diflunisal has been researched along with Amyloidosis in 11 studies
Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diflunisal was well-tolerated in both the ATTRm- and ATTRwt-CA populations." | 5.48 | Diflunisal tolerability in transthyretin cardiac amyloidosis: a single center's experience. ( Donnelly, JP; Hanna, M; Ikram, A; Samaras, C; Sperry, BW; Valent, J, 2018) |
| "Diflunisal was well-tolerated in both the ATTRm- and ATTRwt-CA populations." | 1.48 | Diflunisal tolerability in transthyretin cardiac amyloidosis: a single center's experience. ( Donnelly, JP; Hanna, M; Ikram, A; Samaras, C; Sperry, BW; Valent, J, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Yokoyama, T | 2 |
| Kosaka, Y | 1 |
| Mizuguchi, M | 2 |
| Iakovleva, I | 2 |
| Brännström, K | 2 |
| Nilsson, L | 2 |
| Gharibyan, AL | 1 |
| Begum, A | 2 |
| Anan, I | 1 |
| Walfridsson, M | 1 |
| Sauer-Eriksson, AE | 2 |
| Olofsson, A | 2 |
| Rubin, J | 1 |
| Maurer, MS | 1 |
| Sarswat, N | 1 |
| Ikram, A | 1 |
| Donnelly, JP | 1 |
| Sperry, BW | 1 |
| Samaras, C | 1 |
| Valent, J | 1 |
| Hanna, M | 1 |
| Wijsekera, A | 1 |
| Zhang, J | 1 |
| Andersson, PL | 1 |
| Sawada, N | 1 |
| Nakayama, A | 1 |
| Takahashi, M | 1 |
| Tanaka, M | 1 |
| Morita, H | 1 |
| Akazawa, H | 1 |
| Komuro, I | 1 |
| Green, NS | 1 |
| Palaninathan, SK | 1 |
| Sacchettini, JC | 1 |
| Kelly, JW | 2 |
| Reixach, N | 1 |
| Adamski-Werner, SL | 1 |
| Koziol, J | 1 |
| Buxbaum, JN | 1 |
| Gillmore, JD | 1 |
| Hawkins, PN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis[NCT06034405] | 1,663 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for diflunisal and Amyloidosis
| Article | Year |
|---|---|
Cardiac Amyloidosis: Overlooked, Underappreciated, and Treatable.
Topics: Amyloid Neuropathies, Familial; Amyloidosis; Arrhythmias, Cardiac; Benzoates; Benzoxazoles; Biopsy; | 2020 |
Inhibition of the Amyloidogenesis of Transthyretin by Natural Products and Synthetic Compounds.
Topics: Amyloid; Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Biological Products; Di | 2018 |
Drug Insight: emerging therapies for amyloidosis.
Topics: Alzheimer Disease; Amyloidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Acids; | 2006 |
8 other studies available for diflunisal and Amyloidosis
| Article | Year |
|---|---|
Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin.
Topics: Amyloid Neuropathies, Familial; Amyloidosis; Caffeic Acids; Coumaric Acids; Masoprocol; Phenylethyl | 2014 |
Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma.
Topics: Amyloidosis; Calorimetry; Drug Design; Humans; Ligands; Models, Molecular; Plasma; Prealbumin; Prote | 2015 |
An Orphan Disease No More: Additional Treatment Options for Cardiac Amyloidosis.
Topics: Amyloidosis; Cardiomyopathies; Diflunisal; Heart Failure; Humans; Prealbumin; Rare Diseases | 2020 |
Diflunisal tolerability in transthyretin cardiac amyloidosis: a single center's experience.
Topics: Aged; Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal; Cardiomyopathies; Diflunisal; Female; Hu | 2018 |
Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer.
Topics: Amyloid; Amyloidosis; Benzoxazoles; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Difluni | 2016 |
Correct Diagnosis of Wild-Type Transthyretin-Related Amyloidosis Followed by the Introduction of a Novel Therapy in a Patient With Cardiac Wall Thickening of Unknown Cause.
Topics: Aged; Amyloid; Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal; Diflunisal; Electrocardiography | 2017 |
Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.
Topics: Amyloid; Amyloidosis; Biphenyl Compounds; Crystallography, X-Ray; Dicarboxylic Acids; Diflunisal; Dr | 2003 |
Cell based screening of inhibitors of transthyretin aggregation.
Topics: Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Lineage; Cell Survival; | 2006 |