Page last updated: 2024-10-26

diflunisal and Polyneuropathies

diflunisal has been researched along with Polyneuropathies in 1 studies

Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.

Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.

Research Excerpts

ExcerptRelevanceReference
" Herein, we report the diflunisal plasma concentrations measured by extraction, reversed phase HPLC separation, and fluorescence detection after long-term 250 mg BID oral dosing in two groups: a placebo-controlled diflunisal clinical trial group and an open-label Japanese polyneuropathy treatment cohort."1.91Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange. ( Berk, JL; Jäger, M; Kelly, JW; Kline, GM; Nelson, LT; Powers, ET; Sekijima, Y; Tsai, FJ, 2023)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Tsai, FJ3
Nelson, LT3
Kline, GM3
Jäger, M3
Berk, JL3
Sekijima, Y3
Powers, ET3
Kelly, JW3

Other Studies

1 other study available for diflunisal and Polyneuropathies

ArticleYear
Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2023, Volume: 30, Issue:2

    Topics: Amyloid Neuropathies, Familial; Anti-Inflammatory Agents, Non-Steroidal; Diflunisal; Excipients; Hum

2023
Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2023, Volume: 30, Issue:2

    Topics: Amyloid Neuropathies, Familial; Anti-Inflammatory Agents, Non-Steroidal; Diflunisal; Excipients; Hum

2023
Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2023, Volume: 30, Issue:2

    Topics: Amyloid Neuropathies, Familial; Anti-Inflammatory Agents, Non-Steroidal; Diflunisal; Excipients; Hum

2023
Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2023, Volume: 30, Issue:2

    Topics: Amyloid Neuropathies, Familial; Anti-Inflammatory Agents, Non-Steroidal; Diflunisal; Excipients; Hum

2023