diflunisal has been researched along with Heart Failure in 5 studies
Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diflunisal is an approved non-steroidal anti-inflammatory drug that stabilizes TTR, with limited data available regarding effects on cardiac structure and function." | 1.56 | Stabilization of Cardiac Function With Diflunisal in Transthyretin (ATTR) Cardiac Amyloidosis. ( Berk, JL; Connors, LH; Fox, J; Gopal, DM; Hellawell, J; Lohrmann, G; Maurer, MS; Mussinelli, R; Pipilas, A; Ruberg, FL; Siddiqi, OK; Vellanki, N, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lohrmann, G | 1 |
| Pipilas, A | 1 |
| Mussinelli, R | 1 |
| Gopal, DM | 1 |
| Berk, JL | 1 |
| Connors, LH | 1 |
| Vellanki, N | 1 |
| Hellawell, J | 1 |
| Siddiqi, OK | 1 |
| Fox, J | 1 |
| Maurer, MS | 3 |
| Ruberg, FL | 1 |
| Rubin, J | 1 |
| Sarswat, N | 1 |
| Adams, D | 1 |
| Cauquil, C | 1 |
| Théaudin, M | 1 |
| Castaño, A | 1 |
| Drachman, BM | 1 |
| Judge, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis[NCT06034405] | 1,663 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for diflunisal and Heart Failure
| Article | Year |
|---|---|
Cardiac Amyloidosis: Overlooked, Underappreciated, and Treatable.
Topics: Amyloid Neuropathies, Familial; Amyloidosis; Arrhythmias, Cardiac; Benzoates; Benzoxazoles; Biopsy; | 2020 |
[Familial amyloid polyneuropathies: therapeutic issues].
Topics: Amyloid Neuropathies, Familial; Antibodies, Monoclonal; Benzoxazoles; Clinical Trials as Topic; Difl | 2012 |
Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs.
Topics: Amyloid Neuropathies, Familial; Benzoxazoles; Biomarkers; Cardiomyopathies; Cyclooxygenase Inhibitor | 2015 |
2 other studies available for diflunisal and Heart Failure
| Article | Year |
|---|---|
Stabilization of Cardiac Function With Diflunisal in Transthyretin (ATTR) Cardiac Amyloidosis.
Topics: Aged; Aged, 80 and over; Amyloid Neuropathies, Familial; Cardiomyopathies; Diflunisal; Female; Heart | 2020 |
An Orphan Disease No More: Additional Treatment Options for Cardiac Amyloidosis.
Topics: Amyloidosis; Cardiomyopathies; Diflunisal; Heart Failure; Humans; Prealbumin; Rare Diseases | 2020 |