difluprednate and Granuloma

To present a case of unilateral hypopyon uveitis that began 15 days after uneventful bilateral LASIK in a 24-year-old man with an undisclosed history of ulcerative colitis.. Case report.. The hypopyon uveitis completely resolved after treatment with aggressive topical and oral steroid agents in combination with topical antibiotic coverage.. Although rare, visually significant hypopyon uveitis may arise after LASIK in the setting of ulcerative colitis and positive human leukocyte antigen (HLA) B27. Early recognition and treatment can result in an excellent outcome. The exact relationship between hypopyon uveitis and LASIK is impossible to ascertain.

Topics: Administration, Oral; Administration, Topical; Astigmatism; Colitis, Ulcerative; Fluprednisolone; Glucocorticoids; Granuloma; Humans; Keratomileusis, Laser In Situ; Lasers, Excimer; Male; Myopia; Postoperative Complications; Prednisone; Tomography, Optical Coherence; Uveitis, Anterior; Young Adult

A pattern-recognition technique has been used to determine structure-activity relationships for antiinflammatory steroids. Experimental results using the human vasoconstrictor test of McKenzie and Stoughton and the rat granuloma cotton pellet method of Meier were correlated with the various substructural descriptors. Steroids were classified into two categories according to potency, and a pattern-recognition method was applied to determine their relative ranking. The resulting structure-activity relationships obtained and the relative contributions of the various structural variables for both bioassays are discussed. A synergistic effect was predicted to be in operation between certain pairs of substituents.

Topics: Animals; Anti-Inflammatory Agents; Drug Synergism; Granuloma; Humans; Models, Chemical; Rats; Steroids; Structure-Activity Relationship; Vasoconstriction