digitoxin and Carcinoma--Pancreatic-Ductal

digitoxin has been researched along with Carcinoma--Pancreatic-Ductal* in 1 studies

Other Studies

1 other study(ies) available for digitoxin and Carcinoma--Pancreatic-Ductal

ArticleYear
Personalized chemotherapy profiling using cancer cell lines from selectable mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Mar-01, Volume: 19, Issue:5

    High-throughput chemosensitivity testing of low-passage cancer cell lines can be used to prioritize agents for personalized chemotherapy. However, generating cell lines from primary cancers is difficult because contaminating stromal cells overgrow the malignant cells.. We produced a series of hypoxanthine phosphoribosyl transferase (hprt)-null immunodeficient mice. During growth of human cancers in these mice, hprt-null murine stromal cells replace their human counterparts.. Pancreatic and ovarian cancers explanted from these mice were grown in selection media to produce pure human cancer cell lines. We screened one cell line with a 3,131-drug panel and identified 77 U.S. Food and Drug Administration (FDA)-approved drugs with activity, and two novel drugs to which the cell line was uniquely sensitive. Xenografts of this carcinoma were selectively responsive to both drugs.. Chemotherapy can be personalized using patient-specific cell lines derived in biochemically selectable mice.

    Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Pancreatic Ductal; Cardiotonic Agents; Digitoxin; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Interleukin Receptor Common gamma Subunit; Male; Mice; Mice, Nude; Mice, SCID; Nogalamycin; Ovarian Neoplasms; Pancreatic Neoplasms; Precision Medicine; Stromal Cells; Tumor Cells, Cultured

2013