diethylnitrosamine has been researched along with Innate Inflammatory Response in 63 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nimbolide is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties; however, its anticancer effects and molecular mechanism in hepatocellular carcinoma (HCC) remains obscure." | 7.96 | Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis. ( Ram, AK; Srinivas, BH; Vairappan, B, 2020) |
| "Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality." | 5.62 | Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma. ( Balaraman, G; Krishnan, P; Mari, A; Salam, S; Sirajduddin, I; Subramaniam, N; Sundaram, J; Thiruvengadam, D, 2021) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 5.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| " Take advantage of the combinatory treatment with a single dose of diethylnitrosamine (DEN) and chronic feeding with high-fat diet (HFD), we demonstrated that hepatic depdc5 deletion did not aggravate DEN&HFD induced liver tumorigenesis, probably due to its protective effects on diet-induced liver steatosis." | 4.02 | Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice. ( Huang, R; Li, Z; Ma, H; Ma, J; Wang, J; Wang, Q; Xiong, X; Xu, L; Yang, C, 2021) |
| " In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis." | 4.02 | Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks. ( Campbell, MJ; Clinton, SK; Coss, CC; Getaneh, S; Helms, TH; Kulp, SK; LeMoine, DM; Lucas, F; Mullins, RD; Phelps, MA; Schmidt, N; Thomas-Ahner, JM; Xie, Z, 2021) |
| " Nimbolide is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties; however, its anticancer effects and molecular mechanism in hepatocellular carcinoma (HCC) remains obscure." | 3.96 | Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis. ( Ram, AK; Srinivas, BH; Vairappan, B, 2020) |
| " In the second set of experiments, hypertrophy of the adipocytes was suppressed, and the concentration of adiponectin and leptin in the adipose tissue decreased by MCT." | 3.91 | Effects of Medium-chain Triglycerides Administration in Chemically-induced Carcinogenesis in Mice. ( Akazawa, Y; Fujii, H; Fukushima, H; Hagio, K; Ichikawa, D; Kono, H; Maruyama, S; Nakata, Y; Wakana, H, 2019) |
| " To explore the role of CHOP in hepatocarcinogenesis, we induced hepatocellular carcinoma (HCC) in wild type (wt) and CHOP knockout (KO) mice using the carcinogen N-diethylnitrosamine (DEN)." | 3.79 | CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. ( Chung, RT; Mueller, T; Nahmias, A; Scaiewicz, V; Shibolet, O; Tirosh, B, 2013) |
| "Autophagy plays a dual role in liver cancer, as it suppresses tumor initiation and promotes tumor progression." | 1.72 | Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis. ( Ballabio, A; Chao, X; Ding, WX; Hlobik, M; Ni, HM; Wang, S, 2022) |
| "Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality." | 1.62 | Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma. ( Balaraman, G; Krishnan, P; Mari, A; Salam, S; Sirajduddin, I; Subramaniam, N; Sundaram, J; Thiruvengadam, D, 2021) |
| "Liver fibrosis is a complex process characterized by the excessive accumulation of extracellular matrix (ECM) and an alteration in liver architecture, as a result of most types of chronic liver diseases such as cirrhosis, hepatocellular carcinoma (HCC) and liver failure." | 1.62 | Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation. ( González, DR; Herrera Vielma, F; Rodríguez, MJ; Sabaj, M; Tolosa, G; Zúñiga, MJ; Zúñiga-Hernández, J, 2021) |
| "Diethylnitrosamine (DEN) is a well-known hepatocarcinogen, and its oral administration causes severe liver damage including cancer." | 1.62 | 6-Gingerol, a Major Ingredient of Ginger Attenuates ( Almatroodi, SA; Almatroudi, A; Almutary, AG; Alrumaihi, F; Alsahli, MA; Anwar, S; Khan, AA; Rahmani, AH, 2021) |
| " Here, we describe steps to establish liver cancer in a rat model, via chronic administration of diethylnitrosamine." | 1.62 | Optimized protocol for an inducible rat model of liver tumor with chronic hepatocellular injury, inflammation, fibrosis, and cirrhosis. ( Chen, Z; Han, L; He, X; Li, S, 2021) |
| "All mice administered oral DEN developed liver fibrosis, liver cirrhosis and hepatocellular carcinoma (HCC)." | 1.56 | Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis. ( Bai, L; Chen, Q; Jiang, S; Lai, J; Yang, W; You, X; Zhang, H, 2020) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 1.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "Diethylnitrosamine was used to induce liver cancer in a rat model." | 1.48 | Correlation between HSD17B4 expression in rat liver cancer tissues and inflammation or proliferation. ( Lin, Z; Pan, LC; Xiao, HY; Yin, WJ, 2018) |
| "Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC)." | 1.48 | Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis. ( Dozmorov, M; Fisher, PB; Ghosh, S; Jariwala, N; Lai, Z; Mendoza, RG; Mukhopadhyay, ND; Robertson, CL; Sarkar, D; Subler, MA; Windle, JJ, 2018) |
| "Hepatic cancer is well known, and leading cancer around the world and remain asymptomatic diseases." | 1.48 | Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles. ( Falls, N; Kumar, V; Ramteke, PW; Singh Dangi, D; Singh, D; Singh, M; Verma, A; Yadav, E, 2018) |
| " The experiment was terminated after the 24 h of last dosage of Fe-NTA, and all the animals were sacrificed." | 1.43 | Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats. ( Arockianathan, PM; Sharmila, R; Sindhu, G, 2016) |
| "Wister rat model of liver cancer was set up using diethylnitrosamine (DEN)." | 1.43 | Correlation between angiogenic/inflammatory mediators in Wister rat model of liver dysplasia. ( Adel, S; Nasr, MI; Salem, TA; Talaat, RM, 2016) |
| "Bid participates in hepatic carcinogenesis but the mechanism is not fully understood." | 1.43 | Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. ( Chen, X; Dong, Z; Khambu, B; Luo, J; Michalopoulos, GK; Wu, S; Yan, S; Yin, XM; Yu, C, 2016) |
| "The incidence of liver cancer is higher in men than in women." | 1.43 | Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse. ( Grant, DM; Hanna, D; Riedmaier, AE; Sugamori, KS, 2016) |
| "Chronic liver inflammation is a crucial event in the development and growth of hepatocellular carcinoma (HCC)." | 1.42 | Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model. ( Al Masaoudi, M; Cubero, FJ; Gassler, N; Hatting, M; Liedtke, C; Nevzorova, YA; Peng, J; Sellge, G; Spannbauer, M; Trautwein, C, 2015) |
| "Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear." | 1.42 | Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015) |
| "Experimentally induced hepatocellular carcinoma is considered one of the representative laboratory models for studying this process." | 1.42 | Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells. ( Cai, JC; Cathopoulis, T; Han, R; Li, X; Liu, F; Liu, GY; Lu, K; Luo, G; Peng, B; Shi, SL; Yang, L, 2015) |
| "Liver cancer, predominantly hepatocellular carcinoma (HCC), represents a complex and fatal malignancy driven primarily by oxidative stress and inflammation." | 1.39 | Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis. ( Bhatia, D; Bishayee, A; Darvesh, AS; Meszaros, JG; Ohanyan, V; Thoppil, RJ, 2013) |
| "Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN)." | 1.35 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis. ( Bozova, S; Elpek, GO; Gokhan, GA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.17) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (6.35) | 29.6817 |
| 2010's | 38 (60.32) | 24.3611 |
| 2020's | 19 (30.16) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Balaraman, G | 1 |
| Sundaram, J | 1 |
| Mari, A | 1 |
| Krishnan, P | 1 |
| Salam, S | 1 |
| Subramaniam, N | 1 |
| Sirajduddin, I | 1 |
| Thiruvengadam, D | 1 |
| Xu, L | 1 |
| Yang, C | 1 |
| Wang, J | 1 |
| Li, Z | 1 |
| Huang, R | 1 |
| Ma, H | 1 |
| Ma, J | 1 |
| Wang, Q | 1 |
| Xiong, X | 1 |
| Ghufran, H | 1 |
| Azam, M | 1 |
| Mehmood, A | 1 |
| Butt, H | 1 |
| Riazuddin, S | 1 |
| Chao, X | 1 |
| Wang, S | 1 |
| Hlobik, M | 1 |
| Ballabio, A | 1 |
| Ni, HM | 1 |
| Ding, WX | 1 |
| Li, S | 2 |
| Li, Y | 2 |
| Sun, H | 1 |
| Jiang, Y | 1 |
| Pan, K | 1 |
| Su, Y | 1 |
| Bu, N | 1 |
| Zhang, T | 1 |
| Gu, HW | 1 |
| Gao, JX | 1 |
| Li, YS | 1 |
| Tang, HB | 1 |
| Rodríguez, MJ | 1 |
| Sabaj, M | 1 |
| Tolosa, G | 1 |
| Herrera Vielma, F | 1 |
| Zúñiga, MJ | 1 |
| González, DR | 1 |
| Zúñiga-Hernández, J | 1 |
| Yang, F | 1 |
| Shi, X | 1 |
| Yang, W | 2 |
| Gao, C | 1 |
| Cui, Z | 1 |
| Wang, W | 2 |
| Wang, Y | 1 |
| Wang, M | 1 |
| Liu, C | 2 |
| Hao, M | 1 |
| Shi, J | 1 |
| Zhang, X | 1 |
| Dang, S | 1 |
| Mansour, DF | 1 |
| Abdallah, HMI | 1 |
| Ibrahim, BMM | 1 |
| Hegazy, RR | 1 |
| Esmail, RSE | 1 |
| Abdel-Salam, LO | 1 |
| Guedj, A | 1 |
| Volman, Y | 1 |
| Geiger-Maor, A | 1 |
| Bolik, J | 1 |
| Schumacher, N | 1 |
| Künzel, S | 1 |
| Baines, JF | 1 |
| Nevo, Y | 1 |
| Elgavish, S | 1 |
| Galun, E | 1 |
| Amsalem, H | 1 |
| Schmidt-Arras, D | 1 |
| Rachmilewitz, J | 1 |
| Ahmed, OM | 1 |
| Ahmed, AA | 1 |
| Fahim, HI | 1 |
| Zaky, MY | 1 |
| Chen, Q | 1 |
| You, X | 1 |
| Jiang, S | 1 |
| Lai, J | 1 |
| Zhang, H | 1 |
| Bai, L | 1 |
| Wakana, H | 1 |
| Kono, H | 1 |
| Fukushima, H | 1 |
| Nakata, Y | 1 |
| Akazawa, Y | 1 |
| Maruyama, S | 1 |
| Hagio, K | 1 |
| Fujii, H | 1 |
| Ichikawa, D | 1 |
| Lee, DY | 1 |
| Yun, SM | 1 |
| Song, MY | 1 |
| Ji, SD | 1 |
| Son, JG | 1 |
| Kim, EH | 1 |
| Ram, AK | 1 |
| Vairappan, B | 1 |
| Srinivas, BH | 1 |
| Alsahli, MA | 1 |
| Almatroodi, SA | 1 |
| Almatroudi, A | 1 |
| Khan, AA | 1 |
| Anwar, S | 1 |
| Almutary, AG | 1 |
| Alrumaihi, F | 1 |
| Rahmani, AH | 1 |
| Helms, TH | 1 |
| Mullins, RD | 1 |
| Thomas-Ahner, JM | 1 |
| Kulp, SK | 1 |
| Campbell, MJ | 1 |
| Lucas, F | 1 |
| Schmidt, N | 1 |
| LeMoine, DM | 1 |
| Getaneh, S | 1 |
| Xie, Z | 1 |
| Phelps, MA | 1 |
| Clinton, SK | 1 |
| Coss, CC | 1 |
| Chen, Z | 1 |
| Han, L | 1 |
| He, X | 1 |
| Cahyani, DM | 1 |
| Miatmoko, A | 1 |
| Hariawan, BS | 1 |
| Purwantari, KE | 1 |
| Sari, R | 1 |
| Mahmoud, AM | 1 |
| Zaki, AR | 1 |
| Hassan, ME | 1 |
| Mostafa-Hedeab, G | 1 |
| Verma, A | 3 |
| Singh, D | 2 |
| Anwar, F | 2 |
| Bhatt, PC | 2 |
| Al-Abbasi, F | 1 |
| Kumar, V | 3 |
| Rahman, M | 1 |
| Al-Abbasi, FA | 1 |
| Bay, ML | 1 |
| Gehl, J | 1 |
| Pedersen, BK | 1 |
| Hojman, P | 1 |
| Pan, LC | 1 |
| Xiao, HY | 1 |
| Yin, WJ | 1 |
| Lin, Z | 1 |
| Robertson, CL | 1 |
| Mendoza, RG | 1 |
| Jariwala, N | 1 |
| Dozmorov, M | 1 |
| Mukhopadhyay, ND | 1 |
| Subler, MA | 1 |
| Windle, JJ | 1 |
| Lai, Z | 1 |
| Fisher, PB | 1 |
| Ghosh, S | 1 |
| Sarkar, D | 1 |
| Singh, M | 1 |
| Yadav, E | 1 |
| Falls, N | 1 |
| Singh Dangi, D | 1 |
| Ramteke, PW | 1 |
| Kaltenecker, D | 1 |
| Themanns, M | 1 |
| Mueller, KM | 1 |
| Spirk, K | 1 |
| Golob-Schwarzl, N | 1 |
| Friedbichler, K | 1 |
| Kenner, L | 1 |
| Haybaeck, J | 3 |
| Moriggl, R | 1 |
| Kessler, SM | 2 |
| Hoppstädter, J | 1 |
| Hosseini, K | 1 |
| Laggai, S | 1 |
| Kiemer, AK | 2 |
| Borst, K | 1 |
| Graalmann, T | 1 |
| Kalinke, U | 1 |
| El-Magd, MA | 1 |
| Mohamed, Y | 1 |
| El-Shetry, ES | 1 |
| Elsayed, SA | 1 |
| Abo Gazia, M | 1 |
| Abdel-Aleem, GA | 1 |
| Shafik, NM | 1 |
| Abdo, WS | 1 |
| El-Desouki, NI | 1 |
| Basyony, MA | 1 |
| Adebayo, OA | 1 |
| Akinloye, O | 1 |
| Adaramoye, OA | 1 |
| Fuentes-Hernández, S | 1 |
| Alarcón-Sánchez, BR | 1 |
| Guerrero-Escalera, D | 1 |
| Montes-Aparicio, AV | 1 |
| Castro-Gil, MP | 1 |
| Idelfonso-García, OG | 1 |
| Rosas-Madrigal, S | 1 |
| Aparicio-Bautista, DI | 1 |
| Pérez-Hernández, JL | 1 |
| Reyes-Gordillo, K | 1 |
| Lakshman, MR | 1 |
| Vásquez-Garzón, VR | 1 |
| Baltiérrez-Hoyos, R | 1 |
| López-González, ML | 1 |
| Sierra-Santoyo, A | 1 |
| Villa-Treviño, S | 1 |
| Pérez-Carreón, JI | 1 |
| Arellanes-Robledo, J | 1 |
| Yan, HX | 1 |
| Wu, HP | 1 |
| Zhang, HL | 1 |
| Ashton, C | 1 |
| Tong, C | 1 |
| Wu, H | 1 |
| Qian, QJ | 1 |
| Wang, HY | 1 |
| Ying, QL | 1 |
| Ip, BC | 1 |
| Hu, KQ | 1 |
| Smith, DE | 1 |
| Obin, MS | 1 |
| Ausman, LM | 1 |
| Wang, XD | 1 |
| Scaiewicz, V | 1 |
| Nahmias, A | 1 |
| Chung, RT | 1 |
| Mueller, T | 1 |
| Tirosh, B | 1 |
| Shibolet, O | 1 |
| Simon, Y | 1 |
| Gemperlein, K | 1 |
| Gianmoena, K | 1 |
| Cadenas, C | 1 |
| Zimmer, V | 1 |
| Pokorny, J | 1 |
| Barghash, A | 1 |
| Helms, V | 1 |
| van Rooijen, N | 1 |
| Bohle, RM | 1 |
| Lammert, F | 1 |
| Hengstler, JG | 1 |
| Mueller, R | 1 |
| Umemura, A | 1 |
| Park, EJ | 1 |
| Taniguchi, K | 1 |
| Lee, JH | 1 |
| Shalapour, S | 1 |
| Valasek, MA | 1 |
| Aghajan, M | 1 |
| Nakagawa, H | 1 |
| Seki, E | 1 |
| Hall, MN | 1 |
| Karin, M | 3 |
| Hatting, M | 1 |
| Spannbauer, M | 1 |
| Peng, J | 1 |
| Al Masaoudi, M | 1 |
| Sellge, G | 1 |
| Nevzorova, YA | 1 |
| Gassler, N | 1 |
| Liedtke, C | 1 |
| Cubero, FJ | 1 |
| Trautwein, C | 1 |
| Wree, A | 1 |
| Johnson, CD | 1 |
| Font-Burgada, J | 1 |
| Eguchi, A | 1 |
| Povero, D | 1 |
| Feldstein, AE | 1 |
| Yang, Y | 1 |
| Guo, Y | 1 |
| Tan, S | 1 |
| Ke, B | 1 |
| Tao, J | 1 |
| Liu, H | 1 |
| Jiang, J | 1 |
| Chen, J | 1 |
| Chen, G | 1 |
| Wu, B | 1 |
| Peng, B | 1 |
| Liu, F | 1 |
| Han, R | 1 |
| Luo, G | 1 |
| Cathopoulis, T | 1 |
| Lu, K | 1 |
| Li, X | 1 |
| Yang, L | 1 |
| Liu, GY | 1 |
| Cai, JC | 1 |
| Shi, SL | 1 |
| Seifert, L | 1 |
| Deutsch, M | 1 |
| Alothman, S | 1 |
| Alqunaibit, D | 1 |
| Werba, G | 1 |
| Pansari, M | 1 |
| Pergamo, M | 1 |
| Ochi, A | 1 |
| Torres-Hernandez, A | 1 |
| Levie, E | 1 |
| Tippens, D | 1 |
| Greco, SH | 1 |
| Tiwari, S | 1 |
| Ly, NNG | 1 |
| Eisenthal, A | 1 |
| van Heerden, E | 1 |
| Avanzi, A | 1 |
| Barilla, R | 1 |
| Zambirinis, CP | 1 |
| Rendon, M | 1 |
| Daley, D | 1 |
| Pachter, HL | 1 |
| Hajdu, C | 1 |
| Miller, G | 1 |
| Miyazaki, T | 1 |
| Shirakami, Y | 1 |
| Kubota, M | 1 |
| Ideta, T | 1 |
| Kochi, T | 1 |
| Sakai, H | 1 |
| Tanaka, T | 1 |
| Moriwaki, H | 1 |
| Shimizu, M | 1 |
| Sharmila, R | 1 |
| Sindhu, G | 1 |
| Arockianathan, PM | 1 |
| Talaat, RM | 1 |
| Adel, S | 1 |
| Salem, TA | 1 |
| Nasr, MI | 1 |
| Yu, C | 1 |
| Yan, S | 1 |
| Khambu, B | 1 |
| Chen, X | 1 |
| Dong, Z | 1 |
| Luo, J | 1 |
| Michalopoulos, GK | 1 |
| Wu, S | 1 |
| Yin, XM | 1 |
| Yamada, K | 1 |
| Mito, F | 1 |
| Matsuoka, Y | 1 |
| Ide, S | 1 |
| Shikimachi, K | 1 |
| Fujiki, A | 1 |
| Kusakabe, D | 1 |
| Ishida, Y | 1 |
| Enoki, M | 1 |
| Tada, A | 1 |
| Ariyoshi, M | 1 |
| Yamasaki, T | 1 |
| Yamato, M | 1 |
| Shalini, S | 1 |
| Nikolic, A | 1 |
| Wilson, CH | 1 |
| Puccini, J | 1 |
| Sladojevic, N | 1 |
| Finnie, J | 1 |
| Dorstyn, L | 1 |
| Kumar, S | 1 |
| Chi, HC | 1 |
| Chen, SL | 1 |
| Tsai, CY | 1 |
| Chuang, WY | 1 |
| Huang, YH | 1 |
| Tsai, MM | 1 |
| Wu, SM | 1 |
| Sun, CP | 1 |
| Yeh, CT | 1 |
| Lin, KH | 1 |
| Hanna, D | 1 |
| Riedmaier, AE | 1 |
| Sugamori, KS | 1 |
| Grant, DM | 1 |
| Baginskaya, NV | 1 |
| Il'nitskaya, SI | 1 |
| Nikitenko, EV | 1 |
| Kaledin, VI | 1 |
| Bishayee, A | 4 |
| Waghray, A | 1 |
| Barnes, KF | 2 |
| Mbimba, T | 1 |
| Bhatia, D | 4 |
| Chatterjee, M | 1 |
| Darvesh, AS | 4 |
| Carroll, RT | 1 |
| Stärkel, P | 1 |
| Charette, N | 1 |
| Borbath, I | 1 |
| Schneider-Merck, T | 1 |
| De Saeger, C | 1 |
| Abarca, J | 1 |
| Leclercq, I | 1 |
| Horsmans, Y | 1 |
| Thoppil, RJ | 2 |
| Mandal, A | 1 |
| Ohanyan, V | 2 |
| Meszaros, JG | 2 |
| Háznagy-Radnai, E | 1 |
| Hohmann, J | 1 |
| Maeda, S | 1 |
| Kamata, H | 1 |
| Luo, JL | 1 |
| Leffert, H | 1 |
| Finnberg, N | 1 |
| Klein-Szanto, AJ | 1 |
| El-Deiry, WS | 1 |
| Elpek, GO | 1 |
| Gokhan, GA | 1 |
| Bozova, S | 1 |
| Liao, WS | 1 |
| Ma, KT | 1 |
| Becker, FF | 1 |
| Nadal, C | 1 |
| Valéro, D | 1 |
| Périn, F | 1 |
63 other studies available for diethylnitrosamine and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Farnesol; Inflammation; Liver; | 2021 |
Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diet, High-Fat; Diethylni | 2021 |
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamin | 2021 |
Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Topics: Alcohol Drinking; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinogenes | 2022 |
Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; Fruit; Gene Ex | 2021 |
Ethanol supernatant extracts of Gynura procumbens could treat nanodiethylnitrosamine-induced mouse liver cancer by interfering with inflammatory factors for the tumor microenvironment.
Topics: Animals; Antineoplastic Agents, Phytogenic; Asteraceae; Diethylnitrosamine; Drugs, Chinese Herbal; E | 2022 |
Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation.
Topics: Animals; Apoptosis; Body Weight; Cell Cycle; Cell Proliferation; Cytokines; Diethylnitrosamine; Doco | 2021 |
Pueraria montana (Kudzu vine) Ameliorate the Inflammation and Oxidative Stress against Fe-NTA Induced Renal Cancer.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Body Weight; Creatinine; Cyclooxygenase 2; Diethylnitrosam | 2022 |
Hepatoprotective effects of aspirin on diethylnitrosamine-induced hepatocellular carcinoma in rats by reducing inflammation levels and PD-L1 expression.
Topics: Animals; Aspirin; B7-H1 Antigen; Carcinoma, Hepatocellular; Diethylnitrosamine; Inflammation; Liver | 2023 |
The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract.
Topics: Animals; Carcinogens; Cell Proliferation; Colon; Diethylnitrosamine; Inflammation; Liver; Male; Oxid | 2019 |
Gut microbiota shape 'inflamm-ageing' cytokines and account for age-dependent decline in DNA damage repair.
Topics: Aging; Animals; Anti-Bacterial Agents; Cytokines; Diethylnitrosamine; Disease Models, Animal; DNA Da | 2020 |
Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Diethylnitrosamine; Flavanones; Inflammation; Liver; Male | 2022 |
Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Inflammation; Liver; | 2020 |
Effects of Medium-chain Triglycerides Administration in Chemically-induced Carcinogenesis in Mice.
Topics: 3-Hydroxybutyric Acid; Adipocytes; Adipokines; Adiponectin; Adipose Tissue; Aldehydes; Animal Feed; | 2019 |
Administration of Steamed and Freeze-Dried Mature Silkworm Larval Powder Prevents Hepatic Fibrosis and Hepatocellular Carcinogenesis by Blocking TGF-β/STAT3 Signaling Cascades in Rats.
Topics: Animals; Bombyx; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; | 2020 |
Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Inflammation; Limonins; Live | 2020 |
6-Gingerol, a Major Ingredient of Ginger Attenuates
Topics: Albumins; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Catechols; Chemical and Drug Induce | 2021 |
Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks.
Topics: Androgens; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; | 2021 |
Optimized protocol for an inducible rat model of liver tumor with chronic hepatocellular injury, inflammation, fibrosis, and cirrhosis.
Topics: Animals; Carcinogenesis; Diethylnitrosamine; Humans; Inflammation; Liver Cirrhosis, Experimental; Li | 2021 |
N-nitrosodiethylamine induces inflammation of liver in mice.
Topics: Animals; Body Weight; Diethylnitrosamine; Inflammation; Liver; Liver Neoplasms, Experimental; Mice; | 2021 |
Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Heme Oxygenase-1; Inflammat | 2017 |
Triterpenoids principle of Wedelia calendulacea attenuated diethynitrosamine-induced hepatocellular carcinoma via down-regulating oxidative stress, inflammation and pathology via NF-kB pathway.
Topics: Animals; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Diethylnit | 2018 |
Umbelliferon-α-d-glucopyranosyl-(2
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Proliferation; Cytok | 2017 |
Voluntary Wheel Running Reduces the Acute Inflammatory Response to Liver Carcinogen in a Sex-specific Manner.
Topics: Acute Disease; Animals; Carcinogens; Carcinoma, Hepatocellular; Choice Behavior; Diethylnitrosamine; | 2017 |
Correlation between HSD17B4 expression in rat liver cancer tissues and inflammation or proliferation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Estradiol; Extracellular | 2018 |
Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Move | 2018 |
Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles.
Topics: Animals; Antioxidants; Apocynaceae; Biomarkers, Tumor; Diethylnitrosamine; Down-Regulation; Female; | 2018 |
STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytokines; Diethylni | 2019 |
Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation.
Topics: Diethylnitrosamine; Hepatitis; Humans; Inflammation; Kupffer Cells; Liver; Receptor, Interferon alph | 2019 |
Reply to: "Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation".
Topics: Diethylnitrosamine; Hepatitis; Humans; Inflammation; Kupffer Cells; Receptor, Interferon alpha-beta | 2019 |
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Topics: alpha-Fetoproteins; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2019 |
Cerium Oxide Nanoparticles Attenuate Oxidative Stress and Inflammation in the Liver of Diethylnitrosamine-Treated Mice.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Inflammation; Liver; Ma | 2020 |
Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Drug Syn | 2019 |
p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release.
Topics: Animals; Cell Line; Diethylnitrosamine; Gene Knockout Techniques; Genes, p53; Hepatitis, Chronic; HM | 2013 |
Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Carotenoids; Ce | 2013 |
CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model.
Topics: Active Transport, Cell Nucleus; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Nucleus; Di | 2013 |
Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease M | 2014 |
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cell T | 2014 |
Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model.
Topics: Animals; Carcinoma, Hepatocellular; Cytokine Receptor gp130; Diethylnitrosamine; DNA Damage; Female; | 2015 |
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel | 2015 |
β-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling.
Topics: Alkylating Agents; Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Blotting, W | 2015 |
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chemical and | 2015 |
Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chemokine CCL2; Cytokines; Diethylnitrosa | 2015 |
Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.
Topics: Alginates; Animals; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Diethylnitrosa | 2016 |
Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats.
Topics: Animals; Antioxidants; Biomarkers; Diethylnitrosamine; Ferric Compounds; Inflammation; Kidney; Lipid | 2016 |
Correlation between angiogenic/inflammatory mediators in Wister rat model of liver dysplasia.
Topics: Animals; Cyclooxygenase 2; Diethylnitrosamine; Disease Models, Animal; Enzyme-Linked Immunosorbent A | 2016 |
Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carcinogenesis; Carcinoma, Hepatocellular; Ce | 2016 |
Fluorescence probes to detect lipid-derived radicals.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Apoptosis; Cell Line, Tumor; Cyclic N-Oxides; Diethylnitrosam | 2016 |
Caspase-2 deficiency accelerates chemically induced liver cancer in mice.
Topics: Animals; Carcinoma, Hepatocellular; Caspase 2; Cell Death; Cell Proliferation; Diethylnitrosamine; D | 2016 |
Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
Topics: Animals; Autophagy; Carcinogenesis; Carcinoma, Hepatocellular; Death-Associated Protein Kinases; Die | 2016 |
Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
Topics: Aging; Alanine Transaminase; Aminobiphenyl Compounds; Animals; Animals, Newborn; Carbon Tetrachlorid | 2016 |
Promoting effect of o-aminoazotoluene on hepatocarcinogenesis is accompanied by the increase in inflammatory and proliferative processes in liver tissue and decrease in the concentration of free thyroxin in the blood.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Female; Inf | 2007 |
Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Chemoprevention; Cyclooxygenase 2; Diethylnitrosamine; Female; HSP | 2010 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose | 2010 |
Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Cycle; Cell Proliferation; Cyclin D; Diethylnitr | 2012 |
Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response.
Topics: Alkylating Agents; Animals; Anthocyanins; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic | 2013 |
Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; E | 2013 |
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.
Topics: Animals; Carcinogens; Cell Death; Cell Proliferation; Cell Transformation, Neoplastic; Cytokines; Di | 2005 |
TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis.
Topics: Alkylating Agents; Animals; Bronchitis; Cell Line, Tumor; Cell Transformation, Neoplastic; Chronic D | 2008 |
Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis.
Topics: Animals; Antigens, CD34; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Gene Expression Regul | 2008 |
Altered expression of acute-phase reactants in mouse liver tumors.
Topics: Acute-Phase Proteins; Animals; Blotting, Northern; Diethylnitrosamine; DNA; DNA Probes; DNA, Neoplas | 1989 |
[Stimulation, by acute inflammation, of the proliferation in preneoplastic hepatocyte foci expressing the gamma glutamyl transpeptidase, induced by diethylnitrosamine in adult rats].
Topics: Acute Disease; Animals; Caseins; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Infla | 1988 |