diethylnitrosamine has been researched along with Experimental Neoplasms in 276 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study was envisaged to investigate the possible synergistic effect of combined treatment of curcumin with piperine in suppression of diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats, owing to permeability enhancing effect of latter." | 7.81 | Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. ( Padwad, YS; Patial, V; Pratap, K; S, M; Sharma, S; Singh, D, 2015) |
| " In the present study, we investigated the antiproliferative effect of gallic acid during diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in male wistar albino rats." | 7.74 | Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma. ( Anandakumar, P; Devaki, T; Jagan, S; Kamaraj, S; Ramakrishnan, G, 2008) |
| "Female Syrian hamsters were given a single sc dose of 45 mg diethylnitrosamine (DEN)/kg body weight on 1 of the 15 days of pregnancy." | 7.65 | Transplacental effects of diethylnitrosamine in Syrian hamsters as related to different days of administration during pregnancy. ( Hilfrich, J; Mohr, U; Reznik, G; Reznik-Schüller, H, 1975) |
| "The effects of treatments with diethylnitrosamine (DENA) and hepatitis B virus (HBV) on macaque monkeys were investigated by virus serology and by light and electron microscopy." | 7.65 | Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus. ( Cabral, GA; Gyorkey, F; Gyorkey, P; Hollinger, FB; Melnick, JL; Mirkovic, R, 1977) |
| "Hepatocellular carcinoma is one of the most common cancers and lethal diseases in the world." | 5.38 | Myrtenal, a natural monoterpene, down-regulates TNF-α expression and suppresses carcinogen-induced hepatocellular carcinoma in rats. ( Babu, LH; Balasubramanian, MP; Perumal, S, 2012) |
| " Here, we investigated the effects of maternal diets differing in protein source on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in adult rat offspring." | 3.96 | Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring. ( Choi, J; Kwon, YH; Won, SB, 2020) |
| " The present study was envisaged to investigate the possible synergistic effect of combined treatment of curcumin with piperine in suppression of diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats, owing to permeability enhancing effect of latter." | 3.81 | Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. ( Padwad, YS; Patial, V; Pratap, K; S, M; Sharma, S; Singh, D, 2015) |
| "In this study, we explored whether treatment with FGF-21 could prevent diethylnitrosamine (DEN) induced hepatocarcinogenesis in mice." | 3.81 | Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice. ( Li, D; Liu, M; Liu, Z; Rasoul, LM; Ren, G; Wang, W; Wu, Q; Xu, P; Ye, X; Yuan, Q; Zhang, Y, 2015) |
| " In the present study, we investigated the antiproliferative effect of gallic acid during diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in male wistar albino rats." | 3.74 | Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma. ( Anandakumar, P; Devaki, T; Jagan, S; Kamaraj, S; Ramakrishnan, G, 2008) |
| "The effects of diethylnitrosamine (DEN) and vinylethylnitrosamine (VEN) in the F1 generation of Syrian golden hamsters are described after the compounds were administered to the P generation during the second half of pregnancy." | 3.66 | Assessment of nitrosamine transplacental carcinogenesis in the Syrian golden hamster. ( Althoff, J; Emura, M; Michiels, F; Mohr, U; Richter-Reichhelm, HB; Schmidt-Riese, L; Tsuda, H, 1983) |
| "Female Syrian hamsters were given a single sc dose of 45 mg diethylnitrosamine (DEN)/kg body weight on 1 of the 15 days of pregnancy." | 3.65 | Transplacental effects of diethylnitrosamine in Syrian hamsters as related to different days of administration during pregnancy. ( Hilfrich, J; Mohr, U; Reznik, G; Reznik-Schüller, H, 1975) |
| "Carcinomas developed in the mucosa of the esophagus in BUF strain rats ingesting diethylnitrosamine in the diet." | 3.65 | Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine. ( Reuber, MD, 1977) |
| "The effects of treatments with diethylnitrosamine (DENA) and hepatitis B virus (HBV) on macaque monkeys were investigated by virus serology and by light and electron microscopy." | 3.65 | Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus. ( Cabral, GA; Gyorkey, F; Gyorkey, P; Hollinger, FB; Melnick, JL; Mirkovic, R, 1977) |
| "05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
| "Liver neoplasms were induced in medakas (Oryzias latipes) by the addition of diethylnitrosamine (DENA) to their aquarium water at levels of 15-135 ppm for 8 weeks." | 3.65 | Histologic and electron microscopy observations on diethylnitrosamine-induced hepatomas in small aquarium fish (Oryzias latipes). ( Ishikawa, T; Shimamine, T; Takayama, S, 1975) |
| "The characteristic clostridial growth which is testable, after systemic administration of tetanus spores, as a positive tumour tetanus - correlation, was manifested by a highly selective tetanus lethality of rats with progressive hepatomas following induction with dimethylaminoazobenzene and diethylnitrosamine, respectively, as well as with methylcholanthren-induced fibrosarcomas of the rat." | 3.65 | [The tumor-tetanus assay--experimental studies on the biological differentiation between carcinogenesis and organ regeneration of the rat (author's transl)]. ( Fabricius, EA; Schneeweiss, U, 1975) |
| "Administration of 40 ppm diethylnitrosamine (DENA) in the drinking water for 10 weeks to male Fischer rats led to hepatocellular carcinoma in 100 percent with metastasis to the lung in 40 percent, of the animals living for the full experimental period of 20 weeks." | 3.65 | Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression. ( Madison, RM; Viguera, C; Ward, JM; Weisburger, EK; Weisburger, JH, 1975) |
| " The non-toxic dosage of eugenol was shown to enhance apoptosis, simultaneously suppressing cell proliferation in the lung tissue of carcinogen-treated mice without affecting the normal mice." | 1.62 | Eugenol emerges as an elixir by targeting β-catenin, the central cancer stem cell regulator in lung carcinogenesis: an ( Barua, A; Bhattacharyya, M; Choudhury, P; Pattanayak, R; Roy, A; Saha, P, 2021) |
| "Animal carcinogenesis models induced by environmental chemicals have been widely used for basic and applied cancer research." | 1.56 | An organoid-based carcinogenesis model induced by in vitro chemical treatment. ( Hippo, Y; Imai, T; Maru, Y; Masui, R; Naruse, M; Ochiai, M, 2020) |
| "Treatment with crocin-coated MNPs was associated with regression of precancerous lesions, significant upregulation of apoptotic cells and downregulation of Bcl-2 labeling and markers of cell proliferation, inflammation, oxidative stress and angiogenesis." | 1.46 | Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles. ( Amin, A; El-Kharrag, R; Greish, Y; Hisaindee, S; Karam, SM, 2017) |
| "Lung cancer is the foremost cause of cancer mortality and a growing economic burden worldwide." | 1.46 | Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins. ( Gao, W; Li, J; Liu, J; Liu, Z; Ma, L; Man, S; Qiu, P, 2017) |
| "Real-time analyses of hepatocellular carcinoma were performed in living mice to assess the applicability of probe electrospray ionization-mass spectrometry (PESI-MS) in medical diagnosis." | 1.39 | Real-time diagnosis of chemically induced hepatocellular carcinoma using a novel mass spectrometry-based technique. ( Chen, LC; Fujii, H; Hara, M; Hiraoka, K; Mandal, MK; Takeda, S; Tanabe, K; Yoshimura, K, 2013) |
| "We propose a novel mechanism for aneuploidy generation that involves impaired telomere replication upon loss of cohesin-SA1, with clear implications in tumourigenesis." | 1.38 | Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. ( Blasco, MA; Cañamero, M; Carretero, M; Cuadrado, A; Drosopoulos, WC; Losada, A; Martínez, P; Remeseiro, S; Schildkraut, CL, 2012) |
| "Hepatocellular carcinoma is one of the most common cancers and lethal diseases in the world." | 1.38 | Myrtenal, a natural monoterpene, down-regulates TNF-α expression and suppresses carcinogen-induced hepatocellular carcinoma in rats. ( Babu, LH; Balasubramanian, MP; Perumal, S, 2012) |
| " We conclude that long-term intake of TRF could reduce cancer risk by preventing hepatic lipid peroxidation and protein oxidation damage due to its antioxidant actions." | 1.32 | Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil. ( Beg, ZH; Iqbal, J; Minhajuddin, M, 2004) |
| " Polyen antibiotics combined with DMSO also demonstrated antineoplastic activity at the animals treated with carcinogenic agent--diethyl nitrosoamine (DENA)." | 1.31 | [Radioprotective and antineoplastic activity of polyene antibiotics combined with dimethyl sulfoxide]. ( Aliev, DI; Ibragimova, VKh, 2002) |
| "d-Limonene treatment alone caused a significant increase in the number of atypical tubules and atypical hyperplasias in F344 rats when compared with the F344 vehicle control." | 1.28 | The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. ( Dietrich, DR; Swenberg, JA, 1991) |
| " Strain variations among male mice were studied in terms of the number of days of survival with chronic administration of N-nitroso-diethylamine (NDEA)." | 1.28 | Mouse and rat strain variations in sensitivity to N-nitroso-diethylamine, hereditary transmission of the trait and the effect of 3-tert-butyl-4-hydroxyanisole on sensitivity. ( Horie, S; Ohbu, M; Okudaira, M, 1992) |
| "Antipyrine oxidation was increased in the cancerous state but the urinary metabolic profiles were similar in rats with cancer and in controls." | 1.28 | Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital. ( Aitio, ML; Arvela, P; Bartsch, H; Béréziat, JC; Hietanen, E, 1992) |
| "Groups of rats, either dosed with N-nitrosodiethylamine (NDEA) for 10 weeks (from the age of 7 to 17 weeks) or untreated, were fed diets containing either 2% (low fat, LF) or 30% polyunsaturated fat (high fat, HF) on an equicaloric basis from 5 weeks until rats were 43 weeks old." | 1.28 | Mechanisms of fat-related modulation of N-nitrosodiethylamine-induced tumors in rats: organ distribution, blood lipids, enzymes and pro-oxidant state. ( Ahotupa, M; Bartsch, H; Béréziat, JC; Bussacchini-Griot, V; Cabral, JR; Camus, AM; Hietanen, E; Laitinen, M; Wild, H, 1991) |
| "The R16 males developed liver cancer and the R16 females developed breast cancer, there also were malignancies in other organs in some animals." | 1.28 | Genetic control of susceptibility to diethylnitrosamine and dimethylbenzanthracene carcinogenesis in rats. ( Gill, TJ; Kunz, HW; Melhem, MF, 1991) |
| " The second step is evaluation of the independent dose-response relationships observed in animals and prediction of human risk distributions by normalizing time units with respect to species natural life span." | 1.28 | Scaling of fatal cancer risks from laboratory animals to man. ( Raabe, OG, 1989) |
| " For extrapolation of test results from animals to humans, knowledge of the carcinogenic potency, the dose-response relationship, and the toxicokinetic behavior of the test chemical is essential." | 1.27 | Predictability of human carcinogenicity from animal studies. ( Dybing, E, 1986) |
| " These results indicate that, when administered by this route, NDEA is a much more potent carcinogen in the respiratory tract than is NDMA but NDMA alone seems to be carcinogenic to the liver, at a total dosage of 1." | 1.27 | A comparison of the carcinogenicity of N-nitrosodiethylamine and N-nitrosodimethylamine after intratracheal instillation into Syrian golden hamsters. ( Hirata, M; Hisanaga, A; Inamasu, T; Ishinishi, N; Tanaka, A, 1988) |
| " The dose levels in the individual dose-response experiments ranged from the lowest concentrations of previous experiments (NDEA, 0." | 1.27 | Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats. ( Berger, MR; Schmähl, D; Zerban, H, 1987) |
| "Triethanolamine was dissolved in distilled water at levels of 0 (control), 1, and 2%, and groups of 50 males and 50 females were given these doses ad libitum as drinking water for 2 yr." | 1.27 | Lack of carcinogenicity of triethanolamine in F344 rats. ( Furuta, K; Hayashi, Y; Kanno, J; Maekawa, A; Matsuoka, C; Ogiu, T; Onodera, H; Tanigawa, H, 1986) |
| "Two animals had metastases in the lung as well as one renal carcinoma and one tumor in the hemisphere of the brain." | 1.26 | Hepatocarcinogenetic effect of DENA in pigs. ( Berg, H; Graw, JJ, 1977) |
| " This range of dosage corresponds to approximately 2-1,080 microgram/kg b." | 1.26 | Carcinogenic dose-related response to nitrosamines. ( Crampton, RF, 1980) |
| "The pulmonary metastases were first detected in mice dying between 51 and 60 weeks of age (5%)." | 1.26 | Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice. ( Mihailovich, N; Rao, KV; Vesselinovitch, SD, 1978) |
| "After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50)." | 1.26 | [Comparative investigations on the organotropic carcinogenic effect of different N-nitroso compounds with rat after single and chronic treatment (author's transl)]. ( Kouros, M; Manncke, K; Schweinsberg, F, 1979) |
| "In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers." | 1.26 | Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice. ( McGuire, LJ; Poound, AW, 1978) |
| "A dose-response study was conducted in Fischer rats with nitrosodiethylamine, which was administered in regulated amounts as a solution in drinking water." | 1.26 | Dose response studies of carcinogenesis in rats by nitrosodiethylamine. ( Lijinsky, W; Reuber, MD; Riggs, CW, 1981) |
| " However, the hibernating females of the low dosage group developed fewer lung tumors." | 1.26 | Carcinogenicity of N-nitrosodiethylamine in hibernating and nonhibernating European hamsters. ( Mohr, U; Reznik, G; Reznik-Schüller, R, 1977) |
| " It was pointed out that the direct measurement of the dose-response relation (l(d) approximately dm) yields only the number of hits contributed by the carcinogen applied anose rate is low or very low, the contribution of background process becomes significant, and these hits contribute to the power of time, r, of the incidence-time relation." | 1.26 | Multi-hit kinetics of tumor formation, with special reference to experimental liver and human lung carcinogenesis and some gneral conclusions. ( Emmelot, P; Scherer, E, 1977) |
| " The clearing method was used successfully to discern differences in tumor incidence in a dose-response study with diethylnitrosamine." | 1.26 | A method for rapid scoring of respiratory tumors in hamsters. ( Dalbey, WE, 1980) |
| "Transplantable hepatomas varied in their fibronectin staining from fibronectin-negative hepatomas to ones with fibronectin staining within or around every tumor cell." | 1.26 | Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas. ( Ruoslahti, E; Sell, S, 1982) |
| " DMN induced a considerable quantity of liver tumours, the highest incidence being demonstrated in the lowest dosage group." | 1.26 | Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine. ( Kmoch, N; Mohr, U; Reznik, G, 1976) |
| " Dose-response relationships measured with diethylnitrosamine, the carcinogen with the lowest toxicity as compared with the carcinogenic action, indicated that island formation is due to a one-hit process, i." | 1.26 | Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis. ( Emmelot, P; Scherer, E, 1976) |
| " DENA, which was administered to 38 rats in a dosage of 20 mg/kg/week, induced liver tumors in 90% of the animals; in 29% besides some precancerous stages predominantly malignant carcinomas of the oesophagus were seen." | 1.26 | Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats. ( Diehl, B; Habs, M; Krüger, FW; Schmähl, D, 1976) |
| "Methionine was contained in both the amino acid and the lipotrope supplement and probably was responsible for reducing hepatocarcinoma incidence." | 1.26 | Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet. ( Rogers, AE, 1977) |
| "A new model of liver cancer development with chemicals is described." | 1.26 | Some conclusions derived from a liver model for carcinogenesis. ( Cameron, R; Farber, E, 1981) |
| "The total cobalamin content of the hepatomas was significantly lower than that of host or control livers." | 1.26 | Altered cobalamin distribution in rat hepatomas and in the livers of rats treated with diethylnitrosamine. ( Linnell, JC; Matthews, DM; Morris, HP; Poirier, LA; Quadros, EV, 1977) |
| "induced tumors of liver (hepatocellular cancers and adenomas), and of hematopoietic system (hemocytoblastosis)." | 1.26 | The induction of tumors in Rana temporaria with nitrosamines. ( Khudoley, VV, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 217 (78.62) | 18.7374 |
| 1990's | 22 (7.97) | 18.2507 |
| 2000's | 17 (6.16) | 29.6817 |
| 2010's | 15 (5.43) | 24.3611 |
| 2020's | 5 (1.81) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, H | 1 |
| Liu, X | 1 |
| Jin, L | 1 |
| Lang, J | 1 |
| Hu, Z | 1 |
| Mao, W | 1 |
| Cheng, C | 1 |
| Shou, Q | 1 |
| Li, X | 2 |
| Yu, H | 1 |
| Gong, Y | 1 |
| Wu, P | 1 |
| Feng, Q | 1 |
| Liu, C | 1 |
| Naruse, M | 1 |
| Masui, R | 1 |
| Ochiai, M | 1 |
| Maru, Y | 1 |
| Hippo, Y | 1 |
| Imai, T | 1 |
| Choi, J | 1 |
| Won, SB | 1 |
| Kwon, YH | 1 |
| Choudhury, P | 1 |
| Barua, A | 1 |
| Roy, A | 1 |
| Pattanayak, R | 1 |
| Bhattacharyya, M | 1 |
| Saha, P | 1 |
| Ferrara-Romeo, I | 1 |
| Martínez, P | 2 |
| Blasco, MA | 2 |
| Yang, F | 1 |
| Li, J | 2 |
| Deng, H | 1 |
| Wang, Y | 1 |
| Lei, C | 1 |
| Wang, Q | 1 |
| Xiang, J | 1 |
| Liang, L | 1 |
| Xia, J | 1 |
| Pan, X | 1 |
| Long, Q | 1 |
| Chang, L | 1 |
| Xu, P | 2 |
| Huang, A | 1 |
| Wang, K | 1 |
| Tang, N | 1 |
| Yoshimura, K | 1 |
| Mandal, MK | 1 |
| Hara, M | 1 |
| Fujii, H | 1 |
| Chen, LC | 1 |
| Tanabe, K | 1 |
| Hiraoka, K | 1 |
| Takeda, S | 1 |
| Mukhopadhyay, B | 1 |
| Schuebel, K | 1 |
| Mukhopadhyay, P | 1 |
| Cinar, R | 1 |
| Godlewski, G | 1 |
| Xiong, K | 1 |
| Mackie, K | 1 |
| Lizak, M | 1 |
| Yuan, Q | 2 |
| Goldman, D | 1 |
| Kunos, G | 1 |
| Zhang, Y | 1 |
| Wang, W | 1 |
| Liu, Z | 2 |
| Rasoul, LM | 1 |
| Wu, Q | 1 |
| Liu, M | 1 |
| Ye, X | 1 |
| Li, D | 1 |
| Ren, G | 1 |
| Patial, V | 1 |
| S, M | 1 |
| Sharma, S | 1 |
| Pratap, K | 1 |
| Singh, D | 1 |
| Padwad, YS | 1 |
| Mercer, KE | 1 |
| Pulliam, C | 1 |
| Hennings, L | 1 |
| Lai, K | 1 |
| Cleves, M | 1 |
| Jones, E | 1 |
| Drake, RR | 1 |
| Ronis, M | 1 |
| Umemura, A | 1 |
| He, F | 1 |
| Taniguchi, K | 1 |
| Nakagawa, H | 1 |
| Yamachika, S | 1 |
| Font-Burgada, J | 1 |
| Zhong, Z | 1 |
| Subramaniam, S | 1 |
| Raghunandan, S | 1 |
| Duran, A | 1 |
| Linares, JF | 1 |
| Reina-Campos, M | 1 |
| Umemura, S | 1 |
| Valasek, MA | 1 |
| Seki, E | 1 |
| Yamaguchi, K | 1 |
| Koike, K | 1 |
| Itoh, Y | 1 |
| Diaz-Meco, MT | 1 |
| Moscat, J | 1 |
| Karin, M | 1 |
| El-Kharrag, R | 1 |
| Amin, A | 1 |
| Hisaindee, S | 1 |
| Greish, Y | 1 |
| Karam, SM | 1 |
| Man, S | 1 |
| Qiu, P | 1 |
| Liu, J | 1 |
| Ma, L | 1 |
| Gao, W | 1 |
| Jagan, S | 1 |
| Ramakrishnan, G | 1 |
| Anandakumar, P | 1 |
| Kamaraj, S | 1 |
| Devaki, T | 1 |
| Piskunova, TS | 1 |
| Zabezhinskiĭ, MA | 4 |
| Popovich, IG | 1 |
| Tyndyk, ML | 1 |
| Iurova, MN | 1 |
| Anisimov, VN | 1 |
| Kaledin, VI | 1 |
| Il'nitskaia, SI | 1 |
| Baginskaia, NV | 1 |
| Ellis, JM | 1 |
| Paul, DS | 1 |
| Depetrillo, MA | 1 |
| Singh, BP | 1 |
| Malarkey, DE | 1 |
| Coleman, RA | 1 |
| Remeseiro, S | 1 |
| Cuadrado, A | 1 |
| Carretero, M | 1 |
| Drosopoulos, WC | 1 |
| Cañamero, M | 1 |
| Schildkraut, CL | 1 |
| Losada, A | 1 |
| Vargas-Olvera, CY | 1 |
| Sánchez-González, DJ | 1 |
| Solano, JD | 1 |
| Aguilar-Alonso, FA | 1 |
| Montalvo-Muñoz, F | 1 |
| Martínez-Martínez, CM | 1 |
| Medina-Campos, ON | 1 |
| Ibarra-Rubio, ME | 1 |
| Babu, LH | 1 |
| Perumal, S | 1 |
| Balasubramanian, MP | 1 |
| Thirunavukkarasu, C | 1 |
| Prince Vijeya Singh, J | 1 |
| Thangavel, M | 1 |
| Selvendiran, K | 1 |
| Sakthisekaran, D | 1 |
| Ekuni, A | 1 |
| Miyoshi, E | 1 |
| Ko, JH | 1 |
| Noda, K | 1 |
| Kitada, T | 1 |
| Ihara, S | 1 |
| Endo, T | 1 |
| Hino, A | 1 |
| Honke, K | 1 |
| Taniguchi, N | 1 |
| Yamagishi, M | 1 |
| Natsume, M | 1 |
| Osakabe, N | 1 |
| Okazaki, K | 1 |
| Furukawa, F | 1 |
| Imazawa, T | 1 |
| Nishikawa, A | 1 |
| Hirose, M | 8 |
| Ibragimova, VKh | 1 |
| Aliev, DI | 1 |
| DONTENWILL, W | 2 |
| MOHR, U | 9 |
| ZAGEL, M | 1 |
| SCHMAHL, D | 10 |
| THOMAS, C | 2 |
| KONIG, K | 1 |
| ARGUS, MF | 2 |
| HOCH-LIGETI, C | 1 |
| COTE, J | 1 |
| OEHLERT, W | 1 |
| BUECHNER, F | 1 |
| REID, JD | 1 |
| RILEY, JF | 1 |
| SHEPHERD, DM | 1 |
| HERROLD, KM | 2 |
| HEISE, E | 1 |
| GOERLICH, M | 1 |
| SYDOW, G | 1 |
| DRUCKREY, H | 1 |
| SCHILDBACH, A | 1 |
| SCHMAEHL, D | 2 |
| PREUSSMANN, R | 4 |
| IVANKOVIC, S | 2 |
| RAPP, HJ | 2 |
| CARLETON, JH | 1 |
| CRISLER, C | 1 |
| NADEL, EM | 1 |
| WIEBECKE, B | 1 |
| FEL, VIa | 1 |
| TSIKARISHVILI, TN | 1 |
| SHVEMBERGER, IN | 1 |
| SCHELD, G | 1 |
| Doi, K | 1 |
| Wanibuchi, H | 2 |
| Salim, EI | 2 |
| Shen, J | 1 |
| Wei, M | 1 |
| Mitsuhashi, M | 1 |
| Kudoh, S | 1 |
| Hirata, K | 1 |
| Fukushima, S | 7 |
| Wycherly, BJ | 1 |
| Moak, MA | 1 |
| Christensen, MJ | 1 |
| Iqbal, J | 1 |
| Minhajuddin, M | 1 |
| Beg, ZH | 1 |
| Mizgireuv, IV | 1 |
| Revskoy, SY | 1 |
| Kitagawa, T | 1 |
| Watanabe, R | 1 |
| Sugano, H | 1 |
| Yager, JD | 1 |
| Yager, R | 1 |
| Peraino, C | 1 |
| Staffeldt, EF | 1 |
| Ludeman, VA | 1 |
| Kojima, S | 1 |
| Hama, Y | 1 |
| Kubodera, A | 1 |
| Williams, GM | 1 |
| Katayama, S | 1 |
| Ohmori, T | 1 |
| Labuc, GE | 1 |
| Archer, MC | 2 |
| Stout, DL | 1 |
| Becker, FF | 2 |
| Leonard, TB | 1 |
| Dent, JG | 1 |
| Graichen, ME | 1 |
| Lyght, O | 1 |
| Popp, JA | 2 |
| Gurkalo, VK | 5 |
| Zabezhinski, MA | 1 |
| Jensen, RK | 1 |
| Sleight, SD | 1 |
| Goodman, JI | 1 |
| Aust, SD | 1 |
| Trosko, JE | 1 |
| Gould, VE | 1 |
| Linnoila, RI | 1 |
| Memoli, VA | 1 |
| Warren, WH | 1 |
| Koen, H | 1 |
| Pugh, TD | 1 |
| Nychka, D | 1 |
| Goldfarb, S | 2 |
| Li, S | 1 |
| Fan, MC | 1 |
| Li, SS | 1 |
| Liu, Y | 1 |
| Wang, MS | 1 |
| Deml, E | 1 |
| Oesterle, D | 1 |
| Curtin, NJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU)[NCT00978250] | Phase 2 | 95 participants (Actual) | Interventional | 2009-08-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Here is the count of participants with serious and non-serious adverse events assessed by the Common Terminology Criteria in Adverse Events (CTCAE v4.0). A non-serious adverse event is any untoward medical occurrence. A serious adverse event is an adverse event or suspected adverse reaction that results in death, a life threatening adverse drug experience, hospitalization, disruption of the ability to conduct normal life functions, congenital anomaly/birth defect or important medical events that jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the previous outcomes mentioned. (NCT00978250)
Timeframe: Date treatment consent signed to date off study, approximately 109 months and 16 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| 5-Fluro-2'-Deoxycytidine (FdCyd) + Tetrahydrouridine (THU) | 91 |
Response was measured using the Response Evaluation Criteria in Solid Tumors (RECIST). Complete response is disappearance of all target lesions. Partial response is at least a 30% decrease in the sum of the longest diameter (LD) of target lesions, taking as reference the baseline sum of the LD. (NCT00978250)
Timeframe: until subject progressed or went off study for other reasons (up to approximately 1 year)
| Intervention | percentage of participants (Number) |
|---|---|
| Non-Small Cell Cancer Stratum | 0.0 |
| Breast Cancer Stratum | 6.9 |
| Bladder Cancer Stratum | 5.6 |
| Head and Neck Cancer Stratum | 0.0 |
Progression-free survival (PFS) is defined as the time interval from start of treatment to documented evidence of disease progression. Disease progression was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) and is at least a 20% increase in the sum of the longest diameter (LD) of target lesions, taking as reference the smallest sum of the LD recorded since the treatment started or the appearance of one or more new lesions. (NCT00978250)
Timeframe: until subject progressed or went off study for other reasons (up to approximately 1 year)
| Intervention | months (Median) |
|---|---|
| Non-Small Cell Cancer Stratum | 2.3 |
| Breast Cancer Stratum | 3.7 |
| Bladder Cancer Stratum | 3.6 |
| Heand and Neck Cancer Stratum | 1.7 |
10 reviews available for diethylnitrosamine and Experimental Neoplasms
| Article | Year |
|---|---|
Neuroendocrine cells and neuroendocrine neoplasms of the lung.
Topics: Adenocarcinoma; Animals; APUD Cells; Bronchi; Carcinoma, Adenoid Cystic; Carcinoma, Small Cell; Cric | 1983 |
Properties of incomplete carcinogens and promoters in hepatocarcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Hepate | 1982 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
Chemically induced carcinogenesis: a comparison of 1-methyl-1-nitrosourea, 7,12-dimethylbenzanthracene,diethylnitroso-amine and azoxymethan models (minireview).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azoxymethane; Carcinogens; Diethylnitrosamine; Methylnitr | 2001 |
Sequential morphologic alterations in the bronchial epithelium of Syrian golden hamsters during N-nitrosomorpholine-induced pulmonary tumorigenesis.
Topics: Animals; APUD Cells; Bronchi; Cricetinae; Diethylnitrosamine; Epithelium; Inclusion Bodies; Lung Neo | 1977 |
On the participation of cytochrome P-450 in the mechanism of prevention of hepatic carcinogenesis.
Topics: Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Electron Spin Resonance Spectroscopy; L | 1976 |
Experimental carcinogenesis in small aquarium fishes.
Topics: 2-Acetylaminofluorene; Adenoma; Adenoma, Bile Duct; Aflatoxins; Animals; Benzopyrenes; Carcinogens; | 1976 |
Experimental data concerning the question of the synergic action of the influenza virus and of some chemical carcinogens in the pathogenesis of lung cancer.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Humans; Influenza, Human; Lung Neoplasms | 1979 |
Model studies in tobacco carcinogenesis with the Syrian golden hamster.
Topics: Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; Disease Models, | 1979 |
Cell membrane associated antigens in chemical carcinogenesis.
Topics: Amines; Animals; Antigens; Antigens, Neoplasm; Azo Compounds; Cell Membrane; Diethylnitrosamine; Emb | 1976 |
266 other studies available for diethylnitrosamine and Experimental Neoplasms
| Article | Year |
|---|---|
Safflower yellow reduces DEN-induced hepatocellular carcinoma by enhancing liver immune infiltration through promotion of collagen degradation and modulation of gut microbiota.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chalcone; Collagen; Diethylnitrosamine; Gastro | 2021 |
Fuzheng Xiaozheng prescription relieves rat hepatocellular carcinoma through improving anti-inflammation capacity and regulating lipid related metabolisms.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Drugs, Chinese Herbal | 2022 |
An organoid-based carcinogenesis model induced by in vitro chemical treatment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acrylamide; Animals; Carcinogenesis; Carcinogens; Diethylnitrosami | 2020 |
Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Caseins; Diet, Vegetarian; Diethylnitrosamine; F | 2020 |
Eugenol emerges as an elixir by targeting β-catenin, the central cancer stem cell regulator in lung carcinogenesis: an
Topics: A549 Cells; Animals; Apoptosis; beta Catenin; Diethylnitrosamine; Eugenol; Female; Gene Expression R | 2021 |
Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice.
Topics: Age of Onset; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Female; Hi | 2018 |
GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; Down-R | 2019 |
Real-time diagnosis of chemically induced hepatocellular carcinoma using a novel mass spectrometry-based technique.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Liver Neoplasms; Male; Mice; Mice, I | 2013 |
Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progression; Endocannabinoids; Forkh | 2015 |
Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice.
Topics: Animals; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolif | 2015 |
Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzodioxoles; Carcin | 2015 |
Soy Protein Isolate Protects Against Ethanol-Mediated Tumor Progression in Diethylnitrosamine-Treated Male Mice.
Topics: Adenoma; Alkylating Agents; Animals; Blotting, Western; Carcinoma, Hepatocellular; Diet; Diethylnitr | 2016 |
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Survival; Diethylnitrosamine; Gene Expression Regulation, N | 2016 |
Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles.
Topics: Animals; Carcinoma, Hepatocellular; Carotenoids; Cell Proliferation; Diethylnitrosamine; Drug Delive | 2017 |
Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Diethylnitrosamine; ErbB | 2017 |
Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Antioxidants; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; | 2008 |
[Diethylnitrosamine-induced carcinogenesis in PARP-1(-/-) and PARP-1(+/+) mice].
Topics: Animals; Carcinogens; Cholangiocarcinoma; Diethylnitrosamine; DNA Repair; Female; Hemangiosarcoma; I | 2009 |
[O-aminoazotoluene inhibits DENA-induced hepatocarcinogenesis when used together in mice].
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Drug Administration Schedule; Liv | 2010 |
Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Genetic Predisposition to Disease; Glycerol-3-Phosp | 2012 |
Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.
Topics: Aneuploidy; Animals; Carcinogens; Cell Cycle Proteins; Cell Line; Chromatids; Chromosomal Proteins, | 2012 |
Characterization of N-diethylnitrosamine-initiated and ferric nitrilotriacetate-promoted renal cell carcinoma experimental model and effect of a tamarind seed extract against acute nephrotoxicity and carcinogenesis.
Topics: Animals; Carcinogens; Carcinoma, Renal Cell; Cell Transformation, Neoplastic; Diethylnitrosamine; Di | 2012 |
Myrtenal, a natural monoterpene, down-regulates TNF-α expression and suppresses carcinogen-induced hepatocellular carcinoma in rats.
Topics: Animals; Bicyclic Monoterpenes; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Exp | 2012 |
Dietary influence of selenium on the incidence of N-nitrosodiethylamine-induced hepatoma with reference to drug and glutathione metabolizing enzymes.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepatocell | 2002 |
A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III (GnT-III) transgenic mice induced by diethylnitrosamine (DEN): identification of haptoglobin as a target molecule of GnT-III.
Topics: Animals; Carbohydrate Sequence; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Electrop | 2002 |
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anthocyanins; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; | 2003 |
[Radioprotective and antineoplastic activity of polyene antibiotics combined with dimethyl sulfoxide].
Topics: Amphotericin B; Animals; Anti-Bacterial Agents; Candicidin; Diethylnitrosamine; Dimethyl Sulfoxide; | 2002 |
[On the different effect in lung carcinoma of diethylnitrosamine in hamsters and rats].
Topics: Animals; Diethylnitrosamine; Liver Neoplasms; Lung Neoplasms; Neoplasms, Experimental; Rats | 1962 |
[Experimental studies on "syncarcinogenesis". 1. Experiments on cancer induction in rats with simultaneous application of diethylnitrosamine and 4-dimethylaminoazobenzene].
Topics: Animals; Diethylnitrosamine; Neoplasms; Neoplasms, Experimental; Nitroso Compounds; p-Dimethylaminoa | 1963 |
Induction of malignant tumors in the guinea pig by oral administration of diethylnitrosamine.
Topics: Administration, Oral; Diethylnitrosamine; Guinea Pigs; Liver Neoplasms; Lung Neoplasms; Neoplasms; N | 1963 |
[Autoradiographic studies on DNA synthesis during experimental cancerization of liver parenchyma cells in rats after diethylnitrosamine].
Topics: Animals; Autoradiography; Diethylnitrosamine; DNA; DNA Replication; DNA, Neoplasm; Liver Neoplasms; | 1962 |
HISTOLOGICAL AND ENZYMATIC CHANGES IN THE LIVERS OF RATS FED THE HEPATIC CARCINOGEN DIETHYLNITROSAMINE.
Topics: Carboxy-Lyases; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dopa Decarboxylase; Hist | 1963 |
INDUCTION OF OLFACTORY NEUROEPITHELIAL TUMORS IN SYRIAN HAMSTERS BY DIETHYLNITROSAMINE.
Topics: Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Histology; Mesocricetus; Neoplasms; Neoplasms, | 1964 |
[CHANGES IN METABOLIC PARAMETERS AND GLYCOLYTIC ENZYME ACTIVITIES DURING THE CANCERIZATION OF RAT LIVERS BY DIETHYLNITROSAMINE].
Topics: Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose-6-Phosp | 1964 |
[THE HEXOKINASE ACTIVITY IN THE MITOCHONDRIA OF THE PRECANCEROUS RAT LIVER AND TRANSPLANTED DIETHYLNITROSAMINE HEPATOMA].
Topics: Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; | 1964 |
[QUANTITATIVE ANALYSIS OF THE CARCINOGENIC EFFECT OF DIETHYLNITROSAMINE].
Topics: Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA; DNA, Neoplasm; Esophageal Neoplasms | 1963 |
EFFECT OF ROUTE OF ADMINISTRATION ON THE CARCINOGENIC ACTION OF DIETHYLNITROSAMINE (N-NITROSODIETHYLAMINE).
Topics: Animals; Bronchial Neoplasms; Carcinogens; Cricetinae; Diethylnitrosamine; Female; Humans; Injection | 1964 |
INDUCTION OF MALIGNANT TUMORS IN THE RABBIT BY ORAL ADMINISTRATION OF DIETHYLNITROSAMINE.
Topics: Administration, Oral; Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Lung Neoplasms; Neo | 1965 |
[AUTORADIOGRAPHIC STUDIES DURING EXPERIMENTAL CARCINOGENESIS IN THE RESPIRATORY TRACT OF THE HAMSTER AFTER TREATMENT WITH DIETHYLNITROSAMINE].
Topics: Animals; Autoradiography; Carcinogenesis; Cricetinae; Diethylnitrosamine; Neoplasms; Neoplasms, Expe | 1964 |
[ON ANTIGENIC CHARACTERISTICS OF HEPATOMAS PRODUCED IN RATS WITH N-NITROSODIETHYLAMINE].
Topics: Antigens; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethylamines; Liver Neoplasms; Neoplasms; Ne | 1964 |
[THE TOXIC AND CARCINOGENIC EFFECTS OF DIETHYLNITROSAMINE IN RATS DURING SIMULTANEOUS TREATMENT WITH A LIVER PROTECTIVE AGENT].
Topics: Amino Acids; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Neoplasms; Neoplasms, Experimental; N | 1964 |
Revised rat multi-organ carcinogenesis bioassay for whole-body detection of chemopreventive agents: modifying potential of S-methylcysteine.
Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Biological Assay; Carcinogens; Chemoprevention; C | 2004 |
High dietary intake of sodium selenite induces oxidative DNA damage in rat liver.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Analysis of Variance; Animals; Carcinogens; Deoxyguanosine; Dietary Sup | 2004 |
Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Anticholesteremic Agents; Antioxidants; Carcinoge | 2004 |
Transplantable tumor lines generated in clonal zebrafish.
Topics: Animals; Cell Line, Tumor; Diethylnitrosamine; Diploidy; Disease Models, Animal; Homozygote; Humans; | 2006 |
Induction of gamma-glutamyl transpeptidase activity by dietary phenobarbital in "spontaneous" hepatic tumors of C3H mice.
Topics: Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Liver Neoplasms; Male; Mic | 1980 |
Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats.
Topics: Adenoma; Animals; Body Weight; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Diet; Diethyln | 1980 |
Diazepam and tumour promotion.
Topics: Animals; Cocarcinogenesis; Diazepam; Diethylnitrosamine; Female; Humans; Neoplasms; Neoplasms, Exper | 1981 |
Early appearance of histochemically altered hepatocyte foci and liver tumors in female rats treated with carcinogens one day after birth.
Topics: Animals; Animals, Newborn; Benzopyrenes; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltran | 1981 |
Glucose-6-phosphate dehydrogenase and gama-glutamyltranspeptidase activities in the liver during chemically induced hepatocarcinogenesis in rats and mice.
Topics: Animals; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver; | 1981 |
Enhancement of hepatocarcinogenesis by sequential administration of chemicals: summation versus promotion effects.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Iron; Li | 1981 |
Comparative tumor initiating activities of N-nitrosomethylbenzylamine and N-nitrosodimethylamine in rat liver.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; gamma-Glutamyltransferase; Hepatectomy; Injec | 1982 |
Occurrence of progressive DNA damage coincident with the appearance of foci of altered hepatocytes.
Topics: Animals; Diethylnitrosamine; DNA; Female; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neopl | 1982 |
Comparison of hepatic carcinogen initiation-promotion systems.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; Epoxide Hydrolases; gamma-Glut | 1982 |
On participation of the autonomic nervous system in the mechanisms of chemical carcinogenesis.
Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; | 1982 |
Polybrominated biphenyls as promoters in experimental hepatocarcinogenesis in rats.
Topics: Acyltransferases; Animals; Biphenyl Compounds; Carcinogens; Diethylnitrosamine; Female; Liver; Liver | 1982 |
Presence of alpha-fetoprotein-positive cells in hepatocellular foci and microcarcinomas induced by single injections of diethylnitrosamine in infant mice.
Topics: alpha-Fetoproteins; Animals; Carcinoma; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experi | 1983 |
[Studies on the mechanism of carcinogenesis. V. Differential changes in activities of enzymes involved in ornithine metabolism in early phase of hepatocarcinogenesis induced by diethylnitrosamine].
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Ornithine; Ornit | 1982 |
Sex-dependent promoting effect of polychlorinated biphenyls on enzyme-altered islands induced by diethylnitrosamine in rat liver.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Female; Live | 1982 |
Changes in developmental-specific enzyme activities during experimental hepatocarcinogenesis in the rat in vivo [proceedings].
Topics: Animals; Aspartate Aminotransferases; Cell Differentiation; Diethylnitrosamine; Glucokinase; Glucose | 1980 |
Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fibronectins; Glycopr | 1982 |
[Effects of apomorphine and haloperidol on experimental hepatocarcinogenesis].
Topics: Adenoma; Adenoma, Bile Duct; Animals; Apomorphine; Cell Transformation, Neoplastic; Diethylnitrosami | 1983 |
Assessment of nitrosamine transplacental carcinogenesis in the Syrian golden hamster.
Topics: Animals; Arvicolinae; Chromosome Aberrations; Diethylnitrosamine; Female; Fetus; Gestational Age; Ne | 1983 |
Tumor promoters and cocarcinogens in tobacco carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acids; Animals; Benzopyrenes; Cocarcinogenesis; Cricetinae; Diethy | 1983 |
Basic lead acetate: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Kidney Neoplasms; Lead; Male; Neoplasms, E | 1983 |
Alteration of natural killer cell-mediated cytotoxicity in rats treated with selenium, diethylnitrosamine and ethylnitrosourea.
Topics: Animals; Cyclophosphamide; Cytotoxicity, Immunologic; Diethylnitrosamine; Ethylnitrosourea; Female; | 1984 |
Influence of ethanol on some host reactions in the early stages of N-nitrosamine carcinogenesis.
Topics: Alkaline Phosphatase; Animals; Antibodies, Bacterial; Cell Movement; Diethylnitrosamine; Drug Intera | 1983 |
Tumorigenic effect of sodium arsenite in rat kidney.
Topics: Animals; Arsenic; Arsenites; Body Weight; Carcinogens; Diethylnitrosamine; Hepatectomy; Kidney Neopl | 1983 |
Carcinogenicity of diethylnitrosamine in newborn, infant, and adult mice.
Topics: Age Factors; Animals; Diethylnitrosamine; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, | 1984 |
The problem of thresholds in chemical carcinogenesis some views on theoretical and practical aspects.
Topics: Animals; Benzopyrenes; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Tolerance; Methyln | 1980 |
Effects of sequential exposure to aflatoxin B1 and diethylnitrosamine on vascular and stomach tissue and additional target organs in rats.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Diethylnitrosamine; H | 1980 |
Investigation on the combined action of N-nitrosodiethylamine with other carcinogens.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzopyrenes; Carcinogens; Diethylnitrosamine; Drug Synergism; Fe | 1980 |
Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally.
Topics: Animals; Carcinogens; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Male; Neoplasms, Experi | 1981 |
Chemicals, evolution, and cancer development: Rous-Whipple Award Lecture.
Topics: Adult; Aflatoxin B1; Aflatoxins; Animals; Biological Evolution; Carcinogens; Carcinogens, Environmen | 1982 |
Changes in activities of uridine diphosphate-glucuronyltransferases during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxyanisole; Diethylnitrosamine; Enzyme Induction; Gluc | 1982 |
[Localization of cytochrome P-450PB in the rat liver and primary liver tumors of different histological structure after administration of inductor aroclor 1254].
Topics: Adenocarcinoma; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Di | 1982 |
Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Resistance; Liver; Liver Neopl | 1983 |
Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Fluorescein; Fluoresceins; Liver; Liver Circulat | 1983 |
Sequential observations on the appearance of neoplastic lesions in the liver and kidney after treatment with N-ethyl-N-hydroxyethylnitrosamine followed by partial hepatectomy and unilateral nephrectomy.
Topics: Animals; Carcinogens; Diethylnitrosamine; Hepatectomy; Kidney Neoplasms; Liver Neoplasms; Male; Neop | 1983 |
[Studies on canceration of esophageal epithelium--(SEM) and (TEM) observations].
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylnitrosamine; Epit | 1983 |
Species specificity in nitrosamine carcinogenesis.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Liver Neoplasms; Lung Neopla | 1983 |
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplas | 1983 |
Binding of radioactivity after transplacental administration of tritiated N-nitrosodiethylamine to Syrian golden hamsters.
Topics: Animals; Cricetinae; Diethylnitrosamine; Female; Fetus; Gestational Age; Liver; Maternal-Fetal Excha | 1980 |
Lymphotoxin prevention of diethylnitrosamine carcinogenesis in vivo.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; Diethylnitrosamine; Female; Lymphotoxin-alpha; | 1982 |
A method for rapid scoring of respiratory tumors in hamsters.
Topics: Animals; Cricetinae; Diethylnitrosamine; Dose-Response Relationship, Drug; Histological Techniques; | 1980 |
[Use of radionuclides to study structural differences in mitochondrial and lysosomal membranes of normal and neoplastic cells].
Topics: Animals; Carcinoma, Ehrlich Tumor; Diethylnitrosamine; Gallium Radioisotopes; Indium; Intracellular | 1980 |
Relevance of basophilic foci to promoting effect of sex hormones on hepatocarcinogenesis.
Topics: Animals; Castration; Cocarcinogenesis; Diethylnitrosamine; Female; Gonadal Steroid Hormones; Kinetic | 1982 |
[Action of N-dinitrosopiperazine and N-nitrosodiethylamine on aquarium guppies].
Topics: Animals; Diethylnitrosamine; Female; Fish Diseases; Fishes; Male; Neoplasms, Experimental; Nitrosami | 1982 |
[Protein composition of the endoplasmic reticulum of normal rat liver cells and after exposure to the carcinogen N-nitrosodiethylamine].
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Endoplasmic Reticulum; Liver Neoplasms | 1982 |
[Lipid component of endoplasmic reticulum membranes in rat liver during carcinogenesis induced by nitrosodiethylamine].
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Endoplasmic Reticulum; Lipids; Liver N | 1982 |
Formaldehyde and tumors in hamster respiratory tract.
Topics: Adenoma; Aging; Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Formaldehyde; Male; Mesocricet | 1982 |
Carcinogenicity of N-nitrosodiethanolamine in rats at five different dose levels.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; | 1982 |
N-nitrosodiethanolamine: analysis, formation in tobacco products and carcinogenicity in Syrian golden hamsters.
Topics: Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Mesocricetus; Neoplasms, Experimental; Nicotia | 1982 |
Dose-response study on the carcinogenicity of N-nitrosodiethanolamine in male Sprague-Dawley rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Male; Neoplasms, Experim | 1982 |
Induction of preneoplastic and neoplastic lesions in rats treated N-nitroso compounds.
Topics: Animals; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relati | 1982 |
[Carcinogenic effect of N-dinitrosopiperazine and N-nitrosodietylamine in aquarium fishes].
Topics: Animals; Diethylnitrosamine; Fishes; Neoplasms, Experimental; Nitrosamines | 1982 |
Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine.
Topics: Acetaldehyde; Aerosols; Animals; Benzopyrenes; Body Weight; Carcinoma; Cricetinae; Diethylnitrosamin | 1982 |
Temporal advancement of diethylnitrosamine carcinogenesis in aging mice.
Topics: Aging; Animals; Diethylnitrosamine; Female; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms, Experi | 1981 |
Ultrastructure of spontaneous neoplasms induced by diethylnitrosamine and dieldrin in the C3H mouse.
Topics: Aging; Animals; Body Weight; Dieldrin; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, Inbred | 1980 |
Infant mouse as a sensitive bioassay system for carcinogenicity of N-nitroso compounds.
Topics: Adenoma; Aging; Animals; Animals, Newborn; Biological Assay; Diethylnitrosamine; Dose-Response Relat | 1980 |
Hepatic lesions in Lebistes reticulatus induced by N-nitrosodiethylamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Fishes; Liver; Liver Neoplasm | 1980 |
Some aspects of prenatal risk of N-nitrosodiethylamine carcinogenesis.
Topics: Animals; Cell Differentiation; Cricetinae; Diethylnitrosamine; Female; Fetus; Maternal-Fetal Exchang | 1980 |
Autoradiographic study of the distribution of bound radioactivity in the respiratory tract of Syrian hamsters given N-[3H]nitrosodiethylamine.
Topics: Animals; Autoradiography; Bronchi; Cricetinae; Diethylnitrosamine; Epithelium; Mesocricetus; Mucous | 1981 |
[Cell proliferation analysis of hyperplastic lesions during the liver carcinogenesis in rats by dietylnitrosamine as studied by 3H-thymidine autoradiography (author's transl)].
Topics: Animals; Autoradiography; Cell Division; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Ma | 1981 |
[Protective effect of cholestyramine in the hepatocarcinogenesis of the rat (author's transl)].
Topics: Animals; Bile Acids and Salts; Cholestyramine Resin; Diethylnitrosamine; Liver Cirrhosis, Experiment | 1981 |
The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Drug Evaluation, Preclinical; Enzyme Induction; | 1980 |
Dose-dependent enhancing effect of phenobarbital on hepatocarcinogenesis initiated by diethylnitrosamine in the rat.
Topics: Animals; Diet; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Synergism; Liver Neoplasms | 1981 |
Promotive effects of ethinyl estradiol in hepatocarcinogenesis initiated by diethylnitrosamine in male rats.
Topics: Animals; Diethylnitrosamine; Drug Synergism; Ethinyl Estradiol; Hyperplasia; Liver Neoplasms; Male; | 1981 |
The carcinogenicity of N-nitrosodiethanolamine, an environmental pollutant, in Syrian hamsters.
Topics: Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Environmental Pollution; Female; Laryngeal Neo | 1981 |
Inhibitory effect of 4,4'-diaminodiphenylmethane on liver, kidney and bladder carcinogenesis in rats ingesting N-ethyl-N-hydroxyethylnitrosamine or N-butyl-N-(4-hydroxybutyl) nitros-amine.
Topics: Aniline Compounds; Animals; Benzhydryl Compounds; Butylhydroxybutylnitrosamine; Carcinogens; Diethyl | 1981 |
Dose response studies of carcinogenesis in rats by nitrosodiethylamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Neoplasms, Experimental; Nitr | 1981 |
Ureido-ethyl-imidazolines active against autochtonous diethylnitrosamine-induced epidermoid, papillary and adenocarcinomatous tumors of the respiratory tract of Syrian hamsters and against human bronchogenic carcinomas in nu/nu mice.
Topics: Animals; Antineoplastic Agents; Carcinoma, Bronchogenic; Cricetinae; Diethylnitrosamine; Drug Evalua | 1981 |
Effect of bolandiol dipropionate (anabiol), an anabolic hormone, on diethylnitrosamine-induced hepatocarcinogenesis in rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Estrenes; Liver Neoplasms; Male; Neoplasms | 1981 |
Some conclusions derived from a liver model for carcinogenesis.
Topics: Animals; Biotransformation; Carcinogens; Diethylnitrosamine; Drug Resistance; Liver; Liver Neoplasms | 1981 |
Inhibition of the hepatocarcinogenic activity of diethylnitrosamine (DENA) by ethanol in rats.
Topics: Animals; Diethylnitrosamine; Esophageal Neoplasms; Ethanol; Liver Neoplasms, Experimental; Male; Neo | 1981 |
A light and electron microscopic study of liver and lung tumors induced by a single low dose of diethylnitrosamine (DEN) in C57BLXC3H F1 mice.
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Mice; Mice, Inbred C3H; M | 1981 |
Tumours induced in Fischer 344 rats by the feeding of disulfiram together with sodium nitrite.
Topics: Animals; Carcinogens; Diet; Diethylnitrosamine; Disulfiram; Drug Interactions; Esophageal Neoplasms; | 1980 |
Tumorigenicity of N-nitroso-diaethyl, -dimethyl and -diphenyl-amines in skin painting experiments. A study utilizing the tetrazolium test and skin applications on hairless mice.
Topics: Adenoma; Animals; Diethylnitrosamine; Dimethylnitrosamine; Female; Lung Neoplasms; Male; Mice; Neopl | 1980 |
SEM study of adult rat hepatocytes from preneoplastic and hyperplastic foci induced in the liver by diethylnitrosamine.
Topics: Animals; Cell Membrane; Diethylnitrosamine; Disease Models, Animal; Female; Hyperplasia; Liver; Live | 1980 |
Cytosolic levels and distribution of cadmium, copper and zinc in pretumorous livers from diethylnitrosamine-exposed mice and in non-cancerous kidneys cancer patients.
Topics: Animals; Cadmium; Copper; Cytosol; Diethylnitrosamine; Female; Humans; Kidney; Liver Neoplasms; Male | 1980 |
Carcinogenic dose-related response to nitrosamines.
Topics: Administration, Oral; Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Re | 1980 |
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dim | 1995 |
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus.
Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease M | 1994 |
Life-span and cancer: the induction time of tumors in diverse animal species treated with nitrosodiethylamine.
Topics: Aging; Animals; Diethylnitrosamine; Life Expectancy; Liver Neoplasms; Neoplasms, Experimental; Speci | 1993 |
A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis.
Topics: Animals; Body Weight; Diethylnitrosamine; Genetic Linkage; Liver Neoplasms; Liver Neoplasms, Experim | 1993 |
Effect of X rays alone or combined with diethylnitrosamine on tumor induction in infant mouse liver.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Neo | 1993 |
No enhancing effects of calcium/magnesium salts of L-glutamate and L-ascorbate on tumor development in a rat medium-term multiorgan carcinogenesis bioassay.
Topics: Animals; Ascorbic Acid; Body Weight; Carcinogens; Diethylnitrosamine; Glutamates; Male; Methylnitros | 1993 |
Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Carc | 1996 |
Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Cyclophosph | 1996 |
Induction of lung carcinogenesis in AKR-mice by N-nitrosodiethylamine/phenobarbitone, associated with high expression of c-myc and c-jun oncoproteins.
Topics: Animals; Carcinogens; Diethylnitrosamine; Lung Neoplasms; Male; Mice; Mice, Inbred AKR; Neoplasm Pro | 1997 |
Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Dieth | 1997 |
Effects of n-tritriacontane-16,18-dione, curcumin, chlorphyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model.
Topics: Aminobiphenyl Compounds; Animals; Antimutagenic Agents; Antineoplastic Agents; Antioxidants; Carcino | 1997 |
Studies of initiation and promotion of carcinogenesis by N-nitroso compounds.
Topics: Animals; Carcinogens; Carcinoma, Transitional Cell; Diethylnitrosamine; Ethylnitrosourea; Male; Meth | 1998 |
Chemopreventive effect of 24R,25-dihydroxyvitamin D(3) in N, N'-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 24,25-Dihydroxyvitamin D 3; Animals; Anticarcinogenic Agents; Butylhydroxybut | 2000 |
Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Alkylating Agents; Animals; Body Weight; Butylhydroxyb | 2000 |
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis.
Topics: Administration, Oral; Animals; Body Weight; Calcitriol; Carcinogens; Diethylnitrosamine; Drug Intera | 2000 |
Inhibition of chemical carcinogenesis by berberine in rats and mice.
Topics: Alkylating Agents; Animals; Berberine; Cell Transformation, Neoplastic; Diethylnitrosamine; Dose-Res | 2001 |
Anticarcinogenic effect of black tea on pulmonary tumors in Swiss albino mice.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine | 2002 |
Cancare-a herbal formulation inhibits chemically induced tumours in experimental animals.
Topics: Animals; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Methylcholanthrene; Mice; Mice, | 2001 |
[Adrenergic component in the hepatotropic, carcinogenic effect of diethylnitrosamine].
Topics: Adrenergic alpha-Antagonists; Animals; Antineoplastic Agents; Carcinogens; Diethylnitrosamine; Dioxa | 1977 |
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Fluorenes; gamm | 1977 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Diethylnitrosam | 1978 |
Gamma-glutamyl transpeptidase: a positive marker for cultured rat liver cells derived from putative premalignant and malignant lesions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; Enzyme Induction; | 1978 |
[Modification of chemical carcinogenesis with adrenergic compounds].
Topics: Adrenergic alpha-Antagonists; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Drug Ant | 1978 |
Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet.
Topics: Amino Acids; Animals; Body Weight; Carcinoma, Hepatocellular; Choline; Diet; Dietary Fats; Diethylni | 1977 |
In vitro alpha-fetoprotein synthesis by monkey hepatocellular carcinoma.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Haplorhini; In V | 1978 |
Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine | 1975 |
Transaminase level (GOT, GPT) in rats under treatment with diethylnitrosamine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Clinical Enzyme Tests; Diethylnitrosamin | 1975 |
Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Disulfiram; Esophageal Neoplasms; Liver Neoplasms; | 1976 |
Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; DNA Nucleotidyltransferases; Do | 1976 |
[Toxicological effects of diethylinitrosamine (DENA) in guppies (Lebistes reticulatus) (author's transl)].
Topics: Animals; Diethylnitrosamine; Female; Fishes; Kidney; Lethal Dose 50; Liver; Male; Neoplasms, Experim | 1976 |
The carcinogenic properties of some of the principal drugs used in clinical cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinogens; Chlorambucil; Cyclophosphamide; Dacarbazine; Dactinomyc | 1975 |
Hepatocarcinogenetic effect of DENA in pigs.
Topics: Animals; Carcinoma; Diethylnitrosamine; Liver Neoplasms; Neoplasm Metastasis; Neoplasms, Experimenta | 1977 |
The role of nicotinamide and of certain other modifying factors in diethylnitrosamine carcinogenesis: fusaria mycotoxins and "spontaneous" tumors in animals and man.
Topics: Animals; Diethylnitrosamine; Female; Fusarium; Gastrointestinal Neoplasms; Genital Neoplasms, Female | 1977 |
Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression.
Topics: Animals; Antilymphocyte Serum; Carcinoma, Hepatocellular; Diethylnitrosamine; Hydroxyurea; Immunosup | 1975 |
Protective tumor immunity induced by potassium chloride extracts of guinea pig hepatomas.
Topics: Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Diethylnitrosamine; Guinea Pigs; Immunizatio | 1975 |
[The tumor-tetanus assay--experimental studies on the biological differentiation between carcinogenesis and organ regeneration of the rat (author's transl)].
Topics: Agglutination Tests; Animals; Antibodies, Neoplasm; Antibody Formation; Carcinoma 256, Walker; Carci | 1975 |
Histologic and electron microscopy observations on diethylnitrosamine-induced hepatomas in small aquarium fish (Oryzias latipes).
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Endoplasmic Reticulum; Fishes; Golgi Apparat | 1975 |
Kinetics of induction and growth of precancerous liver-cell foci, and liver tumour formation by diethylnitrosamine in the rat.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Count; Diethylnitrosamine; Dose- | 1975 |
Proceedings: Glucocorticoid receptors and response in diethylnitrosamine-induced hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Dexamethasone; Diethylnitrosamine; Liver Neoplasms; Male; Neopla | 1975 |
Pituitary growth hormone and somatotrophs in rats bearing chemically induced hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Growth Hormone; Liver | 1976 |
Composition, associated tissue methyltransferase activity, and catabolic end products of transfer RNA from carcinogen-induced hepatoma and normal monkey livers.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Guanine; Guanosine; Haplorhini; Hypo | 1977 |
Nucleic acids from subcellular fractions of N-nitrosodiethylamine-induced hepatoma in mice.
Topics: Acridines; Animals; Carcinoma, Hepatocellular; Cell Nucleus; Dactinomycin; Diethylnitrosamine; DNA, | 1976 |
Sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose-6-Phospha | 1976 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Synergism; Liver Neoplasms; Male; Neopl | 1976 |
Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver Neoplasms; Lung; Male; Mi | 1977 |
Altered cobalamin distribution in rat hepatomas and in the livers of rats treated with diethylnitrosamine.
Topics: Animals; Carcinoma, Hepatocellular; Cobamides; Diethylnitrosamine; Female; Liver; Liver Neoplasms; N | 1977 |
The induction of tumors in Rana temporaria with nitrosamines.
Topics: Adenoma; Animals; Anura; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethylnitrosamine; Hematop | 1977 |
Discussion: some comments on the potential carcinogenicity of the clinically useful antitumor agents.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Haplorhi | 1977 |
In vivo initiated rat liver carcinogenesis studied in vitro; formation of alcoholic hyaline-type bodies.
Topics: Animals; Cell Nucleus; Cell Transformation, Neoplastic; Cells, Cultured; Cytoplasm; Diethylnitrosami | 1977 |
Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Haplorhini; Hepati | 1977 |
Tumor frequency and characteristics after a single dose of dimethylnitrosamine or diethylnitrosamine in partially hepatectomized rats.
Topics: Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethyl | 1977 |
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma].
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hexokinase; Isoenzymes; Liver Neoplasms; Neo | 1978 |
Nucleic acids from subcellular fractions of N-nitrosodiethylamine-induced hepatoma in mice. II. Changes in gene expression during tumor progression.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA, Mitochondrial; DNA, Neoplasm; Liver Neo | 1978 |
[Role of hyperplasia in hepatic carcinogenesis].
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Mice; N | 1978 |
Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice.
Topics: Animals; Benzidines; Benzopyrenes; Carcinoma, Hepatocellular; Diethylnitrosamine; Ethylnitrosourea; | 1978 |
Different deviation patterns of carbohydrate-metabolizing enzymes in primary rat hepatomas induced by different chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Cel | 1978 |
Suppression of chemical (DEN) carcinogenesis in SWR/J mice by goat antibodies against endogenous murine leukemia viruses.
Topics: Animals; Antibodies, Viral; Diethylnitrosamine; Female; Goats; Immunization, Passive; Immunoglobulin | 1978 |
Carcinogenesis of N-nitrosodiethylamine (DENA) in chickens and domestic cats.
Topics: Adenocarcinoma; Administration, Oral; Animals; Animals, Domestic; Carcinogens; Carcinoma, Hepatocell | 1978 |
Vinylethylnitrosamine: a potent respiratory carcinogen in Syrian hamsters.
Topics: Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Female; Gastrointestinal Neoplasms; Liver; Mal | 1977 |
Selective sex-related modification of diethylnitrosamine-induced carcinogenesis in BALB/c mice by concomitant administration of butylated hydroxytoluene.
Topics: Animals; Butylated Hydroxytoluene; Carcinoma, Squamous Cell; Cresols; Diethylnitrosamine; Enzyme Ind | 1978 |
Carcinogenicity of methylated derivatives of N-nitrosodiethylamine and related compounds in Sprague-Dawley rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; Esophageal Neoplasms; Female; Liver Neoplasms; Male; Methy | 1979 |
Changes in the labeling index and DNA content of liver cells during diethylnitrosamine-induced liver tumorigenesis in Oryzias latipes.
Topics: Animals; Autoradiography; Diethylnitrosamine; DNA; DNA, Neoplasm; Fishes; Fluorometry; Humans; Liver | 1979 |
The susceptibility of guinea pig cells to the colony-inhibitory activity of lymphotoxin during carcinogenesis.
Topics: Animals; Ascitic Fluid; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells | 1977 |
Ultrastructural and metabolic determinants of resistance to azo-dye susceptibility to nitrosamine carcinogenesis of the guinea-pig.
Topics: Animals; Diethylnitrosamine; Drug Resistance; Endoplasmic Reticulum; Liver Neoplasms; Male; Mice; Mi | 1977 |
5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Cytosine; Diethylnitrosamine; Hepatectomy; Liver; Live | 1979 |
Comparative studies of neoplastic response to a single dose of nitroso compounds. 6. The effect of diethylnitrosamine in Syrian golden hamsters.
Topics: Animals; Cricetinae; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Laryngeal Neoplas | 1979 |
Tissue differentiation as a prerequisite for transplacental carcinogenesis in the hamster respiratory system, with specific respect to the trachea.
Topics: Animals; Biotransformation; Cricetinae; Diethylnitrosamine; Endoplasmic Reticulum; Female; Gestation | 1979 |
[Comparative investigations on the organotropic carcinogenic effect of different N-nitroso compounds with rat after single and chronic treatment (author's transl)].
Topics: Animals; Benzyl Compounds; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Female; Ki | 1979 |
[Primary mechanism of a reduction in the intensity of extremely weak mitochondrial luminescence in the process of chemical hepatic carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Catalase; Diethylnitrosamine; Enzyme Activation; Liver Neoplasms; Lu | 1979 |
Effects of exposure to acetaldehyde in syrian hamsters simultaneously treated with benzo(a)pyrene or diethylnitrosamine.
Topics: Acetaldehyde; Animals; Benzopyrenes; Body Weight; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; | 1979 |
Inhalation studies with Syrian golden hamsters.
Topics: Aerosols; Animals; Asbestos; Atmosphere Exposure Chambers; Cobalt; Cricetinae; Diethylnitrosamine; L | 1979 |
A positive correlation between declining immune competence and early mortality associated with diethylnitrosamine carcinogenesis in aging mice.
Topics: Aging; Animals; Antibody Formation; Antibody-Producing Cells; Diethylnitrosamine; Dose-Response Rela | 1979 |
Effects of N-nitrosodiethanolamine and 1,1-diethanolhydrazine in Syrian golden hamsters.
Topics: Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Female; Hydrazines; Male; Neoplasms, Experimen | 1978 |
Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Liver Regenera | 1978 |
[Hepatic RNA resistance to enzymatic degradation in the process of hepatocarcinogenesis in rats].
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experime | 1978 |
Tumor induction by N-nitroso compounds in bivalve mollusks Unio pictorum.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Drug Evaluation, | 1978 |
Relative carcinogenic effectiveness of derivatives of nitrosodiethylamine in rats.
Topics: Administration, Oral; Animals; Diethylnitrosamine; Esophageal Neoplasms; Liver Neoplasms; Neoplasms, | 1978 |
Liver ornithine decarboxylase during phenobarbital promotion of nitrosamine carcinogenesis.
Topics: Animals; Carboxy-Lyases; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; | 1978 |
Temperature effects during and after the diethylnitrosamine treatment on liver tumorigenesis in the fish, Oryzias latipes.
Topics: Animals; Body Weight; Diethylnitrosamine; Fishes; Japan; Liver Neoplasms; Neoplasms, Experimental; N | 1978 |
[Membrane phospholipids of the rat liver endoplasmic reticulum normally and in the early stage of carcinogenesis].
Topics: Animals; Diethylnitrosamine; Endoplasmic Reticulum; Liver; Male; Membrane Lipids; Neoplasms, Experim | 1978 |
Ultrastructure of N-diethylnitrosamine induced tumours in the nasal olfactory region of the Syrian golden hamster.
Topics: Animals; Cricetinae; Diethylnitrosamine; Mesocricetus; Microscopy, Electron; Neoplasms, Experimental | 1978 |
Carcinoma of the nasal and paranasal regions in rats fed Cantonese salted marine fish.
Topics: Adenocarcinoma; Animals; Carcinoma; China; Cricetinae; Diet; Diethylnitrosamine; Female; Fishes; Foo | 1978 |
The effect of antilymphocytic and normal horse serum on growth of precancerous foci and development of tumours induced by diethylnitrosamine in rat liver.
Topics: Animals; Antilymphocyte Serum; Diethylnitrosamine; Female; Immunosuppression Therapy; Liver Neoplasm | 1976 |
The behaviour of deoxyribonucleases of rat liver in the course of diethylnitrosamine-induced carcinogenesis.
Topics: Animals; Deoxyribonucleases; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Neoplasms, Experime | 1975 |
[Glycogen and enzymes involved in its biosynthesis in rat liver during liver carcinogenesis caused by diethylnitrosamine].
Topics: Animals; Diethylnitrosamine; Glycogen Synthase; Liver Glycogen; Liver Neoplasms; Neoplasms, Experime | 1976 |
Screening of potential chemical carcinogens by means of mammalian cells in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cells, Cultured; Cricetinae; | 1976 |
Comparative study of the carcinogenic activities of nas and some chemical carcinogens when introduced into the buccal pouch of the Syrian hamster.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cheek; Cricetinae; Diethylnitrosamine; Dimet | 1976 |
Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine.
Topics: Animals; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diethylnitrosamine; Esophageal | 1977 |
The phosphorylation of histones in rat liver undergoing malignant transformation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Histones; | 1977 |
Carcinogenicity of N-nitrosodiethylamine in hibernating and nonhibernating European hamsters.
Topics: Adenocarcinoma; Animals; Basement Membrane; Carcinoma, Squamous Cell; Cricetinae; Diethylnitrosamine | 1977 |
Morphology of diethylnitrosamine-induced lung tumours in Dzungarian dwarf hamsters.
Topics: Adenocarcinoma; Adenoma; Animals; Cricetinae; Diethylnitrosamine; Lung Neoplasms; Neoplasms, Experim | 1977 |
Multi-hit kinetics of tumor formation, with special reference to experimental liver and human lung carcinogenesis and some gneral conclusions.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dose-Response Relationshi | 1977 |
Ultrastructural alterations of APUD cells during nitrosamine-induced lung carcinogenesis.
Topics: Animals; Cell Division; Cricetinae; Diethylnitrosamine; Lung Neoplasms; Male; Microscopy, Electron; | 1977 |
[Development of tumors in Unio pictorum bivalve mollusks under the influence of N-nitroso compounds].
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Methylnitronitrosoguanidine; Mollusca; Neoplasms, | 1977 |
Newer insights into the pathogenesis of liver cancer.
Topics: Aflatoxins; Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylnit | 1977 |
Effects of exposure to acrolein vapor in hamsters simultaneously treated with benzo[a]pyrene or diethylnitrosamine.
Topics: Acrolein; Aerosols; Aldehydes; Animals; Benzopyrenes; Body Weight; Carcinogens; Cricetinae; Diethyln | 1977 |
Some examples of dose-response studies in chemical carcinogenesis.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Mice; Neoplasms, Experimental; Nitros | 1976 |
Combination effects in chemical carcinogenesis (experimental results).
Topics: Animals; Carcinogens; Cocarcinogenesis; Cyclamates; Diethylnitrosamine; Disease Models, Animal; Dose | 1976 |
Diethylnitrosamine-induced changes in mouse liver morphology and function.
Topics: Animals; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Hexobarbital; Liver; Liver Neoplasms; M | 1976 |
Adenocarcinoma of the glandular stomach following 3-methylcholanthrene, N-nitrosodiethylamine, or N-nitrosodimethylamine feeding in carcinogen-susceptible inbred Syrian.
Topics: Adenocarcinoma; Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Female; Male; Mesocric | 1976 |
Carcinogenic effects of a single dose of diethylnitrosamine in three unrelated strains of mice: genetic dependence of the induced tumor types and incidence.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Genotype; Leukemia, Experimental; Liver Neoplasms; | 1976 |
Proliferation of endocrine (APUD-type) cells during early N-diethylnitrosamine-induced lung carcinogenesis in hamsters.
Topics: Animals; Cell Division; Cricetinae; Diethylnitrosamine; Epithelial Cells; Epithelium; Lung Neoplasms | 1976 |
Induction of renal pelvic tumours in Sprague-Dawley rats by di-isopropanolnitrosamine.
Topics: Animals; Carcinoma, Transitional Cell; Diethylnitrosamine; Female; Kidney Neoplasms; Male; Neoplasms | 1976 |
Carcinomas of the esophagus in rats ingesting diethylnitrosamine.
Topics: Administration, Oral; Animals; Bronchopneumonia; Carcinoma; Carcinoma, Squamous Cell; Diethylnitrosa | 1975 |
Properties and malignant transformation of established rat liver parenchymal cells in culture.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Azo Compounds; Benzopyrenes; Blood Proteins; Cell Transforma | 1975 |
Transplacental effects of diethylnitrosamine in Syrian hamsters as related to different days of administration during pregnancy.
Topics: Animals; Cricetinae; Diethylnitrosamine; Female; Gestational Age; Male; Maternal-Fetal Exchange; Neo | 1975 |
Effect of diet on DEN clearance and carcinogenesis in rats.
Topics: Animals; Diet; Diethylnitrosamine; Esophageal Neoplasms; Liver Neoplasms; Male; Neoplasms, Experimen | 1975 |
Failure to induce tumours in guinea-pigs after concurrent administration of nitrite and diethylamine.
Topics: Animals; Carcinogens; Diethylamines; Diethylnitrosamine; Drug Interactions; Guinea Pigs; Male; Neopl | 1975 |
Influence of a chronic administration of diethylnitrosamine on the relation between specific tissular and division functions in the rat liver.
Topics: Animals; Cell Division; Cholesterol 7-alpha-Hydroxylase; Circadian Rhythm; Diethylnitrosamine; Hepat | 1975 |
Lens culinaris lectin receptors in the plasma membrane of rat liver cells: comparative electron microscopic studies on normal cells, on cells in vivo transformed by diethylnitrosamine and on Zajdela ascites hepatoma cells.
Topics: Animals; Antigen-Antibody Complex; Cell Membrane; Diethylnitrosamine; Lectins; Liver; Liver Neoplasm | 1975 |
Concanavalin A receptors on normal rat liver cells, on rat liver cells in vivo transformed by diethylnitrosamine and on Zajdela ascites hepatoma cells of the rat: morphokinetic analysis of cell surface dynamics.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Concanavalin A; Diethylnitrosamine; Liver Neopl | 1975 |
Comparative study of the ultrastructure of Tracheal and pulmonary tumours induced by multiple intratracheal instillations of diethylnitrosamine in Syrian golden hamsters.
Topics: Adenoma; Animals; Cell Membrane; Cell Nucleus; Cilia; Cricetinae; Diethylnitrosamine; Epithelial Cel | 1975 |
Intrasplenic tumor formation in the syrian hamster (Mesocricetus auratus) after tracheal implants and treatment with diethylnitrosamine.
Topics: Animals; Carcinoma, Squamous Cell; Diethylnitrosamine; Female; Neoplasms, Experimental; Nitrosamines | 1976 |
Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine.
Topics: Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Esop | 1976 |
Mouse and rat strain variations in sensitivity to N-nitroso-diethylamine, hereditary transmission of the trait and the effect of 3-tert-butyl-4-hydroxyanisole on sensitivity.
Topics: Animals; Anticarcinogenic Agents; Butylated Hydroxyanisole; Cytochrome P-450 Enzyme System; Diethyln | 1992 |
Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital.
Topics: Animals; Antipyrine; Debrisoquin; Diethylnitrosamine; Liver; Male; Microsomes, Liver; Neoplasms, Exp | 1992 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
Mechanisms of fat-related modulation of N-nitrosodiethylamine-induced tumors in rats: organ distribution, blood lipids, enzymes and pro-oxidant state.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biotransformation; Body Weight; Cell Mem | 1991 |
The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors.
Topics: Adenoma; Alpha-Globulins; Animals; Body Weight; Carcinogens; Cell Division; Cyclohexenes; Diethylnit | 1991 |
Increased c-Ki-ras expression in hamster lung exposed to N-nitrosodiethylamine and hyperoxia as detected by the polymerase chain reaction.
Topics: Animals; Base Sequence; Cricetinae; Diethylnitrosamine; Endocrine System Diseases; Eosine Yellowish- | 1991 |
Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
Topics: Animals; Capsaicin; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Lung Neopla | 1991 |
Genetic control of susceptibility to diethylnitrosamine and dimethylbenzanthracene carcinogenesis in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diethylnitrosamine; Female; Genetic Predisposition to Dis | 1991 |
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; | 1991 |
Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model.
Topics: Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Disease Models, Animal; Germanium; Indole | 1991 |
Comparative transplacental carcinogenesis by directly acting and metabolism-dependent alkylating agents in rodents and nonhuman primates.
Topics: Alkylating Agents; Animals; Brain Neoplasms; Carcinogens; Choriocarcinoma; Diethylnitrosamine; Eryth | 1989 |
Scaling of fatal cancer risks from laboratory animals to man.
Topics: Animals; Bone Neoplasms; Diethylnitrosamine; Dogs; Dose-Response Relationship, Drug; Dose-Response R | 1989 |
[The dependence of the carcinogenic effect on the concentration of N-nitrosodiethylamine].
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Male; Maximum Allowable Conce | 1989 |
Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J mice and F344 rats.
Topics: Adenocarcinoma; Animals; Carcinogens; Diethylnitrosamine; Female; Hemangiosarcoma; Liver Neoplasms; | 1989 |
Predictability of human carcinogenicity from animal studies.
Topics: Aflatoxin B1; Aflatoxins; Animals; Diethylnitrosamine; Humans; Mutagenicity Tests; Neoplasms, Experi | 1986 |
A comparison of the carcinogenicity of N-nitrosodiethylamine and N-nitrosodimethylamine after intratracheal instillation into Syrian golden hamsters.
Topics: Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Liver Neoplasms, Experimental; Lung Ne | 1988 |
Carcinogenesis and nucleic acid alkylation by some oxygenated nitrosamines in rats and hamsters.
Topics: Administration, Oral; Alkylation; Animals; Cricetinae; Diethylnitrosamine; DNA; Liver Neoplasms; Met | 1988 |
High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances.
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Damage; Dose-Response Relationship, Drug; Female; Form | 1987 |
Comparison of lesions induced in the Syrian golden hamster by diethylnitrosamine, dimethylhydrazine, and dibutylnitrosamine: influence of subsequent butylated hydroxyanisole treatment.
Topics: Animals; Butylated Hydroxyanisole; Cricetinae; Diethylnitrosamine; Dimethylhydrazines; Glutathione T | 1987 |
Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug C | 1987 |
Carcinogenicity of diethylnitrosamine in vitamin-A-deficient mice.
Topics: Administration, Oral; Animals; Diethylnitrosamine; Disease Susceptibility; Female; Male; Mice; Mice, | 1987 |
Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Lung Neoplasms; Mice; Mice, Inbred ICR; Neoplas | 1986 |
Lack of carcinogenicity of triethanolamine in F344 rats.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Ethanolamines; Female; Kidney; Liver; | 1986 |
Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Drug Interactio | 1987 |
Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine.
Topics: Amobarbital; Animals; Barbital; Barbiturates; Body Weight; Diethylnitrosamine; Liver Neoplasms, Expe | 1985 |
Association of nitrosamine-derived radioactivity with nuclear and mitochondrial DNA in mice.
Topics: Animals; Carbon Radioisotopes; Cell Nucleus; Diethylnitrosamine; Dimethylnitrosamine; DNA; DNA Repai | 1985 |
Influence of a prolonged treatment with disulfiram and D-penicillamine on nitrosodiethylamine-induced biological and biochemical effects. II. Investigations on trace elements in the liver.
Topics: Animals; Diethylnitrosamine; Disulfiram; Drug Interactions; Liver; Male; Neoplasms, Experimental; Ni | 1985 |
Influence of a prolonged treatment with disulfiram and D(-)penicillamine on nitrosodiethylamine-induced biological and biochemical effects in rats. I. Investigations on the drug metabolizing system.
Topics: Animals; Diethylnitrosamine; Disulfiram; Drug Interactions; Enzyme Inhibitors; Esophageal Neoplasms; | 1985 |
Pathology and tumor development through time in guppies dosed with diethylnitrosamine (DEN).
Topics: Animals; Diethylnitrosamine; Fishes; Liver; Liver Neoplasms; Neoplasms, Experimental; Time Factors; | 1985 |
[Experimental study of the effect of combinations of chemical water pollutants on carcinogenesis].
Topics: Animals; Benzene; Cadmium; Carbon Tetrachloride; Cocarcinogenesis; Diethylnitrosamine; Female; Mice; | 1985 |