digitoxin and Hemolysis

digitoxin has been researched along with Hemolysis* in 8 studies

Other Studies

8 other study(ies) available for digitoxin and Hemolysis

ArticleYear
A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products.
    Journal of natural products, 2002, Volume: 65, Issue:1

    A multitarget functional bioassay was optimized as a method for detecting substances interacting with the inflammatory process of activated neutrophil granulocytes, mainly to release elastase detected by p-nitroanilide (pNA) formation. Using this bioassay, 100 fractionated extracts of 96 plants were screened, with results presented in a manner that links recorded biological activity to phylogenetic information. The plants were selected to represent a major part of the angiosperms, with emphasis on medicinal plants, Swedish anti-inflammatory plants, and plants known to contain peptides. Of the tested extracts, 41% inhibited pNA formation more than 60%, and 3% stimulated formation. The extract of Digitalis purpurea enhanced pNA formation, and digitoxin, the active compound, was isolated and identified. Plant extracts that exhibited potent nonselective inhibition (>80% inhibition) were evaluated further for direct inhibition of isolated elastase and trypsin enzyme. The inhibitory effect of most tested extracts on the isolated enzyme elastase was similar to that of PAF- and fMLP-induced pNA formation. Compared to trypsin, inhibition of elastase by extracts of Rubus idaeus and Tabernaemontana dichotoma was significantly higher (80% and 99%, respectively). Inhibition of trypsin by the extract of Reseda luteola was high (97%). Orders such as Lamiales and Brassicales were shown to include a comparably high proportion of plants with inhibitory extracts.

    Topics: alpha-Amylases; Anti-Inflammatory Agents; Benzoylarginine Nitroanilide; Biological Assay; Biological Products; Cytochalasin B; Digitalis; Digitonin; Digitoxin; Dose-Response Relationship, Immunologic; Hemolysis; Humans; Lamiaceae; Leukocyte Elastase; Magnoliopsida; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Peptides; Plant Proteins; Plants, Medicinal; Platelet Activating Factor; Superoxides; Sweden; Tabernaemontana; Trypsin Inhibitors; Violaceae

2002
[Adverse effects of rifampicin and their biochemical principles].
    Deutsche medizinische Wochenschrift (1946), 1975, Jan-10, Volume: 100, Issue:2

    Topics: Acute Disease; Acute Kidney Injury; Anticoagulants; Contraceptives, Oral; Digitoxin; Female; Hemolysis; Humans; Nephritis, Interstitial; Rifampin; Thrombocytopenia; Tuberculosis

1975
STUDIES ON THE HEMOLYTIC NATURE OF PROTEIN-DEFICIENCY ANEMIA IN THE RAT.
    Blood, 1964, Volume: 24

    Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Blood Proteins; Cell Membrane Permeability; Cholesterol; Citrates; Digitalis; Erythrocytes; Hemolysis; Heparin; Leukopenia; Lipids; Osmosis; Pharmacology; Protein Deficiency; Rats; Research; Saponins

1964
[Reaction of reduced glutathione in dependence on time factor in experimental hemolysis].
    Arztliche Wochenschrift, 1957, Sep-13, Volume: 12, Issue:37

    Topics: Bile Acids and Salts; Cell Death; Digitalis; Digitalis Glycosides; Glutathione; Hemolysis; Plant Extracts; Salts; Saponins; Time Factors

1957
[Problem of the mechanism of digitonin hemolysis].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1955, Volume: 225, Issue:6

    Topics: Cell Death; Digitalis; Digitalis Glycosides; Digitonin; Hemolysis; Plant Extracts

1955
[Morphological differentiation of hemolysis by the bee and snake venom, lysocithin and digitonin].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1954, Volume: 223, Issue:3

    Topics: Animals; Bees; Cell Death; Cell Differentiation; Digitalis; Digitalis Glycosides; Digitonin; Hemolysis; Lecithins; Phosphatidylcholines; Plant Extracts; Snake Venoms; Venoms

1954
[The nature of digitonin hemolysis].
    Helvetica physiologica et pharmacologica acta, 1952, Volume: 10, Issue:4

    Topics: Cell Death; Digitalis; Digitalis Glycosides; Digitonin; Hemolysis; Plant Extracts

1952
[Irreversibility of digitonincholesterol binding in digitonin hemolysis].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1951, Volume: 287, Issue:3-6

    Topics: Cholesterol; Digitalis; Digitalis Glycosides; Digitonin; Glycosides; Hemolysis; Humans; Plant Extracts

1951