diflunisal has been researched along with Osteoarthritis in 19 studies
Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite a wide range of study designs, a multiplicity of international trials of diclofenac in osteoarthritis have disclosed similar results." | 9.06 | International experiences with diclofenac in osteoarthritis. ( Altman, R, 1986) |
| "A single blind randomized endoscopic study comparing the effects of diflunisal and naproxen on the gastric and duodenal mucosa of 34 patients with osteoarthritis was performed over a 2-week period." | 9.06 | A single blind randomized endoscopic study comparing the effects of diflunisal and naproxen in patients with osteoarthritis. ( Garber, EK; Guth, PH; Silpa, ML; Stolz, A, 1986) |
| "Thirty-one patients with osteoarthritis of the knee were treated with either diflunisal (n = 17) or naproxen (n = 14) in a 12-week open-label study." | 9.06 | Efficacy of diflunisal versus naproxen in osteoarthritis of the knee: an open study. ( Deal, CL; Moskowitz, RW, 1986) |
| "An open-label comparison of diflunisal, a nonacetylated salicylate nonsteroidal anti-inflammatory drug (NSAID), and piroxicam, an NSAID belonging to the oxicam family, was conducted in patients with osteoarthritis." | 9.06 | Comparison of diflunisal and piroxicam in the management of patients with osteoarthritis. ( Baumgartner, SW; Lain, D; Lewis, T, 1986) |
| "Fifty patients with osteoarthritis were studied in a double-blind, crossover trial of diflunisal (1000 mg daily) and naproxen (750 mg daily)." | 9.06 | A double-blind crossover trial of diflunisal and naproxen in osteoarthritis. ( De Jager, JP; Fleming, A; White, R, 1987) |
| "Diflunisal, a long acting antiinflammatory analgesic was compared in high (1000 mg daily) and low (750 mg daily) doses with placebo in a randomized, double blind study of 6 weeks' duration in patients with osteoarthritis of the knee." | 9.05 | The efficacy of diflunisal in osteoarthritis of the knee. A Canadian Multicenter Study. ( Davis, P; Lee, P; Prat, A, 1985) |
| "A randomized double-blind study in ambulatory patients with osteoarthritis of hip and/or knee was conducted, comparing the efficacy and safety of diflunisal 500 mg daily with ibuprofen 1200 mg daily, and a period of 8 weeks." | 9.04 | A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis. ( Keet, JG, 1979) |
| "Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity." | 6.36 | Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| " Each dose was given for 14 days and diflunisal apparent oral clearance and serum urate was measured on the last day of each dosing regimen." | 5.27 | Diflunisal disposition and hypouricemic response in osteoarthritis. ( Bertouch, J; Brooks, PM; Harrington, BJ; Meffin, PJ; Veenendaal, JR, 1983) |
| "Despite a wide range of study designs, a multiplicity of international trials of diclofenac in osteoarthritis have disclosed similar results." | 5.06 | International experiences with diclofenac in osteoarthritis. ( Altman, R, 1986) |
| "A single blind randomized endoscopic study comparing the effects of diflunisal and naproxen on the gastric and duodenal mucosa of 34 patients with osteoarthritis was performed over a 2-week period." | 5.06 | A single blind randomized endoscopic study comparing the effects of diflunisal and naproxen in patients with osteoarthritis. ( Garber, EK; Guth, PH; Silpa, ML; Stolz, A, 1986) |
| "Thirty-one patients with osteoarthritis of the knee were treated with either diflunisal (n = 17) or naproxen (n = 14) in a 12-week open-label study." | 5.06 | Efficacy of diflunisal versus naproxen in osteoarthritis of the knee: an open study. ( Deal, CL; Moskowitz, RW, 1986) |
| "An open-label comparison of diflunisal, a nonacetylated salicylate nonsteroidal anti-inflammatory drug (NSAID), and piroxicam, an NSAID belonging to the oxicam family, was conducted in patients with osteoarthritis." | 5.06 | Comparison of diflunisal and piroxicam in the management of patients with osteoarthritis. ( Baumgartner, SW; Lain, D; Lewis, T, 1986) |
| "Fifty patients with osteoarthritis were studied in a double-blind, crossover trial of diflunisal (1000 mg daily) and naproxen (750 mg daily)." | 5.06 | A double-blind crossover trial of diflunisal and naproxen in osteoarthritis. ( De Jager, JP; Fleming, A; White, R, 1987) |
| "Diflunisal, a long acting antiinflammatory analgesic was compared in high (1000 mg daily) and low (750 mg daily) doses with placebo in a randomized, double blind study of 6 weeks' duration in patients with osteoarthritis of the knee." | 5.05 | The efficacy of diflunisal in osteoarthritis of the knee. A Canadian Multicenter Study. ( Davis, P; Lee, P; Prat, A, 1985) |
| "A randomized double-blind study in ambulatory patients with osteoarthritis of hip and/or knee was conducted, comparing the efficacy and safety of diflunisal 500 mg daily with ibuprofen 1200 mg daily, and a period of 8 weeks." | 5.04 | A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis. ( Keet, JG, 1979) |
| "Sixty-two patients with osteoarthrosis entered a 10-week double-blind cross-over trial of diflunisal and naproxen." | 2.65 | Naproxen and diflunisal in osteoarthrosis. ( Brooks, PM; Dougan, MA; Hills, LJ; Smith, PJ; Thomas, D, 1982) |
| "Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity." | 2.36 | Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| " Each dose was given for 14 days and diflunisal apparent oral clearance and serum urate was measured on the last day of each dosing regimen." | 1.27 | Diflunisal disposition and hypouricemic response in osteoarthritis. ( Bertouch, J; Brooks, PM; Harrington, BJ; Meffin, PJ; Veenendaal, JR, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Omdal, R | 1 |
| Altman, RD | 1 |
| Seinfeld, H | 1 |
| Braun, HD | 1 |
| Gordin, A | 1 |
| Karppinen, I | 1 |
| Holttinen, K | 1 |
| Procházka, M | 1 |
| Schlumpf, U | 1 |
| Børkje, B | 1 |
| Meffin, PJ | 1 |
| Brooks, PM | 2 |
| Bertouch, J | 1 |
| Veenendaal, JR | 1 |
| Harrington, BJ | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Pakes, GE | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Dougan, MA | 1 |
| Thomas, D | 1 |
| Hills, LJ | 1 |
| Smith, PJ | 1 |
| Gross, D | 1 |
| Frei, M | 1 |
| Rau, R | 1 |
| Boussina, J | 1 |
| Keet, JG | 1 |
| Altman, R | 1 |
| Lee, P | 2 |
| Davis, P | 2 |
| Prat, A | 2 |
| Garber, EK | 1 |
| Guth, PH | 1 |
| Silpa, ML | 1 |
| Stolz, A | 1 |
| Deal, CL | 1 |
| Moskowitz, RW | 1 |
| Lewis, T | 1 |
| Lain, D | 1 |
| Baumgartner, SW | 1 |
| White, R | 1 |
| De Jager, JP | 1 |
| Fleming, A | 1 |
3 reviews available for diflunisal and Osteoarthritis
| Article | Year |
|---|---|
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran | 1984 |
[The introduction of non-steroidal antirheumatics: is there a rational therapy].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbazoles; Chronic Disease; Diclofe | 1982 |
Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis.
Topics: Diflunisal; Drug Interactions; Humans; Kinetics; Osteoarthritis; Pain; Salicylates; Sprains and Stra | 1980 |
15 trials available for diflunisal and Osteoarthritis
| Article | Year |
|---|---|
[Naprosyn (naproxen) versus Donobid (diflunisal) in the treatment of osteoarthrosis of the hip and knee. A long-term study].
Topics: Adult; Aged; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Hip Joint; Humans; K | 1983 |
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran | 1984 |
Comparison of slow-release indomethacin and diflunisal in patients with arthrosis.
Topics: Adult; Aged; Delayed-Action Preparations; Diflunisal; Female; Humans; Indomethacin; Male; Middle Age | 1984 |
[Diflunisal in the treatment of progressive polyarthritis and osteoarthritis].
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Female; Humans; Male; Middle Age | 1982 |
[Diflunisal or naproxen in arthrosis. A double-blind study].
Topics: Adult; Aged; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Hip Joint; Humans; K | 1982 |
Naproxen and diflunisal in osteoarthrosis.
Topics: Aged; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Humans; Male; Naproxen; Ost | 1982 |
[Diflunisal in the treatment of coxarthrosis and gonarthrosis. A comparative double-blind study with acetylsalicylic acid].
Topics: Adult; Aged; Aspirin; Diflunisal; Double-Blind Method; Drug Evaluation; Female; Hip; Humans; Knee; M | 1980 |
A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis.
Topics: Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Hip Joint; Humans; Ibuprofen; Kne | 1979 |
International experiences with diclofenac in osteoarthritis.
Topics: Aspirin; Clinical Trials as Topic; Diclofenac; Diflunisal; Double-Blind Method; Gastrointestinal Dis | 1986 |
The efficacy of diflunisal in osteoarthritis of the knee: an extended study.
Topics: Clinical Trials as Topic; Diflunisal; Female; Humans; Knee; Male; Middle Aged; Osteoarthritis; Salic | 1986 |
A single blind randomized endoscopic study comparing the effects of diflunisal and naproxen in patients with osteoarthritis.
Topics: Adult; Aged; Clinical Trials as Topic; Diflunisal; Digestive System; Drug Tolerance; Endoscopy; Gast | 1986 |
Efficacy of diflunisal versus naproxen in osteoarthritis of the knee: an open study.
Topics: Adult; Aged; Clinical Trials as Topic; Diflunisal; Drug Tolerance; Female; Humans; Knee Joint; Male; | 1986 |
Comparison of diflunisal and piroxicam in the management of patients with osteoarthritis.
Topics: Clinical Trials as Topic; Diflunisal; Drug Tolerance; Hip Joint; Humans; Knee Joint; Osteoarthritis; | 1986 |
A double-blind crossover trial of diflunisal and naproxen in osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Diflunisal; Double-Blind Method; Drug Administration Schedule; Femal | 1987 |
The efficacy of diflunisal in osteoarthritis of the knee. A Canadian Multicenter Study.
Topics: Adult; Aged; Clinical Trials as Topic; Diflunisal; Digestive System; Female; Humans; Knee Joint; Mal | 1985 |
2 other studies available for diflunisal and Osteoarthritis
| Article | Year |
|---|---|
[Gon- and coxarthrosis. Therapy with diflunisal].
Topics: Adult; Aged; Diflunisal; Female; Hip Joint; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis; S | 1983 |
Diflunisal disposition and hypouricemic response in osteoarthritis.
Topics: Aged; Chromatography, High Pressure Liquid; Creatinine; Diflunisal; Dose-Response Relationship, Drug | 1983 |