diethylnitrosamine has been researched along with Metastase in 28 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Incidences of lung metastasis in the 40 ppm group steadily increased up to 67% by week 36 while that in the 80 ppm increased sharply up to 86% by week 24." | 5.33 | Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. ( Cho, YM; Futakuchi, M; Imai, N; Ogawa, K; Shirai, T; Takeshita, F; Tamano, S; Yoshino, H, 2005) |
| " The aim of this study was to investigate the inhibitory effect of a glycoprotein (38 kDa) isolated from Styrax japonica Siebold et al Zuccarini (SJSZ) on metastasis of hepatocellular carcinoma (HCC) in diethylnitrosamine (DEN)-treated imprinting control region (ICR) mice." | 3.78 | Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice. ( Lee, J; Lim, KT, 2012) |
| "The frequency of metastases of malignant diethylnitrosamine-induced hepatomas and haemangioendotheliomas of the liver of female Sprague-Dawley rats (29%) was not influenced by application of acetyl-salicylic acid or phenprocoumon." | 3.65 | [Studies on the influence of anticoagulants on metastase formation of autochthonic hepatomas in the rat (author's transl)]. ( Schmähl, D, 1975) |
| "And Wrh-f2 developed stable pulmonary metastasis." | 1.56 | Establishment of rat liver cancer cell lines with different metastatic potential. ( Feng, X; Hou, J; Liu, SF; Song, L; Zhang, HL; Zhang, JG; Zheng, L, 2020) |
| "The high recurrence/metastasis of HCC is the main cause of death for HCC patients after liver resection." | 1.46 | miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver. ( Chen, XB; Feng, L; Tang, JW; Xu, LL; Xu, MQ; Yi, PS; Zhang, M; Zheng, XB, 2017) |
| "Incidences of lung metastasis in the 40 ppm group steadily increased up to 67% by week 36 while that in the 80 ppm increased sharply up to 86% by week 24." | 1.33 | Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. ( Cho, YM; Futakuchi, M; Imai, N; Ogawa, K; Shirai, T; Takeshita, F; Tamano, S; Yoshino, H, 2005) |
| "Although no lung metastasis was observed in the rats killed at the end of the period of carcinogen exposure, lung metastasis was found in 100% of animals in all the groups at the end of the experiment." | 1.32 | Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma. ( Futakuchi, M; Ogawa, K; Shirai, T; Takahashi, S; Tamano, S, 2004) |
| "For better understanding of cancer metastasis, we have established an in vivo model for induction of highly metastatic hepatocellular carcinomas (HCC) in male F344 rats." | 1.31 | Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice. ( Asamoto, M; Futakuchi, M; Imaida, K; Nakanishi, H; Ogawa, K; Shirai, T; Takeshita, F; Tatematsu, M, 2001) |
| "The most common form of metastasis was trans-coelomic, followed by direct invasion and distant metastasis, presumably via the vascular route." | 1.30 | Progression of hepatic neoplasia in medaka (Oryzias latipes) exposed to diethylnitrosamine. ( Hinton, DE; Okihiro, MS, 1999) |
| "4 mg/kg body weight with a total dosage of 420 mg/kg over an experimental period of five years." | 1.26 | Hepatocarcinogenetic effect of DENA in pigs. ( Berg, H; Graw, JJ, 1977) |
| "The pulmonary metastases were first detected in mice dying between 51 and 60 weeks of age (5%)." | 1.26 | Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice. ( Mihailovich, N; Rao, KV; Vesselinovitch, SD, 1978) |
| " DMN induced a considerable quantity of liver tumours, the highest incidence being demonstrated in the lowest dosage group." | 1.26 | Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine. ( Kmoch, N; Mohr, U; Reznik, G, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (35.71) | 18.7374 |
| 1990's | 4 (14.29) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Song, L | 1 |
| Zhang, JG | 1 |
| Zheng, L | 1 |
| Feng, X | 1 |
| Hou, J | 1 |
| Zhang, HL | 1 |
| Liu, SF | 1 |
| Hsu, SH | 1 |
| Wang, B | 1 |
| Kutay, H | 1 |
| Bid, H | 1 |
| Shreve, J | 1 |
| Zhang, X | 1 |
| Costinean, S | 1 |
| Bratasz, A | 1 |
| Houghton, P | 1 |
| Ghoshal, K | 1 |
| Bhatia, N | 1 |
| Gupta, P | 1 |
| Singh, B | 1 |
| Koul, A | 1 |
| Sun, WY | 1 |
| Hu, SS | 1 |
| Wu, JJ | 1 |
| Huang, Q | 1 |
| Ma, Y | 1 |
| Wang, QT | 1 |
| Chen, JY | 1 |
| Wei, W | 1 |
| Zheng, XB | 1 |
| Chen, XB | 1 |
| Xu, LL | 1 |
| Zhang, M | 1 |
| Feng, L | 1 |
| Yi, PS | 1 |
| Tang, JW | 1 |
| Xu, MQ | 1 |
| Lee, J | 1 |
| Lim, KT | 1 |
| Hueper, K | 1 |
| Elalfy, M | 1 |
| Laenger, F | 1 |
| Halter, R | 1 |
| Rodt, T | 1 |
| Galanski, M | 1 |
| Borlak, J | 1 |
| Srivastava, J | 1 |
| Siddiq, A | 1 |
| Emdad, L | 1 |
| Santhekadur, PK | 1 |
| Chen, D | 2 |
| Gredler, R | 1 |
| Shen, XN | 1 |
| Robertson, CL | 1 |
| Dumur, CI | 1 |
| Hylemon, PB | 1 |
| Mukhopadhyay, ND | 1 |
| Bhere, D | 1 |
| Shah, K | 1 |
| Ahmad, R | 1 |
| Giashuddin, S | 1 |
| Stafflinger, J | 1 |
| Subler, MA | 1 |
| Windle, JJ | 1 |
| Fisher, PB | 1 |
| Sarkar, D | 1 |
| Heindryckx, F | 1 |
| Coulon, S | 1 |
| Terrie, E | 1 |
| Casteleyn, C | 1 |
| Stassen, JM | 1 |
| Geerts, A | 1 |
| Libbrecht, L | 1 |
| Allemeersch, J | 1 |
| Carmeliet, P | 1 |
| Colle, I | 1 |
| Van Vlierberghe, H | 1 |
| RAPP, HJ | 1 |
| CARLETON, JH | 1 |
| CRISLER, C | 1 |
| NADEL, EM | 1 |
| Futakuchi, M | 3 |
| Ogawa, K | 3 |
| Tamano, S | 2 |
| Takahashi, S | 1 |
| Shirai, T | 3 |
| Yoshino, H | 1 |
| Cho, YM | 1 |
| Takeshita, F | 2 |
| Imai, N | 1 |
| Lijinsky, W | 1 |
| Reuber, MD | 2 |
| Manning, WB | 1 |
| Laconi, E | 1 |
| Vasudevan, S | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| Pani, P | 1 |
| Sarma, DS | 1 |
| Okihiro, MS | 1 |
| Hinton, DE | 1 |
| Ceriello, A | 1 |
| Mezza, F | 1 |
| Cozzolino, S | 1 |
| Pettinato, G | 1 |
| Mancini, A | 1 |
| Santaniello, W | 1 |
| Calise, F | 1 |
| Cuomo, O | 1 |
| Nakanishi, H | 1 |
| Asamoto, M | 1 |
| Imaida, K | 1 |
| Tatematsu, M | 1 |
| Chen, H | 1 |
| Diao, L | 1 |
| Li, H | 1 |
| Liu, M | 1 |
| Hashimoto, S | 1 |
| Sueishi, K | 1 |
| Scherer, E | 1 |
| Emmelot, P | 1 |
| Graw, JJ | 1 |
| Berg, H | 1 |
| Craddock, VM | 1 |
| Schmähl, D | 1 |
| Solt, DB | 1 |
| Hay, JB | 1 |
| Farber, E | 1 |
| Vesselinovitch, SD | 1 |
| Mihailovich, N | 1 |
| Rao, KV | 1 |
| Reznik, G | 1 |
| Mohr, U | 1 |
| Kmoch, N | 1 |
| Fullerton, FR | 1 |
| Hoover, K | 1 |
| Mikol, YB | 1 |
| Creasia, DA | 1 |
| Poirier, LA | 1 |
1 review available for diethylnitrosamine and Metastase
| Article | Year |
|---|---|
[Basic research on lung cancer].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Genes, Tumor Suppressor; Growth Substances; His | 2002 |
27 other studies available for diethylnitrosamine and Metastase
| Article | Year |
|---|---|
Establishment of rat liver cancer cell lines with different metastatic potential.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Disease Models, Animal; Ka | 2020 |
Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure.
Topics: Alkylating Agents; Animals; Axl Receptor Tyrosine Kinase; Carcinoma, Hepatocellular; cdc25 Phosphata | 2013 |
Lycopene Enriched Tomato Extract Inhibits Hypoxia, Angiogenesis, and Metastatic Markers in early Stage N-Nitrosodiethylamine Induced Hepatocellular Carcinoma.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carotenoids; Cell Hypoxia; Dietary Supplements; | 2015 |
Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma.
Topics: Animals; beta-Arrestin 2; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement | 2016 |
miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver.
Topics: Animals; Calpain; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethylnitrosamine; | 2017 |
Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; DNA Pr | 2012 |
PET/CT imaging of c-Myc transgenic mice identifies the genotoxic N-nitroso-diethylamine as carcinogen in a short-term cancer bioassay.
Topics: Animals; Carcinogens; Cell Proliferation; Diagnostic Imaging; Diethylnitrosamine; Glucose; Liver Neo | 2012 |
Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Transformat | 2012 |
The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamin | 2013 |
INDUCTION OF MALIGNANT TUMORS IN THE RABBIT BY ORAL ADMINISTRATION OF DIETHYLNITROSAMINE.
Topics: Administration, Oral; Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Lung Neoplasms; Neo | 1965 |
Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma.
Topics: Acetylcysteine; Animals; Aspirin; Blotting, Western; Carcinogens; Diethylnitrosamine; E-Selectin; En | 2004 |
Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine.
Topics: Alkylating Agents; Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode | 2005 |
Potent carcinogenicity of nitrosodiethanolamine in rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver Neoplasms, | 1980 |
Increasing the interval between initiation and the onset of exposure to orotic acid decreases its promoting effect on rat liver carcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver Neoplasms, Experimental; Male; Neopl | 1993 |
Progression of hepatic neoplasia in medaka (Oryzias latipes) exposed to diethylnitrosamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms, Experimental; Neoplasm Metastasis; Oryzia | 1999 |
Role of immunosuppression in recurrence after liver transplantation for diethylnitrosamine-induced tumors in rats.
Topics: Animals; Cyclosporine; Diethylnitrosamine; Graft Survival; Immunosuppressive Agents; Liver Neoplasms | 1994 |
Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice.
Topics: Animals; Blotting, Northern; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Primers; Female; Hum | 2001 |
[Dynamic study on expression of gelatinase A and its natural inhibitor during invasion and metastasis of induced lung cancer in Wistar rats].
Topics: Alkylating Agents; Animals; Carcinoma, Squamous Cell; Diethylnitrosamine; Female; Gene Expression Re | 2002 |
Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine | 1975 |
Hepatocarcinogenetic effect of DENA in pigs.
Topics: Animals; Carcinoma; Diethylnitrosamine; Liver Neoplasms; Neoplasm Metastasis; Neoplasms, Experimenta | 1977 |
Effect of a single treatment with the alkylating carcinogens dimethynitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. I. Test for induction of liver carcinomas.
Topics: Adenocarcinoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethylnitrosamine; Female; | 1975 |
[Studies on the influence of anticoagulants on metastase formation of autochthonic hepatomas in the rat (author's transl)].
Topics: Animals; Anticoagulants; Aspirin; Carcinoma, Hepatocellular; Coumarins; Diethylnitrosamine; Female; | 1975 |
Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver Neoplasms; Lung; Male; Mi | 1977 |
Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice.
Topics: Animals; Benzidines; Benzopyrenes; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethylnitrosourea; | 1978 |
Effect of age and sex on lesions of the esophagus in Buffalo strain rats ingesting diethylnitrosamine.
Topics: Age Factors; Animals; Diethylnitrosamine; Esophageal Neoplasms; Female; Liver Neoplasms; Male; Neopl | 1976 |
Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine.
Topics: Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Esop | 1976 |
The inhibition by methionine and choline of liver carcinoma formation in male C3H mice dosed with diethylnitrosamine and fed phenobarbital.
Topics: Animals; Choline; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Methionine; Mice; | 1990 |