diflunisal has been researched along with Arthritis, Rheumatoid in 22 studies
Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and tolerability of diflunisal (500 mg orally, twice daily) and piroxicam (20 mg orally, once daily) were compared in a 12-week open-label study in 44 patients with active rheumatoid arthritis." | 9.06 | Comparison of diflunisal and piroxicam in the management of patients with rheumatoid arthritis. ( Rice, DM, 1987) |
| "Diflunisal, a nonacetylated salicylate preparation with a prolonged duration of action, was compared with ibuprofen for the treatment of rheumatoid arthritis in a multicenter trial comprising 210 patients." | 9.06 | A 12-week, double-blind, multicenter study comparing diflunisal twice daily and ibuprofen four times daily in the treatment of rheumatoid arthritis. ( Bennett, RM, 1986) |
| "A multicenter, open-label clinical trial evaluated the efficacy and tolerability of diflunisal given twice daily and aspirin given four times daily in the long-term treatment of patients with rheumatoid arthritis." | 9.06 | Comparison of diflunisal and aspirin in long-term treatment of patients with rheumatoid arthritis. ( Shackleford, RW; Turner, RA; Whipple, JP, 1986) |
| "A randomized, double-blind trial was carried out in 47 hospital out-patients, with classical rheumatoid arthritis, to compare the efficacy and tolerance of diflunisal with that of naproxen." | 9.05 | A double-blind, comparative study of diflunisal and naproxen in the treatment of rheumatoid arthritis. ( Devereaux, MD; Douglas, WA, 1983) |
| "Both diflunisal (750 mg/day) and ibuprofen (1600 mg/day) were shown to be superior to placebo in the treatment of rheumatoid arthritis in a double-blind cross-over trial." | 9.05 | Ibuprofen and diflunisal in rheumatoid arthritis: a double-blind comparative trial. ( Ferry, DG; Gibbins, BL; Grennan, DM; Hall, SM; Lum, J; Myers, DB; Palmer, DG, 1981) |
| "In an eight-week double-blind study comparing the new long-acting aspirin derivative, diflunisal, in doses up to 1 g/day with aspirin in doses up to 4 g/day in 16 patients with classical or definite rheumatoid arthritis, diflunisal was more effective in reducing the total articular index (Ritchie) and erythrocyte sedimentation rate and in increasing grip strength." | 9.05 | Diflunisal in rheumatoid arthritis. ( Fishel, B; Weiss, S; Yaron, M, 1981) |
| " In a 12-week double-blind controlled trial diflunisal was compared with naproxen (Naprosyn; Syntex) in patients with rheumatoid arthritis." | 9.05 | Diflunisal in rheumatoid arthritis. A controlled trial. ( Schorn, D, 1981) |
| "A double-blind comparison of the clinical efficacy and tolerance of varying doses of diflunisal (DFS) and acetylsalicylic acid (ASA) was carried out in 15 patients with rheumatoid arthritis who were given no other antirheumatic medication." | 9.05 | Comparison of diflunisal and acetylsalicylic acid in patients with rheumatoid arthritis. ( Ekdahl, C; Håkansson, E; Lindholm, L; Melander, A; Olsson, S; Svensson, B; Wählin-Boll, E, 1981) |
| "Diflunisal, a new difluorophenyl derivative of salicylic acid was compared with acetylsalicylic acid in 16 patients with rheumatoid arthritis in a double-blind study during 8 weeks." | 9.05 | [Comparison of the efficacy of diflunisal and acetylsalicylic acid in rheumatoid arthritis (author's transl)]. ( Fasching, U, 1981) |
| "A 4-week, double-blind, controlled multi-centre study was carried out in 235 patients with active rheumatoid arthritis to compare the efficacy and tolerance of 500 mg or 1000 mg diflunisal per day administered once daily, in the evening, or in divided, twice daily dosage." | 9.05 | Diflunisal ('Dolobid') once-a-day in the treatment of rheumatoid arthritis. ( Bocanegra, TS; Bolognese, JA; Carpignano, M; Dicenta, C; Neu, DC, 1985) |
| "The single-dose plasma kinetics of diflunisal was studied in healthy young and old subjects, in patients with rheumatoid arthritis, and in patients with renal failure." | 7.67 | Influence of renal failure, rheumatoid arthritis and old age on the pharmacokinetics of diflunisal. ( Erikson, LO; Lindholm, L; Melander, A; Odar-Cederlöf, I; Wåhlin-Boll, E, 1989) |
| "Ninety patients with active rheumatoid arthritis took part in a cross-over trial comparing diclofenac sodium, diflunisal and naproxen." | 7.66 | Diclofenac sodium, diflunisal and naproxen: patient preferences for anti-inflammatory drugs in rheumatoid arthritis. ( Dieppe, PA; Huskisson, EC; Jones, H; Scott, J, 1982) |
| "The efficacy and tolerability of diflunisal (500 mg orally, twice daily) and piroxicam (20 mg orally, once daily) were compared in a 12-week open-label study in 44 patients with active rheumatoid arthritis." | 5.06 | Comparison of diflunisal and piroxicam in the management of patients with rheumatoid arthritis. ( Rice, DM, 1987) |
| "Diflunisal, a nonacetylated salicylate preparation with a prolonged duration of action, was compared with ibuprofen for the treatment of rheumatoid arthritis in a multicenter trial comprising 210 patients." | 5.06 | A 12-week, double-blind, multicenter study comparing diflunisal twice daily and ibuprofen four times daily in the treatment of rheumatoid arthritis. ( Bennett, RM, 1986) |
| "A multicenter, open-label clinical trial evaluated the efficacy and tolerability of diflunisal given twice daily and aspirin given four times daily in the long-term treatment of patients with rheumatoid arthritis." | 5.06 | Comparison of diflunisal and aspirin in long-term treatment of patients with rheumatoid arthritis. ( Shackleford, RW; Turner, RA; Whipple, JP, 1986) |
| "Diflunisal, a new nonsteroidal, Aspirin-like anti-inflammatory agent has been compared with Ibuprofen und Placebo in a six-week double-blind randomized crossover controlled study in 24 patients with rheumatoid arthritis." | 5.05 | [Comparison of the effects of diflunisal, ibuprofen and placebo in chronic polyarthritis]. ( Fasching, U, 1983) |
| "A randomized, double-blind trial was carried out in 47 hospital out-patients, with classical rheumatoid arthritis, to compare the efficacy and tolerance of diflunisal with that of naproxen." | 5.05 | A double-blind, comparative study of diflunisal and naproxen in the treatment of rheumatoid arthritis. ( Devereaux, MD; Douglas, WA, 1983) |
| "Both diflunisal (750 mg/day) and ibuprofen (1600 mg/day) were shown to be superior to placebo in the treatment of rheumatoid arthritis in a double-blind cross-over trial." | 5.05 | Ibuprofen and diflunisal in rheumatoid arthritis: a double-blind comparative trial. ( Ferry, DG; Gibbins, BL; Grennan, DM; Hall, SM; Lum, J; Myers, DB; Palmer, DG, 1981) |
| "In an eight-week double-blind study comparing the new long-acting aspirin derivative, diflunisal, in doses up to 1 g/day with aspirin in doses up to 4 g/day in 16 patients with classical or definite rheumatoid arthritis, diflunisal was more effective in reducing the total articular index (Ritchie) and erythrocyte sedimentation rate and in increasing grip strength." | 5.05 | Diflunisal in rheumatoid arthritis. ( Fishel, B; Weiss, S; Yaron, M, 1981) |
| " In a 12-week double-blind controlled trial diflunisal was compared with naproxen (Naprosyn; Syntex) in patients with rheumatoid arthritis." | 5.05 | Diflunisal in rheumatoid arthritis. A controlled trial. ( Schorn, D, 1981) |
| "A double-blind comparison of the clinical efficacy and tolerance of varying doses of diflunisal (DFS) and acetylsalicylic acid (ASA) was carried out in 15 patients with rheumatoid arthritis who were given no other antirheumatic medication." | 5.05 | Comparison of diflunisal and acetylsalicylic acid in patients with rheumatoid arthritis. ( Ekdahl, C; Håkansson, E; Lindholm, L; Melander, A; Olsson, S; Svensson, B; Wählin-Boll, E, 1981) |
| "Diflunisal, a new difluorophenyl derivative of salicylic acid was compared with acetylsalicylic acid in 16 patients with rheumatoid arthritis in a double-blind study during 8 weeks." | 5.05 | [Comparison of the efficacy of diflunisal and acetylsalicylic acid in rheumatoid arthritis (author's transl)]. ( Fasching, U, 1981) |
| "A 4-week, double-blind, controlled multi-centre study was carried out in 235 patients with active rheumatoid arthritis to compare the efficacy and tolerance of 500 mg or 1000 mg diflunisal per day administered once daily, in the evening, or in divided, twice daily dosage." | 5.05 | Diflunisal ('Dolobid') once-a-day in the treatment of rheumatoid arthritis. ( Bocanegra, TS; Bolognese, JA; Carpignano, M; Dicenta, C; Neu, DC, 1985) |
| " We describe 2 patients who unexpectedly had toxic range serum salicylate levels while taking diflunisal and aspirin for rheumatoid arthritis." | 3.68 | Inability to interpret toxic salicylate levels in patients taking aspirin and diflunisal. ( Adelman, HM; Flannery, MT; Wallach, PM, 1991) |
| "The single-dose plasma kinetics of diflunisal was studied in healthy young and old subjects, in patients with rheumatoid arthritis, and in patients with renal failure." | 3.67 | Influence of renal failure, rheumatoid arthritis and old age on the pharmacokinetics of diflunisal. ( Erikson, LO; Lindholm, L; Melander, A; Odar-Cederlöf, I; Wåhlin-Boll, E, 1989) |
| "Ninety patients with active rheumatoid arthritis took part in a cross-over trial comparing diclofenac sodium, diflunisal and naproxen." | 3.66 | Diclofenac sodium, diflunisal and naproxen: patient preferences for anti-inflammatory drugs in rheumatoid arthritis. ( Dieppe, PA; Huskisson, EC; Jones, H; Scott, J, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (95.45) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shichikawa, K | 1 |
| Warabi, H | 1 |
| Ogawa, N | 1 |
| Fasching, U | 2 |
| Devereaux, MD | 1 |
| Douglas, WA | 1 |
| Procházka, M | 1 |
| Schlumpf, U | 1 |
| Car, A | 1 |
| Berdnik-Gortan, K | 1 |
| Henneberg, Z | 1 |
| Pucar, I | 1 |
| Wessel, G | 1 |
| Reinicke, C | 1 |
| de Silva, M | 1 |
| Hazleman, BL | 1 |
| Dippy, JE | 1 |
| Trnavský, K | 1 |
| Zbojanová, M | 1 |
| Bosmanský, K | 1 |
| Palmer, DG | 1 |
| Ferry, DG | 1 |
| Gibbins, BL | 1 |
| Hall, SM | 1 |
| Grennan, DM | 1 |
| Lum, J | 1 |
| Myers, DB | 1 |
| Fishel, B | 1 |
| Weiss, S | 1 |
| Yaron, M | 1 |
| Schorn, D | 1 |
| Lindholm, L | 2 |
| Ekdahl, C | 1 |
| Håkansson, E | 1 |
| Melander, A | 2 |
| Olsson, S | 1 |
| Svensson, B | 1 |
| Wählin-Boll, E | 2 |
| Huskisson, EC | 1 |
| Dieppe, PA | 1 |
| Scott, J | 1 |
| Jones, H | 1 |
| Adelman, HM | 1 |
| Wallach, PM | 1 |
| Flannery, MT | 1 |
| Erikson, LO | 1 |
| Odar-Cederlöf, I | 1 |
| Bocanegra, TS | 1 |
| Dicenta, C | 1 |
| Carpignano, M | 1 |
| Neu, DC | 1 |
| Bolognese, JA | 1 |
| Rice, DM | 1 |
| Bobrove, AM | 1 |
| Bennett, RM | 1 |
| Turner, RA | 1 |
| Shackleford, RW | 1 |
| Whipple, JP | 1 |
1 review available for diflunisal and Arthritis, Rheumatoid
| Article | Year |
|---|---|
[The introduction of non-steroidal antirheumatics: is there a rational therapy].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbazoles; Chronic Disease; Diclofe | 1982 |
16 trials available for diflunisal and Arthritis, Rheumatoid
| Article | Year |
|---|---|
[Clinical evaluation of diflunisal in rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Femal | 1983 |
[Comparison of the effects of diflunisal, ibuprofen and placebo in chronic polyarthritis].
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Humans; Ibup | 1983 |
A double-blind, comparative study of diflunisal and naproxen in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1983 |
[Diflunisal in the treatment of progressive polyarthritis and osteoarthritis].
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Female; Humans; Male; Middle Age | 1982 |
[Diflunisal in the treatment of rheumatoid arthritis].
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Hum | 1982 |
Diflunisal and aspirin: a comparative study in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diflunisal; Double-Blind Meth | 1980 |
[Diflunisal in rheumatoid arthritis. A double-blind therapeutical study report (author's transl)].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Humans; Ma | 1981 |
Ibuprofen and diflunisal in rheumatoid arthritis: a double-blind comparative trial.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Humans; Ib | 1981 |
Diflunisal in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Aspirin; Blood Sedimentation; Clinical Trials as Topic; Diflunisal; Dou | 1981 |
Diflunisal in rheumatoid arthritis. A controlled trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Femal | 1981 |
Comparison of diflunisal and acetylsalicylic acid in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diflunisal; Dose-Response Rel | 1981 |
[Comparison of the efficacy of diflunisal and acetylsalicylic acid in rheumatoid arthritis (author's transl)].
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Diflunisal; Dose-Response Relationship, Drug; Double-Bl | 1981 |
Diflunisal ('Dolobid') once-a-day in the treatment of rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind M | 1985 |
Comparison of diflunisal and piroxicam in the management of patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Female; Humans; Male; Midd | 1987 |
A 12-week, double-blind, multicenter study comparing diflunisal twice daily and ibuprofen four times daily in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Drug | 1986 |
Comparison of diflunisal and aspirin in long-term treatment of patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diflunisal; Double-Blind Meth | 1986 |
5 other studies available for diflunisal and Arthritis, Rheumatoid
| Article | Year |
|---|---|
[Ground rules in pharmacotherapy of rheumatic diseases].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cortisone; | 1980 |
Diclofenac sodium, diflunisal and naproxen: patient preferences for anti-inflammatory drugs in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Consumer Behavior; Diclofenac; Diflunisal; Female; Humans; Male; | 1982 |
Inability to interpret toxic salicylate levels in patients taking aspirin and diflunisal.
Topics: Arthritis, Rheumatoid; Aspirin; Diflunisal; Female; Humans; Male; Middle Aged; Salicylates | 1991 |
Influence of renal failure, rheumatoid arthritis and old age on the pharmacokinetics of diflunisal.
Topics: Adolescent; Adult; Aged; Aging; Arthritis, Rheumatoid; Diflunisal; Female; Half-Life; Humans; Kidney | 1989 |
Diflunisal-associated thrombocytopenia in a patient with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Diflunisal; Humans; Male; Salicylates; Thrombocytopenia | 1988 |