Page last updated: 2024-11-08

diethylnitrosamine and Neoplasms

diethylnitrosamine has been researched along with Neoplasms in 49 studies

Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Our findings showed that in hepatocarcinogenesis by diethylnitrosamine, cellular senescence is associated with p16 pathway activation and is mainly localized in myofibroblast-like cells."5.43Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. ( Alemán-Lazarini, L; Arellanes-Robledo, J; Fattel-Fazenda, S; Pacheco-Rivera, R; Pérez-Carreón, J; Rodríguez-Segura, M; Serrano-Luna, J; Shibayama, M; Silva-Olivares, A; Villa-Treviño, S, 2016)
"1 ppm range, the dose-response for esophageal tumor formation was sublinear, possibly due to DNA repair."2.39N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. ( Verna, L; Whysner, J; Williams, GM, 1996)
"Our findings showed that in hepatocarcinogenesis by diethylnitrosamine, cellular senescence is associated with p16 pathway activation and is mainly localized in myofibroblast-like cells."1.43Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. ( Alemán-Lazarini, L; Arellanes-Robledo, J; Fattel-Fazenda, S; Pacheco-Rivera, R; Pérez-Carreón, J; Rodríguez-Segura, M; Serrano-Luna, J; Shibayama, M; Silva-Olivares, A; Villa-Treviño, S, 2016)
"Comparisons on a linear and the Rozman logarithmic scale for dosage versus carcinogenicity in rodents are presented for methyl eugenol (ME), nitrosodiethylamine (NDEA), ethyl carbamate (EC) and 2-acetylaminofluorene (AAF)."1.33Comparisons of thresholds for carcinogenicity on linear and logarithmic dosage scales. ( Waddell, WJ, 2005)
"The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0."1.31Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001)
" The second step is evaluation of the independent dose-response relationships observed in animals and prediction of human risk distributions by normalizing time units with respect to species natural life span."1.28Scaling of fatal cancer risks from laboratory animals to man. ( Raabe, OG, 1989)
"In the other type, tumors differ from one another essentially via their growth rates."1.27The early growth of cancer. ( Chover, J; King, JH, 1985)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-199034 (69.39)18.7374
1990's2 (4.08)18.2507
2000's5 (10.20)29.6817
2010's5 (10.20)24.3611
2020's3 (6.12)2.80

Authors

AuthorsStudies
Li, K1
Ricker, K1
Tsai, FC1
Hsieh, CJ1
Osborne, G1
Sun, M1
Marder, ME1
Elmore, S1
Schmitz, R1
Sandy, MS1
Gamal-Eldeen, AM1
Amer, H1
Alrehaili, AA1
Saleh, A1
Al Ghamdi, AE1
Hawsawi, NM1
Salman, A1
Raafat, BM1
Kay, JE1
Corrigan, JJ1
Armijo, AL1
Nazari, IS1
Kohale, IN1
Torous, DK1
Avlasevich, SL1
Croy, RG1
Wadduwage, DN1
Carrasco, SE1
Dertinger, SD1
White, FM1
Essigmann, JM1
Samson, LD1
Engelward, BP1
Al-Kindi, SG1
Oliveira, GH1
Walesky, C1
Apte, U1
Pacheco-Rivera, R1
Fattel-Fazenda, S1
Arellanes-Robledo, J1
Silva-Olivares, A1
Alemán-Lazarini, L1
Rodríguez-Segura, M1
Pérez-Carreón, J1
Villa-Treviño, S1
Shibayama, M1
Serrano-Luna, J1
Iatropoulos, MJ1
Cerven, DR1
de George, G1
von Keutz, E1
Williams, GM2
Herranz, D1
Muñoz-Martin, M1
Cañamero, M1
Mulero, F1
Martinez-Pastor, B1
Fernandez-Capetillo, O1
Serrano, M1
Lin, H1
Hu, L1
Chen, L1
Yu, H1
Wang, Q1
Chen, P1
Hu, XT1
Cai, XJ1
Guan, XY1
Rajeshkumar, NV1
Pillai, MR1
Kuttan, R1
DONTENWILL, W3
MOHR, U2
THOMAS, C4
HERROLD, KM3
DUNHAM, LJ1
HOBIK, HP1
GRUNDMANN, E1
SCHMAHL, D2
KONIG, K1
ARGUS, MF1
HOCH-LIGETI, C1
REID, JD1
RILEY, JF1
SHEPHERD, DM1
SYDOW, G1
DRUCKREY, H1
SCHILDBACH, A1
SCHMAEHL, D2
PREUSSMANN, R1
IVANKOVIC, S1
STANTON, MF1
RAPP, HJ1
CARLETON, JH1
CRISLER, C1
NADEL, EM1
WIEBECKE, B1
FEL, VIa1
TSIKARISHVILI, TN1
SHVEMBERGER, IN1
SCHELD, G1
Waddell, WJ1
Swann, PF1
Peto, R1
Gray, R1
Brantom, P1
Grasso, P1
Scherf, HR1
Griciute, L1
Castegnaro, M1
Béréziat, JC1
Farber, E1
Brittebo, EB1
Lindgren, A1
Tjälve, H1
Verna, L1
Whysner, J1
Watanabe, T1
Sugie, S1
Okamoto, K1
Rahman, KM1
Ushida, J1
Mori, H1
Clapp, NK1
Tyndall, RL1
Colyer, S1
Clapp, N1
Albert, RE1
Altshuler, B1
Mirowski, M1
Hanausek, M1
Sherman, U1
Adams, AK1
Walaszek, Z1
Slaga, TJ1
Raabe, OG1
Krasil'schikov, DG1
Barauskaĭte, SV1
Jeney, A1
Garry, VF1
Jacobs, DR1
Kreiger, RA1
Nelson, RL1
Loeppky, R1
Harkins, ME1
Chover, J1
King, JH1
Wilhelmsson, B1
Lundh, B1
Drettner, B1

Reviews

5 reviews available for diethylnitrosamine and Neoplasms

ArticleYear
Role of hepatocyte nuclear factor 4α (HNF4α) in cell proliferation and cancer.
    Gene expression, 2015, Volume: 16, Issue:3

    Topics: Animals; Cell Differentiation; Cell Proliferation; Diethylnitrosamine; Hepatocyte Nuclear Factor 4;

2015
N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation.
    Pharmacology & therapeutics, 1996, Volume: 71, Issue:1-2

    Topics: Animals; Biotransformation; Carcinogens; Diethylnitrosamine; DNA; DNA Adducts; Humans; Mutagenicity

1996
N-nitrosodiethanolamine.
    IARC monographs on the evaluation of carcinogenic risks to humans, 2000, Volume: 77

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Cricetinae; Diethylnitrosamine; Disease Models, Animal;

2000
[Modified effect of ethanol on blastomogenesis induced by carcinogenic substances].
    Gigiena i sanitariia, 1989, Issue:4

    Topics: Alcoholic Beverages; Animals; Cocarcinogenesis; Diethylnitrosamine; Drug Synergism; Ethanol; Humans;

1989
Trends in pathobiochemical studies of tumour development and progression.
    Acta morphologica Hungarica, 1986, Volume: 34, Issue:4

    Topics: Animals; Cell Transformation, Neoplastic; Chromatin; Diethylnitrosamine; DNA; Homeostasis; Humans; L

1986

Other Studies

44 other studies available for diethylnitrosamine and Neoplasms

ArticleYear
Estimated Cancer Risks Associated with Nitrosamine Contamination in Commonly Used Medications.
    International journal of environmental research and public health, 2021, 09-08, Volume: 18, Issue:18

    Topics: Animals; Carcinogens; Diabetes Mellitus, Type 2; Diethylnitrosamine; Dimethylnitrosamine; Neoplasms;

2021
Cancer Chemopreventive Properties of Sulfated
    Nutrition and cancer, 2021, Volume: 73, Issue:5

    Topics: Animals; Antioxidants; Diethylnitrosamine; Fabaceae; Female; Humans; Neoplasms; Placenta; Plant Extr

2021
Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice.
    Cell reports, 2021, 03-16, Volume: 34, Issue:11

    Topics: Animals; Biomarkers, Tumor; Cell Death; Chromosomal Instability; Diethylnitrosamine; Disease Suscept

2021
Abrupt Increase in Reporting of Neoplasms Associated with Valsartan After Medication Recall.
    Circulation. Cardiovascular quality and outcomes, 2019, Volume: 12, Issue:7

    Topics: Adverse Drug Reaction Reporting Systems; Angiotensin II Type 1 Receptor Blockers; Carcinogens; Dieth

2019
Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine.
    Toxicology letters, 2016, Jan-22, Volume: 241

    Topics: Animals; beta-Galactosidase; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell Proliferation; Cel

2016
Reduction by dietary matrix metalloproteinase inhibitor BAY 12-9566N of neoplastic development induced by diethylnitrosamine, N-nitrosodimethylamine, or 7,12-dimethylbenz(a)anthracene in rats.
    Drug and chemical toxicology, 2008, Volume: 31, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Antineoplastic Agents; Biphenyl Compounds; Carci

2008
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
    Nature communications, 2010, Apr-12, Volume: 1

    Topics: Aging; Animals; Dietary Fats; Diethylnitrosamine; DNA Damage; Female; Glucose Tolerance Test; Liver

2010
Chemically-induced cancers do not originate from bone marrow-derived cells.
    PloS one, 2012, Volume: 7, Issue:1

    Topics: Abnormal Karyotype; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carcinogens; Cell Trans

2012
Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis.
    Journal of experimental & clinical cancer research : CR, 2003, Volume: 22, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Carcinogens; cdc25 Phosphatases; Cell Line, Tumor; Chromatography,

2003
[On tracheal and bronchial carcinoma in the golden hamster after treatment with diethylnitrosamine].
    Klinische Wochenschrift, 1961, May-01, Volume: 39

    Topics: Animals; Bronchi; Bronchial Neoplasms; Carcinogens; Carcinoma, Bronchogenic; Cricetinae; Diethylnitr

1961
[On the morphology of diethylnitrosamine induced liver changes and tumors in rats].
    Zeitschrift fur Krebsforschung, 1961, Volume: 64

    Topics: Amines; Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Neoplasms; Rats

1961
[Carcinoma of the respiratory tract following treatment of the golden hamster with diethylnitrosamine].
    Zeitschrift fur Krebsforschung, 1961, Volume: 64

    Topics: Amines; Animals; Carcinogens; Carcinoma; Cricetinae; Diethylnitrosamine; Humans; Mesocricetus; Neopl

1961
Induction of tumors in the Syrian hamster with diethylnitrosamine (N-nitrosodiethylamine).
    Cancer research, 1963, Volume: 23

    Topics: Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Ethylamines; Humans; Mesocricetus; Neoplasms;

1963
[Quantitative DNA and RNA changes in the rat liver cell during diethylnitrosamine carcinogenesis].
    Beitrage zur pathologischen Anatomie und zur allgemeinen Pathologie, 1962, Volume: 127

    Topics: Animals; Carcinogenesis; Diethylnitrosamine; DNA; DNA, Neoplasm; Hepatocytes; Liver; Neoplasms; Nitr

1962
[Experimental studies on "syncarcinogenesis". 1. Experiments on cancer induction in rats with simultaneous application of diethylnitrosamine and 4-dimethylaminoazobenzene].
    Zeitschrift fur Krebsforschung, 1963, Volume: 65

    Topics: Animals; Diethylnitrosamine; Neoplasms; Neoplasms, Experimental; Nitroso Compounds; p-Dimethylaminoa

1963
Induction of malignant tumors in the guinea pig by oral administration of diethylnitrosamine.
    Journal of the National Cancer Institute, 1963, Volume: 30

    Topics: Administration, Oral; Diethylnitrosamine; Guinea Pigs; Liver Neoplasms; Lung Neoplasms; Neoplasms; N

1963
HISTOLOGICAL AND ENZYMATIC CHANGES IN THE LIVERS OF RATS FED THE HEPATIC CARCINOGEN DIETHYLNITROSAMINE.
    Biochemical pharmacology, 1963, Volume: 12

    Topics: Carboxy-Lyases; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dopa Decarboxylase; Hist

1963
INDUCTION OF OLFACTORY NEUROEPITHELIAL TUMORS IN SYRIAN HAMSTERS BY DIETHYLNITROSAMINE.
    Cancer, 1964, Volume: 17

    Topics: Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Histology; Mesocricetus; Neoplasms; Neoplasms,

1964
[THE HEXOKINASE ACTIVITY IN THE MITOCHONDRIA OF THE PRECANCEROUS RAT LIVER AND TRANSPLANTED DIETHYLNITROSAMINE HEPATOMA].
    Acta biologica et medica Germanica, 1964, Volume: 13

    Topics: Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylnitrosamine;

1964
[QUANTITATIVE ANALYSIS OF THE CARCINOGENIC EFFECT OF DIETHYLNITROSAMINE].
    Arzneimittel-Forschung, 1963, Volume: 13

    Topics: Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA; DNA, Neoplasm; Esophageal Neoplasms

1963
EFFECT OF ROUTE OF ADMINISTRATION ON THE CARCINOGENIC ACTION OF DIETHYLNITROSAMINE (N-NITROSODIETHYLAMINE).
    British journal of cancer, 1964, Volume: 18

    Topics: Animals; Bronchial Neoplasms; Carcinogens; Cricetinae; Diethylnitrosamine; Female; Humans; Injection

1964
DIETHYLNITROSAMINE-INDUCED HEPATIC DEGENERATION AND NEOPLASIA IN THE AQUARIUM FISH, BRACHYDANIO RERIO.
    Journal of the National Cancer Institute, 1965, Volume: 34

    Topics: Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Fishes; Hepatitis;

1965
INDUCTION OF MALIGNANT TUMORS IN THE RABBIT BY ORAL ADMINISTRATION OF DIETHYLNITROSAMINE.
    Journal of the National Cancer Institute, 1965, Volume: 34

    Topics: Administration, Oral; Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Lung Neoplasms; Neo

1965
[AUTORADIOGRAPHIC STUDIES DURING EXPERIMENTAL CARCINOGENESIS IN THE RESPIRATORY TRACT OF THE HAMSTER AFTER TREATMENT WITH DIETHYLNITROSAMINE].
    Zeitschrift fur Krebsforschung, 1964, Nov-02, Volume: 66

    Topics: Animals; Autoradiography; Carcinogenesis; Cricetinae; Diethylnitrosamine; Neoplasms; Neoplasms, Expe

1964
[ON ANTIGENIC CHARACTERISTICS OF HEPATOMAS PRODUCED IN RATS WITH N-NITROSODIETHYLAMINE].
    Voprosy onkologii, 1964, Volume: 10

    Topics: Antigens; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethylamines; Liver Neoplasms; Neoplasms; Ne

1964
[THE TOXIC AND CARCINOGENIC EFFECTS OF DIETHYLNITROSAMINE IN RATS DURING SIMULTANEOUS TREATMENT WITH A LIVER PROTECTIVE AGENT].
    Arzneimittel-Forschung, 1964, Volume: 14

    Topics: Amino Acids; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Neoplasms; Neoplasms, Experimental; N

1964
Comparisons of thresholds for carcinogenicity on linear and logarithmic dosage scales.
    Human & experimental toxicology, 2005, Volume: 24, Issue:6

    Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; E

2005
Diazepam and tumour promotion.
    Lancet (London, England), 1981, Feb-21, Volume: 1, Issue:8217

    Topics: Animals; Cocarcinogenesis; Diazepam; Diethylnitrosamine; Female; Humans; Neoplasms; Neoplasms, Exper

1981
[The significance of environmental factors for the cancerogenesis in old age by the model of iatrogenic carcinogenesis (author's transl)].
    Aktuelle Gerontologie, 1981, Volume: 11, Issue:2

    Topics: Aged; Diethylnitrosamine; Gastrointestinal Diseases; Humans; Liver Neoplasms; Neoplasms; Skin Neopla

1981
Effect of ethanol on nitrosamine metabolism and distribution. Implications for the role of nitrosamines in human cancer and for the influence of alcohol consumption on cancer incidence.
    IARC scientific publications, 1984, Issue:57

    Topics: Alcohol Drinking; Animals; Cocarcinogenesis; Diethylnitrosamine; Dimethylnitrosamine; Ethanol; Human

1984
Nitrosamine carcinogenesis in 5120 rodents: chronic administration of sixteen different concentrations of NDEA, NDMA, NPYR and NPIP in the water of 4440 inbred rats, with parallel studies on NDEA alone of the effect of age of starting (3, 6 or 20 weeks) a
    IARC scientific publications, 1984, Issue:57

    Topics: Age Factors; Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Female; Male; Mesocricetu

1984
Carcinogenic activity of N-nitrosodiethylamine in snakes (Python reticulatus, Schneider).
    IARC scientific publications, 1984, Issue:57

    Topics: Animals; Diethylnitrosamine; Neoplasms; Nitrosamines; Snakes

1984
Influence of ethyl alcohol on carcinogenesis induced with N-nitrosodiethylamine.
    IARC scientific publications, 1984, Issue:56

    Topics: Animals; Diethylnitrosamine; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains;

1984
Chemicals, evolution, and cancer development: Rous-Whipple Award Lecture.
    The American journal of pathology, 1982, Volume: 108, Issue:3

    Topics: Adult; Aflatoxin B1; Aflatoxins; Animals; Biological Evolution; Carcinogens; Carcinogens, Environmen

1982
Foetal distribution and metabolism of N-nitrosodiethylamine in mice.
    Acta pharmacologica et toxicologica, 1981, Volume: 48, Issue:4

    Topics: Acetates; Animals; Autoradiography; Carbon Radioisotopes; Diethylnitrosamine; Female; Fetus; Gestati

1981
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:6

    Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce

2001
interactions of ionizing radiation, nitrosamines, sulfonoxyalkanes and antioxidants as they affect carcinogenesis and survival in mice.
    American Industrial Hygiene Association journal, 1978, Volume: 39, Issue:6

    Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Carcinogens; Cocarcinogenesis; Cresols; Diethylnitr

1978
Early alterations in plasma esterases with associated pathology following oral administration of diethylnitrosamine and butylated hydroxytoluene singly or in combination.
    International journal of cancer, 1975, Jul-15, Volume: 16, Issue:1

    Topics: Administration, Oral; Animals; Butylated Hydroxytoluene; Cell Transformation, Neoplastic; Cresols; D

1975
Assessment of environmental carcinogen risks in terms of life shortening.
    Environmental health perspectives, 1976, Volume: 13

    Topics: Carcinogens; Diethylnitrosamine; Germany; Humans; Japan; Life Expectancy; Male; Neoplasms; Risk; Sto

1976
An enzyme-linked immunosorbent assay for p65 oncofetal protein and its potential as a new marker for cancer risk assessment in rodents and humans.
    Progress in clinical and biological research, 1992, Volume: 374

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Choline; Choline Deficiency; Diethylni

1992
Scaling of fatal cancer risks from laboratory animals to man.
    Health physics, 1989, Volume: 57 Suppl 1

    Topics: Animals; Bone Neoplasms; Diethylnitrosamine; Dogs; Dose-Response Relationship, Drug; Dose-Response R

1989
Integration of laboratory and epidemiologic studies to evaluate genotoxic exposure in tool and die workers.
    Progress in clinical and biological research, 1986, Volume: 207

    Topics: Biotransformation; Chromatography, High Pressure Liquid; Chromosome Aberrations; Diethylnitrosamine;

1986
The early growth of cancer.
    Journal of mathematical biology, 1985, Volume: 21, Issue:3

    Topics: Animals; Cell Division; Diethylnitrosamine; Liver Neoplasms; Male; Mathematics; Mice; Models, Biolog

1985
Effects of wood dust exposure and diethylnitrosamine in an animal experimental system.
    Rhinology, 1985, Volume: 23, Issue:2

    Topics: Adenocarcinoma; Animals; Cricetinae; Diethylnitrosamine; Dust; Environmental Exposure; Laryngeal Neo

1985