digitoxin has been researched along with Acromegaly* in 2 studies
2 other study(ies) available for digitoxin and Acromegaly
Article | Year |
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Recent advances on endogenous Na+,K+-ATPase inhibitors: clinical investigation and purification.
Evidence exists which demonstrates the relationship between a Natriuretic Factor or Na+,K+-ATPase inhibitor and volemic expansion, both in man and animal. Patients having extracellular volume expansion have been studied for the effect of their plasma on erythrocytes 3H-ouabain binding. High levels of ouabain-like activity was found in plasma from acromegalic patients and patients with chronic renal failure. High levels were also observed in some hypertensive patients. A partial purification of such a compound was performed from urine of hypertensives. The partially purified compound inhibited to a greater extent the Na+,K+-ATPase semi-purified from dog kidney than that from sheep brain. The present data are consistent with the possible regulation of the activity or the secretion of plasma ouabain-like activity by extracellular volume. Topics: Acromegaly; Animals; ATPase Inhibitory Protein; Binding Sites; Brain; Digitalis; Dogs; Dose-Response Relationship, Drug; Erythrocytes; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Kinetics; Ouabain; Plants, Medicinal; Plants, Toxic; Proteins; Swine | 1985 |
Investigation of the endogenous Na+-pump inhibitor in essential hypertension and blood volume expansion.
The digitalis-like activities of plasma extracts from 108 patients and normal subjects were measured by their ability to compete with ouabain for binding to the digitalis sites of the Na+-pump. High levels were found in 18 of 54 untreated patients with moderate hypertension, 10 of 14 patients with end-stage renal failure and six patients with active acromegaly. These levels returned to control values after dialysis in the patients with renal insufficiency and high levels of the inhibitor, and after successful surgery and cobalt therapy in seven acromegalic patients. An increase in circulating Na+, K+-ATPase inhibitor was also found in rats after chronic sodium loading. These results indicate that levels of the circulating compound with digitalis-like properties do not result from high blood pressure but, rather, are related to blood volume and Na+ balance. Topics: Acromegaly; Adult; Animals; ATPase Inhibitory Protein; Blood Proteins; Blood Volume; Digitalis; Erythrocytes; Female; Humans; Hypertension; Ion Channels; Kidney Failure, Chronic; Male; Middle Aged; Ouabain; Plants, Medicinal; Plants, Toxic; Proteins; Rats; Receptors, Drug; Sodium; Sodium-Potassium-Exchanging ATPase | 1984 |