digitoxin and Cardiomyopathy--Hypertrophic

Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Digitalis; Diuretics; Hemodynamics; Humans; Male; Middle Aged; Plants, Medicinal; Plants, Toxic; Warfarin

Using one- and two-dimensional echocardiographic parameters, left ventricular function and dimensions were investigated in 11 patients with chronic heart failure (NYHA stages II-III) and in 10 normal subjects after administration of low-dose digitoxin (0.07 mg). Tests were performed before the begin of therapy, on the 3rd day following rapid saturation, and on the 15th day under maintenance therapy. There was no significant decrease either of heart volume as assessed by X-ray or of enddiastolic volume measured echocardiographically. However--predominantly in patients--a marked decrease in endsystolic diameter (p less than 0.01) and an increase in posterior wall motion amplitude (p less than 0.05) was observed resulting in increased stroke volume, shortening fraction (p less than 0.001). Early diastolic left ventricular filling speed also increased significantly in both groups (p less than 0.01). Changes in these parameters were more pronounced in patients than in normal subjects. In both groups the effects were achieved soon after rapid saturation, increasing slightly during the period of chronic administration of low-dose digitoxin. Parallel to the changes in echocardiographic parameters, a noticeable clinical improvement occurred among patients. No side effects were observed as serum digitoxin levels were in the therapeutic range. It may be concluded that low-dose digitoxin can be employed to increase cardiac contractility in patients with heart failure.

Topics: Adult; Cardiac Output; Cardiac Volume; Cardiomyopathy, Hypertrophic; Coronary Disease; Digitoxin; Dose-Response Relationship, Drug; Echocardiography; Heart Failure; Heart Rate; Humans; Male; Middle Aged; Myocardial Contraction

Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiomyopathy, Hypertrophic; Digitalis; Double-Blind Method; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Plants, Medicinal; Plants, Toxic; Posture; Practolol; Propranolol; Strophanthins

Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiomyopathy, Hypertrophic; Digitalis; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Pindolol; Plants, Medicinal; Plants, Toxic; Strophanthins

Topics: Alcohol Drinking; Anticoagulants; Cardiomyopathies; Cardiomyopathy, Hypertrophic; Diet, Sodium-Restricted; Digitalis; Digoxin; Diuretics; Ethanol; Female; Heart; Heart Failure; Humans; Male; Phytotherapy; Plants, Medicinal; Plants, Toxic; Practolol; Pregnancy; Propranolol; Rest

Topics: Adolescent; Adult; Angiocardiography; Aortic Valve; Cardiac Catheterization; Cardiomyopathy, Hypertrophic; Diagnosis, Differential; Digitoxin; Humans; Middle Aged; Phonocardiography; Propranolol

Topics: Aortic Valve Stenosis; Cardiomyopathy, Hypertrophic; Constriction, Pathologic; Digitalis; Heart Ventricles; Humans; Ouabain; Strophanthins