diflunisal has been researched along with Alzheimer Disease in 11 studies
Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 5 (45.45) | 2.80 |
| Authors | Studies |
|---|---|
| Ciccone, L | 1 |
| Nencetti, S | 1 |
| Tonali, N | 1 |
| Fruchart-Gaillard, C | 1 |
| Shepard, W | 1 |
| Nuti, E | 1 |
| Camodeca, C | 1 |
| Rossello, A | 1 |
| Orlandini, E | 1 |
| Mateev, E | 1 |
| Kondeva-Burdina, M | 1 |
| Georgieva, M | 1 |
| Zlatkov, A | 1 |
| Rejc, L | 1 |
| Gómez-Vallejo, V | 1 |
| Rios, X | 1 |
| Cossío, U | 1 |
| Baz, Z | 1 |
| Mujica, E | 1 |
| Gião, T | 1 |
| Cotrina, EY | 2 |
| Jiménez-Barbero, J | 2 |
| Quintana, J | 2 |
| Arsequell, G | 3 |
| Cardoso, I | 5 |
| Llop, J | 2 |
| Shin, MK | 1 |
| Vázquez-Rosa, E | 1 |
| Koh, Y | 1 |
| Dhar, M | 1 |
| Chaubey, K | 1 |
| Cintrón-Pérez, CJ | 1 |
| Barker, S | 1 |
| Miller, E | 1 |
| Franke, K | 1 |
| Noterman, MF | 1 |
| Seth, D | 1 |
| Allen, RS | 1 |
| Motz, CT | 1 |
| Rao, SR | 1 |
| Skelton, LA | 1 |
| Pardue, MT | 1 |
| Fliesler, SJ | 1 |
| Wang, C | 1 |
| Tracy, TE | 1 |
| Gan, L | 1 |
| Liebl, DJ | 1 |
| Savarraj, JPJ | 1 |
| Torres, GL | 1 |
| Ahnstedt, H | 1 |
| McCullough, LD | 1 |
| Kitagawa, RS | 1 |
| Choi, HA | 1 |
| Zhang, P | 1 |
| Hou, Y | 1 |
| Chiang, CW | 1 |
| Li, L | 1 |
| Ortiz, F | 1 |
| Kilgore, JA | 1 |
| Williams, NS | 1 |
| Whitehair, VC | 1 |
| Gefen, T | 1 |
| Flanagan, ME | 1 |
| Stamler, JS | 1 |
| Jain, MK | 1 |
| Kraus, A | 1 |
| Cheng, F | 1 |
| Reynolds, JD | 1 |
| Pieper, AA | 1 |
| Koike, H | 1 |
| Katsuno, M | 1 |
| Alemi, M | 2 |
| Silva, SC | 1 |
| Santana, I | 1 |
| Gimeno, A | 1 |
| Santos, LM | 1 |
| Rivas, J | 1 |
| Blasi, D | 1 |
| Valencia, G | 2 |
| Ribeiro, CA | 2 |
| Oliveira, SM | 1 |
| Guido, LF | 1 |
| Magalhães, A | 1 |
| Saraiva, MJ | 2 |
| Maher, A | 1 |
| El-Sayed, NS | 1 |
| Breitinger, HG | 1 |
| Gad, MZ | 1 |
| Gillmore, JD | 1 |
| Hawkins, PN | 1 |
3 reviews available for diflunisal and Alzheimer Disease
| Article | Year |
|---|---|
Repurposing of FDA-approved drugs as dual-acting MAO-B and AChE inhibitors against Alzheimer's disease: An in silico and in vitro study.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Diflunisal; Drug Repositioning; | 2023 |
The Ultrastructure of Tissue Damage by Amyloid Fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid Neuropathies, Familial; Benzoxazoles; Diflunisal; Humans; Immuno | 2021 |
Drug Insight: emerging therapies for amyloidosis.
Topics: Alzheimer Disease; Amyloidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Acids; | 2006 |
8 other studies available for diflunisal and Alzheimer Disease
| Article | Year |
|---|---|
Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis.
Topics: Alzheimer Disease; Binding Sites; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Confo | 2020 |
Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-β Formation in a Transgenic Mouse Model of Alzheimer's Disease: A Longitudinal in vivo Molecular Imaging Study1.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Diflunisal; Female | 2020 |
Reducing acetylated tau is neuroprotective in brain injury.
Topics: Acetylation; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Brain | 2021 |
Transthyretin stability is critical in assisting beta amyloid clearance- Relevance of transthyretin stabilization in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blood-Brain Barri | 2017 |
Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Crystallography, X-Ray; Diflunisal; Humans; Magnetic Reson | 2017 |
Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognition | 2014 |
Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: modulation by NOS inhibitors.
Topics: Alzheimer Disease; Amidines; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2014 |
Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Cell Line, Tumor; Diflunisal; Dinitrophenols; Hum | 2012 |