diethylnitrosamine has been researched along with Liver Neoplasms in 1003 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the effect of combined therapy of diacerein and gold nanoparticles (AuNP) on diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in a rat model." | 8.31 | Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study. ( Baokbah, TAS, 2023) |
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 8.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "This study was designed to evaluate the potential protective impact of estrogen and estrogen receptor against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 8.31 | Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis. ( Abdel-Hamid, MS; Abdelhady, R; El-Sayed, EM; Elsadek, BEM; Hassan, MH; Mansour, AM; Salama, SA, 2023) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 8.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| "This study aimed to evaluate the cancer chemopreventive activity of vanillic acid (VA) in diethylnitrosamine- and 1,2-dimethylhydrazine-induced liver and colon carcinogenesis in rats." | 8.02 | Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats. ( Chariyakornkul, A; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2021) |
| " The present study investigates the anticancer activity of ligand-L and its mode of action in rat model of diethylnitrosamine (DEN) induced hepatocellular carcinoma." | 7.96 | Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma. ( Khan, S; Naseem, I; Zafar, A, 2020) |
| "This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment." | 7.96 | Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020) |
| " Nimbolide is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties; however, its anticancer effects and molecular mechanism in hepatocellular carcinoma (HCC) remains obscure." | 7.96 | Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis. ( Ram, AK; Srinivas, BH; Vairappan, B, 2020) |
| " In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanoparticles (GaNPs) combined with low level of gamma radiation (IR), on the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 7.91 | Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats. ( El-Sonbaty, SM; Mansour, SZ; Moawed, FS, 2019) |
| "Mito-TEMPO was effective in combating hepatocarcinogenesis." | 7.91 | Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. ( Bharati, S; Kumar, R; Shetty, S, 2019) |
| " Diethylnitrosamine (DEN) is one of the recognized risk factors for hepatocarcinogenesis likely due to CYP2E1-mediated metabolic activation." | 7.88 | Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine. ( Chang, Z; Fang, Y; Gao, J; Gao, N; Jin, H; Qiao, HL; Wang, CE; Wang, GJ; Wang, J; Wang, Z; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 7.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| "Rationale of this study was framed to investigate the protective effect and anti-cancer property of nanoparticles based on chitosan isolated from squid, Sepioteuthis lessoniana, on hepatic cells in N-Nitrosodiethylamine-induced hepatocellular carcinoma in rats." | 7.85 | Chitosan nanoparticles from marine squid protect liver cells against N-diethylnitrosoamine-induced hepatocellular carcinoma. ( Shanmugam, A; Shanmugam, V; Subhapradha, N, 2017) |
| "This study aimed to evaluate the antitumor activity of platinum nanoparticles compared with cis-platin both in vitro and in vivo in the treatment of hepatocellular carcinoma induced in rats." | 7.85 | Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats. ( El-Sonbaty, S; Kandil, E; Mahmoud, M; Mansour, S; Medhat, A, 2017) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 7.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 7.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| " The aim of this study was to evaluate the anti-tumor effect of Celastrol against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats and furthermore, to explore the underlying mechanism." | 7.83 | Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. ( Chang, W; He, W; Li, PP; Lu, JT; Song, SS; Wei, W; Yuan, PF, 2016) |
| " The present investigation was carried out to evaluate antioxidant status and lipid peroxidation level of anticancer activity of Solanum xanthocarpum (SXC) on Diethylnitrosamine (DEN) induced hepato carcinogenesis in male Wistar albino rats." | 7.83 | Evaluation of antioxidant and stabilizing lipid peroxidation nature of Solanum xanthocarpum leaves in experimentally diethylnitrosamine induced hepatocellular carcinogenesis. ( Indumathi, D; Iyappan, P; Velu, P; Vijayalakshmi, A, 2016) |
| " To further confirm our hypothesis in vivo, we induced hepatocellular carcinoma (HCC) in rats by diethylnitrosamine (DEN)." | 7.81 | Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate. ( Ahmad, A; Farhan, M; Hadi, SM; Naseem, I; Rizvi, A, 2015) |
| " The present study was envisaged to investigate the possible synergistic effect of combined treatment of curcumin with piperine in suppression of diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats, owing to permeability enhancing effect of latter." | 7.81 | Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. ( Padwad, YS; Patial, V; Pratap, K; S, M; Sharma, S; Singh, D, 2015) |
| " The aim of this study was to investigate molecular mechanisms for the chemopreventive effects of folic acid and tributyrin alone or in combination on rat hepatocarcinogenesis." | 7.80 | Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. ( Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V, 2014) |
| "We investigated the possible therapeutic effect of irreversible proteasome inhibitor, carfilzomib against hepatocellular carcinoma induced chemically by chronic administration of diethylnitrosoamines (DENA)." | 7.80 | Possible role of selective, irreversible, proteasome inhibitor (carfilzomib) in the treatment of rat hepatocellular carcinoma. ( Al-Hosaini, K; Al-Rikabi, AC; Aljoufi, MA; Mansour, MA; Nagi, MN, 2014) |
| "The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model." | 7.80 | Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats. ( Geng, CZ; Liu, YP; Peng, L; Wang, SJ; Wang, X; Yang, HC; Zhao, JA, 2014) |
| "The possible molecular mechanisms of Nano-selenium (nano-se) in attenuating hepatocellular carcinoma (HCC) was investigated in this study." | 7.80 | Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats. ( Ahmed, HH; Hamza, AH; Khalil, WK, 2014) |
| " In the present study we found that DPAA significantly enhanced the development of diethylnitrosamine-induced preneoplastic lesions in the liver in a medium-term rat liver carcinogenesis assay." | 7.79 | Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. ( Fujioka, M; Kakehashi, A; Kato, M; Kitano, M; Tago, Y; Wanibuchi, H; Wei, M; Yamada, T; Yamano, S, 2013) |
| " We recently find that the loss of toll-like receptor 2 (TLR2) activities promotes the diethylnitrosamine (DEN) induced hepatocellular carcinogenesis and tumor progression, which associates with an abundant accumulation of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress." | 7.79 | Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. ( Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ, 2013) |
| "Modified Diethylnitrosamine (DEN)-induced primary hepatocellular carcinoma rat model was established." | 7.75 | [The expression of B-cell translocation gene 2 in diethylnitrosamine-induced primary hepatocellular carcinoma rat model.]. ( Chen, C; Jin, F; Li, Q; Li, ZP; Luo, XZ; Shan, JL; Wang, D; Wang, G; Xu, W; Yang, ZX; Zhang, ZM, 2009) |
| " To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma." | 7.75 | Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009) |
| " We induced hepatocellular carcinomas (HCCs) in rats with N-nitrosodiethylamine (DEN) and a choline-deficient l-amino acid-defined (CDAA) diet." | 7.74 | Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats. ( Honoki, K; Mori, C; Nishikawa, T; Onishi, M; Sokuza, Y; Tsujiuchi, T; Uwataki, K, 2007) |
| "Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear." | 7.74 | Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008) |
| " Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) increases the drug efficacy on HCCs induced in rats by diethylnitrosamine (DENA)." | 7.73 | Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine. ( Bolondi, L; Busi, C; Chieco, P; Di Stefano, G; Fiume, L; Kratz, F; Lanza, M; Mattioli, A, 2005) |
| " However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and efficacy of hydrodynamic injection via the tail vein and hepatic artery in a diethylnitrosamine (DEN)-induced HCC model in rats." | 7.73 | High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine. ( Hatano, E; Ikai, I; Koizumi, N; Nitta, T; Shimahara, Y; Tada, M; Taura, K, 2006) |
| "The effect of nodularin on selective atrophy of left lobes in the liver was investigated in F344 rats." | 7.71 | Selective left-lobe atrophy by nodularin treatment accompanied by reduced protein phosphatase 1/2A and increased peroxisome proliferation in rat liver. ( Choi, YK; Hyun, BH; Kwak, CS; Le, MS; Lim, IK; Park, SC; Park, TJ; Song, KY; Yoon, G, 2001) |
| " In this study we report that gavage administration of 200 mg/kg or 600 mg/kg CCM effectively suppressed diethylnitrosamine (DEN)-induced liver inflammation and hyperplasia in rats, as evidenced by histopathological examination." | 7.70 | Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. ( Cheng, AL; Chuang, SE; Kuo, ML; Lin, JK, 2000) |
| "The effects of treatments with diethylnitrosamine (DENA) and hepatitis B virus (HBV) on macaque monkeys were investigated by virus serology and by light and electron microscopy." | 7.65 | Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus. ( Cabral, GA; Gyorkey, F; Gyorkey, P; Hollinger, FB; Melnick, JL; Mirkovic, R, 1977) |
| "Hepatocellular carcinoma is the second most cause of death among the various cancers worldwide." | 5.91 | Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats. ( Amudha, P; Jayalakshmi, M; Poojitha, BN; Vidya, R, 2023) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 5.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| "Prunetin (PRU) is an O-methylated flavonoid that is present in various natural plants and a primary significant compound found in isoflavone." | 5.72 | Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats. ( Chen, H; Li, G; Qi, L; Tian, G, 2022) |
| "Boron has great potential to reduce the effects of oxidative stress, which may help it inhibit the progression of HCC." | 5.72 | Boron attenuated diethylnitrosamine induced hepatocellular carcinoma in C3H/HeN mice via alteration of oxidative stress and apoptotic pathway. ( Chen, J; Huang, H; Wang, J; Wei, Y; Wu, L; Yi, JK; Yin, X, 2022) |
| "Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality." | 5.62 | Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma. ( Balaraman, G; Krishnan, P; Mari, A; Salam, S; Sirajduddin, I; Subramaniam, N; Sundaram, J; Thiruvengadam, D, 2021) |
| " The study aimed to investigate the pharmacokinetic mechanism of herb-drug interactions between ADI and DOX in a rat model of HCC." | 5.62 | Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma. ( Cao, C; Chen, S; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zhang, S; Zhu, X, 2021) |
| "Alogliptin is an anti-diabetic that may have effective anticancer properties against many types of malignancies." | 5.62 | Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. ( Abd Elmaaboud, MA; Arab, HH; Kabel, AM, 2021) |
| "Liver cancer was induced in mice with hepatocyte-specific disruption of Myc and control mice by administration of diethylnitrosamine." | 5.62 | Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. ( Cai, J; Chen, L; Gao, Y; Gonzalez, FJ; Guo, X; Jiang, J; Krausz, KW; Liu, W; Luo, Y; Qu, A; Sun, L; Takahashi, S; Tang, W; Wang, Y; Xie, C; Yang, S; Yang, Y, 2021) |
| " However, the bioavailability of ABZ is very poor." | 5.62 | Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression. ( Amin, NA; Batiha, GE; El-Ahwany, E; El-Rous, MA; Elagamy, HI; Elewa, YHA; Elsergany, RN; Girgis, S; Gobba, NA; Hafez, AM; Kaddah, MMY; Kamal, I; Khodir, AE; Mahmoud, MH; Mourad, AAE; Nasr, M; Saad, AS; Saber, S; Shata, A, 2021) |
| "ET in the prevention of liver cancer is poorly understood." | 5.56 | Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine. ( Cao, L; Ding, S; Ji, B; Li, L; Qi, Z; Zhang, X, 2020) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 5.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| "Sorafenib (SO) is a multi-kinase inhibitor that targets upstream signals in the MAPK pathway." | 5.51 | Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma. ( Ghanim, AMH; Saber, S; Younis, NS, 2019) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 5.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "Primary hepatic angiosarcoma is a rare tumor with poor prognosis." | 5.51 | Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs. ( Golob-Schwarzl, N; Haybaeck, J; Hofer, EM; Hoppstädter, J; Kessler, SM; Lackner, C; Leber, B; Liegl-Atzwanger, B; Mischinger, HJ; Schultheiss, CS; Stiegler, P, 2019) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 5.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC)." | 5.48 | Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis. ( Inoue-Yamauchi, A; Itagaki, H; Oda, H, 2018) |
| "The global burden of hepatocellular carcinoma is increasing; actually, it is estimated as 750,000 new cases annually." | 5.46 | Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study. ( Aglan, HA; Ahmed, HH; El-Toumy, SA; Mahmoud, NS, 2017) |
| "Rats from all groups were assessed for liver cancer progression or inhibition by evaluating histological, biochemical, antioxidant enzyme status, cytokines and gene expression profiles." | 5.46 | Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats. ( Abuzenadah, A; Al-Qahtani, M; Barbour, E; Chaudhary, A; Kalamegam, G; Khan, F; Khan, TJ; Kumosani, T; Pushparaj, PN, 2017) |
| "Our findings showed that in hepatocarcinogenesis by diethylnitrosamine, cellular senescence is associated with p16 pathway activation and is mainly localized in myofibroblast-like cells." | 5.43 | Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. ( Alemán-Lazarini, L; Arellanes-Robledo, J; Fattel-Fazenda, S; Pacheco-Rivera, R; Pérez-Carreón, J; Rodríguez-Segura, M; Serrano-Luna, J; Shibayama, M; Silva-Olivares, A; Villa-Treviño, S, 2016) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 5.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "Caudatin is a potential antitumor agent isolated from the traditional Chinese medicine "baishouwu", which was the root tuber of Cynanchum auriculatum Royle ex Wight." | 5.42 | Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats. ( Ding, Y; Peng, Y, 2015) |
| "The treatment with astemizole prevented diethylnitrosamine (DEN)-induced rat HCC development in vivo (followed by studying γ-glutamyl transpeptidase (GGT) activity)." | 5.42 | Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1 channels as potential early-stage markers of HCC. ( Acuña-Macías, I; Camacho, J; Caro-Sánchez, CH; Chiliquinga, AJ; de Guadalupe Chávez-López, M; Díaz-Chávez, J; Gariglio, P; Hernández-Gallegos, E; Herrera, LA; Pérez-Carreón, JI; Zuñiga-García, V, 2015) |
| "Fgl1 expression is decreased in hepatocellular carcinoma (HCC) and its loss correlates with a poorly differentiated phenotype." | 5.42 | Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. ( Bronson, RT; Cohen, DE; Demchev, V; Desai, A; Hornick, JL; Nayeb-Hashemi, H; Ukomadu, C, 2015) |
| "Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date." | 5.42 | Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients. ( Hu, C; Huang, X; Lin, X; Niu, J; Tan, Y; Wang, H; Wang, X; Yin, P; Zeng, J; Zhou, L, 2015) |
| "Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 5.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
| "Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1α hepatic expression." | 5.40 | Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Hamed, O; Kazem, A; Nasr, M; Selima, E, 2014) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 5.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| "The findings suggest that RGP prevents hepatocellular carcinoma by suppressing the marked increase in the levels of serum marker enzymes, and suppresses the free radical by scavenging hydroxyl radicals." | 5.39 | Anticancer potential of rhamnocitrin 4'-β-D-galactopyranoside against N-diethylnitrosamine-induced hepatocellular carcinoma in rats. ( Ahmad, K; Ahmad, P; Al-Harbi, NO; Alam, MJ; Imam, F; Iqbal, M; Khusroo, MJ; Rahman, RU; Saleem, S; Shaharyar, MA, 2013) |
| " Simultaneously, hepatocarcinoma were induced in groups II-V by diethylnitrosamine (DEN) solution (100 mg/L) at the dosage of 10 mg/kg body weight every day as drinking water for 16 weeks, then sterilized water for a further two weeks." | 5.35 | Effect of selenium-enriched malt on hypoglycemia and regulatory hormones in diethylnitrosamine-induced hepatocarcinoma SD rats. ( Liu, JG; Liu, YJ; Wang, XL; Zhao, HJ, 2009) |
| "Incidences of lung metastasis in the 40 ppm group steadily increased up to 67% by week 36 while that in the 80 ppm increased sharply up to 86% by week 24." | 5.33 | Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. ( Cho, YM; Futakuchi, M; Imai, N; Ogawa, K; Shirai, T; Takeshita, F; Tamano, S; Yoshino, H, 2005) |
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 5.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| " To this end, chemical carcinogenesis protocols based on the injection of genotoxic compounds such as diethylnitrosamine (DEN) are widely used to model liver tumorigenesis in rodents." | 5.12 | Diethylnitrosamine-induced liver tumorigenesis in mice. ( Hasselblatt, P; Schulien, I, 2021) |
| " Six rats each were given tap water containing diethylnitrosamine (DEN) at 100 ppm for 8 or 14 weeks; Adenoma group and Hepatocellular carcinoma (HCC) group, respectively." | 4.31 | Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model. ( Jogo, A; Kageyama, K; Kakehashi, A; Miki, Y; Murai, K; Nota, T; Ogawa, S; Sohgawa, E; Yamamoto, A; Yonezawa, H, 2023) |
| "The purpose of this study was to investigate the effect of combined therapy of diacerein and gold nanoparticles (AuNP) on diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in a rat model." | 4.31 | Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study. ( Baokbah, TAS, 2023) |
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 4.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "This study was designed to evaluate the potential protective impact of estrogen and estrogen receptor against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 4.31 | Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis. ( Abdel-Hamid, MS; Abdelhady, R; El-Sayed, EM; Elsadek, BEM; Hassan, MH; Mansour, AM; Salama, SA, 2023) |
| " O-GlcNAc transferase-KO mice exacerbated diethylnitrosamine-induced HCC development with increased inflammation, fibrosis, and YAP signaling." | 4.31 | The essential role of O-GlcNAcylation in hepatic differentiation. ( Apte, U; Hanover, JA; Kotulkar, M; Paine-Cabrera, D; Robarts, DR; Slawson, C; Venneman, KK; Zachara, NE, 2023) |
| " Further we emphasize to study the role of CPT against hepatocellular carcinoma (HCC) induced by N-diethylnitrosamine (DEN) in male swiss albino mice in vivo." | 4.12 | Potential anticancer effects of cyclo(-Pro-Tyr) against N-diethyl nitrosamine induced hepatocellular carcinoma in mouse through PI3K/AKT signaling. ( Arumugam, MK; Karanam, G, 2022) |
| "Our results show that the expression of mRNA of IQGAP1, TRAIL decoy receptors, NF-κB, and IL-8 genes was elevated in hepatocellular carcinoma, as compared to normal liver tissue, while their expression was further up-regulated by increasing the dose of diethylnitrosamine." | 4.12 | New Approach about the Signaling Crosstalk between IQGAPs/ NF- κB/IL-8 and PDCD5/p53/TRAIL Pathways that Modulate Malignant Transformation in Hepatocellular Carcinoma. ( Abdelhafez, MA; Darwish, AM; Mahrous, KF; Zoheir, KMA, 2022) |
| "Swiss Albino (BALB/c) mice of around 10-12 weeks old were exposed to a known hepatocarcinogen-diethylnitrosamine at a dose of 20 mg/kg body weight at weekly intervals for a period of 4, 8, 12, & 16 weeks." | 4.12 | Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma. ( Kma, L; Priya, S, 2022) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 4.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| "Hepatocellular carcinoma was induced in 40 rats with diethylnitrosamine." | 4.12 | Therapeutic Role of Bone Marrow-Derived Mesenchymal Stem Cells in Controlling Prognosis of Hepatocellular Carcinoma in a Murine Model. ( Abd El Fattah El Sayed, H; Atta, S; Elzayat, E; Hussein, T; Kamel, M; Mahmood, D; Mansour, W; Saber, S, 2022) |
| " Take advantage of the combinatory treatment with a single dose of diethylnitrosamine (DEN) and chronic feeding with high-fat diet (HFD), we demonstrated that hepatic depdc5 deletion did not aggravate DEN&HFD induced liver tumorigenesis, probably due to its protective effects on diet-induced liver steatosis." | 4.02 | Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice. ( Huang, R; Li, Z; Ma, H; Ma, J; Wang, J; Wang, Q; Xiong, X; Xu, L; Yang, C, 2021) |
| "Recently, our group showed that Romidepsin, a histone deacetylase inhibitor (HDACi), suppressed diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in mice." | 4.02 | Romidepsin hepatocellular carcinoma suppression in mice is associated with deregulated gene expression of bone morphogenetic protein and Notch signaling pathway components. ( Afaloniati, H; Angelopoulou, K; Gargavanis, A; Giakoustidis, A; Giakoustidis, D; Poutahidis, T, 2021) |
| " Here, hyperpolyploidization of hepatocytes around the centrilobular (CL) region is demonstrated to be closely linked with the development of HCC cells after diethylnitrosamine treatment." | 4.02 | Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver. ( Chao, HW; Chen, H; Chen, HW; Doi, M; Fustin, JM; Hou, HS; Huang, YS; King, PC; Lai, HH; Lee, YL; Lin, H; Lin, SH; Young, PY, 2021) |
| " In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis." | 4.02 | Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks. ( Campbell, MJ; Clinton, SK; Coss, CC; Getaneh, S; Helms, TH; Kulp, SK; LeMoine, DM; Lucas, F; Mullins, RD; Phelps, MA; Schmidt, N; Thomas-Ahner, JM; Xie, Z, 2021) |
| " nigra extract (MNE) on diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC)." | 4.02 | Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma. ( Ghorbani, A; Hasanpour, M; Hooshmand, S; Iranshahi, M; Mahdinezhad, MR; Mirzavi, F; Soukhtanloo, M; Taraz Jamshidi, S, 2021) |
| "This study aimed to evaluate the cancer chemopreventive activity of vanillic acid (VA) in diethylnitrosamine- and 1,2-dimethylhydrazine-induced liver and colon carcinogenesis in rats." | 4.02 | Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats. ( Chariyakornkul, A; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2021) |
| " Here, we investigated the effects of maternal diets differing in protein source on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in adult rat offspring." | 3.96 | Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring. ( Choi, J; Kwon, YH; Won, SB, 2020) |
| " The present study investigates the anticancer activity of ligand-L and its mode of action in rat model of diethylnitrosamine (DEN) induced hepatocellular carcinoma." | 3.96 | Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma. ( Khan, S; Naseem, I; Zafar, A, 2020) |
| "This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment." | 3.96 | Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020) |
| " Nimbolide is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties; however, its anticancer effects and molecular mechanism in hepatocellular carcinoma (HCC) remains obscure." | 3.96 | Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis. ( Ram, AK; Srinivas, BH; Vairappan, B, 2020) |
| " In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanoparticles (GaNPs) combined with low level of gamma radiation (IR), on the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 3.91 | Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats. ( El-Sonbaty, SM; Mansour, SZ; Moawed, FS, 2019) |
| "Mito-TEMPO was effective in combating hepatocarcinogenesis." | 3.91 | Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. ( Bharati, S; Kumar, R; Shetty, S, 2019) |
| " Diethylnitrosamine (DEN) is one of the recognized risk factors for hepatocarcinogenesis likely due to CYP2E1-mediated metabolic activation." | 3.88 | Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine. ( Chang, Z; Fang, Y; Gao, J; Gao, N; Jin, H; Qiao, HL; Wang, CE; Wang, GJ; Wang, J; Wang, Z; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| " We studied mice with bile-duct ligation, orthotopic cholangiocarcinomas, cholestasis-induced cholangiocarcinoma, diethylnitrosamine-induced liver tumors, and xenograft tumors." | 3.88 | Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. ( Annamalai, A; Fan, W; Li, TWH; Liu, T; Liu, Z; Lu, SC; Maldonado, SS; Mato, JM; Noureddin, M; Seki, E; Shen, H; Steggerda, J; Tu, J; Wang, J; Xiong, T; Yang, H; Yang, J, 2018) |
| "Hepatocellular carcinoma (HCC) was induced in male Wistar rats by the administration of diethylnitrosamine (DEN) during 16 weeks." | 3.88 | Resistive Part of Impedance as a Possible Indicator of Hepatocellular Carcinoma. ( Camacho, J; Chávez-López, MG; Elías-Viñas, D; Salazar-Anguiano, J; Zúñiga-García, V, 2018) |
| "encapsulated GA-NC (gallic acid nanocomposite) in normal and hepatocellular carcinoma (HCC)-induced rats." | 3.88 | Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation ( Abd-Rabou, AA; Ahmed, HH; Galal, AF; Mehaya, FM; Shalby, AB, 2018) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 3.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| "Rationale of this study was framed to investigate the protective effect and anti-cancer property of nanoparticles based on chitosan isolated from squid, Sepioteuthis lessoniana, on hepatic cells in N-Nitrosodiethylamine-induced hepatocellular carcinoma in rats." | 3.85 | Chitosan nanoparticles from marine squid protect liver cells against N-diethylnitrosoamine-induced hepatocellular carcinoma. ( Shanmugam, A; Shanmugam, V; Subhapradha, N, 2017) |
| " Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which are the major molecules to be responsible for transducing insulin/IGF signaling in the liver, in the development of HCC by inducing chemical carcinogenesis using diethylnitrosamine (DEN) in mice." | 3.85 | Role of insulin receptor substrates in the progression of hepatocellular carcinoma. ( Aihara, M; Hayashi, T; Iwamoto, M; Kadowaki, T; Kubota, N; Kubota, T; Nishihara, H; Obata, A; Sakurai, Y; Takamoto, I, 2017) |
| "This study aimed to evaluate the antitumor activity of platinum nanoparticles compared with cis-platin both in vitro and in vivo in the treatment of hepatocellular carcinoma induced in rats." | 3.85 | Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats. ( El-Sonbaty, S; Kandil, E; Mahmoud, M; Mansour, S; Medhat, A, 2017) |
| " Hepatocellular Carcinoma (HCC) was induced in the liver of male Sprague Dawley (SD) rats by treating with diethylnitrosamine (DEN)." | 3.85 | In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model. ( Antony Joseph, SR; Krishnan, GS; Rajagopal, V; Savarimuthu, I; Sebastian, D; Selvaraj, KRN; Thobias, AF, 2017) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 3.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 3.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| " Treatment with 2500 ppm ACI for 26 weeks after initiation with diethylnitrosamine increased the incidence and multiplicities of altered foci and adenomas in hepatocytes from WT mice; these effects were significantly reduced in CARKO mice." | 3.83 | Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. ( Ichimura, R; Inoue, K; Kodama, Y; Kuwata, K; Shibutani, M; Takahashi, M; Yoshida, M, 2016) |
| "The aim of this study is to understand the molecular mechanisms of N-nitrosodiethylamine (NDEA) induced multi-organ carcinogenesis in tongue and liver of the same mouse and restriction of carcinogenesis by Epigallocatechin gallate (EGCG) and Theaflavin (TF), if any." | 3.83 | Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice. ( Barua, A; Pal, D; Panda, CK; Roy, A; Roy, R; Saha, P; Sur, S, 2016) |
| " Using the diethylnitrosamine-induced hepatocarcinogenesis model, 2-Formyl-8-hydroxy-quinolinium chloride showed strong antiangiogenic activity." | 3.83 | Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride. ( Bian, ZX; Chan, KW; Chan, RY; Cheng, CH; Cheng, GY; Chui, CH; Gambari, R; Hau, DK; Kok, SH; Lam, KH; Lau, FY; Lee, KK; Tang, JC; Tong, SW; Wong, RS; Wong, WY, 2016) |
| " The aim of this study was to evaluate the anti-tumor effect of Celastrol against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats and furthermore, to explore the underlying mechanism." | 3.83 | Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. ( Chang, W; He, W; Li, PP; Lu, JT; Song, SS; Wei, W; Yuan, PF, 2016) |
| " The present investigation was carried out to evaluate antioxidant status and lipid peroxidation level of anticancer activity of Solanum xanthocarpum (SXC) on Diethylnitrosamine (DEN) induced hepato carcinogenesis in male Wistar albino rats." | 3.83 | Evaluation of antioxidant and stabilizing lipid peroxidation nature of Solanum xanthocarpum leaves in experimentally diethylnitrosamine induced hepatocellular carcinogenesis. ( Indumathi, D; Iyappan, P; Velu, P; Vijayalakshmi, A, 2016) |
| " Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity." | 3.81 | Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Shimizu, M; Shirakami, Y; Tanaka, T; Tsurumi, H, 2015) |
| "In this study, we explored whether treatment with FGF-21 could prevent diethylnitrosamine (DEN) induced hepatocarcinogenesis in mice." | 3.81 | Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice. ( Li, D; Liu, M; Liu, Z; Rasoul, LM; Ren, G; Wang, W; Wu, Q; Xu, P; Ye, X; Yuan, Q; Zhang, Y, 2015) |
| " To further confirm our hypothesis in vivo, we induced hepatocellular carcinoma (HCC) in rats by diethylnitrosamine (DEN)." | 3.81 | Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate. ( Ahmad, A; Farhan, M; Hadi, SM; Naseem, I; Rizvi, A, 2015) |
| " Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals." | 3.81 | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging. ( Fujisawa, K; Furutani-Seiki, M; Matsumoto, T; Nishina, H; Sakaida, I; Takami, T; Terai, S; Yamamoto, N, 2015) |
| " The present study was envisaged to investigate the possible synergistic effect of combined treatment of curcumin with piperine in suppression of diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats, owing to permeability enhancing effect of latter." | 3.81 | Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. ( Padwad, YS; Patial, V; Pratap, K; S, M; Sharma, S; Singh, D, 2015) |
| " The aim of this study was to investigate molecular mechanisms for the chemopreventive effects of folic acid and tributyrin alone or in combination on rat hepatocarcinogenesis." | 3.80 | Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. ( Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V, 2014) |
| " In this study, we characterized cell signaling events evoked by decorin deficiency in two experimental models of hepatocarcinogenesis using thioacetamide or diethyl nitrosamine as carcinogens." | 3.80 | Decorin deficiency promotes hepatic carcinogenesis. ( Baghy, K; Fullár, A; Horváth, Z; Iozzo, RV; Kiss, K; Kovalszky, I; Schaff, Z, 2014) |
| "We investigated the possible therapeutic effect of irreversible proteasome inhibitor, carfilzomib against hepatocellular carcinoma induced chemically by chronic administration of diethylnitrosoamines (DENA)." | 3.80 | Possible role of selective, irreversible, proteasome inhibitor (carfilzomib) in the treatment of rat hepatocellular carcinoma. ( Al-Hosaini, K; Al-Rikabi, AC; Aljoufi, MA; Mansour, MA; Nagi, MN, 2014) |
| "The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model." | 3.80 | Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats. ( Geng, CZ; Liu, YP; Peng, L; Wang, SJ; Wang, X; Yang, HC; Zhao, JA, 2014) |
| "The possible molecular mechanisms of Nano-selenium (nano-se) in attenuating hepatocellular carcinoma (HCC) was investigated in this study." | 3.80 | Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats. ( Ahmed, HH; Hamza, AH; Khalil, WK, 2014) |
| " In the present study we found that DPAA significantly enhanced the development of diethylnitrosamine-induced preneoplastic lesions in the liver in a medium-term rat liver carcinogenesis assay." | 3.79 | Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. ( Fujioka, M; Kakehashi, A; Kato, M; Kitano, M; Tago, Y; Wanibuchi, H; Wei, M; Yamada, T; Yamano, S, 2013) |
| " In this study, we found that diethylnitrosamine initiation with CCl4 and ethanol promotion could induce a short-term, two-stage liver carcinogenesis model in male BALB/c mice, the process of hepatocarcinogenesis including liver damage, liver necrosis/cell death, liver inflammation, liver proliferation, liver hyperplasia, liver steatosis, and liver cirrhosis and hepatocellular nodules, which mimicked the usual sequence of events observed in human HCC." | 3.79 | Two-stage model of chemically induced hepatocellular carcinoma in mouse. ( Huang, SX; Kuang, ZP; Li, YD; Luo, M; Luo, XL; Wu, JN; Xie, YA; Yang, F, 2013) |
| " We recently find that the loss of toll-like receptor 2 (TLR2) activities promotes the diethylnitrosamine (DEN) induced hepatocellular carcinogenesis and tumor progression, which associates with an abundant accumulation of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress." | 3.79 | Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. ( Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ, 2013) |
| " To explore the role of CHOP in hepatocarcinogenesis, we induced hepatocellular carcinoma (HCC) in wild type (wt) and CHOP knockout (KO) mice using the carcinogen N-diethylnitrosamine (DEN)." | 3.79 | CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. ( Chung, RT; Mueller, T; Nahmias, A; Scaiewicz, V; Shibolet, O; Tirosh, B, 2013) |
| " The aim of this study was to investigate the inhibitory effect of a glycoprotein (38 kDa) isolated from Styrax japonica Siebold et al Zuccarini (SJSZ) on metastasis of hepatocellular carcinoma (HCC) in diethylnitrosamine (DEN)-treated imprinting control region (ICR) mice." | 3.78 | Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice. ( Lee, J; Lim, KT, 2012) |
| "Diethylnitrosamine (DEN) is a hepatic procarcinogen which is frequently used as an inducer of hepatocellular carcinoma (HCC) in mice." | 3.77 | Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice. ( Aleksic, K; Auer, M; Fischer, M; Geigl, JB; Lackner, C; Otte, M; Schwarz, M; Speicher, MR; Trajanoski, Z; Ulz, P, 2011) |
| " Furthermore, Shp2 ablation dramatically enhanced diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) development, which was abolished by concurrent deletion of Shp2 and Stat3 in hepatocytes." | 3.77 | Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. ( Bailly-Maitre, B; Bard-Chapeau, EA; Ding, J; Fang, DD; Feng, GS; Han, T; Li, S; Poli, V; Princen, F; Varki, NM; Wang, H; Zhang, SS; Zhu, HH, 2011) |
| " In the present study, we showed that MAP1S levels immediately become elevated in response to diethylnitrosamine-induced or genome instability-driven metabolic stress in a murine model of hepatocarcinoma." | 3.77 | Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis. ( Liu, L; McKeehan, WL; Wang, F; Xie, R, 2011) |
| "Modified Diethylnitrosamine (DEN)-induced primary hepatocellular carcinoma rat model was established." | 3.75 | [The expression of B-cell translocation gene 2 in diethylnitrosamine-induced primary hepatocellular carcinoma rat model.]. ( Chen, C; Jin, F; Li, Q; Li, ZP; Luo, XZ; Shan, JL; Wang, D; Wang, G; Xu, W; Yang, ZX; Zhang, ZM, 2009) |
| " To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma." | 3.75 | Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009) |
| " We induced hepatocellular carcinomas (HCCs) in rats with N-nitrosodiethylamine (DEN) and a choline-deficient l-amino acid-defined (CDAA) diet." | 3.74 | Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats. ( Honoki, K; Mori, C; Nishikawa, T; Onishi, M; Sokuza, Y; Tsujiuchi, T; Uwataki, K, 2007) |
| "Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear." | 3.74 | Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008) |
| " Growth of hepatocellular carcinoma (HCC), developed by a single injection of diethylnitrosamine (DEN), was the same in both the TIS21(+/+) and TIS21(-/-) mice until 6 months, whereas it was significantly higher in the TIS21(-/-) mice at 9 months." | 3.74 | TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop. ( Kang, SY; Kim, BW; Kim, HC; Kim, JY; Lim, IK; Oh, SP; Park, TJ; Song, KY; Wang, HJ, 2008) |
| "Taken together, these findings identify a mechanism of ABT-100 function and show the efficacy of ABT-100 as a chemopreventive agent of hepatocellular carcinoma." | 3.73 | Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent. ( Carloni, V; Pantaleo, P; Vizzutti, F, 2005) |
| " Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) increases the drug efficacy on HCCs induced in rats by diethylnitrosamine (DENA)." | 3.73 | Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine. ( Bolondi, L; Busi, C; Chieco, P; Di Stefano, G; Fiume, L; Kratz, F; Lanza, M; Mattioli, A, 2005) |
| " However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and efficacy of hydrodynamic injection via the tail vein and hepatic artery in a diethylnitrosamine (DEN)-induced HCC model in rats." | 3.73 | High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine. ( Hatano, E; Ikai, I; Koizumi, N; Nitta, T; Shimahara, Y; Tada, M; Taura, K, 2006) |
| ") injection of 200 mg/kg body weight diethylnitrosamine (DEN)." | 3.73 | Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Dhachinamoorthi, D; Panayappan, L; Srivastawa, S, 2006) |
| "Hepatocellular carcinoma (HCC) was induced by diethylnitrosamine in 70 treated rats with 20 normal rats used as controls." | 3.73 | In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model. ( Li, X; Xie, JX; Xu, H; Yang, ZH, 2006) |
| " Glutathione S-transferase placental (GST-P)-negative hepatocellular altered foci (HAF), hepatocellular adenoma (HCA), and hepatocellular carcinoma (HCC) were generated by two initiation-promotion models with N-nitrosodiethylamine (NDEN) and peroxisome proliferators, Wy-14,643 and clofibrate." | 3.72 | alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. ( Fukushima, S; Kikuchi, K; Kushida, M; Mikami, N; Morimura, K; Oeda, K; Okuno, Y; Ozaki, K; Saito, K; Sukata, T; Sumida, K; Uwagawa, S, 2004) |
| ") injection of diethylnitrosamine (DEN) (125 mg kg(-1) body weight) at week 4 followed by promotion with streptozotocin (STZ) (65 mg kg(-1) body weight with a single i." | 3.71 | 1alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes and the development of gamma-glutamyltranspeptidase-positive foci in diethylnitrosamine-initiated and streptozotocin-induced diabetes-promoted hepatocarcinogenesis. ( Bhattacharya, R; Chatterjee, M; Saha, BK, 2002) |
| " After application of diethylnitrosamine (DEN) preneoplastic foci and adenomas emerged in liver tissue of wild-type and phosphoenolpyruvate carboxykinase (PEPCK)-IGF-II transgenic mice." | 3.71 | Diethylnitrosamine induces long-lasting re-expression of insulin-like growth factor II during early stages of liver carcinogenesis in mice. ( Deml, E; Gittner, K; Hoeflich, A; Krebs, O; Lahm, H; Oesterle, D; Sprague, L; Wanke, R; Wolf, E, 2002) |
| "The effect of nodularin on selective atrophy of left lobes in the liver was investigated in F344 rats." | 3.71 | Selective left-lobe atrophy by nodularin treatment accompanied by reduced protein phosphatase 1/2A and increased peroxisome proliferation in rat liver. ( Choi, YK; Hyun, BH; Kwak, CS; Le, MS; Lim, IK; Park, SC; Park, TJ; Song, KY; Yoon, G, 2001) |
| "To elucidate involvement of the transforming growth factor-beta (TGF-beta) signaling pathway in endogenous and exogenous liver carcinogenesis, we investigated mutations of TGF-beta receptor type II (TGF-betaRII), Smad2 and Smad4 genes, and expression of TGF-betaRII in hepatocellular carcinomas (HCCs) induced by a choline-deficient L-amino acid-defined (CDAA) diet and by N-nitrosodiethylamine (DEN)." | 3.71 | Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats. ( Konishi, Y; Murata, N; Sasaki, Y; Tsujiuchi, T; Tsutsumi, M, 2001) |
| "GABAergic alterations in hypothalamus during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN) induced direct hyperplasia and N-nitrosodiethylamine (NDEA) induced neoplasia in liver were investigated." | 3.71 | Hypothalamic GABA receptor functional regulation and liver cell proliferation. ( Biju, MP; Paulose, CS; Pyroja, S; Rajeshkumar, NV, 2001) |
| "We previously found by chance that N-nitrosomorpholine (NMOR) given after a multi-carcinogenic treatment induces liver carcinomas with 56% lung metastasis, and it was confirmed that hepatocellular carcinoma (HCC) with 100% lung metastasis was produced by 24-week treatment with NMOR and additional treatment with diethylnitrosamine (DEN)." | 3.70 | Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model. ( Futakuchi, M; Hirose, M; Kato, K; Ogawa, K; Ogiso, T; Sano, M; Shirai, T, 1999) |
| "We established a cell line (MHB-2) from a hepatoblastoma (HB) induced by diethylnitrosamine (DEN) and sodium phenobarbital (PB) in male B6C3F1 mice and examined the biological characteristics of MHB-2." | 3.70 | Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma. ( Goto, K; Kobayashi, K; Mutai, M; Sakairi, T; Sugimoto, J; Tsuchiya, T, 2000) |
| " In this study we report that gavage administration of 200 mg/kg or 600 mg/kg CCM effectively suppressed diethylnitrosamine (DEN)-induced liver inflammation and hyperplasia in rats, as evidenced by histopathological examination." | 3.70 | Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. ( Cheng, AL; Chuang, SE; Kuo, ML; Lin, JK, 2000) |
| "A CK immunohistochemical study was carried out on histologic sections from hepatocellular carcinomas (HCCs) and preneoplastic lesions from 118 monkeys chronically dosed with diethylnitrosamine (DEN), using mAbs to CK 8, CK 18, CK 7, and CK 19." | 3.69 | Cytokeratin patterns of liver carcinomas induced by diethylnitrosamine in monkeys. ( Bocsi, J; Lapis, K; Sarosi, I; Thorgeirsson, UP, 1995) |
| " A total of 230 males were initially injected with diethylnitrosamine (200 mg/kg body weight, ip) or saline as controls and 2 wk later were fed on diet or drinking water supplemented as follows for 6 wk: 5% regular instant coffee; 5% decaffeinated instant coffee; freshly brewed coffee, 8 g in 140 ml water; 0." | 3.69 | Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. ( Hasegawa, R; Imaida, K; Ito, N; Ogiso, T; Shirai, T, 1995) |
| "To determine whether a constitutive p53 deficiency would enhance the rate of development of chemically induced hepatocellular carcinoma, we treated groups of wild-type, p53-heterozygous (+/-), and null (-/-) male mice with a single dose of diethylnitrosamine at 12 d of age." | 3.69 | Hepatocarcinogenesis in p53-deficient mice. ( Kemp, CJ, 1995) |
| " Metallothionein (MT), an inducible metal-binding protein associated with tolerance to many metal including Cd, was not detected immunohistochemically in mouse liver tumors, even those undergoing Cd-induced necrosis, whereas the surrounding normal liver cells expressed high levels of MT after Cd exposure." | 3.69 | Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice. ( Cherian, MG; Diwan, BA; Goyer, RA; Moussa, M; Rehm, S; Waalkes, MP; Ward, JM, 1996) |
| "Two-stage carcinogenesis of mouse skin papillomas induced by 7,12-dimethylbenz[alpha]anthracene and 12-O-tetradecanoylphorbol 13-acetate, and mouse hepatic tumors induced by N-nitrosodiethylamine and phenobarbital, were inhibited by lantadenes." | 3.69 | Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors. ( Inada, A; Nakanishi, T; Nishino, H; Sharma, OP; Tokuda, H, 1997) |
| "Formation and repair of O6-medG and N7-medG (O6- and N7-methyldeoxyguanosine) in glutathione S-transferase-P form (GST-P)-positive liver cell foci, nodules, primary hepatocellular carcinoma (HCC) and transplanted hepatocellular carcinoma (TRP) induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) were immunohistochemically assessed following a single exposure to dimethylnitrosamine (DMN)." | 3.68 | Decreased dimethylnitrosamine-induced O6- and N7-methyldeoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis. ( Asamoto, M; Iwase, T; Kato, T; Matsumoto, K; Montesano, R; Nagao, S; Ozaki, K; Tsuda, H; Wild, CP, 1993) |
| "Exposure of female hepatitis B virus transgenic mice of lineage 50-4, which display liver injury secondary to overexpression of the gene for the large envelope polypeptide of hepatitis B virus, to the hepatocarcinogens aflatoxin and diethylnitrosamine produced more rapid and extensive evidence of nodule formation and oval cell proliferation, as well as the development of adenomas and primary hepatocellular carcinomas, than was seen in transgenic mice not exposed to carcinogens." | 3.68 | Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. ( Chisari, FV; Dunsford, HA; Hunt, JM; Sell, S, 1991) |
| " Liver carcinogenesis was initiated by intraperitoneal injection of diethylnitrosamine (DEN) in male B6C3F1 mice at 100 or 200 mumol/kg body weight once a week for 10 weeks (total exposure 1000 or 2000 mumol/kg body weight)." | 3.68 | Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis. ( Iatropoulos, MJ; Tokumo, K; Williams, GM, 1991) |
| " Animals were given a single dose of diethylnitrosamine (100 mg/kg body weight)." | 3.68 | Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci. ( Chelo, A; Columbano, A; Curto, M; Ennas, MG; Ledda-Columbano, GM; Pani, P, 1990) |
| "The histologic and ultrastructural features of hepatic hemangiopericytoma from a medaka (Oryzias latipes) exposed for 48 hr to 400 mg/liter of diethylnitrosamine at 14 days of age are described." | 3.68 | Ultrastructure of hepatic hemangiopericytoma in the medaka (Oryzias latipes). ( Bunton, TE, 1991) |
| "Cell nuclear DNA ploidy patterns were examined using cytofluorometry in hepatocellular carcinomas (HCC) induced by diethylnitrosamine (DEN) in rat and human HCC." | 3.67 | [Biological activity of hepatocellular carcinoma by analysing nuclear DNA ploidy patterns and using anti BrdU monoclonal antibody]. ( Jung-Rou, T, 1989) |
| "The effects of the chronic administration of methyl-deficient, amino acid-defined diets on liver tumor formation were examined in male weanling C3H/HeN mice previously treated with a single ip injection of 0 or 150 mg diethylnitrosamine/kg body weight [(DENA) CAS: 55-18-5]." | 3.67 | Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets. ( Creasia, D; Hoover, KL; Mikol, YB; Poirier, LA; Shivapurkar, N; Wilson, MJ, 1986) |
| "The aim of this study was to determine whether a dietary restriction, which significantly decreases body weight gain, also influences the development of diethylnitrosamine (DEN)-induced liver tumours in Swiss mice." | 3.67 | The influence of food intake on the development of diethylnitrosamine-induced liver tumours in mice. ( Lagopoulos, L; Stalder, R, 1987) |
| " The animal models were Sewall Wright strain 13 guinea pigs with 3-methyl-cholanthrene (MCA)-induced fibrosarcomas and strain 2 guinea pigs with diethylnitrosamine (DEN)-induced hepatocarcinomas." | 3.66 | Guinea pig cell-mediated tumor immunity: the chromium release assay detects both cytolysis and serum blocking for syngeneic chemically-induced tumors. ( Blazkovec, AA; Miller, FR, 1979) |
| "2% N-ethyl-N-hydroxyethylnitrosamine (EHEN) for 2 weeks induced hepatocellular carcinoma in 3 and renal tubular cell tumors in 7 of 9 Wistar rats." | 3.66 | Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine. ( Hiasa, Y; Iwata, C; Ohshima, M; Tanikake, T, 1979) |
| "05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
| "Administration of 40 ppm diethylnitrosamine (DENA) in the drinking water for 10 weeks to male Fischer rats led to hepatocellular carcinoma in 100 percent with metastasis to the lung in 40 percent, of the animals living for the full experimental period of 20 weeks." | 3.65 | Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression. ( Madison, RM; Viguera, C; Ward, JM; Weisburger, EK; Weisburger, JH, 1975) |
| "The characteristic clostridial growth which is testable, after systemic administration of tetanus spores, as a positive tumour tetanus - correlation, was manifested by a highly selective tetanus lethality of rats with progressive hepatomas following induction with dimethylaminoazobenzene and diethylnitrosamine, respectively, as well as with methylcholanthren-induced fibrosarcomas of the rat." | 3.65 | [The tumor-tetanus assay--experimental studies on the biological differentiation between carcinogenesis and organ regeneration of the rat (author's transl)]. ( Fabricius, EA; Schneeweiss, U, 1975) |
| "Liver neoplasms were induced in medakas (Oryzias latipes) by the addition of diethylnitrosamine (DENA) to their aquarium water at levels of 15-135 ppm for 8 weeks." | 3.65 | Histologic and electron microscopy observations on diethylnitrosamine-induced hepatomas in small aquarium fish (Oryzias latipes). ( Ishikawa, T; Shimamine, T; Takayama, S, 1975) |
| "The frequency of metastases of malignant diethylnitrosamine-induced hepatomas and haemangioendotheliomas of the liver of female Sprague-Dawley rats (29%) was not influenced by application of acetyl-salicylic acid or phenprocoumon." | 3.65 | [Studies on the influence of anticoagulants on metastase formation of autochthonic hepatomas in the rat (author's transl)]. ( Schmähl, D, 1975) |
| "The effects of treatments with diethylnitrosamine (DENA) and hepatitis B virus (HBV) on macaque monkeys were investigated by virus serology and by light and electron microscopy." | 3.65 | Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus. ( Cabral, GA; Gyorkey, F; Gyorkey, P; Hollinger, FB; Melnick, JL; Mirkovic, R, 1977) |
| "In fact, liver cancer often develops in the context of chronic liver injury." | 2.53 | Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. ( Dhar, D; Karin, M, 2016) |
| "Hepatocellular carcinoma is the second most cause of death among the various cancers worldwide." | 1.91 | Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats. ( Amudha, P; Jayalakshmi, M; Poojitha, BN; Vidya, R, 2023) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 1.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| " However, its therapeutic activity is limited by poor bioavailability and unpredictable distribution." | 1.91 | Lactosylated Chitosan Nanoparticles Potentiate the Anticancer Effects of Telmisartan In Vitro and in a ( El-Gizawy, SA; Essa, EA; Kira, AY; Nasr, M; Saber, S, 2023) |
| "In the present study, hepatocellular cancer (HCC) induced by diethylnitrosamine (DEN) in rats and then treated with the new chromene derivative and the parameters TNF-α, VEGF, p53, Cyt C, MMP-9, Bcl2, and Bax were measured." | 1.72 | In vivo Study of a Newly Synthesized Chromen-4-one Derivative as an Antitumor Agent against HCC. ( El-Mezayen, HA; Mahdy, EME; Mansour, SZ; Mohamed, SA; Nabeel, AI, 2022) |
| "Alcohol is a well-known risk factor for hepatocellular carcinoma." | 1.72 | Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis. ( Ballabio, A; Chao, X; Ding, WX; Hlobik, M; Ni, HM; Wang, S, 2022) |
| "Prunetin (PRU) is an O-methylated flavonoid that is present in various natural plants and a primary significant compound found in isoflavone." | 1.72 | Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats. ( Chen, H; Li, G; Qi, L; Tian, G, 2022) |
| "The arbutin treatment effectively improved body weight and reduced liver weight in animals with DEN-provoked liver cancer." | 1.72 | Anticancer Effect of Arbutin on Diethylnitrosamine-Induced Liver Carcinoma in Rats via the GRP and GADD Pathway. ( Chen, X; Dong, P; Huang, Z; Liu, H; Zeng, X, 2022) |
| "gigantea stem bark extracts in liver cancer HepG2 cells and diethylnitrosamine (DEN)-induced primary liver cancer in rats." | 1.72 | Calotropis gigantea stem bark extracts inhibit liver cancer induced by diethylnitrosamine. ( Intapa, C; Kaewkong, W; Parhira, S; Pekthong, D; Sawong, S; Somran, J; Srisawang, P; Suknoppakit, P; Winitchaikul, T, 2022) |
| "Boron has great potential to reduce the effects of oxidative stress, which may help it inhibit the progression of HCC." | 1.72 | Boron attenuated diethylnitrosamine induced hepatocellular carcinoma in C3H/HeN mice via alteration of oxidative stress and apoptotic pathway. ( Chen, J; Huang, H; Wang, J; Wei, Y; Wu, L; Yi, JK; Yin, X, 2022) |
| "BALB/c mice model of hepatocarcinogenesis was established using N-nitrosodiethylamine as a carcinogen (200 mg/kg b." | 1.72 | MitoQ demonstrates connexin- and p53-mediated cancer chemoprevention in N-nitrosodiethylamine-induced hepatocarcinogenesis rodent model. ( Bharati, S; De, S; Qsee, HS; Tambe, PK, 2022) |
| "Diethylnitrosamine-induced hepatocellular carcinomas were then investigated in lean and diet-induced obese miR-22-deficient mice." | 1.72 | MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver. ( Ay, AS; Correia de Sousa, M; Delangre, E; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Sempoux, C; Sobolewski, C, 2022) |
| "Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality." | 1.62 | Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma. ( Balaraman, G; Krishnan, P; Mari, A; Salam, S; Sirajduddin, I; Subramaniam, N; Sundaram, J; Thiruvengadam, D, 2021) |
| " The study aimed to investigate the pharmacokinetic mechanism of herb-drug interactions between ADI and DOX in a rat model of HCC." | 1.62 | Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma. ( Cao, C; Chen, S; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zhang, S; Zhu, X, 2021) |
| " As a competitor of SHBG-androgen binding, EE2 could bind with SHBG and increase the bioavailability of androgen." | 1.62 | Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin. ( Heo, JH; Hong, EJ; Jeong, SH; Jo, SL; Ko, JW; Kwun, HJ; Lee, SR, 2021) |
| "TREM-2 plays a protective role in hepatocarcinogenesis via different pleiotropic effects, suggesting that TREM-2 agonism should be investigated as it might beneficially impact HCC pathogenesis in a multifactorial manner." | 1.62 | TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. ( Agirre-Lizaso, A; Andersen, JB; Aspichueta, P; Azkargorta, M; Banales, JM; Bujanda, L; Elortza, F; Esparza-Baquer, A; Hijona, E; Jimenez-Agüero, R; Knapp, S; La Casta, A; Labiano, I; Landa, A; Mann, DA; Munoz-Garrido, P; O'Rourke, CJ; Oakley, F; Perugorria, MJ; Riaño, I; Rodrigues, PM; Schabbauer, G; Sharif, O; Vogel, A; Zaki, MYW; Zhuravleva, E, 2021) |
| "The role of TTP in nonalcoholic steatohepatitis and HCC development was further examined through in vivo/vitro approaches using liver-specific TTP knockout mice and a panel of hepatic cancer cells." | 1.62 | Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. ( Bejuy, O; Berthou, F; Blackshear, PJ; Colin, DJ; Correia de Sousa, M; De Vito, C; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Rubbia-Brandt, L; Sobolewski, C, 2021) |
| "Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide." | 1.62 | Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis. ( Fares, NH; Mahmoud, AA; Mahmoud, YI; Shehata, AMM, 2021) |
| "The remaining 10 rats were the liver cancer model group and treated with diethylnitrosamine (DEN) to induce liver cancer." | 1.62 | Correlation between inflammatory cytokines and liver cancer stem cell markers in DEN-induced liver cancer rats. ( Bai, MJ; Bu, JG; Chen, CY; Li, JQ; Liu, ZH; Yan, SH; Ye, XW, 2021) |
| "The DEN-challenged liver cancer in experimental rats caused increased liver weight, 8-OHD, hepatic tissue injury marker, lipid peroxidation, and tumor markers levels." | 1.62 | Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells. ( Alahmadi, TA; Chinnathambi, A; Li, Z; Lu, B; Xie, Y; You, Y; Zhang, L; Zhu, F, 2021) |
| " In the present study, mitochondria targeted antioxidant, mito-TEMPO was administered to male BALB/c mice at a dosage 0." | 1.62 | Mitochondria-targeted antioxidant, mito-TEMPO mitigates initiation phase of N-Nitrosodiethylamine-induced hepatocarcinogenesis. ( Anushree, U; Bharati, S; Kumar, R; Shetty, S, 2021) |
| "Hepatocellular carcinoma in nonalcoholic steatohepatitis is caused by the complex factors of inflammation, fibrosis and microbiomes." | 1.62 | Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine. ( Fujishiro, M; Honda, T; Ishigami, M; Ishizu, Y; Ito, T; Kato, A; Kawashima, H; Kuzuya, T; Ma, L; Nakamura, M; Tsuji, NM; Yamamoto, K; Yokoyama, S, 2021) |
| "In in vitro and in vivo hepatocellular carcinoma mouse models it can significantly suppress primary tumor growth, prevent distant metastasis/cell migration, reduce angiogenesis, and normalize the immunosuppressive tumor microenvironment by reducing tumor-associated macrophages (TAMs) infiltration, reprogramming TAMs toward an immunostimulatory phenotype and promoting cytotoxic T cell infiltration into tumor." | 1.62 | A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment. ( Chang, CC; Chen, Y; Chou, MC; Dinh, TK; Huang, JK; Huang, KW; Jan, JJ; Ke, YY; Lee, CJ; Shia, KS; Shiue, TY; Song, JS; Sung, YC; Ta, YN; Wu, CH; Yeh, KC; Yeh, TK, 2021) |
| " Because the administration of 2-acetylaminofluorene (2AAF) followed by a partial hepatectomy, selectively induces the HPC proliferation, we investigated the effects of chronic 2AAF administration on the HCC development caused by the chronic administration of the carcinogen diethylnitrosamine (DEN) for 16 weeks in the rat." | 1.62 | Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo. ( Arellanes-Robledo, J; Castro-Gil, MP; Del-Pozo-Jauner, L; Gabiño-López, NB; López-Torres, CD; Pérez-Carreón, JI; Quintanar-Jurado, V; Sánchez-Rodríguez, R; Torres-Mena, JE; Villa-Treviño, S, 2021) |
| "Alogliptin is an anti-diabetic that may have effective anticancer properties against many types of malignancies." | 1.62 | Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. ( Abd Elmaaboud, MA; Arab, HH; Kabel, AM, 2021) |
| "Liver cancer was induced in mice with hepatocyte-specific disruption of Myc and control mice by administration of diethylnitrosamine." | 1.62 | Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. ( Cai, J; Chen, L; Gao, Y; Gonzalez, FJ; Guo, X; Jiang, J; Krausz, KW; Liu, W; Luo, Y; Qu, A; Sun, L; Takahashi, S; Tang, W; Wang, Y; Xie, C; Yang, S; Yang, Y, 2021) |
| " However, the bioavailability of ABZ is very poor." | 1.62 | Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression. ( Amin, NA; Batiha, GE; El-Ahwany, E; El-Rous, MA; Elagamy, HI; Elewa, YHA; Elsergany, RN; Girgis, S; Gobba, NA; Hafez, AM; Kaddah, MMY; Kamal, I; Khodir, AE; Mahmoud, MH; Mourad, AAE; Nasr, M; Saad, AS; Saber, S; Shata, A, 2021) |
| "We compared gene expression profiles of Morris Hepatoma (MH3924a) and DEN (diethylnitrosamine)-induced HCC models to those of liver tissues from normal and rapidly regenerating liver models, and performed gain- and loss-of-function studies of the identified gene targets for their roles in cancer cell proliferation in vitro and in vivo." | 1.56 | Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis. ( Chow, P; Denil, S; Ding, Z; Ericksen, RE; Escande-Beillard, N; Gruenewald, S; Haegebarth, A; Han, W; Lee, QY; Loh, A; Reversade, B; Steckel, M; Toh, HC; Wai Ho, TS, 2020) |
| "ET in the prevention of liver cancer is poorly understood." | 1.56 | Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine. ( Cao, L; Ding, S; Ji, B; Li, L; Qi, Z; Zhang, X, 2020) |
| "Follow-up screening was performed in hepatocellular carcinoma with a focused CRISPR library targeting imaging-related genes." | 1.56 | Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer. ( Ackerman, D; Gade, TPF; Johnson, O; Mercadante, M; Perkons, NR; Pilla, G; Profka, E, 2020) |
| "Diethylnitrosamine (DEN) was used to induce HCC in a high-fat diet (HFD)-induced multigenerational obesity model." | 1.56 | Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p. ( Geng, M; Huang, K; Liu, S; Liu, Y; Petersen, RB; Sun, Y; Wang, Q; Wei, Y; Yue, J; Zhang, Y; Zheng, L, 2020) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 1.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| "The present study used human hepatoma cell lines and rats with diethylnitrosamine (DEN)‑induced HCC as models to investigate the association between the effect of EGCG on liver cancer and regulation of the p21waf1/Cip1/CDC25A axis." | 1.56 | Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A. ( An, H; Cai, Z; Cao, J; Chen, N; Li, K; Li, Y; Luo, A; Peng, Y; Tang, Y; Tao, H, 2020) |
| "GSTZ1 deficiency significantly promoted hepatoma cell proliferation and aerobic glycolysis in HCC cells." | 1.51 | GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. ( Chen, C; Lei, C; Li, J; Liang, L; Tang, N; Wang, K; Wang, Q; Xia, J; Yang, F; Yang, Y, 2019) |
| "Sorafenib (SO) is a multi-kinase inhibitor that targets upstream signals in the MAPK pathway." | 1.51 | Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma. ( Ghanim, AMH; Saber, S; Younis, NS, 2019) |
| "Identification of events leading to hepatocellular carcinoma (HCC) progression is essential for understanding its pathophysiology." | 1.51 | Elevated Expression of A-Raf and FA2H in Hepatocellular Carcinoma is Associated with Lipid Metabolism Dysregulation and Cancer Progression. ( Jain, SK; Ranjpour, M; Wajid, S, 2019) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 1.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| " Due to poor solubility and low bioavailability SYL lacks satisfactory therapeutic value thus designing a suitable and effective delivery system of SYL can led to improved therapeutic potential." | 1.51 | Dextrose modified bilosomes for peroral delivery: improved therapeutic potential and stability of silymarin in diethylnitrosamine-induced hepatic carcinoma in rats. ( Dwivedi, M; Parashar, P; Rana, P; Saraf, SA, 2019) |
| "Hepatitis and hepatocellular carcinoma are serious human diseases." | 1.51 | Extracts of Qizhu decoction inhibit hepatitis and hepatocellular carcinoma in vitro and in C57BL/6 mice by suppressing NF-κB signaling. ( Fang, NY; Shen, JJ; Wan, LF; Wang, YH; Xue, BY; Yuan, X; Zhao, W, 2019) |
| "Primary hepatic angiosarcoma is a rare tumor with poor prognosis." | 1.51 | Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs. ( Golob-Schwarzl, N; Haybaeck, J; Hofer, EM; Hoppstädter, J; Kessler, SM; Lackner, C; Leber, B; Liegl-Atzwanger, B; Mischinger, HJ; Schultheiss, CS; Stiegler, P, 2019) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 1.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "In the NAFLD pigs, hepatic histology of nonalcoholic steatohepatitis (NASH) was observed at 36 weeks, and HCC developed at 60 weeks." | 1.51 | Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study. ( Aizawa, N; Hatano, E; Iguchi, K; Iijima, H; Ikegawa, M; Kawaguchi, H; Nakamura, N; Nishiguchi, S; Ohtsu, I; Okuda, Y; Sakurai, T; Sato, M; Seo, S; Taura, K; Tomono, T; Uemoto, S; Wada, S, 2019) |
| "Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC)." | 1.48 | Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis. ( Inoue-Yamauchi, A; Itagaki, H; Oda, H, 2018) |
| "Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis." | 1.48 | In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa ( Fathy, M; Nikaido, T, 2018) |
| "Obesity is associated with both endoplasmic reticulum (ER) stress and chronic metabolic inflammation." | 1.48 | Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice. ( Cai, J; Chen, T; Dai, J; Fang, J; Feng, Y; Liu, J; Liu, Y; Lv, S; Rui, L; Shan, B; Wang, Y; Wu, Y; Xia, Z; Xie, D; Zheng, L, 2018) |
| "The most common form of liver cancer is hepatocellular carcinoma (HCC)." | 1.48 | WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia. ( Abu-Remaileh, M; Aqeilan, RI; Khalaileh, A; Pikarsky, E, 2018) |
| "In a nutritional model of hepatocarcinogenesis, the protein Nrf2 is frequently mutated/activated at early steps of the tumorigenic process." | 1.48 | Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. ( Columbano, A; Orrù, C; Perra, A; Szydlowska, M; Taguchi, K; Yamamoto, M; Zavattari, P, 2018) |
| "In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous treatment." | 1.48 | Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice. ( Álvarez, ML; Arboatti, AS; Carnovale, CE; Francés, DEA; Lambertucci, F; Monti, J; Pisani, G; Ronco, MT; Sedlmeier, MG, 2018) |
| "Diethylnitrosamine was used to induce liver cancer in a rat model." | 1.48 | Correlation between HSD17B4 expression in rat liver cancer tissues and inflammation or proliferation. ( Lin, Z; Pan, LC; Xiao, HY; Yin, WJ, 2018) |
| "In the rat hepatocarcinogenesis model, unexpectedly, CYP2E1 activity was found to decrease from hepatofibrosis to hepatocarcinogenesis." | 1.48 | From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor. ( Gao, J; Gao, N; Jin, H; Li, J; Qiao, HL; Wang, GJ; Wang, Z; Wen, Q; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| "Induced liver cancer mice showed depressed mental status, early onset of hepatitis and liver cirrhosis." | 1.48 | Investigation of PD-1H in DEN-induced mouse liver cancer model. ( Lei, CJ; Li, Y; Long, ZX; Pan, QY; Ren, H; Wang, B, 2018) |
| "Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC)." | 1.48 | Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis. ( Dozmorov, M; Fisher, PB; Ghosh, S; Jariwala, N; Lai, Z; Mendoza, RG; Mukhopadhyay, ND; Robertson, CL; Sarkar, D; Subler, MA; Windle, JJ, 2018) |
| "Hepatic cancer is well known, and leading cancer around the world and remain asymptomatic diseases." | 1.48 | Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles. ( Falls, N; Kumar, V; Ramteke, PW; Singh Dangi, D; Singh, D; Singh, M; Verma, A; Yadav, E, 2018) |
| "At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally." | 1.48 | The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice. ( Chen, XZ; Li, XJ; Li, YS; Shang, HC; Tang, HB; Tian, GH; Zhang, WK, 2018) |
| "Both incidence and death rate due to liver cancer have increased in the United States." | 1.48 | Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes. ( Aizawa, K; Fu, M; Hiroyuki, S; Hu, KQ; Li, CC; Liu, C; Takahashi, S; Wang, XD; Wu, G; Xia, H; Zhao, L, 2018) |
| "In the DEN-treated mice, AICAR treatment reduced tumorigenesis, IL-6 signaling, and STAT3 activation." | 1.48 | The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN). ( Gao, J; Jiang, G; Xiong, D; Xiong, R; Yin, T; Yin, Z; Zhang, S; Zhang, X; Zhao, W, 2018) |
| "Human hepatocellular carcinomas (HCCs), which arise on a background of chronic liver damage and inflammation, express c-Fos, a component of the AP-1 transcription factor." | 1.46 | Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation. ( Bakiri, L; Campos-Olivas, R; Dienes, HP; Graña, O; Guío-Carrión, A; Hamacher, R; Hasenfuss, SC; Martinez, L; Thomsen, MK; Wagner, EF, 2017) |
| "Dieckol (DEK) is a major polyphenol of marine brown seaweed Ecklonia cava which is a potential candidate for cancer therapy." | 1.46 | Modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes, cell proliferation, apoptosis, invasion and angiogenesis during NDEA-induced rat hepatocarcinogenesis. ( Duraikannu, A; Fredrick, WS; Gobalakrishnan, R; Kodisundaram, P; Ravichandran, S; Sadeeshkumar, V, 2017) |
| "Determining the origin of liver cancer stem cells is important for treating hepatocellular carcinoma." | 1.46 | Tg737 regulates epithelial-mesenchymal transition and cancer stem cell properties via a negative feedback circuit between Snail and HNF4α during liver stem cell malignant transformation. ( Bian, Z; Chen, C; Dai, B; Huang, Q; Liu, W; Pu, M; Qu, X; Shen, L; Tang, H; Tao, K; Zhao, G, 2017) |
| "Examination of liver cancer in diethylnitrosamine (DEN)-treated CUGBP1-S302A mice showed these mice develop much more severe liver cancer that is associated with elimination of the mutant CUGBP1." | 1.46 | RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner. ( Cast, A; Iakova, P; Karns, R; Lewis, K; Stock, L; Timchenko, L; Timchenko, N; Valanejad, L; Wei, C; Wright, M, 2017) |
| "The global burden of hepatocellular carcinoma is increasing; actually, it is estimated as 750,000 new cases annually." | 1.46 | Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study. ( Aglan, HA; Ahmed, HH; El-Toumy, SA; Mahmoud, NS, 2017) |
| "Non-alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of conditions, ranging from non-progressive bland steatosis to hepatocarcinoma." | 1.46 | Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. ( Bischetti, S; Casagrande, V; Federici, M; Mauriello, A; Mavilio, M; Menghini, R, 2017) |
| "Hepatocellular carcinoma was induced with 20 mg diethylnitrosamine/kg BW." | 1.46 | Gamma-irradiated β-glucan modulates signaling molecular targets of hepatocellular carcinoma in rats. ( Elsonbaty, SM; Moawed, FS; Zahran, WE, 2017) |
| "Rats from all groups were assessed for liver cancer progression or inhibition by evaluating histological, biochemical, antioxidant enzyme status, cytokines and gene expression profiles." | 1.46 | Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats. ( Abuzenadah, A; Al-Qahtani, M; Barbour, E; Chaudhary, A; Kalamegam, G; Khan, F; Khan, TJ; Kumosani, T; Pushparaj, PN, 2017) |
| "Treatment with crocin-coated MNPs was associated with regression of precancerous lesions, significant upregulation of apoptotic cells and downregulation of Bcl-2 labeling and markers of cell proliferation, inflammation, oxidative stress and angiogenesis." | 1.46 | Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles. ( Amin, A; El-Kharrag, R; Greish, Y; Hisaindee, S; Karam, SM, 2017) |
| "The high recurrence/metastasis of HCC is the main cause of death for HCC patients after liver resection." | 1.46 | miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver. ( Chen, XB; Feng, L; Tang, JW; Xu, LL; Xu, MQ; Yi, PS; Zhang, M; Zheng, XB, 2017) |
| "Diethylnitrosamine (DEN) was used to induce liver cancer in mice followed by actein treatment at different concentrations." | 1.46 | Actein ameliorates hepatobiliary cancer through stemness and p53 signaling regulation. ( Wang, LJ; Xi, R, 2017) |
| "Blocking lipogenesis in cultured liver cancer cells is sufficient to decrease cell viability; however, it is not known whether blocking lipogenesis in vivo can prevent liver tumorigenesis." | 1.46 | Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. ( Breen, DS; Byrne, FL; Caldwell, SH; Chow, JD; Cooney, GJ; Hargett, SR; Hoehn, KL; James, DE; Lackner, C; Lahiri, S; Nelson, ME; Olzomer, EM; Slack-Davis, JK; Turner, N; Wu, LE, 2017) |
| "Our findings showed that in hepatocarcinogenesis by diethylnitrosamine, cellular senescence is associated with p16 pathway activation and is mainly localized in myofibroblast-like cells." | 1.43 | Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. ( Alemán-Lazarini, L; Arellanes-Robledo, J; Fattel-Fazenda, S; Pacheco-Rivera, R; Pérez-Carreón, J; Rodríguez-Segura, M; Serrano-Luna, J; Shibayama, M; Silva-Olivares, A; Villa-Treviño, S, 2016) |
| "Without treatment, NAFLD may progress to hepatocellular carcinoma (HCC), a cancer with a high mortality rate." | 1.43 | Dietary Broccoli Lessens Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and Fed a Western or Control Diet. ( Chen, YJ; Jeffery, EH; Wallig, MA, 2016) |
| "Overnutrition can promote liver cancer in mice and humans that have liver damage caused by alcohol, viruses, or carcinogens." | 1.43 | Dietary sugar intake increases liver tumor incidence in female mice. ( Breen, DS; Byrne, FL; Caldwell, SH; Chow, JD; Hargett, SR; Healy, ME; Hoehn, KL; Kenwood, BM; Lackner, C; Lahiri, S; Taddeo, EP, 2016) |
| "Wister rat model of liver cancer was set up using diethylnitrosamine (DEN)." | 1.43 | Correlation between angiogenic/inflammatory mediators in Wister rat model of liver dysplasia. ( Adel, S; Nasr, MI; Salem, TA; Talaat, RM, 2016) |
| "Bid participates in hepatic carcinogenesis but the mechanism is not fully understood." | 1.43 | Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. ( Chen, X; Dong, Z; Khambu, B; Luo, J; Michalopoulos, GK; Wu, S; Yan, S; Yin, XM; Yu, C, 2016) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 1.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "Indeed, primary liver cancers were nearly fourfold as frequent in Per2m/m mice as compared to wild-type (WT), 4 months after DEN exposure." | 1.43 | Clock gene Per2 as a controller of liver carcinogenesis. ( Filipski, E; Guettier, C; Lévi, F; Mteyrek, A; Okyar, A, 2016) |
| "The incidence of liver cancer is higher in men than in women." | 1.43 | Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse. ( Grant, DM; Hanna, D; Riedmaier, AE; Sugamori, KS, 2016) |
| "The impact of gp96 status on hepatic carcinogenesis in response to diethyl-nitrosoamine (DENA) was probed." | 1.42 | Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. ( Chiosis, G; Clarke, CJ; Cowart, LA; Drake, RR; Hannun, YA; Jones, E; Li, Z; Liu, B; Ogretmen, B; Rachidi, S; Sun, S; Wu, BX, 2015) |
| "After DEN-induced hepatocellular carcinoma (HCC) in rats showed increased phosphorylation of JNK1/2, p38, and ERK1/2, we next antagonized TGF-β1-induced phosphorylation of JNK1/2, p38, ERK1/2, Smad2/3 signaling in HepG2 cells using SP600125, SB203580, and PD98059, respectively." | 1.42 | MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells. ( Boye, A; He, S; Jiang, Y; Kan, H; Wu, C; Yang, X; Yang, Y, 2015) |
| "Caudatin is a potential antitumor agent isolated from the traditional Chinese medicine "baishouwu", which was the root tuber of Cynanchum auriculatum Royle ex Wight." | 1.42 | Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats. ( Ding, Y; Peng, Y, 2015) |
| "The treatment with astemizole prevented diethylnitrosamine (DEN)-induced rat HCC development in vivo (followed by studying γ-glutamyl transpeptidase (GGT) activity)." | 1.42 | Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1 channels as potential early-stage markers of HCC. ( Acuña-Macías, I; Camacho, J; Caro-Sánchez, CH; Chiliquinga, AJ; de Guadalupe Chávez-López, M; Díaz-Chávez, J; Gariglio, P; Hernández-Gallegos, E; Herrera, LA; Pérez-Carreón, JI; Zuñiga-García, V, 2015) |
| "Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear." | 1.42 | Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015) |
| "Experimentally induced hepatocellular carcinoma is considered one of the representative laboratory models for studying this process." | 1.42 | Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells. ( Cai, JC; Cathopoulis, T; Han, R; Li, X; Liu, F; Liu, GY; Lu, K; Luo, G; Peng, B; Shi, SL; Yang, L, 2015) |
| "Fgl1 expression is decreased in hepatocellular carcinoma (HCC) and its loss correlates with a poorly differentiated phenotype." | 1.42 | Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. ( Bronson, RT; Cohen, DE; Demchev, V; Desai, A; Hornick, JL; Nayeb-Hashemi, H; Ukomadu, C, 2015) |
| "The results revealed that NDEA-induced hepatic cancer tumor tissue had altered molecular composition compared with normal liver tissue." | 1.42 | Fourier Transform Infrared Spectroscopic Studies on Modulation of N-Nitrosodiethylamine-Induced Hepatocarcinogenesis by Azadirachta indica. ( Bharati, S; Koul, A; Rishi, P, 2015) |
| "Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC)." | 1.42 | Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis. ( Chung, YA; Ham, HJ; Jang, KS; Jung, YJ; Lee, J; Lee, JH; Maeng, LS; Park, MS; Park, SI, 2015) |
| "Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date." | 1.42 | Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients. ( Hu, C; Huang, X; Lin, X; Niu, J; Tan, Y; Wang, H; Wang, X; Yin, P; Zeng, J; Zhou, L, 2015) |
| "Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 1.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
| "Alcoholic liver disease, chronic hepatitis B and chronic hepatitis C are the most common underlying liver diseases." | 1.40 | Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53. ( Calabrese, D; Dietsche, T; Dill, MT; Duong, FH; Heim, MH; Ketterer, S; Makowska, Z; Matter, MS; Terracciano, L, 2014) |
| "A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used." | 1.40 | Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014) |
| "Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1α hepatic expression." | 1.40 | Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Hamed, O; Kazem, A; Nasr, M; Selima, E, 2014) |
| "Lycopene is an active chemopreventive agent that offers protection against DEN-induced hepatocarcinogenesis by inhibiting NF-κB and mTOR pathways." | 1.40 | Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways. ( Ali, S; Bahcecioglu, IH; Guler, O; Ilhan, N; Kucuk, O; Orhan, C; Ozercan, I; Sahin, K; Sahin, N; Tuzcu, M, 2014) |
| " indica leaf extract (AAILE) was administered orally at a dosage of 100 μg/g body mass till the termination of experiment." | 1.40 | Azadirachta indica modulates electrical properties and type of cell death in NDEA-induced hepatic tumors. ( Bharati, S; Koul, A; Rishi, P, 2014) |
| "Molecular mechanisms responsible for hepatocellular carcinoma (HCC) remain largely unknown." | 1.40 | Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. ( Bakiri, L; Djouder, N; Gomes, AL; Graña, O; Pisano, DG; Rodriguez-Justo, M; Ruppen, I; Sheshappanavar, V; Tummala, KS; Wagner, EF; Ximénez-Embún, P; Yilmaz, M, 2014) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 1.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| "In human hepatocellular carcinoma tumors, high levels of CXCR4 always correlated with activation of the TGF-β pathway, a less differentiated phenotype, and a cirrhotic background." | 1.39 | Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells. ( Bertran, E; Caja, L; Crosas-Molist, E; Egea, G; Fabregat, I; Lastra, R; Lopez-Luque, J; Navarro, E; Ramos, E; Sancho, P; Serrano, T, 2013) |
| "Real-time analyses of hepatocellular carcinoma were performed in living mice to assess the applicability of probe electrospray ionization-mass spectrometry (PESI-MS) in medical diagnosis." | 1.39 | Real-time diagnosis of chemically induced hepatocellular carcinoma using a novel mass spectrometry-based technique. ( Chen, LC; Fujii, H; Hara, M; Hiraoka, K; Mandal, MK; Takeda, S; Tanabe, K; Yoshimura, K, 2013) |
| "Treatment options for hepatocellular carcinoma using chemotherapeutics at intermediate and advanced stages of disease are limited as patients most rapidly escape from therapy and succumb to disease progression." | 1.39 | Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance. ( Berger, W; Grubinger, M; Gucky, T; Haider, C; Jorda, R; Kryštof, V; Miklos, W; Mikulits, W; Řezníčková, E; Rotheneder, H; Strnad, M; Weiss, TS; Zatloukal, M, 2013) |
| "Phenobarbital (PB) is a cytochrome P450 (CYP) 2B inducer, and piperonyl butoxide (PBO) is a CYP1A/2B inducer." | 1.39 | Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide. ( Akane, H; Itahashi, M; Mitsumori, K; Morita, R; Nakane, F; Shibutani, M; Shiraki, A; Suzuki, K; Yafune, A, 2013) |
| "The findings suggest that RGP prevents hepatocellular carcinoma by suppressing the marked increase in the levels of serum marker enzymes, and suppresses the free radical by scavenging hydroxyl radicals." | 1.39 | Anticancer potential of rhamnocitrin 4'-β-D-galactopyranoside against N-diethylnitrosamine-induced hepatocellular carcinoma in rats. ( Ahmad, K; Ahmad, P; Al-Harbi, NO; Alam, MJ; Imam, F; Iqbal, M; Khusroo, MJ; Rahman, RU; Saleem, S; Shaharyar, MA, 2013) |
| "Group-II animals were kept untreated as hepatocellular carcinoma control." | 1.39 | Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats. ( Jhala, M; Joseph, JP; Kumar, P; Raval, SK; Sadariya, KA, 2013) |
| "Liver cancer, predominantly hepatocellular carcinoma (HCC), represents a complex and fatal malignancy driven primarily by oxidative stress and inflammation." | 1.39 | Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis. ( Bhatia, D; Bishayee, A; Darvesh, AS; Meszaros, JG; Ohanyan, V; Thoppil, RJ, 2013) |
| " indica leaf extract (AAILE) was administered orally at a dosage of 100 μg/g body weight thrice a week till termination of the study." | 1.38 | Azadirachta indica exhibits chemopreventive action against hepatic cancer: Studies on associated histopathological and ultrastructural changes. ( Bharati, S; Koul, A; Rishi, P, 2012) |
| "Hepatocellular carcinoma is becoming one of the most prominent types of cancer in the world." | 1.38 | Activity of tumor necrosis factor-α blocked by phytoglycoprotein (38 kDa) at initiation stage in N-nitrosodiethylamine-induced ICR mice. ( Lee, J; Lim, KT, 2012) |
| "We propose a novel mechanism for aneuploidy generation that involves impaired telomere replication upon loss of cohesin-SA1, with clear implications in tumourigenesis." | 1.38 | Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. ( Blasco, MA; Cañamero, M; Carretero, M; Cuadrado, A; Drosopoulos, WC; Losada, A; Martínez, P; Remeseiro, S; Schildkraut, CL, 2012) |
| "This experiment was designed to compare the effect of two selenium sources at the dosage of therapeutic level on hepatocarcinogenesis and angiogenic cytokines in DEN-induced hepatocarcinoma rats to further approach their possible anticancer's mechanism." | 1.38 | Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. ( Liu, JG; Liu, YJ; Liu, YW; Wang, XL; Zhao, HJ, 2012) |
| "Decreased KLF6 expression in human hepatocellular carcinoma (HCC) correlates with increased mortality, but the contribution of increased SV1 is unknown." | 1.38 | Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing. ( Cohen-Naftaly, M; Friedman, SL; Hannivoort, R; Kocabayoglu, P; Lee, YA; M Llovet, J; Narla, G; Thung, SN; Vetter, D; Villanueva, A, 2012) |
| "Liver tumor, especially hepatocellular carcinoma (HCC), is closely associated with chronic inflammation." | 1.38 | Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. ( Gan, Y; He, C; Huang, W; Lou, G; Meng, Z; Ness, CV; Wang, X; Wu, J; Xu, R; Yu, H; Zhang, Y; Zhou, H, 2012) |
| "The levels of liver cancer markers, including α-fetoprotein and carcinoembryonic antigen, were substantially increased by NDEA treatment." | 1.38 | Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats. ( Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M, 2012) |
| " These results provide a rationale for long-term MET dosing in future clinical trials of HCC treatment." | 1.37 | Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma. ( Bae, SH; Choi, JY; Jang, JW; Jung, CK; Kwon, JH; Park, ST; Yoon, SK; You, CR, 2011) |
| "Inactivation of KLF6 is common in hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) infection, thereby abrogating its normal antiproliferative activity in liver cells." | 1.37 | Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation. ( Friedman, SL; Hannivoort, R; Hoshida, Y; Lee, UE; Llovet, JM; Narla, G; Oren, M; Tarocchi, M; Vetter, D; Villanueva, A, 2011) |
| "A small animal imaging system for hepatocellular carcinoma (HCC)-specific reporter gene expression will enable monitoring of carcinogenesis or therapeutic intervention in vivo." | 1.37 | Non-invasive monitoring of hepatocellular carcinoma in transgenic mouse with bioluminescent imaging. ( Cheon, GJ; Kang, JH; Kim, KI; Kim, KM; Lee, TS; Lee, YJ; Lim, SM; Nahm, SS; Park, JH; Park, YS, 2011) |
| " The chromosomal aberration evaluation revealed a discrete dose-response curve." | 1.37 | N-nitrosodiethylamine genotoxicity evaluation: a cytochrome P450 induction study in rat hepatocytes. ( Aiub, CA; Eckl, P; Felzenszwalb, I; Ferreira, F; Gadermaier, G; Pinto, LF; Silva, IO, 2011) |
| "p53 Mutations are very common in human hepatocellular carcinoma, and induction of hepatic p53 expression causes lysis of implanted hepatoblastoma cells in a chimeric mouse." | 1.36 | Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. ( Dan, YY; Farrell, G; Fausto, N; Gu, Y; Hou, J; Mitchell, C; Pyakurel, P; Swisshelm, K; Teoh, N, 2010) |
| "Also, hepatoma cells use PDGFRalpha/PIK3CA signaling as an escape mechanism following beta-catenin suppression, and their sequential suppression profoundly impedes tumor proliferation." | 1.36 | Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. ( Kim, Y; Klaunig, JE; Misse, A; Monga, SP; Singh, S; Tan, X; Zeng, G; Zhang, XF, 2010) |
| "Chromosomal instability is a characteristic feature of hepatocellular carcinoma (HCC) but its origin and role in liver carcinogenesis are undefined." | 1.35 | Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice. ( Dan, YY; Fausto, N; Gu, Y; Haque, J; Lehman, S; Swisshelm, K; Teoh, NC; Wright, JH, 2008) |
| "Fenofibrate (FF) has previously been shown to induce hepatocellular neoplasia in a conventional mouse bioassay (NDA 1993), but there has been no report to examine the carcinogenic susceptibility of rasH2 mice to this chemical." | 1.35 | Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice. ( Dewa, Y; Jin, M; Kawai, M; Matsumoto, S; Mitsumori, K; Nishimura, J; Saegusa, Y; Shibutani, M; Taniai, E, 2008) |
| " Simultaneously, hepatocarcinoma were induced in groups II-V by diethylnitrosamine (DEN) solution (100 mg/L) at the dosage of 10 mg/kg body weight every day as drinking water for 16 weeks, then sterilized water for a further two weeks." | 1.35 | Effect of selenium-enriched malt on hypoglycemia and regulatory hormones in diethylnitrosamine-induced hepatocarcinoma SD rats. ( Liu, JG; Liu, YJ; Wang, XL; Zhao, HJ, 2009) |
| "The development and progression of liver cancer may involve abnormal changes in DNA methylation, which lead to the activation of certain proto-oncogenes, such as c-myc, as well as the inactivation of certain tumor suppressors, such as p16." | 1.35 | Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model. ( Du, YP; Ling, WH; Peng, JS; Sun, A; Tang, ZH; Zhu, HL, 2009) |
| "NDEA-induced rats showed severe hyperlipidemia along with upregulated expression of COX-2 as revealed by western blotting and immunohistochemistry." | 1.35 | Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma. ( Anandakumar, P; Augustine, TA; Devaki, T; Elinos-Báez, CM; Jagan, S; Kamaraj, S; Ramakrishnan, G, 2008) |
| "Ethacrynic acid (EA) is an inhibitor of rat and human GSTs." | 1.34 | Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity. ( Alvarez, Mde L; Carnovale, C; Carrillo, MC; Francés, D; Parody, JP; Quiroga, A; Ronco, MT, 2007) |
| "Pioglitazone treatment was initiated the day after the first diethylnitrosamine injection." | 1.34 | The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver. ( Borbath, I; Horsmans, Y; Leclercq, I; Moulin, P; Sempoux, C, 2007) |
| "Within the scope of the Rat Liver Foci Bioassay the model carcinogens N-nitrosomorpholine (NNM), 2-acetylaminoflouren (2-AAF), phenobarbital (PB), and clofibrate (CF) were analyzed concerning their potency and dose-response relationship to induce foci of altered hepatocytes (FAHs), which are known to be precursor lesions of liver adenoma and carcinoma." | 1.34 | Comparison of mode of action of four hepatocarcinogens: a model-based approach. ( Bannasch, P; Groos, J; Kopp-Schneider, A; Schwarz, M, 2007) |
| "Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of beta1-ARs, extensive areas completely devoid of beta1-ARs being mingled with areas showing a weak immunostaining." | 1.33 | Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats. ( Cardani, R; Zavanella, T, 2005) |
| "In murine and human hepatoma cells, IRS-2 protein induction associated with increased IRS-2 mRNA levels." | 1.33 | Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma. ( Beurel, E; Boissan, M; Desbois-Mouthon, C; Housset, C; Lacombe, ML; Lécluse, Y; Rey, C; Wendum, D, 2005) |
| "Incidences of lung metastasis in the 40 ppm group steadily increased up to 67% by week 36 while that in the 80 ppm increased sharply up to 86% by week 24." | 1.33 | Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. ( Cho, YM; Futakuchi, M; Imai, N; Ogawa, K; Shirai, T; Takeshita, F; Tamano, S; Yoshino, H, 2005) |
| " Two reports recorded the appearance of tumors after treatment with NDEA, although one used a different dosing schedule that included phenobarbital promotion." | 1.33 | Concordance of thresholds for carcinogenicity of N-nitrosodiethylamine. ( Fukushima, S; Waddell, WJ; Williams, GM, 2006) |
| " Two weeks later, daily dosing of 0." | 1.32 | Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. ( Andersen, ME; Chubb, LS; Conolly, RB; Dobrev, ID; Gustafson, DL; Lapidot, SA; Long, ME; Ou, YC; Thomas, RS; Xu, Y; Yang, RS, 2003) |
| " We conclude that long-term intake of TRF could reduce cancer risk by preventing hepatic lipid peroxidation and protein oxidation damage due to its antioxidant actions." | 1.32 | Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil. ( Beg, ZH; Iqbal, J; Minhajuddin, M, 2004) |
| "Melatonin treatment were performed only during the night (between 18:00 to 09:00) in order to maintain their circadian rhythm, since serum melatonin levels are high at midnight." | 1.31 | Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure. ( Asamoto, M; Futakuchi, M; Hagiwara, A; Imaida, K; Ogawa, K; Sano, M; Shirai, T; Tamano, S; Yoshino, H, 2000) |
| "Diethylnitrosamine-treated TT mice developed both preneoplastic and neoplastic lesions in the liver." | 1.31 | Enhancement of chemical hepatocarcinogenesis by the HIV-1 tat gene. ( Altavilla, G; Barbanti-Brodano, G; Caputo, A; Corallini, A; Lanfredi, M; Piola, C, 2000) |
| "For better understanding of cancer metastasis, we have established an in vivo model for induction of highly metastatic hepatocellular carcinomas (HCC) in male F344 rats." | 1.31 | Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice. ( Asamoto, M; Futakuchi, M; Imaida, K; Nakanishi, H; Ogawa, K; Shirai, T; Takeshita, F; Tatematsu, M, 2001) |
| "The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0." | 1.31 | Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001) |
| "In CDAA-induced liver fibrosis model, PE revealed a marked inhibitory effect of liver fibrosis development." | 1.31 | Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. ( Fukui, H; Ikenaka, Y; Imazu, H; Kuriyama, S; Nakatani, T; Noguchi, R; Tsujinoue, H; Yanase, K; Yoshii, J; Yoshiji, H, 2002) |
| "A stable and sensitive early marker of liver cancer--GST-Pi positive foci or nodule was measured by a immunohistochemical method." | 1.30 | [Inhibitory effects of tea polyphenols and tea pigments on liver precancerous lesions in rats]. ( Chen, J; Gong, Y; Han, C, 1999) |
| "Co-treatment of rotenone and WY-14,643 (group IV) decreased focal DNA synthesis and mitosis and increased the incidence of apoptotic hepatocytes." | 1.30 | Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone. ( Ayoubi, SA; Isenberg, JS; Klaunig, JE; Kolaja, KL; Watkins, JB, 1997) |
| "Diethylnitrosamine (DEN) was administered at the age of 8 weeks." | 1.30 | Chronic liver injury promotes hepatocarcinogenesis of the LEC rat. ( Enomoto, K; Hattori, A; Mori, M; Sawada, N; Sawaki, M; Sugawara, N; Tsuzuki, N, 1998) |
| "In contrast, five hepatoma cell lines (Fao, Faza, H5, HTC and RHC1) showed either a decrease or an absence of OCT1 expression compared to normal hepatocytes; these hepatoma cells also displayed lower intracellular accumulation of tetraethylammonium (TEA), a well-known substrate for OCT1." | 1.30 | Differential expression of the polyspecific drug transporter OCT1 in rat hepatocarcinoma cells. ( Fardel, O; Guillouzo, A; Lecureur, V, 1998) |
| "ras mRNA expression in liver neoplasms was also suppressed significantly (p < 0." | 1.30 | Suppressive effect of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats. ( Kajiwara, K; Komaki, C; Maki, T; Moriwaki, H; Muto, Y; Nagase, S; Okuno, M; Shiratori, Y; Tanaka, T, 1998) |
| "The average score of liver cirrhosis associated with HCV was 1." | 1.30 | Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. ( Hino, S; Kamahora, T; Kawasaki, H; Miyata, H; Shimada, A; Shiota, G; Shiraki, K; Terada, T, 1998) |
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 1.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| "Histologically, the tumors were hepatocellular carcinomas (HCCs) of trabecular, (pseudo)glandular and solid types with or without cholangiocellular involvement." | 1.30 | Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine. ( Ahn, B; Han, BS; Kim, DJ; Ohshima, H, 1999) |
| " Trend tests and a probit dose-response model showed a significantly positive correlation (p = 0." | 1.30 | N-nitrosodiethylamine initiation of carcinogenesis in Japanese medaka (Oryzias latipes): hepatocellular proliferation, toxicity, and neoplastic lesions resulting from short term, low level exposure. ( Brown-Peterson, NJ; Hawkins, WE; Krol, RM; Zhu, Y, 1999) |
| "Determining both the mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) acts as a tumor promoter and the shape of the dose-response curve at low doses remains an important goal of risk-assessment-directed research." | 1.30 | Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats. ( Dragan, YP; Goldsworthy, T; Pitot, HC; Singh, J; Teeguarden, JG; Vaughan, J; Xu, YH, 1999) |
| "We investigated the role of dosing regimen on ras mutations in chemically induced CD-1 mouse liver tumors." | 1.29 | Dose-related changes in the profile of ras mutations in chemically induced CD-1 mouse liver tumors. ( Hammermeister, CL; Joslyn, DJ; Kraynak, AR; Leander, KR; Ledwith, BJ; Manam, S; Nichols, WW; Prahalada, S; Shinder, GA; van Zwieten, MJ, 1995) |
| "These results show that rat hepatoma cells can display elevated levels of functional P-glycoprotein without any prior cytotoxic drug selection and suggest that these cells represent a useful model for analyzing P-glycoprotein regulation in intrinsically clinical drug-resistant cancers." | 1.29 | Constitutive expression of functional P-glycoprotein in rat hepatoma cells. ( Fardel, O; Glaise, D; Guillouzo, A; Lecureur, V; Loyer, P, 1994) |
| "Liver neoplasms were seen in Groups 1, 2 and 3." | 1.29 | Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats. ( Mori, H; Okumura, A; Sugie, S; Tanaka, T, 1993) |
| "HAM-6 was also slightly reactive to rat hepatocellular carcinoma, but not to normal or fetal rat liver, other normal rat organs, human hepatocellular carcinoma, or human liver cirrhosis." | 1.29 | Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens. ( Kurokawa, F, 1994) |
| "5." | 1.28 | Diethylnitrosamine-induced increase in gamma-glutamyltranspeptidase in rat liver: its association with thyroid hormone deficiency and its reversal by tri-iodothyronine. ( Pulga, VB; Sulakhe, SJ; Tran, ST, 1992) |
| "The gangliosides of human hepatoma biopsies, human hepatoma cell lines, and diethylnitrosamine-induced rat hepatomas were examined." | 1.28 | Enhanced expression of ganglioside GD3 in human and rat hepatocellular carcinoma cells and NIH 3T3 cells transfected with human tumor DNAs. ( Fuhrer, JP; Gao, NH; Gu, JR; Gu, TG; Lee, W; Murphy, MJ; Xia, LA; Ye, JN, 1990) |
| "Second, we found that in microscopic hepatic neoplasms in B6C3F1 mice, the thymidine labeling indices were 2." | 1.28 | Growth kinetics of microscopic hepatocellular neoplasms in carcinogen-resistant and carcinogen-responsive strains of mice. ( Goldfarb, S; Pugh, TD, 1992) |
| "The R16 males developed liver cancer and the R16 females developed breast cancer, there also were malignancies in other organs in some animals." | 1.28 | Genetic control of susceptibility to diethylnitrosamine and dimethylbenzanthracene carcinogenesis in rats. ( Gill, TJ; Kunz, HW; Melhem, MF, 1991) |
| "Aneuploidy was also present, as expected, in 4 of 33 AHF in the animals placed on CD + PHB." | 1.28 | Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model. ( Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM, 1990) |
| " The toxic depletion of hepatocytes and the attendant altered cellular environment are discussed in relation to cell-to-cell interactions and the possible contribution of stromal and extracellular matrix changes to liver regeneration and neoplasia." | 1.28 | Cytotoxicity phase of diethylnitrosamine-induced hepatic neoplasia in medaka. ( Hinton, DE; Laurén, DJ; Teh, SJ, 1990) |
| " Furthermore, chronic administration of 0." | 1.27 | Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats. ( Denda, A; Emi, Y; Konishi, Y; Mikami, S; Nakae, D; Ohnishi, T; Takahashi, S; Yokose, Y, 1984) |
| "In one, liver neoplasms were induced in P." | 1.27 | Characteristics of a fish colony of Poeciliopsis and its use in carcinogenicity studies with 7,12-dimethylbenz[a]anthracene and diethylnitrosamine. ( Schultz, ME; Schultz, RJ, 1984) |
| ") at 4 weeks of age with N-nitrosodiethylamine (DEN) at a dosage of 80 mg/kg." | 1.27 | Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice. ( Lynch, P; Ohshima, M; Riggs, C; Ward, JM, 1984) |
| "Sensitivity of hepatocytes to the proliferative stimulus (partial hepatectomy) and mitoinhibitory effect of carcinogen (toxic dose after operation) was studied during hepatic carcinogenesis induced by the chronic administration of diethylnitrosamine." | 1.27 | [Sensitivity of hepatocytes to the effect of factors stimulating and suppressing cell proliferation in hepatocarcinogenesis]. ( Osipova, LA, 1984) |
| " Under these experimental conditions, the long term administration of glutathione appears to have no observable influence on liver cancer development in this model." | 1.27 | Failure of glutathione to prevent liver cancer development in rats initiated with diethylnitrosamine in the resistant hepatocyte model. ( Ahluwalia, MB; Farber, E; Roomi, MW; Rotstein, J; Tatematsu, M, 1983) |
| " In the second experiment, the effect of chronic administration of PB and NAF given after I without S or after S without I was analyzed." | 1.27 | Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis. ( de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H, 1986) |
| " Similar dose-response data were obtained at various doses of two promoting agents effective in hepatocarcinogenesis, PB and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), in livers of F-344 female rats following initiation with DEN (10 mg/kg) 24 h post-70% hepatectomy." | 1.27 | A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci. ( Campbell, HA; Glauert, HP; Goldsworthy, TL; Kennan, W; Maronpot, RR; Moran, S; Pitot, HC, 1987) |
| " Therefore, we have begun to quantify the dose-response relationships for N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis by characterizing the major promutagenic DNA adduct, O4-ethyldeoxythymidine (O4-etdT); hepatocyte proliferation; and hepatocyte initiation in rats continually exposed to drinking-water containing NDEA." | 1.27 | Molecular dosimetry of DNA alkylation during chronic exposure to carcinogens. ( Boucheron, JA; Deal, FH; Richardson, FC; Swenberg, JA; Tyeryar, LA, 1987) |
| "Histological characterization of hepatocellular carcinoma, hemangiopericytic sarcoma, and cholangiocarcinoma and the development of the neoplasms in host fish is presented." | 1.27 | Transplantable chemically-induced liver tumors in the viviparous fish Poeciliopsis. ( Schultz, ME; Schultz, RJ, 1985) |
| "Diethylnitrosamine (NDEA) was administered subcutaneously to non-icteric and icteric Gunn rats." | 1.27 | The influence of metabolic liver defects on diethylnitrosamine (NDEA)-carcinogenesis in Gunn rats. ( Althoff, J; Fehst, HJ; Mohr, U, 1985) |
| "Diethylnitrosamine was used as initiating agent of hepatocarcinogenesis and lipid peroxidation levels were monitored in the homogenates from normal liver, hyperplastic nodules and tumour, incubated in the presence or in the absence of ascorbate or adenosine diphosphate-iron complex." | 1.27 | Resistance to oxidative stress by hyperplastic and neoplastic rat liver tissue monitored in terms of production of unpolar and medium polar carbonyls. ( Biasi, F; Biocca, ME; Canuto, RA; Cecchini, G; Chiarpotto, E; Dianzani, MU; Esterbauer, H; Muzio, G; Poli, G, 1986) |
| " The analysis of dose-response data showed first order kinetics (single event) regarding the induction of intermediate basophilic foci (IBF) and hepatocellular carcinomas (HCC)." | 1.27 | Certain aspects of hepatocarcinogenesis in the infant mouse model. ( Vesselinovitch, SD, 1987) |
| "Choline was not effective in inhibiting the development of lung metastases in either case." | 1.27 | Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats. ( Hoover, KL; Poirier, LA; Shivapurkar, N, 1986) |
| "In the other type, tumors differ from one another essentially via their growth rates." | 1.27 | The early growth of cancer. ( Chover, J; King, JH, 1985) |
| "Diethylnitrosamine was used as the initiator and phenobarbital and partial hepatectomy as promoters." | 1.26 | Short-term in vivo initiation/promotion bioassay for hepatocarcinogens. ( Ford, JO; Pereira, MA, 1980) |
| "Transplantable hepatomas varied in their fibronectin staining from fibronectin-negative hepatomas to ones with fibronectin staining within or around every tumor cell." | 1.26 | Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas. ( Ruoslahti, E; Sell, S, 1982) |
| "A new model of liver cancer development with chemicals is described." | 1.26 | Some conclusions derived from a liver model for carcinogenesis. ( Cameron, R; Farber, E, 1981) |
| "Methionine was contained in both the amino acid and the lipotrope supplement and probably was responsible for reducing hepatocarcinoma incidence." | 1.26 | Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet. ( Rogers, AE, 1977) |
| " DENA, which was administered to 38 rats in a dosage of 20 mg/kg/week, induced liver tumors in 90% of the animals; in 29% besides some precancerous stages predominantly malignant carcinomas of the oesophagus were seen." | 1.26 | Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats. ( Diehl, B; Habs, M; Krüger, FW; Schmähl, D, 1976) |
| " Dose-response relationships measured with diethylnitrosamine, the carcinogen with the lowest toxicity as compared with the carcinogenic action, indicated that island formation is due to a one-hit process, i." | 1.26 | Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis. ( Emmelot, P; Scherer, E, 1976) |
| "4 mg/kg body weight with a total dosage of 420 mg/kg over an experimental period of five years." | 1.26 | Hepatocarcinogenetic effect of DENA in pigs. ( Berg, H; Graw, JJ, 1977) |
| "The chronic administration of diethylnitrosamine in drinking water induces liver tumors in the rat." | 1.26 | [Study of the mitotic activity during the preneoplastic period in the liver of rats treated by diethylnitrosamine (author's transl)]. ( Barbason, H; Betz, EH; Fridman-Manduzio, A, 1976) |
| " Chronic administration of diethylnitrosamine slightly increased the hepatic methylcobalamin concentration, but this was not statistically significant." | 1.26 | Altered cobalamin distribution in rat hepatomas and in the livers of rats treated with diethylnitrosamine. ( Linnell, JC; Matthews, DM; Morris, HP; Poirier, LA; Quadros, EV, 1977) |
| "induced tumors of liver (hepatocellular cancers and adenomas), and of hematopoietic system (hemocytoblastosis)." | 1.26 | The induction of tumors in Rana temporaria with nitrosamines. ( Khudoley, VV, 1977) |
| " The highest activity was obtained with antisera (Cx-1) produced by repeated intravenous injections of living L-10 cells at high cell dosage, whereas intramuscular injections of living or glutaraldehyde-treated L-10 cells at similar frequency and cell dosage were less effective for the production of cytotoxic antibodies against L-10 cells." | 1.26 | Susceptibility to and escape from complement-mediated lysis of guinea-pig hepatoma line-10. ( Abe, S; Berczi, I; Sehon, AH, 1977) |
| "The pulmonary metastases were first detected in mice dying between 51 and 60 weeks of age (5%)." | 1.26 | Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice. ( Mihailovich, N; Rao, KV; Vesselinovitch, SD, 1978) |
| "N-diethylnitrosamine (DEN) was simultaneously administered with diazepam (DZP) or thiouracil (TU) once weekly for life to gerbils (Meriones unguiculatus)." | 1.26 | The influence of diazepam and thiouracil upon the carcinogenic effect of diethylnitrosamine in gerbils. ( Green, U; Ketkar, M, 1978) |
| "In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers." | 1.26 | Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice. ( McGuire, LJ; Poound, AW, 1978) |
| " It was pointed out that the direct measurement of the dose-response relation (l(d) approximately dm) yields only the number of hits contributed by the carcinogen applied anose rate is low or very low, the contribution of background process becomes significant, and these hits contribute to the power of time, r, of the incidence-time relation." | 1.26 | Multi-hit kinetics of tumor formation, with special reference to experimental liver and human lung carcinogenesis and some gneral conclusions. ( Emmelot, P; Scherer, E, 1977) |
| " DMN induced a considerable quantity of liver tumours, the highest incidence being demonstrated in the lowest dosage group." | 1.26 | Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine. ( Kmoch, N; Mohr, U; Reznik, G, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 297 (29.61) | 18.7374 |
| 1990's | 134 (13.36) | 18.2507 |
| 2000's | 140 (13.96) | 29.6817 |
| 2010's | 323 (32.20) | 24.3611 |
| 2020's | 109 (10.87) | 2.80 |
| Authors | Studies |
|---|---|
| Balaraman, G | 1 |
| Sundaram, J | 1 |
| Mari, A | 1 |
| Krishnan, P | 1 |
| Salam, S | 1 |
| Subramaniam, N | 2 |
| Sirajduddin, I | 1 |
| Thiruvengadam, D | 2 |
| Lu, Y | 4 |
| Pan, J | 3 |
| Zhu, X | 1 |
| Zhang, S | 5 |
| Liu, C | 10 |
| Sun, J | 3 |
| Li, Y | 11 |
| Chen, S | 3 |
| Huang, J | 2 |
| Cao, C | 2 |
| Wang, Y | 11 |
| Liu, T | 3 |
| Mamdouh, AM | 1 |
| Khodeer, DM | 1 |
| Tantawy, MA | 1 |
| Moustafa, YM | 1 |
| Xu, L | 2 |
| Yang, C | 3 |
| Wang, J | 11 |
| Li, Z | 6 |
| Huang, R | 1 |
| Ma, H | 1 |
| Ma, J | 1 |
| Wang, Q | 5 |
| Xiong, X | 1 |
| Fu, H | 1 |
| Liu, X | 4 |
| Jin, L | 1 |
| Lang, J | 1 |
| Hu, Z | 1 |
| Mao, W | 1 |
| Cheng, C | 1 |
| Shou, Q | 1 |
| Badr, AM | 1 |
| El-Ahwany, E | 4 |
| Goda, L | 1 |
| Nagy, F | 1 |
| Helal, N | 1 |
| El Deeb, S | 1 |
| Sakai, H | 4 |
| Yamada, Y | 2 |
| Kubota, M | 4 |
| Imai, K | 1 |
| Shirakami, Y | 4 |
| Tomita, H | 1 |
| Hara, A | 2 |
| Shimizu, M | 4 |
| Nabeel, AI | 1 |
| Mansour, SZ | 2 |
| Mahdy, EME | 1 |
| El-Mezayen, HA | 3 |
| Mohamed, SA | 1 |
| Ghufran, H | 1 |
| Azam, M | 1 |
| Mehmood, A | 1 |
| Butt, H | 1 |
| Riazuddin, S | 1 |
| Chao, X | 1 |
| Wang, S | 3 |
| Hlobik, M | 1 |
| Ballabio, A | 1 |
| Ni, HM | 1 |
| Ding, WX | 1 |
| Karanam, G | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I-II Study of Intratumoral Urelumab Combined With Nivolumab in Patients With Solid Tumors[NCT03792724] | Phase 1/Phase 2 | 32 participants (Anticipated) | Interventional | 2019-01-30 | Not yet recruiting | ||
| A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU)[NCT00978250] | Phase 2 | 95 participants (Actual) | Interventional | 2009-08-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Here is the count of participants with serious and non-serious adverse events assessed by the Common Terminology Criteria in Adverse Events (CTCAE v4.0). A non-serious adverse event is any untoward medical occurrence. A serious adverse event is an adverse event or suspected adverse reaction that results in death, a life threatening adverse drug experience, hospitalization, disruption of the ability to conduct normal life functions, congenital anomaly/birth defect or important medical events that jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the previous outcomes mentioned. (NCT00978250)
Timeframe: Date treatment consent signed to date off study, approximately 109 months and 16 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| 5-Fluro-2'-Deoxycytidine (FdCyd) + Tetrahydrouridine (THU) | 91 |
Response was measured using the Response Evaluation Criteria in Solid Tumors (RECIST). Complete response is disappearance of all target lesions. Partial response is at least a 30% decrease in the sum of the longest diameter (LD) of target lesions, taking as reference the baseline sum of the LD. (NCT00978250)
Timeframe: until subject progressed or went off study for other reasons (up to approximately 1 year)
| Intervention | percentage of participants (Number) |
|---|---|
| Non-Small Cell Cancer Stratum | 0.0 |
| Breast Cancer Stratum | 6.9 |
| Bladder Cancer Stratum | 5.6 |
| Head and Neck Cancer Stratum | 0.0 |
Progression-free survival (PFS) is defined as the time interval from start of treatment to documented evidence of disease progression. Disease progression was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) and is at least a 20% increase in the sum of the longest diameter (LD) of target lesions, taking as reference the smallest sum of the LD recorded since the treatment started or the appearance of one or more new lesions. (NCT00978250)
Timeframe: until subject progressed or went off study for other reasons (up to approximately 1 year)
| Intervention | months (Median) |
|---|---|
| Non-Small Cell Cancer Stratum | 2.3 |
| Breast Cancer Stratum | 3.7 |
| Bladder Cancer Stratum | 3.6 |
| Heand and Neck Cancer Stratum | 1.7 |
15 reviews available for diethylnitrosamine and Liver Neoplasms
| Article | Year |
|---|---|
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Diseas | 2022 |
Diethylnitrosamine-induced liver tumorigenesis in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Liver; Liver Neoplas | 2021 |
Alcohol consumption, Wnt/β-catenin signaling, and hepatocarcinogenesis.
Topics: Alcohol Drinking; Animals; beta Catenin; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, Inbr | 2015 |
Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Hepa | 2016 |
Immunotherapy of hepatocellular carcinoma: is there a place for regulatory T-lymphocyte depletion?
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellular; Diethylnitrosamine; | 2011 |
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; G | 2002 |
[Early histochemical markers of hepatocarcinogenesis].
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; alpha-Fetoproteins; Animals; Diethylnitrosamine; g | 1984 |
Properties of incomplete carcinogens and promoters in hepatocarcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Hepate | 1982 |
Minireview: dialkylnitrosamine bioactivation and carcinogenesis.
Topics: Alkylation; Animals; Biotransformation; Chemical Phenomena; Chemistry; Diethylnitrosamine; Dimethyln | 1980 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
The quantitation of altered hepatic foci during multistage hepatocarcinogenesis in the rat: transforming growth factor alpha expression as a marker for the stage of progression.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Count; Cell Transformation, Neoplastic; | 1995 |
On the participation of cytochrome P-450 in the mechanism of prevention of hepatic carcinogenesis.
Topics: Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Electron Spin Resonance Spectroscopy; L | 1976 |
Experimental carcinogenesis in small aquarium fishes.
Topics: 2-Acetylaminofluorene; Adenoma; Adenoma, Bile Duct; Aflatoxins; Animals; Benzopyrenes; Carcinogens; | 1976 |
Regulation of hepatic growth.
Topics: Alpha-Globulins; Animals; Carbon Tetrachloride Poisoning; Cell Cycle; Cell Division; Cyclic AMP; Die | 1986 |
Single-hit versus multi-hit concept of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylni | 1985 |
988 other studies available for diethylnitrosamine and Liver Neoplasms
| Article | Year |
|---|---|
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Farnesol; Inflammation; Liver; | 2021 |
Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Area Under Curve; Carcinoma, Hepatocellular; Diethylnitrosamin | 2021 |
In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma.
Topics: alpha-Fetoproteins; Amygdalin; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogen | 2021 |
Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diet, High-Fat; Diethylni | 2021 |
Safflower yellow reduces DEN-induced hepatocellular carcinoma by enhancing liver immune infiltration through promotion of collagen degradation and modulation of gut microbiota.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chalcone; Collagen; Diethylnitrosamine; Gastro | 2021 |
MicroRNA-26a systemic administration attenuates tumor formation in hepatocellular carcinoma mouse model.
Topics: Alkylating Agents; alpha-Fetoproteins; Animals; Apoptosis; Biomarkers; Carcinoma, Hepatocellular; Ca | 2021 |
The phosphorylated retinoid X receptor-α promotes diethylnitrosamine-induced hepatocarcinogenesis in mice through the activation of β-catenin signaling pathway.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Doxycycline; L | 2022 |
In vivo Study of a Newly Synthesized Chromen-4-one Derivative as an Antitumor Agent against HCC.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; bcl-2-Associated X Protein; | 2022 |
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamin | 2021 |
Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Topics: Alcohol Drinking; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinogenes | 2022 |
Potential anticancer effects of cyclo(-Pro-Tyr) against N-diethyl nitrosamine induced hepatocellular carcinoma in mouse through PI3K/AKT signaling.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Dipeptides; Liver Neoplasms; Male | 2022 |
Fuzheng Xiaozheng prescription relieves rat hepatocellular carcinoma through improving anti-inflammation capacity and regulating lipid related metabolisms.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Drugs, Chinese Herbal | 2022 |
Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin.
Topics: Androgens; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Disease P | 2021 |
Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; Fruit; Gene Ex | 2021 |
Early-Life Exposure to Low-Dose Cadmium Accelerates Diethylnitrosamine and Diet-Induced Liver Cancer.
Topics: Animals; Animals, Newborn; Cadmium; Choline; Diet, High-Fat; Diethylnitrosamine; Disease Models, Ani | 2021 |
Evaluation of anti-cancer effect of zerumbone and cisplatin on
Topics: Animals; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Fresh Water; Humans; Liver Neopla | 2022 |
Anti-hepatocellular carcinoma efficacy of Fuzheng Xiaozheng prescription and its interventional mechanism studies.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Resp | 2022 |
Ethanol supernatant extracts of Gynura procumbens could treat nanodiethylnitrosamine-induced mouse liver cancer by interfering with inflammatory factors for the tumor microenvironment.
Topics: Animals; Antineoplastic Agents, Phytogenic; Asteraceae; Diethylnitrosamine; Drugs, Chinese Herbal; E | 2022 |
1H-NMR-based metabolomics reveals the biomarker panel and molecular mechanism of hepatocellular carcinoma progression.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Male; Me | 2022 |
New Approach about the Signaling Crosstalk between IQGAPs/ NF- κB/IL-8 and PDCD5/p53/TRAIL Pathways that Modulate Malignant Transformation in Hepatocellular Carcinoma.
Topics: Animals; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2022 |
Comparative subcellular localization of NRF2 and KEAP1 during the hepatocellular carcinoma development in vivo.
Topics: Actin Cytoskeleton; Animals; Carcinoma, Hepatocellular; Cell Nucleus; Cyclooxygenase 1; Diethylnitro | 2022 |
Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats.
Topics: Animals; Antioxidants; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Lipids; Liver; Li | 2023 |
Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Diethylnitrosamine; Fruit; Glutathione; Glutathione | 2022 |
Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats.
Topics: Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Isofla | 2022 |
Anticancer Effect of Arbutin on Diethylnitrosamine-Induced Liver Carcinoma in Rats via the GRP and GADD Pathway.
Topics: Animals; Arbutin; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Rats | 2022 |
Suppressive effects of thymoquinone on the initiation stage of diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Antioxidants; Benzoquinones; Carcinoma, Hepatocellular; Diethylnitrosamine; Glutathione; Li | 2022 |
Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model.
Topics: Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Feasibility Studies; Liver N | 2023 |
Topics: Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; ErbB Receptors; Gamma Rays; Liver; Liver N | 2023 |
Calotropis gigantea stem bark extracts inhibit liver cancer induced by diethylnitrosamine.
Topics: Adenosine Triphosphate; Animals; Calotropis; Carcinogenesis; Caspase 3; Diethylnitrosamine; Doxorubi | 2022 |
Boron attenuated diethylnitrosamine induced hepatocellular carcinoma in C3H/HeN mice via alteration of oxidative stress and apoptotic pathway.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Boron; Carcinoma, Hepatocellular; Casp | 2022 |
Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Bilirubin; Body Weight; Carcinoma, Hepatocellular; Diethy | 2022 |
Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma.
Topics: alpha-Fetoproteins; Animals; Body Weight; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; | 2022 |
MitoQ demonstrates connexin- and p53-mediated cancer chemoprevention in N-nitrosodiethylamine-induced hepatocarcinogenesis rodent model.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Chemoprevention; Connexins; Diethylnitrosamine; | 2022 |
MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Fatt | 2022 |
Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3-mediated cancer development.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Humans; | 2022 |
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib | 2022 |
Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study.
Topics: Animals; beta Catenin; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; Fibrosis; Gold; Int | 2023 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
Vitamin D ameliorates diethylnitrosamine-induced liver preneoplasia: A pivotal role of CYP3A4/CYP2E1 via DPP-4 enzyme inhibition.
Topics: Animals; bcl-2-Associated X Protein; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Diethylnitrosa | 2023 |
Vitamin D ameliorates diethylnitrosamine-induced liver preneoplasia: A pivotal role of CYP3A4/CYP2E1 via DPP-4 enzyme inhibition.
Topics: Animals; bcl-2-Associated X Protein; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Diethylnitrosa | 2023 |
Vitamin D ameliorates diethylnitrosamine-induced liver preneoplasia: A pivotal role of CYP3A4/CYP2E1 via DPP-4 enzyme inhibition.
Topics: Animals; bcl-2-Associated X Protein; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Diethylnitrosa | 2023 |
Vitamin D ameliorates diethylnitrosamine-induced liver preneoplasia: A pivotal role of CYP3A4/CYP2E1 via DPP-4 enzyme inhibition.
Topics: Animals; bcl-2-Associated X Protein; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Diethylnitrosa | 2023 |
Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Liver Neoplasms; NF | 2022 |
Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Liver Neoplasms; NF | 2022 |
Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Liver Neoplasms; NF | 2022 |
Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Liver Neoplasms; NF | 2022 |
SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Liver Neoplasms; Mice; M | 2023 |
SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Liver Neoplasms; Mice; M | 2023 |
SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Liver Neoplasms; Mice; M | 2023 |
SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Liver Neoplasms; Mice; M | 2023 |
Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; Diet, High-Fat; Diethylnitrosamine; Diseas | 2023 |
Potential of siRNA-Bearing Subtilosomes in the Treatment of Diethylnitrosamine-Induced Hepatocellular Carcinoma.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; | 2023 |
Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; L | 2023 |
Intestinal microecology in mice bearing diethylnitrosamine-induced primary hepatocellular carcinoma.
Topics: Animals; Bacteria; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, | 2022 |
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Humans; Li | 2023 |
Lactosylated Chitosan Nanoparticles Potentiate the Anticancer Effects of Telmisartan In Vitro and in a
Topics: Animals; Carcinoma, Hepatocellular; Chitosan; Diethylnitrosamine; Hep G2 Cells; Humans; Liver Neopla | 2023 |
Novel miRNA-based drug CD5-2 reduces liver tumor growth in diethylnitrosamine-treated mice by normalizing tumor vasculature and altering immune infiltrate.
Topics: Animals; Diethylnitrosamine; Humans; Hypoxia; Infant; Liver Neoplasms; Mice; MicroRNAs; Tumor Microe | 2023 |
Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Estrogens; Fatty Acid Synthases; Female; Int | 2023 |
The essential role of O-GlcNAcylation in hepatic differentiation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Differentiation; Diethylnitrosamine; Fibrosis; Humans; Live | 2023 |
Hepatoprotective effects of aspirin on diethylnitrosamine-induced hepatocellular carcinoma in rats by reducing inflammation levels and PD-L1 expression.
Topics: Animals; Aspirin; B7-H1 Antigen; Carcinoma, Hepatocellular; Diethylnitrosamine; Inflammation; Liver | 2023 |
Whole transcriptome analysis of chemically induced hepatocellular carcinoma using RNA-sequencing analysis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Profiling; Gene Expression R | 2019 |
Hepatoprotective effect of boldine against diethylnitrosamine-induced hepatocarcinogenesis in wistar rats.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Apoptosis; Aporphines; bcl-2-Associated X Protein; Carcin | 2019 |
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diet | 2019 |
Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice.
Topics: Animals; Artemisia; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; | 2020 |
Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carcinogenesis; Carcinoma, Hepatocellu | 2020 |
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
Topics: Aldehyde Dehydrogenase; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; delt | 2020 |
Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cyclin D1; Diethyln | 2019 |
Overexpression of Hepatocyte Chemerin-156 Lowers Tumor Burden in a Murine Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Chemokines; Cholesterol; Diethylnitrosamine; Diglycerides; Disea | 2019 |
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced | 2020 |
Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 2; Diethyln | 2020 |
Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosa | 2020 |
Combretastatin A-4 disodium phosphate and low dose gamma irradiation suppress hepatocellular carcinoma by downregulating ROCK1 and VEGF gene expression.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chemoradiotherapy; Combined M | 2020 |
Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Caseins; Diet, Vegetarian; Diethylnitrosamine; F | 2020 |
Administration of Steamed and Freeze-Dried Mature Silkworm Larval Powder Prevents Hepatic Fibrosis and Hepatocellular Carcinogenesis by Blocking TGF-β/STAT3 Signaling Cascades in Rats.
Topics: Animals; Bombyx; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; | 2020 |
MicroRNA-195 vector influence on the development of gradually induced hepatocellular carcinoma in murine model.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Liver N | 2020 |
The potential chemotherapeutic effect of β-ionone and/or sorafenib against hepatocellular carcinoma via its antioxidant effect, PPAR-γ, FOXO-1, Ki-67, Bax, and Bcl-2 signaling pathways.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Ce | 2020 |
Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma.
Topics: Aminocoumarins; Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Death; | 2020 |
The role of bone marrow-derived cells in the origin of liver cancer revealed by single-cell sequencing.
Topics: Animals; Biomarkers, Tumor; Bone Marrow Cells; Bone Marrow Transplantation; Carcinoma, Hepatocellula | 2020 |
Method for Structural Determination of Lipid-Derived Radicals.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Free Radicals; Injections, Intraperitoneal; Lip | 2020 |
Differential changes in the pharmacokinetics of doxorubicin in diethylnitrosamine-induced hepatocarcinoma model rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Doxorubicin; Liver Neoplasms; Rats | 2020 |
Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Hepatocellular; CRISPR-Cas Systems; D | 2020 |
Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Calcium Channel Blockers; Carcinoma, Hepatocellular | 2020 |
STAT3 and AKT signaling pathways mediate oncogenic role of NRSF in hepatocellular carcinoma.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethylnitros | 2020 |
Time serial transcriptome reveals
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cytochrome P450 Family 2; | 2020 |
Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Animals; Carcinoma, Hepatocellular; Coenzyme A Ligases; Diet, | 2020 |
A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2020 |
Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Diethyln | 2020 |
UDP-glucuronosyltransferase polymorphisms affect diethylnitrosamine-induced carcinogenesis in humanized transgenic mice.
Topics: Animals; Biopsy; Carcinogenesis; Diethylnitrosamine; Disease Models, Animal; Enzyme Activation; Fema | 2020 |
[Inhibitory effect of
Topics: Animals; Aspartate Aminotransferases; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Rats; Rats, | 2020 |
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.
Topics: Adult; Aged; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferatio | 2021 |
Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance.
Topics: Animals; Antineoplastic Agents; Cancer-Associated Fibroblasts; Carcinoma, Hepatocellular; Coculture | 2021 |
Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Diethylnitr | 2021 |
Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Catechin; cdc25 Phosphatases; | 2020 |
Low-polar extract from seed of Cleistocalyx nervosum var. paniala modulates initiation and promotion stages of chemically-induced carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Proliferation; Cell Transformation, Neoplastic; Co | 2021 |
Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosa | 2021 |
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Def | 2020 |
Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Inflammation; Limonins; Live | 2020 |
Romidepsin hepatocellular carcinoma suppression in mice is associated with deregulated gene expression of bone morphogenetic protein and Notch signaling pathway components.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Carcinoma, Hepatocellular; Cell | 2021 |
Dietary modulations of folic acid affect the development of diethylnitrosamine induced hepatocellular carcinoma in a rat model.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Folic Acid; Liver; Liver Cirrhosis; Liver Ne | 2021 |
Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosa | 2021 |
Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; | 2021 |
Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks.
Topics: Androgens; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; | 2021 |
Correlation between inflammatory cytokines and liver cancer stem cell markers in DEN-induced liver cancer rats.
Topics: Administration, Oral; Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Chemokine CCL2; Die | 2021 |
Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Bi | 2021 |
Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carcinoma, Hepa | 2021 |
Mitochondria-targeted antioxidant, mito-TEMPO mitigates initiation phase of N-Nitrosodiethylamine-induced hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Diethylnitrosamine; Lipid Peroxidation; Liver; Liver Neoplasms; | 2021 |
Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline Deficiency; Cyclin-De | 2021 |
Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice.
Topics: Animals; Biomarkers, Tumor; Cell Death; Chromosomal Instability; Diethylnitrosamine; Disease Suscept | 2021 |
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocel | 2021 |
Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethyln | 2021 |
Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinoma, Hepatocellular; Diethylnitro | 2021 |
Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Shape; Chemical and Drug Induced Liver | 2021 |
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Animals; Arginine; Carcinogenesis; Carcinoma, Hep | 2021 |
Therapeutic Role of Bone Marrow-Derived Mesenchymal Stem Cells in Controlling Prognosis of Hepatocellular Carcinoma in a Murine Model.
Topics: Animals; Bone Marrow; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Humans; | 2022 |
Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats.
Topics: 1,2-Dimethylhydrazine; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carcin | 2021 |
Multi-stress accelerated liver cancer progression in rats treated with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Rats | 2021 |
Periostin deficiency reduces diethylnitrosamine-induced liver cancer in mice by decreasing hepatic stellate cell activation and cancer cell proliferation.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Proliferation; Diethy | 2021 |
The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; Din | 2022 |
Chemopreventive Effect of
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Clusiaceae | 2021 |
Rhubarb granule promotes diethylnitrosamine-induced liver tumorigenesis by activating the oxidative branch of pentose phosphate pathway via G6PD in rats.
Topics: Animals; Biomarkers; Diethylnitrosamine; Gene Expression Regulation, Enzymologic; Glucosephosphate D | 2021 |
Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression.
Topics: Albendazole; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Biological Availability; Carci | 2021 |
Vidatox 30 CH has tumor activating effect in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line; Cell Line | 2017 |
Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cholesterol; Diethylnitrosamine | 2017 |
CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression.
Topics: Animals; Aurora Kinase B; Biological Transport; Carcinogens; Carcinoma, Hepatocellular; Cell Nucleus | 2018 |
Modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes, cell proliferation, apoptosis, invasion and angiogenesis during NDEA-induced rat hepatocarcinogenesis.
Topics: Animals; Apoptosis; Benzofurans; Cell Proliferation; Cell Transformation, Neoplastic; Diethylnitrosa | 2017 |
Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Emboliz | 2017 |
Thiamine potentiates chemoprotective effects of ibuprofen in DEN induced hepatic cancer via alteration of oxidative stress and inflammatory mechanism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cytokines; Diethylnitrosa | 2017 |
FXR-Gankyrin axis is involved in development of pediatric liver cancer.
Topics: Animals; CELF1 Protein; Cell Differentiation; Cell Line, Tumor; Diethylnitrosamine; Gene Expression | 2017 |
Tg737 regulates epithelial-mesenchymal transition and cancer stem cell properties via a negative feedback circuit between Snail and HNF4α during liver stem cell malignant transformation.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Cell Transformation, N | 2017 |
RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.
Topics: Aging; Animals; Carcinogenesis; CELF1 Protein; Child; Diethylnitrosamine; Disease Models, Animal; E2 | 2017 |
Chronic Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis via Immune Disturbances.
Topics: Alcohol Drinking; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Pr | 2017 |
Chitosan nanoparticles from marine squid protect liver cells against N-diethylnitrosoamine-induced hepatocellular carcinoma.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Chitosan; Decapodiformes; Diethylnitrosamine; Lipi | 2017 |
Triterpenoids principle of Wedelia calendulacea attenuated diethynitrosamine-induced hepatocellular carcinoma via down-regulating oxidative stress, inflammation and pathology via NF-kB pathway.
Topics: Animals; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Diethylnit | 2018 |
Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study.
Topics: alpha-Fetoproteins; Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosa | 2017 |
MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholesterol; Diethylnitrosamine; Down-Regulati | 2017 |
Role of insulin receptor substrates in the progression of hepatocellular carcinoma.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progre | 2017 |
An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease M | 2018 |
Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation, Ne | 2017 |
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Topics: ADAM17 Protein; Albumins; Animals; ATP Binding Cassette Transporter, Subfamily B; Carcinogenesis; Ca | 2017 |
Umbelliferon-α-d-glucopyranosyl-(2
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Proliferation; Cytok | 2017 |
Nelumbo nucifera leaf extract treatment attenuated preneoplastic lesions and oxidative stress in the livers of diethylnitrosamine-treated rats.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Aspartate Aminotrans | 2017 |
Gamma-irradiated β-glucan modulates signaling molecular targets of hepatocellular carcinoma in rats.
Topics: Animals; beta-Glucans; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gamma | 2017 |
Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosami | 2017 |
Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Blotting, Western; Carcinoma, Hepatocellul | 2017 |
Sequential analysis and staging of a diethylnitrosamine-induced hepatocellular carcinoma in male Wistar albino rat model.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Lipids; | 2017 |
Dioxin Receptor Adjusts Liver Regeneration After Acute Toxic Injury and Protects Against Liver Carcinogenesis.
Topics: Animals; Biomarkers; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Diethy | 2017 |
Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Apolipoprotein A-I; Biomarkers, Tumor; Carcinom | 2018 |
In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biomarkers, Tumor; Body Weight; Carcinoma, Hepatocellu | 2017 |
Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; | 2017 |
Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclin D1; Diethylnitrosamine; | 2017 |
Voluntary Wheel Running Reduces the Acute Inflammatory Response to Liver Carcinogen in a Sex-specific Manner.
Topics: Acute Disease; Animals; Carcinogens; Carcinoma, Hepatocellular; Choice Behavior; Diethylnitrosamine; | 2017 |
Identification of (Z)-2,3-Diphenylacrylonitrileas Anti-Cancer Molecule in Persian Gulf Sea Cucumber Holothuria parva.
Topics: 2-Acetylaminofluorene; Acrylonitrile; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chr | 2017 |
Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; | 2018 |
Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Administration, Intravenous; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Pro | 2017 |
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Gen | 2017 |
The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cell Proliferation; | 2018 |
Molecular characterization of the grape seeds extract's effect against chemically induced liver cancer: In vivo and in vitro analyses.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Cycle Checkpoin | 2018 |
The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepato | 2018 |
Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 | 2018 |
In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver; Li | 2018 |
Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytokines; Diet, High-Fat; Diethylnitrosamin | 2018 |
Hepatocyte Wnts Are Dispensable During Diethylnitrosamine and Carbon Tetrachloride-Induced Injury and Hepatocellular Cancer.
Topics: Animals; beta Catenin; Cadherins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamin | 2018 |
β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin.
Topics: AC133 Antigen; Animals; beta Catenin; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tu | 2018 |
The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
Topics: Aged; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cohort St | 2019 |
WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diet, High-Fat; Diethylnit | 2018 |
HCC Specific Protein Network Involving Interactions of EGFR with A-Raf and Transthyretin: Experimental Analysis and Computational Biology Correlates.
Topics: Animals; Carcinoma, Hepatocellular; Computational Biology; Diethylnitrosamine; Dose-Response Relatio | 2018 |
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
Topics: Animals; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholangiocarcinoma; Chole | 2018 |
Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosam | 2018 |
Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death, compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activation.
Topics: Animals; Carcinoma, Hepatocellular; Caspase 3; Cell Death; Cell Proliferation; Cell Transformation, | 2018 |
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosa | 2018 |
Resistive Part of Impedance as a Possible Indicator of Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Electric Impedance; Liver; Liver Neoplasms; | 2018 |
Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Me | 2018 |
Correlation between HSD17B4 expression in rat liver cancer tissues and inflammation or proliferation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Estradiol; Extracellular | 2018 |
From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor.
Topics: Adult; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Diethylnitrosami | 2018 |
Investigation of PD-1H in DEN-induced mouse liver cancer model.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Disease Models, Animal; Humans; Liver Neoplasms; Mal | 2018 |
Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Move | 2018 |
Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways.
Topics: 5-Methoxypsoralen; Animals; Body Weight; Carcinogenesis; Diethylnitrosamine; Gene Expression Regulat | 2018 |
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an | 2019 |
Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles.
Topics: Animals; Antioxidants; Apocynaceae; Biomarkers, Tumor; Diethylnitrosamine; Down-Regulation; Female; | 2018 |
Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice.
Topics: Age of Onset; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Female; Hi | 2018 |
Elevated Expression of A-Raf and FA2H in Hepatocellular Carcinoma is Associated with Lipid Metabolism Dysregulation and Cancer Progression.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Lipid Metabolism; Liver Neoplasms; M | 2019 |
The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransfera | 2018 |
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High- | 2019 |
Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression via miR-145/miR-21 mediated Smad3 phosphorylation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Astragalus Plant; Carcinoma, Hepatocellular; Diethylnitr | 2019 |
Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes.
Topics: Animals; beta-Carotene 15,15'-Monooxygenase; Carcinoma, Hepatocellular; Carotenoids; Diet, High-Fat; | 2018 |
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcino | 2018 |
Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats.
Topics: Angiotensin Receptor Antagonists; Animals; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cell Tr | 2018 |
Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation
Topics: Animals; Biological Availability; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Compounding; F | 2018 |
Dextrose modified bilosomes for peroral delivery: improved therapeutic potential and stability of silymarin in diethylnitrosamine-induced hepatic carcinoma in rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Survival; Diet | 2019 |
The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways.
Topics: Adult; Aged; Aged, 80 and over; Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Di | 2018 |
WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Chromosom | 2019 |
Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens.
Topics: Animals; Cadherins; Carbon Tetrachloride; Cell Proliferation; Cell Transformation, Neoplastic; Dieth | 2019 |
Identification of the Potential Metabolic Pathways Involved in the Hepatic Tumorigenesis of Rat Diethylnitrosamine-Induced Hepatocellular Carcinoma via
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose; Glutamic Acid; Glut | 2019 |
Extracts of Qizhu decoction inhibit hepatitis and hepatocellular carcinoma in vitro and in C57BL/6 mice by suppressing NF-κB signaling.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herba | 2019 |
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Pro | 2019 |
Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; Disease Models, A | 2019 |
Functional characterization of anti-cancer sphingolipids from the marine crab Dromia dehanni.
Topics: Animals; Antineoplastic Agents; Brachyura; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnit | 2019 |
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Topics: alpha-Fetoproteins; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2019 |
Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice.
Topics: Alkylating Agents; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Cyclic N-Oxides | 2019 |
NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Mod | 2019 |
Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 2019 |
Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs.
Topics: Animals; Biomarkers, Tumor; Diethylnitrosamine; Disease Models, Animal; Hemangiosarcoma; Liver Neopl | 2019 |
Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Carcinoma, Hepatocellular; Diabetes Mellitus, Experimen | 2019 |
Sex hormone-binding globulin suppresses NAFLD-triggered hepatocarcinogenesis after menopause.
Topics: Acetyl-CoA Carboxylase; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diet, High-Fat; Diethyln | 2019 |
Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Drug Syn | 2019 |
B-mode ultrasound for the assessment of hepatic fibrosis: a quantitative multiparametric analysis for a radiomics approach.
Topics: Animals; Biopsy; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatic Veins; Humans; | 2019 |
Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study.
Topics: Acute-Phase Proteins; Adolescent; Adult; Aged; Animals; Biomarkers; Blood Proteins; Carcinogens; Car | 2019 |
GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; Down-R | 2019 |
Dual-Targeted Lactoferrin Shell-Oily Core Nanocapsules for Synergistic Targeted/Herbal Therapy of Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disaccharides; Drug Delivery Systems; Gene E | 2019 |
Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Progression; Fatty L | 2019 |
An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Contro | 2019 |
Telmisartan attenuates N-nitrosodiethylamine-induced hepatocellular carcinoma in mice by modulating the NF-κB-TAK1-ERK1/2 axis in the context of PPARγ agonistic activity.
Topics: Animals; Antihypertensive Agents; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferati | 2019 |
Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats.
Topics: Animals; Antioxidants; Autophagy; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation | 2013 |
Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspartate Aminotransf | 2013 |
Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicates SEC63 as potential target gene in hepatocarcinogenesis.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Animals; Apoptosis; Carcinoma, Hepa | 2013 |
Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.
Topics: Animals; Base Sequence; CCAAT-Enhancer-Binding Protein-beta; Cell Proliferation; Diethylnitrosamine; | 2013 |
Cyclin E facilitates dysplastic hepatocytes to bypass G1/S checkpoint in hepatocarcinogenesis.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neoplastic; | 2013 |
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.
Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; | 2013 |
Promyelocytic leukaemia protein links DNA damage response and repair to hepatitis B virus-related hepatocarcinogenesis.
Topics: Adiposity; Animals; Antibiotics, Antineoplastic; Biomarkers; Biopsy; Carcinoma, Hepatocellular; Cell | 2013 |
Liver tumor promoting effect of orphenadrine in rats and its possible mechanism of action including CAR activation and oxidative stress.
Topics: Animals; Cell Nucleus; Cholinergic Antagonists; Constitutive Androstane Receptor; Diethylnitrosamine | 2013 |
Enhanced liver tumor promotion activity in rats subjected to combined administration of phenobarbital and orphenadrine.
Topics: Animals; Cytochrome P-450 CYP2B1; Diethylnitrosamine; Drug Combinations; Drug Synergism; Enzyme Indu | 2013 |
Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.
Topics: 5-Methylcytosine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosine; | 2013 |
Mitochondria protection with ginkgolide B-loaded polymeric nanocapsules prevents diethylnitrosamine-induced hepatocarcinoma in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Ginkgolides; Lacton | 2014 |
LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis.
Topics: Animals; Cell Line; Cytokines; Diethylnitrosamine; Gene Deletion; Humans; LIM-Homeodomain Proteins; | 2013 |
Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethy | 2013 |
Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells.
Topics: Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chemok | 2013 |
Real-time diagnosis of chemically induced hepatocellular carcinoma using a novel mass spectrometry-based technique.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Liver Neoplasms; Male; Mice; Mice, I | 2013 |
Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53.
Topics: Animals; Biopsy; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Etoposide; G | 2014 |
Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.
Topics: 2-Aminopurine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; | 2013 |
Expansion of hepatic stem cell compartment boosts liver regeneration.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Different | 2014 |
Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Berberine; Blotting, Western; Carbon T | 2014 |
Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats.
Topics: Animals; Apoptosis; Arsenicals; Aryl Hydrocarbon Hydroxylases; bcl-2-Associated X Protein; Body Weig | 2013 |
Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP1A1; Depression, Chemica | 2013 |
Anticancer potential of rhamnocitrin 4'-β-D-galactopyranoside against N-diethylnitrosamine-induced hepatocellular carcinoma in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Aspartate Aminotransferases | 2013 |
Two-stage model of chemically induced hepatocellular carcinoma in mouse.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferat | 2013 |
Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Carotenoids; Ce | 2013 |
Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse.
Topics: Acetylcysteine; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line; Diethyl | 2013 |
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepa | 2013 |
Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure.
Topics: Alkylating Agents; Animals; Axl Receptor Tyrosine Kinase; Carcinoma, Hepatocellular; cdc25 Phosphata | 2013 |
Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances.
Topics: Animals; Blotting, Western; Carcinogenesis; Cell Line, Tumor; Chromatin Immunoprecipitation; Chromat | 2013 |
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas | 2014 |
Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription.
Topics: Animals; Astragalus Plant; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation | 2014 |
Lipid droplet binding thalidomide analogs activate endoplasmic reticulum stress and suppress hepatocellular carcinoma in a chemically induced transgenic mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Pro | 2013 |
Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antineoplastic Agents; Antirheumatic Agents; Carc | 2014 |
Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine-induced hepatocarcinogenesis in mice.
Topics: Animals; Cell Transformation, Neoplastic; Chromatin; Diethylnitrosamine; Gene Expression Profiling; | 2014 |
Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis.
Topics: Animals; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinoma, | 2014 |
Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; L | 2013 |
Compound Astragalus and Salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-β/Smad signaling.
Topics: Animals; Astragalus Plant; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship | 2014 |
CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model.
Topics: Active Transport, Cell Nucleus; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Nucleus; Di | 2013 |
Decorin deficiency promotes hepatic carcinogenesis.
Topics: Animals; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Cyclin-Dependent Kinase Inhib | 2014 |
Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Syst | 2014 |
Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cellular Microenvir | 2014 |
Viral-human chimeric transcript predisposes risk to liver cancer development and progression.
Topics: Animals; Base Sequence; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Di | 2014 |
Possible role of selective, irreversible, proteasome inhibitor (carfilzomib) in the treatment of rat hepatocellular carcinoma.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Endostatins; | 2014 |
Cancer chemopreventive effect of Spirogyra neglecta (Hassall) Kützing on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Transformation, Neoplastic; Chemoprevention; Dieth | 2014 |
High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Dietary Carbohydrates; Dietary Fats; Die | 2014 |
Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bili | 2014 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul | 2014 |
Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice.
Topics: Alcoholic Beverages; Animals; Carcinoma, Hepatocellular; China; Diethylnitrosamine; Disease Models, | 2014 |
Azadirachta indica modulates electrical properties and type of cell death in NDEA-induced hepatic tumors.
Topics: Animals; Apoptosis; Azadirachta; Diethylnitrosamine; Electrophysiological Phenomena; Liver Neoplasms | 2014 |
Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease M | 2014 |
Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carcinogenesis; Ca | 2014 |
Cytokeratin 7/19 expression in N-diethylnitrosamine-induced mouse hepatocellular lesions: implications for histogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regu | 2014 |
In vivo evaluation of Eclipta alba extract as anticancer and multidrug resistance reversal agent.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Antineoplastic Agents, Phytogenic; Aspartate A | 2014 |
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cell T | 2014 |
Formylchromone exhibits salubrious effects against nitrosodiethylamine mediated early hepatocellular carcinogenesis in rats.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Ch | 2014 |
Dynamic analysis of tumor-associated immune cells in DEN-induced rat hepatocellular carcinoma.
Topics: Animals; B-Lymphocytes, Regulatory; Bone Marrow Cells; Carcinogens; Carcinoma, Hepatocellular; Cells | 2014 |
Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats.
Topics: Aldehyde Reductase; Alkylating Agents; Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers; Carc | 2014 |
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Diethylnitrosamine; ErbB Rec | 2014 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Binding Sites; Carcinoma, Hepatocellular; Cell Pr | 2014 |
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2014 |
Synthesis and discovery of 18α-GAMG as anticancer agent in vitro and in vivo via down expression of protein p65.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Diethylnitrosamine; Drug Discovery; Fe | 2014 |
Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling.
Topics: Animals; Apoptosis; Cell Proliferation; Diethylnitrosamine; Glutathione S-Transferase pi; Immunohist | 2014 |
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Basigin; Carcinogens; Carcinoma, H | 2015 |
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Damage; Gene Expression Regulation, Neop | 2014 |
Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitr | 2015 |
C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis.
Topics: Amino Acid Sequence; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitro | 2015 |
MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Flavonoi | 2015 |
Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progression; Endocannabinoids; Forkh | 2015 |
The important role of ADAM8 in the progression of hepatocellular carcinoma induced by diethylnitrosamine in mice.
Topics: ADAM Proteins; Alanine Transaminase; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Antigens, | 2015 |
Mouse models of liver cancer.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Hepatoprotective effects of curcumin against diethyl nitrosamine induced hepatotoxicity in albino rats.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Carcinoma, Hepatocellular; Catalase; Chemical and Drug In | 2015 |
A Schiff base derivative for effective treatment of diethylnitrosamine-induced liver cancer in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cisplatin; Coordination Complexes; Copper; Diethylnitrosa | 2015 |
Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regu | 2015 |
Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chromatography, Liquid; Diethylnitrosamine; D | 2015 |
Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1 channels as potential early-stage markers of HCC.
Topics: Animals; Apoptosis; Astemizole; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; Di | 2015 |
TGF-β regulates hepatocellular carcinoma progression by inducing Treg cell polarization.
Topics: Animals; Azabicyclo Compounds; Carcinoma, Hepatocellular; Cell Differentiation; Cell Polarity; Cell | 2015 |
Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice.
Topics: Adipokines; Animals; Animals, Newborn; Carcinogenesis; Diabetes Mellitus, Experimental; Diethylnitro | 2015 |
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel | 2015 |
Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-β/Smad signaling in hepatocellular carcinoma by multi-target mechanism.
Topics: Alkenes; Animals; Astragalus propinquus; Carcinoma, Hepatocellular; Diethylnitrosamine; Down-Regulat | 2015 |
Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway.
Topics: Allyl Compounds; alpha-Fetoproteins; Animals; Carcinoma; Cyclooxygenase 2; Diethylnitrosamine; I-kap | 2015 |
Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice.
Topics: Animals; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolif | 2015 |
The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cysteine-R | 2016 |
Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate.
Topics: Animals; Carcinoma, Hepatocellular; Catechin; Cell Membrane Permeability; Copper; Diethylnitrosamine | 2015 |
β-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling.
Topics: Alkylating Agents; Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Blotting, W | 2015 |
Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.
Topics: Aging; Amino Acid Sequence; Animals; Animals, Genetically Modified; Carcinogenesis; Carcinoma, Hepat | 2015 |
Essential role of constitutive androstane receptor in Ginkgo biloba extract induced liver hypertrophy and hepatocarcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cocarcinogenesis; Constitu | 2015 |
Implications of Sex Hormone Receptor Gene Expression in the Predominance of Hepatocellular Carcinoma in Males: Role of Natural Products.
Topics: Animals; Biological Products; Carcinoma, Hepatocellular; Curcumin; Cymenes; Diethylnitrosamine; Down | 2015 |
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chemical and | 2015 |
p53-p66(shc)/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Carbon Tetrachloride; Carcinoma, Hepatoc | 2015 |
Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.
Topics: Animals; Apoptosis Regulatory Proteins; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamin | 2015 |
MiR-17-92 cluster promotes hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease | 2015 |
Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzodioxoles; Carcin | 2015 |
Fourier Transform Infrared Spectroscopic Studies on Modulation of N-Nitrosodiethylamine-Induced Hepatocarcinogenesis by Azadirachta indica.
Topics: Alkylating Agents; Animals; Azadirachta; Carcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; | 2015 |
Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Feasibility Studies; Fluorodeoxyglucose F18; | 2015 |
Induction of Liver Tumors in Mice with N-Ethyl-N-Nitrosourea or N-Nitrosodiethylamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; Ethylnitrosourea; Injections, Intraperitoneal; Liver Neopl | 2015 |
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Escherichia | 2015 |
Interleukin-17A Plays a Pivotal Role in Chemically Induced Hepatocellular Carcinoma in Mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Deoxyguanosine; | 2016 |
Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis.
Topics: Age Factors; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Diethylnitrosamine; ErbB | 2015 |
Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients.
Topics: alpha-Fetoproteins; Animals; Betaine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cohort Studies; | 2015 |
Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats.
Topics: Adenylate Kinase; Animals; Blotting, Western; Body Weight; Carcinogenesis; Carcinoma, Hepatocellular | 2016 |
Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; DNA-Binding Prote | 2015 |
Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine.
Topics: Animals; beta-Galactosidase; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell Proliferation; Cel | 2016 |
Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carbon Tetrachloride; | 2016 |
Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chemokine CCL2; Cytokines; Diethylnitrosa | 2015 |
Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Comet Assay; Cyclo | 2015 |
Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis.
Topics: Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Cholic Acid; Cyclin D1; Diethylnitrosamine; | 2016 |
Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Diethylnitrosamine; Disease Models, Animal; eIF-2 | 2016 |
Dietary Broccoli Lessens Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and Fed a Western or Control Diet.
Topics: Alanine Transaminase; Animals; Brassica; Carcinoma, Hepatocellular; Diet, Western; Diethylnitrosamin | 2016 |
Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.
Topics: Alginates; Animals; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Diethylnitrosa | 2016 |
CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus-positive patients with resected hepatocellular carcinoma.
Topics: Aged; Aged, 80 and over; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; | 2016 |
Myricetin Selectively Induces Apoptosis on Cancerous Hepatocytes by Directly Targeting Their Mitochondria.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Apop | 2016 |
Dietary sugar intake increases liver tumor incidence in female mice.
Topics: Adiposity; Animal Feed; Animals; Body Weight; Carcinogens; Dietary Fats; Dietary Sucrose; Diethylnit | 2016 |
Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cell Transformation, Neoplastic | 2016 |
Soy Protein Isolate Protects Against Ethanol-Mediated Tumor Progression in Diethylnitrosamine-Treated Male Mice.
Topics: Adenoma; Alkylating Agents; Animals; Blotting, Western; Carcinoma, Hepatocellular; Diet; Diethylnitr | 2016 |
Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice.
Topics: Animals; Apoptosis; beta Catenin; Biflavonoids; Body Weight; Carcinogenesis; Catechin; Cell Prolifer | 2016 |
Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; | 2016 |
Correlation between angiogenic/inflammatory mediators in Wister rat model of liver dysplasia.
Topics: Animals; Cyclooxygenase 2; Diethylnitrosamine; Disease Models, Animal; Enzyme-Linked Immunosorbent A | 2016 |
Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms.
Topics: Animals; Antineoplastic Agents; bcl-2-Associated X Protein; bcl-X Protein; Carcinogenesis; Carcinoma | 2016 |
Brief Communication: Featured Article: Histone H2A mono-ubiquitination and cellular transformation are inversely related in N-nitrosodiethylamine-induced hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neopl | 2016 |
Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carcinogenesis; Carcinoma, Hepatocellular; Ce | 2016 |
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Survival; Diethylnitrosamine; Gene Expression Regulation, N | 2016 |
Role of the BrafV637E mutation in hepatocarcinogenesis induced by treatment with diethylnitrosamine in neonatal B6C3F1 mice.
Topics: Animals; Carcinogenesis; Cell Cycle; Cytokines; Diethylnitrosamine; Female; Gene Expression Regulati | 2017 |
Fluorescence probes to detect lipid-derived radicals.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Apoptosis; Cell Line, Tumor; Cyclic N-Oxides; Diethylnitrosam | 2016 |
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine.
Topics: Animals; Biomarkers; Body Weight; Carcinoma, Hepatocellular; Choline Deficiency; Diet, High-Fat; Die | 2016 |
LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.
Topics: Animals; Carcinogenesis; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Glutaminase; Gl | 2016 |
The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Diethylnitrosamine; Disease Models, Animal; D | 2017 |
Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model.
Topics: Angiography; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease Models, | 2017 |
Clock gene Per2 as a controller of liver carcinogenesis.
Topics: Animals; Carcinogenesis; Circadian Rhythm; Diethylnitrosamine; Interleukin-6; Liver; Liver Neoplasms | 2016 |
Caspase-2 deficiency accelerates chemically induced liver cancer in mice.
Topics: Animals; Carcinoma, Hepatocellular; Caspase 2; Cell Death; Cell Proliferation; Diethylnitrosamine; D | 2016 |
Photothermal therapy mediated by gum Arabic-conjugated gold nanoparticles suppresses liver preneoplastic lesions in mice.
Topics: Animals; Apoptosis; Cell Survival; Cell Transformation, Neoplastic; Diethylnitrosamine; Glutathione | 2016 |
Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
Topics: Animals; Autophagy; Carcinogenesis; Carcinoma, Hepatocellular; Death-Associated Protein Kinases; Die | 2016 |
Evaluation of antioxidant and stabilizing lipid peroxidation nature of Solanum xanthocarpum leaves in experimentally diethylnitrosamine induced hepatocellular carcinogenesis.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Body Weight; Carcinogenesis; Diethylnitrosamine; Lipid Per | 2016 |
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode | 2017 |
The dark side of "the force" - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice.
Topics: Animals; Carcinogenesis; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Humans; Lip | 2017 |
Biochemical and molecular evidences for the antitumor potential of Ginkgo biloba leaves extract in rodents.
Topics: Anaplasia; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation; Ginkg | 2017 |
Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
Topics: Aging; Alanine Transaminase; Aminobiphenyl Compounds; Animals; Animals, Newborn; Carbon Tetrachlorid | 2016 |
Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma.
Topics: Animals; beta-Arrestin 2; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement | 2016 |
Enhancement of DEN-induced liver tumorigenesis in heme oxygenase-1 G143H mutant transgenic mice.
Topics: Animals; Carcinogenesis; Carcinogens; Diethylnitrosamine; Heme Oxygenase-1; Liver Neoplasms; Membran | 2016 |
CAMK2γ antagonizes mTORC1 activation during hepatocarcinogenesis.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carcinogenesis; Cell Death; Cell Line, | 2017 |
Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles.
Topics: Animals; Carcinoma, Hepatocellular; Carotenoids; Cell Proliferation; Diethylnitrosamine; Drug Delive | 2017 |
Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice.
Topics: Animals; Apoptosis; Cell Line, Tumor; Diethylnitrosamine; ErbB Receptors; Humans; Liver Neoplasms; M | 2016 |
Effect of Chokeberry Juice on N-Nitrosodiethylamine-Induced Rat Liver Carcinogenesis.
Topics: Animals; Carcinogenesis; Carcinogens; Diethylnitrosamine; Fruit and Vegetable Juices; Liver; Liver N | 2016 |
A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Diethylnitros | 2016 |
DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; Geneti | 2017 |
miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver.
Topics: Animals; Calpain; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethylnitrosamine; | 2017 |
Actein ameliorates hepatobiliary cancer through stemness and p53 signaling regulation.
Topics: AC133 Antigen; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Cell Proliferation; Cyclin D | 2017 |
The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents, Immunological; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proli | 2017 |
Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.
Topics: Animals; beta Catenin; beta Karyopherins; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line | 2017 |
Absence of Malat1 does not prevent DEN-induced hepatocarcinoma in mice.
Topics: Animals; Blood Glucose; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Deletion; Gene Expressio | 2017 |
Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1.
Topics: Administration, Oral; Animals; Body Weight; Cell Proliferation; Chenodeoxycholic Acid; Diethylnitros | 2017 |
Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Topics: Acetyl-CoA Carboxylase; Alkylating Agents; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatoc | 2017 |
Quantum mechanical model for the anticarcinogenic effect of extremely-low-frequency electromagnetic fields on early chemical hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Disease Models, Animal; | 2017 |
Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice.
Topics: Actins; Animals; Antigens, Nuclear; Aurora Kinase A; Aurora Kinases; Carcinogens; Carcinoma, Hepatoc | 2008 |
Reduction by dietary matrix metalloproteinase inhibitor BAY 12-9566N of neoplastic development induced by diethylnitrosamine, N-nitrosodimethylamine, or 7,12-dimethylbenz(a)anthracene in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Antineoplastic Agents; Biphenyl Compounds; Carci | 2008 |
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.
Topics: Animals; Antioxidants; Carcinogens; Cell Death; Cell Proliferation; Diethylnitrosamine; Enzyme Activ | 2008 |
Vesicular flavonoid in combating diethylnitrosamine induced hepatocarcinoma in rat model.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catalase; Diethylnit | 2008 |
Promoting effect of o-aminoazotoluene on hepatocarcinogenesis is accompanied by the increase in inflammatory and proliferative processes in liver tissue and decrease in the concentration of free thyroxin in the blood.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Female; Inf | 2007 |
Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques.
Topics: Animals; beta Catenin; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosa | 2008 |
Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice.
Topics: Animals; Body Weight; Carcinogenicity Tests; Diethylnitrosamine; Disease Models, Animal; Fenofibrate | 2008 |
Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats.
Topics: Animals; Carcinogens; Diet; Dietary Fats; Diethylnitrosamine; Fatty Liver; Glutathione S-Transferase | 2009 |
Impact of insulin resistance on the progression of chronic liver diseases.
Topics: Animals; Cell Proliferation; Chronic Disease; Collagen; Diethylnitrosamine; Disease Progression; Glu | 2008 |
Protective action of indole-3-acetic acid on induced hepatocarcinoma in mice.
Topics: Alanine Transaminase; Alkylating Agents; Animals; Antioxidants; Aspartate Aminotransferases; Diethyl | 2009 |
Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met.
Topics: Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Glutamate-Ammonia Ligase; Liver; Liver Neoplasms | 2009 |
Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase.
Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamin | 2009 |
[The expression of B-cell translocation gene 2 in diethylnitrosamine-induced primary hepatocellular carcinoma rat model.].
Topics: Animals; B-Lymphocytes; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatocytes; Liver Neoplasms; | 2009 |
Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Carnitine; Catalase; Dietary Supplem | 2009 |
Measuring microenvironment mechanical stress of rat liver during diethylnitrosamine induced hepatocarcinogenesis by atomic force microscope.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver; Liver Neoplasms; Microsc | 2009 |
The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Blotting, Western; Carcinoma, Hepatocellular; | 2009 |
The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors.
Topics: Animals; Apoptosis; Cell Cycle; Cell Transformation, Neoplastic; Constitutive Androstane Receptor; D | 2009 |
Effect of antisense oligomer in controlling c-raf.1 overexpression during diethylnitrosamine-induced hepatocarcinogenesis in rat.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Transformation, Neoplastic; Cytochrome P-45 | 2010 |
Effect of selenium-enriched malt on hypoglycemia and regulatory hormones in diethylnitrosamine-induced hepatocarcinoma SD rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Edible Grain; Hypoglycemia; Liver Neoplasms; | 2009 |
Absence of chemopreventive influence of propolis on the rat liver altered foci development.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Brazil; Cocarcinogenesis; Diethylnitrosamine; Glutath | 2010 |
Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model.
Topics: Alkylating Agents; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Disease Progression; Gene Ex | 2009 |
Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model.
Topics: Animals; Betaine; Cyclin-Dependent Kinase Inhibitor p16; Diethylnitrosamine; DNA Methylation; Dose-R | 2009 |
N-Nitrosopiperidine and N-Nitrosodibutylamine induce apoptosis in HepG2 cells via the caspase dependent pathway.
Topics: Alkylating Agents; Apoptosis; Blotting, Western; Carcinogens; Caspases; Cell Survival; Diethylnitros | 2009 |
Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Cyclin D1; Diethylnitrosamine; DN | 2010 |
Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Caspase 3; Ce | 2010 |
The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Genes, Tumor Suppressor; Liver Neoplasms; Male; Mi | 2010 |
BRE over-expression promotes growth of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Humans; Liver; Liver Neo | 2010 |
Evaluation of the protective effect of ascorbic acid on nitrite- and nitrosamine-induced cytotoxicity and genotoxicity in human hepatoma line.
Topics: Antioxidants; Ascorbic Acid; Carcinoma, Hepatocellular; Cell Survival; Comet Assay; Cytoprotection; | 2010 |
Inhibition by licorice flavonoid oil of glutathione S-transferase-positive foci in the medium-term rat hepatocarcinogenesis bioassay.
Topics: Animals; Antineoplastic Agents, Phytogenic; Diethylnitrosamine; Flavonoids; Functional Food; Glutath | 2010 |
The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; D | 2010 |
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Extracellular Signal-Reg | 2010 |
The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Profiling; Gene Expression R | 2010 |
Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Chemoprevention; Cyclooxygenase 2; Diethylnitrosamine; Female; HSP | 2010 |
Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin.
Topics: Animals; beta Catenin; Diethylnitrosamine; Hepatocytes; Liver Neoplasms; Liver Regeneration; Male; M | 2010 |
Quantitative multiparametric PROPELLER MRI of diethylnitrosamine-induced hepatocarcinogenesis in wister rat model.
Topics: Algorithms; Animals; Diethylnitrosamine; Disease Models, Animal; Humans; Image Enhancement; Image In | 2010 |
Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet).
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Carc | 2010 |
Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Base Sequence; Carcinoma, Hepatocellu | 2010 |
Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling.
Topics: Acetylcysteine; Administration, Oral; Animals; Apoptosis; beta Catenin; Carcinoma, Hepatocellular; C | 2010 |
Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; | 2010 |
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
Topics: Aging; Animals; Dietary Fats; Diethylnitrosamine; DNA Damage; Female; Glucose Tolerance Test; Liver | 2010 |
Tumor formation in liver of conditional β-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen.
Topics: Animals; beta Catenin; Carcinogens; Diethylnitrosamine; DNA Mutational Analysis; Immunohistochemistr | 2011 |
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Topics: Animals; Anthocyanins; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Prolifer | 2011 |
Aberrant expression of the p53-inducible antiproliferative gene BTG2 in hepatocellular carcinoma is associated with overexpression of the cell cycle-related proteins.
Topics: Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, | 2011 |
Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis.
Topics: Aging; Animals; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin E; Cyclooxy | 2011 |
Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Diabetes Mellitus, Experimental; D | 2011 |
Of mice and men: the nonrandom genomic instability in hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Genes, myc; | 2011 |
Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carcinoma, Hepatocellular; Comparative Genomic Hybridization; Core Binding Fa | 2011 |
Polyol profile as an early diagnostic and prognostic marker in natural product chemoprevention of hepatocellular carcinoma in diabetic rats.
Topics: Aldehyde Reductase; Allyl Compounds; alpha-Fetoproteins; Animals; Ascorbic Acid; Blood Glucose; Carc | 2011 |
Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell | 2011 |
In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury, Chronic; Concanavalin A; Diethylnitr | 2011 |
Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Cyclophosphamide; Die | 2011 |
Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carcinoma, Hepatocellular; | 2011 |
Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Ca | 2011 |
Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation, Neo | 2011 |
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Gene Express | 2011 |
Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice.
Topics: Alkylating Agents; Animals; Cell Proliferation; Cytoglobin; Diethylnitrosamine; Dose-Response Relati | 2011 |
PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biopsy, Needle; Blotting, W | 2011 |
Non-invasive monitoring of hepatocellular carcinoma in transgenic mouse with bioluminescent imaging.
Topics: alpha-Fetoproteins; Animals; Animals, Newborn; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethyln | 2011 |
Potential chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis in rats: myrrh (Commiphora molmol) vs. turmeric (Curcuma longa).
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Curcuma; Diet | 2012 |
Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; DNA Pr | 2012 |
Normal hepatocyte transplantation delays the emergence of chemically induced preneoplastic nodules in rat liver.
Topics: Animals; Cells, Cultured; Diethylnitrosamine; Hepatocytes; Immunohistochemistry; Liver; Liver Neopla | 2012 |
Azadirachta indica exhibits chemopreventive action against hepatic cancer: Studies on associated histopathological and ultrastructural changes.
Topics: Animals; Antineoplastic Agents; Azadirachta; Carcinogens; Chemoprevention; Diethylnitrosamine; Disea | 2012 |
N-nitrosodiethylamine genotoxicity evaluation: a cytochrome P450 induction study in rat hepatocytes.
Topics: Alkylating Agents; Animals; Apoptosis; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P- | 2011 |
Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Autophagy; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA Brea | 2011 |
Activity of tumor necrosis factor-α blocked by phytoglycoprotein (38 kDa) at initiation stage in N-nitrosodiethylamine-induced ICR mice.
Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Catalase; Diethyl | 2012 |
Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma.
Topics: Adult; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line, Tumor; Cell Proliferatio | 2012 |
Correlation between liver cancer occurrence and gene expression profiles in rat liver tissue.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Disease Progression; Gene Expression Profiling; | 2011 |
Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; b | 2012 |
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer.
Topics: Adaptive Immunity; Animals; B-Lymphocytes; Biomarkers; Carcinogens; Carcinoma, Hepatocellular; Chemo | 2012 |
Preventive effect of caffeine and curcumin on hepato-carcinogenesis in diethylnitrosamine-induced rats.
Topics: Animals; Anticarcinogenic Agents; Caffeine; Carcinoma, Hepatocellular; Curcumin; Diethylnitrosamine; | 2012 |
PET/CT imaging of c-Myc transgenic mice identifies the genotoxic N-nitroso-diethylamine as carcinogen in a short-term cancer bioassay.
Topics: Animals; Carcinogens; Cell Proliferation; Diagnostic Imaging; Diethylnitrosamine; Glucose; Liver Neo | 2012 |
Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.
Topics: Aneuploidy; Animals; Carcinogens; Cell Cycle Proteins; Cell Line; Chromatids; Chromosomal Proteins, | 2012 |
Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; gamma-Glutamyltransferas | 2012 |
Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing.
Topics: Analysis of Variance; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal | 2012 |
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; D | 2012 |
Efficient enrichment of hepatic cancer stem-like cells from a primary rat HCC model via a density gradient centrifugation-centered method.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Differentiation; Cell Movement; Cell Proliferat | 2012 |
Gene expression profiles reveal significant differences between rat liver cancer and liver regeneration.
Topics: Animals; Apoptosis; Biomarkers; Blotting, Western; Cell Proliferation; Diethylnitrosamine; Disease P | 2012 |
Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Transformat | 2012 |
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Deletion; Genet | 2012 |
In vivo bioluminescent imaging of α-fetoprotein-producing hepatocellular carcinoma in the diethylnitrosamine-treated mouse using recombinant adenoviral vector.
Topics: Adenoviridae; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitro | 2012 |
Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats.
Topics: alpha-Fetoproteins; Animals; Anticarcinogenic Agents; Carbon Tetrachloride; Carcinoembryonic Antigen | 2012 |
Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Progr | 2013 |
Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; E | 2013 |
Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice.
Topics: Alkylating Agents; Animals; Autophagy; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; C | 2013 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepat | 2012 |
Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethylnitrosamine; Humans; L | 2013 |
Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cell Prolifera | 2014 |
The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamin | 2013 |
Constitutive Notch2 signaling induces hepatic tumors in mice.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cell Differentiat | 2013 |
Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice.
Topics: Animals; Antigens, Nuclear; Apoptosis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; D | 2013 |
Notch2 signaling and undifferentiated liver cancers: evidence of hepatic stem/progenitor cell origin.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylni | 2013 |
Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Nucleus; Diet, High-Fat; Diethylnitrosamine; Fa | 2013 |
Stabilization of mitochondrial and microsomal function of fucoidan from Sargassum plagiophyllum in diethylnitrosamine induced hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Biotransformation; Citric Acid Cycle; Diethylnitrosamine; Liver Neop | 2013 |
Marked inhibition of testosterone biosynthesis by the hepatotoxin nodularin due to apoptosis of Leydig cells.
Topics: Animals; Apoptosis; Bacterial Toxins; Cholesterol; Diethylnitrosamine; Leydig Cells; Liver Neoplasms | 2002 |
1alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes and the development of gamma-glutamyltranspeptidase-positive foci in diethylnitrosamine-initiated and streptozotocin-induced diabetes-promoted hepatocarcinogenesis.
Topics: Animals; Body Weight; Calcitriol; Cytoplasm; Diabetes Mellitus, Experimental; Diethylnitrosamine; En | 2002 |
Diethylnitrosamine induces long-lasting re-expression of insulin-like growth factor II during early stages of liver carcinogenesis in mice.
Topics: Adenoma; Alkylating Agents; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Gene Expr | 2002 |
N-ethyl-N-hydroxyethylnitrosamine (EHEN)-induced renal and hepatocarcinogenesis in the tumor suppressor Tsc2 transgenic rat.
Topics: Animals; Animals, Genetically Modified; Carcinogens; Diethylnitrosamine; Female; Gene Expression Reg | 2002 |
Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control.
Topics: Activins; Adenoma; Alternative Splicing; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell | 2002 |
[Effect of Boschniakia rossica extract on antioxidative activities in rat hepatic preneoplasia induced by diethylnitrosamine].
Topics: Animals; Antioxidants; Diethylnitrosamine; Drugs, Chinese Herbal; Glutathione Peroxidase; Glutathion | 1999 |
High vascular endothelial growth factor (VEGF) expression in chemically-induced hepatic microcancers in mice.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Disease Models, Animal; Endothelial Growth Factors; | 2002 |
A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III (GnT-III) transgenic mice induced by diethylnitrosamine (DEN): identification of haptoglobin as a target molecule of GnT-III.
Topics: Animals; Carbohydrate Sequence; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Electrop | 2002 |
Anticarcinogenic effect and modification of cytochrome P450 2E1 by dietary garlic powder in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Diethylnitrosami | 2002 |
Loss of Igf2 imprinting in monoclonal mouse hepatic tumor cells is not associated with abnormal methylation patterns for the H19, Igf2, and Kvlqt1 differentially methylated regions.
Topics: Animals; Base Sequence; Carcinogens; Diethylnitrosamine; DNA Methylation; DNA, Neoplasm; Genomic Imp | 2003 |
Relationship between the imaging features and pathologic alteration in hepatoma of rats.
Topics: Alkylating Agents; Angiography, Digital Subtraction; Animals; Carcinoma, Hepatocellular; Cell Transp | 2003 |
Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasia.
Topics: Animals; Animals, Newborn; Body Weight; Carcinogens; Diethylnitrosamine; Gene Expression Regulation; | 2003 |
Reduced hepatic tumor incidence in cyclin G1-deficient mice.
Topics: Alkylating Agents; Animals; Cell Division; Cellular Senescence; Cyclin G; Cyclin G1; Cyclins; Diethy | 2003 |
Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay.
Topics: Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens; Chlorobenzenes; Clone Cells; Comp | 2003 |
[Inhibitory effects of tea polyphenols and tea pigments on liver precancerous lesions in rats].
Topics: Animals; Antineoplastic Agents, Phytogenic; Diethylnitrosamine; Flavonoids; Glutathione Transferase; | 1999 |
Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen.
Topics: Acyl Coenzyme A; Acyl-CoA Oxidase; Animals; Biomarkers, Tumor; Blotting, Northern; Carcinoma, Hepato | 2003 |
Prevention of dual promoting effects of pentachlorophenol, an environmental pollutant, on diethylnitrosamine-induced hepato- and cholangiocarcinogenesis in mice by green tea infusion.
Topics: Animals; Cholangiocarcinoma; Diethylnitrosamine; Environmental Pollutants; Liver Neoplasms; Pentachl | 2003 |
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].
Topics: Aging; Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Cyclin-Dependent Kinase In | 2003 |
Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis.
Topics: Animals; Antioxidants; Apoptosis; Carcinogens; cdc25 Phosphatases; Cell Line, Tumor; Chromatography, | 2003 |
Changes in some indices of the synthesis of nitric oxide during the early stages of hepatocarcinogenesis.
Topics: Administration, Oral; Animals; Arginine; Carcinogens; Catalase; Diethylnitrosamine; Lipid Peroxidati | 2003 |
STAT-3 activity in chemically-induced hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Antineoplastic Agents, Hormonal; Blotting, Northe | 2003 |
[On the different effect in lung carcinoma of diethylnitrosamine in hamsters and rats].
Topics: Animals; Diethylnitrosamine; Liver Neoplasms; Lung Neoplasms; Neoplasms, Experimental; Rats | 1962 |
[The histogenesis and cytogenesis of liver carcinoma in the rat due to diethylnitrosamine in the light microscopic picture].
Topics: Animals; Carcinoma, Hepatocellular; Cytogenetics; Diethylnitrosamine; Liver Neoplasms; Microscopy; R | 1962 |
[Liver cancer-inducing effect of diethylnitrosamine after rectal administration in rats].
Topics: Administration, Rectal; Animals; Diethylnitrosamine; Liver Neoplasms; Nitrosamines; Rats | 1963 |
Induction of malignant tumors in the guinea pig by oral administration of diethylnitrosamine.
Topics: Administration, Oral; Diethylnitrosamine; Guinea Pigs; Liver Neoplasms; Lung Neoplasms; Neoplasms; N | 1963 |
[Autoradiographic studies on DNA synthesis during experimental cancerization of liver parenchyma cells in rats after diethylnitrosamine].
Topics: Animals; Autoradiography; Diethylnitrosamine; DNA; DNA Replication; DNA, Neoplasm; Liver Neoplasms; | 1962 |
HISTOLOGICAL AND ENZYMATIC CHANGES IN THE LIVERS OF RATS FED THE HEPATIC CARCINOGEN DIETHYLNITROSAMINE.
Topics: Carboxy-Lyases; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dopa Decarboxylase; Hist | 1963 |
[THE CHANGES IN PROTEIN-RIBONUCLEIC ACID METABOLISM IN LIVER EPITHELIAL CELLS DURING EXPERIMENTAL CANCERIZATION WITH DIETHYLNITROSAMINE].
Topics: Autoradiography; Carcinogens; Cell Nucleus; Diethylnitrosamine; DNA; DNA, Neoplasm; Epithelial Cells | 1963 |
[ON THE MORPHOLOGY OF DIETHYLNITROSAMINE-INDUCED LIVER TUMORS IN MICE AND GUINEA PIGS].
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Guinea Pigs; Hemangioendothelioma; Liver Neo | 1963 |
[CHANGES IN METABOLIC PARAMETERS AND GLYCOLYTIC ENZYME ACTIVITIES DURING THE CANCERIZATION OF RAT LIVERS BY DIETHYLNITROSAMINE].
Topics: Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose-6-Phosp | 1964 |
[THE HEXOKINASE ACTIVITY IN THE MITOCHONDRIA OF THE PRECANCEROUS RAT LIVER AND TRANSPLANTED DIETHYLNITROSAMINE HEPATOMA].
Topics: Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; | 1964 |
[QUANTITATIVE ANALYSIS OF THE CARCINOGENIC EFFECT OF DIETHYLNITROSAMINE].
Topics: Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA; DNA, Neoplasm; Esophageal Neoplasms | 1963 |
[CARCINOMA OF THE PARANASAL SINUSES IN MICE AFTER APPLICATION OF DIETHYLNITROSAMINE DROPS TO THE SKIN OF THE BACK].
Topics: Carcinogens; Diethylnitrosamine; Liver Neoplasms; Mice; Nitrosamines; Paranasal Sinus Neoplasms; Par | 1964 |
EFFECT OF ROUTE OF ADMINISTRATION ON THE CARCINOGENIC ACTION OF DIETHYLNITROSAMINE (N-NITROSODIETHYLAMINE).
Topics: Animals; Bronchial Neoplasms; Carcinogens; Cricetinae; Diethylnitrosamine; Female; Humans; Injection | 1964 |
DIETHYLNITROSAMINE-INDUCED HEPATIC DEGENERATION AND NEOPLASIA IN THE AQUARIUM FISH, BRACHYDANIO RERIO.
Topics: Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Fishes; Hepatitis; | 1965 |
[INDUCTION OF LIVER CANCER IN RABBITS WITH DIETHYLNITROSAMINE].
Topics: Carcinogens; Diethylnitrosamine; Liver Neoplasms; Nitrosamines; Pharmacology; Rabbits; Research; Tox | 1965 |
INDUCTION OF MALIGNANT TUMORS IN THE RABBIT BY ORAL ADMINISTRATION OF DIETHYLNITROSAMINE.
Topics: Administration, Oral; Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Lung Neoplasms; Neo | 1965 |
INDUCTION OF MALIGNANT TUMORS IN VARIOUS STRAINS OF MICE BY ORAL ADMINISTRATION OF N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE.
Topics: Adenocarcinoma; Adenoma; Administration, Oral; Animals; Carcinogens; Diethylnitrosamine; Dimethylnit | 1965 |
[ON ANTIGENIC CHARACTERISTICS OF HEPATOMAS PRODUCED IN RATS WITH N-NITROSODIETHYLAMINE].
Topics: Antigens; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethylamines; Liver Neoplasms; Neoplasms; Ne | 1964 |
[THE TOXIC AND CARCINOGENIC EFFECTS OF DIETHYLNITROSAMINE IN RATS DURING SIMULTANEOUS TREATMENT WITH A LIVER PROTECTIVE AGENT].
Topics: Amino Acids; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Neoplasms; Neoplasms, Experimental; N | 1964 |
[The cancerization of liver parenchymatous cells by diethylnitrosamine in the electron microscopic picture].
Topics: Amines; Diethylnitrosamine; Electrons; Hepatocytes; Liver Neoplasms; Microscopy; Microscopy, Electro | 1962 |
Characterizing the role of MDM2 in diethylnitrosamine induced acute liver damage and development of pre-neoplastic lesions.
Topics: Animals; Blotting, Western; Diethylnitrosamine; Female; In Situ Hybridization; Liver; Liver Neoplasm | 2004 |
TNP-470 inhibits oxidative stress, nitric oxide production and nuclear factor kappa B activation in a rat model of hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Blotting, Western; Body Weight; Carcinoma, Hepatocellular; Cyc | 2003 |
Study on mechanism of multistep hepatotumorigenesis in rat: development of hepatotumorigenesis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carcinogens; Cell Transforma | 2001 |
Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver.
Topics: Amino Acid Substitution; Animals; Base Sequence; Carcinoma, Hepatocellular; Connexins; Diethylnitros | 2004 |
Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes.
Topics: Agouti Signaling Protein; Albumins; Animals; Blood Glucose; Body Weight; Carcinogens; Diabetes Melli | 2004 |
Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apigenin; Diethylnitrosamine; Flavonoids; | 2004 |
Absence of carcinogenic and anticarcinogenic effects of annatto in the rat liver medium-term assay.
Topics: Animals; Anticarcinogenic Agents; Bixaceae; Body Weight; Carcinogens; Carotenoids; Comet Assay; Diet | 2004 |
alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.
Topics: Adenoma; Alkylating Agents; alpha-Macroglobulins; Animals; Anticholesteremic Agents; Biomarkers, Tum | 2004 |
Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.
Topics: Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; Female; Hepatocytes; Kupffer Cells; Liver | 2005 |
Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Chromans; Diethylnitrosamine; Gene Expression; | 2004 |
Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Anticholesteremic Agents; Antioxidants; Carcinoge | 2004 |
Different inhibitory effects in the early and late phase of treatment with KAT-681, a liver-selective thyromimetic, on rat hepatocarcinogenesis induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Carcinogens; Cell P | 2005 |
Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Er | 2005 |
Efficacy of Terminalia arjuna (Roxb.) on N-nitrosodiethylamine induced hepatocellular carcinoma in rats.
Topics: Animals; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethanol; Liver; Liv | 2005 |
Radiomodulatory effect of liposome encapsulated AK-2123 on tumor in mice exposed to hepatocarcinogen.
Topics: Acetylcholinesterase; Animals; Carcinogens; Combined Modality Therapy; Diethylnitrosamine; DNA; Gamm | 2005 |
Effect of proapoptosis protein on hepatocarcinogenesis.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Cell Proliferati | 2005 |
Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats.
Topics: Albinism; Animals; Antioxidants; Apigenin; Body Weight; Carcinogenicity Tests; Diethylnitrosamine; D | 2005 |
Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent.
Topics: Alkyl and Aryl Transferases; Animals; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; | 2005 |
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasm | 2005 |
In vivo detection of metabolic changes by 1H-MRS in the DEN-induced hepatocellular carcinoma in Wistar rat.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, Animal | 2005 |
Suppression of beta-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats.
Topics: Animals; Antioxidants; beta Catenin; Carcinoma, Hepatocellular; Citrus; Coumarins; Cytoskeletal Prot | 2005 |
Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa.
Topics: Animals; Body Weight; Chlorella; Diet; Diethylnitrosamine; Eating; Glutathione Transferase; Immunohi | 2005 |
Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Doxorub | 2005 |
Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model.
Topics: Adenoma; Alkylating Agents; Amaranthaceae; Animals; Diethylnitrosamine; Disease Models, Animal; Fema | 2005 |
Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Cell | 2005 |
[Sodium glutamate on some physiological features and chemically induced hepatocarcinogenesis in neontal period in male mice].
Topics: Alkylating Agents; Animals; Body Size; Diethylnitrosamine; Energy Metabolism; Fats; Female; Food Add | 2005 |
Melatonin modulates the oxidant-antioxidant imbalance during N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Liver Neoplas | 2005 |
Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Antigens, Polyomavirus Transforming; Carcinoma, Hepatocellular; Cell Lin | 2005 |
Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions.
Topics: Alkylating Agents; Animals; Apoptosis; Diethylnitrosamine; Down-Regulation; Female; Gene Expression | 2005 |
Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine.
Topics: Alkylating Agents; Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode | 2005 |
Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chemokine CCL3; Chemokine CCL4; Diethylnitros | 2006 |
Concordance of thresholds for carcinogenicity of N-nitrosodiethylamine.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; DNA Adducts; Dose-Response Relation | 2006 |
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Alkylating Agents; Animals; Carcinogens; Cell Transform | 2006 |
Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats.
Topics: Animals; Antioxidants; Body Weight; Cell Transformation, Neoplastic; Diethylnitrosamine; Lipid Perox | 2006 |
Inactivation of PEMT2 in hepatocytes initiated by DENA in fasted/refed rats.
Topics: Animals; Apoptosis; Choline-Phosphate Cytidylyltransferase; Diethylnitrosamine; Down-Regulation; Fas | 2006 |
High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine.
Topics: Alkylating Agents; Animals; beta-Galactosidase; Carcinogens; Carcinoma, Hepatocellular; Cytomegalovi | 2006 |
Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Enzyme Activation; I-kapp | 2006 |
Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Diethylnitrosamine; DNA Damage; gamma-Glutamyltransfe | 2006 |
Chemopreventive activity of a macrofungus Phellinus rimosus against N-nitrosodiethylamine induced hepatocellular carcinoma in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Fungi | 2006 |
Overexpression of cyclin D1 is associated with elevated levels of MAP kinases, Akt and Pak1 during diethylnitrosamine-induced progressive liver carcinogenesis.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cyclin D1; Diethylnitrosamine; Disease Progression; | 2007 |
Chemoprevention of bicyclol against hepatic preneoplastic lesions.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Transformation, Neoplastic; Chemoprevention | 2006 |
In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, | 2006 |
Effect of Bauhinia racemosa stem bark on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.
Topics: Alanine Transaminase; Alkylating Agents; Animals; Antioxidants; Aspartate Aminotransferases; Bauhini | 2007 |
Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; ATP-Binding Cassette Transporters; Carcinogens; C | 2007 |
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2007 |
Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Adhesion Molecules, Neuronal; Diet | 2007 |
The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinogens; | 2007 |
Comparison of mode of action of four hepatocarcinogens: a model-based approach.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Diethylnitrosamine; Female; Liver Neoplasms | 2007 |
Cell proliferation and hepatocarcinogenesis in rat initiated by diethylnitrosamine and promoted by phenobarbital: potential roles of early DNA damage and liver metallothionein expression.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Carcinogens; Cell Proliferation; Copper; Diethylnitrosa | 2007 |
Effect of Qi-protecting powder (Huqi San) on expression of c-jun, c-fos and c-myc in diethylnitrosamine-mediated hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Models, Ani | 2007 |
Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats.
Topics: Amino Acids; Animal Feed; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; DNA Mutat | 2007 |
Changes in the antioxidant system by TNP-470 in an in vivo model of hepatocarcinoma.
Topics: Angiogenesis Inhibitors; Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cyclohexanes | 2007 |
RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Chromosomal Instability; Diethylnitrosamine; Disease | 2007 |
Inhibition of early preneoplastic events in the rat liver by the somatostatin analog lanreotide.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Liver | 2007 |
Anticarcinogenic effects of hexaamminecobalt(III) chloride in mice initiated with diethylnitrosamine.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Catalase; Cobalt; Diethylnitrosamine; gamma-Glu | 2007 |
Hepatocellular carcinoma and sex.
Topics: Alanine Transaminase; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal | 2007 |
Effects of acetylsalicylic acid and celecoxib on the N-nitrosodiethylamine induced carcinogenesis in rat liver and esophagus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Celecoxib; Dieth | 2007 |
TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis.
Topics: Alkylating Agents; Animals; Bronchitis; Cell Line, Tumor; Cell Transformation, Neoplastic; Chronic D | 2008 |
Sodium selenite enhances glutathione peroxidase activity and DNA strand breaks in hepatoma induced by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Alanine Transaminase; Animals; Body Weight; Carcinoma, Hepatocellular; Comet Assay; Diethylnitrosami | 2008 |
Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cimeti | 2008 |
Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Growth Differe | 2008 |
Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors.
Topics: Animals; Base Sequence; Carcinogens; CpG Islands; Diethylnitrosamine; Disease Models, Animal; Diseas | 2008 |
Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma.
Topics: Animals; Arachidonic Acid; Carcinoma, Hepatocellular; Cholesterol, HDL; Cyclooxygenase 2; Diethylnit | 2008 |
TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin B; | 2008 |
Elevated activity of the oxidative and non-oxidative pentose phosphate pathway in (pre)neoplastic lesions in rat liver.
Topics: Animals; Cell Line, Tumor; Diethylnitrosamine; Enzyme Activation; Glucosephosphate Dehydrogenase; Im | 2008 |
[Ultrastructure of human hepatic carcinomas compared with ultrastructural findings in hepatomas induced by chemical agents in Wistar rats and the golden hamster].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Cricetinae | 1983 |
Induction of gamma-glutamyl transpeptidase activity by dietary phenobarbital in "spontaneous" hepatic tumors of C3H mice.
Topics: Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Liver Neoplasms; Male; Mic | 1980 |
Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Dioxins; Drug Synergism; Female; gamma-Gluta | 1980 |
Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats.
Topics: Adenoma; Animals; Body Weight; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Diet; Diethyln | 1980 |
Short-term in vivo initiation/promotion bioassay for hepatocarcinogens.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Interactions; gamma | 1980 |
Age-, sex-, and strain-dependent differences in the induction of enzyme-altered islands in rat liver by diethylnitrosamine.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; | 1981 |
Early appearance of histochemically altered hepatocyte foci and liver tumors in female rats treated with carcinogens one day after birth.
Topics: Animals; Animals, Newborn; Benzopyrenes; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltran | 1981 |
Glucose-6-phosphate dehydrogenase and gama-glutamyltranspeptidase activities in the liver during chemically induced hepatocarcinogenesis in rats and mice.
Topics: Animals; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver; | 1981 |
[The significance of environmental factors for the cancerogenesis in old age by the model of iatrogenic carcinogenesis (author's transl)].
Topics: Aged; Diethylnitrosamine; Gastrointestinal Diseases; Humans; Liver Neoplasms; Neoplasms; Skin Neopla | 1981 |
Enhancement of hepatocarcinogenesis by sequential administration of chemicals: summation versus promotion effects.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Iron; Li | 1981 |
Comparative tumor initiating activities of N-nitrosomethylbenzylamine and N-nitrosodimethylamine in rat liver.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; gamma-Glutamyltransferase; Hepatectomy; Injec | 1982 |
Occurrence of progressive DNA damage coincident with the appearance of foci of altered hepatocytes.
Topics: Animals; Diethylnitrosamine; DNA; Female; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neopl | 1982 |
Comparison of hepatic carcinogen initiation-promotion systems.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; Epoxide Hydrolases; gamma-Glut | 1982 |
On participation of the autonomic nervous system in the mechanisms of chemical carcinogenesis.
Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; | 1982 |
Polybrominated biphenyls as promoters in experimental hepatocarcinogenesis in rats.
Topics: Acyltransferases; Animals; Biphenyl Compounds; Carcinogens; Diethylnitrosamine; Female; Liver; Liver | 1982 |
Modulation of tumor promotion in liver carcinogenesis.
Topics: Animals; Barbiturates; Carcinogens; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Di | 1983 |
Dose and sex dependent effects of 2-acetylaminofluorene, 3'-methyl-4-dimethylaminoazobenzene and DL-ethionine in induction of gamma-glutamyl transpeptidase-positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; E | 1983 |
Inability of red beet betalain pigments to initiate or promote hepatocarcinogenesis.
Topics: Animals; Betalains; Body Weight; Carcinogens; Diethylnitrosamine; Female; Food Coloring Agents; gamm | 1983 |
Possible role of poly(ADP-ribose) polymerase on the early stage of liver carcinogenesis by diethylnitrosamine in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzamides; Diethylnitrosamine; Dimethyl | 1983 |
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1983 |
Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Topics: Acetaminophen; Adenocarcinoma; Animals; Anisoles; Butylated Hydroxyanisole; Carcinogens; Diethylnitr | 1984 |
Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats.
Topics: Animals; Benzamides; Diethylnitrosamine; DNA Repair; gamma-Glutamyltransferase; Liver; Liver Neoplas | 1984 |
Accelerated regression of carcinogen-induced preneoplastic hepatocyte foci by peroxisome proliferators, BR931, 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio (N-B-hydroxyethyl)acetamide, and di-(2-ethylhexyl)phthalate.
Topics: Animals; Cell Division; Choline Deficiency; Diethylhexyl Phthalate; Diethylnitrosamine; gamma-Glutam | 1984 |
Modification of carcinogenesis by antioxidants and other compounds.
Topics: Acetaminophen; Animals; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Diethylnit | 1984 |
Alterations of markers during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Ethylmorphine-N- | 1984 |
In vivo-in vitro rat liver carcinogenesis: modifications in protein synthesis and ultrastructure.
Topics: Albumins; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Antigens, Neoplasm; Cell Line; Cell Nuc | 1980 |
Presence of alpha-fetoprotein-positive cells in hepatocellular foci and microcarcinomas induced by single injections of diethylnitrosamine in infant mice.
Topics: alpha-Fetoproteins; Animals; Carcinoma; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experi | 1983 |
Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Rel | 1983 |
Guinea-pig alpha 1-fetoprotein: purification, characterization, developmental and hormonal regulation, and behavior in diethylnitrosamine hepatocarcinogenesis.
Topics: alpha-Fetoproteins; Animals; Carbohydrates; Chemical Phenomena; Chemistry; Diethylnitrosamine; Fatty | 1983 |
Nuclear morphology in preneoplastic lesions of rat liver.
Topics: Animals; Cell Nucleus; Cytological Techniques; Diethylnitrosamine; Female; Histocytochemistry; Liver | 1983 |
[Evolution of hyperplastic foci in the rat liver induced by diethylnitrosamine].
Topics: alpha-Fetoproteins; Animals; Diethylnitrosamine; Glutathione Transferase; Hyperplasia; Immunoenzyme | 1984 |
Effects of disulfiram on the metabolism of nitrosodiethylamine during liver carcinogenesis.
Topics: Alkylation; Animals; Biotransformation; Diethylnitrosamine; Disulfiram; DNA; Kidney; Liver; Liver Ne | 1984 |
[Studies on the mechanism of carcinogenesis. V. Differential changes in activities of enzymes involved in ornithine metabolism in early phase of hepatocarcinogenesis induced by diethylnitrosamine].
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Ornithine; Ornit | 1982 |
Sex-dependent promoting effect of polychlorinated biphenyls on enzyme-altered islands induced by diethylnitrosamine in rat liver.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Female; Live | 1982 |
Effect of ethanol on early stages in nitrosamine carcinogenesis in rat liver.
Topics: Adenosine Triphosphatases; Alcoholism; Animals; Carcinogens; Diethylnitrosamine; Female; Humans; Liv | 1983 |
Changes in developmental-specific enzyme activities during experimental hepatocarcinogenesis in the rat in vivo [proceedings].
Topics: Animals; Aspartate Aminotransferases; Cell Differentiation; Diethylnitrosamine; Glucokinase; Glucose | 1980 |
Isolation and culture of adult rat hepatocytes and preneoplastic nodules from diethylnitrosamine treated livers: glucose-6-phosphatase distribution, albumin synthesis and hepatic binding protein activity.
Topics: Albumins; Animals; Asialoglycoprotein Receptor; Carrier Proteins; Cells, Cultured; Diethylnitrosamin | 1980 |
Absence of the ether lipid tumour marker in diethylnitrosamine-induced rat liver cell cancer.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethers; Lipids; Liver; Liver Neoplasms; Male | 1981 |
Role of estrogens as promoters of hepatic neoplasia.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Diethylstilbestrol; Dose-Response Relationsh | 1982 |
Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fibronectins; Glycopr | 1982 |
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachl | 1983 |
[Effects of apomorphine and haloperidol on experimental hepatocarcinogenesis].
Topics: Adenoma; Adenoma, Bile Duct; Animals; Apomorphine; Cell Transformation, Neoplastic; Diethylnitrosami | 1983 |
Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets.
Topics: Adenoma, Bile Duct; Amino Acids; Animals; Bile Duct Neoplasms; Choline Deficiency; Diet; Diethylnitr | 1983 |
A histological study of the promotive effect of diethylstilbestrol on diethylnitrosamine initiated carcinogenesis of liver in rat.
Topics: Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Diethylnitrosamine; Diethylstilbestrol; Female | 1984 |
Effects of temperature and partial hepatectomy on the induction of liver tumors in Oryzias latipes.
Topics: Animals; Diethylnitrosamine; DNA, Neoplasm; Fishes; Hepatectomy; Liver Neoplasms; Liver Transplantat | 1984 |
Characteristics of a fish colony of Poeciliopsis and its use in carcinogenicity studies with 7,12-dimethylbenz[a]anthracene and diethylnitrosamine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diethylnitrosamine; Female; Fishes; Liver Ne | 1984 |
The hepatocarcinogenicity of diethylnitrosamine to rainbow trout and its enhancement by Aroclors 1242 and 1254.
Topics: Administration, Oral; Animals; Aroclors; Carcinogens; Chlorodiphenyl (54% Chlorine); Diethylnitrosam | 1984 |
Correlation between time of partial hepatectomy after a single treatment with diethylnitrosamine and induction of adenosinetriphosphatase-deficient islands in rat liver.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Hepatectomy; Liver Neoplasms; Liver Neoplasm | 1980 |
Carcinogenesis studies on guppies.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Fishes; Liver Neoplasms; Liver Regeneration; Male; | 1984 |
Functional alterations of the endoplasmic reticulum and the detoxification systems during diethyl-nitrosamine carcinogenesis in rat liver.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Endoplasmic | 1984 |
Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice.
Topics: Animals; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosamine; Liver; Liver Neoplasms; Lung; | 1984 |
[Sensitivity of hepatocytes to the effect of factors stimulating and suppressing cell proliferation in hepatocarcinogenesis].
Topics: Animals; Cell Division; Diethylnitrosamine; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; | 1984 |
[Cancer of the esophagus induced in the Wistar rat by ethyl-N-butyl-nitrosamine].
Topics: Animals; Carcinoma; Cheek; Diethylnitrosamine; Esophageal Neoplasms; Female; Liver Neoplasms; Male; | 1984 |
[Establishment of test methods for examining promoters of hepatocarcinogenesis--promoting effects of phenobarbital, butylated hydroxytoluene and barbital].
Topics: Animals; Barbital; Barbiturates; Butylated Hydroxytoluene; Cocarcinogenesis; Diethylnitrosamine; Liv | 1984 |
Relationship of histochemically detectable altered hepatocyte foci to hepatic tumorigenesis.
Topics: Aging; Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Male; Nitrosamin | 1984 |
Initiation-promotion-initiation. Induction of neoplastic foci within islands of precancerous liver cells in the rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Ethylnitrosourea; Female; Hepatectomy; Liver; Li | 1984 |
Inhibitory effect of butylated hydroxyanisole and ethoxyquin on the induction of neoplastic lesions in rat liver after an initial treatment with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Anisoles; Body Weight; Butylated Hydroxyanisole; Carcinogens; Diethylnitrosamine; Drug Inte | 1983 |
Promotive effects of thiobenzamide on liver carcinogenesis.
Topics: Amides; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobar | 1983 |
Changes in activities of glutathione peroxidase and glutathione reductase during chemical hepatocarcinogenesis in the rat.
Topics: Animals; Diethylnitrosamine; Glutathione Peroxidase; Glutathione Reductase; Hydrogen Peroxide; Hyper | 1983 |
Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminant.
Topics: Animals; Body Weight; Diet; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Interactions; Enzyme In | 1983 |
Alterations in carbohydrate metabolizing enzymes induced by hormones during the process of carcinogenesis.
Topics: Animals; Carbohydrate Metabolism; Cell Transformation, Neoplastic; Diethylnitrosamine; Glucosephosph | 1983 |
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopla | 1984 |
Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet.
Topics: Animals; Cell Nucleus; Choline Deficiency; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Live | 1984 |
Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Diethylnitrosamine; DNA; Drug Synergism; Liver Neopl | 1984 |
Carcinogenicity of diethylnitrosamine in newborn, infant, and adult mice.
Topics: Age Factors; Animals; Diethylnitrosamine; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, | 1984 |
Usefulness of the hermaphroditic marine fish, Rivulus marmoratus, in carcinogenicity testing.
Topics: Animals; Carcinogens; Diethylnitrosamine; Fishes; Hermaphroditic Organisms; Liver Neoplasms; Sex Det | 1984 |
Preliminary studies on the usefulness of medaka, Oryzias latipes, embryos in carcinogenicity testing.
Topics: Animals; Carcinogens; Diethylnitrosamine; Fishes; Liver; Liver Neoplasms; Microscopy, Electron; Time | 1984 |
Effects of sequential exposure to aflatoxin B1 and diethylnitrosamine on vascular and stomach tissue and additional target organs in rats.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Diethylnitrosamine; H | 1980 |
Promoting effects of polychlorinated biphenyls (Aroclor 1254) and polychlorinated dibenzofuran-free Aroclor 1254 on diethylnitrosamine-induced tumorigenesis in the rat.
Topics: Animals; Aroclors; Benzofurans; Body Weight; Carcinogens; Chlorodiphenyl (54% Chlorine); Cocarcinoge | 1981 |
Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally.
Topics: Animals; Carcinogens; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Male; Neoplasms, Experi | 1981 |
Chemicals, evolution, and cancer development: Rous-Whipple Award Lecture.
Topics: Adult; Aflatoxin B1; Aflatoxins; Animals; Biological Evolution; Carcinogens; Carcinogens, Environmen | 1982 |
Changes in activities of uridine diphosphate-glucuronyltransferases during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxyanisole; Diethylnitrosamine; Enzyme Induction; Gluc | 1982 |
[Localization of cytochrome P-450PB in the rat liver and primary liver tumors of different histological structure after administration of inductor aroclor 1254].
Topics: Adenocarcinoma; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Di | 1982 |
Failure of glutathione to prevent liver cancer development in rats initiated with diethylnitrosamine in the resistant hepatocyte model.
Topics: Animals; Antineoplastic Agents; Diethylnitrosamine; Drug Resistance; Glutathione; Liver; Liver Neopl | 1983 |
Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Resistance; Liver; Liver Neopl | 1983 |
Properties of the increased glutathione S-transferase A form in rat preneoplastic hepatic lesions induced by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Immunochem | 1983 |
Carcinogenic activity of N-nitrosodiethylamine in snakes.
Topics: Animals; Diethylnitrosamine; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Mouth; Mouth Neoplasm | 1983 |
Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Fluorescein; Fluoresceins; Liver; Liver Circulat | 1983 |
Sequential observations on the appearance of neoplastic lesions in the liver and kidney after treatment with N-ethyl-N-hydroxyethylnitrosamine followed by partial hepatectomy and unilateral nephrectomy.
Topics: Animals; Carcinogens; Diethylnitrosamine; Hepatectomy; Kidney Neoplasms; Liver Neoplasms; Male; Neop | 1983 |
Species specificity in nitrosamine carcinogenesis.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Liver Neoplasms; Lung Neopla | 1983 |
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplas | 1983 |
A liver colony assay for a new hepatocyte phenotype as a step toward purifying new cellular phenotypes that arise during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Anti-Bacterial Agents; Cell Separation; Cells, Cultured; Clone Cells | 1980 |
[Use of radionuclides to study structural differences in mitochondrial and lysosomal membranes of normal and neoplastic cells].
Topics: Animals; Carcinoma, Ehrlich Tumor; Diethylnitrosamine; Gallium Radioisotopes; Indium; Intracellular | 1980 |
Relevance of basophilic foci to promoting effect of sex hormones on hepatocarcinogenesis.
Topics: Animals; Castration; Cocarcinogenesis; Diethylnitrosamine; Female; Gonadal Steroid Hormones; Kinetic | 1982 |
[Protein composition of the endoplasmic reticulum of normal rat liver cells and after exposure to the carcinogen N-nitrosodiethylamine].
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Endoplasmic Reticulum; Liver Neoplasms | 1982 |
[Lipid component of endoplasmic reticulum membranes in rat liver during carcinogenesis induced by nitrosodiethylamine].
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Endoplasmic Reticulum; Lipids; Liver N | 1982 |
Effects of various concentrations of ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) on diethylnitrosamine-induced hepatic tumorigenesis in the rat.
Topics: Animals; Body Weight; Clofibrate; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, | 1982 |
Induction of preneoplastic and neoplastic lesions in rats treated N-nitroso compounds.
Topics: Animals; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relati | 1982 |
Temporal advancement of diethylnitrosamine carcinogenesis in aging mice.
Topics: Aging; Animals; Diethylnitrosamine; Female; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms, Experi | 1981 |
Ultrastructure of spontaneous neoplasms induced by diethylnitrosamine and dieldrin in the C3H mouse.
Topics: Aging; Animals; Body Weight; Dieldrin; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, Inbred | 1980 |
Short term induction of preneoplastic nodules in the rat liver. I. The role of 2-AAF as selecting agent.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Drug; | 1980 |
Hepatic lesions in Lebistes reticulatus induced by N-nitrosodiethylamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Fishes; Liver; Liver Neoplasm | 1980 |
The influence of hepatocarcinogens on the central effects of phenobarbital an D-amphetamine.
Topics: 2-Acetylaminofluorene; Animals; Behavior, Animal; Brain; Dextroamphetamine; Diethylnitrosamine; Live | 1980 |
[Cell proliferation analysis of hyperplastic lesions during the liver carcinogenesis in rats by dietylnitrosamine as studied by 3H-thymidine autoradiography (author's transl)].
Topics: Animals; Autoradiography; Cell Division; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Ma | 1981 |
[Protective effect of cholestyramine in the hepatocarcinogenesis of the rat (author's transl)].
Topics: Animals; Bile Acids and Salts; Cholestyramine Resin; Diethylnitrosamine; Liver Cirrhosis, Experiment | 1981 |
The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Drug Evaluation, Preclinical; Enzyme Induction; | 1980 |
Dose-dependent enhancing effect of phenobarbital on hepatocarcinogenesis initiated by diethylnitrosamine in the rat.
Topics: Animals; Diet; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Synergism; Liver Neoplasms | 1981 |
Promotive effects of ethinyl estradiol in hepatocarcinogenesis initiated by diethylnitrosamine in male rats.
Topics: Animals; Diethylnitrosamine; Drug Synergism; Ethinyl Estradiol; Hyperplasia; Liver Neoplasms; Male; | 1981 |
Inhibitory effect of 4,4'-diaminodiphenylmethane on liver, kidney and bladder carcinogenesis in rats ingesting N-ethyl-N-hydroxyethylnitrosamine or N-butyl-N-(4-hydroxybutyl) nitros-amine.
Topics: Aniline Compounds; Animals; Benzhydryl Compounds; Butylhydroxybutylnitrosamine; Carcinogens; Diethyl | 1981 |
Effect of bolandiol dipropionate (anabiol), an anabolic hormone, on diethylnitrosamine-induced hepatocarcinogenesis in rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Estrenes; Liver Neoplasms; Male; Neoplasms | 1981 |
Some conclusions derived from a liver model for carcinogenesis.
Topics: Animals; Biotransformation; Carcinogens; Diethylnitrosamine; Drug Resistance; Liver; Liver Neoplasms | 1981 |
A light and electron microscopic study of liver and lung tumors induced by a single low dose of diethylnitrosamine (DEN) in C57BLXC3H F1 mice.
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Mice; Mice, Inbred C3H; M | 1981 |
SEM study of adult rat hepatocytes from preneoplastic and hyperplastic foci induced in the liver by diethylnitrosamine.
Topics: Animals; Cell Membrane; Diethylnitrosamine; Disease Models, Animal; Female; Hyperplasia; Liver; Live | 1980 |
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia; | 1980 |
Cytosolic levels and distribution of cadmium, copper and zinc in pretumorous livers from diethylnitrosamine-exposed mice and in non-cancerous kidneys cancer patients.
Topics: Animals; Cadmium; Copper; Cytosol; Diethylnitrosamine; Female; Humans; Kidney; Liver Neoplasms; Male | 1980 |
Cytokeratin patterns of liver carcinomas induced by diethylnitrosamine in monkeys.
Topics: Animals; Antibodies, Monoclonal; Carcinoma, Hepatocellular; Chlorocebus aethiops; Diethylnitrosamine | 1995 |
Hepatocarcinogenesis in BXH recombinant inbred strains of mice: analysis of diverse phenotypic effects of the hepatocarcinogen sensitivity loci.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Disease Susceptibility; Eosinophils; Ethylnitroso | 1995 |
Enhanced hepatocyte colony growth in soft agar after in vivo treatment with a genotoxic carcinogen: a potential assay for hepatocarcinogens?
Topics: Agar; Animals; Carcinogenicity Tests; Carcinoma, Hepatocellular; Cells, Cultured; Contact Inhibition | 1995 |
Effect of dietary fat on diethylnitrosamine induced hepatocarcinogenesis in Wistar rats.
Topics: Animals; Body Weight; Dietary Fats; Diethylnitrosamine; Fatty Acids; Lipid Peroxides; Liver Neoplasm | 1995 |
Demonstration of initiation potential of carcinogens by induction of preneoplastic glutathione S-transferase P-form-positive liver cell foci: possible in vivo assay system for environmental carcinogens.
Topics: Animals; Captan; Carcinogenicity Tests; Carcinogens, Environmental; Cyclohexenes; Diethylnitrosamine | 1993 |
Diethylnitrosamine- and partial hepatectomy-induced decrease in alpha 2u-globulin mRNA level in the rat liver.
Topics: Alpha-Globulins; Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA; G | 1993 |
Expression of actin and desmin in experimentally induced hepatic lesions and neoplasms from medaka (Oryzias latipes).
Topics: Actins; Animals; Cholangiocarcinoma; Desmin; Diethylnitrosamine; Epithelium; Gene Expression; Liver; | 1995 |
Dose-related changes in the profile of ras mutations in chemically induced CD-1 mouse liver tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Carcinogens; Codon; Diethylnitrosamine; DNA, Neo | 1995 |
Induction of minisatellite DNA rearrangements by genotoxic carcinogens in mouse liver tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; DNA | 1995 |
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Caffeine; Coffee; Diethylnitrosamine; | 1995 |
[N-nitroso-compounds of pickles in the areas with high incidence of digestive cancers and their mutagenic effects].
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Food Preservation; Liver Neo | 1994 |
Development of altered hepatocyte foci by separate and combined treatments with radiation and diethylnitrosamine in neonatal rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Female; Gamma Rays; Glutathione Transferase; Liver; Liver | 1994 |
Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azoxymethane; Colonic Neoplasms; Diethylnitrosamine; Digestive Sy | 1995 |
Hepatocarcinogenesis in p53-deficient mice.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Dosage; Genes, p53; Liver Neoplasms; Ma | 1995 |
Number of simultaneously expressed enzyme alterations correlates with progression of N-ethyl-N-hydroxyethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Adenosine Triphosphatases; Animals; Biomarkers; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell D | 1993 |
Constitutive expression of functional P-glycoprotein in rat hepatoma cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Carrier | 1994 |
Dose related promoter effect of metanil yellow on the development of hepatic pre-neoplastic lesions induced by N-nitrosodiethylamine in rats.
Topics: Animals; Azo Compounds; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Food Colo | 1994 |
22-Oxa-1,25(OH)2vitamin D3, a synthetic analogue of vitamin D3, has no promoting activity in a rat liver medium-term bioassay.
Topics: Animals; Antineoplastic Agents; Calcitriol; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Liver | 1994 |
Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms; | 1993 |
Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Transfe | 1993 |
Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age.
Topics: Adenoma, Liver Cell; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Disease Models, Animal; Fe | 1994 |
Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellula | 1994 |
Failure of ozone and nitrogen dioxide to enhance lung tumor development in hamsters.
Topics: Animals; Cricetinae; Diethylnitrosamine; Liver Neoplasms; Lung Neoplasms; Mesocricetus; Nitrogen Dio | 1993 |
Tumor promotion by an anticonvulsant agent, phenytoin, in mouse liver: correlation with CYP2B induction.
Topics: Adenoma; Animals; Body Weight; Carcinogens; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; | 1993 |
Development of hydroxysteroid sulfotransferase-deficient lesions during hepatocarcinogenesis in rats.
Topics: Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Female; Live | 1993 |
Life-span and cancer: the induction time of tumors in diverse animal species treated with nitrosodiethylamine.
Topics: Aging; Animals; Diethylnitrosamine; Life Expectancy; Liver Neoplasms; Neoplasms, Experimental; Speci | 1993 |
Decreased dimethylnitrosamine-induced O6- and N7-methyldeoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Deoxyguanosine; Diethylnitrosam | 1993 |
Three-dimensional analysis of glutathione S-transferase placental form-positive lesion development in early stages of rat hepatocarcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Computer Graphics; Diethylnitrosamine; Glutathione Transfe | 1993 |
Enhancement by non-mutagenic pesticides of GST-P positive hepatic foci development initiated with diethylnitrosamine in the rat.
Topics: Animals; Diethylnitrosamine; Drug Synergism; Glutathione Transferase; Liver; Liver Neoplasms; Male; | 1993 |
Altered foci of hepatocytes in rats initiated with diethylnitrosamine after prolonged fasting.
Topics: Animals; Diethylnitrosamine; Fasting; Immunohistochemistry; Liver; Liver Neoplasms; Male; Rats; Rats | 1993 |
A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis.
Topics: Animals; Body Weight; Diethylnitrosamine; Genetic Linkage; Liver Neoplasms; Liver Neoplasms, Experim | 1993 |
Effect of X rays alone or combined with diethylnitrosamine on tumor induction in infant mouse liver.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Neo | 1993 |
Increased expression of the female-predominant cytochrome P4502C12 in liver nodules from male Wistar rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Female; | 1993 |
Carcinogen-induced diploid hepatocytes: sensitive target cells for transformation by mutated c-Ha-ras oncogene.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Cell Separation; Cell Transformation, Neoplastic; Die | 1993 |
A novel clonality assay for the mouse: application to hepatocellular carcinomas induced with diethylnitrosamine.
Topics: Animals; Base Sequence; Carcinogens; Clone Cells; Diethylnitrosamine; DNA Primers; DNA, Neoplasm; Do | 1996 |
Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Erythrocytes; Female; Hydroxymethylbilane Sy | 1995 |
Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice.
Topics: Animals; Antineoplastic Agents; Cadmium; Carcinoma, Hepatocellular; Diethylnitrosamine; Down-Regulat | 1996 |
Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene.
Topics: Age Factors; Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; DNA, Viral; Dose-Response | 1996 |
Orthotopic liver transplantation for primary hepatic cancer in rats.
Topics: Animals; Autopsy; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Liver Transplantation; Male; Rat | 1996 |
Reversibility of promoter induced hepatic focal lesion growth in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diet; Diethylnitrosamine; Eos | 1996 |
Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; G | 1996 |
Cx32 gene mutation in a chemically induced rat liver tumour.
Topics: Adenoma; Animals; Carcinogens; Connexins; Diethylnitrosamine; Exons; Gap Junction beta-1 Protein; He | 1996 |
No evidence for an inhibitory effect of beta-carotene or of canthaxanthin on the initiation of liver preneoplastic foci by diethylnitrosamine in the rat.
Topics: Animals; Anticarcinogenic Agents; beta Carotene; Canthaxanthin; Carcinogens; Diet; Diethylnitrosamin | 1996 |
Inhibition of aflatoxin B1- and N-nitrosodiethylamine-induced liver preneoplastic foci in rats fed naturally occurring allyl sulfides.
Topics: Aflatoxin B1; Allyl Compounds; Animals; Anticarcinogenic Agents; Diet; Diethylnitrosamine; Disulfide | 1996 |
In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector.
Topics: Adenoviridae; alpha-Fetoproteins; Animals; beta-Galactosidase; Blotting, Southern; Diethylnitrosamin | 1996 |
Diethylnitrosamine exposure-responses for DNA damage, centrilobular cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit some non-linearities.
Topics: Alkylating Agents; Alkylation; Animals; Cell Division; Diethylnitrosamine; DNA Adducts; DNA Damage; | 1996 |
c-myc amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model.
Topics: Adenoma; Animals; Blotting, Northern; Blotting, Southern; Carcinoma, Hepatocellular; Deoxyribonuclea | 1996 |
Selective colocalization of lipid peroxidation and protein thiol loss in chemically induced hepatic preneoplastic lesions: the role of gamma-glutamyltranspeptidase activity.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; gamma-Glutamyltr | 1996 |
Induction of hsp 70 in HepG2 cells in response to hepatotoxicants.
Topics: Bromobenzenes; Cadmium; Carbon Tetrachloride; Carcinogens; Cells, Cultured; Chromatography, Gas; Coc | 1996 |
Dissociation of two actions in the positive effect of prior partial hepatectomy on the induction of the hepatocarcinogenic process by diethylnitrosamine.
Topics: Animals; Carcinogens; Cell Division; Diethylnitrosamine; Female; Hepatectomy; Liver Neoplasms; Liver | 1995 |
Effects of n-tritriacontane-16,18-dione, curcumin, chlorphyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model.
Topics: Aminobiphenyl Compounds; Animals; Antimutagenic Agents; Antineoplastic Agents; Antioxidants; Carcino | 1997 |
Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Colchicine; Diethylnitrosamine; Dose-Response | 1997 |
Enhancing effects of phenobarbital and 3-methylcholanthrene on GST-P-positive liver cell foci development in a new medium-term rat liver bioassay using D-galactosamine.
Topics: Animals; Biological Assay; Blood Chemical Analysis; Body Weight; Carcinogens; Diet; Diethylnitrosami | 1997 |
Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Estrus; Female; Gasoline; Liver Neoplasms; Ma | 1997 |
Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis.
Topics: Aged; Animals; Carcinogens; Carcinoma, Hepatocellular; Carrier Proteins; Cholesterol; Diethylnitrosa | 1997 |
Inhibition by green tea extract of diethylnitrosamine-initiated but not choline-deficient, L-amino acid-defined diet-associated development of putative preneoplastic, glutathione S-transferase placental form-positive lesions in rat liver.
Topics: Alanine Transaminase; Animals; Choline Deficiency; Diet; Diethylnitrosamine; DNA; Glutathione Transf | 1997 |
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; | 1997 |
Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone.
Topics: Adenoma; Animals; Apoptosis; Body Weight; Bromodeoxyuridine; Carcinogens; Diethylnitrosamine; DNA; L | 1997 |
Aryl sulfotransferase IV deficiency in rat liver carcinogenesis initiated with diethylnitrosamine and promoted with N-2-fluorenylacetamide or its C-9-oxidized metabolites.
Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Carcinogens; Diethylnitrosamine; Down-Regulati | 1997 |
Correlation between Bcl-2 expression and histopathology in diethylnitrosamine-induced mouse hepatocellular tumors.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Immunohistochemistry; Liver Neo | 1997 |
Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Carotenoids; Diethylnitrosamine; Liver Neoplasms; Lyc | 1997 |
The effect of fenarimol on marker enzymes in rat liver in two-stages model of hepatocarcinogenesis.
Topics: Alkaline Phosphatase; Animals; Biomarkers, Tumor; Diethylnitrosamine; Disease Models, Animal; Female | 1997 |
Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay.
Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Corticosterone; Diethylnitrosamine; Electromagnet | 1998 |
Chronic liver injury promotes hepatocarcinogenesis of the LEC rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Copper; Dieth | 1998 |
Mechanism of the paradoxical, inhibitory effect of phenobarbital on hepatocarcinogenesis initiated in infant B6C3F1 mice with diethylnitrosamine.
Topics: Adenoma; Animals; Animals, Newborn; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Divi | 1998 |
Differential expression of protein kinase C isoforms in diethylnitrosamine-initiated rat liver.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Isoenzymes; Liver Neoplasms; Protein Kinase C; Pro | 1998 |
Enhanced expression of a new class of liver-enriched b-Zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Carcinogens; Carcinoma, Hepatocellular; Cell Di | 1998 |
Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carotenoids; Chemoprevention; Colonic Neoplasms; Diethy | 1997 |
Differential expression of the polyspecific drug transporter OCT1 in rat hepatocarcinoma cells.
Topics: Animals; Biological Transport; Carcinogens; Carcinoma, Hepatocellular; Carrier Proteins; Diethylnitr | 1998 |
The outcome of liver transplantation at various times (70, 120, and 134 days) after the initiation of carcinogenesis in rats.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Liver N | 1998 |
Suppressive effect of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats.
Topics: alpha-Linolenic Acid; Animals; Anticarcinogenic Agents; Blotting, Northern; Carcinogens; Diethylnitr | 1998 |
Taurine protects the liver against lipid peroxidation and membrane disintegration during rat hepatocarcinogenesis.
Topics: Animals; Carcinogens; Cell Membrane; Diethylnitrosamine; Glucose-6-Phosphatase; Glutathione Peroxida | 1998 |
Tumor recurrence in liver grafts: two animal models.
Topics: Animals; Diethylnitrosamine; Liposarcoma; Liver Neoplasms; Liver Neoplasms, Experimental; Liver Tran | 1998 |
Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Biopsy, Needle; Carcinoma, Hepatocellular; Diethylnitros | 1998 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; | 1998 |
Copper-nitrilotriacetate (Cu-NTA) is a potent inducer of proliferative response both in liver and kidney but is a complete renal carcinogen.
Topics: Animals; Carcinogens; Cell Division; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Male; Mi | 1999 |
Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle; Chick Embryo; Colonic Neopla | 1999 |
Dietary oat lipids-induced novel DNA modifications and suppression of altered hepatic foci formation.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Avena; Carcinogens; Dietary Fats; Diethylnit | 1999 |
Correlation of changes in natural killer cell activity and glutathione S-transferase placental form positive hepatocytes in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Female; Glutathione Transferase; Killer Cells | 1999 |
Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine.
Topics: Adenoma, Bile Duct; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Immunohistoch | 1999 |
Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Chromosome Mapping; Diethylnitrosamine; G | 1999 |
The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains.
Topics: Animals; Carcinogenicity Tests; Connexins; Crosses, Genetic; Diethylnitrosamine; Gap Junction beta-1 | 1999 |
Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Animals; Anti-Infective Agents; Carcinogenicity Tests; Cell Di | 1999 |
Elevation of metallothionein level in preneoplastic lesions during chemical hepatocarcinogenesis of the Fischer 344 rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms; Liver | 1999 |
N-nitrosodiethylamine initiation of carcinogenesis in Japanese medaka (Oryzias latipes): hepatocellular proliferation, toxicity, and neoplastic lesions resulting from short term, low level exposure.
Topics: Age Factors; Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Chemical and Drug Induced L | 1999 |
Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.
Topics: Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Femal | 1999 |
Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators.
Topics: Adenoma; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Gene Expression Regulation, Neoplastic | 1999 |
Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model.
Topics: Animals; Cadherins; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anim | 1999 |
Fas-mediated apoptosis is attenuated in preneoplastic GST-P-positive hepatocytes isolated from diethylnitrosamine-treated rats.
Topics: Animals; Animals, Newborn; Antibodies; Apoptosis; Biomarkers, Tumor; Carcinogens; Cells, Cultured; D | 1999 |
Evaluation of flutamide genotoxicity in rats and in primary human hepatocytes.
Topics: Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Azoxymethane; Colon; Colonic Neoplas | 2000 |
Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma.
Topics: Animals; Carcinogens; Cell Line; Diethylnitrosamine; Disease Models, Animal; Hepatoblastoma; Liver N | 2000 |
Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.
Topics: Adrenocorticotropic Hormone; Alkylating Agents; Animals; Biological Assay; Body Weight; Bromodeoxyur | 2000 |
Enhancement of chemical hepatocarcinogenesis by the HIV-1 tat gene.
Topics: Adenoma, Liver Cell; Animals; Basophils; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; | 2000 |
Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; CDC2 Protein Kinase; Cell Cycle Proteins; Che | 2000 |
Inhibition of chemically induced liver carcinogenesis in Wistar rats by garlic (Allium sativum).
Topics: Animals; Antineoplastic Agents; Diethylnitrosamine; Disease Models, Animal; Garlic; Glutathione Tran | 2000 |
Early exposure to restraint stress enhances chemical carcinogenesis in rat liver.
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Glutathione Transf | 2000 |
Phosphorylation of methylated-DNA-protein-cysteine S-methyltransferase at serine-204 significantly increases its resistance to proteolytic digestion.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Blotting, Western; Calcium; Carcinogens; Diet | 2000 |
Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12.
Topics: Adenoviridae; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Diethylnitrosamine; Geneti | 2001 |
Selective left-lobe atrophy by nodularin treatment accompanied by reduced protein phosphatase 1/2A and increased peroxisome proliferation in rat liver.
Topics: Alkylating Agents; Animals; Apoptosis; Atrophy; bcl-X Protein; Blotting, Western; Carcinogens; Dieth | 2001 |
Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carcinogens; Cytochrome P-4 | 2000 |
Presence of a no-observed effect level for enhancing effects of development of the alpha-isomer of benzene hexachloride (alpha-BHC) on diethylnitrosamine-initiated hepatic foci in rats.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrom | 2001 |
Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; DNA-Binding Prot | 2001 |
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis.
Topics: Administration, Oral; Animals; Body Weight; Calcitriol; Carcinogens; Diethylnitrosamine; Drug Intera | 2000 |
Hypothalamic GABA receptor functional regulation and liver cell proliferation.
Topics: Alkylating Agents; Animals; Cell Division; Chromatography, High Pressure Liquid; Diethylnitrosamine; | 2001 |
Effect of selenium on N-nitrosodiethylamine-induced multistage hepatocarcinogenesis with reference to lipid peroxidation and enzymic antioxidants.
Topics: Alkylating Agents; Animals; Antioxidants; Carcinoma, Hepatocellular; Catalase; Cell Membrane; Diethy | 2001 |
1 alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis.
Topics: Animals; Calcitriol; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship, | 2001 |
Sex hormone dependency of diethylnitrosamine-induced liver tumors in mice and chemoprevention by leuprorelin.
Topics: Animals; Antineoplastic Agents, Hormonal; Body Weight; Crosses, Genetic; Diethylnitrosamine; Estradi | 2001 |
Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice.
Topics: Animals; Blotting, Northern; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Primers; Female; Hum | 2001 |
Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced tumor promotion by 17 beta-estradiol in female Sprague--Dawley rats.
Topics: Animals; Cell Division; Diethylnitrosamine; Estradiol; Female; gamma-Glutamyltransferase; Glutathion | 2001 |
1alpha, 25-Dihydroxyvitamin D3 suppresses the effect of streptozotocin-induced diabetes during chemical rat liver carcinogenesis.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Antioxidants; Blood Glucose; Cytochrome P-450 Enz | 2001 |
Inhibition of chemical carcinogenesis by berberine in rats and mice.
Topics: Alkylating Agents; Animals; Berberine; Cell Transformation, Neoplastic; Diethylnitrosamine; Dose-Res | 2001 |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce | 2001 |
Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carcinogenicity Tests; Carcinoma, Hepatocellular; C | 2001 |
Matrix metalloproteinases-2 and 9 do not play a role in the growth of preneoplastic liver lesions in F344 rats.
Topics: Alkylating Agents; Animals; Densitometry; Diethylnitrosamine; Glutathione Transferase; Liver; Liver | 2001 |
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Topics: Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Carcin | 2001 |
Vitamin A and all-trans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats.
Topics: 2-Acetylaminofluorene; Alitretinoin; Animals; Anticarcinogenic Agents; Bromodeoxyuridine; Carcinogen | 2001 |
Summation of initiation activities in the liver after partial hepatectomy.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Diethylnitrosamine; Dose-Response Relati | 2002 |
Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers.
Topics: Adipose Tissue; Animals; Body Weight; Carcinogens; Constitutive Androstane Receptor; Diethylnitrosam | 2002 |
Nrf2 transactivator-independent GSTP1-1 expression in "GSTP1-1 positive" single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells.
Topics: Animals; Butylated Hydroxyanisole; Diethylnitrosamine; DNA-Binding Proteins; Female; Gene Expression | 2002 |
Effects of N-acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate.
Topics: Acetylcysteine; Animals; Diethylnitrosamine; Ditiocarb; Drug Synergism; Esophageal Neoplasms; Esopha | 2002 |
Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci.
Topics: Alkylating Agents; Animals; Animals, Newborn; Cell Division; Diethylnitrosamine; Female; Gene Expres | 2002 |
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.
Topics: Alkylating Agents; Angiotensin-Converting Enzyme Inhibitors; Animals; Choline; Diethylnitrosamine; D | 2002 |
Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Blotting, Northern; Blotting, Western; Carcinogens; Cattle; Colon; | 2002 |
[Adrenergic component in the hepatotropic, carcinogenic effect of diethylnitrosamine].
Topics: Adrenergic alpha-Antagonists; Animals; Antineoplastic Agents; Carcinogens; Diethylnitrosamine; Dioxa | 1977 |
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Fluorenes; gamm | 1977 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Diethylnitrosam | 1978 |
Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; gamma-Glu | 1978 |
Gamma-glutamyl transpeptidase: a positive marker for cultured rat liver cells derived from putative premalignant and malignant lesions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; Enzyme Induction; | 1978 |
[Modification of chemical carcinogenesis with adrenergic compounds].
Topics: Adrenergic alpha-Antagonists; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Drug Ant | 1978 |
Rapid production of hyperplastic liver nodules in rats treated with carcinogenic chemicals: a new approach for an in vivo short-term screening test for hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; Drug Eva | 1977 |
Flow microfluorometric identification of liver cells with elevated gamma-glutamyltranspeptidase activity after carcinogen exposure.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Diethylnitrosamine; Female; gamma-Glutamyltransferase | 1979 |
Cytologic changes induced in rat livers cells by short-term exposure to chemical substances.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Butanes; Carcinogens; Chromosome Aberrations; DDT; Dieth | 1975 |
Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet.
Topics: Amino Acids; Animals; Body Weight; Carcinoma, Hepatocellular; Choline; Diet; Dietary Fats; Diethylni | 1977 |
In vitro alpha-fetoprotein synthesis by monkey hepatocellular carcinoma.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Haplorhini; In V | 1978 |
Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine | 1975 |
Transaminase level (GOT, GPT) in rats under treatment with diethylnitrosamine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Clinical Enzyme Tests; Diethylnitrosamin | 1975 |
Susceptibility of gerbils (Meriones unguiculatus) to weekly subcutaneous and single intravenous injections of N-diethylnitrosamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Gerbillinae; Injections, Intraveno | 1975 |
Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Disulfiram; Esophageal Neoplasms; Liver Neoplasms; | 1976 |
Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; DNA Nucleotidyltransferases; Do | 1976 |
Variations of liver cell control during diethylnitrosamine carcinogenesis.
Topics: Animals; Circadian Rhythm; Diethylnitrosamine; Growth Inhibitors; Hepatectomy; Liver; Liver Extracts | 1977 |
Hepatocarcinogenetic effect of DENA in pigs.
Topics: Animals; Carcinoma; Diethylnitrosamine; Liver Neoplasms; Neoplasm Metastasis; Neoplasms, Experimenta | 1977 |
The role of nicotinamide and of certain other modifying factors in diethylnitrosamine carcinogenesis: fusaria mycotoxins and "spontaneous" tumors in animals and man.
Topics: Animals; Diethylnitrosamine; Female; Fusarium; Gastrointestinal Neoplasms; Genital Neoplasms, Female | 1977 |
Correlation of liver growth and function during liver regeneration and hepatocarcinogenesis.
Topics: Animals; Cholesterol 7-alpha-Hydroxylase; Diethylnitrosamine; Female; Growth Inhibitors; Hepatectomy | 1979 |
Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression.
Topics: Animals; Antilymphocyte Serum; Carcinoma, Hepatocellular; Diethylnitrosamine; Hydroxyurea; Immunosup | 1975 |
Protective tumor immunity induced by potassium chloride extracts of guinea pig hepatomas.
Topics: Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Diethylnitrosamine; Guinea Pigs; Immunizatio | 1975 |
Effect of a single treatment with the alkylating carcinogens dimethynitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. I. Test for induction of liver carcinomas.
Topics: Adenocarcinoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethylnitrosamine; Female; | 1975 |
[The tumor-tetanus assay--experimental studies on the biological differentiation between carcinogenesis and organ regeneration of the rat (author's transl)].
Topics: Agglutination Tests; Animals; Antibodies, Neoplasm; Antibody Formation; Carcinoma 256, Walker; Carci | 1975 |
The phosphorylation of nuclear proteins in the regenerating and premalignant rat liver and its significance for cell proliferation.
Topics: Animals; Binding Sites; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, Neoplastic; C | 1975 |
Histologic and electron microscopy observations on diethylnitrosamine-induced hepatomas in small aquarium fish (Oryzias latipes).
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Endoplasmic Reticulum; Fishes; Golgi Apparat | 1975 |
[Studies on the influence of anticoagulants on metastase formation of autochthonic hepatomas in the rat (author's transl)].
Topics: Animals; Anticoagulants; Aspirin; Carcinoma, Hepatocellular; Coumarins; Diethylnitrosamine; Female; | 1975 |
Kinetics of induction and growth of precancerous liver-cell foci, and liver tumour formation by diethylnitrosamine in the rat.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Count; Diethylnitrosamine; Dose- | 1975 |
Proceedings: Glucocorticoid receptors and response in diethylnitrosamine-induced hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Dexamethasone; Diethylnitrosamine; Liver Neoplasms; Male; Neopla | 1975 |
[Several properties of the nucleic acide of nuclei and mitochondria from hepatoma induced by N-nitroso-N-diethylamine].
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleus; Diethylnitrosamine; DNA, Neoplasm; Genotype; Liver | 1975 |
Kinetic properties of pyruvate kinase isolated from rat hepatic tumours.
Topics: Adenosine Triphosphate; Alanine; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Kinetics; L | 1976 |
[Study of the mitotic activity during the preneoplastic period in the liver of rats treated by diethylnitrosamine (author's transl)].
Topics: Animals; Circadian Rhythm; Diethylnitrosamine; Liver; Liver Glycogen; Liver Neoplasms; Male; Mitosis | 1976 |
Studies on the terminal stages of antibody-complement-mediated killing of a tumor cell. I. Evidence for the existence of an intermediate, T.
Topics: Animals; Antibodies; Carcinoma, Hepatocellular; Cell Line; Complement System Proteins; Cytotoxicity | 1976 |
Studies on the terminal stages of antibody-complement-mediated killing of a tumor cell. II. Inhibition of transformation of T to dead cells by 3'5' cAMP.
Topics: Animals; Antibodies; Carcinoma, Hepatocellular; Cell Nucleus; Cell Survival; Complement System Prote | 1976 |
Pituitary growth hormone and somatotrophs in rats bearing chemically induced hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Growth Hormone; Liver | 1976 |
Phalloidin tolerance in rats with liver carcinoma induced by diethylnitrosamine.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Tolerance; Lethal Dose 50; Liver Neopla | 1976 |
Composition, associated tissue methyltransferase activity, and catabolic end products of transfer RNA from carcinogen-induced hepatoma and normal monkey livers.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Guanine; Guanosine; Haplorhini; Hypo | 1977 |
Nucleic acids from subcellular fractions of N-nitrosodiethylamine-induced hepatoma in mice.
Topics: Acridines; Animals; Carcinoma, Hepatocellular; Cell Nucleus; Dactinomycin; Diethylnitrosamine; DNA, | 1976 |
Sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose-6-Phospha | 1976 |
[Polyadenylic acid rich RNA fractions in primary hepatomas induced with diethylnitrosamine].
Topics: Animals; Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry; Diethylnitrosamine; Liver Neoplas | 1976 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Synergism; Liver Neoplasms; Male; Neopl | 1976 |
Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver Neoplasms; Lung; Male; Mi | 1977 |
Comparability of histological alterations during carcinogenesis in animals and man, with special reference to hepatocarcinogenesis in fish.
Topics: Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fish Diseases; Humans; H | 1977 |
Altered cobalamin distribution in rat hepatomas and in the livers of rats treated with diethylnitrosamine.
Topics: Animals; Carcinoma, Hepatocellular; Cobamides; Diethylnitrosamine; Female; Liver; Liver Neoplasms; N | 1977 |
The induction of tumors in Rana temporaria with nitrosamines.
Topics: Adenoma; Animals; Anura; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethylnitrosamine; Hematop | 1977 |
Discussion: some comments on the potential carcinogenicity of the clinically useful antitumor agents.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Haplorhi | 1977 |
In vivo initiated rat liver carcinogenesis studied in vitro; formation of alcoholic hyaline-type bodies.
Topics: Animals; Cell Nucleus; Cell Transformation, Neoplastic; Cells, Cultured; Cytoplasm; Diethylnitrosami | 1977 |
Susceptibility to and escape from complement-mediated lysis of guinea-pig hepatoma line-10.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Neoplasm; Carcinoma, Hepatocellular; Cell Line; Chr | 1977 |
Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Haplorhini; Hepati | 1977 |
Hepatic cell loss and proliferation induced by N-2-fluorenylacetamide, diethylnitrosamine, and aflatoxin B1 in relation to hepatoma induction.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosa | 1977 |
Tumor frequency and characteristics after a single dose of dimethylnitrosamine or diethylnitrosamine in partially hepatectomized rats.
Topics: Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethyl | 1977 |
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma].
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hexokinase; Isoenzymes; Liver Neoplasms; Neo | 1978 |
In vitro demonstration of Mallory body formation in liver cells from rats fed diethylnitrosamine.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; In Vitro Techniques; Liver; Liver Ne | 1978 |
Nucleic acids from subcellular fractions of N-nitrosodiethylamine-induced hepatoma in mice. II. Changes in gene expression during tumor progression.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA, Mitochondrial; DNA, Neoplasm; Liver Neo | 1978 |
[Role of hyperplasia in hepatic carcinogenesis].
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Mice; N | 1978 |
Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice.
Topics: Animals; Benzidines; Benzopyrenes; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethylnitrosourea; | 1978 |
Different deviation patterns of carbohydrate-metabolizing enzymes in primary rat hepatomas induced by different chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Cel | 1978 |
[Disorders in the regulation of the activity of microsomal enzymes by lipids during chemical carcinogenesis in the liver].
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Fluorenes; Gluco | 1978 |
The influence of diazepam and thiouracil upon the carcinogenic effect of diethylnitrosamine in gerbils.
Topics: Adenoma, Bile Duct; Animals; Diazepam; Diethylnitrosamine; Gerbillinae; Liver; Liver Neoplasms; Thio | 1978 |
Carcinogenesis of N-nitrosodiethylamine (DENA) in chickens and domestic cats.
Topics: Adenocarcinoma; Administration, Oral; Animals; Animals, Domestic; Carcinogens; Carcinoma, Hepatocell | 1978 |
Guinea pig cell-mediated tumor immunity: the chromium release assay detects both cytolysis and serum blocking for syngeneic chemically-induced tumors.
Topics: Animals; Binding, Competitive; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chromium | 1979 |
Sequential analysis of hepatic carcinogenesis: a comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal, and regenerating liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Membrane; Cell Transformation, Neoplastic; Cytoskeleton; Di | 1979 |
Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Kidney; Kidney Neoplasms; Kidne | 1979 |
Carcinogenicity of methylated derivatives of N-nitrosodiethylamine and related compounds in Sprague-Dawley rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; Esophageal Neoplasms; Female; Liver Neoplasms; Male; Methy | 1979 |
Changes in the labeling index and DNA content of liver cells during diethylnitrosamine-induced liver tumorigenesis in Oryzias latipes.
Topics: Animals; Autoradiography; Diethylnitrosamine; DNA; DNA, Neoplasm; Fishes; Fluorometry; Humans; Liver | 1979 |
Ultrastructural and metabolic determinants of resistance to azo-dye susceptibility to nitrosamine carcinogenesis of the guinea-pig.
Topics: Animals; Diethylnitrosamine; Drug Resistance; Endoplasmic Reticulum; Liver Neoplasms; Male; Mice; Mi | 1977 |
Effect of l-tryptophan on diethylnitrosamine and 3'-methyl-4-n-dimethylaminoazobenzene hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Methyldimethylamin | 1977 |
5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Cytosine; Diethylnitrosamine; Hepatectomy; Liver; Live | 1979 |
[Primary mechanism of a reduction in the intensity of extremely weak mitochondrial luminescence in the process of chemical hepatic carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Catalase; Diethylnitrosamine; Enzyme Activation; Liver Neoplasms; Lu | 1979 |
Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Liver Regenera | 1978 |
[Hepatic RNA resistance to enzymatic degradation in the process of hepatocarcinogenesis in rats].
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experime | 1978 |
Relative carcinogenic effectiveness of derivatives of nitrosodiethylamine in rats.
Topics: Administration, Oral; Animals; Diethylnitrosamine; Esophageal Neoplasms; Liver Neoplasms; Neoplasms, | 1978 |
Liver ornithine decarboxylase during phenobarbital promotion of nitrosamine carcinogenesis.
Topics: Animals; Carboxy-Lyases; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; | 1978 |
Temperature effects during and after the diethylnitrosamine treatment on liver tumorigenesis in the fish, Oryzias latipes.
Topics: Animals; Body Weight; Diethylnitrosamine; Fishes; Japan; Liver Neoplasms; Neoplasms, Experimental; N | 1978 |
Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.
Topics: Acetates; Animals; Cell Division; Clofibrate; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopl | 1978 |
The effect of antilymphocytic and normal horse serum on growth of precancerous foci and development of tumours induced by diethylnitrosamine in rat liver.
Topics: Animals; Antilymphocyte Serum; Diethylnitrosamine; Female; Immunosuppression Therapy; Liver Neoplasm | 1976 |
The behaviour of deoxyribonucleases of rat liver in the course of diethylnitrosamine-induced carcinogenesis.
Topics: Animals; Deoxyribonucleases; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Neoplasms, Experime | 1975 |
[Glycogen and enzymes involved in its biosynthesis in rat liver during liver carcinogenesis caused by diethylnitrosamine].
Topics: Animals; Diethylnitrosamine; Glycogen Synthase; Liver Glycogen; Liver Neoplasms; Neoplasms, Experime | 1976 |
The phosphorylation of histones in rat liver undergoing malignant transformation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Histones; | 1977 |
Effects of nine N-nitroso compounds on the specific radioactivity of liver proteins after injection of [14C]leucine into rats.
Topics: Animals; Cycloleucine; Diethylnitrosamine; Dimethylnitrosamine; Leucine; Liver; Liver Neoplasms; Mal | 1977 |
Multi-hit kinetics of tumor formation, with special reference to experimental liver and human lung carcinogenesis and some gneral conclusions.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dose-Response Relationshi | 1977 |
Newer insights into the pathogenesis of liver cancer.
Topics: Aflatoxins; Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylnit | 1977 |
[Electrophoretic study of the membrane proteins of rat liver endoplasmic reticulum and ribosomes during carcinogenesis induced by diethylnitrosamine].
Topics: Animals; Diethylnitrosamine; Electrophoresis; Endoplasmic Reticulum; Liver Neoplasms; Male; Membrane | 1977 |
Uptake and excretion of 61Cu and 64Cu-myambutol by the liver. Experimental studies in rats and possibilities of a functional liver test in humans.
Topics: Animals; Ceruloplasmin; Copper; Diethylnitrosamine; Ethambutol; Humans; Liver; Liver Diseases; Liver | 1976 |
Combination effects in chemical carcinogenesis (experimental results).
Topics: Animals; Carcinogens; Cocarcinogenesis; Cyclamates; Diethylnitrosamine; Disease Models, Animal; Dose | 1976 |
Diethylnitrosamine-induced changes in mouse liver morphology and function.
Topics: Animals; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Hexobarbital; Liver; Liver Neoplasms; M | 1976 |
Effect of age and sex on lesions of the esophagus in Buffalo strain rats ingesting diethylnitrosamine.
Topics: Age Factors; Animals; Diethylnitrosamine; Esophageal Neoplasms; Female; Liver Neoplasms; Male; Neopl | 1976 |
[Content of polyribosomes and poly-A-containing RNA in rat liver during hepatocarcinogenesis induced by diethylnitrosamine].
Topics: Animals; Chemical Phenomena; Chemistry; Diethylnitrosamine; Liver Neoplasms; Male; Poly A; Polyribos | 1976 |
Carcinogenic effects of a single dose of diethylnitrosamine in three unrelated strains of mice: genetic dependence of the induced tumor types and incidence.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Genotype; Leukemia, Experimental; Liver Neoplasms; | 1976 |
Carcinomas of the esophagus in rats ingesting diethylnitrosamine.
Topics: Administration, Oral; Animals; Bronchopneumonia; Carcinoma; Carcinoma, Squamous Cell; Diethylnitrosa | 1975 |
Effect of diet on DEN clearance and carcinogenesis in rats.
Topics: Animals; Diet; Diethylnitrosamine; Esophageal Neoplasms; Liver Neoplasms; Male; Neoplasms, Experimen | 1975 |
Influence of a chronic administration of diethylnitrosamine on the relation between specific tissular and division functions in the rat liver.
Topics: Animals; Cell Division; Cholesterol 7-alpha-Hydroxylase; Circadian Rhythm; Diethylnitrosamine; Hepat | 1975 |
Lens culinaris lectin receptors in the plasma membrane of rat liver cells: comparative electron microscopic studies on normal cells, on cells in vivo transformed by diethylnitrosamine and on Zajdela ascites hepatoma cells.
Topics: Animals; Antigen-Antibody Complex; Cell Membrane; Diethylnitrosamine; Lectins; Liver; Liver Neoplasm | 1975 |
Concanavalin A receptors on normal rat liver cells, on rat liver cells in vivo transformed by diethylnitrosamine and on Zajdela ascites hepatoma cells of the rat: morphokinetic analysis of cell surface dynamics.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Concanavalin A; Diethylnitrosamine; Liver Neopl | 1975 |
Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine.
Topics: Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Esop | 1976 |
Role of mutations at codon 61 of the c-Ha-ras gene during diethylnitrosamine-induced hepatocarcinogenesis in C3H/He mice.
Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA Mutational Analysis | 1992 |
Characterization of the promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the female rat.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glucose-6 | 1992 |
Diethylnitrosamine-induced increase in gamma-glutamyltranspeptidase in rat liver: its association with thyroid hormone deficiency and its reversal by tri-iodothyronine.
Topics: Aging; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; Precanc | 1992 |
Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1992 |
The insecticide endosulfan and its two stereoisomers promote the growth of altered hepatic foci in rats.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Endosulfan; Hepatectomy; Liver Neoplasms; Mal | 1992 |
Dietary glucarate-mediated inhibition of initiation of diethylnitrosamine-induced hepatocarcinogenesis.
Topics: Animals; Diet; Diethylnitrosamine; Female; Glucaric Acid; Liver; Liver Neoplasms; Rats; Rats, Inbred | 1992 |
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers, Tumor; Cyanobacteria; Diethy | 1992 |
Temporal changes in the mutant frequency and mutation spectra of the 61st codon of the H-ras oncogene following exposure of B6C3F1 mice to N-nitrosodiethylamine (DEN).
Topics: Alleles; Animals; Base Sequence; Codon; Diethylnitrosamine; DNA; Genes, ras; Liver; Liver Neoplasms; | 1992 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cytochrome P- | 1991 |
Initiating activity of diethylnitrosamine in a rapid production model for pancreatic carcinomas in Syrian hamsters.
Topics: Animals; Carcinoma, Intraductal, Noninfiltrating; Cricetinae; Diethylnitrosamine; Female; Hyperplasi | 1991 |
Nuclear topoisomerase I and DNase activities in rat diethylnitrosamine-induced hepatoma, in regenerating and fetal liver.
Topics: Animals; Cations, Divalent; Cell Nucleus; Deoxyribonucleases; Diethylnitrosamine; DNA Topoisomerases | 1991 |
Screen of five alkyl carbamates for initiating and promoting activity in rat liver.
Topics: Animals; Carbamates; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransfera | 1991 |
Comparison of liver cancer and nodules induced in rats by deoxycholic acid diet with or without prior initiation.
Topics: Animals; Cocarcinogenesis; Deoxycholic Acid; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Gl | 1991 |
Enhanced expression of ganglioside GD3 in human and rat hepatocellular carcinoma cells and NIH 3T3 cells transfected with human tumor DNAs.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Carcinoma, Hepatocellular; CD57 Antigens; Cell Lin | 1990 |
Enhanced expression of low molecular weight keratins during progressive diethylnitrosamine-induced hepatocarcinogenesis in rats is associated with the presence of high levels of gamma-glutamyl transpeptidase and glycogen-deficient islands.
Topics: Animals; Biomarkers, Tumor; Cell Differentiation; Diethylnitrosamine; gamma-Glutamyltransferase; Ker | 1991 |
Role of hepatocyte proliferation in alpha-hexachlorocyclohexane and phenobarbital tumor promotion in B6C3F1 mice.
Topics: Animals; Carcinogens; Cell Division; Crosses, Genetic; Diethylnitrosamine; DNA Replication; Female; | 1991 |
Effect of FK 506 on experimental liver carcinogenesis.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver N | 1991 |
Growth kinetics of microscopic hepatocellular neoplasms in carcinogen-resistant and carcinogen-responsive strains of mice.
Topics: Animals; Carcinogens; Cell Division; Diethylnitrosamine; DNA, Neoplasm; Liver Neoplasms; Liver Neopl | 1992 |
[Comparative study on the inhibitory effect of green tea, coffee and levamisole on the hepatocarcinogenic action of diethylnitrosamine].
Topics: Animals; Coffee; Diethylnitrosamine; Levamisole; Liver Neoplasms; Male; Precancerous Conditions; Rat | 1991 |
Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.
Topics: Adenoma; Aflatoxins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Gene Expression | 1991 |
Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepato | 1991 |
Anticarcinogenic effects of cadmium in B6C3F1 mouse liver and lung.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Barbital; Cadmium; Cadmium Chloride; Diethylni | 1991 |
Genetic control of susceptibility to diethylnitrosamine and dimethylbenzanthracene carcinogenesis in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diethylnitrosamine; Female; Genetic Predisposition to Dis | 1991 |
Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis.
Topics: Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Diethylnitrosamine; Drug Synergism; Liv | 1991 |
Specific gain of chromosome 19 in preneoplastic mouse liver cells after diethylnitrosamine treatment.
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Diethylnitrosamine; Karyotyping; | 1991 |
Sex-differentiated deoxycholic acid promotion of rat liver carcinogenesis is under pituitary control.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Deoxycholic Acid; Diethylnit | 1991 |
Expression of a 65-kDa tumor-associated protein and persistence of altered hepatic foci.
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Cell Division; Choline Deficiency; Diethylnitrosamin | 1991 |
Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransfera | 1990 |
Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carbon Tetrachloride; Cell Division; Diethylnitrosa | 1990 |
Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cell Division; Connexins; Diethylnitrosamine; Ethylnitrosou | 1990 |
Lack of modifying effects of p-phenylenediamine on induction of gamma-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Enzyme Induction; gamma-Glutamyltransfe | 1990 |
Ultrastructural changes in chemically induced preneoplastic focal lesions in the rat liver: a stereological study.
Topics: Animals; Animals, Newborn; Biomarkers, Tumor; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1990 |
Antigenic relationship between oval cells and a subpopulation of hepatic foci, nodules, and carcinomas induced by the "resistant hepatocyte" model system.
Topics: Animals; Antibodies, Monoclonal; Antigens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dise | 1991 |
Ultrastructure of hepatic hemangiopericytoma in the medaka (Oryzias latipes).
Topics: Actin Cytoskeleton; Animals; Diethylnitrosamine; Hemangiopericytoma; Liver Neoplasms; Microscopy, El | 1991 |
[Inhibition effect of epicatechin on phenobarbitol-induced proliferation precancerous liver cells].
Topics: Animals; Catechin; Diethylnitrosamine; Flavonoids; Liver Neoplasms; Male; Phenobarbital; Precancerou | 1990 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Dis | 1990 |
Detection of genomic alterations in carcinogen-induced mouse liver tumors by DNA fingerprint analysis.
Topics: Animals; Blotting, Southern; Deoxyribonucleases, Type II Site-Specific; Diethylnitrosamine; DNA Fing | 1990 |
Use of magnetite particles as a contrast agent for MR imaging of the liver.
Topics: Animals; Contrast Media; Diethylnitrosamine; Female; Ferrosoferric Oxide; Image Enhancement; Iron; L | 1990 |
Hepatocellular cancer development in spleen of syngenic rats after transfer of potential precursor hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Glutathione Transferase; Hepatect | 1990 |
Enhanced expression of a 27 kD protein during diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Cadmium; Diethylnitrosamine; Female; Fluorescence; Heat-Shock Proteins; Liver Neoplasms; Me | 1990 |
Cytotoxicity phase of diethylnitrosamine-induced hepatic neoplasia in medaka.
Topics: Animals; Cyprinodontiformes; Diethylnitrosamine; Endoplasmic Reticulum; Glucosephosphate Dehydrogena | 1990 |
Increased silver stainability of metaphase chromosomes from rat hepatocytes during in vivo hepatocarcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Chromosomes; Diethylnitrosamine; Liver Neoplasms; Metaphas | 1985 |
Progression of tumor histiotype during mouse hepatocarcinogenesis associated with the viable yellow (Avy) gene.
Topics: alpha-Fetoproteins; Animals; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Mic | 1986 |
In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver.
Topics: Albumins; alpha-Fetoproteins; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Gene Exp | 1987 |
Discrimination between the nuclear lamin and intermediate filament (cytokeratin/vimentin) proteins of rat hepatic tumor cells by differential solubility and electrophoretic criteria.
Topics: Animals; Cell Line; Cell Nucleus; Diethylnitrosamine; Electrophoresis, Polyacrylamide Gel; Intermedi | 1987 |
Promotion of malignant 'embryonal' liver tumors by phenobarbital: increased incidence and shortened latency of hepatoblastomas in (DBA/2 x C57BL/6)F1 mice initiated with N-nitrosodiethylamine.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Crosses, Genetic; Diethylnitrosamine; Female; Hemang | 1989 |
[Biological activity of hepatocellular carcinoma by analysing nuclear DNA ploidy patterns and using anti BrdU monoclonal antibody].
Topics: Aged; Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Nucleus; D | 1989 |
[A histochemical study of diethylnitrosamine-induced altered liver cells in rats].
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Histocyto | 1989 |
Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations.
Topics: 2-Acetylaminofluorene; Adenoma; Aflatoxin B1; Aflatoxins; Animals; Biomarkers, Tumor; Diethylnitrosa | 1989 |
Activation of a ribosomal S6 protein kinase in rapidly emerging diethylnitrosamine-induced gamma-glutamyltranspeptidase-positive hyperplastic liver lesions of the rat.
Topics: Animals; Diethylnitrosamine; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; gamma-Glutamylt | 1989 |
Tumor phenotype and susceptibility to progression as an expression of subpopulations of initiated murine cells.
Topics: alpha-Fetoproteins; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Susceptibi | 1985 |
A carcinogenesis- and tumorigenesis-associated rat fetal protein: an immuno-histochemical and immuno-biochemical study utilizing a new monoclonal antibody, MOFP.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Biological Assay; Biomarkers, Tumor; Blotting, | 1989 |
Mutations at codon 61 of the Ha-ras proto-oncogene in precancerous liver lesions of the B6C3F1 mouse.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Genes, ras; Liver; Liver Neoplasms; Male; Mice; M | 1989 |
Expression pattern of the genes for different members of the heat-shock protein 70 family, ornithine decarboxylase, and c-Ha-ras during the early stages of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Diethylnitrosamine; Gene Expression Regulation, | 1989 |
Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J mice and F344 rats.
Topics: Adenocarcinoma; Animals; Carcinogens; Diethylnitrosamine; Female; Hemangiosarcoma; Liver Neoplasms; | 1989 |
Fatty acid composition of phospholipids in mitochondria and microsomes during diethylnitrosamine carcinogenesis in rat liver.
Topics: Animals; Cardiolipins; Diethylnitrosamine; Fatty Acids; Hyperplasia; Liver Neoplasms; Liver Neoplasm | 1989 |
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
Topics: Adenoma; Aminopyrine N-Demethylase; Animals; Carcinogens; Carcinoma; Cell Communication; Clonazepam; | 1989 |
Transient induction of single GST-P positive hepatocytes by DEN.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; Glutathione Transfe | 1989 |
Genetic control of susceptibility to diethylnitrosamine carcinogenesis in inbred ACP (grc+) and R16 (grc) rats.
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Major Histocompa | 1989 |
Quantification of nuclear pores in tumor promoter-induced hepatic nodules in rats: a freeze-fracture study.
Topics: Animals; Diethylnitrosamine; Female; Freeze Fracturing; Liver Neoplasms; Nuclear Envelope; Polybromi | 1988 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Dose-dependent promoting activity of chloroform in rat liver foci bioassay.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Chloroform; Cocarcinogenesis; Diethylnitrosamine; F | 1985 |
Synergistic induction of altered hepatocyte foci by combined gamma radiation and diethylnitrosamine administered to neonatal rats.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; Female; Gamma Rays; gamma-Glutamyltransferase; Iron; | 1986 |
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Ne | 1986 |
Continued development of hepatic gamma-glutamyltranspeptidase-positive foci upon withdrawal of 17 alpha-ethynylestradiol in diethylnitrosamine-initiated rats.
Topics: Animals; Diethylnitrosamine; Ethinyl Estradiol; Female; gamma-Glutamyltransferase; Liver; Liver Neop | 1987 |
Complementarity between two rat liver tumor promoters.
Topics: Animals; Choline Deficiency; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neopl | 1987 |
A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Dioxins; D | 1987 |
Molecular dosimetry of DNA alkylation during chronic exposure to carcinogens.
Topics: Alkylation; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA; Dose-Res | 1987 |
[Stimulation, by acute inflammation, of the proliferation in preneoplastic hepatocyte foci expressing the gamma glutamyl transpeptidase, induced by diethylnitrosamine in adult rats].
Topics: Acute Disease; Animals; Caseins; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Infla | 1988 |
Quantitative morphometric comparison between the expression of two different "marker enzymes" in preneoplastic liver lesions induced in rats with low doses of N-nitrosodiethanolamine.
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver Neopla | 1988 |
Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
Topics: Animals; Barbital; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enz | 1989 |
Transplantable chemically-induced liver tumors in the viviparous fish Poeciliopsis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocell | 1985 |
The influence of metabolic liver defects on diethylnitrosamine (NDEA)-carcinogenesis in Gunn rats.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Hemangioendothelioma; Heman | 1985 |
Vascular sarcomas (probably angiosarcomas) transplanted from suspensions of liver cells from diethylnitrosamine-treated rats.
Topics: Alkaline Phosphatase; Animals; Cell Separation; Diethylnitrosamine; Endothelium; Factor VIII; Hemang | 1985 |
Resistance to oxidative stress by hyperplastic and neoplastic rat liver tissue monitored in terms of production of unpolar and medium polar carbonyls.
Topics: Aldehydes; Animals; Arachidonic Acid; Arachidonic Acids; Cell Transformation, Neoplastic; Chromatogr | 1986 |
Possible model of liver carcinogenesis using inhibitors of NAD+ ADP ribosyl transferase in rats.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Male; NAD; Phenobarbita | 1986 |
A new medium-term bioassay system for detection of environmental carcinogens using diethylnitrosamine-initiated rat liver followed by D-galactosamine treatment and partial hepatectomy.
Topics: Animals; Biological Assay; Carcinogens; Diethylnitrosamine; Galactosamine; Glutathione Transferase; | 1988 |
Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Chromatography | 1988 |
Reactivity of monoclonal antibodies to oncoproteins with normal rat liver, carcinogen-induced tumours, and premalignant liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Diethylnitrosamine; Immunoenzyme Techniques; | 1988 |
Increased expression of the N-myc gene during normal and neoplastic rat liver growth.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Female; Kinetics; Liver | 1988 |
Differences in response to a chemical carcinogen within species and clones of the livebearing fish, Poeciliopsis.
Topics: Animals; Cyprinodontiformes; Diethylnitrosamine; Female; Genotype; Liver Neoplasms; Poecilia; Specie | 1988 |
Proliferative response of putative preneoplastic hepatocytes to triiodothyronine, aminoacids, glucagon and heparine.
Topics: Amino Acids; Animals; Cell Division; Diethylnitrosamine; Glucagon; Heparin; Hyperplasia; Liver Neopl | 1988 |
Carcinogenesis and nucleic acid alkylation by some oxygenated nitrosamines in rats and hamsters.
Topics: Administration, Oral; Alkylation; Animals; Cricetinae; Diethylnitrosamine; DNA; Liver Neoplasms; Met | 1988 |
Comparative developmental and phenotypic properties of altered hepatocyte foci and hepatic tumors in rats.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Histocytochemistry; Liver; Li | 1988 |
Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets.
Topics: Animals; Body Weight; Choline; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Liver Neoplasms; | 1986 |
N-nitrosodiethylamine-induced hepatocarcinogenesis in estuarine sheepshead minnow (Cyprinodon variegatus): neoplasms and related lesions compared with mammalian lesions.
Topics: Animals; Bile Ducts; Cyprinidae; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Fish Diseases | 1987 |
Effect of X-rays alone or combined with diethylnitrosamine on cancer induction in mouse liver.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Mice; Neoplasms, Radiat | 1987 |
Expression of retroviral sequences and oncogenes in rat liver tumors induced by diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; ErbB Receptors; Female; Gene Expression Regulation; Genes, Viral; Liver | 1987 |
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver | 1987 |
Influences of diethylnitrosamine on longevity of surrounding hepatocytes and progression of transplanted persistent nodules during phenobarbital promotion of hepatocarcinogenesis.
Topics: Animals; Aroclors; Cell Survival; Chlorodiphenyl (54% Chlorine); Diethylnitrosamine; Female; Liver; | 1987 |
Certain aspects of hepatocarcinogenesis in the infant mouse model.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Female; Liver; Liver Neoplasms; Liver Neoplasms | 1987 |
Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors.
Topics: Adenoma; Aging; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, In | 1987 |
Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats.
Topics: Adenocarcinoma; Animals; Choline; Cocarcinogenesis; DDT; Diethylnitrosamine; Liver Neoplasms; Lung N | 1986 |
Evaluation of the effect of glucan on hepatic, renal and mammary tumorigenesis in rats.
Topics: Animals; Diethylnitrosamine; Female; Glucans; Glucose; Hepatectomy; Kidney Neoplasms; Liver Neoplasm | 1986 |
[Early morphofunctional changes in the liver after administration of nitrosodiethylamine].
Topics: Animals; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Male; Precancerous Conditions; Rat | 1986 |
[Interrelation between the phospholipid composition of rat liver plasma membranes and adenylate cyclase activity in the early stages of liver carcinogenesis induced by nitrosodiethylamine].
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Diethylnitrosamine; Liver Neoplasms; Phospholipids; Rats | 1986 |
[Effect of sodium selenite on the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase) during hepatocarcinogenesis].
Topics: Animals; Diethylnitrosamine; Glutathione Peroxidase; Liver Neoplasms; Rats; Selenious Acid; Selenium | 1986 |
Androgen receptor concentrations in the diethylnitrosamine model of hepatic carcinogenesis.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Female; Liver; Liver Neoplasms; Male; Rats; Rat | 1986 |
Heme enzyme patterns in rat liver nodules and tumors.
Topics: 2-Acetylaminofluorene; 5-Aminolevulinate Synthetase; Animals; Catalase; Chemical and Drug Induced Li | 1987 |
The influence of food intake on the development of diethylnitrosamine-induced liver tumours in mice.
Topics: Animals; Body Weight; Diethylnitrosamine; Energy Intake; Food Deprivation; Liver; Liver Neoplasms; M | 1987 |
Promoting effect of oxazepam in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamin | 1987 |
Changes in nucleolar transcriptional activity and nuclear DNA content during the first steps of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Cell Nucleolus; Diethylnitrosamine; | 1987 |
Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis.
Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Hepatectomy; Lead; Liver Neoplasms | 1987 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
The early growth of cancer.
Topics: Animals; Cell Division; Diethylnitrosamine; Liver Neoplasms; Male; Mathematics; Mice; Models, Biolog | 1985 |
Pathology and tumor development through time in guppies dosed with diethylnitrosamine (DEN).
Topics: Animals; Diethylnitrosamine; Fishes; Liver; Liver Neoplasms; Neoplasms, Experimental; Time Factors; | 1985 |
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; In | 1985 |
Induction of liver tumors in rats by nitrosodiethanolamine at low doses.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Kidney Neoplasms; Liver Neoplasms; Liver Neoplasms | 1985 |