hypothyroidism; Middle Aged

Topics: Adrenergic beta-Antagonists; Digitalis Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Heart Failure; Humans; Hyperthyroidism; Kidney Failure, Chronic; Liver Diseases; Quinidine

A significant positive correlation between heart weight and adrenal weight was found in rats with myocardial hypertrophy induced by experimental hyperthyroidism or ligation of the abdominal aorta. The simultaneous administration of digitoxin partly inhibited myocardial hypertrophy after ligation of the abdominal aorta, but not after experimental hyperthyroidism. Digitoxin also inhibited adrenal hypertrophy after ligature of the abdominal aorta but, again, not after experimental hyperthyroidism. The possible existence of an endogenous cardiotropic hormone participating in the development of cardiac hypertrophy from overloading is discussed.

Topics: Adrenal Glands; Animals; Aorta, Abdominal; Cardiomegaly; Digitoxin; Hyperthyroidism; Ligation; Male; Myocardium; Organ Size; Rats; Rats, Inbred Strains; Thyroid Hormones

Topics: Administration, Oral; Aged; Arrhythmias, Cardiac; Digitalis Glycosides; Digitoxin; Digoxin; Heart Block; Heart Diseases; Heart Failure; Humans; Hyperthyroidism; Injections, Intravenous; Kidney Failure, Chronic; Middle Aged; Obesity; Ventricular Fibrillation

Topics: Aminoglycosides; Anesthesia; Animals; Betamethasone; Digitoxin; Drug Antagonism; Drug Synergism; Fusidic Acid; Hyperthyroidism; Hypothyroidism; Male; Neuromuscular Junction; Norethandrolone; Pancuronium; Rats; Steroids

Topics: Digitoxin; Electrocardiography; Female; Growth Disorders; Heart Atria; Heart Failure; Humans; Hyperthyroidism; Infant, Newborn; Long-Acting Thyroid Stimulator; Male; Maternal-Fetal Exchange; Pregnancy; Tachycardia, Paroxysmal; Thyrotropin

Topics: Adult; Aged; Antithyroid Agents; Digitoxin; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Ouabain; Thyroid Function Tests; Thyroid Hormones; Tritium

Topics: Atrial Fibrillation; Digitoxin; Female; Heart Failure; Humans; Hyperthyroidism; Iatrogenic Disease; Middle Aged; Tachycardia

Topics: Animals; Aortic Valve Insufficiency; Aortic Valve Stenosis; Body Weight; Columbidae; Coronary Disease; Digitoxin; Heart Failure; Heart Rate; Heart Septal Defects, Atrial; Humans; Hypertension; Hyperthyroidism; Mitral Valve Stenosis; Pericarditis, Constrictive; Pulmonary Heart Disease

Topics: Blood Flow Velocity; Brain; Carbon Dioxide; Cerebral Arteries; Cerebrovascular Circulation; Digitalis; Humans; Hyperthyroidism; Hypotension; Intracranial Arteriosclerosis; Norepinephrine; Oxygen Consumption; Plants, Medicinal; Plants, Toxic; Regional Blood Flow; Vasodilator Agents

Topics: Diet; Diet Therapy; Digitalis; Digitalis Glycosides; Diuretics; Electrocardiography; Heart Failure; Humans; Hyperthyroidism; Hypokalemia; Hyponatremia; Radiography, Thoracic

Topics: Angina Pectoris; Atrial Fibrillation; Digitalis; Digitalis Glycosides; Heart Failure; Humans; Hyperthyroidism; Iodine Isotopes; Morbidity; Mortality; Tachycardia; Tachycardia, Paroxysmal

Topics: Coronary Disease; Digitalis; Digitalis Glycosides; Heart Diseases; Heart Failure; Heart Valve Diseases; Hypertension; Hypertension, Pulmonary; Hyperthyroidism; Pharmacology; Toxicology; Ventricular Fibrillation

Topics: Digitalis; Digitalis Glycosides; Digoxin; Heart; Heart Failure; Humans; Hyperthyroidism

Topics: Anemia; Coronary Disease; Diagnosis, Differential; Digitalis; Digitalis Glycosides; Geriatrics; Heart Failure; Humans; Hyperthyroidism; Lung Diseases; Myxedema; Nephrosis; Pulmonary Embolism; Rheumatic Heart Disease; Water-Electrolyte Balance

Topics: Action Potentials; Barbiturates; Calcium; Digitalis; Digitalis Glycosides; Digitoxigenin; Guinea Pigs; Heart Atria; Heart Failure; Hyperthyroidism

Topics: Action Potentials; Barbiturates; Calcium; Calcium Metabolism Disorders; Digitalis; Digitalis Glycosides; Digitoxigenin; Guinea Pigs; Heart Atria; Heart Failure; Hyperthyroidism

Topics: Digitalis; Digitalis Glycosides; Humans; Hyperthyroidism; Physical Examination; Plant Extracts

Topics: Biological Transport; Cholesterol; Digitalis; Humans; Hyperthyroidism; Hypothyroidism; Sterols

Topics: Digitalis; Digitalis Glycosides; Health Services; Heart; Hyperthyroidism; Thyroid Gland