diflucortolone and Erythema

Topics: Aged, 80 and over; Anti-Inflammatory Agents; Clobetasol; Diflucortolone; Erythema; Humans; Male; Prednisone; Sweet Syndrome

Many tinea inguinalis infections are characterized by pronounced inflammatory lesions and pruritus. Therefore, a therapy with a topical corticosteroid in addition to a topical antimycotic agent might be beneficial. In this multicenter, retrospective study, we compared the mycological and clinical efficacy and tolerability of isoconazole nitrate alone vs isoconazole nitrate and diflucortolone valerate in 58 adult patients with tinea inguinalis.. Treatment duration was three weeks. The efficacy of the treatment was based on the assessment of several signs and symptoms, which were collected on a 4-point scale. All patients were examined clinically before the beginning of the treatment, one week later, two weeks later, and at the end of the treatment. Mycological examinations were performed before the beginning of the treatment and at the end of the study.. Treatment results with the combination of isoconazole nitrate and diflucortolone valerate were superior regarding erythema and pruritus. Both erythema and pruritus resolved in a larger percentage of patients and more quickly. Both regimens were well tolerated. Mycological cure rates were similar in both groups of patients.. Combination therapy with isoconazole nitrate and diflucortolone valerate is an effective and well-tolerated regimen in adult patients with tinea inguinalis.

Topics: Administration, Cutaneous; Adolescent; Adult; Antifungal Agents; Diflucortolone; Drug Therapy, Combination; Erythema; Humans; Male; Miconazole; Middle Aged; Pruritus; Retrospective Studies; Time Factors; Tinea; Treatment Outcome; Young Adult

Abstract Reticular erythematous mucinosis (REM) is a rare chronic mucinosis. Histologically, the presence of mucin in the upper dermis is the most specific feature. A 73-year-old woman presented to our outpatient clinic with a 4-year history of netlike macular erythema with slight edema on her left arm. She was diagnosed as having REM on the basis of the clinical picture and histological findings. She was treated with ultraviolet B irradiation using the VTRAC Excimer Lamp system with favorable response. This is the first reported case that was treated with a 308-nm excimer lamp.

Topics: Aged; Antimalarials; Cyclosporine; Diflucortolone; Erythema; Female; Humans; Mucinoses; Treatment Outcome; Ultraviolet Therapy