diflucortolone and Skin-Diseases--Bacterial

Fungal skin infections, or dermatomycoses, are associated with a broad range of pathogens. Involvement of gram-positive bacteria is often suspected in dermatomycoses. Inflammation plays an important role in dermatomycoses, displaying a close association between frequent inflammation and reduced skin-related quality of life. Isoconazole nitrate (ISN) is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, a rapid rate of absorption and low systemic exposure potential. ISN is effective against pathogens involved in dermatomycoses, with minimum inhibitory concentrations well below the concentration of ISN in skin and hair follicles. The combination of the corticosteroid diflucortolone valerate with ISN (Travocort) increases the local bioavailability of ISN. Compared with ISN monotherapy, Travocort has a faster onset of antimycotic action, faster relief of itch and other inflammatory symptoms, improved overall therapeutic benefits and earlier mycological cure rate. Travocort is effective in the treatment of inflammatory mycotic infections, and also in the eradication of accompanied gram-positive bacterial infections. The rapid improvement observed with Travocort treatment, combined with favourable safety and tolerability, results in higher patient satisfaction, and therefore, can be an effective tool to increase treatment adherence in patients with dermatomycoses accompanied by inflammatory signs and symptoms.

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Coinfection; Dermatomycoses; Diflucortolone; Drug Combinations; Gram-Positive Bacterial Infections; Humans; Medication Adherence; Miconazole; Skin Diseases, Bacterial; Treatment Outcome

Paederus dermatitis, a type of irritant contact dermatitis attributed to a Staphylinid beetle, is prevalent in most parts of the world. We studied 50 cases of Paederus dermatitis at the United Nations Hospital at Koidu Sierra Leone (West Africa), over a period of 6 months from Oct 2003 to Mar 2004. The objectives of the study were to determine clinical patterns of dermatitis and its response to topical steroids, with and without antibiotics. Patients with a definite history of contact with the insect were included in the study. Amongst these, 14 of the more severe cases were treated with oral prednisolone or intralesional triamcinolone acetonide. The remainder of the 36 patients were divided in two equal groups A and B. Patients in Group A were treated with topical diflucortolone valerate 0.001 percent and oral cetirizine hydrochloride; patients in group B were given oral ciprofloxacin in addition. In 50 patients studied, 43 (86%) were males and 7 (14%) were females. The neck was the most common site involved followed by face. Healing time ranged from 14 to 28 days and lesions in all the patients healed with residual dyschromia. Healing time was shorter in Group B patients in comparison with those in Group A. Paederus dermatitis in Sierra Leone is a relatively severe form of this dermatitis. The better response to a combination of topical steroids and oral antibiotics may indicate concurrent bacterial infection.

Topics: Administration, Oral; Administration, Topical; Adult; Animals; Anti-Bacterial Agents; Cetirizine; Ciprofloxacin; Coleoptera; Dermatitis, Irritant; Diflucortolone; Female; Glucocorticoids; Humans; Injections, Intralesional; Male; Prednisolone; Sierra Leone; Skin Diseases, Bacterial; Triamcinolone Acetonide

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Coinfection; Dermatomycoses; Diflucortolone; Drug Combinations; Humans; Miconazole; Skin Diseases, Bacterial; Treatment Outcome

Undetected tinea pedis in a patient with diabetes can lead to serious bacterial infections with potentially serious consequences, such as foot amputations. Here we report on a 60-year-old patient with diabetes presenting with pain, severe pruritus, and malodour in the foot's interdigital area, and subsequently, diagnosed with inflammatory tinea pedis with bacterial superinfection. The patient was successfully treated with Travocort cream containing isoconazole nitrate 1% and diflucortolone valerate 0.1%; marked improvement occurred within 5 days.

Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Diabetes Complications; Diflucortolone; Humans; Male; Miconazole; Middle Aged; Skin Diseases, Bacterial; Superinfection; Tinea Pedis; Treatment Outcome

Trichophyton mentagrophytes is the dermatophyte species most commonly reported in cases of guinea pig-associated dermatophytosis (or guinea pig fungus) a condition that more often affects children than adults. In this case, a 13-year-old girl with recent direct contact with guinea pigs presented with a previously undertreated inflammatory skin lesion on the left side of her upper body, which was positive both for Trichophyton mentagrophytes and Staphylococcus epidermidis. The condition was subsequently diagnosed as tinea corporis due to Trichophyton mentagrophytes with concomitant bacterial infection and effectively treated with 2 weeks of twice-daily application of Travocort cream containing isoconazole nitrate 1% and diflucortolone valerate 0.1%. Visible improvement in the lesion was apparent after only 1 week of treatment.

Topics: Administration, Topical; Adolescent; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Diflucortolone; Environmental Exposure; Female; Gram-Positive Bacterial Infections; Guinea Pigs; Humans; Miconazole; Skin Diseases, Bacterial; Staphylococcus epidermidis; Tinea; Treatment Outcome; Trichophyton