diethylnitrosamine has been researched along with Hyperplasia in 96 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Excerpt | Relevance | Reference |
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"In previous studies, we demonstrated that pulmonary neuroendocrine cell (PNEC) hyperplasia in hamsters treated with diethylnitrosamine (DEN) plus 65% hyperoxia (DEN/O2) reflects predominantly neuroendocrine cell differentiation." | 7.70 | CD10/neutral endopeptidase inhibition augments pulmonary neuroendocrine cell hyperplasia in hamsters treated with diethylnitrosamine and hyperoxia. ( Graham, SA; Shahsafei, A; Sunday, ME; Willett, CG, 1999) |
" In this study we report that gavage administration of 200 mg/kg or 600 mg/kg CCM effectively suppressed diethylnitrosamine (DEN)-induced liver inflammation and hyperplasia in rats, as evidenced by histopathological examination." | 7.70 | Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. ( Cheng, AL; Chuang, SE; Kuo, ML; Lin, JK, 2000) |
"The promoting effect of NaCl solution mist was studied in the induction of papillomas on Syrian hamster trachea following single subcutaneous injection of diethylnitrosamine (DEN)." | 7.68 | Promoting effect of sodium chloride solution mist on the induction of papillomas on Syrian hamster tracheal mucosa following administration of diethylnitrosamine. ( Karube, T; Katayama, H; Takemoto, K; Watanabe, S, 1991) |
" It has been demonstrated that hyperplasia of hamster lung endocrine cells occurs following exposure to diethylnitrosamine (DEN), a systemic carcinogen." | 7.67 | Calcitonin as a marker for diethylnitrosamine-induced pulmonary endocrine cell hyperplasia in hamsters. ( Becker, KL; Linnoila, RI; Moore, CF; Silva, OL; Snider, RH, 1984) |
"In 28 tumor bearing chimeric mice, all squamous cell carcinomas (SCCs) were composed entirely of either CSA positive or negative tumor cells." | 5.29 | Monoclonal development of squamous cell carcinomas from polyclonal papillary or nodular hyperplasias in the forestomach of C3H/HeN<-->BALB/c chimeric mice treated with N-methyl-N-nitrosourea or diethylnitrosamine. ( Fujimitsu, Y; Fukami, H; Inada, K; Kusakabe, M; Masui, T; Nakanishi, H; Tatematsu, M; Yamamoto, M, 1996) |
"To induce chronic cholestasis, Balb/c mice were given 2 weekly intraperitoneal injections of diethylnitrosamine (DEN); 2 weeks later, some mice also received left and median bile duct ligation (LMBDL) and, then 1 week later, were fed DEN, in corn oil, weekly by oral gavage (DLD)." | 3.77 | A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression. ( Aller, MA; Ko, KS; Li, TW; Peng, J; Tang, X; Xia, M; Yang, H, 2011) |
" Furthermore, Shp2 ablation dramatically enhanced diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) development, which was abolished by concurrent deletion of Shp2 and Stat3 in hepatocytes." | 3.77 | Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. ( Bailly-Maitre, B; Bard-Chapeau, EA; Ding, J; Fang, DD; Feng, GS; Han, T; Li, S; Poli, V; Princen, F; Varki, NM; Wang, H; Zhang, SS; Zhu, HH, 2011) |
"GABAergic alterations in hypothalamus during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN) induced direct hyperplasia and N-nitrosodiethylamine (NDEA) induced neoplasia in liver were investigated." | 3.71 | Hypothalamic GABA receptor functional regulation and liver cell proliferation. ( Biju, MP; Paulose, CS; Pyroja, S; Rajeshkumar, NV, 2001) |
"In previous studies, we demonstrated that pulmonary neuroendocrine cell (PNEC) hyperplasia in hamsters treated with diethylnitrosamine (DEN) plus 65% hyperoxia (DEN/O2) reflects predominantly neuroendocrine cell differentiation." | 3.70 | CD10/neutral endopeptidase inhibition augments pulmonary neuroendocrine cell hyperplasia in hamsters treated with diethylnitrosamine and hyperoxia. ( Graham, SA; Shahsafei, A; Sunday, ME; Willett, CG, 1999) |
" In this study we report that gavage administration of 200 mg/kg or 600 mg/kg CCM effectively suppressed diethylnitrosamine (DEN)-induced liver inflammation and hyperplasia in rats, as evidenced by histopathological examination." | 3.70 | Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. ( Cheng, AL; Chuang, SE; Kuo, ML; Lin, JK, 2000) |
"Intense pulmonary neuroendocrine cell (PNEC) hyperplasia occurs during preneoplastic lung injury in hamsters treated with diethylnitrosamine (DEN) plus hyperoxia." | 3.69 | Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia. ( Graham, SA; Patidar, K; Sunday, ME; Willett, CG, 1994) |
"Two-stage carcinogenesis of mouse skin papillomas induced by 7,12-dimethylbenz[alpha]anthracene and 12-O-tetradecanoylphorbol 13-acetate, and mouse hepatic tumors induced by N-nitrosodiethylamine and phenobarbital, were inhibited by lantadenes." | 3.69 | Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors. ( Inada, A; Nakanishi, T; Nishino, H; Sharma, OP; Tokuda, H, 1997) |
"The promoting effect of NaCl solution mist was studied in the induction of papillomas on Syrian hamster trachea following single subcutaneous injection of diethylnitrosamine (DEN)." | 3.68 | Promoting effect of sodium chloride solution mist on the induction of papillomas on Syrian hamster tracheal mucosa following administration of diethylnitrosamine. ( Karube, T; Katayama, H; Takemoto, K; Watanabe, S, 1991) |
" Animals were given a single dose of diethylnitrosamine (100 mg/kg body weight)." | 3.68 | Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci. ( Chelo, A; Columbano, A; Curto, M; Ennas, MG; Ledda-Columbano, GM; Pani, P, 1990) |
"05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
"Carcinomas developed in the mucosa of the esophagus in BUF strain rats ingesting diethylnitrosamine in the diet." | 3.65 | Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine. ( Reuber, MD, 1977) |
"HAM-6 was also slightly reactive to rat hepatocellular carcinoma, but not to normal or fetal rat liver, other normal rat organs, human hepatocellular carcinoma, or human liver cirrhosis." | 1.29 | Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens. ( Kurokawa, F, 1994) |
" We conclude that long term intake of BC could reduce cancer risk by preventing hepatic lipid peroxidation and RBC membrane protein damage due to its antioxidant actions." | 1.29 | Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis. ( Bishayee, A; Chatterjee, M; Sarkar, A, 1995) |
"In 28 tumor bearing chimeric mice, all squamous cell carcinomas (SCCs) were composed entirely of either CSA positive or negative tumor cells." | 1.29 | Monoclonal development of squamous cell carcinomas from polyclonal papillary or nodular hyperplasias in the forestomach of C3H/HeN<-->BALB/c chimeric mice treated with N-methyl-N-nitrosourea or diethylnitrosamine. ( Fujimitsu, Y; Fukami, H; Inada, K; Kusakabe, M; Masui, T; Nakanishi, H; Tatematsu, M; Yamamoto, M, 1996) |
"d-Limonene treatment alone caused a significant increase in the number of atypical tubules and atypical hyperplasias in F344 rats when compared with the F344 vehicle control." | 1.28 | The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. ( Dietrich, DR; Swenberg, JA, 1991) |
"Phenobarbital (PB) is an effective growth stimulator of hepatic hyperplastic nodules developed with diethylnitrosamine and 2-acetylaminofluorene plus partial hepatectomy (the Solt-Farber model), but it does not apparently stimulate the growth of preneoplastic lesions produced with aflatoxin B1 (AFB)." | 1.28 | Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats. ( Chen, ZY; Eaton, DL, 1991) |
"In diethylnitrosamine (DEN)-treated rats, which were fed a N-2-fluorenylacetamide (FAA)-containing diet and additionally treated with repeated CCl4 injections, gamma-glutamyl transpeptidase (gamma-GTP)-positive hyperplastic nodules were markedly developed in the 8th week of the experiment." | 1.27 | Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma. ( Sakata, T, 1984) |
"Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
"Diethylnitrosamine was used as initiating agent of hepatocarcinogenesis and lipid peroxidation levels were monitored in the homogenates from normal liver, hyperplastic nodules and tumour, incubated in the presence or in the absence of ascorbate or adenosine diphosphate-iron complex." | 1.27 | Resistance to oxidative stress by hyperplastic and neoplastic rat liver tissue monitored in terms of production of unpolar and medium polar carbonyls. ( Biasi, F; Biocca, ME; Canuto, RA; Cecchini, G; Chiarpotto, E; Dianzani, MU; Esterbauer, H; Muzio, G; Poli, G, 1986) |
"Neuroendocrine lung cancer is among the most common types of lung tumor in man and demonstrates a strong etiological association with cigarette smoking." | 1.27 | An animal model for neuroendocrine lung cancer. ( Becker, KL; Schuller, HM; Witschi, HP, 1988) |
"Using the Solt and Farber model (Nature, 263 (1976) 701), dose-response relationships between initiating agents and the induction of hyperplastic nodules in rat liver were investigated." | 1.26 | Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis. ( Imaida, K; Ito, N; Shirai, T; Takano, T; Tatematsu, M, 1981) |
" Dose-response relationships measured with diethylnitrosamine, the carcinogen with the lowest toxicity as compared with the carcinogenic action, indicated that island formation is due to a one-hit process, i." | 1.26 | Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis. ( Emmelot, P; Scherer, E, 1976) |
"The pulmonary metastases were first detected in mice dying between 51 and 60 weeks of age (5%)." | 1.26 | Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice. ( Mihailovich, N; Rao, KV; Vesselinovitch, SD, 1978) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 54 (56.25) | 18.7374 |
1990's | 33 (34.38) | 18.2507 |
2000's | 3 (3.13) | 29.6817 |
2010's | 6 (6.25) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Das, T | 1 |
Patra, F | 1 |
Mukherjee, B | 1 |
Bishayee, A | 2 |
Barnes, KF | 1 |
Bhatia, D | 1 |
Darvesh, AS | 1 |
Carroll, RT | 1 |
Kowalik, MA | 1 |
Saliba, C | 1 |
Pibiri, M | 1 |
Perra, A | 1 |
Ledda-Columbano, GM | 4 |
Sarotto, I | 1 |
Ghiso, E | 1 |
Giordano, S | 1 |
Columbano, A | 4 |
Yang, H | 1 |
Li, TW | 1 |
Peng, J | 1 |
Tang, X | 1 |
Ko, KS | 1 |
Xia, M | 1 |
Aller, MA | 1 |
Bard-Chapeau, EA | 1 |
Li, S | 1 |
Ding, J | 1 |
Zhang, SS | 1 |
Zhu, HH | 1 |
Princen, F | 1 |
Fang, DD | 1 |
Han, T | 1 |
Bailly-Maitre, B | 1 |
Poli, V | 1 |
Varki, NM | 1 |
Wang, H | 1 |
Feng, GS | 1 |
Yuan, F | 1 |
Lu, J | 1 |
You, P | 1 |
Yang, Z | 1 |
Yang, P | 1 |
Ma, Q | 1 |
Tao, T | 1 |
Deml, E | 1 |
Oesterle, D | 1 |
Kleinerman, J | 2 |
Marchevsky, AM | 2 |
Thornton, J | 1 |
Pereira, MA | 1 |
Savage, RE | 1 |
Herren, SL | 1 |
Guion, CW | 1 |
Ogawa, K | 4 |
Yokokawa, K | 1 |
Tomoyori, T | 1 |
Onoé, T | 1 |
Vinarchuk, MP | 3 |
Kononenko, LI | 2 |
Bykorez, AI | 3 |
Smith, GJ | 1 |
DeLuca, CM | 1 |
Yong, LC | 1 |
Gel'shteĭn, VI | 1 |
Chipysheva, TA | 1 |
Bannikov, GA | 1 |
Sakata, T | 1 |
Kitahara, A | 1 |
Yamazaki, T | 1 |
Ishikawa, T | 2 |
Camba, EA | 1 |
Sato, K | 2 |
Linnoila, RI | 1 |
Becker, KL | 2 |
Silva, OL | 1 |
Snider, RH | 1 |
Moore, CF | 1 |
Ogawa, H | 3 |
Itoshima, T | 2 |
Ukida, M | 2 |
Ito, T | 3 |
Kiyotoshi, S | 2 |
Kitadai, M | 2 |
Hattori, S | 2 |
Mizutani, S | 2 |
Kita, K | 1 |
Tanaka, R | 1 |
Imaida, K | 6 |
Shirai, T | 3 |
Tatematsu, M | 7 |
Takano, T | 2 |
Ito, N | 9 |
Yin, Z | 1 |
Tsuda, H | 4 |
Kawaguchi, K | 1 |
Tobe, K | 1 |
Nagashima, H | 1 |
Kobayashi, T | 1 |
Ward, JM | 3 |
Rice, JM | 1 |
Creasia, D | 1 |
Lynch, P | 1 |
Riggs, C | 1 |
Hasegawa, R | 5 |
Nakanishi, K | 3 |
Okuda, K | 1 |
Kagawa, K | 1 |
Kitamura, O | 1 |
Tomimasu, H | 1 |
Takahashi, T | 1 |
Takino, T | 1 |
Ashihara, T | 1 |
Ogiso, T | 1 |
Cameron, R | 1 |
Wanson, JC | 1 |
Penasse, W | 1 |
Bernaert, D | 1 |
May, C | 1 |
Murasaki, G | 2 |
Degawa, M | 2 |
Miura, S | 2 |
Yoshinari, K | 1 |
Hashimoto, Y | 2 |
Richards, RJ | 1 |
Xu, X | 1 |
Ruan, YB | 1 |
Wu, ZB | 1 |
Sunday, ME | 4 |
Willett, CG | 4 |
Patidar, K | 1 |
Graham, SA | 2 |
Matsumoto, K | 1 |
Iwase, T | 1 |
Nishida, Y | 1 |
Baba, H | 1 |
Kurokawa, F | 1 |
Puapairoj, P | 1 |
Cui, L | 1 |
Akagi, K | 1 |
Nowak, C | 1 |
Gleier, K | 1 |
Christ, M | 1 |
Gorzelniak, K | 1 |
Richter-Reichhelm, HB | 2 |
Aze, Y | 1 |
Toyoda, K | 1 |
Furukawa, F | 2 |
Mitsumori, K | 2 |
Takahashi, M | 4 |
Sarkar, A | 1 |
Chatterjee, M | 1 |
Yamamoto, T | 1 |
Kaneda, K | 1 |
Hirohashi, K | 1 |
Kinoshita, H | 1 |
Sakurai, M | 1 |
Masui, T | 1 |
Fukami, H | 1 |
Yamamoto, M | 1 |
Nakanishi, H | 1 |
Inada, K | 1 |
Fujimitsu, Y | 1 |
Kusakabe, M | 1 |
Wu, CG | 1 |
Hoek, FJ | 1 |
Groenink, M | 1 |
Reitsma, PH | 1 |
van Deventer, SJ | 1 |
Chamuleau, RA | 1 |
Inada, A | 1 |
Nakanishi, T | 1 |
Tokuda, H | 1 |
Nishino, H | 1 |
Sharma, OP | 1 |
Hirose, M | 1 |
Yamaguchi, T | 1 |
Kimoto, N | 1 |
Futakuchi, M | 1 |
Sano, M | 1 |
Shahsafei, A | 1 |
Song, KY | 2 |
Lim, IK | 2 |
Park, SC | 2 |
Lee, SO | 1 |
Park, HS | 1 |
Choi, YK | 1 |
Hyun, BH | 2 |
Park, TJ | 1 |
Lee, MS | 1 |
Kim, SJ | 1 |
Chuang, SE | 1 |
Cheng, AL | 1 |
Lin, JK | 1 |
Kuo, ML | 1 |
Biju, MP | 1 |
Pyroja, S | 1 |
Rajeshkumar, NV | 1 |
Paulose, CS | 1 |
Balansky, RM | 1 |
Ganchev, G | 1 |
D'Agostini, F | 1 |
De Flora, S | 1 |
Pitot, HC | 1 |
Miyata, Y | 2 |
Shinohara, Y | 2 |
Scherer, E | 1 |
Emmelot, P | 1 |
Rubenchik, BL | 1 |
Romanenko, AM | 1 |
Solt, DB | 1 |
Hay, JB | 1 |
Farber, E | 2 |
Takayama, S | 1 |
Pyllvere, EI | 1 |
Vesselinovitch, SD | 1 |
Mihailovich, N | 1 |
Rao, KV | 1 |
Medline, A | 1 |
Emura, M | 1 |
Mohr, U | 1 |
Reuber, MD | 1 |
Coni, P | 2 |
Curto, M | 2 |
Giacomini, L | 1 |
Faa, G | 1 |
Sarma, DS | 1 |
Hiasa, Y | 3 |
Konishi, N | 3 |
Nakaoka, S | 2 |
Nakamura, T | 1 |
Nishii, K | 1 |
Ohshima, M | 2 |
Okamiya, H | 1 |
Shinoda, K | 1 |
Yoshimura, H | 1 |
Hayashi, Y | 2 |
Amanuma, T | 1 |
Mizumoto, K | 1 |
Tsutsumi, M | 2 |
Tsujiuchi, T | 1 |
Kitazawa, S | 1 |
Hasegawa, K | 1 |
Denda, A | 2 |
Maruyama, H | 1 |
Konishi, Y | 2 |
Dietrich, DR | 1 |
Swenberg, JA | 1 |
Nakamura, M | 1 |
Nishii, S | 1 |
Kitahori, Y | 2 |
Karube, T | 1 |
Katayama, H | 1 |
Takemoto, K | 1 |
Watanabe, S | 1 |
Xie, YJ | 1 |
Chen, ZY | 1 |
Eaton, DL | 1 |
Ennas, MG | 1 |
Chelo, A | 1 |
Pani, P | 2 |
Shimoji, N | 1 |
Matsuoka, C | 1 |
Uneyama, CT | 1 |
Kemp, CJ | 1 |
Drinkwater, NR | 1 |
Alison, MR | 1 |
Rehm, S | 1 |
Singh, G | 2 |
Katyal, SL | 2 |
Henneman, JR | 1 |
Comolli, R | 1 |
Alberti, P | 1 |
Giribaldi, G | 1 |
Huntrakoon, M | 1 |
Menon, CD | 1 |
Hung, KS | 1 |
Canuto, RA | 2 |
Biocca, ME | 2 |
Muzio, G | 2 |
Dianzani, MU | 2 |
Greaves, P | 1 |
Irisarri, E | 1 |
Monro, AM | 1 |
Liguori, C | 1 |
Ura, H | 1 |
Yokose, Y | 1 |
Kitamura, H | 1 |
Inayama, Y | 1 |
Kanisawa, M | 1 |
Poli, G | 1 |
Cecchini, G | 1 |
Biasi, F | 1 |
Chiarpotto, E | 1 |
Esterbauer, H | 1 |
Schuller, HM | 1 |
Witschi, HP | 1 |
Estadella, MD | 1 |
Pujol, MJ | 1 |
Domingo, J | 1 |
Harada, T | 1 |
Enomoto, A | 1 |
Kitazawa, T | 1 |
Maita, K | 1 |
Shirasu, Y | 1 |
Yamada, K | 1 |
Tsukidate, K | 1 |
Taki, T | 1 |
Katayama, K | 1 |
Sato, T | 1 |
Gulich, MP | 1 |
Anderson, LM | 1 |
Kovatch, RM | 1 |
Shimoyama, T | 1 |
2 reviews available for diethylnitrosamine and Hyperplasia
Article | Year |
---|---|
[Early histochemical markers of hepatocarcinogenesis].
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; alpha-Fetoproteins; Animals; Diethylnitrosamine; g | 1984 |
Regulation of hepatic growth.
Topics: Alpha-Globulins; Animals; Carbon Tetrachloride Poisoning; Cell Cycle; Cell Division; Cyclic AMP; Die | 1986 |
94 other studies available for diethylnitrosamine and Hyperplasia
Article | Year |
---|---|
Effect of antisense oligomer in controlling c-raf.1 overexpression during diethylnitrosamine-induced hepatocarcinogenesis in rat.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Transformation, Neoplastic; Cytochrome P-45 | 2010 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose | 2010 |
Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell | 2011 |
A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic Helix-Loop-Helix Transcr | 2011 |
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Gene Express | 2011 |
Proteomic profiling of expression of proteasomal subunits from livers of mice treated with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Electrophoresis, Gel, Two-Dimensional; Histocytochemistry; Hyperplasia; | 2013 |
Histochemical demonstration of enhanced glutathione content in enzyme-altered islands induced by carcinogens in rat liver.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glutathio | 1980 |
Quantitative studies of APUD cells in airways of rats. The effects of diethylnitrosamine and NO2.
Topics: Animals; APUD Cells; Cell Count; Diethylnitrosamine; Epithelial Cells; Hyperplasia; Nitrogen Dioxide | 1981 |
Comparison of enhancement of GGTase-positive foci and induction of ornithine decarboxylase in rat liver by barbiturates.
Topics: Animals; Barbiturates; Biotransformation; Carboxy-Lyases; Cocarcinogenesis; Diethylnitrosamine; Enzy | 1982 |
Induction of gamma-glutamyltranspeptidase-positive altered hepatocytic lesions by combination of transplacental-initiation and postanal-selection.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diethylnitrosamine; E | 1982 |
Immunocytochemical studies of APUD cells in airways: effects of nitrosodiethylamine and nitrogen dioxide.
Topics: Animals; APUD Cells; Diethylnitrosamine; Hyperplasia; Immunoenzyme Techniques; Nitrogen Dioxide; Nit | 1982 |
[Histochemical appearance of gamma-glutamyltranspeptidase in the rat liver after transplacental exposure to diethylnitrosamine and postnatal administration of phenobarbital].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Histo | 1984 |
A model of bile duct hyperplasia in the rat induced by diethylnitrosamine and selective cytotoxicity.
Topics: Animals; Bile Duct Diseases; Cystic Duct; Diethylnitrosamine; gamma-Glutamyltransferase; Hyperplasia | 1984 |
[Evolution of hyperplastic foci in the rat liver induced by diethylnitrosamine].
Topics: alpha-Fetoproteins; Animals; Diethylnitrosamine; Glutathione Transferase; Hyperplasia; Immunoenzyme | 1984 |
Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1984 |
Changes in activities of glutathione peroxidase and glutathione reductase during chemical hepatocarcinogenesis in the rat.
Topics: Animals; Diethylnitrosamine; Glutathione Peroxidase; Glutathione Reductase; Hydrogen Peroxide; Hyper | 1983 |
Calcitonin as a marker for diethylnitrosamine-induced pulmonary endocrine cell hyperplasia in hamsters.
Topics: Animals; Calcitonin; Cricetinae; Diethylnitrosamine; Endocrine Glands; Hyperplasia; Lung; Male; Meso | 1984 |
Scanning electron microscopy of experimentally induced sequential alterations of rat liver hyperplastic nodules.
Topics: Animals; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Microscopy, El | 1984 |
Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Diethylnitrosamine; Dimethyln | 1981 |
Changes in activities of uridine diphosphate-glucuronyltransferases during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxyanisole; Diethylnitrosamine; Enzyme Induction; Gluc | 1982 |
Absence of Kupffer cells in carcinogen induced liver hyperplastic nodules: demonstration by intravenous injection of indian ink.
Topics: Animals; Carbon; Coloring Agents; Diethylnitrosamine; Hyperplasia; Injections, Intravenous; Kupffer | 1983 |
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplas | 1983 |
Route-dependent, organ-specific effects of carcinogens on induction of hyperplastic liver nodules in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hyperplasia; Liver; Male; Methyldim | 1982 |
Scanning electron microscopy of rat liver hyperplastic nodules induced by diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Hyperplasia; Liver; Male; Microscopy, Electron; Microscopy, Electron, S | 1982 |
[Cell proliferation analysis of hyperplastic lesions during the liver carcinogenesis in rats by dietylnitrosamine as studied by 3H-thymidine autoradiography (author's transl)].
Topics: Animals; Autoradiography; Cell Division; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Ma | 1981 |
The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Drug Evaluation, Preclinical; Enzyme Induction; | 1980 |
Promotive effects of ethinyl estradiol in hepatocarcinogenesis initiated by diethylnitrosamine in male rats.
Topics: Animals; Diethylnitrosamine; Drug Synergism; Ethinyl Estradiol; Hyperplasia; Liver Neoplasms; Male; | 1981 |
SEM study of adult rat hepatocytes from preneoplastic and hyperplastic foci induced in the liver by diethylnitrosamine.
Topics: Animals; Cell Membrane; Diethylnitrosamine; Disease Models, Animal; Female; Hyperplasia; Liver; Live | 1980 |
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia; | 1980 |
Altered expression of hepatic CYP1A enzymes in rat hepatocarcinogenesis.
Topics: Animals; Base Sequence; Blotting, Northern; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 E | 1995 |
Networks controlling pneumocyte proliferation. Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Division; Cricetinae; Diethylnitrosamine; Disease M | 1994 |
Study on the role of mast cells in the development of liver fibrosis during diethylnitrosamine (DEN) -induced hepatocarcinogenesis in rats.
Topics: Animals; Diethylnitrosamine; Fibroblasts; Hyperplasia; Liver; Liver Cirrhosis, Experimental; Male; M | 1994 |
Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia.
Topics: Animals; Base Sequence; Carcinogens; Cell Differentiation; Cell Division; Cricetinae; Diethylnitrosa | 1994 |
Enhanced neoplastic lesion development with adenine-induced experimental multicystic nephropathy by adenine--a model system for the analysis of renal tumor generation in long-term hemodialysis patients.
Topics: Adenine; Adenoma; Animals; Diethylnitrosamine; Epithelium; Hyperplasia; Kidney Diseases; Kidney Neop | 1994 |
Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellula | 1994 |
Effect of ethanol on paraquat toxicity in F344 rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Ethanol; Glutathione Transferas | 1994 |
Effects of nitroso compounds and aromatic amines on fetal tracheal explants.
Topics: Animals; Cricetinae; Diethylnitrosamine; Hyperplasia; Mesocricetus; Metaplasia; Methylnitronitrosogu | 1993 |
Enhancing effect of ethanol on esophageal tumor development in rats by initiation of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Esophageal Neoplasms; Esophagus; Ethanol; Hyperplasia | 1993 |
Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; beta Carotene; Carcinogens; Carotenoids; Cytosol; Di | 1995 |
Sinusoidal capillarization and arterial blood supply continuously proceed with the advance of the stages of hepatocarcinogenesis in the rat.
Topics: Animals; Capillaries; Carcinoma, Hepatocellular; Diethylnitrosamine; Factor VIII; Hyperplasia; Liver | 1996 |
Monoclonal development of squamous cell carcinomas from polyclonal papillary or nodular hyperplasias in the forestomach of C3H/HeN<-->BALB/c chimeric mice treated with N-methyl-N-nitrosourea or diethylnitrosamine.
Topics: Animals; Antibody Specificity; Carcinogens; Carcinoma, Squamous Cell; Carrier Proteins; Chimera; Die | 1996 |
Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis.
Topics: Aged; Animals; Carcinogens; Carcinoma, Hepatocellular; Carrier Proteins; Cholesterol; Diethylnitrosa | 1997 |
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; | 1997 |
Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinogens; Diet; Diethylnitrosamine; Drug Synergism; Hyperp | 1998 |
CD10/neutral endopeptidase inhibition augments pulmonary neuroendocrine cell hyperplasia in hamsters treated with diethylnitrosamine and hyperoxia.
Topics: Animals; Apoptosis; Calcitonin Gene-Related Peptide; Cricetinae; Diethylnitrosamine; Dipeptides; Fem | 1999 |
Effect of nodularin on the expression of glutathione S-transferase placental form and proliferating cell nuclear antigen in N-nitrosodiethylamine initiated hepatocarcinogenesis in the male Fischer 344 rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Hyperplasia; Liver; Liver Neoplas | 1999 |
Regulation of selection of liver nodules initiated with N-nitrosodiethylamine and promoted with nodularin injections in fischer 344 male rats by reciprocal expression of transforming growth factor-beta1 and its receptors.
Topics: Alkylating Agents; Animals; Blotting, Northern; Diethylnitrosamine; Gene Expression Regulation, Neop | 1999 |
Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; CDC2 Protein Kinase; Cell Cycle Proteins; Che | 2000 |
Hypothalamic GABA receptor functional regulation and liver cell proliferation.
Topics: Alkylating Agents; Animals; Cell Division; Chromatography, High Pressure Liquid; Diethylnitrosamine; | 2001 |
Effects of N-acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate.
Topics: Acetylcysteine; Animals; Diethylnitrosamine; Ditiocarb; Drug Synergism; Esophageal Neoplasms; Esopha | 2002 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Rapid production of hyperplastic liver nodules in rats treated with carcinogenic chemicals: a new approach for an in vivo short-term screening test for hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; Drug Eva | 1977 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo | 1979 |
Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; DNA Nucleotidyltransferases; Do | 1976 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver Neoplasms; Lung; Male; Mi | 1977 |
Comparability of histological alterations during carcinogenesis in animals and man, with special reference to hepatocarcinogenesis in fish.
Topics: Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fish Diseases; Humans; H | 1977 |
[Role of hyperplasia in hepatic carcinogenesis].
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Mice; N | 1978 |
Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice.
Topics: Animals; Benzidines; Benzopyrenes; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethylnitrosourea; | 1978 |
Sequential analysis of hepatic carcinogenesis: a comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal, and regenerating liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Membrane; Cell Transformation, Neoplastic; Cytoskeleton; Di | 1979 |
Epithelial alterations in fetal tracheal explants of Syrian golden hamsters exposed to diethylnitrosamine in utero.
Topics: Animals; Cell Differentiation; Cricetinae; Diethylnitrosamine; Epithelium; Female; Fetus; Gestationa | 1978 |
Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine.
Topics: Animals; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diethylnitrosamine; Esophageal | 1977 |
Induction and spontaneous regression of intense pulmonary neuroendocrine cell differentiation in a model of preneoplastic lung injury.
Topics: Animals; Cell Differentiation; Cell Transformation, Neoplastic; Cricetinae; Diethylnitrosamine; Dise | 1992 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Gluta | 1992 |
Promoting effects of potassium dibasic phosphate on early-stage renal carcinogenesis in unilaterally nephrectomized rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Body Weight; Bromodeoxyuridine; Carcinogens; Carcinoma, Renal Cell; Copper; Copper Sulfate; | 1992 |
Induction and spontaneous regression of pulmonary neuroendocrine cell hyperplasia in a hamster model.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Cell Division; Cricetinae; Diethylnitrosamine; | 1992 |
Promoting effects of cigarette smoke on the respiratory tract carcinogenesis of Syrian golden hamsters treated with diethylnitrosamine.
Topics: Animals; Cricetinae; Diethylnitrosamine; Hyperplasia; Lipid Peroxides; Lung; Male; Mesocricetus; Pap | 1992 |
Initiating activity of diethylnitrosamine in a rapid production model for pancreatic carcinomas in Syrian hamsters.
Topics: Animals; Carcinoma, Intraductal, Noninfiltrating; Cricetinae; Diethylnitrosamine; Female; Hyperplasi | 1991 |
The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors.
Topics: Adenoma; Alpha-Globulins; Animals; Body Weight; Carcinogens; Cell Division; Cyclohexenes; Diethylnit | 1991 |
Possible application to medium-term organ bioassays for renal carcinogenesis modifiers in rats treated with N-ethyl-N-hydroxyethylnitrosamine and unilateral nephrectomy.
Topics: Animals; Bromodeoxyuridine; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Drug Synergism; | 1991 |
Promoting effect of sodium chloride solution mist on the induction of papillomas on Syrian hamster tracheal mucosa following administration of diethylnitrosamine.
Topics: Adenocarcinoma; Administration, Inhalation; Animals; Cricetinae; Diethylnitrosamine; Hyperplasia; Lu | 1991 |
[Immunohistochemical observation on the proliferative activity of rat liver in early hepatocarcinogenesis].
Topics: Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Diethylnitrosamine; Female; Hyperplasia; Immunoh | 1991 |
Expression and induction of cytochrome P450 isozymes in hyperplastic nodules of rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Blotting, Western; Carcinogens; Cytochrome P-450 | 1991 |
Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alkylation; Animals; Cytochrome P-450 Enzyme System; Diethylnit | 1991 |
Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carbon Tetrachloride; Cell Division; Diethylnitrosa | 1990 |
Enhancing effect of oxymetholone, an anabolic steroid, on development of liver cell foci in rats initiated with N-diethylnitrosamine.
Topics: Animals; Atrophy; Carcinogens; Diethylnitrosamine; Hyperplasia; Leydig Cells; Liver Neoplasms, Exper | 1990 |
The androgen receptor and liver tumor development in mice.
Topics: Androgen-Insensitivity Syndrome; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Hyperplasia; | 1990 |
Immunohistochemical demonstration of Clara cell antigen in lung tumors of bronchiolar origin induced by N-nitrosodiethylamine in Syrian golden hamsters.
Topics: Animals; Antigens; Bronchi; Cricetinae; Diethylnitrosamine; Epitopes; Female; Hyperplasia; Immunohis | 1989 |
Activation of a ribosomal S6 protein kinase in rapidly emerging diethylnitrosamine-induced gamma-glutamyltranspeptidase-positive hyperplastic liver lesions of the rat.
Topics: Animals; Diethylnitrosamine; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; gamma-Glutamylt | 1989 |
Diethylnitrosamine-induced pulmonary endocrine cell hyperplasia and its association with adenomatosis and adenocarcinoma in rabbits.
Topics: Adenocarcinoma; Adenoma; Animals; Diethylnitrosamine; Endocrine Glands; Hyperplasia; Lung; Lung Neop | 1989 |
Fatty acid composition of phospholipids in mitochondria and microsomes during diethylnitrosamine carcinogenesis in rat liver.
Topics: Animals; Cardiolipins; Diethylnitrosamine; Fatty Acids; Hyperplasia; Liver Neoplasms; Liver Neoplasm | 1989 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
[Sensitivity of rat hepatocytes to phenobarbital after a single dose of N-nitrosodiethylamine in the embryonal and postnatal period or after partial hepatectomy].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Hyper | 1987 |
Liver cell proliferation induced by the mitogen ethylene dibromide, unlike compensatory cell proliferation, does not achieve initiation of rat liver carcinogenesis by diethylnitrosamine.
Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Ethylene Dibromide; gamma-Glutamyl | 1987 |
Effect of vitamin E on the induction and evolution of enzyme-altered foci in the liver of rats treated with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Transferase; Hematoxylin; Hyperp | 1987 |
4-Nitroquinoline 1-oxide-induced pulmonary endocrine cell hyperplasia in Syrian golden hamster.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cricetinae; Diethylnitrosamine; Hyperplasia; Lung; Lung Neoplasms | 1986 |
Resistance to oxidative stress by hyperplastic and neoplastic rat liver tissue monitored in terms of production of unpolar and medium polar carbonyls.
Topics: Aldehydes; Animals; Arachidonic Acid; Arachidonic Acids; Cell Transformation, Neoplastic; Chromatogr | 1986 |
An animal model for neuroendocrine lung cancer.
Topics: Animals; Cricetinae; Diethylnitrosamine; Disease Models, Animal; Histocytochemistry; Hyperplasia; Lu | 1988 |
Proliferative response of putative preneoplastic hepatocytes to triiodothyronine, aminoacids, glucagon and heparine.
Topics: Amino Acids; Animals; Cell Division; Diethylnitrosamine; Glucagon; Heparin; Hyperplasia; Liver Neopl | 1988 |
Oral leukoplakia and costochondral hyperplasia induced by diethylnitrosamine in hamsters exposed to cigarette smoke with or without dietary vitamin C.
Topics: Animals; Ascorbic Acid; Cartilage; Cartilage Diseases; Cricetinae; Diethylnitrosamine; Hyperplasia; | 1987 |
Time course of dolichol and dolichyl phosphate during chemical carcinogenesis in rat liver.
Topics: Acyl Coenzyme A; Animals; Diethylnitrosamine; Diterpenes; Dolichol Phosphates; Dolichols; Hepatectom | 1987 |
[Early morphofunctional changes in the liver after administration of nitrosodiethylamine].
Topics: Animals; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Male; Precancerous Conditions; Rat | 1986 |
Immunocytochemical localization of the surfactant apoprotein and Clara cell antigen in chemically induced and naturally occurring pulmonary neoplasms of mice.
Topics: Adenoma; Animals; Antigens; Apoproteins; Carcinoma; Diethylnitrosamine; Female; Hyperplasia; Immunoe | 1985 |
Dose-related effect of trisodium nitrilotriacetate monohydrate on renal tumorigenesis initiated with N-ethyl-N-hydroxyethylnitrosamine in rats.
Topics: Acetates; Animals; Carcinogens; Carcinoma, Renal Cell; Diethylnitrosamine; Dose-Response Relationshi | 1985 |