diethylnitrosamine has been researched along with Liver Cirrhosis in 84 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 8.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| "To investigate whether hepatic oval cells are activated in diethylnitrosamine (DEN)-induced rat liver cirrhosis, and to explore its mechanism." | 7.76 | Hepatic oval cells activated by hepatocyte apoptosis in diethylnitrosamine-induced rat liver cirrhosis. ( Deng, JJ; Ge, W; Song, QB; Wu, YG; Xu, XM; Yuan, GJ, 2010) |
| " To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma." | 7.75 | Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009) |
| " Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation." | 5.56 | Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 5.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 4.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| " We observed that FUN14 domain-containing 1 (FUNDC1), a previously characterized mitophagy receptor, accumulates in most human hepatocellular carcinomas (HCCs), and we thus explored the role of FUNDC1-mediated mitophagy in HCC initiation and progression in a mouse model in which HCC is induced by the chemical carcinogen, diethylnitrosamine (DEN)." | 3.91 | FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice. ( Chen, Q; Du, L; Fan, Y; Huang, X; Jin, H; Li, W; Li, Y; Liu, L; Siraj, S; Wang, J; Wang, X; Yang, X, 2019) |
| "To investigate whether hepatic oval cells are activated in diethylnitrosamine (DEN)-induced rat liver cirrhosis, and to explore its mechanism." | 3.76 | Hepatic oval cells activated by hepatocyte apoptosis in diethylnitrosamine-induced rat liver cirrhosis. ( Deng, JJ; Ge, W; Song, QB; Wu, YG; Xu, XM; Yuan, GJ, 2010) |
| " To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma." | 3.75 | Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009) |
| "Gadolinium-enhanced multi-phase dynamic imaging has improved the accuracy of the diagnosis of hypervascular hepatocellular carcinoma (HCC), but using gadolinium-enhanced dynamic imaging alone is problematic in evaluating hypovascular HCC." | 3.75 | Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents. ( Bian, J; Guo, DM; Liu, SF; Qiu, TS; Wang, CZ, 2009) |
| "Hepatocellular carcinoma (HCC) was induced by diethylnitrosamine in 70 treated rats with 20 normal rats used as controls." | 3.73 | In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model. ( Li, X; Xie, JX; Xu, H; Yang, ZH, 2006) |
| "Autophagy plays a dual role in liver cancer, as it suppresses tumor initiation and promotes tumor progression." | 1.72 | Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis. ( Ballabio, A; Chao, X; Ding, WX; Hlobik, M; Ni, HM; Wang, S, 2022) |
| "Liver fibrosis is a complex process characterized by the excessive accumulation of extracellular matrix (ECM) and an alteration in liver architecture, as a result of most types of chronic liver diseases such as cirrhosis, hepatocellular carcinoma (HCC) and liver failure." | 1.62 | Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation. ( González, DR; Herrera Vielma, F; Rodríguez, MJ; Sabaj, M; Tolosa, G; Zúñiga, MJ; Zúñiga-Hernández, J, 2021) |
| "TREM-2 plays a protective role in hepatocarcinogenesis via different pleiotropic effects, suggesting that TREM-2 agonism should be investigated as it might beneficially impact HCC pathogenesis in a multifactorial manner." | 1.62 | TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. ( Agirre-Lizaso, A; Andersen, JB; Aspichueta, P; Azkargorta, M; Banales, JM; Bujanda, L; Elortza, F; Esparza-Baquer, A; Hijona, E; Jimenez-Agüero, R; Knapp, S; La Casta, A; Labiano, I; Landa, A; Mann, DA; Munoz-Garrido, P; O'Rourke, CJ; Oakley, F; Perugorria, MJ; Riaño, I; Rodrigues, PM; Schabbauer, G; Sharif, O; Vogel, A; Zaki, MYW; Zhuravleva, E, 2021) |
| "The role of TTP in nonalcoholic steatohepatitis and HCC development was further examined through in vivo/vitro approaches using liver-specific TTP knockout mice and a panel of hepatic cancer cells." | 1.62 | Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. ( Bejuy, O; Berthou, F; Blackshear, PJ; Colin, DJ; Correia de Sousa, M; De Vito, C; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Rubbia-Brandt, L; Sobolewski, C, 2021) |
| "The DEN-induced liver cirrhosis could develop into three time zone of fibrosis, cirrhosis and cancer, and the histological patterns in the model are similar to those described in humans." | 1.56 | Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis. ( Bai, L; Chen, Q; Jiang, S; Lai, J; Yang, W; You, X; Zhang, H, 2020) |
| " Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation." | 1.56 | Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020) |
| "Liver fibrosis is a complex process associated to most types of chronic liver disease, which is characterized by a disturbance of hepatic tissue architecture and the excessive accumulation of extracellular matrix." | 1.56 | Pro-Resolving Lipid Mediator Resolvin E1 Mitigates the Progress of Diethylnitrosamine-Induced Liver Fibrosis in Sprague-Dawley Rats by Attenuating Fibrogenesis and Restricting Proliferation. ( Castillo, I; Donoso, W; González, DR; Herrera, F; Orrego, R; Rodríguez, MJ; Zúñiga-Hernández, J, 2020) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 1.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "In the rat hepatocarcinogenesis model, unexpectedly, CYP2E1 activity was found to decrease from hepatofibrosis to hepatocarcinogenesis." | 1.48 | From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor. ( Gao, J; Gao, N; Jin, H; Li, J; Qiao, HL; Wang, GJ; Wang, Z; Wen, Q; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| "Examination of liver cancer in diethylnitrosamine (DEN)-treated CUGBP1-S302A mice showed these mice develop much more severe liver cancer that is associated with elimination of the mutant CUGBP1." | 1.46 | RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner. ( Cast, A; Iakova, P; Karns, R; Lewis, K; Stock, L; Timchenko, L; Timchenko, N; Valanejad, L; Wei, C; Wright, M, 2017) |
| "The adenosine derivative treatment reduced diethylnitrosamine-induced collagen expression and decreased the proportion of nodules positive for the tumor marker γ-glutamyl transferase." | 1.46 | Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats. ( Chagoya de Sánchez, V; Pérez-Carreón, JI; Pérez-Martínez, L; Velasco-Loyden, G; Vidrio-Gómez, S, 2017) |
| "The development of hepatocellular carcinoma (HCC) is a common consequence of advanced liver fibrosis but the interactions between fibrogenesis and carcinogenesis are still poorly understood." | 1.43 | TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver. ( Bohner, A; Dapito, DH; Lammert, F; Schwabe, RF; Weber, SN, 2016) |
| "Diethylnitrosamine (DEN) is a potent toxic material that can cause necrosis and subsequent fibrosis in the liver." | 1.43 | Protective Effects of Ethyl Acetate Soluble Fraction of Limonium tetragonum on Diethylnitrosamine-Induced Liver Fibrosis in Rats. ( Heo, JD; Jeong, EJ; Kim, NH; Kim, TB; Rho, JR; Yang, MH, 2016) |
| "Experimentally induced hepatocellular carcinoma is considered one of the representative laboratory models for studying this process." | 1.42 | Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells. ( Cai, JC; Cathopoulis, T; Han, R; Li, X; Liu, F; Liu, GY; Lu, K; Luo, G; Peng, B; Shi, SL; Yang, L, 2015) |
| "Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC)." | 1.42 | Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis. ( Chung, YA; Ham, HJ; Jang, KS; Jung, YJ; Lee, J; Lee, JH; Maeng, LS; Park, MS; Park, SI, 2015) |
| "Sorafenib treatment restored mitochondrial function and reduced collagen deposition by nearly 63% compared to the NASH group." | 1.42 | Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model. ( Barbeiro, DF; Bida, PM; Carrilho, FJ; Coelho, AM; Cogliati, B; D'Albuquerque, LA; Kubrusly, MS; Mazo, DF; Oliveira, CP; Pereira, IV; Souza, HP; Stefano, JT; Torres, MM; Xerfan, MP, 2015) |
| "Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis." | 1.40 | The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014) |
| "A stable zebrafish liver fibrosis model was successfully established by inducing liver damage to facilitate studies of the pathogenesis of liver fibrosis and screening therapeutic drugs." | 1.40 | [Establishment of a hepatic fibrosis model induced by diethylnitrosamine in zebrafish]. ( Chen, X; Dai, W; Hou, J; Liu, L; Wang, K; Zheng, X, 2014) |
| "The model of liver cirrhosis was established by induction of diethylnitrosamine (DEN) in rats." | 1.40 | Infusion of human umbilical cord‑derived mesenchymal stem cells effectively relieves liver cirrhosis in DEN‑induced rats. ( Han, J; Hong, J; Hu, H; Huang, Y; Jin, H; Li, L; Liu, J; Qian, Q; Qiu, L; Wang, D; Wu, M, 2014) |
| "A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used." | 1.40 | Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014) |
| "The percentage of liver fibrosis was assessed via quantitative analysis of Masson trichrome staining using an average of 30 fields per section." | 1.39 | Intra-voxel incoherent motion MRI in rodent model of diethylnitrosamine-induced liver fibrosis. ( Deng, J; Guo, Y; Jin, N; Larson, AC; Omary, RA; White, SB; Yang, GY; Zhang, Y, 2013) |
| "Liver fibrosis was induced in rats with diethylnitrosamine and in mice with carbon tetrachloride." | 1.38 | Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models. ( Alford, JK; Caravan, P; Fuchs, BC; Guimaraes, AR; Lauwers, GY; Loving, GS; Polasek, M; Schühle, DT; Tanabe, KK; Uppal, R; Wei, L; Yamada, S, 2012) |
| "Patients with liver cirrhosis and HCC had significantly increased serum endotoxin levels." | 1.38 | Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. ( Chen, HY; Dai, RY; He, YQ; Li, YQ; Li, Z; Lin, Y; Liu, Q; Qiu, BJ; Shan, L; Tan, YX; Tang, L; Wang, C; Wang, HY; Wu, FQ; Wu, H; Yan, HX; Yang, W; Yu, LX; Zhai, B; Zhang, HL; Zheng, LY, 2012) |
| "Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC)." | 1.38 | Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. ( Chen, C; Ding, J; Feng, GS; Han, T; Huang, L; Li, Z; Ning, BF; Sun, W; Wang, C; Wang, HY; Wen, W; Wu, K; Wu, MC; Xie, WF; Yang, W, 2012) |
| " These results provide a rationale for long-term MET dosing in future clinical trials of HCC treatment." | 1.37 | Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma. ( Bae, SH; Choi, JY; Jang, JW; Jung, CK; Kwon, JH; Park, ST; Yoon, SK; You, CR, 2011) |
| "Recent studies have demonstrated that frequent, low-dose metronomic (MET) dosing of cytotoxic agents may not only be as efficient as conventional maximum tolerated dose (MTD) chemotherapy but also less toxic." | 1.36 | Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis. ( Bae, SH; Choi, JY; Hur, W; Jang, JW; Kim, GD; Kim, JD; Kwon, JH; Park, JA; Park, ST; Woo, HY; Yoo, CR; Yoon, SK, 2010) |
| "Liver fibrosis was induced in 27 male Wistar rats by means of weekly oral gavage with 5 mL of 1." | 1.36 | Carbogen gas-challenge BOLD MR imaging in a rat model of diethylnitrosamine-induced liver fibrosis. ( Chadashvili, T; Deng, J; Guo, Y; Jin, N; Larson, AC; Omary, RA; Yang, GY; Zhang, Y; Zhang, Z, 2010) |
| "In the liver cirrhosis and liver cancer group, Mphi had more prominences, meanwhile much more mitochondria, ribosome, rough endoplasmic reticulum, lysosome can be found in the cytoplasm, especially in the liver cancer group." | 1.35 | Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats. ( Huang, C; Li, ZF; Liu, ZW; Pan, D; Zhang, S; Zhou, R, 2009) |
| "In CDAA-induced liver fibrosis model, PE revealed a marked inhibitory effect of liver fibrosis development." | 1.31 | Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. ( Fukui, H; Ikenaka, Y; Imazu, H; Kuriyama, S; Nakatani, T; Noguchi, R; Tsujinoue, H; Yanase, K; Yoshii, J; Yoshiji, H, 2002) |
| "The average score of liver cirrhosis associated with HCV was 1." | 1.30 | Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. ( Hino, S; Kamahora, T; Kawasaki, H; Miyata, H; Shimada, A; Shiota, G; Shiraki, K; Terada, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.57) | 18.7374 |
| 1990's | 1 (1.19) | 18.2507 |
| 2000's | 11 (13.10) | 29.6817 |
| 2010's | 54 (64.29) | 24.3611 |
| 2020's | 15 (17.86) | 2.80 |
| Authors | Studies |
|---|---|
| Ghufran, H | 1 |
| Azam, M | 1 |
| Mehmood, A | 1 |
| Butt, H | 1 |
| Riazuddin, S | 1 |
| Chao, X | 1 |
| Wang, S | 3 |
| Hlobik, M | 1 |
| Ballabio, A | 1 |
| Ni, HM | 1 |
| Ding, WX | 1 |
| Mohamad, MI | 1 |
| Desoky, IA | 1 |
| Ahmed Zaki, K | 1 |
| Sadek, DR | 1 |
| Kamal Kassim, S | 1 |
| Abdel-Wahab Mohamed, D | 1 |
| Rodríguez, MJ | 2 |
| Sabaj, M | 1 |
| Tolosa, G | 1 |
| Herrera Vielma, F | 1 |
| Zúñiga, MJ | 1 |
| González, DR | 2 |
| Zúñiga-Hernández, J | 2 |
| Wu, B | 1 |
| Feng, J | 1 |
| Guo, J | 1 |
| Wang, J | 4 |
| Xiu, G | 1 |
| Xu, J | 3 |
| Ning, K | 1 |
| Ling, B | 1 |
| Fu, Q | 1 |
| Chen, Q | 2 |
| You, X | 1 |
| Yang, W | 4 |
| Jiang, S | 2 |
| Lai, J | 2 |
| Zhang, H | 3 |
| Bai, L | 2 |
| Lin, YH | 1 |
| Zhang, S | 4 |
| Zhu, M | 1 |
| Lu, T | 1 |
| Chen, K | 1 |
| Wen, Z | 1 |
| Xiao, G | 1 |
| Luo, D | 1 |
| Jia, Y | 1 |
| Li, L | 2 |
| MacConmara, M | 1 |
| Hoshida, Y | 4 |
| Singal, AG | 1 |
| Yopp, A | 1 |
| Wang, T | 2 |
| Zhu, H | 1 |
| Lee, DY | 1 |
| Yun, SM | 1 |
| Song, MY | 1 |
| Ji, SD | 1 |
| Son, JG | 1 |
| Kim, EH | 1 |
| Sojoodi, M | 2 |
| Wei, L | 4 |
| Erstad, DJ | 2 |
| Yamada, S | 3 |
| Fujii, T | 2 |
| Hirschfield, H | 1 |
| Kim, RS | 1 |
| Lauwers, GY | 4 |
| Lanuti, M | 3 |
| Tanabe, KK | 5 |
| Fuchs, BC | 5 |
| Esparza-Baquer, A | 1 |
| Labiano, I | 1 |
| Sharif, O | 1 |
| Agirre-Lizaso, A | 1 |
| Oakley, F | 1 |
| Rodrigues, PM | 1 |
| Zhuravleva, E | 1 |
| O'Rourke, CJ | 1 |
| Hijona, E | 1 |
| Jimenez-Agüero, R | 1 |
| Riaño, I | 1 |
| Landa, A | 1 |
| La Casta, A | 1 |
| Zaki, MYW | 1 |
| Munoz-Garrido, P | 1 |
| Azkargorta, M | 1 |
| Elortza, F | 1 |
| Vogel, A | 1 |
| Schabbauer, G | 1 |
| Aspichueta, P | 1 |
| Andersen, JB | 1 |
| Knapp, S | 1 |
| Mann, DA | 1 |
| Bujanda, L | 1 |
| Banales, JM | 1 |
| Perugorria, MJ | 1 |
| Dolicka, D | 1 |
| Sobolewski, C | 1 |
| Gjorgjieva, M | 1 |
| Correia de Sousa, M | 1 |
| Berthou, F | 1 |
| De Vito, C | 1 |
| Colin, DJ | 1 |
| Bejuy, O | 1 |
| Fournier, M | 1 |
| Maeder, C | 1 |
| Blackshear, PJ | 1 |
| Rubbia-Brandt, L | 1 |
| Foti, M | 1 |
| Herrera, F | 1 |
| Donoso, W | 1 |
| Castillo, I | 1 |
| Orrego, R | 1 |
| Haberl, EM | 1 |
| Pohl, R | 1 |
| Rein-Fischboeck, L | 1 |
| Höring, M | 1 |
| Krautbauer, S | 1 |
| Liebisch, G | 1 |
| Buechler, C | 1 |
| Sharma, R | 1 |
| Ali, T | 1 |
| Negi, I | 1 |
| Das, A | 1 |
| Duseja, A | 1 |
| Kaur, J | 1 |
| Zhang, B | 1 |
| Meng, F | 1 |
| Liu, Y | 2 |
| Yuan, Y | 1 |
| Wu, D | 2 |
| Cui, Y | 1 |
| Guo, H | 1 |
| Liang, S | 1 |
| Wang, W | 1 |
| Klos, M | 1 |
| Morgenstern, S | 1 |
| Sun, L | 1 |
| Ma, K | 1 |
| Liu, X | 2 |
| Wang, Y | 2 |
| Han, J | 2 |
| Yang, G | 1 |
| Zheng, C | 1 |
| Li, X | 3 |
| Zhou, S | 1 |
| Ji, C | 1 |
| Bai, Q | 1 |
| Liu, L | 4 |
| Molina-Aguilar, C | 1 |
| Guerrero-Carrillo, MJ | 1 |
| Espinosa-Aguirre, JJ | 1 |
| Olguin-Reyes, S | 1 |
| Castro-Belio, T | 1 |
| Vázquez-Martínez, O | 1 |
| Rivera-Zavala, JB | 1 |
| Díaz-Muñoz, M | 1 |
| Perumal, N | 1 |
| Perumal, M | 1 |
| Halagowder, D | 1 |
| Sivasithamparam, N | 1 |
| Lewis, K | 1 |
| Valanejad, L | 1 |
| Cast, A | 1 |
| Wright, M | 1 |
| Wei, C | 2 |
| Iakova, P | 1 |
| Stock, L | 1 |
| Karns, R | 1 |
| Timchenko, L | 1 |
| Timchenko, N | 1 |
| Song, LY | 1 |
| Ma, YT | 1 |
| Wu, CF | 1 |
| Wang, CJ | 1 |
| Fang, WJ | 1 |
| Liu, SK | 1 |
| Romualdo, GR | 2 |
| Grassi, TF | 1 |
| Goto, RL | 1 |
| Tablas, MB | 1 |
| Bidinotto, LT | 1 |
| Fernandes, AAH | 2 |
| Cogliati, B | 3 |
| Barbisan, LF | 2 |
| Funaki, M | 1 |
| Kitabayashi, J | 1 |
| Shimakami, T | 1 |
| Nagata, N | 1 |
| Sakai, Y | 1 |
| Takegoshi, K | 1 |
| Okada, H | 1 |
| Murai, K | 1 |
| Shirasaki, T | 1 |
| Oyama, T | 1 |
| Yamashita, T | 1 |
| Ota, T | 1 |
| Takuwa, Y | 1 |
| Honda, M | 1 |
| Kaneko, S | 1 |
| Chen, Y | 2 |
| Meng, L | 1 |
| Shang, H | 1 |
| Dou, Q | 1 |
| Lu, Z | 1 |
| Wang, Z | 2 |
| He, X | 1 |
| Song, Y | 1 |
| Wang, G | 1 |
| Xiao, K | 1 |
| Gao, J | 2 |
| Weng, S | 1 |
| Xu, C | 2 |
| Qiao, HL | 3 |
| Husain, H | 1 |
| Latief, U | 1 |
| Ahmad, R | 1 |
| Wang, GJ | 1 |
| Gao, N | 2 |
| Li, J | 2 |
| Zhang, YF | 1 |
| Zhou, J | 1 |
| Zhang, HX | 1 |
| Wen, Q | 2 |
| Jin, H | 3 |
| Li, W | 1 |
| Li, Y | 2 |
| Siraj, S | 1 |
| Fan, Y | 1 |
| Yang, X | 2 |
| Huang, X | 1 |
| Wang, X | 1 |
| Du, L | 1 |
| Prata, GB | 1 |
| da Silva, TC | 1 |
| Moreno, FS | 1 |
| Li, S | 2 |
| Ghoshal, S | 1 |
| Arora, G | 1 |
| Masia, R | 1 |
| Baumert, TF | 1 |
| Guo, YY | 1 |
| Fang, Y | 1 |
| Wang, CE | 1 |
| Das, BK | 1 |
| Choukimath, SM | 1 |
| Gadad, PC | 1 |
| D'Souza, JC | 1 |
| Sultan, LR | 1 |
| Hunt, SJ | 1 |
| Schultz, SM | 1 |
| Brice, AK | 1 |
| Wood, AKW | 1 |
| Sehgal, CM | 1 |
| Yang, C | 1 |
| Lu, W | 1 |
| Lin, T | 1 |
| You, P | 1 |
| Ye, M | 1 |
| Huang, Y | 2 |
| Jiang, X | 1 |
| Wang, C | 4 |
| Wang, F | 1 |
| Lee, MH | 1 |
| Yeung, SC | 1 |
| Johnson, RL | 1 |
| Tsai, RY | 1 |
| Frazier, ML | 1 |
| McKeehan, WL | 1 |
| Luo, Y | 1 |
| Zhang, Y | 3 |
| Jin, N | 2 |
| Deng, J | 2 |
| Guo, Y | 2 |
| White, SB | 1 |
| Yang, GY | 2 |
| Omary, RA | 2 |
| Larson, AC | 2 |
| Man, S | 1 |
| Fan, W | 1 |
| Gao, W | 1 |
| Liu, Z | 1 |
| Li, H | 1 |
| Chappell, G | 1 |
| Kutanzi, K | 2 |
| Uehara, T | 3 |
| Tryndyak, V | 1 |
| Hong, HH | 1 |
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84 other studies available for diethylnitrosamine and Liver Cirrhosis
| Article | Year |
|---|---|
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamin | 2021 |
Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Topics: Alcohol Drinking; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinogenes | 2022 |
Pterostilbene ameliorates the disrupted Adars expression and improves liver fibrosis in DEN-induced liver injury in Wistar rats: A novel potential effect.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Diethylnitrosamine; Gene Expression; L | 2022 |
Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation.
Topics: Animals; Apoptosis; Body Weight; Cell Cycle; Cell Proliferation; Cytokines; Diethylnitrosamine; Doco | 2021 |
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib | 2022 |
Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Inflammation; Liver; | 2020 |
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced | 2020 |
Administration of Steamed and Freeze-Dried Mature Silkworm Larval Powder Prevents Hepatic Fibrosis and Hepatocellular Carcinogenesis by Blocking TGF-β/STAT3 Signaling Cascades in Rats.
Topics: Animals; Bombyx; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; | 2020 |
Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; Catechin; Cellular Senescen | 2020 |
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.
Topics: Adult; Aged; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferatio | 2021 |
Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Diethylnitr | 2021 |
Pro-Resolving Lipid Mediator Resolvin E1 Mitigates the Progress of Diethylnitrosamine-Induced Liver Fibrosis in Sprague-Dawley Rats by Attenuating Fibrogenesis and Restricting Proliferation.
Topics: Alanine Transaminase; Animals; Apoptosis; Cell Proliferation; Diethylnitrosamine; Eicosapentaenoic A | 2020 |
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Def | 2020 |
Dietary modulations of folic acid affect the development of diethylnitrosamine induced hepatocellular carcinoma in a rat model.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Folic Acid; Liver; Liver Cirrhosis; Liver Ne | 2021 |
Inhibition of TGFβ1 accelerates regeneration of fibrotic rat liver elicited by a novel two-staged hepatectomy.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Hepatectomy; Hepatic Stellate Cells; Hepatocytes; | 2021 |
Time-caloric restriction inhibits the neoplastic transformation of cirrhotic liver in rats treated with diethylnitrosamine.
Topics: Animals; Caloric Restriction; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, Neopla | 2017 |
Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling.
Topics: Animals; Apoptosis Regulatory Proteins; Diethylnitrosamine; Flavonoids; Hepatic Stellate Cells; Huma | 2017 |
RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.
Topics: Aging; Animals; Carcinogenesis; CELF1 Protein; Child; Diethylnitrosamine; Disease Models, Animal; E2 | 2017 |
MicroRNA-195 Activates Hepatic Stellate Cells In Vitro by Targeting Smad7.
Topics: 3' Untranslated Regions; Animals; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regula | 2017 |
An integrative analysis of chemically-induced cirrhosis-associated hepatocarcinogenesis: Histological, biochemical and molecular features.
Topics: Alanine Transaminase; Animals; Annexin A2; Aspartate Aminotransferases; Carcinogenesis; Collagen; Co | 2017 |
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Gen | 2017 |
β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin.
Topics: AC133 Antigen; Animals; beta Catenin; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tu | 2018 |
Inhibitory effect of chlormethiazole on the toxicokinetics of diethylnitrosamine in normal and hepatofibrotic rats.
Topics: Animals; Area Under Curve; Chlormethiazole; Chromatography, High Pressure Liquid; Diethylnitrosamine | 2019 |
Pomegranate action in curbing the incidence of liver injury triggered by Diethylnitrosamine by declining oxidative stress via Nrf2 and NFκB regulation.
Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver | 2018 |
From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor.
Topics: Adult; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Diethylnitrosami | 2018 |
FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice.
Topics: Animals; Carcinoma, Hepatocellular; Caspase 1; Diethylnitrosamine; Hepatocytes; Humans; Inflammasome | 2019 |
Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Susceptibility | 2018 |
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High- | 2019 |
High CYP2E1 activity aggravates hepatofibrosis by limiting macrophage polarization towards the M2 phenotype.
Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cytochrome P-450 CYP2E1; D | 2019 |
Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Carcinoma, Hepatocellular; Diabetes Mellitus, Experimen | 2019 |
B-mode ultrasound for the assessment of hepatic fibrosis: a quantitative multiparametric analysis for a radiomics approach.
Topics: Animals; Biopsy; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatic Veins; Humans; | 2019 |
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.
Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; | 2013 |
Intra-voxel incoherent motion MRI in rodent model of diethylnitrosamine-induced liver fibrosis.
Topics: Animals; Artifacts; Diethylnitrosamine; Disease Models, Animal; Humans; Image Enhancement; Image Int | 2013 |
Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats.
Topics: Animals; Diethylnitrosamine; DNA Fragmentation; Gene Expression Regulation; Liver Cirrhosis; Liver C | 2014 |
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas | 2014 |
Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription.
Topics: Animals; Astragalus Plant; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation | 2014 |
Infusion of human umbilical cord‑derived mesenchymal stem cells effectively relieves liver cirrhosis in DEN‑induced rats.
Topics: Animals; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Separation; Diethylnitrosamine | 2014 |
Chemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions.
Topics: Animals; Cell Growth Processes; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Lipids; Liver; | 2014 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul | 2014 |
[Establishment of a hepatic fibrosis model induced by diethylnitrosamine in zebrafish].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Zebrafish | 2014 |
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv | 2014 |
Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis.
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Cattle; CCAAT-Binding Factor; | 2015 |
Diethylnitrosamine-induced cirrhosis in Wistar rats: an experimental feasibility study.
Topics: Animals; Blotting, Western; Body Weight; Diethylnitrosamine; Feasibility Studies; Lipid Peroxidation | 2015 |
Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model.
Topics: Animals; Chaperonin 60; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Fibrillar Collag | 2015 |
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chemical and | 2015 |
Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Feasibility Studies; Fluorodeoxyglucose F18; | 2015 |
Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chemokine CCL2; Cytokines; Diethylnitrosa | 2015 |
Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats.
Topics: Animals; Antioxidants; Blueberry Plants; Catalase; Diethylnitrosamine; Glutathione; Lipid Peroxidati | 2016 |
Protective Effects of Ethyl Acetate Soluble Fraction of Limonium tetragonum on Diethylnitrosamine-Induced Liver Fibrosis in Rats.
Topics: Acetates; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Diethyln | 2016 |
TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2016 |
Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model.
Topics: Angiography; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease Models, | 2017 |
Functional liver tissue engineering by an adult mouse liver-derived neuro-glia antigen 2-expressing stem/progenitor population.
Topics: Aging; Animals; Antigens; Cell Differentiation; Cell Lineage; Cell Proliferation; Diethylnitrosamine | 2018 |
Combined magnetic resonance elastography and collagen molecular magnetic resonance imaging accurately stage liver fibrosis in a rat model.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Diethylnitrosamine; Disease Models, Animal; Elasticit | 2017 |
Fruiting Bodies of Antrodia cinnamomea and Its Active Triterpenoid, Antcin K, Ameliorates N-Nitrosodiethylamine-Induced Hepatic Inflammation, Fibrosis and Carcinogenesis in Rats.
Topics: Alkylating Agents; Animals; Antrodia; Apoptosis; Autophagy; Carcinogenesis; Carcinoma, Hepatocellula | 2017 |
Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.
Topics: Animals; beta Catenin; beta Karyopherins; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line | 2017 |
Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats.
Topics: Adenosine; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Disease Models, Animal; Liver Cirrh | 2017 |
Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Progression; Hepatitis; | 2017 |
Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis.
Topics: Animals; Apoptosis; Carcinogens; Cell Proliferation; Diethylnitrosamine; Genetic Therapy; Interferon | 2008 |
Impact of insulin resistance on the progression of chronic liver diseases.
Topics: Animals; Cell Proliferation; Chronic Disease; Collagen; Diethylnitrosamine; Disease Progression; Glu | 2008 |
Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease M | 2009 |
Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model.
Topics: Alkylating Agents; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Disease Progression; Gene Ex | 2009 |
Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Body Weight; Cell Proliferation; Cyclophospha | 2010 |
Carbogen gas-challenge BOLD MR imaging in a rat model of diethylnitrosamine-induced liver fibrosis.
Topics: Analysis of Variance; Animals; Carbon Dioxide; Diethylnitrosamine; Disease Progression; Image Proces | 2010 |
Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats.
Topics: Animals; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Liver Neoplas | 2009 |
Hepatic oval cells activated by hepatocyte apoptosis in diethylnitrosamine-induced rat liver cirrhosis.
Topics: Animals; Apoptosis; Cell Proliferation; Diethylnitrosamine; Hepatocytes; Immunohistochemistry; In Si | 2010 |
Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; | 2010 |
Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis.
Topics: Acyltransferases; Animals; Carbon Tetrachloride; Cell Transformation, Neoplastic; Cells, Cultured; D | 2011 |
Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis.
Topics: Aging; Animals; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin E; Cyclooxy | 2011 |
Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Cyclophosphamide; Die | 2011 |
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Contrast Media; Diethylnitrosamine; Disease Models, | 2012 |
Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Anti-Bacterial Agents; Bifidobacterium; Carcinoma, Hepatocellular; Cytok | 2012 |
Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development.
Topics: AC133 Antigen; Animals; Antigens, CD; Antigens, Differentiation; Antigens, Neoplasm; Biomarkers, Tum | 2012 |
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
Topics: Animals; Animals, Newborn; Carbon Tetrachloride; Cell Transformation, Neoplastic; Diethylnitrosamine | 2013 |
[Influence of bear bile on rat hepatocarcinoma induced by diethylnitrosamine].
Topics: Actins; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Bile; Bil | 2012 |
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].
Topics: Aging; Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Cyclin-Dependent Kinase In | 2003 |
[HEPATOTOXIC AND CIRRHOGENIC EFFECT OF DIETHYLNITROSAMINE IN DOGS].
Topics: Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dogs; Gastrointestinal Diseases; Hepatit | 1964 |
Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Er | 2005 |
In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, | 2006 |
Transplantation of fetal liver epithelial progenitor cells ameliorates experimental liver fibrosis in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Diethylnitrosamine; Epithelial Cells; Fe | 2006 |
Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Biopsy, Needle; Carcinoma, Hepatocellular; Diethylnitros | 1998 |
Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carci
Topics: Animals; Base Sequence; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Ki | 2001 |
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.
Topics: Alkylating Agents; Angiotensin-Converting Enzyme Inhibitors; Animals; Choline; Diethylnitrosamine; D | 2002 |
Comparability of histological alterations during carcinogenesis in animals and man, with special reference to hepatocarcinogenesis in fish.
Topics: Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fish Diseases; Humans; H | 1977 |
Effects of diethylnitrosamine and cigarette smoke on hamsters.
Topics: Animals; Body Weight; Cricetinae; Diethylnitrosamine; Humans; Laryngeal Diseases; Liver Cirrhosis; L | 1976 |