diflunisal has been researched along with Stomach Ulcer in 6 studies
Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A combination of indomethacin and diflunisal, a new salicylic acid derivative, when given to rats, gave a greater reduction in the size of permanganate induced granulomas and less gastric irritation, than either drug given alone." | 3.66 | Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal. ( Conti, P; Continenza, A, 1980) |
| " In-vivo studies indicated that diflunisal-loaded PHEA microparticles significantly improved the gastric tolerance and oral bioavailability of the drug in comparison with free diflunisal." | 1.30 | A hydrogel based on a polyaspartamide: characterization and evaluation of in-vivo biocompatibility and drug release in the rat. ( Cacciaguerra, S; Giammona, G; Govoni, P; Pitarresi, G; Tomarchio, V, 1997) |
| "indomethacin) have been explored as a means for reducing the gastric ulcerogenicity of the latter." | 1.27 | Structural damage and changes in eicosanoid metabolites in the gastric mucosa of rats and pigs induced by anti-inflammatory drugs of varying ulcerogenicity. ( Rainsford, KD, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Humes, JL | 1 |
| Winter, CA | 1 |
| Sadowski, SJ | 1 |
| Kuehl, FA | 1 |
| Conti, P | 2 |
| Continenza, A | 1 |
| Continenza, MA | 1 |
| Cifone, MG | 1 |
| Bruno, G | 1 |
| Alesse, E | 1 |
| Giammona, G | 1 |
| Pitarresi, G | 1 |
| Tomarchio, V | 1 |
| Cacciaguerra, S | 1 |
| Govoni, P | 1 |
| Hung, DY | 1 |
| Mellick, GD | 1 |
| Masci, PP | 1 |
| Whitaker, AN | 1 |
| Whitehouse, MW | 1 |
| Roberts, MS | 1 |
| Rainsford, KD | 1 |
6 other studies available for diflunisal and Stomach Ulcer
| Article | Year |
|---|---|
Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Diflunisal; Indomethaci | 1981 |
Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal.
Topics: Animals; Diflunisal; Drug Therapy, Combination; Granuloma; Indomethacin; Male; Rats; Salicylates; St | 1980 |
[Reduced ulcerogenic effect after treatment with indomethacin combined with diflunisal in rats].
Topics: Animals; Diflunisal; Drug Interactions; Gastric Mucosa; Indomethacin; Male; Potassium Permanganate; | 1980 |
A hydrogel based on a polyaspartamide: characterization and evaluation of in-vivo biocompatibility and drug release in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Dif | 1997 |
Focused antithrombotic therapy: novel anti-platelet salicylates with reduced ulcerogenic potential and higher first-pass detoxification than aspirin in rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Blood Platelets; Diflunisal; Do | 1998 |
Structural damage and changes in eicosanoid metabolites in the gastric mucosa of rats and pigs induced by anti-inflammatory drugs of varying ulcerogenicity.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Diflunisal; Gastric Mucosa; Indomethacin; Membrane Poten | 1986 |