digitonin has been researched along with Arrhythmias--Cardiac* in 1 studies
1 other study(ies) available for digitonin and Arrhythmias--Cardiac
| Article | Year |
|---|---|
Prevention and reversal of ouabain-induced cardiotoxicity by naloxone in the guinea-pig.
The effects of pre- and post-treatment with naloxone on the cardiotoxicity of ouabain in the guinea-pig were studied. After pretreatment with naloxone, the dose of ouabain required to induce ventricular arrhythmias and cardiac arrest were significantly increased, in a dose-dependent manner, compared with the control, indicating a protective effect of naloxone against digitalis intoxication. Administration of naloxone at the onset of cardiac arrhythmias induced by a lethal dose of ouabain restored the cardiac rhythm and consequently saved life in seven out of eight animals, indicating an antiarrhythmic effect of naloxone in digitalis-intoxicated guinea-pigs. The protective and antiarrhythmic effects of naloxone against digitalis intoxication have clinical implications. Topics: Animals; Arrhythmias, Cardiac; Digitonin; Dose-Response Relationship, Drug; Drug Interactions; Female; Guinea Pigs; Heart; Heart Arrest; Naloxone; Ouabain | 1986 |