digitoxin and Fractures--Bone

Fat embolism following major trauma may be associated with a clinical syndrome with widespread pulmonary and systemic manifestations, the most serious being profound hypoxia with secondary atelectasis, pulmonary edema and pulmonary hypertension, and cerebral depression. Though the origin of the embolic fat is debated, there is evidence to support its origin from both the bone marrow and intravascular chylomicron coalescence.The clinical manifestations are largely explained by a prime assault upon the lung parenchyma and alteration in platelet characteristics.Early recognition and treatment of the condition is essential, adequate oxygenation being of prime importance. Steroids and heparin have been found to be of benefit.

Topics: Bone Marrow; Bronchodilator Agents; Chylomicrons; Digitalis; Diuretics; Embolism, Fat; Fracture Fixation; Fractures, Bone; Glucocorticoids; Heparin; Intubation, Intratracheal; Lipid Metabolism; Oxygen Inhalation Therapy; Phytotherapy; Plants, Medicinal; Plants, Toxic; Platelet Adhesiveness; Shock, Hemorrhagic; Wounds and Injuries

Topics: Digitoxin; Fractures, Bone; Hemorrhoids; Humans; Ointments; Surgical Procedures, Operative; Wound Healing; Wounds and Injuries