diethylnitrosamine has been researched along with Hepatocellular Carcinoma in 659 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the effect of combined therapy of diacerein and gold nanoparticles (AuNP) on diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in a rat model." | 8.31 | Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study. ( Baokbah, TAS, 2023) |
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 8.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "This study was designed to evaluate the potential protective impact of estrogen and estrogen receptor against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 8.31 | Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis. ( Abdel-Hamid, MS; Abdelhady, R; El-Sayed, EM; Elsadek, BEM; Hassan, MH; Mansour, AM; Salama, SA, 2023) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 8.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| " The present study investigates the anticancer activity of ligand-L and its mode of action in rat model of diethylnitrosamine (DEN) induced hepatocellular carcinoma." | 7.96 | Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma. ( Khan, S; Naseem, I; Zafar, A, 2020) |
| "This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment." | 7.96 | Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020) |
| " Nimbolide is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties; however, its anticancer effects and molecular mechanism in hepatocellular carcinoma (HCC) remains obscure." | 7.96 | Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis. ( Ram, AK; Srinivas, BH; Vairappan, B, 2020) |
| " In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanoparticles (GaNPs) combined with low level of gamma radiation (IR), on the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 7.91 | Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats. ( El-Sonbaty, SM; Mansour, SZ; Moawed, FS, 2019) |
| "Mito-TEMPO was effective in combating hepatocarcinogenesis." | 7.91 | Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. ( Bharati, S; Kumar, R; Shetty, S, 2019) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 7.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| " Diethylnitrosamine (DEN) is one of the recognized risk factors for hepatocarcinogenesis likely due to CYP2E1-mediated metabolic activation." | 7.88 | Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine. ( Chang, Z; Fang, Y; Gao, J; Gao, N; Jin, H; Qiao, HL; Wang, CE; Wang, GJ; Wang, J; Wang, Z; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 7.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| "Rationale of this study was framed to investigate the protective effect and anti-cancer property of nanoparticles based on chitosan isolated from squid, Sepioteuthis lessoniana, on hepatic cells in N-Nitrosodiethylamine-induced hepatocellular carcinoma in rats." | 7.85 | Chitosan nanoparticles from marine squid protect liver cells against N-diethylnitrosoamine-induced hepatocellular carcinoma. ( Shanmugam, A; Shanmugam, V; Subhapradha, N, 2017) |
| "This study aimed to evaluate the antitumor activity of platinum nanoparticles compared with cis-platin both in vitro and in vivo in the treatment of hepatocellular carcinoma induced in rats." | 7.85 | Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats. ( El-Sonbaty, S; Kandil, E; Mahmoud, M; Mansour, S; Medhat, A, 2017) |
| "The purpose of the present study was to evaluate the effects of cordycepin (CA) on N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinomas (HCC) and explore its potential mechanisms." | 7.85 | Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB pathway in mice. ( Chen, B; Li, D; Lian, S; Lin, X; Wei, H; Yang, T; Zeng, Y, 2017) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 7.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 7.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| " The aim of this study was to evaluate the anti-tumor effect of Celastrol against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats and furthermore, to explore the underlying mechanism." | 7.83 | Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. ( Chang, W; He, W; Li, PP; Lu, JT; Song, SS; Wei, W; Yuan, PF, 2016) |
| " To further confirm our hypothesis in vivo, we induced hepatocellular carcinoma (HCC) in rats by diethylnitrosamine (DEN)." | 7.81 | Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate. ( Ahmad, A; Farhan, M; Hadi, SM; Naseem, I; Rizvi, A, 2015) |
| " The present study was envisaged to investigate the possible synergistic effect of combined treatment of curcumin with piperine in suppression of diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats, owing to permeability enhancing effect of latter." | 7.81 | Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. ( Padwad, YS; Patial, V; Pratap, K; S, M; Sharma, S; Singh, D, 2015) |
| " The present experimental study was designed to outline the roles of these players and to investigate the tumor suppressive effects of curcumin with or without mesenchymal stem cells (MSCs) in hepatocellular carcinoma (HCC)." | 7.81 | Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy. ( Abdelmaqsoud, OM; Khaleel, EF; Tork, OM, 2015) |
| " The aim of this study was to investigate molecular mechanisms for the chemopreventive effects of folic acid and tributyrin alone or in combination on rat hepatocarcinogenesis." | 7.80 | Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. ( Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V, 2014) |
| "We investigated the possible therapeutic effect of irreversible proteasome inhibitor, carfilzomib against hepatocellular carcinoma induced chemically by chronic administration of diethylnitrosoamines (DENA)." | 7.80 | Possible role of selective, irreversible, proteasome inhibitor (carfilzomib) in the treatment of rat hepatocellular carcinoma. ( Al-Hosaini, K; Al-Rikabi, AC; Aljoufi, MA; Mansour, MA; Nagi, MN, 2014) |
| "The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model." | 7.80 | Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats. ( Geng, CZ; Liu, YP; Peng, L; Wang, SJ; Wang, X; Yang, HC; Zhao, JA, 2014) |
| "The possible molecular mechanisms of Nano-selenium (nano-se) in attenuating hepatocellular carcinoma (HCC) was investigated in this study." | 7.80 | Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats. ( Ahmed, HH; Hamza, AH; Khalil, WK, 2014) |
| " We recently find that the loss of toll-like receptor 2 (TLR2) activities promotes the diethylnitrosamine (DEN) induced hepatocellular carcinogenesis and tumor progression, which associates with an abundant accumulation of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress." | 7.79 | Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. ( Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ, 2013) |
| "Placental growth factor (PlGF) inhibition produced promising results in reducing tumor burden in a diethylnitrosamine (DEN)-induced mouse model for hepatocellular carcinoma (HCC)." | 7.79 | Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor. ( Blomme, B; Colle, I; Geerts, A; Heindryckx, F; Stassen, JM; Van Vlierberghe, H, 2013) |
| " DENA (diethylnitrosamine), a hepatocarcinogen, is commonly used in an experimental mouse model to induce liver cancer that closely mimics a subclass of human hepatocellular carcinoma (HCC)." | 7.76 | Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer. ( Chen, CC; Contreras, R; Dewaele, S; Fan, YD; Libert, C; Liu, XE; Van Huysse, J; Vanhooren, V; Wang, L; Zhuang, H, 2010) |
| " In our continuous search to discover bioactive compounds from natural products, we isolated (5R, 10R)-4R, 8R-dihydroxy-2S, 3R:15, 16-diepoxycleroda-13(16), 17, 12S:18,1S-dilactone (ECD), a diterpenoid from Tinospora cordifolia and studied its chemopreventive potential in diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) rats." | 7.75 | Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. ( Agastian, P; Baskar, AA; Dhanasekaran, M; Duraipandiyan, V; Ignacimuthu, S, 2009) |
| "Modified Diethylnitrosamine (DEN)-induced primary hepatocellular carcinoma rat model was established." | 7.75 | [The expression of B-cell translocation gene 2 in diethylnitrosamine-induced primary hepatocellular carcinoma rat model.]. ( Chen, C; Jin, F; Li, Q; Li, ZP; Luo, XZ; Shan, JL; Wang, D; Wang, G; Xu, W; Yang, ZX; Zhang, ZM, 2009) |
| " In the present study, we investigated the antiproliferative effect of gallic acid during diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in male wistar albino rats." | 7.74 | Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma. ( Anandakumar, P; Devaki, T; Jagan, S; Kamaraj, S; Ramakrishnan, G, 2008) |
| " We induced hepatocellular carcinomas (HCCs) in rats with N-nitrosodiethylamine (DEN) and a choline-deficient l-amino acid-defined (CDAA) diet." | 7.74 | Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats. ( Honoki, K; Mori, C; Nishikawa, T; Onishi, M; Sokuza, Y; Tsujiuchi, T; Uwataki, K, 2007) |
| "Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear." | 7.74 | Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008) |
| " Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) increases the drug efficacy on HCCs induced in rats by diethylnitrosamine (DENA)." | 7.73 | Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine. ( Bolondi, L; Busi, C; Chieco, P; Di Stefano, G; Fiume, L; Kratz, F; Lanza, M; Mattioli, A, 2005) |
| " However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and efficacy of hydrodynamic injection via the tail vein and hepatic artery in a diethylnitrosamine (DEN)-induced HCC model in rats." | 7.73 | High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine. ( Hatano, E; Ikai, I; Koizumi, N; Nitta, T; Shimahara, Y; Tada, M; Taura, K, 2006) |
| " In this study we report that gavage administration of 200 mg/kg or 600 mg/kg CCM effectively suppressed diethylnitrosamine (DEN)-induced liver inflammation and hyperplasia in rats, as evidenced by histopathological examination." | 7.70 | Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. ( Cheng, AL; Chuang, SE; Kuo, ML; Lin, JK, 2000) |
| "In rats with diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC), we studied in vivo gene transfer efficiency using intraportal injections of recombinant adenovirus carrying the lacZ reporter gene (AdCMVlacZ) and the therapeutic efficacy of adenovirus-mediated transfer of the thymidine kinase gene of the herpes simplex virus (HSV-tk) followed by ganciclovir (GCV) administration." | 7.69 | Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma. ( Bilbao, R; Bruña, O; Idoate, M; Prieto, J; Qian, C; Sangro, B; Vázquez, J, 1997) |
| "The effects of treatments with diethylnitrosamine (DENA) and hepatitis B virus (HBV) on macaque monkeys were investigated by virus serology and by light and electron microscopy." | 7.65 | Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus. ( Cabral, GA; Gyorkey, F; Gyorkey, P; Hollinger, FB; Melnick, JL; Mirkovic, R, 1977) |
| "Hepatocellular carcinoma is the second most cause of death among the various cancers worldwide." | 5.91 | Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats. ( Amudha, P; Jayalakshmi, M; Poojitha, BN; Vidya, R, 2023) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 5.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of hepatocellular carcinoma (HCC)." | 5.72 | Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet. ( Chun, HJ; Kwon, YH; Shim, YJ, 2022) |
| "ADI can inhibit a lot of CYP450 enzyme, so it may reduce the dosage of chemotherapeutic drugs to reach the required plasma concentration of chemotherapeutic drugs, which is of great significance for the combination of anti-tumor chemotherapeutic drugs and is worthy of further in-depth study and clinical attention." | 5.72 | Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats. ( He, Y; Huang, Y; Jin, Y; Li, Y; Liu, W; Lu, Y; Pan, J; Wang, Y; Zheng, L, 2022) |
| "Prunetin (PRU) is an O-methylated flavonoid that is present in various natural plants and a primary significant compound found in isoflavone." | 5.72 | Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats. ( Chen, H; Li, G; Qi, L; Tian, G, 2022) |
| "Boron has great potential to reduce the effects of oxidative stress, which may help it inhibit the progression of HCC." | 5.72 | Boron attenuated diethylnitrosamine induced hepatocellular carcinoma in C3H/HeN mice via alteration of oxidative stress and apoptotic pathway. ( Chen, J; Huang, H; Wang, J; Wei, Y; Wu, L; Yi, JK; Yin, X, 2022) |
| "Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality." | 5.62 | Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma. ( Balaraman, G; Krishnan, P; Mari, A; Salam, S; Sirajduddin, I; Subramaniam, N; Sundaram, J; Thiruvengadam, D, 2021) |
| " The study aimed to investigate the pharmacokinetic mechanism of herb-drug interactions between ADI and DOX in a rat model of HCC." | 5.62 | Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma. ( Cao, C; Chen, S; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zhang, S; Zhu, X, 2021) |
| "Alogliptin is an anti-diabetic that may have effective anticancer properties against many types of malignancies." | 5.62 | Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. ( Abd Elmaaboud, MA; Arab, HH; Kabel, AM, 2021) |
| "Liver cancer was induced in mice with hepatocyte-specific disruption of Myc and control mice by administration of diethylnitrosamine." | 5.62 | Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. ( Cai, J; Chen, L; Gao, Y; Gonzalez, FJ; Guo, X; Jiang, J; Krausz, KW; Liu, W; Luo, Y; Qu, A; Sun, L; Takahashi, S; Tang, W; Wang, Y; Xie, C; Yang, S; Yang, Y, 2021) |
| " However, the bioavailability of ABZ is very poor." | 5.62 | Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression. ( Amin, NA; Batiha, GE; El-Ahwany, E; El-Rous, MA; Elagamy, HI; Elewa, YHA; Elsergany, RN; Girgis, S; Gobba, NA; Hafez, AM; Kaddah, MMY; Kamal, I; Khodir, AE; Mahmoud, MH; Mourad, AAE; Nasr, M; Saad, AS; Saber, S; Shata, A, 2021) |
| "ET in the prevention of liver cancer is poorly understood." | 5.56 | Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine. ( Cao, L; Ding, S; Ji, B; Li, L; Qi, Z; Zhang, X, 2020) |
| " Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation." | 5.56 | Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 5.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| "Treatment of DEN-induced hepatocellular carcinoma Wistar rats with the extract caused significant (p < 0." | 5.56 | Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats. ( Adebayo, AH; Adelani, IB; Adesina, GO; Edokwe, CB; Metibemu, DS; Oseha, OE; Yakubu, OF, 2020) |
| "Sorafenib (SO) is a multi-kinase inhibitor that targets upstream signals in the MAPK pathway." | 5.51 | Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma. ( Ghanim, AMH; Saber, S; Younis, NS, 2019) |
| "Echinacoside (ECH) is a phenylethanoid glycoside extracted from a Chinese herbal medicine, Cistanches salsa." | 5.51 | Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells. ( Ni, J; Song, Y; Wang, G; Xia, W; Ye, Y; Zhuang, J, 2019) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 5.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "Hepatocellular carcinoma is the most frequent kind of primary liver cancer and occurs mostly in patients with chronic liver disease and cirrhosis." | 5.51 | Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway. ( Cui, G; Shang, X; Wang, N; Yang, G; Zhao, H; Zhao, L, 2019) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 5.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC)." | 5.48 | Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis. ( Inoue-Yamauchi, A; Itagaki, H; Oda, H, 2018) |
| "The global burden of hepatocellular carcinoma is increasing; actually, it is estimated as 750,000 new cases annually." | 5.46 | Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study. ( Aglan, HA; Ahmed, HH; El-Toumy, SA; Mahmoud, NS, 2017) |
| "Rats from all groups were assessed for liver cancer progression or inhibition by evaluating histological, biochemical, antioxidant enzyme status, cytokines and gene expression profiles." | 5.46 | Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats. ( Abuzenadah, A; Al-Qahtani, M; Barbour, E; Chaudhary, A; Kalamegam, G; Khan, F; Khan, TJ; Kumosani, T; Pushparaj, PN, 2017) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 5.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "Caudatin is a potential antitumor agent isolated from the traditional Chinese medicine "baishouwu", which was the root tuber of Cynanchum auriculatum Royle ex Wight." | 5.42 | Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats. ( Ding, Y; Peng, Y, 2015) |
| "At present, the treatment of hepatocellular carcinoma (HCC) is an international problem." | 5.42 | Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Chen, Q; Li, Y; Liu, W; Tang, H; Yang, X; Zhao, X, 2015) |
| "The treatment with astemizole prevented diethylnitrosamine (DEN)-induced rat HCC development in vivo (followed by studying γ-glutamyl transpeptidase (GGT) activity)." | 5.42 | Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1 channels as potential early-stage markers of HCC. ( Acuña-Macías, I; Camacho, J; Caro-Sánchez, CH; Chiliquinga, AJ; de Guadalupe Chávez-López, M; Díaz-Chávez, J; Gariglio, P; Hernández-Gallegos, E; Herrera, LA; Pérez-Carreón, JI; Zuñiga-García, V, 2015) |
| "Fgl1 expression is decreased in hepatocellular carcinoma (HCC) and its loss correlates with a poorly differentiated phenotype." | 5.42 | Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. ( Bronson, RT; Cohen, DE; Demchev, V; Desai, A; Hornick, JL; Nayeb-Hashemi, H; Ukomadu, C, 2015) |
| "Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date." | 5.42 | Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients. ( Hu, C; Huang, X; Lin, X; Niu, J; Tan, Y; Wang, H; Wang, X; Yin, P; Zeng, J; Zhou, L, 2015) |
| "Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 5.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
| "Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1α hepatic expression." | 5.40 | Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Hamed, O; Kazem, A; Nasr, M; Selima, E, 2014) |
| "Interestingly, HFD, which induced hyperlipidemia and hepatic steatosis, attenuated DEN-related malnutrition and fibrosis progression in HFD + DEN group during 10-14 weeks." | 5.40 | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. ( Ding, WJ; Duan, XY; Fan, JG; Pan, Q; Qiao, L; Yan, SY, 2014) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 5.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| "The findings suggest that RGP prevents hepatocellular carcinoma by suppressing the marked increase in the levels of serum marker enzymes, and suppresses the free radical by scavenging hydroxyl radicals." | 5.39 | Anticancer potential of rhamnocitrin 4'-β-D-galactopyranoside against N-diethylnitrosamine-induced hepatocellular carcinoma in rats. ( Ahmad, K; Ahmad, P; Al-Harbi, NO; Alam, MJ; Imam, F; Iqbal, M; Khusroo, MJ; Rahman, RU; Saleem, S; Shaharyar, MA, 2013) |
| "Hepatocellular carcinoma is one of the most common cancers and lethal diseases in the world." | 5.38 | Myrtenal, a natural monoterpene, down-regulates TNF-α expression and suppresses carcinogen-induced hepatocellular carcinoma in rats. ( Babu, LH; Balasubramanian, MP; Perumal, S, 2012) |
| " Simultaneously, hepatocarcinoma were induced in groups II-V by diethylnitrosamine (DEN) solution (100 mg/L) at the dosage of 10 mg/kg body weight every day as drinking water for 16 weeks, then sterilized water for a further two weeks." | 5.35 | Effect of selenium-enriched malt on hypoglycemia and regulatory hormones in diethylnitrosamine-induced hepatocarcinoma SD rats. ( Liu, JG; Liu, YJ; Wang, XL; Zhao, HJ, 2009) |
| "Ursolic acid is a natural triterpenoid widely found in food, medicinal herbs, apple peel and other products it has been extensively studied for its anticancer and antioxidant properties." | 5.35 | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2009) |
| "Incidences of lung metastasis in the 40 ppm group steadily increased up to 67% by week 36 while that in the 80 ppm increased sharply up to 86% by week 24." | 5.33 | Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. ( Cho, YM; Futakuchi, M; Imai, N; Ogawa, K; Shirai, T; Takeshita, F; Tamano, S; Yoshino, H, 2005) |
| "The question whether hepatocellular carcinoma (HCC) arises from dedifferentiation of mature hepatocytes or from proliferation of liver stem cells is still debated." | 5.31 | Demonstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats. ( Bralet, MP; Ferry, N; Pichard, V, 2002) |
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 5.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| " To this end, chemical carcinogenesis protocols based on the injection of genotoxic compounds such as diethylnitrosamine (DEN) are widely used to model liver tumorigenesis in rodents." | 5.12 | Diethylnitrosamine-induced liver tumorigenesis in mice. ( Hasselblatt, P; Schulien, I, 2021) |
| " Six rats each were given tap water containing diethylnitrosamine (DEN) at 100 ppm for 8 or 14 weeks; Adenoma group and Hepatocellular carcinoma (HCC) group, respectively." | 4.31 | Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model. ( Jogo, A; Kageyama, K; Kakehashi, A; Miki, Y; Murai, K; Nota, T; Ogawa, S; Sohgawa, E; Yamamoto, A; Yonezawa, H, 2023) |
| "The purpose of this study was to investigate the effect of combined therapy of diacerein and gold nanoparticles (AuNP) on diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in a rat model." | 4.31 | Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study. ( Baokbah, TAS, 2023) |
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 4.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "This study was designed to evaluate the potential protective impact of estrogen and estrogen receptor against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 4.31 | Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis. ( Abdel-Hamid, MS; Abdelhady, R; El-Sayed, EM; Elsadek, BEM; Hassan, MH; Mansour, AM; Salama, SA, 2023) |
| " O-GlcNAc transferase-KO mice exacerbated diethylnitrosamine-induced HCC development with increased inflammation, fibrosis, and YAP signaling." | 4.31 | The essential role of O-GlcNAcylation in hepatic differentiation. ( Apte, U; Hanover, JA; Kotulkar, M; Paine-Cabrera, D; Robarts, DR; Slawson, C; Venneman, KK; Zachara, NE, 2023) |
| " Further we emphasize to study the role of CPT against hepatocellular carcinoma (HCC) induced by N-diethylnitrosamine (DEN) in male swiss albino mice in vivo." | 4.12 | Potential anticancer effects of cyclo(-Pro-Tyr) against N-diethyl nitrosamine induced hepatocellular carcinoma in mouse through PI3K/AKT signaling. ( Arumugam, MK; Karanam, G, 2022) |
| "25% salt in drinking water improved body weight reduction associated with sodium and water retention in hepatocellular carcinoma rats, which was suppressed by treatment with spironolactone, a mineralocorticoid receptor antagonist." | 4.12 | Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats. ( Kidoguchi, S; Kitada, K; Kittikulsuth, W; Kobara, H; Masaki, T; Nakajima, K; Nakano, D; Nishiyama, A; Ohsaki, H; Takahashi, K; Titze, J; Yokoo, T, 2022) |
| "Our results show that the expression of mRNA of IQGAP1, TRAIL decoy receptors, NF-κB, and IL-8 genes was elevated in hepatocellular carcinoma, as compared to normal liver tissue, while their expression was further up-regulated by increasing the dose of diethylnitrosamine." | 4.12 | New Approach about the Signaling Crosstalk between IQGAPs/ NF- κB/IL-8 and PDCD5/p53/TRAIL Pathways that Modulate Malignant Transformation in Hepatocellular Carcinoma. ( Abdelhafez, MA; Darwish, AM; Mahrous, KF; Zoheir, KMA, 2022) |
| "Swiss Albino (BALB/c) mice of around 10-12 weeks old were exposed to a known hepatocarcinogen-diethylnitrosamine at a dose of 20 mg/kg body weight at weekly intervals for a period of 4, 8, 12, & 16 weeks." | 4.12 | Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma. ( Kma, L; Priya, S, 2022) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 4.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| "Hepatocellular carcinoma was induced in 40 rats with diethylnitrosamine." | 4.12 | Therapeutic Role of Bone Marrow-Derived Mesenchymal Stem Cells in Controlling Prognosis of Hepatocellular Carcinoma in a Murine Model. ( Abd El Fattah El Sayed, H; Atta, S; Elzayat, E; Hussein, T; Kamel, M; Mahmood, D; Mansour, W; Saber, S, 2022) |
| " Take advantage of the combinatory treatment with a single dose of diethylnitrosamine (DEN) and chronic feeding with high-fat diet (HFD), we demonstrated that hepatic depdc5 deletion did not aggravate DEN&HFD induced liver tumorigenesis, probably due to its protective effects on diet-induced liver steatosis." | 4.02 | Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice. ( Huang, R; Li, Z; Ma, H; Ma, J; Wang, J; Wang, Q; Xiong, X; Xu, L; Yang, C, 2021) |
| "Recently, our group showed that Romidepsin, a histone deacetylase inhibitor (HDACi), suppressed diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in mice." | 4.02 | Romidepsin hepatocellular carcinoma suppression in mice is associated with deregulated gene expression of bone morphogenetic protein and Notch signaling pathway components. ( Afaloniati, H; Angelopoulou, K; Gargavanis, A; Giakoustidis, A; Giakoustidis, D; Poutahidis, T, 2021) |
| " Here, hyperpolyploidization of hepatocytes around the centrilobular (CL) region is demonstrated to be closely linked with the development of HCC cells after diethylnitrosamine treatment." | 4.02 | Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver. ( Chao, HW; Chen, H; Chen, HW; Doi, M; Fustin, JM; Hou, HS; Huang, YS; King, PC; Lai, HH; Lee, YL; Lin, H; Lin, SH; Young, PY, 2021) |
| " In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis." | 4.02 | Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks. ( Campbell, MJ; Clinton, SK; Coss, CC; Getaneh, S; Helms, TH; Kulp, SK; LeMoine, DM; Lucas, F; Mullins, RD; Phelps, MA; Schmidt, N; Thomas-Ahner, JM; Xie, Z, 2021) |
| " nigra extract (MNE) on diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC)." | 4.02 | Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma. ( Ghorbani, A; Hasanpour, M; Hooshmand, S; Iranshahi, M; Mahdinezhad, MR; Mirzavi, F; Soukhtanloo, M; Taraz Jamshidi, S, 2021) |
| " Here, we investigated the effects of maternal diets differing in protein source on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in adult rat offspring." | 3.96 | Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring. ( Choi, J; Kwon, YH; Won, SB, 2020) |
| " The present study investigates the anticancer activity of ligand-L and its mode of action in rat model of diethylnitrosamine (DEN) induced hepatocellular carcinoma." | 3.96 | Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma. ( Khan, S; Naseem, I; Zafar, A, 2020) |
| "This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment." | 3.96 | Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020) |
| " Nimbolide is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties; however, its anticancer effects and molecular mechanism in hepatocellular carcinoma (HCC) remains obscure." | 3.96 | Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis. ( Ram, AK; Srinivas, BH; Vairappan, B, 2020) |
| " In the second set of experiments, hypertrophy of the adipocytes was suppressed, and the concentration of adiponectin and leptin in the adipose tissue decreased by MCT." | 3.91 | Effects of Medium-chain Triglycerides Administration in Chemically-induced Carcinogenesis in Mice. ( Akazawa, Y; Fujii, H; Fukushima, H; Hagio, K; Ichikawa, D; Kono, H; Maruyama, S; Nakata, Y; Wakana, H, 2019) |
| " We observed that FUN14 domain-containing 1 (FUNDC1), a previously characterized mitophagy receptor, accumulates in most human hepatocellular carcinomas (HCCs), and we thus explored the role of FUNDC1-mediated mitophagy in HCC initiation and progression in a mouse model in which HCC is induced by the chemical carcinogen, diethylnitrosamine (DEN)." | 3.91 | FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice. ( Chen, Q; Du, L; Fan, Y; Huang, X; Jin, H; Li, W; Li, Y; Liu, L; Siraj, S; Wang, J; Wang, X; Yang, X, 2019) |
| " In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanoparticles (GaNPs) combined with low level of gamma radiation (IR), on the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 3.91 | Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats. ( El-Sonbaty, SM; Mansour, SZ; Moawed, FS, 2019) |
| "Mito-TEMPO was effective in combating hepatocarcinogenesis." | 3.91 | Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. ( Bharati, S; Kumar, R; Shetty, S, 2019) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 3.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| " Diethylnitrosamine (DEN) is one of the recognized risk factors for hepatocarcinogenesis likely due to CYP2E1-mediated metabolic activation." | 3.88 | Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine. ( Chang, Z; Fang, Y; Gao, J; Gao, N; Jin, H; Qiao, HL; Wang, CE; Wang, GJ; Wang, J; Wang, Z; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| " We studied mice with bile-duct ligation, orthotopic cholangiocarcinomas, cholestasis-induced cholangiocarcinoma, diethylnitrosamine-induced liver tumors, and xenograft tumors." | 3.88 | Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. ( Annamalai, A; Fan, W; Li, TWH; Liu, T; Liu, Z; Lu, SC; Maldonado, SS; Mato, JM; Noureddin, M; Seki, E; Shen, H; Steggerda, J; Tu, J; Wang, J; Xiong, T; Yang, H; Yang, J, 2018) |
| "Hepatocellular carcinoma (HCC) was induced in male Wistar rats by the administration of diethylnitrosamine (DEN) during 16 weeks." | 3.88 | Resistive Part of Impedance as a Possible Indicator of Hepatocellular Carcinoma. ( Camacho, J; Chávez-López, MG; Elías-Viñas, D; Salazar-Anguiano, J; Zúñiga-García, V, 2018) |
| "encapsulated GA-NC (gallic acid nanocomposite) in normal and hepatocellular carcinoma (HCC)-induced rats." | 3.88 | Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation ( Abd-Rabou, AA; Ahmed, HH; Galal, AF; Mehaya, FM; Shalby, AB, 2018) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 3.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| "Rationale of this study was framed to investigate the protective effect and anti-cancer property of nanoparticles based on chitosan isolated from squid, Sepioteuthis lessoniana, on hepatic cells in N-Nitrosodiethylamine-induced hepatocellular carcinoma in rats." | 3.85 | Chitosan nanoparticles from marine squid protect liver cells against N-diethylnitrosoamine-induced hepatocellular carcinoma. ( Shanmugam, A; Shanmugam, V; Subhapradha, N, 2017) |
| " Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which are the major molecules to be responsible for transducing insulin/IGF signaling in the liver, in the development of HCC by inducing chemical carcinogenesis using diethylnitrosamine (DEN) in mice." | 3.85 | Role of insulin receptor substrates in the progression of hepatocellular carcinoma. ( Aihara, M; Hayashi, T; Iwamoto, M; Kadowaki, T; Kubota, N; Kubota, T; Nishihara, H; Obata, A; Sakurai, Y; Takamoto, I, 2017) |
| "This study aimed to evaluate the antitumor activity of platinum nanoparticles compared with cis-platin both in vitro and in vivo in the treatment of hepatocellular carcinoma induced in rats." | 3.85 | Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats. ( El-Sonbaty, S; Kandil, E; Mahmoud, M; Mansour, S; Medhat, A, 2017) |
| " Hepatocellular Carcinoma (HCC) was induced in the liver of male Sprague Dawley (SD) rats by treating with diethylnitrosamine (DEN)." | 3.85 | In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model. ( Antony Joseph, SR; Krishnan, GS; Rajagopal, V; Savarimuthu, I; Sebastian, D; Selvaraj, KRN; Thobias, AF, 2017) |
| "The purpose of the present study was to evaluate the effects of cordycepin (CA) on N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinomas (HCC) and explore its potential mechanisms." | 3.85 | Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB pathway in mice. ( Chen, B; Li, D; Lian, S; Lin, X; Wei, H; Yang, T; Zeng, Y, 2017) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 3.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 3.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| " Using the diethylnitrosamine-induced hepatocarcinogenesis model, 2-Formyl-8-hydroxy-quinolinium chloride showed strong antiangiogenic activity." | 3.83 | Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride. ( Bian, ZX; Chan, KW; Chan, RY; Cheng, CH; Cheng, GY; Chui, CH; Gambari, R; Hau, DK; Kok, SH; Lam, KH; Lau, FY; Lee, KK; Tang, JC; Tong, SW; Wong, RS; Wong, WY, 2016) |
| " The aim of this study was to evaluate the anti-tumor effect of Celastrol against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats and furthermore, to explore the underlying mechanism." | 3.83 | Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. ( Chang, W; He, W; Li, PP; Lu, JT; Song, SS; Wei, W; Yuan, PF, 2016) |
| "The purpose of this study was to reduce the time to tumor onset in a diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) swine model via partial liver embolization (PLE) and to characterize the model for use in translational research." | 3.83 | Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs. ( Amin, HM; Avritscher, R; Cressman, E; Eskandari, G; Kaseb, AO; Konnath George, S; Mitchell, J; Morris, JS; Rashid, A; Tinkey, PT; Uthamanthil, R; Van Pelt, C; Xiao, L, 2016) |
| " The target of the current study was to examine the immunomodulatory effect of DEC, Setaria equina ES or a combination of them on rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine (DEN)." | 3.81 | Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. ( Abdel-Latif, M; El-Fayoumi, H; El-Mallah, AM; El-Shahawi, G; Sakran, T, 2015) |
| "In this study, we explored whether treatment with FGF-21 could prevent diethylnitrosamine (DEN) induced hepatocarcinogenesis in mice." | 3.81 | Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice. ( Li, D; Liu, M; Liu, Z; Rasoul, LM; Ren, G; Wang, W; Wu, Q; Xu, P; Ye, X; Yuan, Q; Zhang, Y, 2015) |
| " To further confirm our hypothesis in vivo, we induced hepatocellular carcinoma (HCC) in rats by diethylnitrosamine (DEN)." | 3.81 | Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate. ( Ahmad, A; Farhan, M; Hadi, SM; Naseem, I; Rizvi, A, 2015) |
| " Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals." | 3.81 | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging. ( Fujisawa, K; Furutani-Seiki, M; Matsumoto, T; Nishina, H; Sakaida, I; Takami, T; Terai, S; Yamamoto, N, 2015) |
| " The present study was envisaged to investigate the possible synergistic effect of combined treatment of curcumin with piperine in suppression of diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats, owing to permeability enhancing effect of latter." | 3.81 | Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. ( Padwad, YS; Patial, V; Pratap, K; S, M; Sharma, S; Singh, D, 2015) |
| " The present experimental study was designed to outline the roles of these players and to investigate the tumor suppressive effects of curcumin with or without mesenchymal stem cells (MSCs) in hepatocellular carcinoma (HCC)." | 3.81 | Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy. ( Abdelmaqsoud, OM; Khaleel, EF; Tork, OM, 2015) |
| " The aim of this study was to investigate molecular mechanisms for the chemopreventive effects of folic acid and tributyrin alone or in combination on rat hepatocarcinogenesis." | 3.80 | Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. ( Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V, 2014) |
| " In this study, we characterized cell signaling events evoked by decorin deficiency in two experimental models of hepatocarcinogenesis using thioacetamide or diethyl nitrosamine as carcinogens." | 3.80 | Decorin deficiency promotes hepatic carcinogenesis. ( Baghy, K; Fullár, A; Horváth, Z; Iozzo, RV; Kiss, K; Kovalszky, I; Schaff, Z, 2014) |
| "We investigated the possible therapeutic effect of irreversible proteasome inhibitor, carfilzomib against hepatocellular carcinoma induced chemically by chronic administration of diethylnitrosoamines (DENA)." | 3.80 | Possible role of selective, irreversible, proteasome inhibitor (carfilzomib) in the treatment of rat hepatocellular carcinoma. ( Al-Hosaini, K; Al-Rikabi, AC; Aljoufi, MA; Mansour, MA; Nagi, MN, 2014) |
| "The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model." | 3.80 | Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats. ( Geng, CZ; Liu, YP; Peng, L; Wang, SJ; Wang, X; Yang, HC; Zhao, JA, 2014) |
| "The possible molecular mechanisms of Nano-selenium (nano-se) in attenuating hepatocellular carcinoma (HCC) was investigated in this study." | 3.80 | Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats. ( Ahmed, HH; Hamza, AH; Khalil, WK, 2014) |
| " The chemically-induced mouse model of diethylnitrosamine (DEN) provides useful insight into liver carcinogenesis, namely HCC." | 3.80 | The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions. ( Colaço, A; Da Costa, RM; Lopes, C; Oliveira, PA; Paula-Santos, N; Rocha, AF, 2014) |
| " In this study, we found that diethylnitrosamine initiation with CCl4 and ethanol promotion could induce a short-term, two-stage liver carcinogenesis model in male BALB/c mice, the process of hepatocarcinogenesis including liver damage, liver necrosis/cell death, liver inflammation, liver proliferation, liver hyperplasia, liver steatosis, and liver cirrhosis and hepatocellular nodules, which mimicked the usual sequence of events observed in human HCC." | 3.79 | Two-stage model of chemically induced hepatocellular carcinoma in mouse. ( Huang, SX; Kuang, ZP; Li, YD; Luo, M; Luo, XL; Wu, JN; Xie, YA; Yang, F, 2013) |
| " We recently find that the loss of toll-like receptor 2 (TLR2) activities promotes the diethylnitrosamine (DEN) induced hepatocellular carcinogenesis and tumor progression, which associates with an abundant accumulation of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress." | 3.79 | Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. ( Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ, 2013) |
| " To explore the role of CHOP in hepatocarcinogenesis, we induced hepatocellular carcinoma (HCC) in wild type (wt) and CHOP knockout (KO) mice using the carcinogen N-diethylnitrosamine (DEN)." | 3.79 | CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. ( Chung, RT; Mueller, T; Nahmias, A; Scaiewicz, V; Shibolet, O; Tirosh, B, 2013) |
| "Placental growth factor (PlGF) inhibition produced promising results in reducing tumor burden in a diethylnitrosamine (DEN)-induced mouse model for hepatocellular carcinoma (HCC)." | 3.79 | Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor. ( Blomme, B; Colle, I; Geerts, A; Heindryckx, F; Stassen, JM; Van Vlierberghe, H, 2013) |
| " The aim of this study was to investigate the inhibitory effect of a glycoprotein (38 kDa) isolated from Styrax japonica Siebold et al Zuccarini (SJSZ) on metastasis of hepatocellular carcinoma (HCC) in diethylnitrosamine (DEN)-treated imprinting control region (ICR) mice." | 3.78 | Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice. ( Lee, J; Lim, KT, 2012) |
| "Human hepatocellular carcinoma cells in culture, as well as nude mice transplanted with hepatocellular carcinoma cells and rats given with N-diethylnitrosamine were treated with acyclic retinoid." | 3.77 | Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells. ( Fukaya, Y; Ishibashi, N; Kojima, S; Moriwaki, H; Okuno, M; Sano, T; Tatsukawa, H; Watanabe, M, 2011) |
| "Diethylnitrosamine (DEN) is a hepatic procarcinogen which is frequently used as an inducer of hepatocellular carcinoma (HCC) in mice." | 3.77 | Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice. ( Aleksic, K; Auer, M; Fischer, M; Geigl, JB; Lackner, C; Otte, M; Schwarz, M; Speicher, MR; Trajanoski, Z; Ulz, P, 2011) |
| " Furthermore, Shp2 ablation dramatically enhanced diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) development, which was abolished by concurrent deletion of Shp2 and Stat3 in hepatocytes." | 3.77 | Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. ( Bailly-Maitre, B; Bard-Chapeau, EA; Ding, J; Fang, DD; Feng, GS; Han, T; Li, S; Poli, V; Princen, F; Varki, NM; Wang, H; Zhang, SS; Zhu, HH, 2011) |
| "Sorafenib is an FDA-approved agent for treatment of human hepatocellular carcinoma (HCC), but tumor shrinkage is minor." | 3.77 | c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition. ( Carr, BI; Cavallini, A; D'Alessandro, R; Refolo, MG; Wang, M; Wang, Z, 2011) |
| ") against diethylnitrosamine (DEN) induced hepatocellular carcinoma in rats." | 3.77 | The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats. ( Abdel-Hamid, AH; Ammar, NM; Farrag, AR; Ghanem, KZ; Kholeif, TE; Metwally, NS, 2011) |
| "From our findings we conclude that bacoside A is effective to prevent DEN-induced hepatocellular carcinoma by quenching lipid peroxidation and enhancing antioxidant status through free radical scavenging mechanism and having potential of protecting endogenous enzymatic and non-enzymatic antioxidant activity." | 3.76 | Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. ( Geetha, A; Janani, P; Parthasarathy, C; Ravisankar, B; Sivakumari, K, 2010) |
| " DENA (diethylnitrosamine), a hepatocarcinogen, is commonly used in an experimental mouse model to induce liver cancer that closely mimics a subclass of human hepatocellular carcinoma (HCC)." | 3.76 | Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer. ( Chen, CC; Contreras, R; Dewaele, S; Fan, YD; Libert, C; Liu, XE; Van Huysse, J; Vanhooren, V; Wang, L; Zhuang, H, 2010) |
| " In our continuous search to discover bioactive compounds from natural products, we isolated (5R, 10R)-4R, 8R-dihydroxy-2S, 3R:15, 16-diepoxycleroda-13(16), 17, 12S:18,1S-dilactone (ECD), a diterpenoid from Tinospora cordifolia and studied its chemopreventive potential in diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) rats." | 3.75 | Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. ( Agastian, P; Baskar, AA; Dhanasekaran, M; Duraipandiyan, V; Ignacimuthu, S, 2009) |
| "Gadolinium-enhanced multi-phase dynamic imaging has improved the accuracy of the diagnosis of hypervascular hepatocellular carcinoma (HCC), but using gadolinium-enhanced dynamic imaging alone is problematic in evaluating hypovascular HCC." | 3.75 | Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents. ( Bian, J; Guo, DM; Liu, SF; Qiu, TS; Wang, CZ, 2009) |
| "Modified Diethylnitrosamine (DEN)-induced primary hepatocellular carcinoma rat model was established." | 3.75 | [The expression of B-cell translocation gene 2 in diethylnitrosamine-induced primary hepatocellular carcinoma rat model.]. ( Chen, C; Jin, F; Li, Q; Li, ZP; Luo, XZ; Shan, JL; Wang, D; Wang, G; Xu, W; Yang, ZX; Zhang, ZM, 2009) |
| "Experiments were designed to examine the effect of N-Nitrosodiethylamine (NDEA) as cancer-inducer compound and to confirm the preventive effect of the flavonoid quercetin on hepatocellular carcinoma in rats." | 3.75 | Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences. ( Elmaghraby, TK; Hafez, EE; Ibrahim, SS; Seufi, AM, 2009) |
| " In the present study, we investigated the antiproliferative effect of gallic acid during diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in male wistar albino rats." | 3.74 | Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma. ( Anandakumar, P; Devaki, T; Jagan, S; Kamaraj, S; Ramakrishnan, G, 2008) |
| " We induced hepatocellular carcinomas (HCCs) in rats with N-nitrosodiethylamine (DEN) and a choline-deficient l-amino acid-defined (CDAA) diet." | 3.74 | Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats. ( Honoki, K; Mori, C; Nishikawa, T; Onishi, M; Sokuza, Y; Tsujiuchi, T; Uwataki, K, 2007) |
| "Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear." | 3.74 | Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008) |
| " Growth of hepatocellular carcinoma (HCC), developed by a single injection of diethylnitrosamine (DEN), was the same in both the TIS21(+/+) and TIS21(-/-) mice until 6 months, whereas it was significantly higher in the TIS21(-/-) mice at 9 months." | 3.74 | TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop. ( Kang, SY; Kim, BW; Kim, HC; Kim, JY; Lim, IK; Oh, SP; Park, TJ; Song, KY; Wang, HJ, 2008) |
| "Taken together, these findings identify a mechanism of ABT-100 function and show the efficacy of ABT-100 as a chemopreventive agent of hepatocellular carcinoma." | 3.73 | Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent. ( Carloni, V; Pantaleo, P; Vizzutti, F, 2005) |
| " Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) increases the drug efficacy on HCCs induced in rats by diethylnitrosamine (DENA)." | 3.73 | Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine. ( Bolondi, L; Busi, C; Chieco, P; Di Stefano, G; Fiume, L; Kratz, F; Lanza, M; Mattioli, A, 2005) |
| " However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and efficacy of hydrodynamic injection via the tail vein and hepatic artery in a diethylnitrosamine (DEN)-induced HCC model in rats." | 3.73 | High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine. ( Hatano, E; Ikai, I; Koizumi, N; Nitta, T; Shimahara, Y; Tada, M; Taura, K, 2006) |
| "Hepatocellular carcinoma (HCC) was induced by diethylnitrosamine in 70 treated rats with 20 normal rats used as controls." | 3.73 | In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model. ( Li, X; Xie, JX; Xu, H; Yang, ZH, 2006) |
| "To elucidate involvement of the transforming growth factor-beta (TGF-beta) signaling pathway in endogenous and exogenous liver carcinogenesis, we investigated mutations of TGF-beta receptor type II (TGF-betaRII), Smad2 and Smad4 genes, and expression of TGF-betaRII in hepatocellular carcinomas (HCCs) induced by a choline-deficient L-amino acid-defined (CDAA) diet and by N-nitrosodiethylamine (DEN)." | 3.71 | Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats. ( Konishi, Y; Murata, N; Sasaki, Y; Tsujiuchi, T; Tsutsumi, M, 2001) |
| "We previously found by chance that N-nitrosomorpholine (NMOR) given after a multi-carcinogenic treatment induces liver carcinomas with 56% lung metastasis, and it was confirmed that hepatocellular carcinoma (HCC) with 100% lung metastasis was produced by 24-week treatment with NMOR and additional treatment with diethylnitrosamine (DEN)." | 3.70 | Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model. ( Futakuchi, M; Hirose, M; Kato, K; Ogawa, K; Ogiso, T; Sano, M; Shirai, T, 1999) |
| " In this study we report that gavage administration of 200 mg/kg or 600 mg/kg CCM effectively suppressed diethylnitrosamine (DEN)-induced liver inflammation and hyperplasia in rats, as evidenced by histopathological examination." | 3.70 | Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. ( Cheng, AL; Chuang, SE; Kuo, ML; Lin, JK, 2000) |
| "A CK immunohistochemical study was carried out on histologic sections from hepatocellular carcinomas (HCCs) and preneoplastic lesions from 118 monkeys chronically dosed with diethylnitrosamine (DEN), using mAbs to CK 8, CK 18, CK 7, and CK 19." | 3.69 | Cytokeratin patterns of liver carcinomas induced by diethylnitrosamine in monkeys. ( Bocsi, J; Lapis, K; Sarosi, I; Thorgeirsson, UP, 1995) |
| "To determine whether a constitutive p53 deficiency would enhance the rate of development of chemically induced hepatocellular carcinoma, we treated groups of wild-type, p53-heterozygous (+/-), and null (-/-) male mice with a single dose of diethylnitrosamine at 12 d of age." | 3.69 | Hepatocarcinogenesis in p53-deficient mice. ( Kemp, CJ, 1995) |
| " Metallothionein (MT), an inducible metal-binding protein associated with tolerance to many metal including Cd, was not detected immunohistochemically in mouse liver tumors, even those undergoing Cd-induced necrosis, whereas the surrounding normal liver cells expressed high levels of MT after Cd exposure." | 3.69 | Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice. ( Cherian, MG; Diwan, BA; Goyer, RA; Moussa, M; Rehm, S; Waalkes, MP; Ward, JM, 1996) |
| "In rats with diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC), we studied in vivo gene transfer efficiency using intraportal injections of recombinant adenovirus carrying the lacZ reporter gene (AdCMVlacZ) and the therapeutic efficacy of adenovirus-mediated transfer of the thymidine kinase gene of the herpes simplex virus (HSV-tk) followed by ganciclovir (GCV) administration." | 3.69 | Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma. ( Bilbao, R; Bruña, O; Idoate, M; Prieto, J; Qian, C; Sangro, B; Vázquez, J, 1997) |
| "Formation and repair of O6-medG and N7-medG (O6- and N7-methyldeoxyguanosine) in glutathione S-transferase-P form (GST-P)-positive liver cell foci, nodules, primary hepatocellular carcinoma (HCC) and transplanted hepatocellular carcinoma (TRP) induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) were immunohistochemically assessed following a single exposure to dimethylnitrosamine (DMN)." | 3.68 | Decreased dimethylnitrosamine-induced O6- and N7-methyldeoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis. ( Asamoto, M; Iwase, T; Kato, T; Matsumoto, K; Montesano, R; Nagao, S; Ozaki, K; Tsuda, H; Wild, CP, 1993) |
| "The ability of diethylnitrosamine (DENA) to initiate and phenobarbital to promote altered-hepatocyte foci and hepatocellular carcinomas in C3H and C3B6F1 (C3H x C57BL/6) mice was compared to the extent of cell proliferation." | 3.68 | Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation. ( Pereira, MA, 1993) |
| "Exposure of female hepatitis B virus transgenic mice of lineage 50-4, which display liver injury secondary to overexpression of the gene for the large envelope polypeptide of hepatitis B virus, to the hepatocarcinogens aflatoxin and diethylnitrosamine produced more rapid and extensive evidence of nodule formation and oval cell proliferation, as well as the development of adenomas and primary hepatocellular carcinomas, than was seen in transgenic mice not exposed to carcinogens." | 3.68 | Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. ( Chisari, FV; Dunsford, HA; Hunt, JM; Sell, S, 1991) |
| "Cell nuclear DNA ploidy patterns were examined using cytofluorometry in hepatocellular carcinomas (HCC) induced by diethylnitrosamine (DEN) in rat and human HCC." | 3.67 | [Biological activity of hepatocellular carcinoma by analysing nuclear DNA ploidy patterns and using anti BrdU monoclonal antibody]. ( Jung-Rou, T, 1989) |
| " The animal models were Sewall Wright strain 13 guinea pigs with 3-methyl-cholanthrene (MCA)-induced fibrosarcomas and strain 2 guinea pigs with diethylnitrosamine (DEN)-induced hepatocarcinomas." | 3.66 | Guinea pig cell-mediated tumor immunity: the chromium release assay detects both cytolysis and serum blocking for syngeneic chemically-induced tumors. ( Blazkovec, AA; Miller, FR, 1979) |
| "2% N-ethyl-N-hydroxyethylnitrosamine (EHEN) for 2 weeks induced hepatocellular carcinoma in 3 and renal tubular cell tumors in 7 of 9 Wistar rats." | 3.66 | Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine. ( Hiasa, Y; Iwata, C; Ohshima, M; Tanikake, T, 1979) |
| "05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
| "Administration of 40 ppm diethylnitrosamine (DENA) in the drinking water for 10 weeks to male Fischer rats led to hepatocellular carcinoma in 100 percent with metastasis to the lung in 40 percent, of the animals living for the full experimental period of 20 weeks." | 3.65 | Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression. ( Madison, RM; Viguera, C; Ward, JM; Weisburger, EK; Weisburger, JH, 1975) |
| "The characteristic clostridial growth which is testable, after systemic administration of tetanus spores, as a positive tumour tetanus - correlation, was manifested by a highly selective tetanus lethality of rats with progressive hepatomas following induction with dimethylaminoazobenzene and diethylnitrosamine, respectively, as well as with methylcholanthren-induced fibrosarcomas of the rat." | 3.65 | [The tumor-tetanus assay--experimental studies on the biological differentiation between carcinogenesis and organ regeneration of the rat (author's transl)]. ( Fabricius, EA; Schneeweiss, U, 1975) |
| "Liver neoplasms were induced in medakas (Oryzias latipes) by the addition of diethylnitrosamine (DENA) to their aquarium water at levels of 15-135 ppm for 8 weeks." | 3.65 | Histologic and electron microscopy observations on diethylnitrosamine-induced hepatomas in small aquarium fish (Oryzias latipes). ( Ishikawa, T; Shimamine, T; Takayama, S, 1975) |
| "The frequency of metastases of malignant diethylnitrosamine-induced hepatomas and haemangioendotheliomas of the liver of female Sprague-Dawley rats (29%) was not influenced by application of acetyl-salicylic acid or phenprocoumon." | 3.65 | [Studies on the influence of anticoagulants on metastase formation of autochthonic hepatomas in the rat (author's transl)]. ( Schmähl, D, 1975) |
| "The effects of treatments with diethylnitrosamine (DENA) and hepatitis B virus (HBV) on macaque monkeys were investigated by virus serology and by light and electron microscopy." | 3.65 | Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus. ( Cabral, GA; Gyorkey, F; Gyorkey, P; Hollinger, FB; Melnick, JL; Mirkovic, R, 1977) |
| "In fact, liver cancer often develops in the context of chronic liver injury." | 2.53 | Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. ( Dhar, D; Karin, M, 2016) |
| "Hepatocellular carcinoma is the second most cause of death among the various cancers worldwide." | 1.91 | Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats. ( Amudha, P; Jayalakshmi, M; Poojitha, BN; Vidya, R, 2023) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 1.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| " However, its therapeutic activity is limited by poor bioavailability and unpredictable distribution." | 1.91 | Lactosylated Chitosan Nanoparticles Potentiate the Anticancer Effects of Telmisartan In Vitro and in a ( El-Gizawy, SA; Essa, EA; Kira, AY; Nasr, M; Saber, S, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of hepatocellular carcinoma (HCC)." | 1.72 | Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet. ( Chun, HJ; Kwon, YH; Shim, YJ, 2022) |
| "In the present study, hepatocellular cancer (HCC) induced by diethylnitrosamine (DEN) in rats and then treated with the new chromene derivative and the parameters TNF-α, VEGF, p53, Cyt C, MMP-9, Bcl2, and Bax were measured." | 1.72 | In vivo Study of a Newly Synthesized Chromen-4-one Derivative as an Antitumor Agent against HCC. ( El-Mezayen, HA; Mahdy, EME; Mansour, SZ; Mohamed, SA; Nabeel, AI, 2022) |
| "Alcohol is a well-known risk factor for hepatocellular carcinoma." | 1.72 | Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis. ( Ballabio, A; Chao, X; Ding, WX; Hlobik, M; Ni, HM; Wang, S, 2022) |
| "ADI can inhibit a lot of CYP450 enzyme, so it may reduce the dosage of chemotherapeutic drugs to reach the required plasma concentration of chemotherapeutic drugs, which is of great significance for the combination of anti-tumor chemotherapeutic drugs and is worthy of further in-depth study and clinical attention." | 1.72 | Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats. ( He, Y; Huang, Y; Jin, Y; Li, Y; Liu, W; Lu, Y; Pan, J; Wang, Y; Zheng, L, 2022) |
| "Prunetin (PRU) is an O-methylated flavonoid that is present in various natural plants and a primary significant compound found in isoflavone." | 1.72 | Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats. ( Chen, H; Li, G; Qi, L; Tian, G, 2022) |
| "The arbutin treatment effectively improved body weight and reduced liver weight in animals with DEN-provoked liver cancer." | 1.72 | Anticancer Effect of Arbutin on Diethylnitrosamine-Induced Liver Carcinoma in Rats via the GRP and GADD Pathway. ( Chen, X; Dong, P; Huang, Z; Liu, H; Zeng, X, 2022) |
| "Boron has great potential to reduce the effects of oxidative stress, which may help it inhibit the progression of HCC." | 1.72 | Boron attenuated diethylnitrosamine induced hepatocellular carcinoma in C3H/HeN mice via alteration of oxidative stress and apoptotic pathway. ( Chen, J; Huang, H; Wang, J; Wei, Y; Wu, L; Yi, JK; Yin, X, 2022) |
| "BALB/c mice model of hepatocarcinogenesis was established using N-nitrosodiethylamine as a carcinogen (200 mg/kg b." | 1.72 | MitoQ demonstrates connexin- and p53-mediated cancer chemoprevention in N-nitrosodiethylamine-induced hepatocarcinogenesis rodent model. ( Bharati, S; De, S; Qsee, HS; Tambe, PK, 2022) |
| "Diethylnitrosamine-induced hepatocellular carcinomas were then investigated in lean and diet-induced obese miR-22-deficient mice." | 1.72 | MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver. ( Ay, AS; Correia de Sousa, M; Delangre, E; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Sempoux, C; Sobolewski, C, 2022) |
| "Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality." | 1.62 | Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma. ( Balaraman, G; Krishnan, P; Mari, A; Salam, S; Sirajduddin, I; Subramaniam, N; Sundaram, J; Thiruvengadam, D, 2021) |
| " The study aimed to investigate the pharmacokinetic mechanism of herb-drug interactions between ADI and DOX in a rat model of HCC." | 1.62 | Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma. ( Cao, C; Chen, S; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zhang, S; Zhu, X, 2021) |
| " As a competitor of SHBG-androgen binding, EE2 could bind with SHBG and increase the bioavailability of androgen." | 1.62 | Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin. ( Heo, JH; Hong, EJ; Jeong, SH; Jo, SL; Ko, JW; Kwun, HJ; Lee, SR, 2021) |
| "TREM-2 plays a protective role in hepatocarcinogenesis via different pleiotropic effects, suggesting that TREM-2 agonism should be investigated as it might beneficially impact HCC pathogenesis in a multifactorial manner." | 1.62 | TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. ( Agirre-Lizaso, A; Andersen, JB; Aspichueta, P; Azkargorta, M; Banales, JM; Bujanda, L; Elortza, F; Esparza-Baquer, A; Hijona, E; Jimenez-Agüero, R; Knapp, S; La Casta, A; Labiano, I; Landa, A; Mann, DA; Munoz-Garrido, P; O'Rourke, CJ; Oakley, F; Perugorria, MJ; Riaño, I; Rodrigues, PM; Schabbauer, G; Sharif, O; Vogel, A; Zaki, MYW; Zhuravleva, E, 2021) |
| "The role of TTP in nonalcoholic steatohepatitis and HCC development was further examined through in vivo/vitro approaches using liver-specific TTP knockout mice and a panel of hepatic cancer cells." | 1.62 | Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. ( Bejuy, O; Berthou, F; Blackshear, PJ; Colin, DJ; Correia de Sousa, M; De Vito, C; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Rubbia-Brandt, L; Sobolewski, C, 2021) |
| "Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide." | 1.62 | Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis. ( Fares, NH; Mahmoud, AA; Mahmoud, YI; Shehata, AMM, 2021) |
| "Phenobarbital treated mice showed damped corticosterone levels and a less stable 24 hours activity rhythm as well as an increase in activity during the light phase, reminiscent of sleep disruption." | 1.62 | Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model. ( Ali, AAH; Hassan, SA; Jänicke, RU; Korf, HW; Pfeffer, M; Sohn, D; von Gall, C; Yassine, M, 2021) |
| "Hepatocellular carcinoma in nonalcoholic steatohepatitis is caused by the complex factors of inflammation, fibrosis and microbiomes." | 1.62 | Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine. ( Fujishiro, M; Honda, T; Ishigami, M; Ishizu, Y; Ito, T; Kato, A; Kawashima, H; Kuzuya, T; Ma, L; Nakamura, M; Tsuji, NM; Yamamoto, K; Yokoyama, S, 2021) |
| "In in vitro and in vivo hepatocellular carcinoma mouse models it can significantly suppress primary tumor growth, prevent distant metastasis/cell migration, reduce angiogenesis, and normalize the immunosuppressive tumor microenvironment by reducing tumor-associated macrophages (TAMs) infiltration, reprogramming TAMs toward an immunostimulatory phenotype and promoting cytotoxic T cell infiltration into tumor." | 1.62 | A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment. ( Chang, CC; Chen, Y; Chou, MC; Dinh, TK; Huang, JK; Huang, KW; Jan, JJ; Ke, YY; Lee, CJ; Shia, KS; Shiue, TY; Song, JS; Sung, YC; Ta, YN; Wu, CH; Yeh, KC; Yeh, TK, 2021) |
| " Because the administration of 2-acetylaminofluorene (2AAF) followed by a partial hepatectomy, selectively induces the HPC proliferation, we investigated the effects of chronic 2AAF administration on the HCC development caused by the chronic administration of the carcinogen diethylnitrosamine (DEN) for 16 weeks in the rat." | 1.62 | Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo. ( Arellanes-Robledo, J; Castro-Gil, MP; Del-Pozo-Jauner, L; Gabiño-López, NB; López-Torres, CD; Pérez-Carreón, JI; Quintanar-Jurado, V; Sánchez-Rodríguez, R; Torres-Mena, JE; Villa-Treviño, S, 2021) |
| "Alogliptin is an anti-diabetic that may have effective anticancer properties against many types of malignancies." | 1.62 | Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. ( Abd Elmaaboud, MA; Arab, HH; Kabel, AM, 2021) |
| "Liver cancer was induced in mice with hepatocyte-specific disruption of Myc and control mice by administration of diethylnitrosamine." | 1.62 | Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. ( Cai, J; Chen, L; Gao, Y; Gonzalez, FJ; Guo, X; Jiang, J; Krausz, KW; Liu, W; Luo, Y; Qu, A; Sun, L; Takahashi, S; Tang, W; Wang, Y; Xie, C; Yang, S; Yang, Y, 2021) |
| " However, the bioavailability of ABZ is very poor." | 1.62 | Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression. ( Amin, NA; Batiha, GE; El-Ahwany, E; El-Rous, MA; Elagamy, HI; Elewa, YHA; Elsergany, RN; Girgis, S; Gobba, NA; Hafez, AM; Kaddah, MMY; Kamal, I; Khodir, AE; Mahmoud, MH; Mourad, AAE; Nasr, M; Saad, AS; Saber, S; Shata, A, 2021) |
| "We compared gene expression profiles of Morris Hepatoma (MH3924a) and DEN (diethylnitrosamine)-induced HCC models to those of liver tissues from normal and rapidly regenerating liver models, and performed gain- and loss-of-function studies of the identified gene targets for their roles in cancer cell proliferation in vitro and in vivo." | 1.56 | Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis. ( Chow, P; Denil, S; Ding, Z; Ericksen, RE; Escande-Beillard, N; Gruenewald, S; Haegebarth, A; Han, W; Lee, QY; Loh, A; Reversade, B; Steckel, M; Toh, HC; Wai Ho, TS, 2020) |
| "All mice administered oral DEN developed liver fibrosis, liver cirrhosis and hepatocellular carcinoma (HCC)." | 1.56 | Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis. ( Bai, L; Chen, Q; Jiang, S; Lai, J; Yang, W; You, X; Zhang, H, 2020) |
| "ET in the prevention of liver cancer is poorly understood." | 1.56 | Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine. ( Cao, L; Ding, S; Ji, B; Li, L; Qi, Z; Zhang, X, 2020) |
| " Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation." | 1.56 | Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020) |
| "And Wrh-f2 developed stable pulmonary metastasis." | 1.56 | Establishment of rat liver cancer cell lines with different metastatic potential. ( Feng, X; Hou, J; Liu, SF; Song, L; Zhang, HL; Zhang, JG; Zheng, L, 2020) |
| "Follow-up screening was performed in hepatocellular carcinoma with a focused CRISPR library targeting imaging-related genes." | 1.56 | Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer. ( Ackerman, D; Gade, TPF; Johnson, O; Mercadante, M; Perkons, NR; Pilla, G; Profka, E, 2020) |
| "Diethylnitrosamine (DEN) was used to induce HCC in a high-fat diet (HFD)-induced multigenerational obesity model." | 1.56 | Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p. ( Geng, M; Huang, K; Liu, S; Liu, Y; Petersen, RB; Sun, Y; Wang, Q; Wei, Y; Yue, J; Zhang, Y; Zheng, L, 2020) |
| "Diethylnitrosamine was widely employed as a carcinogenic agent to stimulate the cancer in animal models." | 1.56 | Vicenin-2 Treatment Attenuated the Diethylnitrosamine-Induced Liver Carcinoma and Oxidative Stress through Increased Apoptotic Protein Expression in Experimental Rats. ( Bolla, SR; Chen, Y; Gong, G; Li, Y; Veeraraghavan, VP; Xu, C; Zhang, C; Zhang, M, 2020) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 1.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| "The present study used human hepatoma cell lines and rats with diethylnitrosamine (DEN)‑induced HCC as models to investigate the association between the effect of EGCG on liver cancer and regulation of the p21waf1/Cip1/CDC25A axis." | 1.56 | Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A. ( An, H; Cai, Z; Cao, J; Chen, N; Li, K; Li, Y; Luo, A; Peng, Y; Tang, Y; Tao, H, 2020) |
| "Treatment of DEN-induced hepatocellular carcinoma Wistar rats with the extract caused significant (p < 0." | 1.56 | Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats. ( Adebayo, AH; Adelani, IB; Adesina, GO; Edokwe, CB; Metibemu, DS; Oseha, OE; Yakubu, OF, 2020) |
| "GSTZ1 deficiency significantly promoted hepatoma cell proliferation and aerobic glycolysis in HCC cells." | 1.51 | GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. ( Chen, C; Lei, C; Li, J; Liang, L; Tang, N; Wang, K; Wang, Q; Xia, J; Yang, F; Yang, Y, 2019) |
| "Sorafenib (SO) is a multi-kinase inhibitor that targets upstream signals in the MAPK pathway." | 1.51 | Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma. ( Ghanim, AMH; Saber, S; Younis, NS, 2019) |
| "Echinacoside (ECH) is a phenylethanoid glycoside extracted from a Chinese herbal medicine, Cistanches salsa." | 1.51 | Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells. ( Ni, J; Song, Y; Wang, G; Xia, W; Ye, Y; Zhuang, J, 2019) |
| "Identification of events leading to hepatocellular carcinoma (HCC) progression is essential for understanding its pathophysiology." | 1.51 | Elevated Expression of A-Raf and FA2H in Hepatocellular Carcinoma is Associated with Lipid Metabolism Dysregulation and Cancer Progression. ( Jain, SK; Ranjpour, M; Wajid, S, 2019) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 1.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| " Due to poor solubility and low bioavailability SYL lacks satisfactory therapeutic value thus designing a suitable and effective delivery system of SYL can led to improved therapeutic potential." | 1.51 | Dextrose modified bilosomes for peroral delivery: improved therapeutic potential and stability of silymarin in diethylnitrosamine-induced hepatic carcinoma in rats. ( Dwivedi, M; Parashar, P; Rana, P; Saraf, SA, 2019) |
| "Hepatitis and hepatocellular carcinoma are serious human diseases." | 1.51 | Extracts of Qizhu decoction inhibit hepatitis and hepatocellular carcinoma in vitro and in C57BL/6 mice by suppressing NF-κB signaling. ( Fang, NY; Shen, JJ; Wan, LF; Wang, YH; Xue, BY; Yuan, X; Zhao, W, 2019) |
| "Hepatocellular carcinoma is the most frequent kind of primary liver cancer and occurs mostly in patients with chronic liver disease and cirrhosis." | 1.51 | Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway. ( Cui, G; Shang, X; Wang, N; Yang, G; Zhao, H; Zhao, L, 2019) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 1.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "In the NAFLD pigs, hepatic histology of nonalcoholic steatohepatitis (NASH) was observed at 36 weeks, and HCC developed at 60 weeks." | 1.51 | Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study. ( Aizawa, N; Hatano, E; Iguchi, K; Iijima, H; Ikegawa, M; Kawaguchi, H; Nakamura, N; Nishiguchi, S; Ohtsu, I; Okuda, Y; Sakurai, T; Sato, M; Seo, S; Taura, K; Tomono, T; Uemoto, S; Wada, S, 2019) |
| "Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC)." | 1.48 | Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis. ( Inoue-Yamauchi, A; Itagaki, H; Oda, H, 2018) |
| "Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis." | 1.48 | In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa ( Fathy, M; Nikaido, T, 2018) |
| "Obesity is associated with both endoplasmic reticulum (ER) stress and chronic metabolic inflammation." | 1.48 | Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice. ( Cai, J; Chen, T; Dai, J; Fang, J; Feng, Y; Liu, J; Liu, Y; Lv, S; Rui, L; Shan, B; Wang, Y; Wu, Y; Xia, Z; Xie, D; Zheng, L, 2018) |
| "The most common form of liver cancer is hepatocellular carcinoma (HCC)." | 1.48 | WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia. ( Abu-Remaileh, M; Aqeilan, RI; Khalaileh, A; Pikarsky, E, 2018) |
| "In a nutritional model of hepatocarcinogenesis, the protein Nrf2 is frequently mutated/activated at early steps of the tumorigenic process." | 1.48 | Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. ( Columbano, A; Orrù, C; Perra, A; Szydlowska, M; Taguchi, K; Yamamoto, M; Zavattari, P, 2018) |
| "Hepatocellular carcinoma is a common primary malignancy of hepatocytes that has caused many fatalities globally." | 1.48 | Inhibitory effects of mushroom extracts on progression of carcinogenesis in mice. ( Omwandho, C; Wasonga, C, 2018) |
| "In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous treatment." | 1.48 | Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice. ( Álvarez, ML; Arboatti, AS; Carnovale, CE; Francés, DEA; Lambertucci, F; Monti, J; Pisani, G; Ronco, MT; Sedlmeier, MG, 2018) |
| "Diethylnitrosamine was used to induce liver cancer in a rat model." | 1.48 | Correlation between HSD17B4 expression in rat liver cancer tissues and inflammation or proliferation. ( Lin, Z; Pan, LC; Xiao, HY; Yin, WJ, 2018) |
| "In the rat hepatocarcinogenesis model, unexpectedly, CYP2E1 activity was found to decrease from hepatofibrosis to hepatocarcinogenesis." | 1.48 | From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor. ( Gao, J; Gao, N; Jin, H; Li, J; Qiao, HL; Wang, GJ; Wang, Z; Wen, Q; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| "The urgent unmet need for hepatocellular carcinoma (HCC) therapies is addressed here by characterising a novel mouse model of HCC in the context of ongoing liver damage and overnutrition." | 1.48 | Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma. ( Chen, J; Gorrell, MD; Henderson, JM; Kench, JG; McCaughan, GW; Polak, N; Roediger, B; Weninger, W; Zhang, HE, 2018) |
| "Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC)." | 1.48 | Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis. ( Dozmorov, M; Fisher, PB; Ghosh, S; Jariwala, N; Lai, Z; Mendoza, RG; Mukhopadhyay, ND; Robertson, CL; Sarkar, D; Subler, MA; Windle, JJ, 2018) |
| "At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally." | 1.48 | The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice. ( Chen, XZ; Li, XJ; Li, YS; Shang, HC; Tang, HB; Tian, GH; Zhang, WK, 2018) |
| "Both incidence and death rate due to liver cancer have increased in the United States." | 1.48 | Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes. ( Aizawa, K; Fu, M; Hiroyuki, S; Hu, KQ; Li, CC; Liu, C; Takahashi, S; Wang, XD; Wu, G; Xia, H; Zhao, L, 2018) |
| "In the DEN-treated mice, AICAR treatment reduced tumorigenesis, IL-6 signaling, and STAT3 activation." | 1.48 | The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN). ( Gao, J; Jiang, G; Xiong, D; Xiong, R; Yin, T; Yin, Z; Zhang, S; Zhang, X; Zhao, W, 2018) |
| "Human hepatocellular carcinomas (HCCs), which arise on a background of chronic liver damage and inflammation, express c-Fos, a component of the AP-1 transcription factor." | 1.46 | Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation. ( Bakiri, L; Campos-Olivas, R; Dienes, HP; Graña, O; Guío-Carrión, A; Hamacher, R; Hasenfuss, SC; Martinez, L; Thomsen, MK; Wagner, EF, 2017) |
| "Determining the origin of liver cancer stem cells is important for treating hepatocellular carcinoma." | 1.46 | Tg737 regulates epithelial-mesenchymal transition and cancer stem cell properties via a negative feedback circuit between Snail and HNF4α during liver stem cell malignant transformation. ( Bian, Z; Chen, C; Dai, B; Huang, Q; Liu, W; Pu, M; Qu, X; Shen, L; Tang, H; Tao, K; Zhao, G, 2017) |
| "The global burden of hepatocellular carcinoma is increasing; actually, it is estimated as 750,000 new cases annually." | 1.46 | Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study. ( Aglan, HA; Ahmed, HH; El-Toumy, SA; Mahmoud, NS, 2017) |
| "Non-alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of conditions, ranging from non-progressive bland steatosis to hepatocarcinoma." | 1.46 | Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. ( Bischetti, S; Casagrande, V; Federici, M; Mauriello, A; Mavilio, M; Menghini, R, 2017) |
| "Hepatocellular carcinoma was induced with 20 mg diethylnitrosamine/kg BW." | 1.46 | Gamma-irradiated β-glucan modulates signaling molecular targets of hepatocellular carcinoma in rats. ( Elsonbaty, SM; Moawed, FS; Zahran, WE, 2017) |
| "Rats from all groups were assessed for liver cancer progression or inhibition by evaluating histological, biochemical, antioxidant enzyme status, cytokines and gene expression profiles." | 1.46 | Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats. ( Abuzenadah, A; Al-Qahtani, M; Barbour, E; Chaudhary, A; Kalamegam, G; Khan, F; Khan, TJ; Kumosani, T; Pushparaj, PN, 2017) |
| "Treatment with crocin-coated MNPs was associated with regression of precancerous lesions, significant upregulation of apoptotic cells and downregulation of Bcl-2 labeling and markers of cell proliferation, inflammation, oxidative stress and angiogenesis." | 1.46 | Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles. ( Amin, A; El-Kharrag, R; Greish, Y; Hisaindee, S; Karam, SM, 2017) |
| "The high recurrence/metastasis of HCC is the main cause of death for HCC patients after liver resection." | 1.46 | miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver. ( Chen, XB; Feng, L; Tang, JW; Xu, LL; Xu, MQ; Yi, PS; Zhang, M; Zheng, XB, 2017) |
| "Blocking lipogenesis in cultured liver cancer cells is sufficient to decrease cell viability; however, it is not known whether blocking lipogenesis in vivo can prevent liver tumorigenesis." | 1.46 | Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. ( Breen, DS; Byrne, FL; Caldwell, SH; Chow, JD; Cooney, GJ; Hargett, SR; Hoehn, KL; James, DE; Lackner, C; Lahiri, S; Nelson, ME; Olzomer, EM; Slack-Davis, JK; Turner, N; Wu, LE, 2017) |
| "While gender differences in hepatocellular carcinoma (HCC) are profound, the mechanism is unclear." | 1.43 | Testosterone regulation of cyclin E kinase: A key factor in determining gender differences in hepatocarcinogenesis. ( Barn, VA; Blackburn, AC; Board, P; Farrell, GC; Pok, S; Teoh, NC; Wong, HJ, 2016) |
| "Hepatocellular carcinoma is increasingly important in the United States as the incidence rate rose over the last 30 years." | 1.43 | DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status. ( Drinkwater, NR; Hanes, MA; Herbert, DC; Herzig, MC; Hildreth, K; McMahan, CA; Reddick, RL; Reddick, T; Street, K; Walter, CA; Zavadil, JA, 2016) |
| "Without treatment, NAFLD may progress to hepatocellular carcinoma (HCC), a cancer with a high mortality rate." | 1.43 | Dietary Broccoli Lessens Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and Fed a Western or Control Diet. ( Chen, YJ; Jeffery, EH; Wallig, MA, 2016) |
| "Bid participates in hepatic carcinogenesis but the mechanism is not fully understood." | 1.43 | Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. ( Chen, X; Dong, Z; Khambu, B; Luo, J; Michalopoulos, GK; Wu, S; Yan, S; Yin, XM; Yu, C, 2016) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 1.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "The development of hepatocellular carcinoma (HCC) is a common consequence of advanced liver fibrosis but the interactions between fibrogenesis and carcinogenesis are still poorly understood." | 1.43 | TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver. ( Bohner, A; Dapito, DH; Lammert, F; Schwabe, RF; Weber, SN, 2016) |
| "Dieckol (DEK) is a naturally occuring phlorotannins found in marine brown algae Ecklonia cava which is attributed with various pharmacological properties." | 1.43 | Protective effects of dieckol on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. ( Duraikannu, A; Fredrick, WS; Kodisundaram, P; Ravichandran, S; Sadeeshkumar, V; Sivaperumal, R, 2016) |
| "Diethylnitrosamine (DEN) was used to induce pre-carcinoma and early HCC nodules in the experimental group." | 1.43 | Detection and differentiation of early hepatocellular carcinoma from cirrhosis using CT perfusion in a rat liver model. ( Feng, GL; Jiang, HJ; Li, DQ; Li, JP; Wan, Y; Wang, HB; Zhao, DL, 2016) |
| "The impact of gp96 status on hepatic carcinogenesis in response to diethyl-nitrosoamine (DENA) was probed." | 1.42 | Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. ( Chiosis, G; Clarke, CJ; Cowart, LA; Drake, RR; Hannun, YA; Jones, E; Li, Z; Liu, B; Ogretmen, B; Rachidi, S; Sun, S; Wu, BX, 2015) |
| "After DEN-induced hepatocellular carcinoma (HCC) in rats showed increased phosphorylation of JNK1/2, p38, and ERK1/2, we next antagonized TGF-β1-induced phosphorylation of JNK1/2, p38, ERK1/2, Smad2/3 signaling in HepG2 cells using SP600125, SB203580, and PD98059, respectively." | 1.42 | MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells. ( Boye, A; He, S; Jiang, Y; Kan, H; Wu, C; Yang, X; Yang, Y, 2015) |
| "Chronic liver inflammation is a crucial event in the development and growth of hepatocellular carcinoma (HCC)." | 1.42 | Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model. ( Al Masaoudi, M; Cubero, FJ; Gassler, N; Hatting, M; Liedtke, C; Nevzorova, YA; Peng, J; Sellge, G; Spannbauer, M; Trautwein, C, 2015) |
| "Caudatin is a potential antitumor agent isolated from the traditional Chinese medicine "baishouwu", which was the root tuber of Cynanchum auriculatum Royle ex Wight." | 1.42 | Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats. ( Ding, Y; Peng, Y, 2015) |
| "At present, the treatment of hepatocellular carcinoma (HCC) is an international problem." | 1.42 | Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Chen, Q; Li, Y; Liu, W; Tang, H; Yang, X; Zhao, X, 2015) |
| "The treatment with astemizole prevented diethylnitrosamine (DEN)-induced rat HCC development in vivo (followed by studying γ-glutamyl transpeptidase (GGT) activity)." | 1.42 | Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1 channels as potential early-stage markers of HCC. ( Acuña-Macías, I; Camacho, J; Caro-Sánchez, CH; Chiliquinga, AJ; de Guadalupe Chávez-López, M; Díaz-Chávez, J; Gariglio, P; Hernández-Gallegos, E; Herrera, LA; Pérez-Carreón, JI; Zuñiga-García, V, 2015) |
| "Experimentally induced hepatocellular carcinoma is considered one of the representative laboratory models for studying this process." | 1.42 | Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells. ( Cai, JC; Cathopoulis, T; Han, R; Li, X; Liu, F; Liu, GY; Lu, K; Luo, G; Peng, B; Shi, SL; Yang, L, 2015) |
| "Fgl1 expression is decreased in hepatocellular carcinoma (HCC) and its loss correlates with a poorly differentiated phenotype." | 1.42 | Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. ( Bronson, RT; Cohen, DE; Demchev, V; Desai, A; Hornick, JL; Nayeb-Hashemi, H; Ukomadu, C, 2015) |
| "Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC)." | 1.42 | Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis. ( Chung, YA; Ham, HJ; Jang, KS; Jung, YJ; Lee, J; Lee, JH; Maeng, LS; Park, MS; Park, SI, 2015) |
| "We found that loss of MnSOD in hepatoma cells contributed to their conversion toward a more malignant phenotype, affecting all cellular properties generally associated with metabolic transformation and tumorigenesis." | 1.42 | Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. ( Dombrowski, F; Görlach, A; Jakupovic, M; Kietzmann, T; Konzack, A; Kubaichuk, K; Miinalainen, I; Sormunen, R, 2015) |
| "Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date." | 1.42 | Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients. ( Hu, C; Huang, X; Lin, X; Niu, J; Tan, Y; Wang, H; Wang, X; Yin, P; Zeng, J; Zhou, L, 2015) |
| "Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 1.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
| "Alcoholic liver disease, chronic hepatitis B and chronic hepatitis C are the most common underlying liver diseases." | 1.40 | Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53. ( Calabrese, D; Dietsche, T; Dill, MT; Duong, FH; Heim, MH; Ketterer, S; Makowska, Z; Matter, MS; Terracciano, L, 2014) |
| "A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used." | 1.40 | Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014) |
| "Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1α hepatic expression." | 1.40 | Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Hamed, O; Kazem, A; Nasr, M; Selima, E, 2014) |
| "Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis." | 1.40 | The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014) |
| "Interestingly, HFD, which induced hyperlipidemia and hepatic steatosis, attenuated DEN-related malnutrition and fibrosis progression in HFD + DEN group during 10-14 weeks." | 1.40 | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. ( Ding, WJ; Duan, XY; Fan, JG; Pan, Q; Qiao, L; Yan, SY, 2014) |
| "Molecular mechanisms responsible for hepatocellular carcinoma (HCC) remain largely unknown." | 1.40 | Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. ( Bakiri, L; Djouder, N; Gomes, AL; Graña, O; Pisano, DG; Rodriguez-Justo, M; Ruppen, I; Sheshappanavar, V; Tummala, KS; Wagner, EF; Ximénez-Embún, P; Yilmaz, M, 2014) |
| "The ability to treat hepatocellular carcinoma was measured by comparing biochemical serum markers such as serum alanine aminotransferase, serum aspartate aminotransferase, serum alkaline phosphatase, and the specific marker for hepatocellular carcinoma, alpha fetoprotein." | 1.39 | Anticancer effect of ursolic acid stearoyl glucoside in chemically induced hepatocellular carcinoma. ( Afzal, M; Ahmad, A; Al-Abbasi, FA; Anwar, F; Kazmi, I; Narooka, AR; Singh, R, 2013) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 1.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| "In human hepatocellular carcinoma tumors, high levels of CXCR4 always correlated with activation of the TGF-β pathway, a less differentiated phenotype, and a cirrhotic background." | 1.39 | Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells. ( Bertran, E; Caja, L; Crosas-Molist, E; Egea, G; Fabregat, I; Lastra, R; Lopez-Luque, J; Navarro, E; Ramos, E; Sancho, P; Serrano, T, 2013) |
| "Real-time analyses of hepatocellular carcinoma were performed in living mice to assess the applicability of probe electrospray ionization-mass spectrometry (PESI-MS) in medical diagnosis." | 1.39 | Real-time diagnosis of chemically induced hepatocellular carcinoma using a novel mass spectrometry-based technique. ( Chen, LC; Fujii, H; Hara, M; Hiraoka, K; Mandal, MK; Takeda, S; Tanabe, K; Yoshimura, K, 2013) |
| "Treatment options for hepatocellular carcinoma using chemotherapeutics at intermediate and advanced stages of disease are limited as patients most rapidly escape from therapy and succumb to disease progression." | 1.39 | Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance. ( Berger, W; Grubinger, M; Gucky, T; Haider, C; Jorda, R; Kryštof, V; Miklos, W; Mikulits, W; Řezníčková, E; Rotheneder, H; Strnad, M; Weiss, TS; Zatloukal, M, 2013) |
| "Phenobarbital (PB) is a cytochrome P450 (CYP) 2B inducer, and piperonyl butoxide (PBO) is a CYP1A/2B inducer." | 1.39 | Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide. ( Akane, H; Itahashi, M; Mitsumori, K; Morita, R; Nakane, F; Shibutani, M; Shiraki, A; Suzuki, K; Yafune, A, 2013) |
| "The findings suggest that RGP prevents hepatocellular carcinoma by suppressing the marked increase in the levels of serum marker enzymes, and suppresses the free radical by scavenging hydroxyl radicals." | 1.39 | Anticancer potential of rhamnocitrin 4'-β-D-galactopyranoside against N-diethylnitrosamine-induced hepatocellular carcinoma in rats. ( Ahmad, K; Ahmad, P; Al-Harbi, NO; Alam, MJ; Imam, F; Iqbal, M; Khusroo, MJ; Rahman, RU; Saleem, S; Shaharyar, MA, 2013) |
| "Group-II animals were kept untreated as hepatocellular carcinoma control." | 1.39 | Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats. ( Jhala, M; Joseph, JP; Kumar, P; Raval, SK; Sadariya, KA, 2013) |
| "Liver cancer, predominantly hepatocellular carcinoma (HCC), represents a complex and fatal malignancy driven primarily by oxidative stress and inflammation." | 1.39 | Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis. ( Bhatia, D; Bishayee, A; Darvesh, AS; Meszaros, JG; Ohanyan, V; Thoppil, RJ, 2013) |
| "Diethylnitrosamine (DEN) is a well known carcinogenic substance, which induces hepatic carcinoma." | 1.38 | Anticarcinogenic activity of nanoencapsulated quercetin in combating diethylnitrosamine-induced hepatocarcinoma in rats. ( Das, N; Ghosh, A; Ghosh, D; Mandal, AK; Sarkar, S; Thakur Choudhury, S, 2012) |
| "Hepatocellular carcinoma is becoming one of the most prominent types of cancer in the world." | 1.38 | Activity of tumor necrosis factor-α blocked by phytoglycoprotein (38 kDa) at initiation stage in N-nitrosodiethylamine-induced ICR mice. ( Lee, J; Lim, KT, 2012) |
| "Hepatocellular carcinoma was induced in animals of groups II and III with 0." | 1.38 | Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced hepatocellular carcinoma. ( Devaraj, SN; Shilpa, PN; Venkatabalasubramanian, S, 2012) |
| "This experiment was designed to compare the effect of two selenium sources at the dosage of therapeutic level on hepatocarcinogenesis and angiogenic cytokines in DEN-induced hepatocarcinoma rats to further approach their possible anticancer's mechanism." | 1.38 | Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. ( Liu, JG; Liu, YJ; Liu, YW; Wang, XL; Zhao, HJ, 2012) |
| "Decreased KLF6 expression in human hepatocellular carcinoma (HCC) correlates with increased mortality, but the contribution of increased SV1 is unknown." | 1.38 | Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing. ( Cohen-Naftaly, M; Friedman, SL; Hannivoort, R; Kocabayoglu, P; Lee, YA; M Llovet, J; Narla, G; Thung, SN; Vetter, D; Villanueva, A, 2012) |
| "Patients with liver cirrhosis and HCC had significantly increased serum endotoxin levels." | 1.38 | Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. ( Chen, HY; Dai, RY; He, YQ; Li, YQ; Li, Z; Lin, Y; Liu, Q; Qiu, BJ; Shan, L; Tan, YX; Tang, L; Wang, C; Wang, HY; Wu, FQ; Wu, H; Yan, HX; Yang, W; Yu, LX; Zhai, B; Zhang, HL; Zheng, LY, 2012) |
| "Liver tumor, especially hepatocellular carcinoma (HCC), is closely associated with chronic inflammation." | 1.38 | Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. ( Gan, Y; He, C; Huang, W; Lou, G; Meng, Z; Ness, CV; Wang, X; Wu, J; Xu, R; Yu, H; Zhang, Y; Zhou, H, 2012) |
| "Hepatocellular carcinoma is one of the most common cancers and lethal diseases in the world." | 1.38 | Myrtenal, a natural monoterpene, down-regulates TNF-α expression and suppresses carcinogen-induced hepatocellular carcinoma in rats. ( Babu, LH; Balasubramanian, MP; Perumal, S, 2012) |
| "The levels of liver cancer markers, including α-fetoprotein and carcinoembryonic antigen, were substantially increased by NDEA treatment." | 1.38 | Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats. ( Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M, 2012) |
| "Hepatocellular carcinoma was induced by single intraperitoneal injection of N-nitrosodiethylamine (NDEA) in normal saline at a dose of 200 mg/kg body weight followed by weekly subcutaneous injections of CCl(4)(3 mL/kg/week) for 6 weeks, as the promoter of carcinogenic effect." | 1.38 | Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl4-induced hepatocellular carcinoma in Wistar rats. ( Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M, 2012) |
| "A genetic basis of hepatocellular carcinoma (HCC) has been well-established and major signaling pathways, such as p53, Wnt-signaling, transforming growth factor-β (TGF-β) and Ras pathways, have been identified to be essential to HCC development." | 1.37 | Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis. ( Galle, PR; Hansen, T; Kanzler, S; Longerich, T; Maass, T; Mann, A; Schirmacher, P; Strand, D; Teufel, A; Thieringer, FR, 2011) |
| " At day 0, the fertilized eggs of the dosed groups were injected with 1 (LD) or 4 (HD) mg/egg (about 12." | 1.37 | Production of liver preneoplasia and gallbladder agenesis in turkey fetuses administered diethylnitrosamine. ( Brunnemann, KD; Enzmann, HG; Iatropoulos, MJ; Smart, DJ; Williams, GM, 2011) |
| " These results provide a rationale for long-term MET dosing in future clinical trials of HCC treatment." | 1.37 | Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma. ( Bae, SH; Choi, JY; Jang, JW; Jung, CK; Kwon, JH; Park, ST; Yoon, SK; You, CR, 2011) |
| "Inactivation of KLF6 is common in hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) infection, thereby abrogating its normal antiproliferative activity in liver cells." | 1.37 | Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation. ( Friedman, SL; Hannivoort, R; Hoshida, Y; Lee, UE; Llovet, JM; Narla, G; Oren, M; Tarocchi, M; Vetter, D; Villanueva, A, 2011) |
| "A small animal imaging system for hepatocellular carcinoma (HCC)-specific reporter gene expression will enable monitoring of carcinogenesis or therapeutic intervention in vivo." | 1.37 | Non-invasive monitoring of hepatocellular carcinoma in transgenic mouse with bioluminescent imaging. ( Cheon, GJ; Kang, JH; Kim, KI; Kim, KM; Lee, TS; Lee, YJ; Lim, SM; Nahm, SS; Park, JH; Park, YS, 2011) |
| "Phosphorylated STAT3 was found in human hepatocellular carcinoma tissue samples and was expressed in tumor cells and also in monocytes." | 1.37 | STAT3 activation in monocytes accelerates liver cancer progression. ( Li, J; Meng, XL; Wu, WY; Wu, ZS; Zhang, CL, 2011) |
| "p53 Mutations are very common in human hepatocellular carcinoma, and induction of hepatic p53 expression causes lysis of implanted hepatoblastoma cells in a chimeric mouse." | 1.36 | Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. ( Dan, YY; Farrell, G; Fausto, N; Gu, Y; Hou, J; Mitchell, C; Pyakurel, P; Swisshelm, K; Teoh, N, 2010) |
| "Also, hepatoma cells use PDGFRalpha/PIK3CA signaling as an escape mechanism following beta-catenin suppression, and their sequential suppression profoundly impedes tumor proliferation." | 1.36 | Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. ( Kim, Y; Klaunig, JE; Misse, A; Monga, SP; Singh, S; Tan, X; Zeng, G; Zhang, XF, 2010) |
| "Chromosomal instability is a characteristic feature of hepatocellular carcinoma (HCC) but its origin and role in liver carcinogenesis are undefined." | 1.35 | Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice. ( Dan, YY; Fausto, N; Gu, Y; Haque, J; Lehman, S; Swisshelm, K; Teoh, NC; Wright, JH, 2008) |
| " Simultaneously, hepatocarcinoma were induced in groups II-V by diethylnitrosamine (DEN) solution (100 mg/L) at the dosage of 10 mg/kg body weight every day as drinking water for 16 weeks, then sterilized water for a further two weeks." | 1.35 | Effect of selenium-enriched malt on hypoglycemia and regulatory hormones in diethylnitrosamine-induced hepatocarcinoma SD rats. ( Liu, JG; Liu, YJ; Wang, XL; Zhao, HJ, 2009) |
| "Ursolic acid is a natural triterpenoid widely found in food, medicinal herbs, apple peel and other products it has been extensively studied for its anticancer and antioxidant properties." | 1.35 | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2009) |
| "Cotreatment with morin prevented the elevation of marker enzymes induced by N-nitrosodiethylamine." | 1.35 | Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin. ( Niranjali Devaraj, S; Praveen Kumar, VR; Shilpa, PN; Sivaramakrishnan, V, 2008) |
| "NDEA-induced rats showed severe hyperlipidemia along with upregulated expression of COX-2 as revealed by western blotting and immunohistochemistry." | 1.35 | Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma. ( Anandakumar, P; Augustine, TA; Devaki, T; Elinos-Báez, CM; Jagan, S; Kamaraj, S; Ramakrishnan, G, 2008) |
| "Pioglitazone treatment was initiated the day after the first diethylnitrosamine injection." | 1.34 | The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver. ( Borbath, I; Horsmans, Y; Leclercq, I; Moulin, P; Sempoux, C, 2007) |
| "The number of hepatocellular carcinomas (HCCs) was significantly increased in Tg compared with non-Tg rats." | 1.34 | Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication. ( Asamoto, M; Futakuchi, M; Hokaiwado, N; Ogawa, K; Shirai, T; Takahashi, S, 2007) |
| "Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of beta1-ARs, extensive areas completely devoid of beta1-ARs being mingled with areas showing a weak immunostaining." | 1.33 | Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats. ( Cardani, R; Zavanella, T, 2005) |
| "In murine and human hepatoma cells, IRS-2 protein induction associated with increased IRS-2 mRNA levels." | 1.33 | Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma. ( Beurel, E; Boissan, M; Desbois-Mouthon, C; Housset, C; Lacombe, ML; Lécluse, Y; Rey, C; Wendum, D, 2005) |
| "Incidences of lung metastasis in the 40 ppm group steadily increased up to 67% by week 36 while that in the 80 ppm increased sharply up to 86% by week 24." | 1.33 | Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. ( Cho, YM; Futakuchi, M; Imai, N; Ogawa, K; Shirai, T; Takeshita, F; Tamano, S; Yoshino, H, 2005) |
| "Value of spin states ratio in hepatoma was shown to be greater then in liver." | 1.33 | [Ratio of low- and high-spin cytochrome P-450 in liver microsomes of N-nitrosodiethylamine-induced hepatomas]. ( Mel'nykov, OR; Momot, VIa; P'iatchanina, TV; Sydoryk, IeP, 2005) |
| "As tumors progressed to hepatocellular carcinomas, the additional Tg FoxM1B protein had no effect on cell proliferation, and there was no increase in tumor burden compared to wild-type animals." | 1.32 | Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions. ( Adami, GR; Costa, RH; Kalinin, SA; Kalinina, OA; Mikaelian, I; Panda, S; Polack, EW, 2003) |
| "The question whether hepatocellular carcinoma (HCC) arises from dedifferentiation of mature hepatocytes or from proliferation of liver stem cells is still debated." | 1.31 | Demonstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats. ( Bralet, MP; Ferry, N; Pichard, V, 2002) |
| "Diethylnitrosamine-treated TT mice developed both preneoplastic and neoplastic lesions in the liver." | 1.31 | Enhancement of chemical hepatocarcinogenesis by the HIV-1 tat gene. ( Altavilla, G; Barbanti-Brodano, G; Caputo, A; Corallini, A; Lanfredi, M; Piola, C, 2000) |
| "For better understanding of cancer metastasis, we have established an in vivo model for induction of highly metastatic hepatocellular carcinomas (HCC) in male F344 rats." | 1.31 | Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice. ( Asamoto, M; Futakuchi, M; Imaida, K; Nakanishi, H; Ogawa, K; Shirai, T; Takeshita, F; Tatematsu, M, 2001) |
| "The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0." | 1.31 | Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001) |
| "The incidence of hepatocellular carcinoma (HCC) is more prevalent in males than in females." | 1.31 | Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats. ( Dhar, DK; El-Assal, ON; Maruyama, S; Nagasue, N; Okita, K; Satoh, K; Yamanoi, A, 2001) |
| "In gene therapy for hepatocellular carcinoma (HCC), gene transfer is efficient for small tumors, but not for large tumors." | 1.31 | Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters. ( Eto, Y; Futagawa, Y; Ohashi, T; Okamoto, T; Shiba, H, 2001) |
| "Hepatocellular carcinomas were induced with the decreased Bcl-x protein expression." | 1.31 | Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats. ( Ashida, H; Danno Gi, G; Hashizume, K; Hatanaka, Y; Kamihara, Y; Kinoshita, N; Konishi, Y; Mutai, M; Nakae, D; Ohta, S; Tani, Y, 2001) |
| "Diethylnitrosamine (DEN) was administered at the age of 8 weeks." | 1.30 | Chronic liver injury promotes hepatocarcinogenesis of the LEC rat. ( Enomoto, K; Hattori, A; Mori, M; Sawada, N; Sawaki, M; Sugawara, N; Tsuzuki, N, 1998) |
| "In contrast, five hepatoma cell lines (Fao, Faza, H5, HTC and RHC1) showed either a decrease or an absence of OCT1 expression compared to normal hepatocytes; these hepatoma cells also displayed lower intracellular accumulation of tetraethylammonium (TEA), a well-known substrate for OCT1." | 1.30 | Differential expression of the polyspecific drug transporter OCT1 in rat hepatocarcinoma cells. ( Fardel, O; Guillouzo, A; Lecureur, V, 1998) |
| "The average score of liver cirrhosis associated with HCV was 1." | 1.30 | Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. ( Hino, S; Kamahora, T; Kawasaki, H; Miyata, H; Shimada, A; Shiota, G; Shiraki, K; Terada, T, 1998) |
| "Trichloroethylene (TCE) was found as a contaminant in the well supplying water to an aquatic testing laboratory." | 1.30 | Environmental complex mixture toxicity assessment. ( Boncavage-Hennessey, EM; Brennan, LM; Gardner, HS; Rosencrance, AB; Toussaint, MW; Wolfe, MJ, 1998) |
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 1.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| "Histologically, the tumors were hepatocellular carcinomas (HCCs) of trabecular, (pseudo)glandular and solid types with or without cholangiocellular involvement." | 1.30 | Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine. ( Ahn, B; Han, BS; Kim, DJ; Ohshima, H, 1999) |
| "These results show that rat hepatoma cells can display elevated levels of functional P-glycoprotein without any prior cytotoxic drug selection and suggest that these cells represent a useful model for analyzing P-glycoprotein regulation in intrinsically clinical drug-resistant cancers." | 1.29 | Constitutive expression of functional P-glycoprotein in rat hepatoma cells. ( Fardel, O; Glaise, D; Guillouzo, A; Lecureur, V; Loyer, P, 1994) |
| "HAM-6 was also slightly reactive to rat hepatocellular carcinoma, but not to normal or fetal rat liver, other normal rat organs, human hepatocellular carcinoma, or human liver cirrhosis." | 1.29 | Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens. ( Kurokawa, F, 1994) |
| "These results suggested that LEC rat hepatocellular carcinoma could be naturally initiated after the onset of hepatitis by carcinogens contaminating food and the environment, probably due to the reduction of DNA repair activity, after which initiated hepatocytes selectively proliferate in response to growth stimuli endogenously produced as a result of continuous loss of hepatocytes (chronic hepatitis), because of a decrease in growth activity of non-initiated hepatocytes." | 1.29 | High sensitivity of LEC rats with chronic hepatitis to hepatocarcinogenesis: decreases in unscheduled and replicative DNA synthesis of the hepatocytes. ( Enomoto, K; Kamimura, Y; Mori, M; Sakamoto, H; Sawada, N, 1993) |
| "The gangliosides of human hepatoma biopsies, human hepatoma cell lines, and diethylnitrosamine-induced rat hepatomas were examined." | 1.28 | Enhanced expression of ganglioside GD3 in human and rat hepatocellular carcinoma cells and NIH 3T3 cells transfected with human tumor DNAs. ( Fuhrer, JP; Gao, NH; Gu, JR; Gu, TG; Lee, W; Murphy, MJ; Xia, LA; Ye, JN, 1990) |
| "Histological characterization of hepatocellular carcinoma, hemangiopericytic sarcoma, and cholangiocarcinoma and the development of the neoplasms in host fish is presented." | 1.27 | Transplantable chemically-induced liver tumors in the viviparous fish Poeciliopsis. ( Schultz, ME; Schultz, RJ, 1985) |
| "Diethylnitrosamine (NDEA) was administered subcutaneously to non-icteric and icteric Gunn rats." | 1.27 | The influence of metabolic liver defects on diethylnitrosamine (NDEA)-carcinogenesis in Gunn rats. ( Althoff, J; Fehst, HJ; Mohr, U, 1985) |
| "Transplantable hepatomas varied in their fibronectin staining from fibronectin-negative hepatomas to ones with fibronectin staining within or around every tumor cell." | 1.26 | Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas. ( Ruoslahti, E; Sell, S, 1982) |
| "Methionine was contained in both the amino acid and the lipotrope supplement and probably was responsible for reducing hepatocarcinoma incidence." | 1.26 | Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet. ( Rogers, AE, 1977) |
| " Chronic administration of diethylnitrosamine slightly increased the hepatic methylcobalamin concentration, but this was not statistically significant." | 1.26 | Altered cobalamin distribution in rat hepatomas and in the livers of rats treated with diethylnitrosamine. ( Linnell, JC; Matthews, DM; Morris, HP; Poirier, LA; Quadros, EV, 1977) |
| "induced tumors of liver (hepatocellular cancers and adenomas), and of hematopoietic system (hemocytoblastosis)." | 1.26 | The induction of tumors in Rana temporaria with nitrosamines. ( Khudoley, VV, 1977) |
| " The highest activity was obtained with antisera (Cx-1) produced by repeated intravenous injections of living L-10 cells at high cell dosage, whereas intramuscular injections of living or glutaraldehyde-treated L-10 cells at similar frequency and cell dosage were less effective for the production of cytotoxic antibodies against L-10 cells." | 1.26 | Susceptibility to and escape from complement-mediated lysis of guinea-pig hepatoma line-10. ( Abe, S; Berczi, I; Sehon, AH, 1977) |
| "The pulmonary metastases were first detected in mice dying between 51 and 60 weeks of age (5%)." | 1.26 | Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice. ( Mihailovich, N; Rao, KV; Vesselinovitch, SD, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 64 (9.71) | 18.7374 |
| 1990's | 39 (5.92) | 18.2507 |
| 2000's | 106 (16.08) | 29.6817 |
| 2010's | 338 (51.29) | 24.3611 |
| 2020's | 112 (17.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balaraman, G | 2 |
| Sundaram, J | 2 |
| Mari, A | 2 |
| Krishnan, P | 2 |
| Salam, S | 2 |
| Subramaniam, N | 3 |
| Sirajduddin, I | 1 |
| Thiruvengadam, D | 3 |
| Lu, Y | 5 |
| Pan, J | 4 |
| Zhu, X | 1 |
| Zhang, S | 6 |
| Liu, C | 10 |
| Sun, J | 3 |
| Li, Y | 13 |
| Chen, S | 4 |
| Huang, J | 2 |
| Cao, C | 2 |
| Wang, Y | 12 |
| Liu, T | 3 |
| Mamdouh, AM | 1 |
| Khodeer, DM | 1 |
| Tantawy, MA | 1 |
| Moustafa, YM | 1 |
| Xu, L | 2 |
| Yang, C | 4 |
| Wang, J | 12 |
| Li, Z | 6 |
| Huang, R | 1 |
| Ma, H | 1 |
| Ma, J | 1 |
| Wang, Q | 5 |
| Xiong, X | 1 |
| Chun, HJ | 1 |
| Shim, YJ | 1 |
| Kwon, YH | 2 |
| Fu, H | 1 |
| Liu, X | 4 |
| Jin, L | 1 |
| Lang, J | 1 |
| Hu, Z | 1 |
| Mao, W | 1 |
| Cheng, C | 1 |
| Shou, Q | 1 |
| Badr, AM | 1 |
| El-Ahwany, E | 5 |
| Goda, L | 1 |
| Nagy, F | 1 |
| Helal, N | 1 |
| El Deeb, S | 1 |
| Haberl, EM | 3 |
| Pohl, R | 3 |
| Rein-Fischboeck, L | 3 |
| Höring, M | 2 |
| Krautbauer, S | 3 |
| Liebisch, G | 3 |
| Buechler, C | 3 |
| Sakai, H | 1 |
| Yamada, Y | 3 |
| Kubota, M | 1 |
| Imai, K | 1 |
| Shirakami, Y | 2 |
| Tomita, H | 1 |
| Hara, A | 2 |
| Shimizu, M | 2 |
| Nabeel, AI | 1 |
| Mansour, SZ | 2 |
| Mahdy, EME | 1 |
| El-Mezayen, HA | 3 |
| Mohamed, SA | 1 |
| Ghufran, H | 1 |
| Azam, M | 1 |
| Mehmood, A | 1 |
| Butt, H | 1 |
| Riazuddin, S | 1 |
| Chao, X | 1 |
| Wang, S | 4 |
| Hlobik, M | 1 |
| Ballabio, A | 1 |
| Ni, HM | 1 |
| Ding, WX | 1 |
| Karanam, G | 1 |
| Arumugam, MK | 1 |
| Li, X | 9 |
| Yu, H | 3 |
| Gong, Y | 2 |
| Wu, P | 2 |
| Feng, Q | 1 |
| Vidya, R | 2 |
| Kalaivani, K | 1 |
| Amudha, P | 2 |
| Márquez-Quiroga, LV | 1 |
| Arellanes-Robledo, J | 4 |
| Vásquez-Garzón, VR | 2 |
| Villa-Treviño, S | 5 |
| Muriel, P | 1 |
| Lee, SR | 2 |
| Jeong, SH | 1 |
| Heo, JH | 1 |
| Jo, SL | 1 |
| Ko, JW | 1 |
| Kwun, HJ | 1 |
| Hong, EJ | 2 |
| Li, S | 4 |
| Sun, H | 1 |
| Jiang, Y | 3 |
| Pan, K | 1 |
| Su, Y | 1 |
| Bu, N | 1 |
| Kidoguchi, S | 1 |
| Kitada, K | 1 |
| Nakajima, K | 1 |
| Nakano, D | 1 |
| Ohsaki, H | 1 |
| Kittikulsuth, W | 1 |
| Kobara, H | 1 |
| Masaki, T | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biomarker Analyses in Hepatocellular Carcinoma Patients Treated With Therasphere®[NCT03203837] | 4 participants (Actual) | Observational | 2017-07-05 | Terminated (stopped due to Funding Discontinued due to low accrual rate) | |||
| Phase I-II Study of Intratumoral Urelumab Combined With Nivolumab in Patients With Solid Tumors[NCT03792724] | Phase 1/Phase 2 | 32 participants (Anticipated) | Interventional | 2019-01-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for diethylnitrosamine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Diseas | 2022 |
Diethylnitrosamine-induced liver tumorigenesis in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Liver; Liver Neoplas | 2021 |
Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Hepa | 2016 |
Immunotherapy of hepatocellular carcinoma: is there a place for regulatory T-lymphocyte depletion?
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellular; Diethylnitrosamine; | 2011 |
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; G | 2002 |
The quantitation of altered hepatic foci during multistage hepatocarcinogenesis in the rat: transforming growth factor alpha expression as a marker for the stage of progression.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Count; Cell Transformation, Neoplastic; | 1995 |
Experimental carcinogenesis in small aquarium fishes.
Topics: 2-Acetylaminofluorene; Adenoma; Adenoma, Bile Duct; Aflatoxins; Animals; Benzopyrenes; Carcinogens; | 1976 |
Diethylnitrosamine-induced hepatocarcinogenesis in rats: a theoretical study.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Li | 1991 |
1 trial available for diethylnitrosamine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Carbon Tetrachloride; Carcinoma, Hepa | 2013 |
650 other studies available for diethylnitrosamine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Farnesol; Inflammation; Liver; | 2021 |
Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Area Under Curve; Carcinoma, Hepatocellular; Diethylnitrosamin | 2021 |
In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma.
Topics: alpha-Fetoproteins; Amygdalin; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogen | 2021 |
Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diet, High-Fat; Diethylni | 2021 |
Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet.
Topics: Amino Acids; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cholesterol; Cholesterol, Dietary; | 2022 |
Safflower yellow reduces DEN-induced hepatocellular carcinoma by enhancing liver immune infiltration through promotion of collagen degradation and modulation of gut microbiota.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chalcone; Collagen; Diethylnitrosamine; Gastro | 2021 |
MicroRNA-26a systemic administration attenuates tumor formation in hepatocellular carcinoma mouse model.
Topics: Alkylating Agents; alpha-Fetoproteins; Animals; Apoptosis; Biomarkers; Carcinoma, Hepatocellular; Ca | 2021 |
Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice.
Topics: Animals; Carcinoma, Hepatocellular; Ceramides; Cholesterol; Diethylnitrosamine; Disease Models, Anim | 2021 |
The phosphorylated retinoid X receptor-α promotes diethylnitrosamine-induced hepatocarcinogenesis in mice through the activation of β-catenin signaling pathway.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Doxycycline; L | 2022 |
In vivo Study of a Newly Synthesized Chromen-4-one Derivative as an Antitumor Agent against HCC.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; bcl-2-Associated X Protein; | 2022 |
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamin | 2021 |
Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Topics: Alcohol Drinking; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinogenes | 2022 |
Potential anticancer effects of cyclo(-Pro-Tyr) against N-diethyl nitrosamine induced hepatocellular carcinoma in mouse through PI3K/AKT signaling.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Dipeptides; Liver Neoplasms; Male | 2022 |
Fuzheng Xiaozheng prescription relieves rat hepatocellular carcinoma through improving anti-inflammation capacity and regulating lipid related metabolisms.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Drugs, Chinese Herbal | 2022 |
Therapeutic Potential of Cucumis melo (L.) Fruit Extract and Its Silver Nanopartciles Against DEN-Induced Hepatocellular Cancer in Rats.
Topics: Animals; Carcinoma, Hepatocellular; Cucumis melo; Diethylnitrosamine; Fruit; Liver Neoplasms, Experi | 2022 |
Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin.
Topics: Androgens; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Disease P | 2021 |
Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; Fruit; Gene Ex | 2021 |
Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats.
Topics: Aldosterone; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms, Experimental; | 2022 |
Evaluation of anti-cancer effect of zerumbone and cisplatin on
Topics: Animals; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Fresh Water; Humans; Liver Neopla | 2022 |
Anti-hepatocellular carcinoma efficacy of Fuzheng Xiaozheng prescription and its interventional mechanism studies.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Resp | 2022 |
Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chromatography, Liquid; Cytoc | 2022 |
1H-NMR-based metabolomics reveals the biomarker panel and molecular mechanism of hepatocellular carcinoma progression.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Male; Me | 2022 |
New Approach about the Signaling Crosstalk between IQGAPs/ NF- κB/IL-8 and PDCD5/p53/TRAIL Pathways that Modulate Malignant Transformation in Hepatocellular Carcinoma.
Topics: Animals; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2022 |
Comparative subcellular localization of NRF2 and KEAP1 during the hepatocellular carcinoma development in vivo.
Topics: Actin Cytoskeleton; Animals; Carcinoma, Hepatocellular; Cell Nucleus; Cyclooxygenase 1; Diethylnitro | 2022 |
Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats.
Topics: Animals; Antioxidants; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Lipids; Liver; Li | 2023 |
Dual regulating of mitochondrial fusion and Timp-3 by leflunomide and diallyl disulfide combination suppresses diethylnitrosamine-induced hepatocellular tumorigenesis in rats.
Topics: Alkylating Agents; Allyl Compounds; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Dieth | 2022 |
Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats.
Topics: Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Isofla | 2022 |
Anticancer Effect of Arbutin on Diethylnitrosamine-Induced Liver Carcinoma in Rats via the GRP and GADD Pathway.
Topics: Animals; Arbutin; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Rats | 2022 |
Suppressive effects of thymoquinone on the initiation stage of diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Antioxidants; Benzoquinones; Carcinoma, Hepatocellular; Diethylnitrosamine; Glutathione; Li | 2022 |
Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model.
Topics: Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Feasibility Studies; Liver N | 2023 |
Topics: Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; ErbB Receptors; Gamma Rays; Liver; Liver N | 2023 |
Boron attenuated diethylnitrosamine induced hepatocellular carcinoma in C3H/HeN mice via alteration of oxidative stress and apoptotic pathway.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Boron; Carcinoma, Hepatocellular; Casp | 2022 |
Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Bilirubin; Body Weight; Carcinoma, Hepatocellular; Diethy | 2022 |
Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma.
Topics: alpha-Fetoproteins; Animals; Body Weight; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; | 2022 |
MitoQ demonstrates connexin- and p53-mediated cancer chemoprevention in N-nitrosodiethylamine-induced hepatocarcinogenesis rodent model.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Chemoprevention; Connexins; Diethylnitrosamine; | 2022 |
MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Fatt | 2022 |
Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3-mediated cancer development.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Humans; | 2022 |
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib | 2022 |
Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study.
Topics: Animals; beta Catenin; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; Fibrosis; Gold; Int | 2023 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Diethylnitrosamine; Liver Neoplasms; Mal | 2022 |
Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Liver Neoplasms; NF | 2022 |
Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Liver Neoplasms; NF | 2022 |
Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Liver Neoplasms; NF | 2022 |
Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Liver Neoplasms; NF | 2022 |
SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Liver Neoplasms; Mice; M | 2023 |
SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Liver Neoplasms; Mice; M | 2023 |
SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Liver Neoplasms; Mice; M | 2023 |
SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Liver Neoplasms; Mice; M | 2023 |
Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; Diet, High-Fat; Diethylnitrosamine; Diseas | 2023 |
Potential of siRNA-Bearing Subtilosomes in the Treatment of Diethylnitrosamine-Induced Hepatocellular Carcinoma.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; | 2023 |
Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; L | 2023 |
Intestinal microecology in mice bearing diethylnitrosamine-induced primary hepatocellular carcinoma.
Topics: Animals; Bacteria; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, | 2022 |
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Humans; Li | 2023 |
Lactosylated Chitosan Nanoparticles Potentiate the Anticancer Effects of Telmisartan In Vitro and in a
Topics: Animals; Carcinoma, Hepatocellular; Chitosan; Diethylnitrosamine; Hep G2 Cells; Humans; Liver Neopla | 2023 |
Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Estrogens; Fatty Acid Synthases; Female; Int | 2023 |
The essential role of O-GlcNAcylation in hepatic differentiation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Differentiation; Diethylnitrosamine; Fibrosis; Humans; Live | 2023 |
Hepatoprotective effects of aspirin on diethylnitrosamine-induced hepatocellular carcinoma in rats by reducing inflammation levels and PD-L1 expression.
Topics: Animals; Aspirin; B7-H1 Antigen; Carcinoma, Hepatocellular; Diethylnitrosamine; Inflammation; Liver | 2023 |
Whole transcriptome analysis of chemically induced hepatocellular carcinoma using RNA-sequencing analysis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Profiling; Gene Expression R | 2019 |
Hepatoprotective effect of boldine against diethylnitrosamine-induced hepatocarcinogenesis in wistar rats.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Apoptosis; Aporphines; bcl-2-Associated X Protein; Carcin | 2019 |
Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; | 2019 |
A novel chemoprotective effect of tiopronin against diethylnitrosamine-induced hepatocellular carcinoma in rats: Role of ASK1/P38 MAPK-P53 signalling cascade.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Li | 2020 |
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diet | 2019 |
Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice.
Topics: Animals; Artemisia; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; | 2020 |
Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carcinogenesis; Carcinoma, Hepatocellu | 2020 |
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
Topics: Aldehyde Dehydrogenase; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; delt | 2020 |
Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Inflammation; Liver; | 2020 |
Effects of Medium-chain Triglycerides Administration in Chemically-induced Carcinogenesis in Mice.
Topics: 3-Hydroxybutyric Acid; Adipocytes; Adipokines; Adiponectin; Adipose Tissue; Aldehydes; Animal Feed; | 2019 |
Extracellular ATP and Purinergic P2Y
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; C | 2020 |
Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cyclin D1; Diethyln | 2019 |
Overexpression of Hepatocyte Chemerin-156 Lowers Tumor Burden in a Murine Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Chemokines; Cholesterol; Diethylnitrosamine; Diglycerides; Disea | 2019 |
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced | 2020 |
Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 2; Diethyln | 2020 |
Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosa | 2020 |
Combretastatin A-4 disodium phosphate and low dose gamma irradiation suppress hepatocellular carcinoma by downregulating ROCK1 and VEGF gene expression.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chemoradiotherapy; Combined M | 2020 |
Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Caseins; Diet, Vegetarian; Diethylnitrosamine; F | 2020 |
Administration of Steamed and Freeze-Dried Mature Silkworm Larval Powder Prevents Hepatic Fibrosis and Hepatocellular Carcinogenesis by Blocking TGF-β/STAT3 Signaling Cascades in Rats.
Topics: Animals; Bombyx; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; | 2020 |
MicroRNA-195 vector influence on the development of gradually induced hepatocellular carcinoma in murine model.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Liver N | 2020 |
Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; Catechin; Cellular Senescen | 2020 |
The potential chemotherapeutic effect of β-ionone and/or sorafenib against hepatocellular carcinoma via its antioxidant effect, PPAR-γ, FOXO-1, Ki-67, Bax, and Bcl-2 signaling pathways.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Ce | 2020 |
Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma.
Topics: Aminocoumarins; Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Death; | 2020 |
The role of bone marrow-derived cells in the origin of liver cancer revealed by single-cell sequencing.
Topics: Animals; Biomarkers, Tumor; Bone Marrow Cells; Bone Marrow Transplantation; Carcinoma, Hepatocellula | 2020 |
Citral inhibits N-nitrosodiethylamine-induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic-metabolizing enzymes.
Topics: Acyclic Monoterpenes; alpha-Fetoproteins; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; | 2020 |
Investigation of the Effects of Octreotide Agent on Oxidative Stress, 8-Hydroxy Deoxyguanosine in Experimental Hepatic Carcinogenesis Rat Model.
Topics: 2-Acetylaminofluorene; 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Hormonal; Carcin | 2020 |
Differential changes in the pharmacokinetics of doxorubicin in diethylnitrosamine-induced hepatocarcinoma model rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Doxorubicin; Liver Neoplasms; Rats | 2020 |
Establishment of rat liver cancer cell lines with different metastatic potential.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Disease Models, Animal; Ka | 2020 |
Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Hepatocellular; CRISPR-Cas Systems; D | 2020 |
Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Calcium Channel Blockers; Carcinoma, Hepatocellular | 2020 |
STAT3 and AKT signaling pathways mediate oncogenic role of NRSF in hepatocellular carcinoma.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethylnitros | 2020 |
Time serial transcriptome reveals
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cytochrome P450 Family 2; | 2020 |
Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Animals; Carcinoma, Hepatocellular; Coenzyme A Ligases; Diet, | 2020 |
Vicenin-2 Treatment Attenuated the Diethylnitrosamine-Induced Liver Carcinoma and Oxidative Stress through Increased Apoptotic Protein Expression in Experimental Rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apigenin; Apo | 2020 |
A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2020 |
Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Diethyln | 2020 |
Three-Dimensional Augmented Reality Visualization Informs Locoregional Therapy in a Translational Model of Hepatocellular Carcinoma.
Topics: Acrylic Resins; Animals; Augmented Reality; Carcinoma, Hepatocellular; Diethylnitrosamine; Embolizat | 2020 |
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.
Topics: Adult; Aged; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferatio | 2021 |
Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance.
Topics: Animals; Antineoplastic Agents; Cancer-Associated Fibroblasts; Carcinoma, Hepatocellular; Coculture | 2021 |
Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Diethylnitr | 2021 |
Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Catechin; cdc25 Phosphatases; | 2020 |
Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats.
Topics: Animals; Annona; Antineoplastic Agents, Phytogenic; Antioxidants; Carbon Tetrachloride; Carcinoma, H | 2020 |
Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosa | 2021 |
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Def | 2020 |
Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Inflammation; Limonins; Live | 2020 |
Romidepsin hepatocellular carcinoma suppression in mice is associated with deregulated gene expression of bone morphogenetic protein and Notch signaling pathway components.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Carcinoma, Hepatocellular; Cell | 2021 |
Inhibitory and ameliorative effect of heliomycin derived from actinomycete on induced hepatocellular carcinoma in rats.
Topics: Actinobacteria; Alanine Transaminase; alpha-Fetoproteins; Animals; Anticarcinogenic Agents; Aspartat | 2021 |
Dietary modulations of folic acid affect the development of diethylnitrosamine induced hepatocellular carcinoma in a rat model.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Folic Acid; Liver; Liver Cirrhosis; Liver Ne | 2021 |
Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosa | 2021 |
Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; | 2021 |
Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks.
Topics: Androgens; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; | 2021 |
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model.
Topics: Activity Cycles; Animals; Behavior, Animal; Biomarkers; Carcinoma, Hepatocellular; Chronotherapy; Ci | 2021 |
Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carcinoma, Hepa | 2021 |
Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline Deficiency; Cyclin-De | 2021 |
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocel | 2021 |
Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethyln | 2021 |
Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinoma, Hepatocellular; Diethylnitro | 2021 |
Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Shape; Chemical and Drug Induced Liver | 2021 |
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Animals; Arginine; Carcinogenesis; Carcinoma, Hep | 2021 |
Therapeutic Role of Bone Marrow-Derived Mesenchymal Stem Cells in Controlling Prognosis of Hepatocellular Carcinoma in a Murine Model.
Topics: Animals; Bone Marrow; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Humans; | 2022 |
Periostin deficiency reduces diethylnitrosamine-induced liver cancer in mice by decreasing hepatic stellate cell activation and cancer cell proliferation.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Proliferation; Diethy | 2021 |
The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; Din | 2022 |
Chemopreventive Effect of
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Clusiaceae | 2021 |
The Therapeutic Effect of Myrrh (Commiphora molmol) and Doxorubicin on Diethylnitrosamine Induced Hepatocarcinogenesis in Male Albino Rats.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Carcinoma, Hepatocellular; Commiphora; Diethylnitrosamine; | 2021 |
Ameliorative potential of manganese nanoparticles with low-level ionizing radiation against experimentally induced hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gamma Rays; Liver; Liver Neoplasms, Experime | 2021 |
Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression.
Topics: Albendazole; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Biological Availability; Carci | 2021 |
Vidatox 30 CH has tumor activating effect in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line; Cell Line | 2017 |
The chemo-prophylactic efficacy of an ethanol Moringa oleifera leaf extract against hepatocellular carcinoma in rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers | 2017 |
Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cholesterol; Diethylnitrosamine | 2017 |
CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression.
Topics: Animals; Aurora Kinase B; Biological Transport; Carcinogens; Carcinoma, Hepatocellular; Cell Nucleus | 2018 |
In vivo antitumour potential of camel's milk against hepatocellular carcinoma in rats and its improvement of cisplatin renal side effects.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Camelus; Carcinoma, Hepatocellular; Cisplatin; Dieth | 2017 |
Deriving and testing of dysplastic murine hepatocytes: A new platform in liver cancer research.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Cell Transformation, | 2017 |
Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Emboliz | 2017 |
Time-caloric restriction inhibits the neoplastic transformation of cirrhotic liver in rats treated with diethylnitrosamine.
Topics: Animals; Caloric Restriction; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, Neopla | 2017 |
Tg737 regulates epithelial-mesenchymal transition and cancer stem cell properties via a negative feedback circuit between Snail and HNF4α during liver stem cell malignant transformation.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Cell Transformation, N | 2017 |
Chronic Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis via Immune Disturbances.
Topics: Alcohol Drinking; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Pr | 2017 |
Chitosan nanoparticles from marine squid protect liver cells against N-diethylnitrosoamine-induced hepatocellular carcinoma.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Chitosan; Decapodiformes; Diethylnitrosamine; Lipi | 2017 |
Triterpenoids principle of Wedelia calendulacea attenuated diethynitrosamine-induced hepatocellular carcinoma via down-regulating oxidative stress, inflammation and pathology via NF-kB pathway.
Topics: Animals; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Diethylnit | 2018 |
Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study.
Topics: alpha-Fetoproteins; Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosa | 2017 |
MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholesterol; Diethylnitrosamine; Down-Regulati | 2017 |
Role of insulin receptor substrates in the progression of hepatocellular carcinoma.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progre | 2017 |
An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease M | 2018 |
Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation, Ne | 2017 |
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Topics: ADAM17 Protein; Albumins; Animals; ATP Binding Cassette Transporter, Subfamily B; Carcinogenesis; Ca | 2017 |
Umbelliferon-α-d-glucopyranosyl-(2
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Proliferation; Cytok | 2017 |
Nelumbo nucifera leaf extract treatment attenuated preneoplastic lesions and oxidative stress in the livers of diethylnitrosamine-treated rats.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Aspartate Aminotrans | 2017 |
Gamma-irradiated β-glucan modulates signaling molecular targets of hepatocellular carcinoma in rats.
Topics: Animals; beta-Glucans; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gamma | 2017 |
Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosami | 2017 |
Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Blotting, Western; Carcinoma, Hepatocellul | 2017 |
Sequential analysis and staging of a diethylnitrosamine-induced hepatocellular carcinoma in male Wistar albino rat model.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Lipids; | 2017 |
Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Apolipoprotein A-I; Biomarkers, Tumor; Carcinom | 2018 |
In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biomarkers, Tumor; Body Weight; Carcinoma, Hepatocellu | 2017 |
Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; | 2017 |
Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclin D1; Diethylnitrosamine; | 2017 |
Voluntary Wheel Running Reduces the Acute Inflammatory Response to Liver Carcinogen in a Sex-specific Manner.
Topics: Acute Disease; Animals; Carcinogens; Carcinoma, Hepatocellular; Choice Behavior; Diethylnitrosamine; | 2017 |
Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB pathway in mice.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Deoxyadenosines; Diethylnitrosamine; Do | 2017 |
Identification of (Z)-2,3-Diphenylacrylonitrileas Anti-Cancer Molecule in Persian Gulf Sea Cucumber Holothuria parva.
Topics: 2-Acetylaminofluorene; Acrylonitrile; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chr | 2017 |
Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; | 2018 |
Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Administration, Intravenous; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Pro | 2017 |
Anticancer potential of ZnO nanoparticle-ferulic acid conjugate on Huh-7 and HepG2 cells and diethyl nitrosamine induced hepatocellular cancer on Wistar albino rat.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Prolif | 2018 |
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Gen | 2017 |
Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma.
Topics: Animals; Arginase; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Diethylnitrosamine; Fema | 2018 |
The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepato | 2018 |
Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 | 2018 |
Effect of diosmin on apoptotic signaling molecules in N-nitrosodiethylamine-induced hepatocellular carcinoma in experimental rats.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Diosmin; Liver Neoplasms, Experim | 2018 |
In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver; Li | 2018 |
Ellagic Acid Holds Promise Against Hepatocellular Carcinoma\
in an Experimental Model: Mechanisms of Action
Topics: Alkylating Agents; alpha-Fetoproteins; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cells, | 2018 |
Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytokines; Diet, High-Fat; Diethylnitrosamin | 2018 |
Hepatocyte Wnts Are Dispensable During Diethylnitrosamine and Carbon Tetrachloride-Induced Injury and Hepatocellular Cancer.
Topics: Animals; beta Catenin; Cadherins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamin | 2018 |
β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin.
Topics: AC133 Antigen; Animals; beta Catenin; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tu | 2018 |
Therapeutic role of calcium and vitamin K3 in chemically induced hepatocarcinogenesis - new tools for cancer treatment.
Topics: Alkylating Agents; Animals; Biomarkers; Calcium; Carcinoma, Hepatocellular; Caspase 3; Diethylnitros | 2019 |
The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
Topics: Aged; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cohort St | 2019 |
Impact of Mesenchymal Stem Cells and Vitamin D on Transforming Growth Factor Beta Signaling Pathway in Hepatocellular Carcinoma in Rats
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cells, Cultured; Diethylnitrosamine; Female; | 2018 |
WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diet, High-Fat; Diethylnit | 2018 |
HCC Specific Protein Network Involving Interactions of EGFR with A-Raf and Transthyretin: Experimental Analysis and Computational Biology Correlates.
Topics: Animals; Carcinoma, Hepatocellular; Computational Biology; Diethylnitrosamine; Dose-Response Relatio | 2018 |
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
Topics: Animals; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholangiocarcinoma; Chole | 2018 |
Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosam | 2018 |
Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death, compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activation.
Topics: Animals; Carcinoma, Hepatocellular; Caspase 3; Cell Death; Cell Proliferation; Cell Transformation, | 2018 |
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosa | 2018 |
Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Circadian Clocks; Diethylnitrosamine; Endoplas | 2018 |
Resistive Part of Impedance as a Possible Indicator of Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Electric Impedance; Liver; Liver Neoplasms; | 2018 |
Inhibitory effects of mushroom extracts on progression of carcinogenesis in mice.
Topics: Agaricus; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transfo | 2018 |
Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Me | 2018 |
Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antineop | 2018 |
Correlation between HSD17B4 expression in rat liver cancer tissues and inflammation or proliferation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Estradiol; Extracellular | 2018 |
From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor.
Topics: Adult; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Diethylnitrosami | 2018 |
Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diet, | 2018 |
FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice.
Topics: Animals; Carcinoma, Hepatocellular; Caspase 1; Diethylnitrosamine; Hepatocytes; Humans; Inflammasome | 2019 |
Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell | 2019 |
Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Move | 2018 |
Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Susceptibility | 2018 |
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an | 2019 |
Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice.
Topics: Age of Onset; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Female; Hi | 2018 |
Elevated Expression of A-Raf and FA2H in Hepatocellular Carcinoma is Associated with Lipid Metabolism Dysregulation and Cancer Progression.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Lipid Metabolism; Liver Neoplasms; M | 2019 |
The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransfera | 2018 |
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High- | 2019 |
Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression via miR-145/miR-21 mediated Smad3 phosphorylation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Astragalus Plant; Carcinoma, Hepatocellular; Diethylnitr | 2019 |
Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes.
Topics: Animals; beta-Carotene 15,15'-Monooxygenase; Carcinoma, Hepatocellular; Carotenoids; Diet, High-Fat; | 2018 |
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcino | 2018 |
Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation
Topics: Animals; Biological Availability; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Compounding; F | 2018 |
Dextrose modified bilosomes for peroral delivery: improved therapeutic potential and stability of silymarin in diethylnitrosamine-induced hepatic carcinoma in rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Survival; Diet | 2019 |
The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways.
Topics: Adult; Aged; Aged, 80 and over; Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Di | 2018 |
Gamma linolenic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced hepatocellular carcinoma.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins | 2018 |
WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Chromosom | 2019 |
Antithrombin Insufficiency Promotes Susceptibility to Liver Tumorigenesis.
Topics: Animals; Antithrombin III; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Fema | 2019 |
Identification of the Potential Metabolic Pathways Involved in the Hepatic Tumorigenesis of Rat Diethylnitrosamine-Induced Hepatocellular Carcinoma via
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose; Glutamic Acid; Glut | 2019 |
Extracts of Qizhu decoction inhibit hepatitis and hepatocellular carcinoma in vitro and in C57BL/6 mice by suppressing NF-κB signaling.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herba | 2019 |
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Pro | 2019 |
Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; | 2019 |
Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; Disease Models, A | 2019 |
Functional characterization of anti-cancer sphingolipids from the marine crab Dromia dehanni.
Topics: Animals; Antineoplastic Agents; Brachyura; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnit | 2019 |
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Topics: alpha-Fetoproteins; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2019 |
Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice.
Topics: Alkylating Agents; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Cyclic N-Oxides | 2019 |
Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (
Topics: Animals; Antioxidants; Biomarkers; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytotoxins; Diethyln | 2019 |
NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Mod | 2019 |
Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 2019 |
Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Carcinoma, Hepatocellular; Diabetes Mellitus, Experimen | 2019 |
Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2019 |
Sex hormone-binding globulin suppresses NAFLD-triggered hepatocarcinogenesis after menopause.
Topics: Acetyl-CoA Carboxylase; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diet, High-Fat; Diethyln | 2019 |
Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Drug Syn | 2019 |
B-mode ultrasound for the assessment of hepatic fibrosis: a quantitative multiparametric analysis for a radiomics approach.
Topics: Animals; Biopsy; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatic Veins; Humans; | 2019 |
Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study.
Topics: Acute-Phase Proteins; Adolescent; Adult; Aged; Animals; Biomarkers; Blood Proteins; Carcinogens; Car | 2019 |
GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; Down-R | 2019 |
Dual-Targeted Lactoferrin Shell-Oily Core Nanocapsules for Synergistic Targeted/Herbal Therapy of Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disaccharides; Drug Delivery Systems; Gene E | 2019 |
Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Progression; Fatty L | 2019 |
An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Contro | 2019 |
Telmisartan attenuates N-nitrosodiethylamine-induced hepatocellular carcinoma in mice by modulating the NF-κB-TAK1-ERK1/2 axis in the context of PPARγ agonistic activity.
Topics: Animals; Antihypertensive Agents; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferati | 2019 |
Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats.
Topics: Animals; Antioxidants; Autophagy; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation | 2013 |
Anticancer effect of ursolic acid stearoyl glucoside in chemically induced hepatocellular carcinoma.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Antineoplastic Agents, Phyt | 2013 |
Protective effects of Scutellaria barbata against rat liver tumorigenesis.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-L-Fucosidase; Animals; Aspartate Aminotransferases | 2013 |
Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicates SEC63 as potential target gene in hepatocarcinogenesis.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Animals; Apoptosis; Carcinoma, Hepa | 2013 |
Cyclin E facilitates dysplastic hepatocytes to bypass G1/S checkpoint in hepatocarcinogenesis.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neoplastic; | 2013 |
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.
Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; | 2013 |
Promyelocytic leukaemia protein links DNA damage response and repair to hepatitis B virus-related hepatocarcinogenesis.
Topics: Adiposity; Animals; Antibiotics, Antineoplastic; Biomarkers; Biopsy; Carcinoma, Hepatocellular; Cell | 2013 |
Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Cell Cycle Proteins; C | 2013 |
Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.
Topics: 5-Methylcytosine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosine; | 2013 |
Mitochondria protection with ginkgolide B-loaded polymeric nanocapsules prevents diethylnitrosamine-induced hepatocarcinoma in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Ginkgolides; Lacton | 2014 |
Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethy | 2013 |
Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells.
Topics: Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chemok | 2013 |
Real-time diagnosis of chemically induced hepatocellular carcinoma using a novel mass spectrometry-based technique.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Liver Neoplasms; Male; Mice; Mice, I | 2013 |
Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53.
Topics: Animals; Biopsy; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Etoposide; G | 2014 |
Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.
Topics: 2-Aminopurine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; | 2013 |
Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Berberine; Blotting, Western; Carbon T | 2014 |
Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP1A1; Depression, Chemica | 2013 |
Anticancer potential of rhamnocitrin 4'-β-D-galactopyranoside against N-diethylnitrosamine-induced hepatocellular carcinoma in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Aspartate Aminotransferases | 2013 |
Two-stage model of chemically induced hepatocellular carcinoma in mouse.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferat | 2013 |
Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Carotenoids; Ce | 2013 |
Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse.
Topics: Acetylcysteine; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line; Diethyl | 2013 |
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepa | 2013 |
Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure.
Topics: Alkylating Agents; Animals; Axl Receptor Tyrosine Kinase; Carcinoma, Hepatocellular; cdc25 Phosphata | 2013 |
Branched-chain amino acids ameliorate fibrosis and suppress tumor growth in a rat model of hepatocellular carcinoma with liver cirrhosis.
Topics: Administration, Oral; Amino Acids, Branched-Chain; Animals; Anticarcinogenic Agents; Carcinogenesis; | 2013 |
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas | 2014 |
Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription.
Topics: Animals; Astragalus Plant; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation | 2014 |
Lipid droplet binding thalidomide analogs activate endoplasmic reticulum stress and suppress hepatocellular carcinoma in a chemically induced transgenic mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Pro | 2013 |
Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antineoplastic Agents; Antirheumatic Agents; Carc | 2014 |
Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis.
Topics: Animals; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinoma, | 2014 |
Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; L | 2013 |
Compound Astragalus and Salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-β/Smad signaling.
Topics: Animals; Astragalus Plant; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship | 2014 |
Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-β1-Smad4-PAI-1 axis.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neoplastic; | 2014 |
CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model.
Topics: Active Transport, Cell Nucleus; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Nucleus; Di | 2013 |
Decorin deficiency promotes hepatic carcinogenesis.
Topics: Animals; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Cyclin-Dependent Kinase Inhib | 2014 |
Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cellular Microenvir | 2014 |
Viral-human chimeric transcript predisposes risk to liver cancer development and progression.
Topics: Animals; Base Sequence; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Di | 2014 |
Possible role of selective, irreversible, proteasome inhibitor (carfilzomib) in the treatment of rat hepatocellular carcinoma.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Endostatins; | 2014 |
High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Dietary Carbohydrates; Dietary Fats; Die | 2014 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul | 2014 |
Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice.
Topics: Alcoholic Beverages; Animals; Carcinoma, Hepatocellular; China; Diethylnitrosamine; Disease Models, | 2014 |
Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease M | 2014 |
Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carcinogenesis; Ca | 2014 |
Cytokeratin 7/19 expression in N-diethylnitrosamine-induced mouse hepatocellular lesions: implications for histogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regu | 2014 |
Apoptotic effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Fragme | 2014 |
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cell T | 2014 |
Androgen receptor enhances cell adhesion and decreases cell migration via modulating β1-integrin-AKT signaling in hepatocellular carcinoma cells.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Dieth | 2014 |
Formylchromone exhibits salubrious effects against nitrosodiethylamine mediated early hepatocellular carcinogenesis in rats.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Ch | 2014 |
Dynamic analysis of tumor-associated immune cells in DEN-induced rat hepatocellular carcinoma.
Topics: Animals; B-Lymphocytes, Regulatory; Bone Marrow Cells; Carcinogens; Carcinoma, Hepatocellular; Cells | 2014 |
Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats.
Topics: Aldehyde Reductase; Alkylating Agents; Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers; Carc | 2014 |
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Diethylnitrosamine; ErbB Rec | 2014 |
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv | 2014 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Curative effect of Amorphophallus campanulatus (Roxb.) Blume. tuber on N-nitrosodiethylamine- induced hepatocellular carcinoma in rats.
Topics: Amorphophallus; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Dieth | 2014 |
Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis.
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Cattle; CCAAT-Binding Factor; | 2015 |
Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Binding Sites; Carcinoma, Hepatocellular; Cell Pr | 2014 |
Evaluation of diethylnitrosamine- or hepatitis B virus X gene-induced hepatocellular carcinoma with 18F-FDG PET/CT: a preclinical study.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Fluorodeoxyglucose F18; Glucose Tran | 2015 |
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2014 |
High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diet, High-Fat; Diet | 2014 |
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Basigin; Carcinogens; Carcinoma, H | 2015 |
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Damage; Gene Expression Regulation, Neop | 2014 |
Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model.
Topics: Alkylating Agents; Animals; beta Catenin; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellul | 2015 |
Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitr | 2015 |
Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis.
Topics: Animals; Antigens, Helminth; Carcinoma, Hepatocellular; Cells, Cultured; Diethylcarbamazine; Diethyl | 2015 |
The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine | 2014 |
C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis.
Topics: Amino Acid Sequence; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitro | 2015 |
MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Flavonoi | 2015 |
Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progression; Endocannabinoids; Forkh | 2015 |
The important role of ADAM8 in the progression of hepatocellular carcinoma induced by diethylnitrosamine in mice.
Topics: ADAM Proteins; Alanine Transaminase; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Antigens, | 2015 |
Mouse models of liver cancer.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Hepatoprotective effects of curcumin against diethyl nitrosamine induced hepatotoxicity in albino rats.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Carcinoma, Hepatocellular; Catalase; Chemical and Drug In | 2015 |
Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regu | 2015 |
Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model.
Topics: Animals; Carcinoma, Hepatocellular; Cytokine Receptor gp130; Diethylnitrosamine; DNA Damage; Female; | 2015 |
Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chromatography, Liquid; Diethylnitrosamine; D | 2015 |
Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumo | 2015 |
Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1 channels as potential early-stage markers of HCC.
Topics: Animals; Apoptosis; Astemizole; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; Di | 2015 |
TGF-β regulates hepatocellular carcinoma progression by inducing Treg cell polarization.
Topics: Animals; Azabicyclo Compounds; Carcinoma, Hepatocellular; Cell Differentiation; Cell Polarity; Cell | 2015 |
NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Calgranulin A; Calgranulin B; Carcinoma, Hepatocellular; Chemokine CXCL1 | 2015 |
Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-β/Smad signaling in hepatocellular carcinoma by multi-target mechanism.
Topics: Alkenes; Animals; Astragalus propinquus; Carcinoma, Hepatocellular; Diethylnitrosamine; Down-Regulat | 2015 |
Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice.
Topics: Animals; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolif | 2015 |
The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cysteine-R | 2016 |
Significance of Rumex vesicarius as anticancer remedy against hepatocellular carcinoma: a proposal-based on experimental animal studies.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; alpha-L-Fucosidase; Animals; Antineo | 2015 |
Insights into glycan biosynthesis in chemically-induced hepatocellular carcinoma in rats: A glycomic analysis.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Computational Biology; Diethylnitrosamine; Gl | 2015 |
Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate.
Topics: Animals; Carcinoma, Hepatocellular; Catechin; Cell Membrane Permeability; Copper; Diethylnitrosamine | 2015 |
β-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling.
Topics: Alkylating Agents; Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Blotting, W | 2015 |
Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.
Topics: Aging; Amino Acid Sequence; Animals; Animals, Genetically Modified; Carcinogenesis; Carcinoma, Hepat | 2015 |
Chemoprevention of Diethylnitrosamine-Initiated and Phenobarbital-Promoted Hepatocarcinogenesis in Rats by Sulfated Polysaccharides and Aqueous Extract of Ulva lactuca.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethyln | 2015 |
Implications of Sex Hormone Receptor Gene Expression in the Predominance of Hepatocellular Carcinoma in Males: Role of Natural Products.
Topics: Animals; Biological Products; Carcinoma, Hepatocellular; Curcumin; Cymenes; Diethylnitrosamine; Down | 2015 |
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chemical and | 2015 |
Protective Effects of Total Glucosides of Paeony on N-nitrosodiethylamine-induced Hepatocellular Carcinoma in Rats via Down-regulation of Regulatory B Cells.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antineoplastic Agents, Phytogenic; Aspartate Am | 2015 |
p53-p66(shc)/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Carbon Tetrachloride; Carcinoma, Hepatoc | 2015 |
Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.
Topics: Animals; Apoptosis Regulatory Proteins; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamin | 2015 |
MiR-17-92 cluster promotes hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease | 2015 |
Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzodioxoles; Carcin | 2015 |
Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodioxoles; Carcinoma, Hepatocellular; Cell Cycle Chec | 2015 |
Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Feasibility Studies; Fluorodeoxyglucose F18; | 2015 |
Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Proliferation; Cell Shape; Cell Transformatio | 2015 |
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Escherichia | 2015 |
Interleukin-17A Plays a Pivotal Role in Chemically Induced Hepatocellular Carcinoma in Mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Deoxyguanosine; | 2016 |
Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients.
Topics: alpha-Fetoproteins; Animals; Betaine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cohort Studies; | 2015 |
Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats.
Topics: Adenylate Kinase; Animals; Blotting, Western; Body Weight; Carcinogenesis; Carcinoma, Hepatocellular | 2016 |
Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; DNA-Binding Prote | 2015 |
Testosterone regulation of cyclin E kinase: A key factor in determining gender differences in hepatocarcinogenesis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Castration; Cell Proli | 2016 |
Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Comet Assay; Cyclo | 2015 |
DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Culture | 2016 |
Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Blotting, Western; Carcinogenesis; Carcinoma, Hep | 2016 |
Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Carcinoma, Hepatocellular; | 2015 |
Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Diethylnitrosamine; Disease Models, Animal; eIF-2 | 2016 |
Dietary Broccoli Lessens Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and Fed a Western or Control Diet.
Topics: Alanine Transaminase; Animals; Brassica; Carcinoma, Hepatocellular; Diet, Western; Diethylnitrosamin | 2016 |
CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus-positive patients with resected hepatocellular carcinoma.
Topics: Aged; Aged, 80 and over; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; | 2016 |
Myricetin Selectively Induces Apoptosis on Cancerous Hepatocytes by Directly Targeting Their Mitochondria.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Apop | 2016 |
Soy Protein Isolate Protects Against Ethanol-Mediated Tumor Progression in Diethylnitrosamine-Treated Male Mice.
Topics: Adenoma; Alkylating Agents; Animals; Blotting, Western; Carcinoma, Hepatocellular; Diet; Diethylnitr | 2016 |
Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease.
Topics: Alanine Transaminase; alpha-Fetoproteins; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cel | 2016 |
Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; | 2016 |
Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling.
Topics: Adult; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neopl | 2016 |
Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms.
Topics: Animals; Antineoplastic Agents; bcl-2-Associated X Protein; bcl-X Protein; Carcinogenesis; Carcinoma | 2016 |
Brief Communication: Featured Article: Histone H2A mono-ubiquitination and cellular transformation are inversely related in N-nitrosodiethylamine-induced hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neopl | 2016 |
Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carcinogenesis; Carcinoma, Hepatocellular; Ce | 2016 |
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Survival; Diethylnitrosamine; Gene Expression Regulation, N | 2016 |
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine.
Topics: Animals; Biomarkers; Body Weight; Carcinoma, Hepatocellular; Choline Deficiency; Diet, High-Fat; Die | 2016 |
Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs.
Topics: Adenoma; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2016 |
TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2016 |
Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model.
Topics: Angiography; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease Models, | 2017 |
Caspase-2 deficiency accelerates chemically induced liver cancer in mice.
Topics: Animals; Carcinoma, Hepatocellular; Caspase 2; Cell Death; Cell Proliferation; Diethylnitrosamine; D | 2016 |
Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biological Products; Carcinoma, Hepatoce | 2016 |
Dietary zinc deficiency predisposes mice to the development of preneoplastic lesions in chemically-induced hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Animals, Newborn; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Ce | 2016 |
Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
Topics: Animals; Autophagy; Carcinogenesis; Carcinoma, Hepatocellular; Death-Associated Protein Kinases; Die | 2016 |
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode | 2017 |
Biochemical and molecular evidences for the antitumor potential of Ginkgo biloba leaves extract in rodents.
Topics: Anaplasia; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation; Ginkg | 2017 |
Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma.
Topics: Animals; beta-Arrestin 2; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement | 2016 |
Protective effects of dieckol on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzofurans; Biomarkers; Carcinoma, Hepatocellular; | 2016 |
The antitumor activity of a lactosaminated albumin conjugate of doxorubicin in a chemically induced hepatocellular carcinoma rat model compared to sorafenib.
Topics: Animals; Antibiotics, Antineoplastic; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosami | 2017 |
Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles.
Topics: Animals; Carcinoma, Hepatocellular; Carotenoids; Cell Proliferation; Diethylnitrosamine; Drug Delive | 2017 |
Detection and differentiation of early hepatocellular carcinoma from cirrhosis using CT perfusion in a rat liver model.
Topics: Animals; Area Under Curve; Blood Flow Velocity; Capillary Permeability; Carcinoma, Hepatocellular; C | 2016 |
A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Diethylnitros | 2016 |
DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; Geneti | 2017 |
Fruiting Bodies of Antrodia cinnamomea and Its Active Triterpenoid, Antcin K, Ameliorates N-Nitrosodiethylamine-Induced Hepatic Inflammation, Fibrosis and Carcinogenesis in Rats.
Topics: Alkylating Agents; Animals; Antrodia; Apoptosis; Autophagy; Carcinogenesis; Carcinoma, Hepatocellula | 2017 |
miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver.
Topics: Animals; Calpain; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethylnitrosamine; | 2017 |
The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents, Immunological; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proli | 2017 |
Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.
Topics: Animals; beta Catenin; beta Karyopherins; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line | 2017 |
Absence of Malat1 does not prevent DEN-induced hepatocarcinoma in mice.
Topics: Animals; Blood Glucose; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Deletion; Gene Expressio | 2017 |
Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Topics: Acetyl-CoA Carboxylase; Alkylating Agents; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatoc | 2017 |
Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice.
Topics: Actins; Animals; Antigens, Nuclear; Aurora Kinase A; Aurora Kinases; Carcinogens; Carcinoma, Hepatoc | 2008 |
Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Antioxidants; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; | 2008 |
Effect of DENA induced hepatocarcinogenesis on neuroendocrine levels in male rats.
Topics: Animals; Brain; Carcinoma, Hepatocellular; Diethylnitrosamine; Dopamine; gamma-Glutamyltransferase; | 2008 |
Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Diter | 2009 |
Promoting effect of o-aminoazotoluene on hepatocarcinogenesis is accompanied by the increase in inflammatory and proliferative processes in liver tissue and decrease in the concentration of free thyroxin in the blood.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Female; Inf | 2007 |
Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques.
Topics: Animals; beta Catenin; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosa | 2008 |
Hepatocyte-specific activation of NF-kappaB does not aggravate chemical hepatocarcinogenesis in transgenic mice.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Electro | 2009 |
Suppressive effect of Siraitia grosvenorii extract on dicyclanil-promoted hepatocellular proliferative lesions in male mice.
Topics: Alkylating Agents; Animals; Antioxidants; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Cell | 2009 |
Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease M | 2009 |
[The expression of B-cell translocation gene 2 in diethylnitrosamine-induced primary hepatocellular carcinoma rat model.].
Topics: Animals; B-Lymphocytes; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatocytes; Liver Neoplasms; | 2009 |
Measuring microenvironment mechanical stress of rat liver during diethylnitrosamine induced hepatocarcinogenesis by atomic force microscope.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver; Liver Neoplasms; Microsc | 2009 |
Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Gene Expression Regulati | 2009 |
The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Blotting, Western; Carcinoma, Hepatocellular; | 2009 |
Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences.
Topics: Alkylating Agents; Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neopl | 2009 |
Effect of selenium-enriched malt on hypoglycemia and regulatory hormones in diethylnitrosamine-induced hepatocarcinoma SD rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Edible Grain; Hypoglycemia; Liver Neoplasms; | 2009 |
Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Carci | 2009 |
[Differentially expressed proteins in the precancerous stage of rat hepatocarcinogenesis induced by diethylnitrosamine].
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Diethylnitrosamine; gamma-Glutamyltransferase | 2009 |
Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Cyclin D1; Diethylnitrosamine; DN | 2010 |
Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Diethylnitro | 2010 |
Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Caspase 3; Ce | 2010 |
Cytokeratin 8/18 is a useful immunohistochemical marker for hepatocellular proliferative lesions in mice.
Topics: Adenoma; Animals; Biomarkers; Carcinoma; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatectomy; | 2010 |
BRE over-expression promotes growth of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Humans; Liver; Liver Neo | 2010 |
Evaluation of the protective effect of ascorbic acid on nitrite- and nitrosamine-induced cytotoxicity and genotoxicity in human hepatoma line.
Topics: Antioxidants; Ascorbic Acid; Carcinoma, Hepatocellular; Cell Survival; Comet Assay; Cytoprotection; | 2010 |
Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats.
Topics: Adenosine Triphosphatases; Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, | 2009 |
The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; D | 2010 |
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Extracellular Signal-Reg | 2010 |
The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Profiling; Gene Expression R | 2010 |
Application of magnetic resonance imaging in transgenic and chemical mouse models of hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; G | 2010 |
Preventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on DEN-induced hepatocarcinogenesis in rats.
Topics: Animals; Apoptosis; Benzenesulfonates; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferat | 2010 |
Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet).
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Carc | 2010 |
Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Base Sequence; Carcinoma, Hepatocellu | 2010 |
Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Blotting, Western; Carcinoma, Hepatocellular; Diethylni | 2011 |
Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro.
Topics: Adenoviridae; Alkylating Agents; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Lin | 2010 |
Resistance to cisplatin-induced apoptosis via PI3K-dependent survivin expression in a rat hepatoma cell line.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultu | 2010 |
Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Primers; DNA, Complem | 2010 |
Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling.
Topics: Acetylcysteine; Administration, Oral; Animals; Apoptosis; beta Catenin; Carcinoma, Hepatocellular; C | 2010 |
Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; | 2010 |
Preparation of 177Lu-labeled oxine in lipiodol as a possible agent for therapy of hepatocellular carcinoma: a preliminary animal study.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Evaluation, Preclinical; Ethiodized Oil | 2010 |
Dissection of DEN-induced platelet proteome changes reveals the progressively dys-regulated pathways indicative of hepatocarcinogenesis.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Blood Platelets; Blotting, Western; Carcinoma, Hepatocellul | 2010 |
Production of liver preneoplasia and gallbladder agenesis in turkey fetuses administered diethylnitrosamine.
Topics: Animals; Biological Assay; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response | 2011 |
Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver.
Topics: Adult Stem Cells; Animals; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Diethylnitrosam | 2011 |
Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; | 2011 |
Estrogen suppresses metastasis in rat hepatocellular carcinoma through decreasing interleukin-6 and hepatocyte growth factor expression.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Estrogens; Ethinyl Estradiol; Female; Hepato | 2012 |
Aberrant expression of the p53-inducible antiproliferative gene BTG2 in hepatocellular carcinoma is associated with overexpression of the cell cycle-related proteins.
Topics: Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, | 2011 |
Of mice and men: the nonrandom genomic instability in hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Genes, myc; | 2011 |
Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carcinoma, Hepatocellular; Comparative Genomic Hybridization; Core Binding Fa | 2011 |
Polyol profile as an early diagnostic and prognostic marker in natural product chemoprevention of hepatocellular carcinoma in diabetic rats.
Topics: Aldehyde Reductase; Allyl Compounds; alpha-Fetoproteins; Animals; Ascorbic Acid; Blood Glucose; Carc | 2011 |
Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.
Topics: Alkylating Agents; Animals; Antioxidants; Blotting, Western; Carcinoma, Hepatocellular; Diethylnitro | 2011 |
Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell | 2011 |
Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Cyclophosphamide; Die | 2011 |
Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carcinoma, Hepatocellular; | 2011 |
Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Ca | 2011 |
Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation, Neo | 2011 |
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Gene Express | 2011 |
Inhibitory effect of phytoglycoprotein (24 kDa) on hepatocarcinogenesis in N-nitrosodiethylamine-treated ICR mice.
Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; Cyclo | 2011 |
RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Chromosome Aberrations; Comparat | 2011 |
PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biopsy, Needle; Blotting, W | 2011 |
c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; C | 2011 |
Non-invasive monitoring of hepatocellular carcinoma in transgenic mouse with bioluminescent imaging.
Topics: alpha-Fetoproteins; Animals; Animals, Newborn; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethyln | 2011 |
Potential chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis in rats: myrrh (Commiphora molmol) vs. turmeric (Curcuma longa).
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Curcuma; Diet | 2012 |
Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cymenes; | 2012 |
Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; DNA Pr | 2012 |
Anticarcinogenic activity of nanoencapsulated quercetin in combating diethylnitrosamine-induced hepatocarcinoma in rats.
Topics: Alkylating Agents; Animals; Antioxidants; Blotting, Western; Capsules; Carcinoma, Hepatocellular; Cy | 2012 |
Activity of tumor necrosis factor-α blocked by phytoglycoprotein (38 kDa) at initiation stage in N-nitrosodiethylamine-induced ICR mice.
Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Catalase; Diethyl | 2012 |
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) promotes mouse hepatocarcinogenesis by activating transforming growth factor-β and Wnt/β-catenin signaling pathways.
Topics: Animals; beta Catenin; Blotting, Western; Body Weight; Carcinoma, Hepatocellular; Cell Adhesion; Cel | 2012 |
Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma.
Topics: Adult; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line, Tumor; Cell Proliferatio | 2012 |
Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced hepatocellular carcinoma.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Dr | 2012 |
STAT3 activation in monocytes accelerates liver cancer progression.
Topics: Aminosalicylic Acids; Analysis of Variance; Animals; Apoptosis; Benzenesulfonates; Carcinogens; Carc | 2011 |
Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; b | 2012 |
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer.
Topics: Adaptive Immunity; Animals; B-Lymphocytes; Biomarkers; Carcinogens; Carcinoma, Hepatocellular; Chemo | 2012 |
The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats.
Topics: Animals; Carcinoma, Hepatocellular; Cynara scolymus; Diethylnitrosamine; Dose-Response Relationship, | 2011 |
Preventive effect of caffeine and curcumin on hepato-carcinogenesis in diethylnitrosamine-induced rats.
Topics: Animals; Anticarcinogenic Agents; Caffeine; Carcinoma, Hepatocellular; Curcumin; Diethylnitrosamine; | 2012 |
Autologous bone marrow cell infusions suppress tumor initiation in hepatocarcinogenic mice with liver cirrhosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Carcinoma, | 2012 |
Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice.
Topics: Alkylating Agents; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular | 2012 |
Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; gamma-Glutamyltransferas | 2012 |
The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Proliferation; Cell Shape; Cel | 2012 |
Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing.
Topics: Analysis of Variance; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal | 2012 |
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; D | 2012 |
Efficient enrichment of hepatic cancer stem-like cells from a primary rat HCC model via a density gradient centrifugation-centered method.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Differentiation; Cell Movement; Cell Proliferat | 2012 |
Selenium supplementation reduced oxidative stress in diethylnitrosamine-induced hepatocellular carcinoma in rats.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Dietary Supplements; Diethylnitrosamine; Liver Neo | 2011 |
Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Transformat | 2012 |
Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Anti-Bacterial Agents; Bifidobacterium; Carcinoma, Hepatocellular; Cytok | 2012 |
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Deletion; Genet | 2012 |
In vivo bioluminescent imaging of α-fetoprotein-producing hepatocellular carcinoma in the diethylnitrosamine-treated mouse using recombinant adenoviral vector.
Topics: Adenoviridae; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitro | 2012 |
Myrtenal, a natural monoterpene, down-regulates TNF-α expression and suppresses carcinogen-induced hepatocellular carcinoma in rats.
Topics: Animals; Bicyclic Monoterpenes; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Exp | 2012 |
Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats.
Topics: alpha-Fetoproteins; Animals; Anticarcinogenic Agents; Carbon Tetrachloride; Carcinoembryonic Antigen | 2012 |
Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Progr | 2013 |
Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl4-induced hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Body Weight; Carbon Tetrachloride; Ca | 2012 |
Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; E | 2013 |
Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice.
Topics: Alkylating Agents; Animals; Autophagy; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; C | 2013 |
Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Anthocyanins; Antioxidants; Blotting, Western; Carcinoma, Hepatocellular | 2012 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepat | 2012 |
Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethylnitrosamine; Humans; L | 2013 |
Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cell Prolifera | 2014 |
Increased expression of chondroitin sulphate proteoglycans in rat hepatocellular carcinoma tissues.
Topics: Animals; Carcinoma, Hepatocellular; Chondroitin Sulfate Proteoglycans; Diethylnitrosamine; Liver Neo | 2012 |
SJSZ glycoprotein (38 kDa) modulates macrophage type 1/2-related factors at hepatocarcinogenic stage in N-nitrosodiethylamine-treated Balb/c.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Glycoprot | 2013 |
Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor.
Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Blood Proteins; Calcium Sign | 2013 |
The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamin | 2013 |
Constitutive Notch2 signaling induces hepatic tumors in mice.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cell Differentiat | 2013 |
Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice.
Topics: Animals; Antigens, Nuclear; Apoptosis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; D | 2013 |
Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Progression; Gen | 2013 |
Notch2 signaling and undifferentiated liver cancers: evidence of hepatic stem/progenitor cell origin.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylni | 2013 |
Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Nucleus; Diet, High-Fat; Diethylnitrosamine; Fa | 2013 |
[Influence of bear bile on rat hepatocarcinoma induced by diethylnitrosamine].
Topics: Actins; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Bile; Bil | 2012 |
Overexpression of cyclin D1 is associated with the decondensation of chromatin during den-induced sequential hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chromatin; Cyclin D1; Diethylni | 2002 |
Demonstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; beta-Galactosidase; Carcinoma, Hepatocell | 2002 |
Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control.
Topics: Activins; Adenoma; Alternative Splicing; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell | 2002 |
Dietary influence of selenium on the incidence of N-nitrosodiethylamine-induced hepatoma with reference to drug and glutathione metabolizing enzymes.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepatocell | 2002 |
A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III (GnT-III) transgenic mice induced by diethylnitrosamine (DEN): identification of haptoglobin as a target molecule of GnT-III.
Topics: Animals; Carbohydrate Sequence; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Electrop | 2002 |
Relationship between the imaging features and pathologic alteration in hepatoma of rats.
Topics: Alkylating Agents; Angiography, Digital Subtraction; Animals; Carcinoma, Hepatocellular; Cell Transp | 2003 |
Tumor promotion by metanil yellow and malachite green during rat hepatocarcinogenesis is associated with dysregulated expression of cell cycle regulatory proteins.
Topics: Animals; Azo Compounds; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Transformation, Neoplas | 2003 |
Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen.
Topics: Acyl Coenzyme A; Acyl-CoA Oxidase; Animals; Biomarkers, Tumor; Blotting, Northern; Carcinoma, Hepato | 2003 |
Influence of sodium selenite on glycoprotein contents in normal and N-nitrosodiethylamine initiated and phenobarbital promoted rat liver tumors.
Topics: Animals; Biomarkers; Blood Proteins; Carcinoma, Hepatocellular; Diethylnitrosamine; Glycoproteins; H | 2003 |
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].
Topics: Aging; Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Cyclin-Dependent Kinase In | 2003 |
Selective accumulation of ALA-induced PpIX and photodynamic effect in chemically induced hepatocellular carcinoma.
Topics: Alkylating Agents; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylni | 2003 |
STAT-3 activity in chemically-induced hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Antineoplastic Agents, Hormonal; Blotting, Northe | 2003 |
Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; DNA-Binding Prot | 2003 |
[The histogenesis and cytogenesis of liver carcinoma in the rat due to diethylnitrosamine in the light microscopic picture].
Topics: Animals; Carcinoma, Hepatocellular; Cytogenetics; Diethylnitrosamine; Liver Neoplasms; Microscopy; R | 1962 |
HISTOLOGICAL AND ENZYMATIC CHANGES IN THE LIVERS OF RATS FED THE HEPATIC CARCINOGEN DIETHYLNITROSAMINE.
Topics: Carboxy-Lyases; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dopa Decarboxylase; Hist | 1963 |
[ON THE MORPHOLOGY OF DIETHYLNITROSAMINE-INDUCED LIVER TUMORS IN MICE AND GUINEA PIGS].
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Guinea Pigs; Hemangioendothelioma; Liver Neo | 1963 |
[CHANGES IN METABOLIC PARAMETERS AND GLYCOLYTIC ENZYME ACTIVITIES DURING THE CANCERIZATION OF RAT LIVERS BY DIETHYLNITROSAMINE].
Topics: Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose-6-Phosp | 1964 |
[THE HEXOKINASE ACTIVITY IN THE MITOCHONDRIA OF THE PRECANCEROUS RAT LIVER AND TRANSPLANTED DIETHYLNITROSAMINE HEPATOMA].
Topics: Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; | 1964 |
[QUANTITATIVE ANALYSIS OF THE CARCINOGENIC EFFECT OF DIETHYLNITROSAMINE].
Topics: Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA; DNA, Neoplasm; Esophageal Neoplasms | 1963 |
[ON ANTIGENIC CHARACTERISTICS OF HEPATOMAS PRODUCED IN RATS WITH N-NITROSODIETHYLAMINE].
Topics: Antigens; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethylamines; Liver Neoplasms; Neoplasms; Ne | 1964 |
TNP-470 inhibits oxidative stress, nitric oxide production and nuclear factor kappa B activation in a rat model of hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Blotting, Western; Body Weight; Carcinoma, Hepatocellular; Cyc | 2003 |
Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver.
Topics: Amino Acid Substitution; Animals; Base Sequence; Carcinoma, Hepatocellular; Connexins; Diethylnitros | 2004 |
Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Diethyl | 2004 |
Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Antineoplastic Agents; Ardisia; Carcinogens; Ca | 2004 |
Preventive effect of Ganfujian granule on experimental hepatocarcinoma in rats.
Topics: Alkylating Agents; Animals; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Division; Diethylnitr | 2004 |
Alterations of the M6p/Igf2 receptor gene in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Choline Deficiency; Codon; Colchi | 2004 |
Heterozygous p53-deficient (+/-) mice develop fewer p53-negative preneoplastic focal liver lesions in response to treatment with diethylnitrosamine than do wild-type (+/+) mice.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cycl | 2004 |
A modified rat model for hepatocellular carcinoma.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Laparot | 2004 |
Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Er | 2005 |
Interferon-gamma-mediated hepatocarcinogenesis in mice treated with diethylnitrosamine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; Cyt | 2005 |
Efficacy of Terminalia arjuna (Roxb.) on N-nitrosodiethylamine induced hepatocellular carcinoma in rats.
Topics: Animals; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethanol; Liver; Liv | 2005 |
Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent.
Topics: Alkyl and Aryl Transferases; Animals; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; | 2005 |
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasm | 2005 |
In vivo detection of metabolic changes by 1H-MRS in the DEN-induced hepatocellular carcinoma in Wistar rat.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, Animal | 2005 |
Suppression of beta-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats.
Topics: Animals; Antioxidants; beta Catenin; Carcinoma, Hepatocellular; Citrus; Coumarins; Cytoskeletal Prot | 2005 |
Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Doxorub | 2005 |
Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Cell | 2005 |
Melatonin modulates the oxidant-antioxidant imbalance during N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Liver Neoplas | 2005 |
Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Antigens, Polyomavirus Transforming; Carcinoma, Hepatocellular; Cell Lin | 2005 |
Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine.
Topics: Alkylating Agents; Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode | 2005 |
Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chemokine CCL3; Chemokine CCL4; Diethylnitros | 2006 |
Antioxidant activity of Terminalia arjuna bark extract on N-nitrosodiethylamine induced hepatocellular carcinoma in rats.
Topics: Alkylating Agents; Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Lipid Perox | 2006 |
[Ratio of low- and high-spin cytochrome P-450 in liver microsomes of N-nitrosodiethylamine-induced hepatomas].
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Sy | 2005 |
High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine.
Topics: Alkylating Agents; Animals; beta-Galactosidase; Carcinogens; Carcinoma, Hepatocellular; Cytomegalovi | 2006 |
Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Enzyme Activation; I-kapp | 2006 |
Chemopreventive activity of a macrofungus Phellinus rimosus against N-nitrosodiethylamine induced hepatocellular carcinoma in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Fungi | 2006 |
Overexpression of cyclin D1 is associated with elevated levels of MAP kinases, Akt and Pak1 during diethylnitrosamine-induced progressive liver carcinogenesis.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cyclin D1; Diethylnitrosamine; Disease Progression; | 2007 |
In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, | 2006 |
Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinoma, Hepatocellular; Cocarcinogenesis; Diethylnitrosamine; DN | 2006 |
Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin.
Topics: Animals; Antibiotics, Antineoplastic; Bone Marrow; Carbon Radioisotopes; Carcinoma, Hepatocellular; | 2007 |
Effect of Bauhinia racemosa stem bark on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.
Topics: Alanine Transaminase; Alkylating Agents; Animals; Antioxidants; Aspartate Aminotransferases; Bauhini | 2007 |
Expression of ErbB receptor proteins and TGF-alpha during diethylnitrosamine-induced hepatocarcinogenesis in the rat liver.
Topics: Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; ErbB Receptors; Glutath | 2007 |
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2007 |
Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Adhesion Molecules, Neuronal; Diet | 2007 |
The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinogens; | 2007 |
Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats.
Topics: Amino Acids; Animal Feed; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; DNA Mutat | 2007 |
Changes in the antioxidant system by TNP-470 in an in vivo model of hepatocarcinoma.
Topics: Angiogenesis Inhibitors; Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cyclohexanes | 2007 |
Prevention by melatonin of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cell Transfor | 2007 |
RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Chromosomal Instability; Diethylnitrosamine; Disease | 2007 |
Inhibition of early preneoplastic events in the rat liver by the somatostatin analog lanreotide.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Liver | 2007 |
Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Body Weight; Carcinoembryonic Antigen; Carcinoma, Hepatoc | 2008 |
Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.
Topics: Animals; Animals, Genetically Modified; Carcinogens; Carcinoma, Hepatocellular; Cell Communication; | 2007 |
Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice.
Topics: Alkylating Agents; Animals; Apoptosis; Benzamides; Carcinoma, Hepatocellular; Cell Proliferation; Ch | 2008 |
Hepatocellular carcinoma and sex.
Topics: Alanine Transaminase; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal | 2007 |
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcinogens; Carcinoma, Hepatocel | 2007 |
Sodium selenite enhances glutathione peroxidase activity and DNA strand breaks in hepatoma induced by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Alanine Transaminase; Animals; Body Weight; Carcinoma, Hepatocellular; Comet Assay; Diethylnitrosami | 2008 |
Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cimeti | 2008 |
Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Growth Differe | 2008 |
Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Algorithms; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethy | 2008 |
24-hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or alpha-ketoglutarate.
Topics: Alanine Transaminase; alpha-Fetoproteins; Animals; Antioxidants; Aspartate Aminotransferases; Carcin | 2008 |
Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma.
Topics: Animals; Arachidonic Acid; Carcinoma, Hepatocellular; Cholesterol, HDL; Cyclooxygenase 2; Diethylnit | 2008 |
TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin B; | 2008 |
Transplanted bone marrow stromal cells are not cellular origin of hepatocellular carcinomas in a mouse model of carcinogenesis.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carcinoma, Hepatocellular; Cell Differentia | 2008 |
[Ultrastructure of human hepatic carcinomas compared with ultrastructural findings in hepatomas induced by chemical agents in Wistar rats and the golden hamster].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Cricetinae | 1983 |
Absence of the ether lipid tumour marker in diethylnitrosamine-induced rat liver cell cancer.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethers; Lipids; Liver; Liver Neoplasms; Male | 1981 |
Role of estrogens as promoters of hepatic neoplasia.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Diethylstilbestrol; Dose-Response Relationsh | 1982 |
Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fibronectins; Glycopr | 1982 |
A histological study of the promotive effect of diethylstilbestrol on diethylnitrosamine initiated carcinogenesis of liver in rat.
Topics: Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Diethylnitrosamine; Diethylstilbestrol; Female | 1984 |
Cytokeratin patterns of liver carcinomas induced by diethylnitrosamine in monkeys.
Topics: Animals; Antibodies, Monoclonal; Carcinoma, Hepatocellular; Chlorocebus aethiops; Diethylnitrosamine | 1995 |
Enhanced hepatocyte colony growth in soft agar after in vivo treatment with a genotoxic carcinogen: a potential assay for hepatocarcinogens?
Topics: Agar; Animals; Carcinogenicity Tests; Carcinoma, Hepatocellular; Cells, Cultured; Contact Inhibition | 1995 |
Hepatocarcinogenesis in p53-deficient mice.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Dosage; Genes, p53; Liver Neoplasms; Ma | 1995 |
Number of simultaneously expressed enzyme alterations correlates with progression of N-ethyl-N-hydroxyethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Adenosine Triphosphatases; Animals; Biomarkers; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell D | 1993 |
Constitutive expression of functional P-glycoprotein in rat hepatoma cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Carrier | 1994 |
Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; D | 1993 |
Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellula | 1994 |
Decreased dimethylnitrosamine-induced O6- and N7-methyldeoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Deoxyguanosine; Diethylnitrosam | 1993 |
Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Female; Liver; Liver | 1993 |
High sensitivity of LEC rats with chronic hepatitis to hepatocarcinogenesis: decreases in unscheduled and replicative DNA synthesis of the hepatocytes.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Chronic Disease; Diethylnitrosamine; DNA; Epiderm | 1993 |
Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Erythrocytes; Female; Hydroxymethylbilane Sy | 1995 |
Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice.
Topics: Animals; Antineoplastic Agents; Cadmium; Carcinoma, Hepatocellular; Diethylnitrosamine; Down-Regulat | 1996 |
Sinusoidal capillarization and arterial blood supply continuously proceed with the advance of the stages of hepatocarcinogenesis in the rat.
Topics: Animals; Capillaries; Carcinoma, Hepatocellular; Diethylnitrosamine; Factor VIII; Hyperplasia; Liver | 1996 |
c-myc amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model.
Topics: Adenoma; Animals; Blotting, Northern; Blotting, Southern; Carcinoma, Hepatocellular; Deoxyribonuclea | 1996 |
Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Adenoviridae; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Ganciclovir; Gene Transfer Tec | 1997 |
Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis.
Topics: Aged; Animals; Carcinogens; Carcinoma, Hepatocellular; Carrier Proteins; Cholesterol; Diethylnitrosa | 1997 |
Correlation between Bcl-2 expression and histopathology in diethylnitrosamine-induced mouse hepatocellular tumors.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Immunohistochemistry; Liver Neo | 1997 |
Chronic liver injury promotes hepatocarcinogenesis of the LEC rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Copper; Dieth | 1998 |
Enhanced expression of a new class of liver-enriched b-Zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Carcinogens; Carcinoma, Hepatocellular; Cell Di | 1998 |
Differential expression of the polyspecific drug transporter OCT1 in rat hepatocarcinoma cells.
Topics: Animals; Biological Transport; Carcinogens; Carcinoma, Hepatocellular; Carrier Proteins; Diethylnitr | 1998 |
The outcome of liver transplantation at various times (70, 120, and 134 days) after the initiation of carcinogenesis in rats.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Liver N | 1998 |
Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Biopsy, Needle; Carcinoma, Hepatocellular; Diethylnitros | 1998 |
Enhanced in vivo adenovirus-mediated gene transfer to rat hepatocarcinomas by selective administration into the hepatic artery.
Topics: Adenoviridae; Animals; beta-Galactosidase; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expre | 1998 |
Hepatocellular carcinoma is induced by a subnecrogenic dose of diethylnitrosamine in previously fasted-refed rats.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Dru | 1998 |
Environmental complex mixture toxicity assessment.
Topics: Adenoma, Liver Cell; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Chromat | 1998 |
Beta-catenin mutations are frequent in hepatocellular carcinomas but absent in adenomas induced by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; beta Catenin; Carcinoma, Hepatocellular; Cytoskeletal Proteins; Diethylnitrosamine | 1999 |
Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle; Chick Embryo; Colonic Neopla | 1999 |
Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine.
Topics: Adenoma, Bile Duct; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Immunohistoch | 1999 |
Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Chromosome Mapping; Diethylnitrosamine; G | 1999 |
Effects of dietary iron overload on progression in chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Ch | 1999 |
Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model.
Topics: Animals; Cadherins; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anim | 1999 |
Bile acid secretion during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Bile; Carcinoma, Hepatocellular; Cell Differ | 2000 |
Genome-wide loss of heterozygosity analysis of chemically induced rat hepatocellular carcinomas reveals elevated frequency of allelic imbalances on chromosomes 1, 6, 8, 11, 15, 17, and 20.
Topics: Alleles; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation, Neoplas | 2000 |
Enhancement of chemical hepatocarcinogenesis by the HIV-1 tat gene.
Topics: Adenoma, Liver Cell; Animals; Basophils; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; | 2000 |
Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; gamma-Glutamyltransferase | 2000 |
Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; CDC2 Protein Kinase; Cell Cycle Proteins; Che | 2000 |
Early exposure to restraint stress enhances chemical carcinogenesis in rat liver.
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Glutathione Transf | 2000 |
Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12.
Topics: Adenoviridae; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Diethylnitrosamine; Geneti | 2001 |
Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; DNA-Binding Prot | 2001 |
Long-term dehydroepiandrosterone and 16alpha-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesions in liver of diethylnitrosamine-initiated rats.
Topics: Animals; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Diet; Diethylnitrosamine; DNA; DNA Repli | 2001 |
Effect of selenium on N-nitrosodiethylamine-induced multistage hepatocarcinogenesis with reference to lipid peroxidation and enzymic antioxidants.
Topics: Alkylating Agents; Animals; Antioxidants; Carcinoma, Hepatocellular; Catalase; Cell Membrane; Diethy | 2001 |
Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice.
Topics: Animals; Blotting, Northern; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Primers; Female; Hum | 2001 |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce | 2001 |
Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats.
Topics: 5-alpha Reductase Inhibitors; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Diethyln | 2001 |
Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carcinogenicity Tests; Carcinoma, Hepatocellular; C | 2001 |
Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters.
Topics: Adenoviridae; Alkylating Agents; Animals; Anticonvulsants; beta-Galactosidase; Carcinoma, Hepatocell | 2001 |
The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility.
Topics: Animals; Bromodeoxyuridine; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Gene | 2001 |
Anticarcinogenic effect of red ginseng on the development of liver cancer induced by diethylnitrosamine in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Data Interpretation, Statistical; Dieth | 2001 |
Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats.
Topics: Alkylating Agents; Animals; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Cell Division; Chol | 2001 |
Effects of fasting and intermittent fasting on rat hepatocarcinogenesis induced by diethylnitrosamine.
Topics: Alkylating Agents; Animals; Basophils; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progre | 2002 |
Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine.
Topics: Alkylating Agents; Animals; Autocrine Communication; Carcinoma, Hepatocellular; Diethylnitrosamine; | 2002 |
Distinctive gene expression of receptor-type tyrosine kinase families during rat hepatocarcinogenesis.
Topics: Amino Acid Sequence; Animals; Blotting, Southern; Carcinoma, Hepatocellular; Cloning, Molecular; Die | 2002 |
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Fluorenes; gamm | 1977 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Diethylnitrosam | 1978 |
Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; gamma-Glu | 1978 |
Flow microfluorometric identification of liver cells with elevated gamma-glutamyltranspeptidase activity after carcinogen exposure.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Diethylnitrosamine; Female; gamma-Glutamyltransferase | 1979 |
Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet.
Topics: Amino Acids; Animals; Body Weight; Carcinoma, Hepatocellular; Choline; Diet; Dietary Fats; Diethylni | 1977 |
In vitro alpha-fetoprotein synthesis by monkey hepatocellular carcinoma.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Haplorhini; In V | 1978 |
Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression.
Topics: Animals; Antilymphocyte Serum; Carcinoma, Hepatocellular; Diethylnitrosamine; Hydroxyurea; Immunosup | 1975 |
Protective tumor immunity induced by potassium chloride extracts of guinea pig hepatomas.
Topics: Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Diethylnitrosamine; Guinea Pigs; Immunizatio | 1975 |
Effect of a single treatment with the alkylating carcinogens dimethynitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. I. Test for induction of liver carcinomas.
Topics: Adenocarcinoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethylnitrosamine; Female; | 1975 |
[The tumor-tetanus assay--experimental studies on the biological differentiation between carcinogenesis and organ regeneration of the rat (author's transl)].
Topics: Agglutination Tests; Animals; Antibodies, Neoplasm; Antibody Formation; Carcinoma 256, Walker; Carci | 1975 |
The phosphorylation of nuclear proteins in the regenerating and premalignant rat liver and its significance for cell proliferation.
Topics: Animals; Binding Sites; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, Neoplastic; C | 1975 |
Histologic and electron microscopy observations on diethylnitrosamine-induced hepatomas in small aquarium fish (Oryzias latipes).
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Endoplasmic Reticulum; Fishes; Golgi Apparat | 1975 |
[Studies on the influence of anticoagulants on metastase formation of autochthonic hepatomas in the rat (author's transl)].
Topics: Animals; Anticoagulants; Aspirin; Carcinoma, Hepatocellular; Coumarins; Diethylnitrosamine; Female; | 1975 |
Kinetics of induction and growth of precancerous liver-cell foci, and liver tumour formation by diethylnitrosamine in the rat.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Count; Diethylnitrosamine; Dose- | 1975 |
Proceedings: Glucocorticoid receptors and response in diethylnitrosamine-induced hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Dexamethasone; Diethylnitrosamine; Liver Neoplasms; Male; Neopla | 1975 |
[Several properties of the nucleic acide of nuclei and mitochondria from hepatoma induced by N-nitroso-N-diethylamine].
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleus; Diethylnitrosamine; DNA, Neoplasm; Genotype; Liver | 1975 |
Kinetic properties of pyruvate kinase isolated from rat hepatic tumours.
Topics: Adenosine Triphosphate; Alanine; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Kinetics; L | 1976 |
Studies on the terminal stages of antibody-complement-mediated killing of a tumor cell. I. Evidence for the existence of an intermediate, T.
Topics: Animals; Antibodies; Carcinoma, Hepatocellular; Cell Line; Complement System Proteins; Cytotoxicity | 1976 |
Studies on the terminal stages of antibody-complement-mediated killing of a tumor cell. II. Inhibition of transformation of T to dead cells by 3'5' cAMP.
Topics: Animals; Antibodies; Carcinoma, Hepatocellular; Cell Nucleus; Cell Survival; Complement System Prote | 1976 |
Pituitary growth hormone and somatotrophs in rats bearing chemically induced hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Growth Hormone; Liver | 1976 |
Phalloidin tolerance in rats with liver carcinoma induced by diethylnitrosamine.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Tolerance; Lethal Dose 50; Liver Neopla | 1976 |
Composition, associated tissue methyltransferase activity, and catabolic end products of transfer RNA from carcinogen-induced hepatoma and normal monkey livers.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Guanine; Guanosine; Haplorhini; Hypo | 1977 |
Nucleic acids from subcellular fractions of N-nitrosodiethylamine-induced hepatoma in mice.
Topics: Acridines; Animals; Carcinoma, Hepatocellular; Cell Nucleus; Dactinomycin; Diethylnitrosamine; DNA, | 1976 |
Sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose-6-Phospha | 1976 |
[Polyadenylic acid rich RNA fractions in primary hepatomas induced with diethylnitrosamine].
Topics: Animals; Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry; Diethylnitrosamine; Liver Neoplas | 1976 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Synergism; Liver Neoplasms; Male; Neopl | 1976 |
Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver Neoplasms; Lung; Male; Mi | 1977 |
Comparability of histological alterations during carcinogenesis in animals and man, with special reference to hepatocarcinogenesis in fish.
Topics: Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fish Diseases; Humans; H | 1977 |
Altered cobalamin distribution in rat hepatomas and in the livers of rats treated with diethylnitrosamine.
Topics: Animals; Carcinoma, Hepatocellular; Cobamides; Diethylnitrosamine; Female; Liver; Liver Neoplasms; N | 1977 |
The induction of tumors in Rana temporaria with nitrosamines.
Topics: Adenoma; Animals; Anura; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethylnitrosamine; Hematop | 1977 |
Discussion: some comments on the potential carcinogenicity of the clinically useful antitumor agents.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Haplorhi | 1977 |
Susceptibility to and escape from complement-mediated lysis of guinea-pig hepatoma line-10.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Neoplasm; Carcinoma, Hepatocellular; Cell Line; Chr | 1977 |
Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Haplorhini; Hepati | 1977 |
Hepatic cell loss and proliferation induced by N-2-fluorenylacetamide, diethylnitrosamine, and aflatoxin B1 in relation to hepatoma induction.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosa | 1977 |
Tumor frequency and characteristics after a single dose of dimethylnitrosamine or diethylnitrosamine in partially hepatectomized rats.
Topics: Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethyl | 1977 |
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma].
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hexokinase; Isoenzymes; Liver Neoplasms; Neo | 1978 |
In vitro demonstration of Mallory body formation in liver cells from rats fed diethylnitrosamine.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; In Vitro Techniques; Liver; Liver Ne | 1978 |
Nucleic acids from subcellular fractions of N-nitrosodiethylamine-induced hepatoma in mice. II. Changes in gene expression during tumor progression.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA, Mitochondrial; DNA, Neoplasm; Liver Neo | 1978 |
[Role of hyperplasia in hepatic carcinogenesis].
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Mice; N | 1978 |
Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice.
Topics: Animals; Benzidines; Benzopyrenes; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethylnitrosourea; | 1978 |
Different deviation patterns of carbohydrate-metabolizing enzymes in primary rat hepatomas induced by different chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Cel | 1978 |
Carcinogenesis of N-nitrosodiethylamine (DENA) in chickens and domestic cats.
Topics: Adenocarcinoma; Administration, Oral; Animals; Animals, Domestic; Carcinogens; Carcinoma, Hepatocell | 1978 |
Guinea pig cell-mediated tumor immunity: the chromium release assay detects both cytolysis and serum blocking for syngeneic chemically-induced tumors.
Topics: Animals; Binding, Competitive; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chromium | 1979 |
Sequential analysis of hepatic carcinogenesis: a comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal, and regenerating liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Membrane; Cell Transformation, Neoplastic; Cytoskeleton; Di | 1979 |
Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Kidney; Kidney Neoplasms; Kidne | 1979 |
The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined diets.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA Pro | 1992 |
Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cytochrome P- | 1991 |
Enhanced expression of ganglioside GD3 in human and rat hepatocellular carcinoma cells and NIH 3T3 cells transfected with human tumor DNAs.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Carcinoma, Hepatocellular; CD57 Antigens; Cell Lin | 1990 |
The effects of alternating dietary restriction and ad libitum feeding of mice on the development of diethylnitrosamine-induced liver tumours and its correlation to insulinaemia.
Topics: Adenoma; Animals; Body Weight; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Eating; Female; | 1991 |
Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.
Topics: Adenoma; Aflatoxins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Gene Expression | 1991 |
Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepato | 1991 |
[Biological activity of hepatocellular carcinoma by analysing nuclear DNA ploidy patterns and using anti BrdU monoclonal antibody].
Topics: Aged; Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Nucleus; D | 1989 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Transplantable chemically-induced liver tumors in the viviparous fish Poeciliopsis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocell | 1985 |
The influence of metabolic liver defects on diethylnitrosamine (NDEA)-carcinogenesis in Gunn rats.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Hemangioendothelioma; Heman | 1985 |