difenacoum and Poisoning

difenacoum has been researched along with Poisoning* in 2 studies

Other Studies

2 other study(ies) available for difenacoum and Poisoning

Article	Year
Importance of segmental hair analysis in a suspected case of attempted homicide by flocoumafen and difenacoum. Forensic science international, 2020, Volume: 316 The 4-hydroxycoumarin derivatives are the most used rodenticides and act as classical anticoagulants, interfering with the production of clotting factors in liver by antagonizing the action of vitamin K reductase, thereby inhibiting recycling of vitamin K1, involved in activation of blood clotting factors, resulting in massive bleeding. In this paper, we present the case of a 72-year old man providing abnormal coagulation parameters (PT-INR between 16.1 and 19.1) after hospitalization. Blood samples tested positive for flocoumafen and difenacoum, two superwarfarin rodenticides. Patient's hair specimens, sampled 19 days after his hospitalization, showed that traces of both difenacoum and flocoumafen were detected in the first 1 cm; in the intermediate segments (1-2 and 2-3 cm), both difenacoum and flocoumafen were absent, while in the distal segment (3-4.5 cm), only difenacoum was found, but in significant amounts (140 pg/mg). Exposure to difenacoum in the past months, at least 4-5 before hospitalization, was confirmed by the presence of the rodenticide in the distal segment. Moreover, among the seized material, two specimens resulted compatible with the two rodenticides. Topics: 4-Hydroxycoumarins; Aged; Chromatography, Liquid; Forensic Toxicology; Hair; Homicide; Hospitalization; Humans; International Normalized Ratio; Male; Mass Spectrometry; Poisoning; Prothrombin Time; Rodenticides	2020
Shortfalls using second-generation anticoagulant rodenticides. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2002, Volume: 33, Issue:1 Second-generation anticoagulant rodenticides can give rise to unexpected casualties in nontarget species in zoos. The first two offspring of a pair of turkey vultures (Cathartes aura) died of brodifacoum toxicosis. The adult birds fed rodenticide-killed mice to their offspring. There are previous case reports of small carnivorous birds (Dacelo novae-guinae and Tockus deckeni) killed eating poisoned (difenacoum and brodifacoum) mice. Even a granivorous species (Rollulus roulroul) died, probably by contamination of its food by cockroaches that transported the rodenticide. Topics: 4-Hydroxycoumarins; Animal Feed; Animals; Animals, Zoo; Anticoagulants; Bird Diseases; Birds; Fatal Outcome; Muridae; Poisoning; Raptors; Rodenticides	2002

Article

Year

Importance of segmental hair analysis in a suspected case of attempted homicide by flocoumafen and difenacoum.

Forensic science international, 2020, Volume: 316

The 4-hydroxycoumarin derivatives are the most used rodenticides and act as classical anticoagulants, interfering with the production of clotting factors in liver by antagonizing the action of vitamin K reductase, thereby inhibiting recycling of vitamin K1, involved in activation of blood clotting factors, resulting in massive bleeding. In this paper, we present the case of a 72-year old man providing abnormal coagulation parameters (PT-INR between 16.1 and 19.1) after hospitalization. Blood samples tested positive for flocoumafen and difenacoum, two superwarfarin rodenticides. Patient's hair specimens, sampled 19 days after his hospitalization, showed that traces of both difenacoum and flocoumafen were detected in the first 1 cm; in the intermediate segments (1-2 and 2-3 cm), both difenacoum and flocoumafen were absent, while in the distal segment (3-4.5 cm), only difenacoum was found, but in significant amounts (140 pg/mg). Exposure to difenacoum in the past months, at least 4-5 before hospitalization, was confirmed by the presence of the rodenticide in the distal segment. Moreover, among the seized material, two specimens resulted compatible with the two rodenticides.

Topics: 4-Hydroxycoumarins; Aged; Chromatography, Liquid; Forensic Toxicology; Hair; Homicide; Hospitalization; Humans; International Normalized Ratio; Male; Mass Spectrometry; Poisoning; Prothrombin Time; Rodenticides

2020

Shortfalls using second-generation anticoagulant rodenticides.

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2002, Volume: 33, Issue:1

Second-generation anticoagulant rodenticides can give rise to unexpected casualties in nontarget species in zoos. The first two offspring of a pair of turkey vultures (Cathartes aura) died of brodifacoum toxicosis. The adult birds fed rodenticide-killed mice to their offspring. There are previous case reports of small carnivorous birds (Dacelo novae-guinae and Tockus deckeni) killed eating poisoned (difenacoum and brodifacoum) mice. Even a granivorous species (Rollulus roulroul) died, probably by contamination of its food by cockroaches that transported the rodenticide.

Topics: 4-Hydroxycoumarins; Animal Feed; Animals; Animals, Zoo; Anticoagulants; Bird Diseases; Birds; Fatal Outcome; Muridae; Poisoning; Raptors; Rodenticides

2002