diethylnitrosamine has been researched along with Obesity in 12 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 8.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC)." | 5.48 | Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis. ( Inoue-Yamauchi, A; Itagaki, H; Oda, H, 2018) |
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 4.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| " Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity." | 3.81 | Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Shimizu, M; Shirakami, Y; Tanaka, T; Tsurumi, H, 2015) |
| "Pitavastatin is effective in inhibiting the early phase of obesity-related liver tumorigenesis and, therefore, may be useful in the chemoprevention of liver cancer in obese individuals." | 3.77 | Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Sakai, H; Shimizu, M; Tanaka, T; Terakura, D; Tsurumi, H; Yasuda, Y, 2011) |
| " The serum levels of glucose and leptin decreased by dietary BCAA, whereas the value of the quantitative insulin sensitivity check index increased by this agent, indicating the improvement of insulin resistance and hyperleptinemia." | 3.76 | Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. ( Iwasa, J; Moriwaki, H; Sakai, H; Shimizu, M; Shirakami, Y; Shiraki, M; Takai, K; Tanaka, T; Terakura, Y; Tsurumi, H, 2010) |
| "Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC)." | 1.48 | Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis. ( Inoue-Yamauchi, A; Itagaki, H; Oda, H, 2018) |
| "Obesity is associated with both endoplasmic reticulum (ER) stress and chronic metabolic inflammation." | 1.48 | Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice. ( Cai, J; Chen, T; Dai, J; Fang, J; Feng, Y; Liu, J; Liu, Y; Lv, S; Rui, L; Shan, B; Wang, Y; Wu, Y; Xia, Z; Xie, D; Zheng, L, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 10 (83.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Raffaele, M | 1 |
| Kovacovicova, K | 1 |
| Frohlich, J | 1 |
| Lo Re, O | 1 |
| Giallongo, S | 1 |
| Oben, JA | 1 |
| Faldyna, M | 1 |
| Leva, L | 1 |
| Giannone, AG | 1 |
| Cabibi, D | 1 |
| Vinciguerra, M | 1 |
| Inoue-Yamauchi, A | 1 |
| Itagaki, H | 1 |
| Oda, H | 1 |
| Wu, Y | 1 |
| Shan, B | 1 |
| Dai, J | 1 |
| Xia, Z | 1 |
| Cai, J | 1 |
| Chen, T | 1 |
| Lv, S | 1 |
| Feng, Y | 1 |
| Zheng, L | 1 |
| Wang, Y | 1 |
| Liu, J | 2 |
| Fang, J | 1 |
| Xie, D | 1 |
| Rui, L | 1 |
| Liu, Y | 1 |
| Casagrande, V | 1 |
| Mauriello, A | 1 |
| Anemona, L | 1 |
| Mavilio, M | 1 |
| Iuliani, G | 1 |
| De Angelis, L | 1 |
| D'Onofrio, M | 1 |
| Arisi, I | 1 |
| Federici, M | 1 |
| Menghini, R | 1 |
| Ohno, T | 3 |
| Shimizu, M | 6 |
| Shirakami, Y | 5 |
| Baba, A | 3 |
| Kochi, T | 3 |
| Kubota, M | 5 |
| Tsurumi, H | 4 |
| Tanaka, T | 6 |
| Moriwaki, H | 6 |
| Miyazaki, T | 1 |
| Ideta, T | 1 |
| Sakai, H | 5 |
| Iwasa, J | 2 |
| Shiraki, M | 1 |
| Terakura, Y | 1 |
| Takai, K | 2 |
| Park, EJ | 1 |
| Lee, JH | 1 |
| Yu, GY | 1 |
| He, G | 1 |
| Ali, SR | 1 |
| Holzer, RG | 1 |
| Osterreicher, CH | 1 |
| Takahashi, H | 1 |
| Karin, M | 1 |
| Yasuda, Y | 3 |
| Terakura, D | 2 |
| Hara, Y | 1 |
| Kuklin, AI | 1 |
| Mynatt, RL | 1 |
| Klebig, ML | 1 |
| Kiefer, LL | 1 |
| Wilkison, WO | 1 |
| Woychik, RP | 1 |
| Michaud, EJ | 1 |
12 other studies available for diethylnitrosamine and Obesity
| Article | Year |
|---|---|
Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin.
Topics: Aging; Animals; Dasatinib; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Disease Progr | 2021 |
Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; | 2018 |
Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytokines; Diet, High-Fat; Diethylnitrosamin | 2018 |
Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Progression; Fatty L | 2019 |
Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice.
Topics: Adipokines; Animals; Animals, Newborn; Carcinogenesis; Diabetes Mellitus, Experimental; Diethylnitro | 2015 |
Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.
Topics: Alginates; Animals; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Diethylnitrosa | 2016 |
Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice.
Topics: Alanine Transaminase; Amino Acids, Branched-Chain; Animals; Diabetes Complications; Dietary Suppleme | 2010 |
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Extracellular Signal-Reg | 2010 |
Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cytokines; Diabetes Complications; Diabetes Melli | 2011 |
Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Diabetes Mellitus, Experimental; D | 2011 |
Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Apoptosis; bcl-Associated Death Protein; Cocarc | 2011 |
Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes.
Topics: Agouti Signaling Protein; Albumins; Animals; Blood Glucose; Body Weight; Carcinogens; Diabetes Melli | 2004 |