diethylnitrosamine has been researched along with Liver Dysfunction in 27 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 8.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| "We transplanted theanine preincubated adipose-derived stem cells (ADSC) to male Wistar rats with liver dysfunction induced by N-nitrosodiethylamine." | 4.12 | Adipose stem cells preincubated with theanine exert liver regeneration through increase of stem cell paracrine VEGF and suppression of ROS, pyroptosis as well as autophagy markers in liver damage induced by N-nitrosodiethylamine. ( Chen, TS; Chien, CT; Lai, YA; Lai, YJ, 2022) |
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 4.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| "Pitavastatin is effective in inhibiting the early phase of obesity-related liver tumorigenesis and, therefore, may be useful in the chemoprevention of liver cancer in obese individuals." | 3.77 | Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Sakai, H; Shimizu, M; Tanaka, T; Terakura, D; Tsurumi, H; Yasuda, Y, 2011) |
| "Diethylnitrosamine (DEN) was used to induce liver lesions in rats." | 1.33 | [Evaluation of early stage diffused liver lesions with MR functional diffusion-weighted imaging--an experimental study]. ( Cao, G; Guan, S; Mao, J; Peng, WJ; Sun, F; Tang, F; Zhao, WD; Zhou, KR, 2005) |
| "Diethylnitrosamine (DEN) was administered to rats as a single dose, which is known not to give rise to liver tumours without subsequent promotion." | 1.30 | Iron promotes DEN initiated GST-P foci in rat liver. ( Carthew, P; Edwards, RE; Nolan, BM; Smith, AG, 1997) |
| "Diethylnitrosamine (DEN) was administered at the age of 8 weeks." | 1.30 | Chronic liver injury promotes hepatocarcinogenesis of the LEC rat. ( Enomoto, K; Hattori, A; Mori, M; Sawada, N; Sawaki, M; Sugawara, N; Tsuzuki, N, 1998) |
| " Trend tests and a probit dose-response model showed a significantly positive correlation (p = 0." | 1.30 | N-nitrosodiethylamine initiation of carcinogenesis in Japanese medaka (Oryzias latipes): hepatocellular proliferation, toxicity, and neoplastic lesions resulting from short term, low level exposure. ( Brown-Peterson, NJ; Hawkins, WE; Krol, RM; Zhu, Y, 1999) |
| "Diethylnitrosamine (NDEA) was administered subcutaneously to non-icteric and icteric Gunn rats." | 1.27 | The influence of metabolic liver defects on diethylnitrosamine (NDEA)-carcinogenesis in Gunn rats. ( Althoff, J; Fehst, HJ; Mohr, U, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (22.22) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, TS | 1 |
| Lai, YA | 1 |
| Lai, YJ | 1 |
| Chien, CT | 1 |
| Raffaele, M | 1 |
| Kovacovicova, K | 1 |
| Frohlich, J | 1 |
| Lo Re, O | 1 |
| Giallongo, S | 1 |
| Oben, JA | 1 |
| Faldyna, M | 1 |
| Leva, L | 1 |
| Giannone, AG | 1 |
| Cabibi, D | 1 |
| Vinciguerra, M | 1 |
| Wilson, CL | 1 |
| Jurk, D | 1 |
| Fullard, N | 1 |
| Banks, P | 1 |
| Page, A | 1 |
| Luli, S | 1 |
| Elsharkawy, AM | 1 |
| Gieling, RG | 1 |
| Chakraborty, JB | 1 |
| Fox, C | 1 |
| Richardson, C | 1 |
| Callaghan, K | 1 |
| Blair, GE | 1 |
| Fox, N | 1 |
| Lagnado, A | 1 |
| Passos, JF | 1 |
| Moore, AJ | 1 |
| Smith, GR | 1 |
| Tiniakos, DG | 1 |
| Mann, J | 1 |
| Oakley, F | 1 |
| Mann, DA | 1 |
| Park, O | 1 |
| Wang, H | 1 |
| Weng, H | 1 |
| Feigenbaum, L | 1 |
| Li, H | 1 |
| Yin, S | 1 |
| Ki, SH | 1 |
| Yoo, SH | 1 |
| Dooley, S | 1 |
| Wang, FS | 1 |
| Young, HA | 1 |
| Gao, B | 1 |
| Shimizu, M | 1 |
| Yasuda, Y | 1 |
| Sakai, H | 1 |
| Kubota, M | 1 |
| Terakura, D | 1 |
| Baba, A | 1 |
| Ohno, T | 1 |
| Kochi, T | 1 |
| Tsurumi, H | 1 |
| Tanaka, T | 1 |
| Moriwaki, H | 1 |
| Karim, R | 1 |
| Iwai, S | 1 |
| Morimura, K | 1 |
| Wanibuchi, H | 1 |
| Tanaka, R | 1 |
| Matsunaga, S | 1 |
| Yoshitake, A | 1 |
| Fukushima, S | 1 |
| Barbisan, LF | 1 |
| Spinardi-Barbisan, AL | 1 |
| Moreira, EL | 1 |
| Salvadori, DM | 1 |
| Ribeiro, LR | 1 |
| da Eira, AF | 1 |
| de Camargo, JL | 1 |
| Guan, S | 1 |
| Zhao, WD | 1 |
| Zhou, KR | 1 |
| Peng, WJ | 1 |
| Tang, F | 1 |
| Mao, J | 1 |
| Cao, G | 1 |
| Sun, F | 1 |
| Ferencz, V | 1 |
| Horváth, C | 1 |
| Kári, B | 1 |
| Gaál, J | 1 |
| Mészáros, S | 1 |
| Wolf, Z | 1 |
| Hegedus, D | 1 |
| Horváth, A | 1 |
| Folhoffer, A | 1 |
| Szalay, F | 1 |
| Pradeep, K | 1 |
| Mohan, CV | 1 |
| Gobianand, K | 1 |
| Karthikeyan, S | 1 |
| Koul, A | 1 |
| Binepal, G | 1 |
| Gangar, SC | 1 |
| Mazzantini, RP | 1 |
| de Conti, A | 1 |
| Moreno, FS | 1 |
| Schmerold, I | 1 |
| Tempel, K | 1 |
| Imai, T | 1 |
| Masui, T | 1 |
| Ichinose, M | 1 |
| Nakanishi, H | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Muramatsu, M | 1 |
| Tatematsu, M | 2 |
| Carthew, P | 1 |
| Nolan, BM | 1 |
| Smith, AG | 1 |
| Edwards, RE | 1 |
| Sawaki, M | 1 |
| Hattori, A | 1 |
| Tsuzuki, N | 1 |
| Sugawara, N | 1 |
| Enomoto, K | 1 |
| Sawada, N | 1 |
| Mori, M | 1 |
| Sekijima, M | 1 |
| Tsutsumi, T | 1 |
| Yoshida, T | 1 |
| Harada, T | 1 |
| Tashiro, F | 1 |
| Chen, G | 1 |
| Yu, SZ | 1 |
| Ueno, Y | 1 |
| Brown-Peterson, NJ | 1 |
| Krol, RM | 1 |
| Zhu, Y | 1 |
| Hawkins, WE | 1 |
| Murasaki, G | 1 |
| Nakanishi, K | 1 |
| Miyata, Y | 1 |
| Shinohara, Y | 1 |
| Ito, N | 2 |
| Schumacher, J | 1 |
| Osswald, H | 1 |
| Wayss, K | 1 |
| Maier-borst, W | 1 |
| Ogawa, K | 1 |
| Hasegawa, R | 1 |
| Wada, S | 1 |
| Yamaguchi, S | 1 |
| Couch, JA | 1 |
| Hwang, DL | 1 |
| Lev-Ran, A | 1 |
| Tay, YC | 1 |
| De Meyts, P | 1 |
| Bunton, TE | 1 |
| Althoff, J | 1 |
| Fehst, HJ | 1 |
| Mohr, U | 1 |
| Nii, A | 1 |
| Nakayama, H | 1 |
| Inoue, S | 1 |
| Fujiwara, K | 1 |
| Stout, DL | 1 |
| Becker, FF | 1 |
27 other studies available for diethylnitrosamine and Liver Dysfunction
| Article | Year |
|---|---|
Adipose stem cells preincubated with theanine exert liver regeneration through increase of stem cell paracrine VEGF and suppression of ROS, pyroptosis as well as autophagy markers in liver damage induced by N-nitrosodiethylamine.
Topics: Adipose Tissue; Animals; Antioxidants; Autophagy; Biomarkers; Caspases; Diethylnitrosamine; Glutamat | 2022 |
Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin.
Topics: Aging; Animals; Dasatinib; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Disease Progr | 2021 |
NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Calgranulin A; Calgranulin B; Carcinoma, Hepatocellular; Chemokine CXCL1 | 2015 |
In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury, Chronic; Concanavalin A; Diethylnitr | 2011 |
Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Apoptosis; bcl-Associated Death Protein; Cocarc | 2011 |
Lack of modification of rat hepatocarcinogenesis by fernane-type triterpenoids, isolated from a Euphorbia genus.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Diethylnitrosa | 2002 |
Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci.
Topics: Agaricus; Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers, Tumor; Brazil; Bromodeoxyuridine; | 2003 |
[Evaluation of early stage diffused liver lesions with MR functional diffusion-weighted imaging--an experimental study].
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Diffusion Magnetic Resonance Im | 2005 |
Bone disorders in experimentally induced liver disease in growing rats.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tet | 2005 |
Effect of Cassia fistula Linn. leaf extract on diethylnitrosamine induced hepatic injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Alkylating Agents; Animals; Antioxidants; Aspartate Amin | 2007 |
Impediment of diethylnitrosamine induced hepatotoxicity in male Balb/c mice by pretreatment with aqueous Azadirachta indica leaf extract.
Topics: Alkylating Agents; Animals; Azadirachta; Chemical and Drug Induced Liver Injury; Cytochrome P-450 En | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
[DNase II activation in rat liver in the course of acute diethylnitrosamine-induced damage (author's transl)].
Topics: Animals; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cycloheximide; Cytosol; Deoxyribonucl | 1981 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Iron promotes DEN initiated GST-P foci in rat liver.
Topics: Animals; Biomarkers; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitros | 1997 |
Chronic liver injury promotes hepatocarcinogenesis of the LEC rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Copper; Dieth | 1998 |
Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats.
Topics: Aflatoxin B1; Animals; Bacterial Toxins; Biomarkers; Chemical and Drug Induced Liver Injury; Diethyl | 1999 |
N-nitrosodiethylamine initiation of carcinogenesis in Japanese medaka (Oryzias latipes): hepatocellular proliferation, toxicity, and neoplastic lesions resulting from short term, low level exposure.
Topics: Age Factors; Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Chemical and Drug Induced L | 1999 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo | 1979 |
Uptake and excretion of 61Cu and 64Cu-myambutol by the liver. Experimental studies in rats and possibilities of a functional liver test in humans.
Topics: Animals; Ceruloplasmin; Copper; Diethylnitrosamine; Ethambutol; Humans; Liver; Liver Diseases; Liver | 1976 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Spongiosis hepatis: chemical induction, pathogenesis, and possible neoplastic fate in a teleost fish model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyprinidae; Diethylnitrosamine; Disease Models, Ani | 1991 |
Hepatotoxicity induced by diethylnitrosamine causes no significant disturbances of systemic glucose homeostasis in rats.
Topics: Animals; Aspartate Aminotransferases; Blood Glucose; Chemical and Drug Induced Liver Injury; Diethyl | 1990 |
Hepatopathology of diethylnitrosamine in the medaka (Oryzias latipes) following short-term exposure.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose-Response Relationship, Dru | 1990 |
The influence of metabolic liver defects on diethylnitrosamine (NDEA)-carcinogenesis in Gunn rats.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Hemangioendothelioma; Heman | 1985 |
Liver lesions in mice treated with diethylnitrosamine and inoculated with the Tyzzer's organism.
Topics: Animals; Bacillus; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Female; Liver Disease | 1987 |
Heme enzyme patterns in rat liver nodules and tumors.
Topics: 2-Acetylaminofluorene; 5-Aminolevulinate Synthetase; Animals; Catalase; Chemical and Drug Induced Li | 1987 |