diethylnitrosamine has been researched along with Fatty Liver in 23 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Interestingly, HFD, which induced hyperlipidemia and hepatic steatosis, attenuated DEN-related malnutrition and fibrosis progression in HFD + DEN group during 10-14 weeks." | 5.40 | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. ( Ding, WJ; Duan, XY; Fan, JG; Pan, Q; Qiao, L; Yan, SY, 2014) |
| "Recently, human non-alcholic steatohepatitis (NASH) has been focused of attention regarding hepatocellular carcinoma." | 5.34 | High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice. ( Fukushima, S; Hagihara, A; Iwai, S; Makino, S; Min, W; Mori, S; Morimura, K; Murai, T; Seki, S, 2007) |
| " Take advantage of the combinatory treatment with a single dose of diethylnitrosamine (DEN) and chronic feeding with high-fat diet (HFD), we demonstrated that hepatic depdc5 deletion did not aggravate DEN&HFD induced liver tumorigenesis, probably due to its protective effects on diet-induced liver steatosis." | 4.02 | Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice. ( Huang, R; Li, Z; Ma, H; Ma, J; Wang, J; Wang, Q; Xiong, X; Xu, L; Yang, C, 2021) |
| "Pitavastatin is effective in inhibiting the early phase of obesity-related liver tumorigenesis and, therefore, may be useful in the chemoprevention of liver cancer in obese individuals." | 3.77 | Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Sakai, H; Shimizu, M; Tanaka, T; Terakura, D; Tsurumi, H; Yasuda, Y, 2011) |
| "Diethylnitrosamine-induced hepatocellular carcinomas were then investigated in lean and diet-induced obese miR-22-deficient mice." | 1.72 | MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver. ( Ay, AS; Correia de Sousa, M; Delangre, E; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Sempoux, C; Sobolewski, C, 2022) |
| "In the DEN-treated mice, AICAR treatment reduced tumorigenesis, IL-6 signaling, and STAT3 activation." | 1.48 | The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN). ( Gao, J; Jiang, G; Xiong, D; Xiong, R; Yin, T; Yin, Z; Zhang, S; Zhang, X; Zhao, W, 2018) |
| "Diethylnitrosamine (DEN) was used to induce liver cancer in mice followed by actein treatment at different concentrations." | 1.46 | Actein ameliorates hepatobiliary cancer through stemness and p53 signaling regulation. ( Wang, LJ; Xi, R, 2017) |
| "Overnutrition can promote liver cancer in mice and humans that have liver damage caused by alcohol, viruses, or carcinogens." | 1.43 | Dietary sugar intake increases liver tumor incidence in female mice. ( Breen, DS; Byrne, FL; Caldwell, SH; Chow, JD; Hargett, SR; Healy, ME; Hoehn, KL; Kenwood, BM; Lackner, C; Lahiri, S; Taddeo, EP, 2016) |
| "Interestingly, HFD, which induced hyperlipidemia and hepatic steatosis, attenuated DEN-related malnutrition and fibrosis progression in HFD + DEN group during 10-14 weeks." | 1.40 | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. ( Ding, WJ; Duan, XY; Fan, JG; Pan, Q; Qiao, L; Yan, SY, 2014) |
| " Using this model, we investigated the efficacy of an equivalent dosage of dietary LY from either a pure compound or a tomato extract (TE) against NASH-promoted hepatocarcinogenesis." | 1.36 | Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. ( Ausman, LM; Greenberg, AS; Russell, RM; Wang, XD; Wang, Y, 2010) |
| "The current epidemics of type 2 diabetes mellitus (T2DM), non-alcoholic steatohepatitis (NASH), and Alzheimer's disease (AD) all represent insulin-resistance diseases." | 1.35 | Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease. ( de la Monte, SM; Lawton, M; Longato, L; Neusner, A; Tong, M; Wands, JR, 2009) |
| "Recently, human non-alcholic steatohepatitis (NASH) has been focused of attention regarding hepatocellular carcinoma." | 1.34 | High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice. ( Fukushima, S; Hagihara, A; Iwai, S; Makino, S; Min, W; Mori, S; Morimura, K; Murai, T; Seki, S, 2007) |
| "The average score of liver cirrhosis associated with HCV was 1." | 1.30 | Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. ( Hino, S; Kamahora, T; Kawasaki, H; Miyata, H; Shimada, A; Shiota, G; Shiraki, K; Terada, T, 1998) |
| "When phenobarbital was present in the diet, feeding the high polyunsaturated fat diet slightly increased the number of GGT-positive foci and the incidence of tumors." | 1.27 | Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats. ( Glauert, HP; Pitot, HC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 15 (65.22) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, L | 1 |
| Yang, C | 1 |
| Wang, J | 1 |
| Li, Z | 1 |
| Huang, R | 1 |
| Ma, H | 1 |
| Ma, J | 1 |
| Wang, Q | 1 |
| Xiong, X | 1 |
| Gjorgjieva, M | 1 |
| Ay, AS | 1 |
| Correia de Sousa, M | 1 |
| Delangre, E | 1 |
| Dolicka, D | 1 |
| Sobolewski, C | 1 |
| Maeder, C | 1 |
| Fournier, M | 1 |
| Sempoux, C | 1 |
| Foti, M | 2 |
| Alarcón-Sánchez, BR | 1 |
| Guerrero-Escalera, D | 1 |
| Rosas-Madrigal, S | 1 |
| Ivette Aparicio-Bautista, D | 1 |
| Reyes-Gordillo, K | 1 |
| Lakshman, MR | 1 |
| Ortiz-Fernández, A | 1 |
| Quezada, H | 1 |
| Medina-Contreras, Ó | 1 |
| Villa-Treviño, S | 1 |
| Isael Pérez-Carreón, J | 1 |
| Arellanes-Robledo, J | 1 |
| Kaltenecker, D | 1 |
| Themanns, M | 1 |
| Mueller, KM | 1 |
| Spirk, K | 1 |
| Golob-Schwarzl, N | 1 |
| Friedbichler, K | 1 |
| Kenner, L | 1 |
| Haybaeck, J | 1 |
| Moriggl, R | 1 |
| Gao, J | 1 |
| Xiong, R | 1 |
| Xiong, D | 1 |
| Zhao, W | 1 |
| Zhang, S | 1 |
| Yin, T | 1 |
| Zhang, X | 1 |
| Jiang, G | 1 |
| Yin, Z | 1 |
| Casagrande, V | 1 |
| Mauriello, A | 1 |
| Anemona, L | 1 |
| Mavilio, M | 1 |
| Iuliani, G | 1 |
| De Angelis, L | 1 |
| D'Onofrio, M | 1 |
| Arisi, I | 1 |
| Federici, M | 2 |
| Menghini, R | 1 |
| Chung, YL | 1 |
| Wu, ML | 1 |
| Kumamoto, R | 1 |
| Uto, H | 1 |
| Oda, K | 1 |
| Ibusuki, R | 1 |
| Tanoue, S | 1 |
| Arima, S | 1 |
| Mawatari, S | 1 |
| Kumagai, K | 1 |
| Numata, M | 1 |
| Tamai, T | 1 |
| Moriuchi, A | 1 |
| Fujita, H | 1 |
| Oketani, M | 1 |
| Ido, A | 1 |
| Tsubouchi, H | 1 |
| Ip, BC | 1 |
| Liu, C | 1 |
| Smith, DE | 1 |
| Ausman, LM | 3 |
| Wang, XD | 3 |
| Umemura, A | 1 |
| Park, EJ | 1 |
| Taniguchi, K | 1 |
| Lee, JH | 1 |
| Shalapour, S | 1 |
| Valasek, MA | 1 |
| Aghajan, M | 1 |
| Nakagawa, H | 1 |
| Seki, E | 1 |
| Hall, MN | 1 |
| Karin, M | 1 |
| Duan, XY | 1 |
| Pan, Q | 1 |
| Yan, SY | 1 |
| Ding, WJ | 1 |
| Fan, JG | 1 |
| Qiao, L | 1 |
| Fang, JZ | 1 |
| Li, C | 1 |
| Liu, XY | 1 |
| Hu, TT | 1 |
| Fan, ZS | 1 |
| Han, ZG | 1 |
| Healy, ME | 1 |
| Lahiri, S | 1 |
| Hargett, SR | 1 |
| Chow, JD | 1 |
| Byrne, FL | 1 |
| Breen, DS | 1 |
| Kenwood, BM | 1 |
| Taddeo, EP | 1 |
| Lackner, C | 1 |
| Caldwell, SH | 1 |
| Hoehn, KL | 1 |
| Xi, R | 1 |
| Wang, LJ | 1 |
| Wang, Y | 2 |
| Greenberg, AS | 2 |
| Russell, RM | 2 |
| Tong, M | 1 |
| Neusner, A | 1 |
| Longato, L | 1 |
| Lawton, M | 1 |
| Wands, JR | 1 |
| de la Monte, SM | 1 |
| Shimizu, M | 1 |
| Yasuda, Y | 1 |
| Sakai, H | 1 |
| Kubota, M | 1 |
| Terakura, D | 1 |
| Baba, A | 1 |
| Ohno, T | 1 |
| Kochi, T | 1 |
| Tsurumi, H | 1 |
| Tanaka, T | 1 |
| Moriwaki, H | 1 |
| Srivastava, J | 1 |
| Siddiq, A | 1 |
| Emdad, L | 1 |
| Santhekadur, PK | 1 |
| Chen, D | 1 |
| Gredler, R | 1 |
| Shen, XN | 1 |
| Robertson, CL | 1 |
| Dumur, CI | 1 |
| Hylemon, PB | 1 |
| Mukhopadhyay, ND | 1 |
| Bhere, D | 1 |
| Shah, K | 1 |
| Ahmad, R | 1 |
| Giashuddin, S | 1 |
| Stafflinger, J | 1 |
| Subler, MA | 1 |
| Windle, JJ | 1 |
| Fisher, PB | 1 |
| Sarkar, D | 1 |
| Rappa, F | 1 |
| Greco, A | 1 |
| Podrini, C | 1 |
| Cappello, F | 1 |
| Bourgoin, L | 1 |
| Peyrou, M | 1 |
| Marino, A | 1 |
| Scibetta, N | 1 |
| Williams, R | 1 |
| Mazzoccoli, G | 1 |
| Pazienza, V | 1 |
| Vinciguerra, M | 1 |
| Iwai, S | 1 |
| Murai, T | 1 |
| Makino, S | 1 |
| Min, W | 1 |
| Morimura, K | 1 |
| Mori, S | 1 |
| Hagihara, A | 1 |
| Seki, S | 1 |
| Fukushima, S | 1 |
| Shimada, A | 1 |
| Shiota, G | 1 |
| Miyata, H | 1 |
| Kamahora, T | 1 |
| Kawasaki, H | 1 |
| Shiraki, K | 1 |
| Hino, S | 1 |
| Terada, T | 1 |
| Glauert, HP | 1 |
| Pitot, HC | 1 |
23 other studies available for diethylnitrosamine and Fatty Liver
| Article | Year |
|---|---|
Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diet, High-Fat; Diethylni | 2021 |
MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Fatt | 2022 |
Nucleoredoxin interaction with flightless-I/actin complex is differentially altered in alcoholic liver disease.
Topics: Animals; Body Weight; Cell Proliferation; Cytochrome P-450 CYP2E1; Diethylnitrosamine; Ethanol; Fatt | 2020 |
STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytokines; Diethylni | 2019 |
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcino | 2018 |
Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Progression; Fatty L | 2019 |
Promyelocytic leukaemia protein links DNA damage response and repair to hepatitis B virus-related hepatocarcinogenesis.
Topics: Adiposity; Animals; Antibiotics, Antineoplastic; Biomarkers; Biopsy; Carcinoma, Hepatocellular; Cell | 2013 |
Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Animals; Biomarkers; Body Weight; Deoxyguanosine; | 2013 |
High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Dietary Carbohydrates; Dietary Fats; Die | 2014 |
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cell T | 2014 |
High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diet, High-Fat; Diet | 2014 |
Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; DNA-Binding Prote | 2015 |
Dietary sugar intake increases liver tumor incidence in female mice.
Topics: Adiposity; Animal Feed; Animals; Body Weight; Carcinogens; Dietary Fats; Dietary Sucrose; Diethylnit | 2016 |
Actein ameliorates hepatobiliary cancer through stemness and p53 signaling regulation.
Topics: AC133 Antigen; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Cell Proliferation; Cyclin D | 2017 |
Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats.
Topics: Animals; Carcinogens; Diet; Dietary Fats; Diethylnitrosamine; Fatty Liver; Glutathione S-Transferase | 2009 |
Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats.
Topics: Animals; Blotting, Western; Carcinogens; Carotenoids; Cell Transformation, Neoplastic; Chromatograph | 2010 |
Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; | 2009 |
Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Apoptosis; bcl-Associated Death Protein; Cocarc | 2011 |
Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Transformat | 2012 |
Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Nucleus; Diet, High-Fat; Diethylnitrosamine; Fa | 2013 |
High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkylating Agents; Animals; Deoxyguanosine; Diethylnitrosamine; Disease | 2007 |
Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Biopsy, Needle; Carcinoma, Hepatocellular; Diethylnitros | 1998 |
Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats.
Topics: Analysis of Variance; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Diethylnitrosamine; Fatt | 1986 |