diethylnitrosamine has been researched along with Experimental Hepatoma in 1373 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study demonstrated that purple rice bran extract (PRBE) could inhibit diethylnitrosamine (DEN)-induced hepatocarcinogenesis." | 8.12 | Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Luangsuphabool, T; Punvittayagul, C; Wongpoomchai, R, 2022) |
| "Diethylnitrosamine (DEN) and 1,2-dimethylhydrazine (DMH) are classical carcinogens used in experimental rodent carcinogenesis." | 7.91 | Augmentation of diethylnitrosamine-induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine. ( Chariyakornkul, A; Chewonarin, T; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2019) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 7.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "This study aimed to evaluate the antitumor activity of platinum nanoparticles compared with cis-platin both in vitro and in vivo in the treatment of hepatocellular carcinoma induced in rats." | 7.85 | Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats. ( El-Sonbaty, S; Kandil, E; Mahmoud, M; Mansour, S; Medhat, A, 2017) |
| "The purpose of the present study was to evaluate the effects of cordycepin (CA) on N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinomas (HCC) and explore its potential mechanisms." | 7.85 | Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB pathway in mice. ( Chen, B; Li, D; Lian, S; Lin, X; Wei, H; Yang, T; Zeng, Y, 2017) |
| " Using the Solt and Farber protocol in a rat model of hepatocarcinogenesis, the chemopreventive effect of EPM on diethylnitrosamine (DEN)-initiated, 2-acetylaminofluorene (2-AAF) and partial hepatectomy (PH)-promoted liver carcinogenesis in rats was evaluated." | 7.85 | Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats. ( Chang, HY; Chen, YC; Huang, GJ; Huang, SS; Lai, HC; Lu, CC; Yang, CH, 2017) |
| " The present experimental study was designed to outline the roles of these players and to investigate the tumor suppressive effects of curcumin with or without mesenchymal stem cells (MSCs) in hepatocellular carcinoma (HCC)." | 7.81 | Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy. ( Abdelmaqsoud, OM; Khaleel, EF; Tork, OM, 2015) |
| "The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model." | 7.80 | Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats. ( Geng, CZ; Liu, YP; Peng, L; Wang, SJ; Wang, X; Yang, HC; Zhao, JA, 2014) |
| " The aim of this study was to investigate the possible therapeutic efficiency of myrtenal against diethylnitrosamine-induced experimental hepatocarcinogenesis by analyzing the key enzymes of carbohydrate metabolism, lysosomal and mitochondrial TCA cycle enzymes, and also the possible role of tumor suppressor protein p53, and scanning electron microscopic studies." | 7.79 | Myrtenal ameliorates diethylnitrosamine-induced hepatocarcinogenesis through the activation of tumor suppressor protein p53 and regulation of lysosomal and mitochondrial enzymes. ( Lingaiah, HB; Natarajan, N; Periyasamy, BM; Srinivasan, P; Thamaraiselvan, R, 2013) |
| "Placental growth factor (PlGF) inhibition produced promising results in reducing tumor burden in a diethylnitrosamine (DEN)-induced mouse model for hepatocellular carcinoma (HCC)." | 7.79 | Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor. ( Blomme, B; Colle, I; Geerts, A; Heindryckx, F; Stassen, JM; Van Vlierberghe, H, 2013) |
| " DENA (diethylnitrosamine), a hepatocarcinogen, is commonly used in an experimental mouse model to induce liver cancer that closely mimics a subclass of human hepatocellular carcinoma (HCC)." | 7.76 | Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer. ( Chen, CC; Contreras, R; Dewaele, S; Fan, YD; Libert, C; Liu, XE; Van Huysse, J; Vanhooren, V; Wang, L; Zhuang, H, 2010) |
| " In our continuous search to discover bioactive compounds from natural products, we isolated (5R, 10R)-4R, 8R-dihydroxy-2S, 3R:15, 16-diepoxycleroda-13(16), 17, 12S:18,1S-dilactone (ECD), a diterpenoid from Tinospora cordifolia and studied its chemopreventive potential in diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) rats." | 7.75 | Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. ( Agastian, P; Baskar, AA; Dhanasekaran, M; Duraipandiyan, V; Ignacimuthu, S, 2009) |
| "In rats with diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC), we studied in vivo gene transfer efficiency using intraportal injections of recombinant adenovirus carrying the lacZ reporter gene (AdCMVlacZ) and the therapeutic efficacy of adenovirus-mediated transfer of the thymidine kinase gene of the herpes simplex virus (HSV-tk) followed by ganciclovir (GCV) administration." | 7.69 | Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma. ( Bilbao, R; Bruña, O; Idoate, M; Prieto, J; Qian, C; Sangro, B; Vázquez, J, 1997) |
| "The ultrastructure of peritoneal macrophages of rats with chronic fascioliasis and the carcinogenic effect of diethylnitrosamine (DENA) were studied." | 7.68 | Electron microscopic study of the peritoneal macrophages of rats with chronic fascioliasis and the carcinogenic effect of diethylnitrosamine. ( Krustev, L; Mizinska-Boevska, Y; Polyakova-Krusteva, O; Tsocheva, N, 1990) |
| "In rats, hexachlorobenzene (HCB) causes uroporphyria and liver tumours predominantly in females." | 7.67 | Hexachlorobenzene as a promoter of diethylnitrosamine-initiated hepatocarcinogenesis in rats and comparison with induction of porphyria. ( Cabral, JR; Manson, MM; Smith, AG; Stewart, FP, 1989) |
| "Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat." | 7.66 | Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. ( Farber, E; Sarma, DS; Ying, TS, 1981) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 5.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| "ADI can inhibit a lot of CYP450 enzyme, so it may reduce the dosage of chemotherapeutic drugs to reach the required plasma concentration of chemotherapeutic drugs, which is of great significance for the combination of anti-tumor chemotherapeutic drugs and is worthy of further in-depth study and clinical attention." | 5.72 | Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats. ( He, Y; Huang, Y; Jin, Y; Li, Y; Liu, W; Lu, Y; Pan, J; Wang, Y; Zheng, L, 2022) |
| "Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality." | 5.62 | Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma. ( Balaraman, G; Krishnan, P; Mari, A; Salam, S; Sirajduddin, I; Subramaniam, N; Sundaram, J; Thiruvengadam, D, 2021) |
| "Liver cancer was induced in mice with hepatocyte-specific disruption of Myc and control mice by administration of diethylnitrosamine." | 5.62 | Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. ( Cai, J; Chen, L; Gao, Y; Gonzalez, FJ; Guo, X; Jiang, J; Krausz, KW; Liu, W; Luo, Y; Qu, A; Sun, L; Takahashi, S; Tang, W; Wang, Y; Xie, C; Yang, S; Yang, Y, 2021) |
| " Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation." | 5.56 | Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 5.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| "Treatment of DEN-induced hepatocellular carcinoma Wistar rats with the extract caused significant (p < 0." | 5.56 | Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats. ( Adebayo, AH; Adelani, IB; Adesina, GO; Edokwe, CB; Metibemu, DS; Oseha, OE; Yakubu, OF, 2020) |
| "Echinacoside (ECH) is a phenylethanoid glycoside extracted from a Chinese herbal medicine, Cistanches salsa." | 5.51 | Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells. ( Ni, J; Song, Y; Wang, G; Xia, W; Ye, Y; Zhuang, J, 2019) |
| "Hepatocellular carcinoma is the most frequent kind of primary liver cancer and occurs mostly in patients with chronic liver disease and cirrhosis." | 5.51 | Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway. ( Cui, G; Shang, X; Wang, N; Yang, G; Zhao, H; Zhao, L, 2019) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 5.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "At present, the treatment of hepatocellular carcinoma (HCC) is an international problem." | 5.42 | Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Chen, Q; Li, Y; Liu, W; Tang, H; Yang, X; Zhao, X, 2015) |
| "Interestingly, HFD, which induced hyperlipidemia and hepatic steatosis, attenuated DEN-related malnutrition and fibrosis progression in HFD + DEN group during 10-14 weeks." | 5.40 | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. ( Ding, WJ; Duan, XY; Fan, JG; Pan, Q; Qiao, L; Yan, SY, 2014) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 5.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| "Ursolic acid is a natural triterpenoid widely found in food, medicinal herbs, apple peel and other products it has been extensively studied for its anticancer and antioxidant properties." | 5.35 | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2009) |
| "Recently, human non-alcholic steatohepatitis (NASH) has been focused of attention regarding hepatocellular carcinoma." | 5.34 | High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice. ( Fukushima, S; Hagihara, A; Iwai, S; Makino, S; Min, W; Mori, S; Morimura, K; Murai, T; Seki, S, 2007) |
| "The question whether hepatocellular carcinoma (HCC) arises from dedifferentiation of mature hepatocytes or from proliferation of liver stem cells is still debated." | 5.31 | Demonstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats. ( Bralet, MP; Ferry, N; Pichard, V, 2002) |
| "25% salt in drinking water improved body weight reduction associated with sodium and water retention in hepatocellular carcinoma rats, which was suppressed by treatment with spironolactone, a mineralocorticoid receptor antagonist." | 4.12 | Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats. ( Kidoguchi, S; Kitada, K; Kittikulsuth, W; Kobara, H; Masaki, T; Nakajima, K; Nakano, D; Nishiyama, A; Ohsaki, H; Takahashi, K; Titze, J; Yokoo, T, 2022) |
| "Our previous study demonstrated that purple rice bran extract (PRBE) could inhibit diethylnitrosamine (DEN)-induced hepatocarcinogenesis." | 4.12 | Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Luangsuphabool, T; Punvittayagul, C; Wongpoomchai, R, 2022) |
| "Swiss Albino (BALB/c) mice of around 10-12 weeks old were exposed to a known hepatocarcinogen-diethylnitrosamine at a dose of 20 mg/kg body weight at weekly intervals for a period of 4, 8, 12, & 16 weeks." | 4.12 | Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma. ( Kma, L; Priya, S, 2022) |
| " In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis." | 4.02 | Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks. ( Campbell, MJ; Clinton, SK; Coss, CC; Getaneh, S; Helms, TH; Kulp, SK; LeMoine, DM; Lucas, F; Mullins, RD; Phelps, MA; Schmidt, N; Thomas-Ahner, JM; Xie, Z, 2021) |
| " In the second set of experiments, hypertrophy of the adipocytes was suppressed, and the concentration of adiponectin and leptin in the adipose tissue decreased by MCT." | 3.91 | Effects of Medium-chain Triglycerides Administration in Chemically-induced Carcinogenesis in Mice. ( Akazawa, Y; Fujii, H; Fukushima, H; Hagio, K; Ichikawa, D; Kono, H; Maruyama, S; Nakata, Y; Wakana, H, 2019) |
| "Diethylnitrosamine (DEN) and 1,2-dimethylhydrazine (DMH) are classical carcinogens used in experimental rodent carcinogenesis." | 3.91 | Augmentation of diethylnitrosamine-induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine. ( Chariyakornkul, A; Chewonarin, T; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2019) |
| " We observed that FUN14 domain-containing 1 (FUNDC1), a previously characterized mitophagy receptor, accumulates in most human hepatocellular carcinomas (HCCs), and we thus explored the role of FUNDC1-mediated mitophagy in HCC initiation and progression in a mouse model in which HCC is induced by the chemical carcinogen, diethylnitrosamine (DEN)." | 3.91 | FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice. ( Chen, Q; Du, L; Fan, Y; Huang, X; Jin, H; Li, W; Li, Y; Liu, L; Siraj, S; Wang, J; Wang, X; Yang, X, 2019) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 3.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "In hepatocarcinogenesis induced by diethylnitrosamine (DEN) in B6C3F1 mice, the BrafV637E mutation, corresponding to the human BRAFV600E mutation, plays a pivotal role." | 3.91 | Overproduction of thrombopoietin by BRAFV600E-mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis. ( Asari, M; Horioka, K; Ogawa, K; Okuda, K; Shimizu, K; Tanaka, H; Yamamoto, M; Yamazaki, K, 2019) |
| " We studied mice with bile-duct ligation, orthotopic cholangiocarcinomas, cholestasis-induced cholangiocarcinoma, diethylnitrosamine-induced liver tumors, and xenograft tumors." | 3.88 | Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. ( Annamalai, A; Fan, W; Li, TWH; Liu, T; Liu, Z; Lu, SC; Maldonado, SS; Mato, JM; Noureddin, M; Seki, E; Shen, H; Steggerda, J; Tu, J; Wang, J; Xiong, T; Yang, H; Yang, J, 2018) |
| "This study aimed to evaluate the antitumor activity of platinum nanoparticles compared with cis-platin both in vitro and in vivo in the treatment of hepatocellular carcinoma induced in rats." | 3.85 | Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats. ( El-Sonbaty, S; Kandil, E; Mahmoud, M; Mansour, S; Medhat, A, 2017) |
| "The purpose of the present study was to evaluate the effects of cordycepin (CA) on N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinomas (HCC) and explore its potential mechanisms." | 3.85 | Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB pathway in mice. ( Chen, B; Li, D; Lian, S; Lin, X; Wei, H; Yang, T; Zeng, Y, 2017) |
| " Using the Solt and Farber protocol in a rat model of hepatocarcinogenesis, the chemopreventive effect of EPM on diethylnitrosamine (DEN)-initiated, 2-acetylaminofluorene (2-AAF) and partial hepatectomy (PH)-promoted liver carcinogenesis in rats was evaluated." | 3.85 | Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats. ( Chang, HY; Chen, YC; Huang, GJ; Huang, SS; Lai, HC; Lu, CC; Yang, CH, 2017) |
| "The purpose of this study was to reduce the time to tumor onset in a diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) swine model via partial liver embolization (PLE) and to characterize the model for use in translational research." | 3.83 | Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs. ( Amin, HM; Avritscher, R; Cressman, E; Eskandari, G; Kaseb, AO; Konnath George, S; Mitchell, J; Morris, JS; Rashid, A; Tinkey, PT; Uthamanthil, R; Van Pelt, C; Xiao, L, 2016) |
| "These data indicate that dietary sugar intake contributes to liver tumor burden independent of excess adiposity or insulin resistance in mice treated with diethylnitrosamine." | 3.81 | Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine. ( Breen, DS; Byrne, FL; Caldwell, SH; Chow, JD; Healy, ME; Hoehn, KL; Lackner, C; Leitinger, N; Li, C, 2015) |
| " The present experimental study was designed to outline the roles of these players and to investigate the tumor suppressive effects of curcumin with or without mesenchymal stem cells (MSCs) in hepatocellular carcinoma (HCC)." | 3.81 | Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy. ( Abdelmaqsoud, OM; Khaleel, EF; Tork, OM, 2015) |
| "The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model." | 3.80 | Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats. ( Geng, CZ; Liu, YP; Peng, L; Wang, SJ; Wang, X; Yang, HC; Zhao, JA, 2014) |
| " The chemically-induced mouse model of diethylnitrosamine (DEN) provides useful insight into liver carcinogenesis, namely HCC." | 3.80 | The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions. ( Colaço, A; Da Costa, RM; Lopes, C; Oliveira, PA; Paula-Santos, N; Rocha, AF, 2014) |
| " The aim of this study was to investigate the possible therapeutic efficiency of myrtenal against diethylnitrosamine-induced experimental hepatocarcinogenesis by analyzing the key enzymes of carbohydrate metabolism, lysosomal and mitochondrial TCA cycle enzymes, and also the possible role of tumor suppressor protein p53, and scanning electron microscopic studies." | 3.79 | Myrtenal ameliorates diethylnitrosamine-induced hepatocarcinogenesis through the activation of tumor suppressor protein p53 and regulation of lysosomal and mitochondrial enzymes. ( Lingaiah, HB; Natarajan, N; Periyasamy, BM; Srinivasan, P; Thamaraiselvan, R, 2013) |
| "Placental growth factor (PlGF) inhibition produced promising results in reducing tumor burden in a diethylnitrosamine (DEN)-induced mouse model for hepatocellular carcinoma (HCC)." | 3.79 | Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor. ( Blomme, B; Colle, I; Geerts, A; Heindryckx, F; Stassen, JM; Van Vlierberghe, H, 2013) |
| " Rats received an intraperitoneal (ip) injection of 200 mg/kg body weight of N-diethylnitrosamine (DEN) and fed a diet containing 0, 0." | 3.78 | Mechanistic study on liver tumor promoting effects of flutamide in rats. ( Hayashi, H; Inokuma, H; Mitsumori, K; Shibutani, M; Shimamoto, K; Suzuki, K; Tawfeeq, MM, 2012) |
| "Human hepatocellular carcinoma cells in culture, as well as nude mice transplanted with hepatocellular carcinoma cells and rats given with N-diethylnitrosamine were treated with acyclic retinoid." | 3.77 | Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells. ( Fukaya, Y; Ishibashi, N; Kojima, S; Moriwaki, H; Okuno, M; Sano, T; Tatsukawa, H; Watanabe, M, 2011) |
| "Pitavastatin is effective in inhibiting the early phase of obesity-related liver tumorigenesis and, therefore, may be useful in the chemoprevention of liver cancer in obese individuals." | 3.77 | Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Sakai, H; Shimizu, M; Tanaka, T; Terakura, D; Tsurumi, H; Yasuda, Y, 2011) |
| "Sorafenib is an FDA-approved agent for treatment of human hepatocellular carcinoma (HCC), but tumor shrinkage is minor." | 3.77 | c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition. ( Carr, BI; Cavallini, A; D'Alessandro, R; Refolo, MG; Wang, M; Wang, Z, 2011) |
| ") against diethylnitrosamine (DEN) induced hepatocellular carcinoma in rats." | 3.77 | The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats. ( Abdel-Hamid, AH; Ammar, NM; Farrag, AR; Ghanem, KZ; Kholeif, TE; Metwally, NS, 2011) |
| " The serum levels of glucose and leptin decreased by dietary BCAA, whereas the value of the quantitative insulin sensitivity check index increased by this agent, indicating the improvement of insulin resistance and hyperleptinemia." | 3.76 | Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. ( Iwasa, J; Moriwaki, H; Sakai, H; Shimizu, M; Shirakami, Y; Shiraki, M; Takai, K; Tanaka, T; Terakura, Y; Tsurumi, H, 2010) |
| "From our findings we conclude that bacoside A is effective to prevent DEN-induced hepatocellular carcinoma by quenching lipid peroxidation and enhancing antioxidant status through free radical scavenging mechanism and having potential of protecting endogenous enzymatic and non-enzymatic antioxidant activity." | 3.76 | Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. ( Geetha, A; Janani, P; Parthasarathy, C; Ravisankar, B; Sivakumari, K, 2010) |
| " DENA (diethylnitrosamine), a hepatocarcinogen, is commonly used in an experimental mouse model to induce liver cancer that closely mimics a subclass of human hepatocellular carcinoma (HCC)." | 3.76 | Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer. ( Chen, CC; Contreras, R; Dewaele, S; Fan, YD; Libert, C; Liu, XE; Van Huysse, J; Vanhooren, V; Wang, L; Zhuang, H, 2010) |
| " In our continuous search to discover bioactive compounds from natural products, we isolated (5R, 10R)-4R, 8R-dihydroxy-2S, 3R:15, 16-diepoxycleroda-13(16), 17, 12S:18,1S-dilactone (ECD), a diterpenoid from Tinospora cordifolia and studied its chemopreventive potential in diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) rats." | 3.75 | Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. ( Agastian, P; Baskar, AA; Dhanasekaran, M; Duraipandiyan, V; Ignacimuthu, S, 2009) |
| "Gadolinium-enhanced multi-phase dynamic imaging has improved the accuracy of the diagnosis of hypervascular hepatocellular carcinoma (HCC), but using gadolinium-enhanced dynamic imaging alone is problematic in evaluating hypovascular HCC." | 3.75 | Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents. ( Bian, J; Guo, DM; Liu, SF; Qiu, TS; Wang, CZ, 2009) |
| "Experiments were designed to examine the effect of N-Nitrosodiethylamine (NDEA) as cancer-inducer compound and to confirm the preventive effect of the flavonoid quercetin on hepatocellular carcinoma in rats." | 3.75 | Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences. ( Elmaghraby, TK; Hafez, EE; Ibrahim, SS; Seufi, AM, 2009) |
| "We investigated whether changes in apoptosis and cell proliferation induced by starvation and refeeding in rat liver may contribute to the initiation mechanism of liver cancer by 20 mg/kg of diethylnitrosamine (DENA)." | 3.70 | Apoptosis and cell proliferation are involved in the initiation of liver carcinogenesis by a subnecrogenic dose of diethylnitrosamine in refed rats. ( Tessitore, L, 2000) |
| "In previous studies, we found that male D2B6F1 mice fed phenobarbital (PB) for 53 weeks following N-nitrosodiethylamine (NDEA) initiation developed a high (70-80%) incidence of malignant hepatoblastomas." | 3.69 | Further evidence for promoter-dependent development of hepatoblastoma in the mouse. ( Diwan, BA; Henneman, JR; Rice, JM, 1995) |
| " When administered 1 or 3 days after N-diethylnitrosamine initiation and partial hepatectomy, colchicine increased the mitotic index of regenerating hepatocytes at days 4-6 without evidence of liver cell necrosis." | 3.69 | Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicine-induced cell cycle disturbance in partially hepatectomized rats. ( Kobitsu, K; Konishi, Y; Mori, Y; Nakajima, Y; Nakano, H; Ohashi, K; Okajima, E; Takahashi, M; Tsujiuchi, T; Tsutsumi, M, 1996) |
| "In rats with diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC), we studied in vivo gene transfer efficiency using intraportal injections of recombinant adenovirus carrying the lacZ reporter gene (AdCMVlacZ) and the therapeutic efficacy of adenovirus-mediated transfer of the thymidine kinase gene of the herpes simplex virus (HSV-tk) followed by ganciclovir (GCV) administration." | 3.69 | Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma. ( Bilbao, R; Bruña, O; Idoate, M; Prieto, J; Qian, C; Sangro, B; Vázquez, J, 1997) |
| "The gene expression of HGF and HGFR in the canceration course of rats was determined by using experimental hepatomas model of Wistar rats established by diethylnitrosamine (DENA), with digoxigenin-labled probe." | 3.69 | [Gene expression of HGF and its receptor in experimental hepatomas]. ( Chen, H; Luo, Y; Wu, M, 1996) |
| "The present study examines the dose-response relationship for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) promotion of histologic and biochemical parameters by using a two-stage model for hepatocarcinogenesis in female Sprague-Dawley rats initiated with a single intraperitoneal dose of 175 mg of diethylnitrosamine (DEN)/kg body weight at 70 days of age." | 3.68 | Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints. ( Clark, G; Foley, JF; Goldsworthy, T; Lucier, G; Maronpot, RR; Portier, C; Takahashi, K; Tritscher, A, 1993) |
| "The ability of diethylnitrosamine (DENA) to initiate and phenobarbital to promote altered-hepatocyte foci and hepatocellular carcinomas in C3H and C3B6F1 (C3H x C57BL/6) mice was compared to the extent of cell proliferation." | 3.68 | Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation. ( Pereira, MA, 1993) |
| " Liver carcinogenesis was initiated by intraperitoneal injection of diethylnitrosamine (DEN) in male B6C3F1 mice at 100 or 200 mumol/kg body weight once a week for 10 weeks (total exposure 1000 or 2000 mumol/kg body weight)." | 3.68 | Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis. ( Iatropoulos, MJ; Tokumo, K; Williams, GM, 1991) |
| " Two types of areas composed of basophilic or glycogenotic hepatocytes were observed preceding the appearance of hepatocellular adenomas and carcinomas." | 3.68 | Rat hepatocarcinogenesis induced by N-nitrosodiethylamine and N-nitrosomorpholine continuously administered at low doses. From basophilic areas of hepatocytes to hepatocellular tumors. ( Cortinovis, C; Klimek, F; Nogueira, E, 1991) |
| " However, when females and males were exposed to four promotion regimens including orotic acid (OA), choline deficiency, deoxycholic acid (DOC), or selection for resistance (to 2-acetylaminofluorene; 2-AAF) after DEN initiation, very significant sex differences were observed with respect to oval cell proliferation and growth rates of hepatocytic foci." | 3.68 | Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine. ( Armstrong, D; Blanck, A; Cameron, RG, 1990) |
| "The ultrastructure of peritoneal macrophages of rats with chronic fascioliasis and the carcinogenic effect of diethylnitrosamine (DENA) were studied." | 3.68 | Electron microscopic study of the peritoneal macrophages of rats with chronic fascioliasis and the carcinogenic effect of diethylnitrosamine. ( Krustev, L; Mizinska-Boevska, Y; Polyakova-Krusteva, O; Tsocheva, N, 1990) |
| " Each of 50 rats per group received one injection 20 mg diethylnitrosamine [(DENA) CAS: 55-18-5; N-nitrosodiethylamine]/kg body weight at 4 weeks of age, and then each was maintained on a methyl group-adequate (MA) diet for 52 weeks (groups 2 and 5) or on an MD diet for 15 weeks followed by the MA diet for 37 weeks (group 4)." | 3.67 | Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection. ( Hoover, KL; Lynch, PH; Poirier, LA, 1984) |
| "Cell nuclear DNA ploidy patterns were examined using cytofluorometry in hepatocellular carcinomas (HCC) induced by diethylnitrosamine (DEN) in rat and human HCC." | 3.67 | [Biological activity of hepatocellular carcinoma by analysing nuclear DNA ploidy patterns and using anti BrdU monoclonal antibody]. ( Jung-Rou, T, 1989) |
| "In rats, hexachlorobenzene (HCB) causes uroporphyria and liver tumours predominantly in females." | 3.67 | Hexachlorobenzene as a promoter of diethylnitrosamine-initiated hepatocarcinogenesis in rats and comparison with induction of porphyria. ( Cabral, JR; Manson, MM; Smith, AG; Stewart, FP, 1989) |
| " Rats were initially given a single ip injection of diethylnitrosamine (200 mg/kg body weight) and fed basal diet containing 0." | 3.67 | Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. ( Inoue, K; Ito, N; Masui, T; Ogiso, T; Tsuda, H, 1986) |
| "Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat." | 3.66 | Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. ( Farber, E; Sarma, DS; Ying, TS, 1981) |
| "0 micrograms of diethylnitrosamine (DEN) per gram body weight in 15-day-old C57BL/6J X C3HeB/FeJ F1 (B6C3 F1) mice." | 3.66 | Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy. ( Goldfarb, S; He, YZ; Koen, H; Pugh, TD, 1983) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 1.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| "Alcohol is a well-known risk factor for hepatocellular carcinoma." | 1.72 | Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis. ( Ballabio, A; Chao, X; Ding, WX; Hlobik, M; Ni, HM; Wang, S, 2022) |
| "ADI can inhibit a lot of CYP450 enzyme, so it may reduce the dosage of chemotherapeutic drugs to reach the required plasma concentration of chemotherapeutic drugs, which is of great significance for the combination of anti-tumor chemotherapeutic drugs and is worthy of further in-depth study and clinical attention." | 1.72 | Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats. ( He, Y; Huang, Y; Jin, Y; Li, Y; Liu, W; Lu, Y; Pan, J; Wang, Y; Zheng, L, 2022) |
| "Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality." | 1.62 | Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma. ( Balaraman, G; Krishnan, P; Mari, A; Salam, S; Sirajduddin, I; Subramaniam, N; Sundaram, J; Thiruvengadam, D, 2021) |
| "The role of TTP in nonalcoholic steatohepatitis and HCC development was further examined through in vivo/vitro approaches using liver-specific TTP knockout mice and a panel of hepatic cancer cells." | 1.62 | Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. ( Bejuy, O; Berthou, F; Blackshear, PJ; Colin, DJ; Correia de Sousa, M; De Vito, C; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Rubbia-Brandt, L; Sobolewski, C, 2021) |
| "Phenobarbital treated mice showed damped corticosterone levels and a less stable 24 hours activity rhythm as well as an increase in activity during the light phase, reminiscent of sleep disruption." | 1.62 | Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model. ( Ali, AAH; Hassan, SA; Jänicke, RU; Korf, HW; Pfeffer, M; Sohn, D; von Gall, C; Yassine, M, 2021) |
| " Here, we describe steps to establish liver cancer in a rat model, via chronic administration of diethylnitrosamine." | 1.62 | Optimized protocol for an inducible rat model of liver tumor with chronic hepatocellular injury, inflammation, fibrosis, and cirrhosis. ( Chen, Z; Han, L; He, X; Li, S, 2021) |
| "In in vitro and in vivo hepatocellular carcinoma mouse models it can significantly suppress primary tumor growth, prevent distant metastasis/cell migration, reduce angiogenesis, and normalize the immunosuppressive tumor microenvironment by reducing tumor-associated macrophages (TAMs) infiltration, reprogramming TAMs toward an immunostimulatory phenotype and promoting cytotoxic T cell infiltration into tumor." | 1.62 | A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment. ( Chang, CC; Chen, Y; Chou, MC; Dinh, TK; Huang, JK; Huang, KW; Jan, JJ; Ke, YY; Lee, CJ; Shia, KS; Shiue, TY; Song, JS; Sung, YC; Ta, YN; Wu, CH; Yeh, KC; Yeh, TK, 2021) |
| "Liver cancer was induced in mice with hepatocyte-specific disruption of Myc and control mice by administration of diethylnitrosamine." | 1.62 | Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. ( Cai, J; Chen, L; Gao, Y; Gonzalez, FJ; Guo, X; Jiang, J; Krausz, KW; Liu, W; Luo, Y; Qu, A; Sun, L; Takahashi, S; Tang, W; Wang, Y; Xie, C; Yang, S; Yang, Y, 2021) |
| "We compared gene expression profiles of Morris Hepatoma (MH3924a) and DEN (diethylnitrosamine)-induced HCC models to those of liver tissues from normal and rapidly regenerating liver models, and performed gain- and loss-of-function studies of the identified gene targets for their roles in cancer cell proliferation in vitro and in vivo." | 1.56 | Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis. ( Chow, P; Denil, S; Ding, Z; Ericksen, RE; Escande-Beillard, N; Gruenewald, S; Haegebarth, A; Han, W; Lee, QY; Loh, A; Reversade, B; Steckel, M; Toh, HC; Wai Ho, TS, 2020) |
| "All mice administered oral DEN developed liver fibrosis, liver cirrhosis and hepatocellular carcinoma (HCC)." | 1.56 | Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis. ( Bai, L; Chen, Q; Jiang, S; Lai, J; Yang, W; You, X; Zhang, H, 2020) |
| " Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation." | 1.56 | Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020) |
| "And Wrh-f2 developed stable pulmonary metastasis." | 1.56 | Establishment of rat liver cancer cell lines with different metastatic potential. ( Feng, X; Hou, J; Liu, SF; Song, L; Zhang, HL; Zhang, JG; Zheng, L, 2020) |
| "Follow-up screening was performed in hepatocellular carcinoma with a focused CRISPR library targeting imaging-related genes." | 1.56 | Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer. ( Ackerman, D; Gade, TPF; Johnson, O; Mercadante, M; Perkons, NR; Pilla, G; Profka, E, 2020) |
| "Diethylnitrosamine was widely employed as a carcinogenic agent to stimulate the cancer in animal models." | 1.56 | Vicenin-2 Treatment Attenuated the Diethylnitrosamine-Induced Liver Carcinoma and Oxidative Stress through Increased Apoptotic Protein Expression in Experimental Rats. ( Bolla, SR; Chen, Y; Gong, G; Li, Y; Veeraraghavan, VP; Xu, C; Zhang, C; Zhang, M, 2020) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 1.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| "Treatment of DEN-induced hepatocellular carcinoma Wistar rats with the extract caused significant (p < 0." | 1.56 | Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats. ( Adebayo, AH; Adelani, IB; Adesina, GO; Edokwe, CB; Metibemu, DS; Oseha, OE; Yakubu, OF, 2020) |
| "Lactoferrin (Lf) has been reported for its inhibition of tumor growth and metastasis, however, the mechanism is not completely understood." | 1.51 | Regulation of PKB/Akt-pathway in the chemopreventive effect of lactoferrin against diethylnitrosamine-induced hepatocarcinogenesis in rats. ( Abdel-Rahman, RF; Hassan, AM; Hegazy, RR; Mansour, DF; Salama, AA, 2019) |
| "Echinacoside (ECH) is a phenylethanoid glycoside extracted from a Chinese herbal medicine, Cistanches salsa." | 1.51 | Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells. ( Ni, J; Song, Y; Wang, G; Xia, W; Ye, Y; Zhuang, J, 2019) |
| "Hesperidin is a flavanone glycoside that is found in the Citrus species and showed antioxidant, hepatoprotective as well as anticancer activity." | 1.51 | Involvement of PI3K/Akt pathway in the protective effect of hesperidin against a chemically induced liver cancer in rats. ( Hussein, RM; Kandeil, MA; Mo'men, YS, 2019) |
| "Hepatocellular carcinoma is the most frequent kind of primary liver cancer and occurs mostly in patients with chronic liver disease and cirrhosis." | 1.51 | Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway. ( Cui, G; Shang, X; Wang, N; Yang, G; Zhao, H; Zhao, L, 2019) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 1.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "In diethylnitrosamine (DEN)-treated primary hepatocytes, NAC and Trolox alleviated DNA damage by activating ataxia-telangiectasia mutated (ATM)/ATM and Rad3-related (ATR) for DNA repair whereas SS-31 and Mito-Q aggravated damage by inactivating them." | 1.48 | Contradictory effects of mitochondria- and non-mitochondria-targeted antioxidants on hepatocarcinogenesis by altering DNA repair in mice. ( Chen, Y; Fu, J; Qin, W; Wang, B; Wang, H; Xu, A; Yang, Z; Yu, T, 2018) |
| "Hepatocellular carcinoma is a common primary malignancy of hepatocytes that has caused many fatalities globally." | 1.48 | Inhibitory effects of mushroom extracts on progression of carcinogenesis in mice. ( Omwandho, C; Wasonga, C, 2018) |
| "The urgent unmet need for hepatocellular carcinoma (HCC) therapies is addressed here by characterising a novel mouse model of HCC in the context of ongoing liver damage and overnutrition." | 1.48 | Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma. ( Chen, J; Gorrell, MD; Henderson, JM; Kench, JG; McCaughan, GW; Polak, N; Roediger, B; Weninger, W; Zhang, HE, 2018) |
| "Hepatic cancer is well known, and leading cancer around the world and remain asymptomatic diseases." | 1.48 | Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles. ( Falls, N; Kumar, V; Ramteke, PW; Singh Dangi, D; Singh, D; Singh, M; Verma, A; Yadav, E, 2018) |
| "Both incidence and death rate due to liver cancer have increased in the United States." | 1.48 | Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes. ( Aizawa, K; Fu, M; Hiroyuki, S; Hu, KQ; Li, CC; Liu, C; Takahashi, S; Wang, XD; Wu, G; Xia, H; Zhao, L, 2018) |
| "The adenosine derivative treatment reduced diethylnitrosamine-induced collagen expression and decreased the proportion of nodules positive for the tumor marker γ-glutamyl transferase." | 1.46 | Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats. ( Chagoya de Sánchez, V; Pérez-Carreón, JI; Pérez-Martínez, L; Velasco-Loyden, G; Vidrio-Gómez, S, 2017) |
| "Blocking lipogenesis in cultured liver cancer cells is sufficient to decrease cell viability; however, it is not known whether blocking lipogenesis in vivo can prevent liver tumorigenesis." | 1.46 | Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. ( Breen, DS; Byrne, FL; Caldwell, SH; Chow, JD; Cooney, GJ; Hargett, SR; Hoehn, KL; James, DE; Lackner, C; Lahiri, S; Nelson, ME; Olzomer, EM; Slack-Davis, JK; Turner, N; Wu, LE, 2017) |
| "While gender differences in hepatocellular carcinoma (HCC) are profound, the mechanism is unclear." | 1.43 | Testosterone regulation of cyclin E kinase: A key factor in determining gender differences in hepatocarcinogenesis. ( Barn, VA; Blackburn, AC; Board, P; Farrell, GC; Pok, S; Teoh, NC; Wong, HJ, 2016) |
| "Hepatocellular carcinoma is increasingly important in the United States as the incidence rate rose over the last 30 years." | 1.43 | DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status. ( Drinkwater, NR; Hanes, MA; Herbert, DC; Herzig, MC; Hildreth, K; McMahan, CA; Reddick, RL; Reddick, T; Street, K; Walter, CA; Zavadil, JA, 2016) |
| "The development of hepatocellular carcinoma (HCC) is a common consequence of advanced liver fibrosis but the interactions between fibrogenesis and carcinogenesis are still poorly understood." | 1.43 | TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver. ( Bohner, A; Dapito, DH; Lammert, F; Schwabe, RF; Weber, SN, 2016) |
| "Dieckol (DEK) is a naturally occuring phlorotannins found in marine brown algae Ecklonia cava which is attributed with various pharmacological properties." | 1.43 | Protective effects of dieckol on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. ( Duraikannu, A; Fredrick, WS; Kodisundaram, P; Ravichandran, S; Sadeeshkumar, V; Sivaperumal, R, 2016) |
| "After 4 or 13 weeks of IMA treatment, liver hypertrophy was observed at the tumor-inducible dose without differences among genotypes or durations." | 1.43 | A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice. ( Inoue, K; Kodama, Y; Matsuo, S; Takahashi, M; Tamura, K; Yoshida, M, 2016) |
| "Diethylnitrosamine (DEN) was used to induce pre-carcinoma and early HCC nodules in the experimental group." | 1.43 | Detection and differentiation of early hepatocellular carcinoma from cirrhosis using CT perfusion in a rat liver model. ( Feng, GL; Jiang, HJ; Li, DQ; Li, JP; Wan, Y; Wang, HB; Zhao, DL, 2016) |
| "Curcumin treatment partially reversed DENA-induced damage as it reduced the overexpression of the angiogenic and anti-apoptotic factors TGF-β and Akt and improved caspase-3 expression." | 1.42 | Curcumin ameliorate DENA-induced HCC via modulating TGF-β, AKT, and caspase-3 expression in experimental rat model. ( Abd El-Aziz, EA; Abd El-Aziz, HO; Abd El-Ghany, AA; Abdel Aziz, MA; Abouzied, MM; Ahmed, NS; Eltahir, HM, 2015) |
| "At present, the treatment of hepatocellular carcinoma (HCC) is an international problem." | 1.42 | Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Chen, Q; Li, Y; Liu, W; Tang, H; Yang, X; Zhao, X, 2015) |
| "We found that loss of MnSOD in hepatoma cells contributed to their conversion toward a more malignant phenotype, affecting all cellular properties generally associated with metabolic transformation and tumorigenesis." | 1.42 | Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. ( Dombrowski, F; Görlach, A; Jakupovic, M; Kietzmann, T; Konzack, A; Kubaichuk, K; Miinalainen, I; Sormunen, R, 2015) |
| "Diethylnitrosamine (DEN) was adopted to induce hepatic precancerous model in mice through intraperitoneal injection, and prevention efficacy of TMPZ at a dose of 162 mg/kg was examined by liver histological analysis and activities of serum marker enzymes." | 1.40 | Pharmacokinetic variations of tetramethylpyrazine phosphate after oral administration in hepatic precancerous mice and its hepatoprotective effects. ( Cai, D; Feng, L; Jiao, Y; Liu, X; Mao, W; Wang, X; Wang, Y; Zhang, D; Zhang, J; Zhao, X, 2014) |
| "Carvacrol is a predominant monoterpenoic phenol believed to impede cancer promotion and progression." | 1.40 | Carvacrol modulates instability of xenobiotic metabolizing enzymes and downregulates the expressions of PCNA, MMP-2, and MMP-9 during diethylnitrosamine-induced hepatocarcinogenesis in rats. ( Balan, R; Krishnan, G; Mani, GK; Mgj, D; Ramalingam, S; Ramasamy, E; Subramaniyan, J; Thandavamoorthy, P; Thiruvengadam, D; Veerabathiran, R, 2014) |
| "Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis." | 1.40 | The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014) |
| "Interestingly, HFD, which induced hyperlipidemia and hepatic steatosis, attenuated DEN-related malnutrition and fibrosis progression in HFD + DEN group during 10-14 weeks." | 1.40 | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. ( Ding, WJ; Duan, XY; Fan, JG; Pan, Q; Qiao, L; Yan, SY, 2014) |
| "Molecular mechanisms responsible for hepatocellular carcinoma (HCC) remain largely unknown." | 1.40 | Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. ( Bakiri, L; Djouder, N; Gomes, AL; Graña, O; Pisano, DG; Rodriguez-Justo, M; Ruppen, I; Sheshappanavar, V; Tummala, KS; Wagner, EF; Ximénez-Embún, P; Yilmaz, M, 2014) |
| "The ability to treat hepatocellular carcinoma was measured by comparing biochemical serum markers such as serum alanine aminotransferase, serum aspartate aminotransferase, serum alkaline phosphatase, and the specific marker for hepatocellular carcinoma, alpha fetoprotein." | 1.39 | Anticancer effect of ursolic acid stearoyl glucoside in chemically induced hepatocellular carcinoma. ( Afzal, M; Ahmad, A; Al-Abbasi, FA; Anwar, F; Kazmi, I; Narooka, AR; Singh, R, 2013) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 1.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| "In human hepatocellular carcinoma tumors, high levels of CXCR4 always correlated with activation of the TGF-β pathway, a less differentiated phenotype, and a cirrhotic background." | 1.39 | Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells. ( Bertran, E; Caja, L; Crosas-Molist, E; Egea, G; Fabregat, I; Lastra, R; Lopez-Luque, J; Navarro, E; Ramos, E; Sancho, P; Serrano, T, 2013) |
| "Lycopene, is a well known antioxidant and have promising preventive potentials, however the mechanism of action remain hypothetical and unclear." | 1.39 | Lycopene modulates initiation of N-nitrosodiethylamine induced hepatocarcinogenesis: studies on chromosomal abnormalities, membrane fluidity and antioxidant defense system. ( Bansal, MP; Gupta, P; Koul, A, 2013) |
| "Liver cancer, predominantly hepatocellular carcinoma (HCC), represents a complex and fatal malignancy driven primarily by oxidative stress and inflammation." | 1.39 | Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis. ( Bhatia, D; Bishayee, A; Darvesh, AS; Meszaros, JG; Ohanyan, V; Thoppil, RJ, 2013) |
| "It is considered that diethylnitrosamine (DENA) is metabolized mostly in the liver with producing highly reactive compounds alkylating cellular macromolecules and causing toxic and carcinogenic effects." | 1.38 | [Increase of general toxic effects and decrease of hepatocarcinogenic effects of diethylnitrosamine administered to mice in conjunction with isopropanol]. ( Baginskaia, NV; Il'nitskaia, SI; Kaledin, VI; Ovchinnikova, LP; Vasiunina, EA, 2012) |
| "Diethylnitrosamine (DEN) is a well known carcinogenic substance, which induces hepatic carcinoma." | 1.38 | Anticarcinogenic activity of nanoencapsulated quercetin in combating diethylnitrosamine-induced hepatocarcinoma in rats. ( Das, N; Ghosh, A; Ghosh, D; Mandal, AK; Sarkar, S; Thakur Choudhury, S, 2012) |
| "Hepatocellular carcinoma was induced in animals of groups II and III with 0." | 1.38 | Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced hepatocellular carcinoma. ( Devaraj, SN; Shilpa, PN; Venkatabalasubramanian, S, 2012) |
| "Diethylnitrosamine metabolism was measured based on nitrite formation and liver histology using GGT histochemistry." | 1.38 | Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis. ( Beltrán-Ramírez, O; Pérez, RM; Sierra-Santoyo, A; Villa-Treviño, S, 2012) |
| "Pretreatment with bicyclol showed a marked reduction in the above condition." | 1.38 | A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model. ( Liu, G; Sun, H; Wei, H; Yu, L, 2012) |
| " In Experiment 2, the same experiment as Experiment 1 was performed, but the dosage of OPZ was 0 or 276 mg/kg." | 1.38 | Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action. ( Hayashi, H; Ishii, Y; Mitsumori, K; Morita, R; Shibutani, M; Shimamoto, K; Suzuki, K; Taniai, E, 2012) |
| "Treatment with myrtenal to cancer bearing animals resulted in remarkable increase in the inherent antioxidants and excellent modulation in the proteins of apoptotic and anti-apoptotic cascade." | 1.38 | Myrtenal attenuates diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades. ( Balasubramanian, MP; Hari Babu, L; Perumal, S, 2012) |
| "Patients with liver cirrhosis and HCC had significantly increased serum endotoxin levels." | 1.38 | Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. ( Chen, HY; Dai, RY; He, YQ; Li, YQ; Li, Z; Lin, Y; Liu, Q; Qiu, BJ; Shan, L; Tan, YX; Tang, L; Wang, C; Wang, HY; Wu, FQ; Wu, H; Yan, HX; Yang, W; Yu, LX; Zhai, B; Zhang, HL; Zheng, LY, 2012) |
| "Hepatocellular carcinoma was induced by single intraperitoneal injection of N-nitrosodiethylamine (NDEA) in normal saline at a dose of 200 mg/kg body weight followed by weekly subcutaneous injections of CCl(4)(3 mL/kg/week) for 6 weeks, as the promoter of carcinogenic effect." | 1.38 | Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl4-induced hepatocellular carcinoma in Wistar rats. ( Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M, 2012) |
| "Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC)." | 1.38 | Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. ( Chen, C; Ding, J; Feng, GS; Han, T; Huang, L; Li, Z; Ning, BF; Sun, W; Wang, C; Wang, HY; Wen, W; Wu, K; Wu, MC; Xie, WF; Yang, W, 2012) |
| "Pinocembrin was neither mutagenic nor carcinogenic in rat liver, and neither inhibited nor prevented micronucleus formation as well as GST-P positive foci formation induced by diethylnitrosamine." | 1.38 | Effects of pinocembrin on the initiation and promotion stages of rat hepatocarcinogenesis. ( Fukushima, S; Pompimon, W; Punvittayagul, C; Wanibuchi, H; Wongpoomchai, R, 2012) |
| "A genetic basis of hepatocellular carcinoma (HCC) has been well-established and major signaling pathways, such as p53, Wnt-signaling, transforming growth factor-β (TGF-β) and Ras pathways, have been identified to be essential to HCC development." | 1.37 | Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis. ( Galle, PR; Hansen, T; Kanzler, S; Longerich, T; Maass, T; Mann, A; Schirmacher, P; Strand, D; Teufel, A; Thieringer, FR, 2011) |
| " At day 0, the fertilized eggs of the dosed groups were injected with 1 (LD) or 4 (HD) mg/egg (about 12." | 1.37 | Production of liver preneoplasia and gallbladder agenesis in turkey fetuses administered diethylnitrosamine. ( Brunnemann, KD; Enzmann, HG; Iatropoulos, MJ; Smart, DJ; Williams, GM, 2011) |
| "Quercetin is an antioxidant flavonoid, found ubiquitously in nature and extensively used in herbal medicines and food additives." | 1.37 | Quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in rats. ( Gupta, C; Jena, GB; Ramarao, P; Tripathi, DN; Vikram, A, 2011) |
| " In the present study, the authors treated C57BL/6 mice with 25, 50, and 75 mg/kg of diethylnitrosamine (DEN) for 4 or 8 weeks by intraperitoneal injection to investigate the dose-response pattern of preneoplastic and neoplastic lesion formation in the liver." | 1.37 | Dose-related induction of hepatic preneoplastic lesions by diethylnitrosamine in C57BL/6 mice. ( Kamendulis, LM; Klaunig, JE; Kushida, M; Peat, TJ, 2011) |
| "Phosphorylated STAT3 was found in human hepatocellular carcinoma tissue samples and was expressed in tumor cells and also in monocytes." | 1.37 | STAT3 activation in monocytes accelerates liver cancer progression. ( Li, J; Meng, XL; Wu, WY; Wu, ZS; Zhang, CL, 2011) |
| " Using this model, we investigated the efficacy of an equivalent dosage of dietary LY from either a pure compound or a tomato extract (TE) against NASH-promoted hepatocarcinogenesis." | 1.36 | Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. ( Ausman, LM; Greenberg, AS; Russell, RM; Wang, XD; Wang, Y, 2010) |
| "Recent studies have demonstrated that frequent, low-dose metronomic (MET) dosing of cytotoxic agents may not only be as efficient as conventional maximum tolerated dose (MTD) chemotherapy but also less toxic." | 1.36 | Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis. ( Bae, SH; Choi, JY; Hur, W; Jang, JW; Kim, GD; Kim, JD; Kwon, JH; Park, JA; Park, ST; Woo, HY; Yoo, CR; Yoon, SK, 2010) |
| "Morin was also found to prevent the Akt-mediated suppression of GSK-3beta possibly causing cell cycle arrest at the G1/S phase." | 1.36 | Morin fosters apoptosis in experimental hepatocellular carcinogenesis model. ( Devaraj, SN; Sivaramakrishnan, V, 2010) |
| " To induce hepatocarcinoma, groups II-V rats received diethylnitrosamine solution (100mg/L) at the dosage of 10mg/kg body weight in drinking water daily for 16 weeks, followed by sterilized water for a further 2 weeks." | 1.36 | Effect of selenium-enriched malt on VEGF and several relevant angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. ( Liu, JG; Liu, YJ; Wang, XL; Zhao, HJ, 2010) |
| "Diethylnitrosamine (DEN) is a representative chemical carcinogen with the potential to cause tumors in various organs, including the liver, skin, gastrointestinal tract, and respiratory system." | 1.35 | Diethylnitrosamine (DEN) induces irreversible hepatocellular carcinogenesis through overexpression of G1/S-phase regulatory proteins in rat. ( Jang, JJ; Lee, MJ; Li, L; Park, DH; Park, SK; Seo, JN; Shin, JW, 2009) |
| "Ursolic acid is a natural triterpenoid widely found in food, medicinal herbs, apple peel and other products it has been extensively studied for its anticancer and antioxidant properties." | 1.35 | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2009) |
| "In the liver cirrhosis and liver cancer group, Mphi had more prominences, meanwhile much more mitochondria, ribosome, rough endoplasmic reticulum, lysosome can be found in the cytoplasm, especially in the liver cancer group." | 1.35 | Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats. ( Huang, C; Li, ZF; Liu, ZW; Pan, D; Zhang, S; Zhou, R, 2009) |
| "Cotreatment with morin prevented the elevation of marker enzymes induced by N-nitrosodiethylamine." | 1.35 | Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin. ( Niranjali Devaraj, S; Praveen Kumar, VR; Shilpa, PN; Sivaramakrishnan, V, 2008) |
| "Diethylnitrosamine (DEN) is a known carcinogen that can alkylate DNA molecules." | 1.35 | Two-dimensional differential gel electrophoresis/analysis of diethylnitrosamine induced rat hepatocellular carcinoma. ( Chan, CY; Chen, X; Kung, HF; Lai, L; Li, D; Lin, MC; Qi, Y; Yew, DT; Yu, F; Yuan, C, 2008) |
| "Recently, human non-alcholic steatohepatitis (NASH) has been focused of attention regarding hepatocellular carcinoma." | 1.34 | High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice. ( Fukushima, S; Hagihara, A; Iwai, S; Makino, S; Min, W; Mori, S; Morimura, K; Murai, T; Seki, S, 2007) |
| "5 ppm vanadium is potentially and optimally effective, as derived from dose-response studies, in limiting early molecular events and preneoplastic lesions, thereby modulating the initiation stage of hepatocarcinogenesis." | 1.34 | Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Dhachinamoorthi, D; Kumar P, A; Rana, A, 2007) |
| "Cyclohexanol is a basic industrial chemical widely used because of its versatility as an industrial solvent." | 1.34 | Co-carcinogenic effect of cyclohexanol on the development of preneoplastic lesions in a rat hepatocarcinogenesis model. ( Alemán-Lazarini, L; Arce-Popoca, E; Cabrales-Romero, Mdel P; Carrasco-Legleu, CE; Fatel-Fazenda, S; Márquez-Rosado, L; Sierra-Santoyo, A; Trejo-Solís, C; Villa-Treviño, S, 2007) |
| "Clofibric acid (CLO) is a nongenotoxic hepatocarcinogen in rodents that causes altered hepatocellular foci and/or neoplasms." | 1.34 | Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat. ( Boitier, E; Desdouets, C; Isaacs, KR; Michel, C; Roberts, RA; Slaoui, M, 2007) |
| "Diethylnitrosamine (DEN) was used as cancer-inducing agent in the experimental animals." | 1.34 | Potential of Vinca rosea extracts in modulating trace element profile: a chemopreventive approach. ( Boruah, M; Chakraborty, A; Mohanta, B; Sudarshan, M, 2007) |
| "The number of hepatocellular carcinomas (HCCs) was significantly increased in Tg compared with non-Tg rats." | 1.34 | Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication. ( Asamoto, M; Futakuchi, M; Hokaiwado, N; Ogawa, K; Shirai, T; Takahashi, S, 2007) |
| "N-diethylnitrosamine is an important carcinogen used in liver cancer animal models." | 1.33 | Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis. ( Alemán-Lazarini, L; Carrasco-Legleu, C; García-Cuellar, C; Hernández-García, S; Pérez-Carreón, J; Salcido-Neyoy, M; Sánchez-Pérez, Y; Villa-Treviño, S, 2005) |
| " PB produced a twofold increase in liver MF over controls after 27 weeks of treatment, but a similar increase was not observed with longer dosing times; at later time points, the MF in the PB groups was lower than that of the control group, suggesting that PB is not producing direct DNA damage in the liver." | 1.33 | Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice. ( de Boer, J; Fairchild, D; Glickman, B; Johnson, A; Kanazawa, N; Mirsalis, JC; Nguyen, T; Shimon, JA; Winegar, RA, 2005) |
| "Diethylnitrosamine was administrated to 15-day-old wild-type and bid-null mice." | 1.33 | Deletion of Bid impedes cell proliferation and hepatic carcinogenesis. ( Bai, L; Chen, X; DiFrancesca, D; Ni, HM; Yin, XM, 2005) |
| "Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of beta1-ARs, extensive areas completely devoid of beta1-ARs being mingled with areas showing a weak immunostaining." | 1.33 | Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats. ( Cardani, R; Zavanella, T, 2005) |
| "05 ppm, caused significant reduction, showing a J-shape dose-response curve." | 1.33 | Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes. ( Fukushima, S; Funae, Y; Kinoshita, A; Mitsuru, F; Morimura, K; Oka, M; Puatanachokchai, R; Wanibuchi, H; Yamaguchi, S, 2006) |
| "Value of spin states ratio in hepatoma was shown to be greater then in liver." | 1.33 | [Ratio of low- and high-spin cytochrome P-450 in liver microsomes of N-nitrosodiethylamine-induced hepatomas]. ( Mel'nykov, OR; Momot, VIa; P'iatchanina, TV; Sydoryk, IeP, 2005) |
| "Treatment with Curcumin (100 mg kg(-1)body wt) and Embelin (50 mg kg(-1)body wt) prevented the drop in hepatic glutathione antioxidant defense, decreased lipid peroxidation, minimized the histological alterations induced by DENA/PB, but showed toxic effects on the hematopoietic cells." | 1.33 | Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats. ( Bali, G; Sreepriya, M, 2006) |
| "Vanadium treatment also inhibited DPCs (P<0." | 1.33 | Molecular basis of anticlastogenic potential of vanadium in vivo during the early stages of diethylnitrosamine-induced hepatocarcinogenesis in rats. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Ghosh, B; Pandey, N; Rana, B, 2006) |
| "As tumors progressed to hepatocellular carcinomas, the additional Tg FoxM1B protein had no effect on cell proliferation, and there was no increase in tumor burden compared to wild-type animals." | 1.32 | Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions. ( Adami, GR; Costa, RH; Kalinin, SA; Kalinina, OA; Mikaelian, I; Panda, S; Polack, EW, 2003) |
| "Although no lung metastasis was observed in the rats killed at the end of the period of carcinogen exposure, lung metastasis was found in 100% of animals in all the groups at the end of the experiment." | 1.32 | Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma. ( Futakuchi, M; Ogawa, K; Shirai, T; Takahashi, S; Tamano, S, 2004) |
| "Kojic acid (KA) has been used as a food additive for preventing enzymatic browning of crustaceans and as a cosmetic agent for skin whitening." | 1.32 | Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine. ( Hirose, M; Imai, T; Izumi, K; Mitsumori, K; Onose, J; Takizawa, T; Tamura, T; Ueda, M, 2004) |
| "The question whether hepatocellular carcinoma (HCC) arises from dedifferentiation of mature hepatocytes or from proliferation of liver stem cells is still debated." | 1.31 | Demonstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats. ( Bralet, MP; Ferry, N; Pichard, V, 2002) |
| "Phenobarbital (PB) is an antiepileptic drug that promotes hepatocarcinogenesis in rodents when administered subsequent to an initiating carcinogen like N-nitrosodiethylamine (DEN)." | 1.31 | Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. ( Buchmann, A; Gaunitz, F; Gebhardt, R; Kurek, R; Loeppen, S; Schneider, D; Schwarz, M, 2002) |
| " Three weeks after DEN treatment, Fas-mediated liver cell apoptosis induced by anti-Fas antibody resulted in a biphasic effect on induction of liver cell tumours, depending on dosage and time of antibody administration." | 1.31 | Effects of Fas-mediated liver cell apoptosis on diethylnitrosamine-induced hepatocarcinogenesis in mice. ( Hara, A; Kawabata, K; Matsunaga, K; Mori, H; Sugie, S; Yamada, Y; Yoshimi, N, 2000) |
| "Curcumin has been widely used as a spice and coloring agent in foods." | 1.31 | Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. ( Chen, CR; Cheng, AL; Chuang, SE; Hsieh, CY; Hsu, CH; Kuo, ML; Lai, GM; Lin, JK, 2000) |
| " These rats had been treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) under different dosing regimens, but we used the same administered biweekly dose of 1." | 1.31 | Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. ( Lucier, GW; Portier, CJ; Sills, RC; Tritscher, AM; Walker, NJ, 2000) |
| "Coumaperine has been isolated from white pepper as a naturally occurring antioxidative agent, but its potential modifying effects on carcinogenesis remain unclear." | 1.31 | Chemopreventive effects of coumaperine from pepper on the initiation stage of chemical hepatocarcinogenesis in the rat. ( Fukushima, S; Funae, Y; Hayashi, S; Imaoka, S; Kikuzaki, H; Kitano, M; Nakatani, N; Wanibuchi, H, 2000) |
| "Diethylnitrosamine-treated TT mice developed both preneoplastic and neoplastic lesions in the liver." | 1.31 | Enhancement of chemical hepatocarcinogenesis by the HIV-1 tat gene. ( Altavilla, G; Barbanti-Brodano, G; Caputo, A; Corallini, A; Lanfredi, M; Piola, C, 2000) |
| "Vanadium (V) has recently been found to possess potent anti-neoplastic activity in rat hepatocarcinogenesis." | 1.31 | Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3). ( Basak, R; Chatterjee, M; Saha, BK, 2000) |
| "Nitroglycerin was active to enhance transduction of large tumors with trabecular or pseudoglandular histological pattern, which were impermeable to adenoviral vectors even after histamine or angiotensin treatments." | 1.31 | A blood-tumor barrier limits gene transfer to experimental liver cancer: the effect of vasoactive compounds. ( Alzuguren, P; Bilbao, R; Bustos, M; Drozdzik, M; Pajares, MJ; Prieto, J; Qian, C, 2000) |
| "In gene therapy for hepatocellular carcinoma (HCC), gene transfer is efficient for small tumors, but not for large tumors." | 1.31 | Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters. ( Eto, Y; Futagawa, Y; Ohashi, T; Okamoto, T; Shiba, H, 2001) |
| "Phenobarbital (PB) is an antiepileptic drug which promotes hepatocarcinogenesis in rodents when administered subsequent to an initiating carcinogen like diethylnitrosamine (DEN)." | 1.31 | Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. ( Aydinlik, H; Buchmann, A; Moennikes, O; Nguyen, TD; Schwarz, M, 2001) |
| "In normal (nonlesion) liver, vitamin E deficiency (0 mg/kg diet) increased hepatic DNA synthesis." | 1.30 | Vitamin E modulation of hepatic focal lesion growth in mice. ( Klaunig, JE; Kolaja, KL, 1997) |
| "Transforming growth factor beta-1 (TGF-beta1) is a potent inhibitor of hepatocyte growth both in vivo and in vitro." | 1.30 | Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice. ( Factor, VM; Jensen, MR; Kao, CY; Santoni-Rugiu, E; Thorgeirsson, SS; Woitach, JT, 1997) |
| " Our observations indicate that long term administration of I3C in the diet inhibits DEN-initiated hepatocarcinogenesis in the infant mouse model." | 1.30 | Long term dietary indole-3-carbinol inhibits diethylnitrosamine-initiated hepatocarcinogenesis in the infant mouse model. ( Hendricks, JD; Oganesian, A; Williams, DE, 1997) |
| "Phenobarbital treatment increased the number of CYP2A5-positive centrilobular hepatocytes and the CYP2A5-positive areas were extended into the middle zone in all strains, but periportal hepatocytes remained negative." | 1.30 | Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions. ( Bursch, W; Camus-Randon, AM; Grasl-Kraupp, B; Lang, MA; Rossmanith, W; Schulte-Hermann, R; Wastl, UM, 1998) |
| "The average score of liver cirrhosis associated with HCV was 1." | 1.30 | Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. ( Hino, S; Kamahora, T; Kawasaki, H; Miyata, H; Shimada, A; Shiota, G; Shiraki, K; Terada, T, 1998) |
| " Female Sprague-Dawley rats were dosed with diethylnitrosamine (15 mg/kg) at 24 h of age." | 1.30 | Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. ( Chen, HW; Ko, JJ; Lii, CK, 1998) |
| "Trichloroethylene (TCE) was found as a contaminant in the well supplying water to an aquatic testing laboratory." | 1.30 | Environmental complex mixture toxicity assessment. ( Boncavage-Hennessey, EM; Brennan, LM; Gardner, HS; Rosencrance, AB; Toussaint, MW; Wolfe, MJ, 1998) |
| "Dicamba alone did not increase the number or volume of these altered hepatic foci." | 1.30 | Promoting activity of the herbicide dicamba (2-methoxy-3, 6-dichlorobenzoic acid) in two stage hepatocarcinogenesis. ( Espandiari, P; Glauert, HP; Lee, EY; Robertson, LW, 1999) |
| "Diethylnitrosamine (50mg/L) was administered to 39 rats for 10 weeks; liver tissue was obtained at weeks 10, 16 and 19." | 1.30 | Macrophage and hepatic stellate cell responses during experimental hepatocarcinogenesis. ( Burr, AW; Burt, AD; Dack, CL; Johnson, SJ; Mathew, J; Toole, K, 1998) |
| "The most common form of metastasis was trans-coelomic, followed by direct invasion and distant metastasis, presumably via the vascular route." | 1.30 | Progression of hepatic neoplasia in medaka (Oryzias latipes) exposed to diethylnitrosamine. ( Hinton, DE; Okihiro, MS, 1999) |
| "8-fold increased over controls in the TCDD group with waiting period compared to a 4-fold increase over controls at the end of the 30 week dosing period." | 1.29 | Persistence of TCDD-induced hepatic cell proliferation and growth of enzyme altered foci after chronic exposure followed by cessation of treatment in DEN initiated female rats. ( Clark, GC; Lucier, GW; Maronpot, R; Sewall, C; Sills, RC; Tritscher, AM, 1995) |
| "Deferoxamine (DFO) is an iron chelating agent and has been known to have an antiproliferative effect in various malignant cells including hepatocellular carcinoma and the effect seems to be related to depletion of iron." | 1.29 | The effect of deferoxamine on the preneoplastic lesions in the chemically induced hepatocarcinogenesis. ( Jung, WH; Park, C; Park, YN, 1994) |
| "Propranolol is a lipophilic non-selective beta-blocker mainly eliminated via the liver; atenolol is a hydrophilic beta 1-selective blocking agent, mainly eliminated via the kidney." | 1.29 | Evaluation of the tumor-promoting activity of two beta-adrenoreceptor blocking agents, propranolol and atenolol, in liver of Fischer 344 rats. ( Ameri, L; Arias, E; Girotti, P; Mazzoleni, G; Presta, M; Radaelli, G; Ragnotti, G; Zavanella, T, 1994) |
| " In contrast, the dose-response curve observed for DEN-treated rats 18 weeks after carcinogen administration was similar to that observed 2 weeks after carcinogen treatment for both phenobarbital- and non-phenobarbital-treated rats." | 1.29 | Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats. ( Baker, K; Campbell, HA; Dragan, YP; Mass, M; Pitot, HC; Vaughan, J, 1994) |
| " The dose-response curve for fish maintained an additional 6 months postexposure was shifted toward higher incidence but was parallel to the curve for fish killed at cessation of exposure." | 1.29 | Dose-dependent carcinogenicity and frequent Ki-ras proto-oncogene activation by dietary N-nitrosodiethylamine in rainbow trout. ( Bailey, GS; Cheng, R; Hendricks, JD; Pereira, CB; Shelton, DW, 1994) |
| " In Experiment 2, a total of 45 female SD rats were dosed with DEN (100 mg/kg, i." | 1.29 | Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats. ( Ahn, B; Bae, JH; Han, BS; Jang, JJ; Kim, DJ; Lee, KK, 1994) |
| "The dose-response characteristics of initiation of hepatocarcinogenesis by diethylnitrosamine (DEN) was investigated in the neonatal female rat by means of the quantitative stereologic estimation of altered hepatic foci (AHF) expressing multiple markers." | 1.29 | The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats. ( Dragan, YP; Pitot, HC; Xu, YH, 1993) |
| "Phenobarbital (PB) is a potent tumor promoter in rodent liver." | 1.29 | Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels. ( Boyer, IJ; De Souza, AT; Hankins, GR; Jirtle, RL; Mansbach, JM; Mills, JJ, 1996) |
| " We conclude that long term intake of BC could reduce cancer risk by preventing hepatic lipid peroxidation and RBC membrane protein damage due to its antioxidant actions." | 1.29 | Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis. ( Bishayee, A; Chatterjee, M; Sarkar, A, 1995) |
| "Hexachlorobenzene (HCB) is an important environmental contaminant derived mainly from industrial and agricultural sources." | 1.29 | Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene. ( Cabral, R; Hakoi, K; Hasegawa, R; Hoshiya, T; Ito, N, 1996) |
| "Diethylnitrosamine (DEN) was used as the initiating agent followed by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HCDD) as promoters." | 1.29 | Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. ( Bock, KW; Buchmann, A; Luebeck, EG; Moolgavkar, SH, 1996) |
| " In the present study we examined the dose-response effect of dieldrin (at several doses) on focal lesion growth (tumor promotion), hepatocyte apoptosis and DNA synthesis in rat and mouse liver." | 1.29 | Selective dieldrin promotion of hepatic focal lesions in mice. ( Klaunig, JE; Kolaja, KL; Stevenson, DE; Walborg, EF, 1996) |
| " Because the dose-response curves were considered non-linear for most nitrosamines, synergistic effects were not apparent for the 1/4 mixture." | 1.29 | Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat. ( Futakuchi, M; Hasegawa, R; Hirose, M; Ito, N; Lijinsky, W; Shirai, T, 1996) |
| "The dose-response of phenobarbital (PB) promotion of hepatocarcinogenesis in rats was investigated." | 1.28 | Threshold dose dependence in phenobarbital promotion of rat hepatocarcinogenesis initiated by diethylnitrosamine. ( Hayashi, Y; Maekawa, A; Matsushima, Y; Mitsumori, K; Ogasawara, H; Onodera, H, 1992) |
| " At dosage levels equimolar to 500 ppm PB, none of the three compounds promoted development of hepatocellular adenomas or carcinomas, in contrast to PB." | 1.28 | Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat. ( Diwan, BA; Henneman, JR; Lubet, RA; Nims, RW; Rice, JM; Ward, JM, 1992) |
| " The data indicate that at least in hepatocellular tumours of the C57Bl/10J strain and using chronic dosing regimes the ras genes do not represent markers for in vivo genotoxic activity." | 1.28 | Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours. ( Hardaker, KJ; Lord, PG; Loughlin, JM; Marsden, AM; Orton, TC, 1992) |
| " A major uncertainty in risk assessment for TCDD is the lack of adequate dose-response relationships following chronic exposure to TCDD." | 1.28 | Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. ( Clark, GC; Goldstein, JA; Lucier, GW; McCoy, Z; Portier, CJ; Tritscher, AM, 1992) |
| "Tamoxifen is a well-tolerated palliative and adjuvant treatment for human breast cancer and requires continuous, long-term administration for optimal therapeutic effectiveness." | 1.28 | Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis. ( Dragan, YP; Pitot, HC; Xu, YD, 1991) |
| "Groups of rats, either dosed with N-nitrosodiethylamine (NDEA) for 10 weeks (from the age of 7 to 17 weeks) or untreated, were fed diets containing either 2% (low fat, LF) or 30% polyunsaturated fat (high fat, HF) on an equicaloric basis from 5 weeks until rats were 43 weeks old." | 1.28 | Mechanisms of fat-related modulation of N-nitrosodiethylamine-induced tumors in rats: organ distribution, blood lipids, enzymes and pro-oxidant state. ( Ahotupa, M; Bartsch, H; Béréziat, JC; Bussacchini-Griot, V; Cabral, JR; Camus, AM; Hietanen, E; Laitinen, M; Wild, H, 1991) |
| "Second, we found that in microscopic hepatic neoplasms in B6C3F1 mice, the thymidine labeling indices were 2." | 1.28 | Growth kinetics of microscopic hepatocellular neoplasms in carcinogen-resistant and carcinogen-responsive strains of mice. ( Goldfarb, S; Pugh, TD, 1992) |
| " In order to show the usefulness of our assays, a preliminary study showing the ability of the immunobioassay to detect the expression of OFP in the plasma of carcinogen treated rats in a dosage dependent manner has been presented." | 1.28 | Development and use of monoclonal antibodies against an oncofetal protein associated with carcinogenesis and tumorigenesis. ( Larroya-Runge, SN; Runge, SW; Schumm, DE; Webb, TE, 1991) |
| " The principal aim was to characterize the dose-response relationship for the effects of these agents on esophageal cancer (NDEA) or on various types of liver cancer (NDEA and NDMA), although NDEA also caused a few tumors of the nasopharynx and NDMA also caused a few tumors of the lung." | 1.28 | Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose-response study. ( Brantom, P; Grasso, P; Gray, R; Peto, R, 1991) |
| " Studies of 16 different concentrations of N-nitrosopyrrolidine and N-nitrosopiperidine given from age 6 weeks onwards to small groups of rats yielded dose-response relationships for the effects of N-nitrosopyrrolidine on liver tumors and for those of N-nitrosopiperidine on tumors of the liver and upper gastrointestinal tract that resembled those seen for NDMA and NDEA, respectively, except that N-nitrosopyrrolidine and N-nitrosopiperidine were less potent [the respective dose rates needed to halve the proportion of tumorless survivors after 2 years of treatment being approximately 0." | 1.28 | Chronic nitrosamine ingestion in 1040 rodents: the effect of the choice of nitrosamine, the species studied, and the age of starting exposure. ( Brantom, P; Grasso, P; Gray, R; Peto, R, 1991) |
| "One of the critical issues in risk assessment for chemical carcinogens is the evaluation of dose-response relationships for tumor promoters." | 1.28 | Dose-response relationships in promotion of rat hepatocarcinogenesis by 17 alpha-ethinylestradiol. ( Campen, D; Lucier, G; Maronpot, R, 1990) |
| " Four-day-old female F344/N rats were dosed with diethylnitrosamine (10 mg/kg)." | 1.28 | Effects of alpha-tocopherol, phenobarbital, and butylated hydroxyanisole during promotion of diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Duitsman, P; Hendrich, S; Jackson, A; Krueger, SK; Myers, RK, 1991) |
| "15 mumol/kg body weight on day 1 after birth) followed by chronic administration of phenobarbital-sodium (PB; 0." | 1.28 | Phenobarbital enhances the formation of reactive oxygen in neoplastic rat liver nodules. ( Kunz, W; Scholz, W; Schütze, K; Schwarz, M, 1990) |
| "Chlordecone (Kepone) has been extensively studied for its toxicity in male production workers who were exposed to large quantities of this organochlorine pesticide." | 1.28 | Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence. ( Blanke, RV; Fitzgerald, R; Guzelian, PS; Sirica, AE; Wilkerson, CS; Wu, LL, 1989) |
| "diethylnitrosamine." | 1.28 | Differential susceptibility of a fish, tilapia Oreochromis mossambicus (Teleostei, Cichlidae) to hepatocarcinogenesis by diethylnitrosamine and methylazoxymethanol acetate. ( Ding, JL; Hee, PL; Lam, TJ, 1989) |
| "Hydroquinone (HQ) may activate oxygen via redox cycles in biological systems and may also deplete glutathione (GSH)." | 1.28 | The role of GSH depletion and toxicity in hydroquinone-induced development of enzyme-altered foci. ( Högberg, J; Lundberg, I; Rannug, A; Stenius, U; Walles, S; Warholm, M, 1989) |
| "Tfm (testicular feminization) mutant mice lack functional androgen receptors." | 1.28 | Promotion of murine hepatocarcinogenesis by testosterone is androgen receptor-dependent but not cell autonomous. ( Drinkwater, NR; Kemp, CJ; Leary, CN, 1989) |
| " In conclusion, chronic administration of thioacetamide at low doses provided strong promoting stimuli for previously initiated hepatocytes." | 1.28 | Chronic liver injury by thioacetamide and promotion of hepatic carcinogenesis. ( Gervasi, PG; Longo, V; Malvaldi, G; Marzano, M; Saviozzi, M, 1989) |
| "Phenobarbital (PB) promotes hepatic tumorigenesis when chronically administered to male B6C3F1 mice after initiation with diethylnitrosamine (DENA) at 30 days of age." | 1.28 | Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender. ( Klaunig, JE; Weghorst, CM, 1989) |
| "Diethylnitrosamine was injected to Sprague-Dawley rats after a partial hepatectomy, and enzyme histochemistry analysis was made after 35 weeks in the preneoplastic liver." | 1.27 | [Enzymatic phenotype of preneoplastic islands induced in the rat liver by diethylnitrosamine]. ( Domingo, J; Estadella, MD; Pujol, MJ, 1983) |
| " Chronic administration of dose levels of PB below 0." | 1.27 | The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration. ( Campbell, HA; Goldsworthy, T; Pitot, HC, 1984) |
| " The results show that the experimental protocols using an initiator and a promotor are not equivalent (in term of latency period and premalignant lesions) to experimental protocols using a chronic administration of one carcinogenic compound." | 1.27 | [Comparative systemic analysis of experimental models of chemical hepatic carcinogenesis in the rat]. ( de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H, 1984) |
| "Trichloroethylene was not found to induce GGT-positive foci under these conditions." | 1.27 | Trichloroethylene effects on the formation of enzyme-altered foci in rat liver. ( Couri, D; Milks, MM, 1984) |
| " This demonstrates that chronic administration of an exogenous compound is not the only way to promote cancer development." | 1.27 | [Promoting effect of portacaval anastomosis in experimental hepatic carcinogenesis]. ( de Gerlache, J; Lans, M; Pector, JC; Préat, V; Roberfroid, M; Taper, H, 1984) |
| "In diethylnitrosamine (DEN)-treated rats, which were fed a N-2-fluorenylacetamide (FAA)-containing diet and additionally treated with repeated CCl4 injections, gamma-glutamyl transpeptidase (gamma-GTP)-positive hyperplastic nodules were markedly developed in the 8th week of the experiment." | 1.27 | Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma. ( Sakata, T, 1984) |
| " Under these experimental conditions, the long term administration of glutathione appears to have no observable influence on liver cancer development in this model." | 1.27 | Failure of glutathione to prevent liver cancer development in rats initiated with diethylnitrosamine in the resistant hepatocyte model. ( Ahluwalia, MB; Farber, E; Roomi, MW; Rotstein, J; Tatematsu, M, 1983) |
| "The phenobarbital treatment became unnecessary when neoplastic nodules were present." | 1.27 | Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect. ( Barbason, H; Betz, EH; Rassenfosse, C, 1983) |
| " The dose-response relationship, transformation probabilities, and the dose versus time to 50% incidence of the early (basophilic foci) and later appearing focal and nodular hepatocellular lesions were evaluated." | 1.27 | Kinetics of diethylnitrosamine hepatocarcinogenesis in the infant mouse. ( Mihailovich, N; Vesselinovitch, SD, 1983) |
| "Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
| "When phenobarbital was present in the diet, feeding the high polyunsaturated fat diet slightly increased the number of GGT-positive foci and the incidence of tumors." | 1.27 | Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats. ( Glauert, HP; Pitot, HC, 1986) |
| " In the second experiment, the effect of chronic administration of PB and NAF given after I without S or after S without I was analyzed." | 1.27 | Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis. ( de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H, 1986) |
| "Using the rat liver foci bioassay a dose-response relationship was evaluated for the promoting activity of the ubiquitous and persistent environmental pollutants polychlorinated biphenyls (PCBs) and chloroform." | 1.27 | Dose-response of promotion by polychlorinated biphenyls and chloroform in rat liver foci bioassay. ( Deml, E; Oesterle, D, 1987) |
| " Therefore, we have begun to quantify the dose-response relationships for N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis by characterizing the major promutagenic DNA adduct, O4-ethyldeoxythymidine (O4-etdT); hepatocyte proliferation; and hepatocyte initiation in rats continually exposed to drinking-water containing NDEA." | 1.27 | Molecular dosimetry of DNA alkylation during chronic exposure to carcinogens. ( Boucheron, JA; Deal, FH; Richardson, FC; Swenberg, JA; Tyeryar, LA, 1987) |
| "Diethylnitrosamine was used as initiating agent of hepatocarcinogenesis and lipid peroxidation levels were monitored in the homogenates from normal liver, hyperplastic nodules and tumour, incubated in the presence or in the absence of ascorbate or adenosine diphosphate-iron complex." | 1.27 | Resistance to oxidative stress by hyperplastic and neoplastic rat liver tissue monitored in terms of production of unpolar and medium polar carbonyls. ( Biasi, F; Biocca, ME; Canuto, RA; Cecchini, G; Chiarpotto, E; Dianzani, MU; Esterbauer, H; Muzio, G; Poli, G, 1986) |
| " Putative preneoplastic lesions in the liver were first observed according to the substance and dosage applied as follows: DENA 1 X weekly (group II), beginning on day 258; DENA 2 X weekly (group III), beginning on day 183; and CC + DENA 2 X weekly (group V), beginning on day 231." | 1.27 | Histology and histochemistry of the liver of chickens after DENA induced hepatocarcinogenesis and ingestion of low chlorinated biphenyls. ( Brunn, H; Eigenbrodt, E; Manz, D; Reinacher, M; Schmidt, E, 1987) |
| "We have investigated levels of transcript homologous with glutathione S-transferase P (GST-P; GST 7-7) in tumours and hyperplastic lesions induced in the livers of rats by long-term gavage dosing with diethylnitrosamine (DEN) and 6-p-dimethylaminophenylazobenzothiazole (6BT)." | 1.27 | Long-term dosing studies using mutagenic carcinogens indicate a highly significant correlation between elevations in the level of rat glutathione S-transferase P messenger RNA and liver tumours of hepatocellular origin. ( Humphries, P; Kelly, M; McQuaid, S; Pearson, C; Russell, SE, 1988) |
| "Thiourea (TU) fails to enhance the incidence of foci deficient in adenosine-5'-triphosphatase (ATPase) either by initiation or by promotion in a rat liver foci bioassay." | 1.27 | Lack of initiating and promoting activity of thiourea in rat liver foci bioassay. ( Deml, E; Oesterle, D, 1988) |
| "The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment." | 1.27 | Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion. ( Klaunig, JE; Pereira, MA; Ruch, RJ; Weghorst, CM, 1988) |
| " These results indicate that, when administered by this route, NDEA is a much more potent carcinogen in the respiratory tract than is NDMA but NDMA alone seems to be carcinogenic to the liver, at a total dosage of 1." | 1.27 | A comparison of the carcinogenicity of N-nitrosodiethylamine and N-nitrosodimethylamine after intratracheal instillation into Syrian golden hamsters. ( Hirata, M; Hisanaga, A; Inamasu, T; Ishinishi, N; Tanaka, A, 1988) |
| " The analysis of dose-response data showed first order kinetics (single event) regarding the induction of intermediate basophilic foci (IBF) and hepatocellular carcinomas (HCC)." | 1.27 | Certain aspects of hepatocarcinogenesis in the infant mouse model. ( Vesselinovitch, SD, 1987) |
| " The dose levels in the individual dose-response experiments ranged from the lowest concentrations of previous experiments (NDEA, 0." | 1.27 | Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats. ( Berger, MR; Schmähl, D; Zerban, H, 1987) |
| "Diazepam was more effective than oxazepam and its effect was proportionate to dose." | 1.27 | Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver. ( Diwan, BA; Rice, JM; Ward, JM, 1986) |
| "The dose-response relationship was determined in rats for the enhancement by phenobarbital of diethylnitrosamine (DENA)-initiated neoplastic nodules and hepatocellular carcinomas." | 1.27 | Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver. ( Herren-Freund, SL; Long, RE; Pereira, MA, 1986) |
| " In subchronic studies, PB was administered in drinking water to 5-week-old male hamsters for periods of 8 or 16 weeks at dosage levels of 250, 500, or 1000 ppm." | 1.27 | Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters. ( Anderson, LM; Diwan, BA; Hagiwara, A; Rice, JM; Ward, JM, 1986) |
| " A simple two-stage model of rat hepatocarcinogenesis with a single ip dose of diethylnitrosamine (DEN) as the initiator and sodium phenobarbitone or ethanol given in the drinking-water for 12-18 months as the promoter was used to investigate dose-response relationships for initiation and promotion." | 1.27 | Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol. ( Driver, HE; McLean, AE, 1986) |
| "When hexachlorobenzene or lindane were administered in the diet to rats that previously received a 2/3 partial hepatectomy prior to the DENA." | 1.26 | Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver. ( Britt, AL; Herren, SL; Khoury, MM; Pereira, MA, 1982) |
| "Using the Solt and Farber model (Nature, 263 (1976) 701), dose-response relationships between initiating agents and the induction of hyperplastic nodules in rat liver were investigated." | 1.26 | Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis. ( Imaida, K; Ito, N; Shirai, T; Takano, T; Tatematsu, M, 1981) |
| "Diethylnitrosamine (DENA) was administered with drinking water (40 mg/liter) to male Wistar rats for 4, 6, 8, and 10 weeks." | 1.26 | Nonhistone protein changes during the diethylnitrosamine-induced carcinogenesis of rat liver. ( Baguena, J; Gabaldon, M; Martinez-Sales, V, 1981) |
| "After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50)." | 1.26 | [Comparative investigations on the organotropic carcinogenic effect of different N-nitroso compounds with rat after single and chronic treatment (author's transl)]. ( Kouros, M; Manncke, K; Schweinsberg, F, 1979) |
| "When diethylnitrosamine treatment was stopped, there was a rapid drop in polymerase beta activity." | 1.26 | Sequential changes in DNA polymerases alpha and beta during diethylnitrosamine-induced carcinogenesis. ( Ansley, CM; Craddock, VM, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 360 (26.22) | 18.7374 |
| 1990's | 413 (30.08) | 18.2507 |
| 2000's | 255 (18.57) | 29.6817 |
| 2010's | 295 (21.49) | 24.3611 |
| 2020's | 50 (3.64) | 2.80 |
| Authors | Studies |
|---|---|
| Balaraman, G | 2 |
| Sundaram, J | 2 |
| Mari, A | 2 |
| Krishnan, P | 2 |
| Salam, S | 2 |
| Subramaniam, N | 2 |
| Sirajduddin, I | 1 |
| Thiruvengadam, D | 3 |
| Mamdouh, AM | 1 |
| Khodeer, DM | 1 |
| Tantawy, MA | 1 |
| Moustafa, YM | 1 |
| Liu, C | 5 |
| Yang, Y | 5 |
| Chen, C | 2 |
| Li, L | 3 |
| Li, J | 5 |
| Wang, X | 7 |
| Chu, Q | 1 |
| Qiu, L | 1 |
| Ba, Q | 1 |
| Li, X | 5 |
| Wang, H | 7 |
| Badr, AM | 1 |
| El-Ahwany, E | 2 |
| Goda, L | 1 |
| Nagy, F | 1 |
| Helal, N | 1 |
| El Deeb, S | 1 |
| Chao, X | 1 |
| Wang, S | 3 |
| Hlobik, M | 1 |
| Ballabio, A | 1 |
| Ni, HM | 2 |
| Ding, WX | 1 |
| Vidya, R | 1 |
| Kalaivani, K | 1 |
| Amudha, P | 1 |
| Kidoguchi, S | 1 |
| Kitada, K | 1 |
| Nakajima, K | 1 |
| Nakano, D | 1 |
| Ohsaki, H | 1 |
| Kittikulsuth, W | 1 |
| Kobara, H | 1 |
| Masaki, T | 1 |
| Yokoo, T | 1 |
| Takahashi, K | 3 |
| Titze, J | 1 |
| Nishiyama, A | 1 |
| Zepeda-Bastida, A | 1 |
| Ocampo-López, J | 1 |
| Alarcón-Sánchez, BR | 2 |
| Idelfonso-García, OG | 2 |
| Rosas-Madrigal, S | 2 |
| Aparicio-Bautista, DI | 2 |
| Pérez-Carreón, JI | 3 |
| Villa-Treviño, S | 10 |
| Arellanes-Robledo, J | 3 |
| Lu, Y | 5 |
| Wang, Y | 7 |
| He, Y | 1 |
| Pan, J | 2 |
| Jin, Y | 1 |
| Zheng, L | 2 |
| Huang, Y | 1 |
| Li, Y | 7 |
| Liu, W | 3 |
| Abdel-Hamid, NM | 2 |
| Abass, SA | 1 |
| Eldomany, RA | 1 |
| Abdel-Kareem, MA | 1 |
| Zakaria, S | 1 |
| Punvittayagul, C | 4 |
| Luangsuphabool, T | 1 |
| Wongpoomchai, R | 5 |
| Priya, S | 1 |
| Kma, L | 1 |
| Akree, LS | 1 |
| Amin, ZA | 1 |
| Ahmad, HO | 1 |
| Sánchez-Meza, J | 1 |
| Campos-Valdez, M | 1 |
| Domínguez-Rosales, JA | 1 |
| Godínez-Rubí, JM | 1 |
| Rodríguez-Reyes, SC | 1 |
| Martínez-López, E | 1 |
| Zúñiga-González, GM | 1 |
| Sánchez-Orozco, LV | 1 |
| Morsy, HM | 1 |
| Ahmed, OM | 1 |
| Zoheir, KMA | 1 |
| Abdel-Moneim, A | 1 |
| Hegazy, RR | 1 |
| Mansour, DF | 1 |
| Salama, AA | 1 |
| Abdel-Rahman, RF | 1 |
| Hassan, AM | 1 |
| Kumar, P | 1 |
| Agarwal, A | 1 |
| Singh, AK | 1 |
| Gautam, AK | 1 |
| Chakraborti, S | 1 |
| Kumar, U | 1 |
| Kumar, D | 1 |
| Bhattacharya, B | 1 |
| Panda, P | 1 |
| Saha, B | 1 |
| Qidwai, T | 1 |
| Maity, B | 1 |
| Saha, S | 1 |
| Mo'men, YS | 2 |
| Hussein, RM | 2 |
| Kandeil, MA | 2 |
| Mello, T | 2 |
| Materozzi, M | 1 |
| Zanieri, F | 1 |
| Simeone, I | 1 |
| Ceni, E | 1 |
| Bereshchenko, O | 1 |
| Polvani, S | 1 |
| Tarocchi, M | 1 |
| Marroncini, G | 1 |
| Nerlov, C | 1 |
| Guasti, D | 1 |
| Bani, D | 1 |
| Pinzani, M | 2 |
| Galli, A | 2 |
| Ding, Z | 1 |
| Ericksen, RE | 1 |
| Escande-Beillard, N | 1 |
| Lee, QY | 1 |
| Loh, A | 1 |
| Denil, S | 1 |
| Steckel, M | 1 |
| Haegebarth, A | 1 |
| Wai Ho, TS | 1 |
| Chow, P | 1 |
| Toh, HC | 1 |
| Reversade, B | 1 |
| Gruenewald, S | 1 |
| Han, W | 1 |
| Feng, Q | 1 |
| Zhang, H | 4 |
| Nie, X | 1 |
| Chen, WD | 1 |
| Wang, YD | 1 |
| Chen, Q | 5 |
| You, X | 1 |
| Yang, W | 5 |
| Jiang, S | 1 |
| Lai, J | 1 |
| Bai, L | 3 |
| Wakana, H | 1 |
| Kono, H | 1 |
| Fukushima, H | 1 |
| Nakata, Y | 1 |
| Akazawa, Y | 1 |
| Maruyama, S | 1 |
| Hagio, K | 1 |
| Fujii, H | 1 |
| Ichikawa, D | 1 |
| Schulien, I | 1 |
| Hockenjos, B | 1 |
| van Marck, V | 1 |
| Ayata, CK | 1 |
| Follo, M | 1 |
| Thimme, R | 1 |
| Hasselblatt, P | 1 |
| Haberl, EM | 2 |
| Pohl, R | 2 |
| Rein-Fischboeck, L | 2 |
| Feder, S | 2 |
| Sinal, CJ | 2 |
| Bruckmann, A | 1 |
| Hoering, M | 1 |
| Krautbauer, S | 1 |
| Liebisch, G | 1 |
| Buechler, C | 2 |
| Lin, YH | 1 |
| Zhang, S | 5 |
| Zhu, M | 1 |
| Lu, T | 1 |
| Chen, K | 1 |
| Wen, Z | 2 |
| Xiao, G | 1 |
| Luo, D | 1 |
| Jia, Y | 2 |
| MacConmara, M | 1 |
| Hoshida, Y | 2 |
| Singal, AG | 1 |
| Yopp, A | 1 |
| Wang, T | 1 |
| Zhu, H | 4 |
| Sojoodi, M | 1 |
| Wei, L | 1 |
| Erstad, DJ | 1 |
| Yamada, S | 1 |
| Fujii, T | 1 |
| Hirschfield, H | 1 |
| Kim, RS | 1 |
| Lauwers, GY | 1 |
| Lanuti, M | 1 |
| Tanabe, KK | 1 |
| Fuchs, BC | 1 |
| Badr El-Din, NK | 1 |
| Ali, DA | 1 |
| Othman, R | 1 |
| French, SW | 1 |
| Ghoneum, M | 1 |
| Chen, L | 4 |
| Yi, X | 1 |
| Guo, P | 1 |
| Guo, H | 2 |
| Chen, Z | 2 |
| Hou, C | 1 |
| Qi, L | 1 |
| Li, C | 3 |
| Liu, P | 1 |
| Liu, Y | 1 |
| Xu, Y | 4 |
| Zhang, N | 1 |
| Unsal, V | 1 |
| Kurutaş, EB | 1 |
| Song, L | 1 |
| Zhang, JG | 1 |
| Feng, X | 2 |
| Hou, J | 1 |
| Zhang, HL | 5 |
| Liu, SF | 2 |
| Perkons, NR | 2 |
| Johnson, O | 2 |
| Pilla, G | 1 |
| Profka, E | 2 |
| Mercadante, M | 1 |
| Ackerman, D | 1 |
| Gade, TPF | 1 |
| Ma, M | 1 |
| Zhou, Y | 3 |
| Sun, R | 2 |
| Shi, J | 1 |
| Tan, Y | 1 |
| Yang, H | 2 |
| Zhang, M | 2 |
| Shen, R | 1 |
| Xu, L | 1 |
| Wang, Z | 2 |
| Fei, J | 1 |
| Song, J | 1 |
| Ding, W | 1 |
| Liu, B | 2 |
| Liu, D | 1 |
| Xia, Z | 1 |
| Zhang, L | 3 |
| Cui, L | 2 |
| Luo, Y | 3 |
| Jia, X | 1 |
| Feng, L | 2 |
| Zhang, C | 4 |
| Chen, Y | 8 |
| Xu, C | 1 |
| Gong, G | 1 |
| Veeraraghavan, VP | 1 |
| Bolla, SR | 1 |
| Memon, A | 1 |
| Pyao, Y | 1 |
| Jung, Y | 1 |
| Lee, JI | 1 |
| Lee, WK | 1 |
| Hanna, D | 1 |
| Sugamori, KS | 1 |
| Bott, D | 1 |
| Grant, DM | 1 |
| Khan, MGM | 1 |
| Ghosh, A | 4 |
| Variya, B | 1 |
| Santharam, MA | 1 |
| Ihsan, AU | 1 |
| Ramanathan, S | 1 |
| Ilangumaran, S | 1 |
| Park, BJ | 1 |
| Morley, C | 1 |
| Appel, S | 1 |
| Nadolski, GJ | 1 |
| Hunt, SJ | 1 |
| Gade, TP | 1 |
| Takasu, S | 1 |
| Ishii, Y | 10 |
| Kijima, A | 1 |
| Ogawa, K | 15 |
| Nakane, S | 1 |
| Umemura, T | 3 |
| Liu, J | 2 |
| Li, P | 2 |
| Wang, L | 5 |
| Li, M | 2 |
| Ge, Z | 1 |
| Noordam, L | 1 |
| Lieshout, R | 1 |
| Verstegen, MMA | 1 |
| Ma, B | 1 |
| Su, J | 1 |
| Yang, Q | 2 |
| Zhang, R | 1 |
| Zhou, G | 2 |
| Carrascosa, LC | 1 |
| Sprengers, D | 1 |
| IJzermans, JNM | 1 |
| Smits, R | 1 |
| Kwekkeboom, J | 1 |
| van der Laan, LJW | 1 |
| Peppelenbosch, MP | 1 |
| Pan, Q | 2 |
| Cao, W | 1 |
| Dolicka, D | 1 |
| Sobolewski, C | 1 |
| Gjorgjieva, M | 1 |
| Correia de Sousa, M | 1 |
| Berthou, F | 1 |
| De Vito, C | 1 |
| Colin, DJ | 1 |
| Bejuy, O | 1 |
| Fournier, M | 1 |
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| Blackshear, PJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biomarker Analyses in Hepatocellular Carcinoma Patients Treated With Therasphere®[NCT03203837] | 4 participants (Actual) | Observational | 2017-07-05 | Terminated (stopped due to Funding Discontinued due to low accrual rate) | |||
| Treatment of Advanced Hepatocellular Carcinoma With Depot Somatostatin Analogues: a Pilot Prospective Study Based on Somatostatin Receptors Tumors Expression[NCT00495846] | Phase 2/Phase 3 | 25 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for diethylnitrosamine and Experimental Hepatoma
| Article | Year |
|---|---|
A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Biological Assay; Biomarkers, Tumor; Carcino | 2003 |
Receptor-mediated toxicity and implications for risk assessment.
Topics: Animals; Cell Division; Cocarcinogenesis; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; D | 1994 |
[Recent progress in molecular biology of chemically-induced hepatic carcinogenesis].
Topics: Animals; Diethylnitrosamine; Genes, myc; Genes, p53; Genes, ras; Humans; Insulin-Like Growth Factor | 1993 |
Genetic analysis of multistage hepatocarcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Disease | 1996 |
[Genetic control of hepatocarcinogenesis in mice].
Topics: Animals; Carcinogens; Diethylnitrosamine; Gene Expression Regulation; Genetic Predisposition to Dise | 2001 |
Diethylnitrosamine-induced hepatocarcinogenesis in rats: a theoretical study.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Li | 1991 |
Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice.
Topics: Adenoma; Animals; Biotransformation; Cocarcinogenesis; Diethylnitrosamine; Disease Susceptibility; F | 1990 |
The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver.
Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros | 1985 |
Trends in pathobiochemical studies of tumour development and progression.
Topics: Animals; Cell Transformation, Neoplastic; Chromatin; Diethylnitrosamine; DNA; Homeostasis; Humans; L | 1986 |
Single-hit versus multi-hit concept of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylni | 1985 |
1 trial available for diethylnitrosamine and Experimental Hepatoma
| Article | Year |
|---|---|
Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Carbon Tetrachloride; Carcinoma, Hepa | 2013 |
1362 other studies available for diethylnitrosamine and Experimental Hepatoma
| Article | Year |
|---|---|
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Farnesol; Inflammation; Liver; | 2021 |
In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma.
Topics: alpha-Fetoproteins; Amygdalin; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogen | 2021 |
Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice.
Topics: Animals; B7-H1 Antigen; Carbon Tetrachloride; Chemokine CCL2; Diethylnitrosamine; Drug Resistance, N | 2021 |
MicroRNA-26a systemic administration attenuates tumor formation in hepatocellular carcinoma mouse model.
Topics: Alkylating Agents; alpha-Fetoproteins; Animals; Apoptosis; Biomarkers; Carcinoma, Hepatocellular; Ca | 2021 |
Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Topics: Alcohol Drinking; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinogenes | 2022 |
Therapeutic Potential of Cucumis melo (L.) Fruit Extract and Its Silver Nanopartciles Against DEN-Induced Hepatocellular Cancer in Rats.
Topics: Animals; Carcinoma, Hepatocellular; Cucumis melo; Diethylnitrosamine; Fruit; Liver Neoplasms, Experi | 2022 |
Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats.
Topics: Aldosterone; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms, Experimental; | 2022 |
Aqueous extracts from
Topics: Animals; beta Catenin; Diethylnitrosamine; Ki-67 Antigen; Larva; Liver Neoplasms, Experimental; Male | 2021 |
Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chromatography, Liquid; Cytoc | 2022 |
Dual regulating of mitochondrial fusion and Timp-3 by leflunomide and diallyl disulfide combination suppresses diethylnitrosamine-induced hepatocellular tumorigenesis in rats.
Topics: Alkylating Agents; Allyl Compounds; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Dieth | 2022 |
Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogenesis; Diethylnitrosamine; Female; Glutathio | 2022 |
Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma.
Topics: alpha-Fetoproteins; Animals; Body Weight; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; | 2022 |
In silico and in vivo hepatoprotective activity of the synthesized 5-benzylidene-2-thiohydantoin against diethylnitrosamine-induced liver injury in a rat model.
Topics: Animals; Chemical and Drug Induced Liver Injury, Chronic; Diethylnitrosamine; Humans; Interleukin-6; | 2023 |
Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; L | 2023 |
The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Diethylnitrosamine; Eugenol; Liv | 2023 |
Regulation of PKB/Akt-pathway in the chemopreventive effect of lactoferrin against diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspartate Aminotransferases; Cell Proliferat | 2019 |
Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; | 2019 |
A novel chemoprotective effect of tiopronin against diethylnitrosamine-induced hepatocellular carcinoma in rats: Role of ASK1/P38 MAPK-P53 signalling cascade.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Li | 2020 |
Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carcinogenesis; Carcinoma, Hepatocellu | 2020 |
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
Topics: Aldehyde Dehydrogenase; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; delt | 2020 |
miR-149* Suppresses Liver Cancer Progression by Down-Regulating Tumor Necrosis Factor Receptor 1-Associated Death Domain Protein Expression.
Topics: Alkylating Agents; Animals; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Diethylnitrosamine | 2020 |
Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Inflammation; Liver; | 2020 |
Effects of Medium-chain Triglycerides Administration in Chemically-induced Carcinogenesis in Mice.
Topics: 3-Hydroxybutyric Acid; Adipocytes; Adipokines; Adiponectin; Adipose Tissue; Aldehydes; Animal Feed; | 2019 |
Extracellular ATP and Purinergic P2Y
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; C | 2020 |
Overexpression of Hepatocyte Chemerin-156 Lowers Tumor Burden in a Murine Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Chemokines; Cholesterol; Diethylnitrosamine; Diglycerides; Disea | 2019 |
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced | 2020 |
Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; Catechin; Cellular Senescen | 2020 |
Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinogenesis; Cell Cycle | 2020 |
The role of bone marrow-derived cells in the origin of liver cancer revealed by single-cell sequencing.
Topics: Animals; Biomarkers, Tumor; Bone Marrow Cells; Bone Marrow Transplantation; Carcinoma, Hepatocellula | 2020 |
Citral inhibits N-nitrosodiethylamine-induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic-metabolizing enzymes.
Topics: Acyclic Monoterpenes; alpha-Fetoproteins; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; | 2020 |
Investigation of the Effects of Octreotide Agent on Oxidative Stress, 8-Hydroxy Deoxyguanosine in Experimental Hepatic Carcinogenesis Rat Model.
Topics: 2-Acetylaminofluorene; 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Hormonal; Carcin | 2020 |
Establishment of rat liver cancer cell lines with different metastatic potential.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Disease Models, Animal; Ka | 2020 |
Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Hepatocellular; CRISPR-Cas Systems; D | 2020 |
STAT3 and AKT signaling pathways mediate oncogenic role of NRSF in hepatocellular carcinoma.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethylnitros | 2020 |
Anticancer effect of caudatin in diethylnitrosamine‑induced hepatocarcinogenesis in rats.
Topics: Activating Transcription Factor 4; Activating Transcription Factor 6; Animals; Antineoplastic Agents | 2020 |
Vicenin-2 Treatment Attenuated the Diethylnitrosamine-Induced Liver Carcinoma and Oxidative Stress through Increased Apoptotic Protein Expression in Experimental Rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apigenin; Apo | 2020 |
A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2020 |
The impact of sex on hepatotoxic, inflammatory and proliferative responses in mouse models of liver carcinogenesis.
Topics: Aging; Aminobiphenyl Compounds; Animals; Carcinogenesis; Cell Proliferation; Chemical and Drug Induc | 2020 |
Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Diethyln | 2020 |
Three-Dimensional Augmented Reality Visualization Informs Locoregional Therapy in a Translational Model of Hepatocellular Carcinoma.
Topics: Acrylic Resins; Animals; Augmented Reality; Carcinoma, Hepatocellular; Diethylnitrosamine; Embolizat | 2020 |
Furan Induced Characteristic Glutathione
Topics: Animals; Diethylnitrosamine; Female; Furans; Gene Expression; Glutathione Transferase; Kinetics; Liv | 2020 |
Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance.
Topics: Animals; Antineoplastic Agents; Cancer-Associated Fibroblasts; Carcinoma, Hepatocellular; Coculture | 2021 |
Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Diethylnitr | 2021 |
Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats.
Topics: Animals; Annona; Antineoplastic Agents, Phytogenic; Antioxidants; Carbon Tetrachloride; Carcinoma, H | 2020 |
Inhibitory and ameliorative effect of heliomycin derived from actinomycete on induced hepatocellular carcinoma in rats.
Topics: Actinobacteria; Alanine Transaminase; alpha-Fetoproteins; Animals; Anticarcinogenic Agents; Aspartat | 2021 |
Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks.
Topics: Androgens; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; | 2021 |
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model.
Topics: Activity Cycles; Animals; Behavior, Animal; Biomarkers; Carcinoma, Hepatocellular; Chronotherapy; Ci | 2021 |
Optimized protocol for an inducible rat model of liver tumor with chronic hepatocellular injury, inflammation, fibrosis, and cirrhosis.
Topics: Animals; Carcinogenesis; Diethylnitrosamine; Humans; Inflammation; Liver Cirrhosis, Experimental; Li | 2021 |
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocel | 2021 |
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Animals; Arginine; Carcinogenesis; Carcinoma, Hep | 2021 |
N-nitrosodiethylamine induces inflammation of liver in mice.
Topics: Animals; Body Weight; Diethylnitrosamine; Inflammation; Liver; Liver Neoplasms, Experimental; Mice; | 2021 |
Chemopreventive Effect of
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Clusiaceae | 2021 |
The Therapeutic Effect of Myrrh (Commiphora molmol) and Doxorubicin on Diethylnitrosamine Induced Hepatocarcinogenesis in Male Albino Rats.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Carcinoma, Hepatocellular; Commiphora; Diethylnitrosamine; | 2021 |
Ameliorative potential of manganese nanoparticles with low-level ionizing radiation against experimentally induced hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gamma Rays; Liver; Liver Neoplasms, Experime | 2021 |
The chemo-prophylactic efficacy of an ethanol Moringa oleifera leaf extract against hepatocellular carcinoma in rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers | 2017 |
CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression.
Topics: Animals; Aurora Kinase B; Biological Transport; Carcinogens; Carcinoma, Hepatocellular; Cell Nucleus | 2018 |
In vivo antitumour potential of camel's milk against hepatocellular carcinoma in rats and its improvement of cisplatin renal side effects.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Camelus; Carcinoma, Hepatocellular; Cisplatin; Dieth | 2017 |
Antitumor Activities of the Novel Isosteviol Derivative 10C Against Liver Cancer.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Proliferation; | 2017 |
Deriving and testing of dysplastic murine hepatocytes: A new platform in liver cancer research.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Cell Transformation, | 2017 |
Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Heme Oxygenase-1; Inflammat | 2017 |
Time-caloric restriction inhibits the neoplastic transformation of cirrhotic liver in rats treated with diethylnitrosamine.
Topics: Animals; Caloric Restriction; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, Neopla | 2017 |
Chronic Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis via Immune Disturbances.
Topics: Alcohol Drinking; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Pr | 2017 |
Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis.
Topics: Animals; Cell Survival; Cell Transformation, Neoplastic; Diethylnitrosamine; Hepatocytes; Liver Neop | 2017 |
Nrf2 Mutagenic Activation Drives Hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Apoptosis; Cell Proliferation; Diethylnitrosamine; Female; Humans; Liver | 2017 |
An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease M | 2018 |
Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation, Ne | 2017 |
Umbelliferon-α-d-glucopyranosyl-(2
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Proliferation; Cytok | 2017 |
Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice.
Topics: Animals; Caloric Restriction; Carcinogenesis; Carcinogens; Chemical and Drug Induced Liver Injury; D | 2017 |
Reduction of liver tumerogenic effect of N-nitrosodiethylamine by treatment with ɣ-oryzanol in Balb/C mice.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; Dose-Response | 2017 |
Contradictory effects of mitochondria- and non-mitochondria-targeted antioxidants on hepatocarcinogenesis by altering DNA repair in mice.
Topics: Acetylcysteine; Animals; Antioxidants; Ataxia Telangiectasia Mutated Proteins; Chromans; Diethylnitr | 2018 |
An integrative analysis of chemically-induced cirrhosis-associated hepatocarcinogenesis: Histological, biochemical and molecular features.
Topics: Alanine Transaminase; Animals; Annexin A2; Aspartate Aminotransferases; Carcinogenesis; Collagen; Co | 2017 |
Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB pathway in mice.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Deoxyadenosines; Diethylnitrosamine; Do | 2017 |
Identification of (Z)-2,3-Diphenylacrylonitrileas Anti-Cancer Molecule in Persian Gulf Sea Cucumber Holothuria parva.
Topics: 2-Acetylaminofluorene; Acrylonitrile; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chr | 2017 |
Anticancer potential of ZnO nanoparticle-ferulic acid conjugate on Huh-7 and HepG2 cells and diethyl nitrosamine induced hepatocellular cancer on Wistar albino rat.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Prolif | 2018 |
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Gen | 2017 |
Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma.
Topics: Animals; Arginase; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Diethylnitrosamine; Fema | 2018 |
The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cell Proliferation; | 2018 |
The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepato | 2018 |
Effect of diosmin on apoptotic signaling molecules in N-nitrosodiethylamine-induced hepatocellular carcinoma in experimental rats.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Diosmin; Liver Neoplasms, Experim | 2018 |
Ellagic Acid Holds Promise Against Hepatocellular Carcinoma\
in an Experimental Model: Mechanisms of Action
Topics: Alkylating Agents; alpha-Fetoproteins; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cells, | 2018 |
Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer.
Topics: Animals; CCAAT-Enhancer-Binding Proteins; Diethylnitrosamine; End Stage Liver Disease; Gene Expressi | 2018 |
Rheum palmatum root extract inhibits hepatocellular carcinoma in rats treated with diethylnitrosamine.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Aspartate Aminotransferases | 2018 |
Therapeutic role of calcium and vitamin K3 in chemically induced hepatocarcinogenesis - new tools for cancer treatment.
Topics: Alkylating Agents; Animals; Biomarkers; Calcium; Carcinoma, Hepatocellular; Caspase 3; Diethylnitros | 2019 |
Impact of Mesenchymal Stem Cells and Vitamin D on Transforming Growth Factor Beta Signaling Pathway in Hepatocellular Carcinoma in Rats
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cells, Cultured; Diethylnitrosamine; Female; | 2018 |
Chemerin in a Mouse Model of Non-alcoholic Steatohepatitis and Hepatocarcinogenesis.
Topics: Adiponectin; Animals; Body Composition; Chemokines; Choline Deficiency; Diethylnitrosamine; Gene Exp | 2018 |
Augmentation of diethylnitrosamine-induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenesis; Carcinogens; Cell Proliferation; Colon; Diethylnitro | 2019 |
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
Topics: Animals; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholangiocarcinoma; Chole | 2018 |
Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosam | 2018 |
Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Circadian Clocks; Diethylnitrosamine; Endoplas | 2018 |
Inhibitory effects of mushroom extracts on progression of carcinogenesis in mice.
Topics: Agaricus; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transfo | 2018 |
Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antineop | 2018 |
Mutational landscape of a chemically-induced mouse model of liver cancer.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; DNA Copy Number Variations; Exome; Genes, ras; | 2018 |
Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diet, | 2018 |
FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice.
Topics: Animals; Carcinoma, Hepatocellular; Caspase 1; Diethylnitrosamine; Hepatocytes; Humans; Inflammasome | 2019 |
Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell | 2019 |
Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Susceptibility | 2018 |
Effect of sitagliptin, a DPP-4 inhibitor, against DENA-induced liver cancer in rats mediated via NF-κB activation and inflammatory cytokines.
Topics: Animals; Antineoplastic Agents; Biomarkers; Blood Glucose; Cytokines; Diethylnitrosamine; Dipeptidyl | 2018 |
Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma.
Topics: Animals; Cell Proliferation; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Female; Gen | 2018 |
Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles.
Topics: Animals; Antioxidants; Apocynaceae; Biomarkers, Tumor; Diethylnitrosamine; Down-Regulation; Female; | 2018 |
Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Drug Synergism; Female; Injections | 2018 |
DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss.
Topics: Animals; Carcinogenesis; DEAD-box RNA Helicases; Diethylnitrosamine; DNA Damage; Female; Liver Neopl | 2019 |
Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b.
Topics: Animals; Antigens, Differentiation; Basic Helix-Loop-Helix Transcription Factors; Cocarcinogenesis; | 2019 |
STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytokines; Diethylni | 2019 |
Protective role of fucoxanthin in diethylnitrosamine-induced hepatocarcinogenesis in experimental adult rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Diethylnitrosamine; Liver; Liver Neoplasms, Experiment | 2019 |
Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes.
Topics: Animals; beta-Carotene 15,15'-Monooxygenase; Carcinoma, Hepatocellular; Carotenoids; Diet, High-Fat; | 2018 |
Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats.
Topics: Angiotensin Receptor Antagonists; Animals; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cell Tr | 2018 |
The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways.
Topics: Adult; Aged; Aged, 80 and over; Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Di | 2018 |
Gamma linolenic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced hepatocellular carcinoma.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins | 2018 |
WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Chromosom | 2019 |
Antithrombin Insufficiency Promotes Susceptibility to Liver Tumorigenesis.
Topics: Animals; Antithrombin III; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Fema | 2019 |
Red and White Wine Lees Show Inhibitory Effects on Liver Carcinogenesis.
Topics: Alu Elements; Animals; Anticarcinogenic Agents; Body Weight; Catechols; Diethylnitrosamine; DNA Meth | 2019 |
Involvement of PI3K/Akt pathway in the protective effect of hesperidin against a chemically induced liver cancer in rats.
Topics: Animals; Diethylnitrosamine; Hesperidin; Liver Neoplasms, Experimental; Male; Phosphatidylinositol 3 | 2019 |
Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; | 2019 |
Diethylnitrosamine enhances hepatic tumorigenic pathways in mice fed with high fat diet (Hfd).
Topics: Alkylating Agents; Animals; Carcinogenesis; Diet, High-Fat; Diethylnitrosamine; Liver; Liver Neoplas | 2019 |
Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (
Topics: Animals; Antioxidants; Biomarkers; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytotoxins; Diethyln | 2019 |
Metabonomics of d-glucaro-1,4-lactone in preventing diethylnitrosamine-induced liver cancer in rats.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Glucaric Acid; Liver Neoplasms, Experimental; Metabo | 2018 |
Antihepatocarcinogenic activity of whey protein concentrate and lactoferrin in diethylnitrosamine-treated male albino mice.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Cattle; Diethylnitrosamine; Dose-Response Relationsh | 2019 |
Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides.
Topics: Animals; Diethylnitrosamine; DNA Damage; Glycolysis; Liver; Liver Neoplasms, Experimental; Male; Mic | 2019 |
Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2019 |
Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Drug Syn | 2019 |
Overproduction of thrombopoietin by BRAFV600E-mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis.
Topics: Animals; Biopsy; Blood Platelets; Bone Marrow; Capillaries; Carcinogenesis; Carcinogens; Cell Prolif | 2019 |
An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Contro | 2019 |
Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cocarcinogenesis; Cytochrome P-450 CYP1A1 | 2013 |
Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen.
Topics: Acetaminophen; Animals; beta Catenin; Carcinogens; Cell Proliferation; Cytochrome P-450 CYP2E1; Diet | 2013 |
Garlic oil attenuated nitrosodiethylamine-induced hepatocarcinogenesis by modulating the metabolic activation and detoxification enzymes.
Topics: Allyl Compounds; Animals; Biotransformation; Carcinogens, Environmental; Cell Transformation, Neopla | 2013 |
Anticancer effect of ursolic acid stearoyl glucoside in chemically induced hepatocellular carcinoma.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Antineoplastic Agents, Phyt | 2013 |
Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Biomarkers, Tumor; Body Weight; Cell Proli | 2013 |
Protective effects of Scutellaria barbata against rat liver tumorigenesis.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-L-Fucosidase; Animals; Aspartate Aminotransferases | 2013 |
Cyclin E facilitates dysplastic hepatocytes to bypass G1/S checkpoint in hepatocarcinogenesis.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neoplastic; | 2013 |
Evaluating the effect of lycopene from Lycopersicum esculentum on apoptosis during NDEA induced hepatocarcinogenesis.
Topics: Animals; Apoptosis; Base Sequence; Carcinogens; Carotenoids; Comet Assay; Diethylnitrosamine; DNA Pr | 2013 |
[Increase of general toxic effects and decrease of hepatocarcinogenic effects of diethylnitrosamine administered to mice in conjunction with isopropanol].
Topics: 2-Propanol; Alkylating Agents; Animals; Carcinogens; Cytochrome P-450 CYP2E1; Diethylnitrosamine; DN | 2012 |
In vivo modulation of iNOS pathway in hepatocellular carcinoma by Nigella sativa.
Topics: Alkylating Agents; alpha-Fetoproteins; Animals; Antineoplastic Agents; Blotting, Western; Cytokines; | 2013 |
Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Cell Cycle Proteins; C | 2013 |
Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model.
Topics: 2-Acetylaminofluorene; Animals; Cell Proliferation; Cyclooxygenase 2; Diethylnitrosamine; Diosmin; D | 2013 |
Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.
Topics: 5-Methylcytosine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosine; | 2013 |
p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release.
Topics: Animals; Cell Line; Diethylnitrosamine; Gene Knockout Techniques; Genes, p53; Hepatitis, Chronic; HM | 2013 |
Pharmacokinetic variations of tetramethylpyrazine phosphate after oral administration in hepatic precancerous mice and its hepatoprotective effects.
Topics: Administration, Oral; Animals; Area Under Curve; Diethylnitrosamine; Liver; Liver Neoplasms, Experim | 2014 |
Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells.
Topics: Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chemok | 2013 |
Inhibitory effect of α-lipoic acid on thioacetamide-induced tumor promotion through suppression of inflammatory cell responses in a two-stage hepatocarcinogenesis model in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Cocarcinogene | 2013 |
Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma.
Topics: Animals; Benzoquinones; Cell Cycle Proteins; Cell Proliferation; Diethylnitrosamine; G1 Phase Cell C | 2013 |
Panax ginseng exerts antiproliferative effects on rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Cell Proliferation; Cyclin D1; Cyclin G1; Diethylnitrosamine; Dose | 2013 |
Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase | 2013 |
Lycopene modulates initiation of N-nitrosodiethylamine induced hepatocarcinogenesis: studies on chromosomal abnormalities, membrane fluidity and antioxidant defense system.
Topics: Animals; Carotenoids; Catalase; Chromosome Aberrations; Diethylnitrosamine; Female; Glutathione Pero | 2013 |
Branched-chain amino acids ameliorate fibrosis and suppress tumor growth in a rat model of hepatocellular carcinoma with liver cirrhosis.
Topics: Administration, Oral; Amino Acids, Branched-Chain; Animals; Anticarcinogenic Agents; Carcinogenesis; | 2013 |
Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-β1-Smad4-PAI-1 axis.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neoplastic; | 2014 |
Chemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions.
Topics: Animals; Cell Growth Processes; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Lipids; Liver; | 2014 |
Nanocapsulated quercetin downregulates rat hepatic MMP-13 and controls diethylnitrosamine-induced carcinoma.
Topics: Animals; Diethylnitrosamine; Down-Regulation; Liver; Liver Neoplasms, Experimental; Male; Matrix Met | 2014 |
Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Proliferation; Cocarcinogenesis; Diethylnitrosamin | 2014 |
Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carcinogenesis; Ca | 2014 |
Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.
Topics: Animals; Caprylates; Cocarcinogenesis; Diethylnitrosamine; Dioxins; Liver Neoplasms, Experimental; M | 2014 |
Cytokeratin 7/19 expression in N-diethylnitrosamine-induced mouse hepatocellular lesions: implications for histogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regu | 2014 |
Cleistocalyx nervosum extract ameliorates chemical-induced oxidative stress in early stages of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Diethylnitrosamine; Immunoenzyme Techniqu | 2014 |
Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through activation of the Wnt/β-catenin signaling pathway.
Topics: Alcohol Drinking; Alkylating Agents; Animals; Blotting, Western; Carcinogenesis; Cell Proliferation; | 2014 |
Carvacrol modulates instability of xenobiotic metabolizing enzymes and downregulates the expressions of PCNA, MMP-2, and MMP-9 during diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Proliferation; Cymenes; Diethylnitrosamine; | 2014 |
Androgen receptor enhances cell adhesion and decreases cell migration via modulating β1-integrin-AKT signaling in hepatocellular carcinoma cells.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Dieth | 2014 |
Suppression of sulfoconjugation reduces the protective effect of ortho-aminoazotoluene on hepatocarcinogenesis induced by diethylnitrosamine in mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Diethylnitrosamine; Female; Liver; Liver Neoplasms | 2014 |
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv | 2014 |
Superoxide deficiency attenuates promotion of hepatocarcinogenesis by cytotoxicity in NADPH oxidase knockout mice.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Ethanol; Female; Liver; Liver Neoplasms, Experimental | 2015 |
DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
Topics: 2-Acetylaminofluorene; Animals; Cyclin-Dependent Kinase Inhibitor p16; Diethylnitrosamine; DNA (Cyto | 2014 |
Curative effect of Amorphophallus campanulatus (Roxb.) Blume. tuber on N-nitrosodiethylamine- induced hepatocellular carcinoma in rats.
Topics: Amorphophallus; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Dieth | 2014 |
Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis.
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Cattle; CCAAT-Binding Factor; | 2015 |
Evaluation of diethylnitrosamine- or hepatitis B virus X gene-induced hepatocellular carcinoma with 18F-FDG PET/CT: a preclinical study.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Fluorodeoxyglucose F18; Glucose Tran | 2015 |
High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diet, High-Fat; Diet | 2014 |
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Basigin; Carcinogens; Carcinoma, H | 2015 |
Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine.
Topics: Adipokines; Adiposity; Animals; Carcinogens; Diet, Ketogenic; Diet, Western; Dietary Carbohydrates; | 2015 |
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Damage; Gene Expression Regulation, Neop | 2014 |
Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model.
Topics: Alkylating Agents; Animals; beta Catenin; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellul | 2015 |
The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine | 2014 |
Curcumin ameliorate DENA-induced HCC via modulating TGF-β, AKT, and caspase-3 expression in experimental rat model.
Topics: Alanine Transaminase; Animals; Apoptosis; Caspase 3; Curcumin; Diethylnitrosamine; Disease Models, A | 2015 |
Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.
Topics: Animals; BRCA1 Protein; Carcinogens; Cell Cycle; Diethylnitrosamine; DNA Damage; Enzymes; Exonucleas | 2015 |
Involvement of constitutive androstane receptor in liver hypertrophy and liver tumor development induced by triazole fungicides.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Constitutive Andro | 2015 |
Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumo | 2015 |
Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model.
Topics: Animals; Carcinogenesis; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, | 2015 |
Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice.
Topics: Animals; Carcinogens, Environmental; Diethylnitrosamine; Disease Models, Animal; Guidelines as Topic | 2015 |
Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.
Topics: Animals; Carbon Tetrachloride; Cell Line, Tumor; Diethylnitrosamine; Gene Expression Profiling; Gene | 2016 |
NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Calgranulin A; Calgranulin B; Carcinoma, Hepatocellular; Chemokine CXCL1 | 2015 |
Significance of Rumex vesicarius as anticancer remedy against hepatocellular carcinoma: a proposal-based on experimental animal studies.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; alpha-L-Fucosidase; Animals; Antineo | 2015 |
Insights into glycan biosynthesis in chemically-induced hepatocellular carcinoma in rats: A glycomic analysis.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Computational Biology; Diethylnitrosamine; Gl | 2015 |
β-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling.
Topics: Alkylating Agents; Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Blotting, W | 2015 |
Chemoprevention of Diethylnitrosamine-Initiated and Phenobarbital-Promoted Hepatocarcinogenesis in Rats by Sulfated Polysaccharides and Aqueous Extract of Ulva lactuca.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethyln | 2015 |
Protective Effects of Total Glucosides of Paeony on N-nitrosodiethylamine-induced Hepatocellular Carcinoma in Rats via Down-regulation of Regulatory B Cells.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antineoplastic Agents, Phytogenic; Aspartate Am | 2015 |
Chemopreventive effects of pequi oil (Caryocar brasiliense Camb.) on preneoplastic lesions in a mouse model of hepatocarcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ericales; Liver Neoplasms, Experim | 2016 |
Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodioxoles; Carcinoma, Hepatocellular; Cell Cycle Chec | 2015 |
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.
Topics: alpha-Fetoproteins; Animals; Bile Ducts; Biomarkers, Tumor; Carbon Tetrachloride; Carcinogens; Cell | 2015 |
Inhibition of Diethylnitrosamine-Induced Hepatocarcinogenesis in Mice by a High Dietary Protein Intake.
Topics: Animals; Caseins; Cell Proliferation; Collagen; Dietary Proteins; Diethylnitrosamine; Hepatocytes; I | 2015 |
Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells.
Topics: Animals; Carcinogens; Cell Line; Cell Movement; Clofibrate; Diethylnitrosamine; Epithelial Cells; Ge | 2016 |
Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Proliferation; Cell Shape; Cell Transformatio | 2015 |
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Escherichia | 2015 |
Lycopene Enriched Tomato Extract Inhibits Hypoxia, Angiogenesis, and Metastatic Markers in early Stage N-Nitrosodiethylamine Induced Hepatocellular Carcinoma.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carotenoids; Cell Hypoxia; Dietary Supplements; | 2015 |
Mice with Hepatic Loss of the Desmosomal Protein γ-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis.
Topics: Animals; beta Catenin; Bile Ducts; Cell Transformation, Neoplastic; Cholestasis; Desmosomes; Diethyl | 2015 |
Testosterone regulation of cyclin E kinase: A key factor in determining gender differences in hepatocarcinogenesis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Castration; Cell Proli | 2016 |
DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Culture | 2016 |
The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.
Topics: Adenoma; Animals; CD8 Antigens; Cyclooxygenase 2; Diethylnitrosamine; Disease Progression; Forkhead | 2016 |
Induction of autophagy promotes the growth of early preneoplastic rat liver nodules.
Topics: Alkylating Agents; Animals; Autophagy; Carcinogenesis; Diethylnitrosamine; Disease Progression; Gene | 2016 |
Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Blotting, Western; Carcinogenesis; Carcinoma, Hep | 2016 |
Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Carcinoma, Hepatocellular; | 2015 |
Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Biomarkers; Camellia sinensis; Cell Transformation, | 2016 |
Acteoside-mediates chemoprevention of experimental liver carcinogenesis through STAT-3 regulated oxidative stress and apoptosis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; Cell Li | 2016 |
Umbelliferone and esculetin protect against N-nitrosodiethylamine-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diethylnitrosam | 2016 |
Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease.
Topics: Alanine Transaminase; alpha-Fetoproteins; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cel | 2016 |
Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling.
Topics: Adult; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neopl | 2016 |
Therapeutic role of a synthesized calcium phosphate nanocomposite material on hepatocarcinogenesis in rats.
Topics: Animals; Calcium Phosphates; Diethylnitrosamine; DNA Fragmentation; Enzymes; Interferon-gamma; Inter | 2016 |
Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs.
Topics: Adenoma; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2016 |
TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2016 |
Hepatic preneoplasia induction in male Wistar rats: histological studies up to five months post treatment.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hepatocytes; Liver; Liver Neoplasms | 2016 |
Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Diethylnitrosamine; DNA Damage; Glutathione Transferase; | 2016 |
Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Basidiomycota; Carcinogenesis; Cytoprotection; Diethylnitrosamine; E | 2017 |
Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biological Products; Carcinoma, Hepatoce | 2016 |
Dietary zinc deficiency predisposes mice to the development of preneoplastic lesions in chemically-induced hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Animals, Newborn; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Ce | 2016 |
G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis.
Topics: Animals; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Diethylnitrosamine | 2016 |
Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Diethylnitrosamine; Hep G2 Cells; | 2017 |
Protective effects of dieckol on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzofurans; Biomarkers; Carcinoma, Hepatocellular; | 2016 |
The antitumor activity of a lactosaminated albumin conjugate of doxorubicin in a chemically induced hepatocellular carcinoma rat model compared to sorafenib.
Topics: Animals; Antibiotics, Antineoplastic; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosami | 2017 |
A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cocarcinogenesis; Constitutive | 2016 |
Stimulation of Diethylnitrosamine Metabolism Reduces Its General Toxic and Hepatocarcinogenic Effects.
Topics: Animals; Animals, Suckling; Body Weight; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytochrome P-450 E | 2016 |
Detection and differentiation of early hepatocellular carcinoma from cirrhosis using CT perfusion in a rat liver model.
Topics: Animals; Area Under Curve; Blood Flow Velocity; Capillary Permeability; Carcinoma, Hepatocellular; C | 2016 |
Fruiting Bodies of Antrodia cinnamomea and Its Active Triterpenoid, Antcin K, Ameliorates N-Nitrosodiethylamine-Induced Hepatic Inflammation, Fibrosis and Carcinogenesis in Rats.
Topics: Alkylating Agents; Animals; Antrodia; Apoptosis; Autophagy; Carcinogenesis; Carcinoma, Hepatocellula | 2017 |
The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents, Immunological; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proli | 2017 |
Hepatoprotective effect of engineered silver nanoparticles coated bioactive compounds against diethylnitrosamine induced hepatocarcinogenesis in experimental mice.
Topics: Animals; Carcinogenesis; Carcinogens; Crystallography, X-Ray; Diethylnitrosamine; Liver; Liver Neopl | 2017 |
A long term, non-tumorigenic rat hepatocyte cell line and its malignant counterpart, as tools to study hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Cell Line; Cell Line, Transformed; Cell Transformation, | 2017 |
A novel approach towards design, synthesis and evaluation of some Schiff base analogues of 2-aminopyridine and 2-aminobezothiazole against hepatocellular carcinoma.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Antioxidants; Benzothiazoles; Biphenyl Compounds; Ca | 2017 |
Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats.
Topics: Adenosine; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Disease Models, Animal; Liver Cirrh | 2017 |
Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Progression; Hepatitis; | 2017 |
Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Topics: Acetyl-CoA Carboxylase; Alkylating Agents; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatoc | 2017 |
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesi
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Chitin; Chitosan; Colonic Neoplasms; Dieth | 2008 |
Forssman antigen content of guinea pig hepatomas induced by diethylnitrosamine: a quantitative approach to the search for tumor-specific antibodies.
Topics: Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Carcinogens; Diethylnitrosamine; Forssman Antigen | 1966 |
Threshold dose of piperonyl butoxide that induces reactive oxygen species-mediated hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Gene Expres | 2009 |
Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis.
Topics: Animals; Apoptosis; Carcinogens; Cell Proliferation; Diethylnitrosamine; Genetic Therapy; Interferon | 2008 |
Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis.
Topics: Animals; Cell Count; Cell Movement; Diethylnitrosamine; Down-Regulation; Immunohistochemistry; Liver | 2009 |
The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine.
Topics: Animals; Asparagus Plant; Carcinogens; Diethylnitrosamine; Glutathione; Immunohistochemistry; Liver; | 2008 |
Vesicular flavonoid in combating diethylnitrosamine induced hepatocarcinoma in rat model.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catalase; Diethylnit | 2008 |
[Dendritic cell vaccine modified by murine mAFP gene enhances immunoprotective effect on liver carcinogenesis and tumor development in mice].
Topics: Adenoviridae; alpha-Fetoproteins; Animals; B7-1 Antigen; Cancer Vaccines; Carbon Tetrachloride; Cell | 2008 |
Antioxidant effects of flavonoids used as food additives (purple corn color, enzymatically modified isoquercitrin, and isoquercitrin) on liver carcinogenesis in a rat medium-term bioassay.
Topics: Animals; Anthocyanins; Anticarcinogenic Agents; Antioxidants; Diethylnitrosamine; Flavonoids; Food A | 2008 |
Effect of DENA induced hepatocarcinogenesis on neuroendocrine levels in male rats.
Topics: Animals; Brain; Carcinoma, Hepatocellular; Diethylnitrosamine; Dopamine; gamma-Glutamyltransferase; | 2008 |
Effect of carotenoids on in vitro proliferation and differentiation of oval cells during neoplastic and non-neoplastic liver injuries in rats.
Topics: Animals; Anticarcinogenic Agents; beta Carotene; Cell Differentiation; Cell Proliferation; Cell Tran | 2008 |
Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Diter | 2009 |
[Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis].
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Rats; Rats, Sprague-Dawley; Signal | 2008 |
Diallyl sulfide protects against N-nitrosodiethylamine-induced liver tumorigenesis: role of aldose reductase.
Topics: Aldehyde Reductase; Allyl Compounds; Animals; Anticarcinogenic Agents; Antioxidants; Cell Transforma | 2008 |
Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diethylnitrosamine; Disease Progression; Glutathione S- | 2009 |
Regulation of iron metabolism-related genes in diethylnitrosamine-induced mouse liver tumors.
Topics: Adenoma, Liver Cell; Animals; Antimicrobial Cationic Peptides; Cation Transport Proteins; Ceruloplas | 2009 |
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Proliferation; Diethylnitrosamine; Di | 2009 |
Hepatocyte-specific activation of NF-kappaB does not aggravate chemical hepatocarcinogenesis in transgenic mice.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Electro | 2009 |
Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype.
Topics: Animals; Apoptosis; Cell Differentiation; Choline Deficiency; Diethylnitrosamine; Glutathione Transf | 2009 |
Suppressive effect of Siraitia grosvenorii extract on dicyclanil-promoted hepatocellular proliferative lesions in male mice.
Topics: Alkylating Agents; Animals; Antioxidants; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Cell | 2009 |
Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease M | 2009 |
Anti-angiogenic therapy on hepatocellular carcinoma development and progression.
Topics: alpha-Fetoproteins; Angiogenesis Inhibitors; Animals; Diethylnitrosamine; Disease Progression; Inter | 2010 |
Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Gene Expression Regulati | 2009 |
Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine.
Topics: Acetaminophen; Alkaloids; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chlorides | 2009 |
Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark.
Topics: Acacia; Animals; Biomarkers, Tumor; Body Weight; Carbon Tetrachloride; Carcinogens; Diethylnitrosami | 2009 |
Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Celecoxib; Cyclooxygenase Inhibitors; Diethylnitrosamine; Li | 2009 |
Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences.
Topics: Alkylating Agents; Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neopl | 2009 |
Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Carci | 2009 |
Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats.
Topics: Animals; Blotting, Western; Carcinogens; Carotenoids; Cell Transformation, Neoplastic; Chromatograph | 2010 |
[Inhibitory effects of Scutellaria barbate extracts on diethylnitrosamine-induced hepatocarcinoma in rats].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antineoplastic Agents, Phytogenic; Aspartate Am | 2009 |
Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.
Topics: Adipose Tissue; Animals; Base Sequence; Cells, Cultured; Diethylnitrosamine; DNA Primers; Female; Fl | 2009 |
Mechanistic study on hepatocarcinogenesis of piperonyl butoxide in mice.
Topics: Activating Transcription Factor 3; Animals; Body Weight; Carcinogenicity Tests; Cyclin D; Diethylnit | 2009 |
Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Body Weight; Cell Proliferation; Cyclophospha | 2010 |
Insulin-independent promotion of chemically induced hepatocellular tumor development in genetically diabetic mice.
Topics: Animals; Diabetes Complications; Diethylnitrosamine; Germ-Line Mutation; Insulin; Liver Neoplasms, E | 2010 |
[Differentially expressed proteins in the precancerous stage of rat hepatocarcinogenesis induced by diethylnitrosamine].
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Diethylnitrosamine; gamma-Glutamyltransferase | 2009 |
Diethylnitrosamine (DEN) induces irreversible hepatocellular carcinogenesis through overexpression of G1/S-phase regulatory proteins in rat.
Topics: Actins; Alkylating Agents; Animals; Blotting, Western; Body Weight; Cell Cycle; Cell Cycle Proteins; | 2009 |
Modulation of energy metabolic enzyme expression in N-nitrosodiethylamine-mediated hepatocarcinogenesis by Chinese herbs, Huqi San.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drugs, Chinese Herbal | 2008 |
Efficacy of lanreotide in preventing the occurrence of chemically induced hepatocellular carcinoma in rats.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Cell Proliferation; Diethylnitrosamine; Fibros | 2010 |
[Inhibitory effect of thyroxine on late stages of hepatocarcinogenesis induced in suckling mice by diethylnitrosamine].
Topics: Alkylating Agents; Animals; Animals, Suckling; Diethylnitrosamine; Kidney; Liver; Liver Neoplasms, E | 2009 |
Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice.
Topics: Alanine Transaminase; Amino Acids, Branched-Chain; Animals; Diabetes Complications; Dietary Suppleme | 2010 |
Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Diethylnitro | 2010 |
Morin fosters apoptosis in experimental hepatocellular carcinogenesis model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Binding Sites; | 2010 |
Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse.
Topics: Alkylating Agents; Animals; Apoptosis; Colony-Forming Units Assay; Diethylnitrosamine; Hepatocytes; | 2010 |
[Diethylnitrosamine-induced carcinogenesis in PARP-1(-/-) and PARP-1(+/+) mice].
Topics: Animals; Carcinogens; Cholangiocarcinoma; Diethylnitrosamine; DNA Repair; Female; Hemangiosarcoma; I | 2009 |
Cytokeratin 8/18 is a useful immunohistochemical marker for hepatocellular proliferative lesions in mice.
Topics: Adenoma; Animals; Biomarkers; Carcinoma; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatectomy; | 2010 |
Bacoside A downregulates matrix metalloproteinases 2 and 9 in DEN-induced hepatocellular carcinoma.
Topics: Animals; Diethylnitrosamine; Down-Regulation; Liver Neoplasms, Experimental; Male; Matrix Metallopro | 2010 |
Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats.
Topics: Adenosine Triphosphatases; Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, | 2009 |
Effect of selenium-enriched malt on VEGF and several relevant angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats.
Topics: Animals; Cytokines; Diethylnitrosamine; Edible Grain; Liver Neoplasms, Experimental; Neovascularizat | 2010 |
Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats.
Topics: Animals; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Liver Neoplas | 2009 |
Tumor promotion by copper-overloading and its enhancement by excess iron accumulation involving oxidative stress responses in the early stage of a rat two-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Copper; Diethylnitrosamine; Glutathione Transferase; Im | 2010 |
Nuclear translocation of telomerase reverse transcriptase: a critical process in chemical induced hepatocellular carcinogenesis.
Topics: Active Transport, Cell Nucleus; Animals; Cell Nucleus; Diethylnitrosamine; Liver Neoplasms, Experime | 2010 |
Supplementation of selenium reduces chemical hepatocarcinogenesis in male Sprague-Dawley rats.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Humans; Liver; Liver Neoplasms, Experimental; Male; | 2010 |
Application of magnetic resonance imaging in transgenic and chemical mouse models of hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; G | 2010 |
Preventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on DEN-induced hepatocarcinogenesis in rats.
Topics: Animals; Apoptosis; Benzenesulfonates; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferat | 2010 |
Nuclear factor-kappa B as a promising target for selenium chemoprevention in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Cyclin D1; | 2010 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose | 2010 |
Immunohistochemical analyses at the late stage of tumor promotion by oxfendazole in a rat hepatocarcinogenesis model.
Topics: Adenoma, Liver Cell; Animals; Anthelmintics; Apoptosis; Benzimidazoles; Carcinogens; Cell Cycle Prot | 2011 |
Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Blotting, Western; Carcinoma, Hepatocellular; Diethylni | 2011 |
Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro.
Topics: Adenoviridae; Alkylating Agents; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Lin | 2010 |
Resistance to cisplatin-induced apoptosis via PI3K-dependent survivin expression in a rat hepatoma cell line.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultu | 2010 |
Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Primers; DNA, Complem | 2010 |
[O-aminoazotoluene inhibits DENA-induced hepatocarcinogenesis when used together in mice].
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Drug Administration Schedule; Liv | 2010 |
Carcinogenic risk assessment: are there dose thresholds for carcinogens?
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Damage; Glutathione Transferase; Intestinal Neoplasms; | 2010 |
Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Fucose; Fucosyltransferases; Liver; Liv | 2010 |
Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms, Experimental; Mic | 2010 |
Gas chromatography/time-of-flight mass spectrometry-based metabonomics of hepatocarcinoma in rats with lung metastasis: elucidation of the metabolic characteristics of hepatocarcinoma at formation and metastasis.
Topics: Animals; Biomarkers, Tumor; Carcinoma; Computational Biology; Diethylnitrosamine; Gas Chromatography | 2010 |
Preparation of 177Lu-labeled oxine in lipiodol as a possible agent for therapy of hepatocellular carcinoma: a preliminary animal study.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Evaluation, Preclinical; Ethiodized Oil | 2010 |
Dissection of DEN-induced platelet proteome changes reveals the progressively dys-regulated pathways indicative of hepatocarcinogenesis.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Blood Platelets; Blotting, Western; Carcinoma, Hepatocellul | 2010 |
Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Glutathione S-Transferase pi; Immunohistochemistry; | 2011 |
Methylated chrysin, a dimethoxy flavone, partially suppresses the development of liver preneoplastic lesions induced by N-nitrosodiethylamine in rats.
Topics: Animals; Base Sequence; Carcinogens; Cell Cycle Proteins; Diethylnitrosamine; DNA Primers; DNA Repai | 2011 |
AFP-specific immunotherapy impairs growth of autochthonous hepatocellular carcinoma in mice.
Topics: alpha-Fetoproteins; Animals; Cancer Vaccines; CD8-Positive T-Lymphocytes; Diethylnitrosamine; Female | 2011 |
Production of liver preneoplasia and gallbladder agenesis in turkey fetuses administered diethylnitrosamine.
Topics: Animals; Biological Assay; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response | 2011 |
Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver.
Topics: Adult Stem Cells; Animals; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Diethylnitrosam | 2011 |
Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cytokines; Diabetes Complications; Diabetes Melli | 2011 |
Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes.
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Gene Expression Regulation, Neoplastic | 2010 |
Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arrestins; beta-Arrestin | 2011 |
Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats.
Topics: Animals; beta-Naphthoflavone; Body Weight; Cytochrome P-450 CYP1A1; Diethylnitrosamine; Enzyme Induc | 2011 |
Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; | 2011 |
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Topics: Animals; Anthocyanins; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Prolifer | 2011 |
Overexpression of histone variant H2A.1 and cellular transformation are related in N-nitrosodiethylamine-induced sequential hepatocarcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Densitometry; Diethylnitrosamine; Electrophoresis, Gel, Tw | 2011 |
Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis.
Topics: Acyltransferases; Animals; Carbon Tetrachloride; Cell Transformation, Neoplastic; Cells, Cultured; D | 2011 |
Estrogen suppresses metastasis in rat hepatocellular carcinoma through decreasing interleukin-6 and hepatocyte growth factor expression.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Estrogens; Ethinyl Estradiol; Female; Hepato | 2012 |
Quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in rats.
Topics: Analysis of Variance; Animals; Biological Assay; Diethylnitrosamine; Glutathione Transferase; Hepate | 2011 |
Alpha-fetoprotein-thymidine kinase-luciferase knockin mice: a novel model for dual modality longitudinal imaging of tumorigenesis in liver.
Topics: alpha-Fetoproteins; Animals; Diethylnitrosamine; Disease Models, Animal; Disease Progression; Female | 2011 |
Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3.
Topics: Animals; Cell Cycle Checkpoints; Cell Proliferation; Cell Transformation, Neoplastic; Constitutive A | 2011 |
Mutations and aberrant transcriptions of Stk11 (Lkb1) gene in rat liver tumors.
Topics: Amino Acids; AMP-Activated Protein Kinase Kinases; Animals; Carcinogens; Cell Transformation, Neopla | 2011 |
Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.
Topics: Alkylating Agents; Animals; Antioxidants; Blotting, Western; Carcinoma, Hepatocellular; Diethylnitro | 2011 |
Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Weight; Carcinogens; Deoxyguanosine; Diethylnitrosamine; | 2011 |
Effect of Aegle marmelos on DEN initiated and 2-AAF promoted hepatocarcinogenesis: a chemopreventive study.
Topics: 2-Acetylaminofluorene; Aegle; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinogens; | 2011 |
Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats.
Topics: Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; ATP-Binding Cassette Transporters; | 2011 |
Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Cytokines; Diethylnitrosamine; Female; Gene Expression Regulation; | 2012 |
Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats.
Topics: Alcoholism; Animals; Apoptosis; Carcinogens; Cell Proliferation; Diethylnitrosamine; Ethanol; Hepato | 2011 |
The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis.
Topics: Animals; Diethylnitrosamine; Estradiol; Estrogen Receptor alpha; Female; Gene Expression; Growth Hor | 2011 |
Identification of biomarkers of chemically induced hepatocarcinogenesis in rasH2 mice by toxicogenomic analysis.
Topics: 1-Naphthylisothiocyanate; 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinogens; Cluster An | 2011 |
Saffron: a potential candidate for a novel anticancer drug against hepatocellular carcinoma.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Crocus; Cyclooxygenase 2; Diethylnitrosamine; | 2011 |
Dose-related induction of hepatic preneoplastic lesions by diethylnitrosamine in C57BL/6 mice.
Topics: Animals; Carcinogenicity Tests; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationsh | 2011 |
RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Chromosome Aberrations; Comparat | 2011 |
Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Apoptosis; bcl-Associated Death Protein; Cocarc | 2011 |
c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; C | 2011 |
Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cymenes; | 2012 |
Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Cycle; Cell Proliferation; Cyclin D; Diethylnitr | 2012 |
Transforming growth factor-β-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis.
Topics: Animals; Blotting, Western; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Ge | 2012 |
Anticarcinogenic activity of nanoencapsulated quercetin in combating diethylnitrosamine-induced hepatocarcinoma in rats.
Topics: Alkylating Agents; Animals; Antioxidants; Blotting, Western; Capsules; Carcinoma, Hepatocellular; Cy | 2012 |
Mechanistic study on liver tumor promoting effects of flutamide in rats.
Topics: Androgen Antagonists; Animals; Body Weight; Diethylnitrosamine; Flutamide; Immunohistochemistry; Lip | 2012 |
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) promotes mouse hepatocarcinogenesis by activating transforming growth factor-β and Wnt/β-catenin signaling pathways.
Topics: Animals; beta Catenin; Blotting, Western; Body Weight; Carcinoma, Hepatocellular; Cell Adhesion; Cel | 2012 |
Diethylnitrosamine-induced hepatocarcinogenesis is suppressed in lecithin:retinol acyltransferase-deficient mice primarily through retinoid actions immediately after carcinogen administration.
Topics: Acyltransferases; Alanine Transaminase; Animals; Apoptosis; Carcinogens; Cell Proliferation; Cell Tr | 2012 |
Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Alkylating Agents; Animals; Antioxidants; Carcinogens; | 2011 |
Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced hepatocellular carcinoma.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Dr | 2012 |
STAT3 activation in monocytes accelerates liver cancer progression.
Topics: Aminosalicylic Acids; Analysis of Variance; Animals; Apoptosis; Benzenesulfonates; Carcinogens; Carc | 2011 |
Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: involvement of CCAAT/enhancer binding protein β and cyclooxygenase-2.
Topics: Animals; Bupleurum; CCAAT-Enhancer-Binding Protein-beta; Chemoprevention; Cyclooxygenase 2; Diethyln | 2012 |
Nanocapsulated curcumin: oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Curcumin; Diethylnitrosamine; Glutathi | 2012 |
Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response.
Topics: Alkylating Agents; Animals; Anthocyanins; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic | 2013 |
Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Genetic Predisposition to Disease; Glycerol-3-Phosp | 2012 |
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer.
Topics: Adaptive Immunity; Animals; B-Lymphocytes; Biomarkers; Carcinogens; Carcinoma, Hepatocellular; Chemo | 2012 |
Quantitative analysis of the growth kinetics of chemically induced mouse liver tumors by magnetic resonance imaging.
Topics: Animal Use Alternatives; Animals; Cocarcinogenesis; Diethylnitrosamine; Early Detection of Cancer; I | 2012 |
The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats.
Topics: Animals; Carcinoma, Hepatocellular; Cynara scolymus; Diethylnitrosamine; Dose-Response Relationship, | 2011 |
Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Caffeic Acids; Carcinogenicity Tests; Cytochr | 2012 |
Anticancer effects of Huaier are associated with down-regulation of P53.
Topics: Alanine Transaminase; alpha-Fetoproteins; Animals; Antineoplastic Agents, Phytogenic; Diethylnitrosa | 2011 |
Autologous bone marrow cell infusions suppress tumor initiation in hepatocarcinogenic mice with liver cirrhosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Carcinoma, | 2012 |
Protective effects of garlic oil on hepatocarcinoma induced by N-nitrosodiethylamine in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Allyl Compounds; Animals; Anticarcinogenic Agents; Antioxidants; Apopto | 2012 |
Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice.
Topics: Alkylating Agents; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular | 2012 |
Myrtenal ameliorates diethylnitrosamine-induced hepatocarcinogenesis through the activation of tumor suppressor protein p53 and regulation of lysosomal and mitochondrial enzymes.
Topics: Animals; Antineoplastic Agents; Bicyclic Monoterpenes; Carbohydrate Metabolism; Carcinogenesis; Citr | 2013 |
DEN+2-AAF-induced multistep hepatotumorigenesis in Wistar rats: supportive evidence and insights.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Diethylnitrosamine; Disease Models, Animal; Lipid Pe | 2013 |
Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Constitutive Androstane Receptor; Deoxyguanosine; | 2012 |
A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Biphenyl Compounds; Body Weight; Cell Line; Di | 2012 |
The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Proliferation; Cell Shape; Cel | 2012 |
SJSZ glycoprotein (38kDa) prevents thymus atrophy and enhances expression of IL-2 and IL-12 in diethylnitrosamine-induced hepatocarcinogenesis.
Topics: Animals; Atrophy; Cytokines; Diethylnitrosamine; Glycoproteins; Immunity, Cellular; Immunologic Fact | 2012 |
Age-dependent carcinogenic susceptibility in rat liver is related to potential of gap junctional intercellular communication.
Topics: Animals; Carcinogens; Cell Communication; Connexins; Diethylnitrosamine; Disease Susceptibility; Gap | 2012 |
Selenium supplementation reduced oxidative stress in diethylnitrosamine-induced hepatocellular carcinoma in rats.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Dietary Supplements; Diethylnitrosamine; Liver Neo | 2011 |
Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Aldehyde Dehydrogenase 1 Family; Animals; Carcino | 2012 |
Threshold dose of liver tumor promoting effect of β-naphthoflavone in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Chemokine CCL2; Cyclooxygenase 2; Cytoc | 2012 |
The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma.
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Kupffer Cells; Liver Neoplasms, Experi | 2012 |
Myrtenal attenuates diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Bicyclic Monoterpenes; | 2012 |
Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Anti-Bacterial Agents; Bifidobacterium; Carcinoma, Hepatocellular; Cytok | 2012 |
β-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice.
Topics: Animals; beta Catenin; Carcinogens; Diethylnitrosamine; Hepatocytes; Immunohistochemistry; Ligands; | 2012 |
Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl4-induced hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Body Weight; Carbon Tetrachloride; Ca | 2012 |
Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; E | 2013 |
Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Anthocyanins; Antioxidants; Blotting, Western; Carcinoma, Hepatocellular | 2012 |
Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development.
Topics: AC133 Antigen; Animals; Antigens, CD; Antigens, Differentiation; Antigens, Neoplasm; Biomarkers, Tum | 2012 |
Effects of pinocembrin on the initiation and promotion stages of rat hepatocarcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Flavanones; Glutathione S-Transfera | 2012 |
Increased expression of chondroitin sulphate proteoglycans in rat hepatocellular carcinoma tissues.
Topics: Animals; Carcinoma, Hepatocellular; Chondroitin Sulfate Proteoglycans; Diethylnitrosamine; Liver Neo | 2012 |
SJSZ glycoprotein (38 kDa) modulates macrophage type 1/2-related factors at hepatocarcinogenic stage in N-nitrosodiethylamine-treated Balb/c.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Glycoprot | 2013 |
Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor.
Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Blood Proteins; Calcium Sign | 2013 |
Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and β-naphthoflavone.
Topics: Animals; beta-Naphthoflavone; Carbon Tetrachloride; Carcinogens; Cyclooxygenase 2; Cytochrome P-450 | 2012 |
Increased expression of epithelial cell adhesion molecule (EpCAM) in rat hepatic tumors induced by diethylnitrosamine.
Topics: Alkylating Agents; Animals; Antigens, Neoplasm; Apoptosis; Cell Adhesion Molecules; Cell Proliferati | 2012 |
Antihepatotoxic activity of Euphorbia neriifolia extract against N-nitrosodiethylamine-induced hepatocarcinogenesis in mice.
Topics: Animals; Antioxidants; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Euphorbia; L | 2012 |
Effect of carotenoid lutein on N-nitrosodiethylamine-induced hepatocellular carcinoma and its mechanism of action.
Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspartate Aminotransferases; Cytochrome P-45 | 2013 |
Inductive effect of phytoglycoprotein (38 kDa) on G₀/G₁ arrest and apoptosis in diethylnitrosamine-treated ICR mice.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Caspase 3 | 2013 |
Elevated expression of complement C3 protein in chemically induced hepatotumorogenesis in Wistar rats: a correlative proteomics and histopathological study.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Biomarkers; Blotting, Western; Complement C3; D | 2013 |
The connection of β-catenin and phenobarbital in murine hepatocarcinogenesis: a critical discussion of Awuah et al., PLoS ONE 7(6):e39771, 2012.
Topics: Animals; beta Catenin; Carcinogens; Diethylnitrosamine; Hepatocytes; Liver Neoplasms, Experimental; | 2013 |
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
Topics: Animals; Animals, Newborn; Carbon Tetrachloride; Cell Transformation, Neoplastic; Diethylnitrosamine | 2013 |
Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Indole | 2013 |
Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Progression; Gen | 2013 |
Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Carcinogens; Cell Line, Tumor; Deoxyguanosine; Diet | 2013 |
Resveratrol down-regulates Myosin light chain kinase, induces apoptosis and inhibits diethylnitrosamine-induced liver tumorigenesis in rats.
Topics: Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Diethylnitrosamine; Down-R | 2013 |
[Influence of bear bile on rat hepatocarcinoma induced by diethylnitrosamine].
Topics: Actins; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Bile; Bil | 2012 |
The effect of caffeic acid phenethyl ester analogues in a modified resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Acetanilides; Animals; Anticarcinogenic Agents; Antioxidants; Caffeic Acids; | 2013 |
Lack of modification of rat hepatocarcinogenesis by fernane-type triterpenoids, isolated from a Euphorbia genus.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Diethylnitrosa | 2002 |
Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.
Topics: Acid Anhydride Hydrolases; Animals; Base Sequence; Blotting, Western; Carcinogens; Diethylnitrosamin | 2002 |
Anomalous elevation of glutathione S-transferase P-form (GST-P) in the elementary process of epigenetic initiation of chemical hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Cell Nucleus; Cell Size; Cells, Cultured; Diethylnitrosamine; Electrolyt | 2002 |
Promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin and 17beta-estradiol in male Sprague-Dawley rats.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Cytochrome P-450 CYP1A1; Diethylnitrosam | 2002 |
Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis.
Topics: Animals; Carcinogens; Chromosome Mapping; Crosses, Genetic; Diethylnitrosamine; Female; Genetic Link | 2002 |
Overexpression of cyclin D1 is associated with the decondensation of chromatin during den-induced sequential hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chromatin; Cyclin D1; Diethylni | 2002 |
Demonstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; beta-Galactosidase; Carcinoma, Hepatocell | 2002 |
In ovo carcinogenicity assay (IOCA): evaluation of mannitol, caprolactam and nitrosoproline.
Topics: Animals; Caprolactam; Carcinogenicity Tests; Carcinogens; Cells, Cultured; Diethylnitrosamine; Dose- | 2002 |
Dynamic changes of matrix metalloproteinases in rat liver during the development of diethylnitrosamine-induced hepatocarcinoma.
Topics: Animals; Carcinogens; Diethylnitrosamine; Immunohistochemistry; Liver; Liver Neoplasms, Experimental | 2002 |
Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.
Topics: Animals; beta Catenin; Cytoskeletal Proteins; Diethylnitrosamine; Glutamate-Ammonia Ligase; Liver Ne | 2002 |
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione | 2002 |
[Influence of spleen on cell cycle and expression of proliferating cell nuclear antigen of the liver during diethylnitrosamine-induced rat hepatocarcinogenesis].
Topics: Animals; Cell Cycle; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Proliferating C | 2002 |
Administration of diethylnitrosamine in the immediate postnatal period coupled with exposure to a choline deficient diet accelerates hepatocarcinogenesis in the rat.
Topics: Alanine Transaminase; Animals; Animals, Newborn; Blood Glucose; Choline Deficiency; Cocarcinogenesis | 2002 |
Loss of Igf2 imprinting in monoclonal mouse hepatic tumor cells is not associated with abnormal methylation patterns for the H19, Igf2, and Kvlqt1 differentially methylated regions.
Topics: Animals; Base Sequence; Carcinogens; Diethylnitrosamine; DNA Methylation; DNA, Neoplasm; Genomic Imp | 2003 |
Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Astragalus Plant; Astragalus propinquus; Blotting, Northern; Blottin | 2003 |
Changes in hepatic enzyme activities in transgenic mice carrying human prototype c-Ha-ras gene treated with diethylnitrosamine.
Topics: Animals; Aspartate Aminotransferases; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Disease Mo | 2002 |
Relationship between the imaging features and pathologic alteration in hepatoma of rats.
Topics: Alkylating Agents; Angiography, Digital Subtraction; Animals; Carcinoma, Hepatocellular; Cell Transp | 2003 |
[Studies on liver cancer induced by non-necrotizing dose of diethylnitrosamine in rats].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Glutathione Transferase; Liver Neoplasms, Exper | 2001 |
Sodium selenite, dietary micronutrient, prevents the lymphocyte DNA damage induced by N-nitrosodiethylamine and phenobarbital promoted experimental hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Dietary Supplements; Diethylnitrosamine; | 2003 |
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Beta vulgaris; Betacyanins; Body | 2003 |
[Dynamic study of hepatocellular pathological change and uptake rate of 125I-insulin during experimental hepatocarcinogenesis].
Topics: Animals; Diethylnitrosamine; Insulin; Iodine Radioisotopes; Liver; Liver Neoplasms, Experimental; Ra | 2000 |
[Changes in some parameters of nitric oxide synthesis in the early periods of development of hepatocarcinogenesis].
Topics: Animals; Arginine; Catalase; Diethylnitrosamine; Lipid Peroxidation; Liver; Liver Neoplasms, Experim | 2002 |
Inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Curcuma; Diet; Diethylnitrosamine; Dose-Response Rela | 2003 |
[Studies on extracellular matrices in rat hepatocarcinogenesis induced by diethylnitrosamine].
Topics: Animals; Collagen Type IV; Diethylnitrosamine; Extracellular Matrix; Fibronectins; Laminin; Liver Ne | 2002 |
Tumor promotion by metanil yellow and malachite green during rat hepatocarcinogenesis is associated with dysregulated expression of cell cycle regulatory proteins.
Topics: Animals; Azo Compounds; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Transformation, Neoplas | 2003 |
Chemopreventive effect of orange oil on the development of hepatic preneoplastic lesions induced by N-nitrosodiethylamine in rats: an ultrastructural study.
Topics: Animals; Carcinogens; Diethylnitrosamine; Gap Junctions; Liver; Liver Neoplasms, Experimental; Male; | 2002 |
Effect of A-L tonic capsule on DNA content in rat experimental hepatocarcinogenesis.
Topics: Animals; Astragalus propinquus; Capsules; Carcinogenicity Tests; Diethylnitrosamine; DNA, Neoplasm; | 2002 |
Menhaden oil inhibited gamma-glutamyltransferase-positive altered hepatic foci in female Sprague-Dawley rats.
Topics: Animals; Corn Oil; Dietary Fats; Diethylnitrosamine; Fatty Acids, Omega-3; Female; Fish Oils; gamma- | 2002 |
Enhancing effects of mustard oil on preneoplastic hepatic foci development in Wistar rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; gamma-Glutamyltransferase; Glutathione Tra | 2003 |
Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci.
Topics: Agaricus; Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers, Tumor; Brazil; Bromodeoxyuridine; | 2003 |
[Effect of tea polyphenols and tea pigments on inducing the activity of phase II detoxicating enzymes and on the chemoprevention of liver precancerous lesions].
Topics: Animals; Antineoplastic Agents, Phytogenic; Diethylnitrosamine; Flavonoids; Glutathione Transferase; | 2000 |
Preliminary investigation on regulating effects of different TCM treatments on transcription of the correlated genes of liver cancer in rats.
Topics: Animals; Diethylnitrosamine; Drugs, Chinese Herbal; Genes, ras; Liver Neoplasms, Experimental; Male; | 2003 |
Suppressive effect of herbal compound 861 on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Blotting, Western; Body Weight; Diethylnitrosami | 2003 |
Influence of sodium selenite on glycoprotein contents in normal and N-nitrosodiethylamine initiated and phenobarbital promoted rat liver tumors.
Topics: Animals; Biomarkers; Blood Proteins; Carcinoma, Hepatocellular; Diethylnitrosamine; Glycoproteins; H | 2003 |
Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkylating Agents; Animals; Apoptosis; Cell Division; Cytochrome P-450 | 2003 |
Effects of dietary taurine supplementation on hepatic morphological changes of rats in diethylnitrosamine-induced hepatocarcinogenesis.
Topics: Animals; Carcinogens; Diet; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Rats; Ra | 2003 |
Selective accumulation of ALA-induced PpIX and photodynamic effect in chemically induced hepatocellular carcinoma.
Topics: Alkylating Agents; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylni | 2003 |
ras oncogene mutations in diethylnitrosamine-induced hepatic tumors in medaka (Oryzias latipes), a teleost fish.
Topics: Amino Acid Sequence; Animals; Base Sequence; Diethylnitrosamine; DNA Mutational Analysis; Genes, ras | 2003 |
Chemopreventive effect of garlic powder diet in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Dietary Supplements; Diethylnitrosamine; Garlic; Glutathione Perox | 2003 |
Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat.
Topics: Agaricus; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diet; Diethylnitrosamine; Eati | 2003 |
Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; DNA-Binding Prot | 2003 |
[On the morphology of diethylnitrosamine induced liver changes and tumors in rats].
Topics: Amines; Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Neoplasms; Rats | 1961 |
[Tumor-associated hetero-organic antigens as markers of deranged cell differentiation and malignancy].
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Carcinogens; Cell Differentiation; Cell Transformati | 2003 |
[N-nitrosodiethylamine-induced changes in the liver of syrian hamster with superinvasive opistorchiasis].
Topics: Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Fibrosis; Liver; Liver Neoplasms, Experimental | 2003 |
Study on mechanism of multistep hepatotumorigenesis in rat: development of hepatotumorigenesis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carcinogens; Cell Transforma | 2001 |
Reduced hepatocyte proliferation is the basis of retarded liver tumor progression and liver regeneration in mice lacking N-acetylglucosaminyltransferase III.
Topics: Acetylglucosamine; Animals; Apoptosis; Carbohydrate Sequence; Carcinogens; Cell Division; Diethylnit | 2003 |
Effect of dietary selenite on N-nitrosodiethylamine-induced and phenobarbital promoted multistage hepatocarcinogenesis in rat: reflection in some minerals.
Topics: Animals; Antineoplastic Agents; Carcinogens; Diet; Diethylnitrosamine; Iron; Liver; Liver Neoplasms, | 2003 |
Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma.
Topics: Acetylcysteine; Animals; Aspirin; Blotting, Western; Carcinogens; Diethylnitrosamine; E-Selectin; En | 2004 |
Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Diethyl | 2004 |
An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation.
Topics: Animals; Anticarcinogenic Agents; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Dru | 2004 |
Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Antineoplastic Agents; Ardisia; Carcinogens; Ca | 2004 |
Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine.
Topics: Agaricus; Animals; Anticarcinogenic Agents; Carcinogens; Comet Assay; Diethylnitrosamine; DNA Damage | 2003 |
Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Administration, Oral; Animals; Biphenyl Compounds; Body | 2004 |
Preventive effect of Ganfujian granule on experimental hepatocarcinoma in rats.
Topics: Alkylating Agents; Animals; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Division; Diethylnitr | 2004 |
Alterations of the M6p/Igf2 receptor gene in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Choline Deficiency; Codon; Colchi | 2004 |
Heterozygous p53-deficient (+/-) mice develop fewer p53-negative preneoplastic focal liver lesions in response to treatment with diethylnitrosamine than do wild-type (+/+) mice.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cycl | 2004 |
1alpha, 25-dihydroxyvitamin D3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Carcinogens; Comet Assay; Diet; Diethylni | 2004 |
Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Analysis of Variance; Animals; Biomarkers, Tumor; Cacao | 2004 |
Combined supplementation of vanadium and beta-carotene suppresses placental glutathione S-transferase-positive foci and enhances antioxidant functions during the inhibition of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: Animals; Antioxidants; beta Carotene; Body Weight; Cytosol; Diethylnitrosamine; Drug Synergism; Fema | 2004 |
Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine.
Topics: Animals; Antioxidants; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Dru | 2004 |
Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Body Weight; Carcinogens; Citrus; Coumari | 2004 |
Induction of preneoplastic altered hepatic foci following dietary sulphur supplementation.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Biomarkers, Tumor; | 2004 |
Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Diethylnitrosamine; | 2004 |
Induction of preneoplastic rat liver lesions with an attenuated p53 response by low doses of diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Glutathione S-Transferase pi; | 2004 |
A modified rat model for hepatocellular carcinoma.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Laparot | 2004 |
Comparison of different initiation protocols in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Animals, Newborn; Carcinogens; Diethylnitrosamine | 2005 |
B-raf and Ha-ras mutations in chemically induced mouse liver tumors.
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA, Neoplasm; Genes, ras; Humans; Liv | 2005 |
Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Antioxidants; Diethylnitrosamine; Ethylnitrosourea; gamma-Glutamyltransf | 2005 |
Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.
Topics: Animals; Carcinogens; Clone Cells; Diethylnitrosamine; Female; Gene Frequency; Liver; Liver Neoplasm | 2005 |
Chemopreventive effect of indole-3-carbinol on induction of preneoplastic altered hepatic foci.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Diethylnitrosamine; g | 2004 |
Chemoprevention of N-nitrosodiethylamine induced phenobarbitol promoted liver tumors in rat by extract of Indigofera aspalathoides.
Topics: Animals; Chemoprevention; Diethylnitrosamine; Drug Synergism; Indigofera; Liver Neoplasms, Experimen | 2005 |
Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis.
Topics: Animals; Apoptosis; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; fas Receptor; He | 2005 |
[Pexoxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats].
Topics: Animals; Antineoplastic Agents; Chromans; Diethylnitrosamine; Ligands; Liver Neoplasms, Experimental | 2005 |
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility.
Topics: Animals; Apoptosis; Carcinogens; Cell Differentiation; Cell Proliferation; Cocarcinogenesis; Diethyl | 2005 |
[Development of a rat model for primary liver cancer with modified method].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms, Experimental; Male; Rats; Rats | 2004 |
Interferon-gamma-mediated hepatocarcinogenesis in mice treated with diethylnitrosamine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; Cyt | 2005 |
Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apium; Cell Proliferation; Diethylnitrosami | 2005 |
Deletion of Bid impedes cell proliferation and hepatic carcinogenesis.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Cell Cycle; Cell Death; Cel | 2005 |
Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms.
Topics: Administration, Oral; Animals; Apoptosis; Cell Proliferation; Connexins; Cytochrome P-450 Enzyme Sys | 2005 |
Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; Carcinogens; Cocarcinogenesis; Cytochrome P-450 CYP1A | 2005 |
Increased lung metastasis in transgenic NM23-Null/SV40 mice with hepatocellular carcinoma.
Topics: Animals; Antigens, Neoplasm; Antigens, Viral, Tumor; Biomarkers, Tumor; Blotting, Western; Chi-Squar | 2005 |
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasm | 2005 |
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.
Topics: Animals; Carcinogens; Cell Death; Cell Proliferation; Cell Transformation, Neoplastic; Cytokines; Di | 2005 |
Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzoquinones; Curcuma; Curcumin; Diethylnitrosamine; Li | 2005 |
Suppression of chemically-induced liver tumors by castration or estradiol-3-benzoate treatment in F344 rats.
Topics: Animals; Blotting, Western; Body Weight; Diethylnitrosamine; Estradiol; Estrogen Receptor alpha; Imm | 2005 |
Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Magnetic Resonance Im | 2005 |
Melatonin modulates the oxidant-antioxidant imbalance during N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Liver Neoplas | 2005 |
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Di | 2005 |
Effect of neonatal injection of sodium glutamate and diethylnitrosamine on hepatocarcinogenesis, reproductive and adrenocortical systems of male mice.
Topics: Adrenal Glands; Alkylating Agents; Animals; Animals, Newborn; Diethylnitrosamine; Female; Food Addit | 2005 |
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Cell Communication; Cocarcinogenesis; Con | 2005 |
Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cytochrome | 2006 |
Chemoprevention and cytotoxic effect of Bauhinia variegata against N-nitrosodiethylamine induced liver tumors and human cancer cell lines.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Bauhinia; Cell Line, Tumor; Diethylnitrosam | 2006 |
Effect of selenium-enriched malt on hepatocarcinogenesis, paraneoplastic syndrome and the hormones regulating blood glucose in rats treated by diethylnitrosamine.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Calcium; Carcinogens; Diethylnitrosamine; Edible | 2006 |
Species-specific effects of the hepatocarcinogens 3'-methyl-4-dimethyl-aminoazobenzene and ortho-aminoazotoluene in mouse and rat liver.
Topics: Animals; Carcinogens; Cell Nucleus; Diethylnitrosamine; Enzyme Induction; Glucocorticoids; Hepatocyt | 2005 |
The inhibitory effect of sodium selenite on N-nitrosodiethylamine-induced and phenobarbital promoted liver tumourigenesis in rats based on the modulation of polyamine levels.
Topics: alpha-Fetoproteins; Animals; Body Weight; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; | 2005 |
Amelioration of carcinogenesis and tumor growth in the rat liver by combination of vitamin K2 and angiotensin-converting enzyme inhibitor via anti-angiogenic activities.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cell Transformation, Neoplastic; Diethylnitrosami | 2006 |
Antioxidant activity of Terminalia arjuna bark extract on N-nitrosodiethylamine induced hepatocellular carcinoma in rats.
Topics: Alkylating Agents; Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Lipid Perox | 2006 |
[Ratio of low- and high-spin cytochrome P-450 in liver microsomes of N-nitrosodiethylamine-induced hepatomas].
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Sy | 2005 |
Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643.
Topics: Acyl-CoA Oxidase; Adenoma, Liver Cell; Animals; Apoptosis; Carcinogens; Cell Proliferation; Diethyln | 2006 |
Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis.
Topics: Animals; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Diethylnitrosamine; DN | 2006 |
Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Benzoquinones; Blood Cell Count; Carcinoge | 2006 |
Early induction of TGF-beta1 through a fasting-re-feeding regimen promotes liver carcinogenesis by a sub-initiating dose of diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Carcino | 2006 |
High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkylating Agents; Animals; Deoxyguanosine; Diethylnitrosamine; Disease | 2007 |
Alpha-ketoglutarate modulates the circadian patterns of lipid peroxidation and antioxidant status during N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Antioxidants; Catalase; Circadian Rhythm; Diethylnitrosamine; Glutathione; Glutathione Pero | 2006 |
[Induction of chemical hepatocarcinogenesis and establishment of orthotopic liver transplantation model with hepatocarcinoma in rats].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms, Experimental; Liver Transplant | 2006 |
Evaluation of possible mechanisms of protective role of Tamarix gallica against DEN initiated and 2-AAF promoted hepatocarcinogenesis in male Wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Liver; Liver Neoplasms, | 2006 |
Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Glutathione S-Transferase pi; Hepat | 2006 |
Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesis.
Topics: Animals; Apoptosis; Carcinogens; Cell Communication; Cell Proliferation; Connexin 26; Connexins; Die | 2006 |
Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Transformation, Neoplastic; Chemoprevention; Deoxyguanosi | 2006 |
Molecular basis of anticlastogenic potential of vanadium in vivo during the early stages of diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antimutagenic Agents; Chromosome Aberrations; Deoxyguanosine; | 2006 |
[Correlation of antitumor drug sensitivity between marrow mesenchymal stem cells (MSCs) and hepatocarcinoma cells in rats].
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cispla | 2006 |
Metabolic normalization of alpha-ketoglutarate against N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.
Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspartate Aminotransferases; Carbon Tetrachl | 2006 |
Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis.
Topics: Animals; Biomarkers, Tumor; Diethylnitrosamine; Gene Expression Profiling; Gene Expression Regulatio | 2006 |
Antiangiogenic effect of Lygodium flexuosum against N-nitrosodiethylamine-induced hepatotoxicity in rats.
Topics: 3,4-Methylenedioxyamphetamine; Alanine Transaminase; Angiogenesis Inhibitors; Angiopoietin-1; Angiop | 2006 |
A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Animals; Caffeic Acids; Carcinogens; Cell Proliferation; Cell Transformation, | 2006 |
Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinoma, Hepatocellular; Cocarcinogenesis; Diethylnitrosamine; DN | 2006 |
Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.
Topics: Analysis of Variance; Animals; Carcinogens; Cell Transformation, Neoplastic; Constitutive Androstane | 2007 |
Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Deoxyguan | 2007 |
Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice.
Topics: Animals; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA, Viral; Fe | 2007 |
Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin.
Topics: Animals; Antibiotics, Antineoplastic; Bone Marrow; Carbon Radioisotopes; Carcinoma, Hepatocellular; | 2007 |
Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; | 2007 |
Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats.
Topics: Animals; Binding, Competitive; Brain; Brain Stem; Carcinogens; Cell Proliferation; Cerebral Cortex; | 2007 |
Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay.
Topics: Animals; Carcinogens; Diet; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Hepatocytes; I | 2007 |
Expression of ErbB receptor proteins and TGF-alpha during diethylnitrosamine-induced hepatocarcinogenesis in the rat liver.
Topics: Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; ErbB Receptors; Glutath | 2007 |
Co-carcinogenic effect of cyclohexanol on the development of preneoplastic lesions in a rat hepatocarcinogenesis model.
Topics: Alkylating Agents; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Cyclohexanols; Diet | 2007 |
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2007 |
Effect of silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Antioxidants; Aspartate Ami | 2007 |
Global gene expression in Ha-ras and B-raf mutated mouse liver tumors.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Gene Expression; Gene Expression Profiling; Genes, r | 2007 |
Chemotherapeutic stress selectively activates NF-kappa B-dependent AKT and VEGF expression in liver cancer-derived endothelial cells.
Topics: Animals; Antigens, CD; Antimetabolites, Antineoplastic; Apoptosis; Cadherins; Cell Movement; Cells, | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
Lutein presents suppressing but not blocking chemopreventive activity during diethylnitrosamine-induced hepatocarcinogenesis and this involves inhibition of DNA damage.
Topics: Animals; Antineoplastic Agents; Body Weight; Diethylnitrosamine; DNA Damage; Liver; Liver Neoplasms, | 2007 |
Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Anticholesteremic Agents; Carcinogens; Clofibric Acid; Cocarcinogenesis; | 2007 |
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Estradiol; Female; Hepatocytes; Interleukin-6; Ku | 2007 |
Chemo-preventive effect of Star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepato-carcinogenesis.
Topics: Animals; Antioxidants; Body Weight; Cell Transformation, Neoplastic; Diethylnitrosamine; Erythrocyte | 2007 |
Decreased hepatic 5-HT1A receptors during liver regeneration and neoplasia in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Carcinogens; Cell Proliferation; Cells, Cultured; C | 2008 |
Potential of Vinca rosea extracts in modulating trace element profile: a chemopreventive approach.
Topics: Animals; Catharanthus; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mice; Plant Extracts | 2007 |
Enhancement of hepatocellular proliferative activity of kojic acid in mice by a simultaneous administration of ascorbic acid.
Topics: Animals; Antioxidants; Ascorbic Acid; Body Weight; Diethylnitrosamine; Drug Interactions; Immunohist | 2007 |
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Topics: Acetylcysteine; Animals; Antioxidants; Cocarcinogenesis; Diethylnitrosamine; Gene Expression Regulat | 2007 |
Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Body Weight; Carcinoembryonic Antigen; Carcinoma, Hepatoc | 2008 |
Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.
Topics: Animals; Animals, Genetically Modified; Carcinogens; Carcinoma, Hepatocellular; Cell Communication; | 2007 |
Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice.
Topics: Alkylating Agents; Animals; Apoptosis; Benzamides; Carcinoma, Hepatocellular; Cell Proliferation; Ch | 2008 |
Efficacy of doxorubicin coupled to lactosaminated albumin on rat hepatocellular carcinomas evaluated by ultrasound imaging.
Topics: Animals; Antibiotics, Antineoplastic; Diethylnitrosamine; Doxorubicin; Drug Carriers; Liver Neoplasm | 2008 |
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcinogens; Carcinoma, Hepatocel | 2007 |
Diuron lacks promoting potential in a rat liver bioassay.
Topics: Animals; Diethylnitrosamine; Diuron; Glutathione S-Transferase pi; Herbicides; Hexachlorobenzene; Im | 2007 |
beta-Naphthoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; beta-Naphthoflavone; Blotting, Western; Cell Proliferation; De | 2008 |
Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine.
Topics: Animals; Catalase; Cysteine; Diethylnitrosamine; Glutathione; Glutathione Peroxidase; Glutathione Tr | 2008 |
Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Growth Differe | 2008 |
Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkylating Agents; Animals; Body Weight; Carcinogens; Deoxyguanosine; D | 2008 |
Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Algorithms; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethy | 2008 |
Tumor promotion in liver of mice with a conditional Cx26 knockout.
Topics: Animals; Apoptosis; Carcinogens; Cocarcinogenesis; Connexin 26; Connexins; Diethylnitrosamine; Femal | 2008 |
24-hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or alpha-ketoglutarate.
Topics: Alanine Transaminase; alpha-Fetoproteins; Animals; Antioxidants; Aspartate Aminotransferases; Carcin | 2008 |
Two-dimensional differential gel electrophoresis/analysis of diethylnitrosamine induced rat hepatocellular carcinoma.
Topics: Animals; Base Sequence; Carcinogens; Chromatography, Liquid; Diethylnitrosamine; DNA Primers; Electr | 2008 |
Protective effects of Ginkgo biloba against rat liver carcinogenesis.
Topics: Animals; Biological Assay; Carcinogens; Diethylnitrosamine; Ginkgo biloba; Glutathione; Liver Neopla | 2008 |
Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Caffeic Acids; Cytochrome P-450 Enzyme Syst | 2008 |
Tomato oleoresin inhibits DNA damage but not diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Cell Proliferation; Chemopreventio | 2008 |
Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Dose-Response Relations | 2008 |
Transplanted bone marrow stromal cells are not cellular origin of hepatocellular carcinomas in a mouse model of carcinogenesis.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carcinoma, Hepatocellular; Cell Differentia | 2008 |
5-Azacytidine. Promoting activity for rat hepatocellular carcinoma.
Topics: Animals; Azacitidine; Carcinogens; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; R | 1984 |
Enzyme pattern and growth rate of liver preneoplastic clones during carcinogenesis by diethylnitrosamine.
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Clone Cells; Diethylnitrosamine; Glucose-6-Phos | 1984 |
Serum and hepatic enzyme activity in rats treated with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Female; Glucose-6-Phosphatase; Liver; Liver Neoplasms, Experimental; Ni | 1983 |
[Ultrastructure of human hepatic carcinomas compared with ultrastructural findings in hepatomas induced by chemical agents in Wistar rats and the golden hamster].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Cricetinae | 1983 |
[Enzymatic phenotype of preneoplastic islands induced in the rat liver by diethylnitrosamine].
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Live | 1983 |
Quantitative assessment of liver colony formation and hepatocellular carcinoma incidence in rats receiving intravenous injections of isogeneic liver cells isolated during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; | 1980 |
Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine.
Topics: Animals; Cell Division; Diethylnitrosamine; Ditiocarb; gamma-Glutamyltransferase; Hepatectomy; Histo | 1981 |
[Growth regulation and tumor promotion in the rat liver by steroid hormones].
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Castration; Cell Cycle; Cell Division; Clone Cells; | 1981 |
Promotive effects of deoxycholic acid on hepatocarcinogenesis initiated by diethylnitrosamine in male rats.
Topics: Animals; Carcinogens; Deoxycholic Acid; Diethylnitrosamine; Drug Synergism; gamma-Glutamyltransferas | 1981 |
Purification and transplantation of hepatocytes from livers of carcinogen-treated rats.
Topics: Animals; Cell Separation; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Liver; Li | 1982 |
Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Kinetics; Liver; Live | 1982 |
Progression of carcinogen-induced foci of gamma-glutamyltranspeptidase-positive hepatocytes to hepatomas in rats fed a choline-deficient diet.
Topics: 2-Acetylaminofluorene; Animal Feed; Animals; Cell Transformation, Neoplastic; Choline Deficiency; Di | 1982 |
Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol.
Topics: Animals; Cell Line; Cell Separation; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase | 1983 |
Modulation of tumor promotion in liver carcinogenesis.
Topics: Animals; Barbiturates; Carcinogens; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Di | 1983 |
The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Gluta | 1984 |
Effect of coadministration of phenobarbital sodium on N-nitrosodiethylamine-induced gamma-glutamyltransferase-positive foci and hepatocellular carcinoma in rats.
Topics: Animals; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Liver; Liver Neoplasms, E | 1984 |
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1983 |
Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Aggregation; Cell Nucleus; Diethylnitrosamine; Diploidy; DNA; F | 1984 |
Loss of lipid peroxidation as a histochemical marker for preneoplastic hepatocellular foci of rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Histocytochem | 1984 |
Enhancement of phenotypic instability by alpha-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Anisoles; Butylated Hydroxyanisole; Diethylnitrosamine; Eflornithine | 1984 |
Promotive effect of primary and secondary bile acids on the induction of gamma-glutamyl transpeptidase-positive liver cell foci as a possible endogenous factor for hepatocarcinogenesis in rats.
Topics: Animals; Bile Acids and Salts; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Live | 1984 |
Modifying potential of thirty-one chemicals on the short-term development of gamma-glutamyl transpeptidase-positive foci in diethylnitrosamine-initiated rat liver.
Topics: Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experim | 1984 |
The direct and indirect effects of promoters may depend upon the nature of the initiated cell.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DN | 1983 |
[Comparative systemic analysis of experimental models of chemical hepatic carcinogenesis in the rat].
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasm | 1984 |
Trichloroethylene effects on the formation of enzyme-altered foci in rat liver.
Topics: Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver | 1984 |
Failure to discriminate initiation from promotion of liver tumors in a long-term study with the phenobarbital-type inducer alpha-hexachlorocyclohexane and the role of sustained stimulation of hepatic growth and monooxygenases.
Topics: Animals; Diethylnitrosamine; DNA; Female; Hexachlorocyclohexane; Liver Neoplasms, Experimental; Orga | 1981 |
Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver.
Topics: Animals; Chlorobenzenes; Diet; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransfera | 1982 |
Presence of alpha-fetoprotein-positive cells in hepatocellular foci and microcarcinomas induced by single injections of diethylnitrosamine in infant mice.
Topics: alpha-Fetoproteins; Animals; Carcinoma; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experi | 1983 |
Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Rel | 1983 |
Histochemical localization of aldehyde dehydrogenase during rat hepatocarcinogenesis.
Topics: Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine; Female; Histocytochem | 1983 |
Effect of hexachlorocyclohexane on diethylnitrosamine-induced hepatocarcinogenesis in rat and its failure to promote skin tumors on dimethylbenz[a]anthracene initiation in mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Diethylnitrosamine; Drug Interactions | 1984 |
Isolation of preneoplastic rat liver cells by centrifugal elutriation and binding to asialofetuin.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins | 1984 |
[Mechanism of carcinogenesis. VII. Biosynthesis of carbamyl phosphate synthetase I in vivo and in vitro in hepatocellular carcinoma and liver of rats fed with diethylnitrosamine].
Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Diethylnitrosamine; In Vitro Techniqu | 1983 |
[Promoting effect of portacaval anastomosis in experimental hepatic carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver Neoplasms, Experimen | 1984 |
[Biosynthesis of CPSI from the liver of normal rats and and diethylnitrosamine-fed rats in rabbit reticulocyte lysate cell-free system].
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cell-Free System; Diethylnitrosamine; Ligases; Live | 1984 |
Alpha-1-antitrypsin in intracellular inclusions of diethylnitrosamine induced hepatomas of C57BLxC3H F1 mice.
Topics: alpha 1-Antitrypsin; Animals; Diethylnitrosamine; Fluorescent Antibody Technique; Inclusion Bodies; | 1980 |
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relation | 1981 |
Role of estrogens as promoters of hepatic neoplasia.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Diethylstilbestrol; Dose-Response Relationsh | 1982 |
Geno- and cytotoxicity of nitrosamines, aflatoxin B1, and benzo[a]-pyrene in continuous cultures of rat hepatoma cells.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Surviv | 1982 |
[Effects of apomorphine and haloperidol on experimental hepatocarcinogenesis].
Topics: Adenoma; Adenoma, Bile Duct; Animals; Apomorphine; Cell Transformation, Neoplastic; Diethylnitrosami | 1983 |
Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets.
Topics: Adenoma, Bile Duct; Amino Acids; Animals; Bile Duct Neoplasms; Choline Deficiency; Diet; Diethylnitr | 1983 |
Characterization of histochemically detectable altered hepatocyte foci and their relationship to hepatic tumorigenesis in rats treated once with diethylnitrosamine or benzo(a)pyrene within one day after birth.
Topics: Aging; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Diethylnitrosamine; Fem | 1984 |
[Nuclear nonhistone proteins of hepatomas and the liver in rats after the action of hepatic carcinogens and the operation of partial hepatectomy].
Topics: Animals; Antigens; Antigens, Neoplasm; Cell Nucleus; Chromosomal Proteins, Non-Histone; Diethylnitro | 1984 |
Correlation between time of partial hepatectomy after a single treatment with diethylnitrosamine and induction of adenosinetriphosphatase-deficient islands in rat liver.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Hepatectomy; Liver Neoplasms; Liver Neoplasm | 1980 |
Ferritin is increased in diethylnitrosamine-altered rat hepatocytes.
Topics: Adenosine Triphosphatases; Animals; Cells, Cultured; Diethylnitrosamine; Female; Ferritins; Fluoresc | 1981 |
Liver cell control after discontinuation of DENA feeding in hepatocarcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Growth Inhibitors; Homeostasis; Liver; | 1981 |
Functional alterations of the endoplasmic reticulum and the detoxification systems during diethyl-nitrosamine carcinogenesis in rat liver.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Endoplasmic | 1984 |
On mechanisms of sex differences in chemical carcinogenesis: effects of implantation of ectopic pituitary grafts on the early stages of liver carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Female; Hepatectomy; Hypothalamo-Hypophyseal Sys | 1984 |
Promotion of mouse liver neoplasms by the organochlorine pesticides chlordane and heptachlor in comparison to dichlorodiphenyltrichloroethane.
Topics: 2-Acetylaminofluorene; Animals; Chlordan; DDT; Diethylnitrosamine; Environmental Exposure; Heptachlo | 1984 |
Three-dimensional observations by scanning electron microscopy on the blood supply and organization of vasculature during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Micr | 1984 |
Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1984 |
[Effect of modification of the lipid bilayer on the functioning of the electron transport chain of endoplasmic reticulum membranes in nitrosodiethylamine-induced hepatic carcinogenesis].
Topics: Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Electron Transport; Endoplasmic Reticul | 1984 |
The role of central dopaminergic processes in chemical carcinogenesis.
Topics: Animals; Apomorphine; Autonomic Nervous System; Behavior, Animal; Cocarcinogenesis; Diethylnitrosami | 1984 |
Enhanced immunogenicity of line 10 guinea pig hepatocarcinoma cells after culture.
Topics: Animals; Cell Line; Cells, Cultured; Diethylnitrosamine; Female; Guinea Pigs; Immunity, Cellular; Li | 1983 |
Irreversibility of liver tumors in C3H mice.
Topics: Animals; Dieldrin; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; | 1984 |
Hepatocarcinogenicity of diethylnitrosamine to the self-fertilizing hermaphroditic fish Rivulus marmoratus (Teleostomi: Cyprinodontidae).
Topics: Aging; Animals; Cyprinidae; Diethylnitrosamine; Female; Hermaphroditic Organisms; Larva; Liver; Live | 1984 |
Decrease in L-type pyruvate kinase activity in rat liver by some promoters of hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride Poisoning; Carcinogens; Diethylnitrosamine; Isoenzymes; Isomerism; Liv | 1984 |
Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection.
Topics: Animals; Body Weight; Choline; Diet; Diethylnitrosamine; Drug Synergism; Folic Acid Deficiency; Live | 1984 |
Quantitative electron microscopic analysis of changes in peroxisomes and endoplasmic reticulum induced in mice during hepatocarcinogenesis by diethylnitrosamine promoted by di(2-ethylhexyl)phthalate or phenobarbital.
Topics: Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Endoplasmic Reticulum; Liver Neoplasms, Experim | 1984 |
Enzymic retrodifferentiation during hepatocarcinogenesis and liver regeneration in rats in vivo.
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Hepatectomy; Liver; Liver Neoplasms, E | 1983 |
Establishment of transplantable ascites hepatomas induced in ACI/N rats by N-diethylnitrosamine.
Topics: Animals; Ascites; Diethylnitrosamine; Guinea Pigs; Liver Neoplasms, Experimental; Neoplasm Transplan | 1983 |
Thermal denaturation studies on rat liver chromatin during diethylnitrosamine-induced hepatocarcinogenesis.
Topics: Animals; Chromatin; Deoxyribonucleoproteins; Diethylnitrosamine; Liver; Liver Neoplasms, Experimenta | 1984 |
Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Diethylnitrosamine; Female; Fetus; Glutathione Transferase; | 1984 |
Use of two sequential applications of initiators in the production of hepatomas in the rat: an examination of the Solt-Farber protocol.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Administration Schedule; Drug | 1984 |
Scanning electron microscopy of experimentally induced hepatocellular carcinoma.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Microscopy, Electron, Scanning; Mi | 1984 |
Scanning electron microscopy of experimentally induced sequential alterations of rat liver hyperplastic nodules.
Topics: Animals; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Microscopy, El | 1984 |
Correlated increase of the expression of the c-ras genes in chemically induced hepatocarcinomas.
Topics: Animals; Diethylnitrosamine; Female; Gene Expression Regulation; Liver Neoplasms, Experimental; Nucl | 1984 |
Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice.
Topics: Adenocarcinoma; Adenoma; Amobarbital; Animals; Body Weight; Diethylnitrosamine; Liver Neoplasms, Exp | 1984 |
Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Estradiol; Ethinyl Estradiol; Female; Liver N | 1984 |
Effects of sequential exposure to aflatoxin B1 and diethylnitrosamine on vascular and stomach tissue and additional target organs in rats.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Diethylnitrosamine; H | 1980 |
Promoting effects of polychlorinated biphenyls (Aroclor 1254) and polychlorinated dibenzofuran-free Aroclor 1254 on diethylnitrosamine-induced tumorigenesis in the rat.
Topics: Animals; Aroclors; Benzofurans; Body Weight; Carcinogens; Chlorodiphenyl (54% Chlorine); Cocarcinoge | 1981 |
Reduction of diethylnitrosamine-induced hepatoma in rats exposed to polychlorinated biphenyls through their dams.
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; Fetus; Liver; Liver Neoplasms, Experimental; | 1980 |
Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Diethylnitrosamine; Dimethyln | 1981 |
Failure of glutathione to prevent liver cancer development in rats initiated with diethylnitrosamine in the resistant hepatocyte model.
Topics: Animals; Antineoplastic Agents; Diethylnitrosamine; Drug Resistance; Glutathione; Liver; Liver Neopl | 1983 |
Delay of diethylnitrosamine-induced hepatoma in rats by carrot feeding.
Topics: Animals; Diet; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; | 1983 |
Changes in aldehyde dehydrogenase activity during diethylnitrosamine- or 2-acetylaminofluorene-initiated rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine | 1983 |
Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Liver N | 1983 |
Effect of simultaneous administration of clofibrate with diethylnitrosamine on hepatic tumorigenesis in the rat.
Topics: Animals; Clofibrate; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver N | 1983 |
Centrilobular distribution of diethylnitrosamine-induced hepatocellular foci in the mouse.
Topics: Animals; Diethylnitrosamine; Hepatic Veins; Liver Neoplasms, Experimental; Male; Mice; Portal Vein; | 1983 |
Kinetics of diethylnitrosamine hepatocarcinogenesis in the infant mouse.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Kinetics; Liver Neoplasms, Ex | 1983 |
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplas | 1983 |
Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Cell Division; Diethylnitrosamine; Liver Neopla | 1983 |
Intermediate-sized filaments in cultured rat liver tumor cells with Mallory body-like cytoplasm abnormalities.
Topics: Animals; Binding Sites; Cell Fractionation; Cells, Cultured; Concanavalin A; Cytoskeleton; Diethylni | 1980 |
Nonhistone protein changes during the diethylnitrosamine-induced carcinogenesis of rat liver.
Topics: Animals; Chromatin; Chromosomal Proteins, Non-Histone; Diethylnitrosamine; Liver Neoplasms, Experime | 1981 |
Immunohistochemical study of epoxide hydrolase during experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Epoxide Hydrolases; Histocytochemistry; Immunoen | 1981 |
[Use of radionuclides to study structural differences in mitochondrial and lysosomal membranes of normal and neoplastic cells].
Topics: Animals; Carcinoma, Ehrlich Tumor; Diethylnitrosamine; Gallium Radioisotopes; Indium; Intracellular | 1980 |
[Nonhistone proteins of the rat liver in malignant transformation by nitrosodiethylamine].
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA; DNA, Neoplasm; Liver; Liver Neopl | 1982 |
Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine.
Topics: Animals; Bile Acids and Salts; Carcinogens; Cortisone; Dexamethasone; Diethylnitrosamine; Ethinyl Es | 1982 |
Alterations of bioelectric potential in primary hepatocellular carcinomas induced by N-2-fluorenylacetamide or diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Electrophysiology; Female; Liver; Liver Neoplasm | 1982 |
Effects of various concentrations of ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) on diethylnitrosamine-induced hepatic tumorigenesis in the rat.
Topics: Animals; Body Weight; Clofibrate; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, | 1982 |
Tumor induction in C57BL X C3HF1 mice following single oral administration of diethylamine hydrochloride (DEA . HCl) and sodium nitrite (NaNO2).
Topics: Animals; Biotransformation; Diethylamines; Diethylnitrosamine; Drug Interactions; Liver; Liver Neopl | 1982 |
Induction of aldehyde dehydrogenases during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine | 1982 |
Quantitative analysis of the time-dependent development of glucose-6-phosphatase-deficient foci in the livers of mice treated neonatally with diethylnitrosamine.
Topics: Age Factors; Animals; Animals, Newborn; Castration; Diethylnitrosamine; Female; Glucosephosphate Deh | 1981 |
Infant mouse as a sensitive bioassay system for carcinogenicity of N-nitroso compounds.
Topics: Adenoma; Aging; Animals; Animals, Newborn; Biological Assay; Diethylnitrosamine; Dose-Response Relat | 1980 |
Presidential address. Recent concepts of initiation and promotion in carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; DNA; Humans; Intestinal Polyps; Liv | 1981 |
Proliferation of preneoplastic lesions after discontinuation of chronic DEN feeding in the development of hepatomas in rat.
Topics: Animals; Cell Count; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; Live | 1981 |
Inhibition of the hepatocarcinogenic activity of diethylnitrosamine (DENA) by ethanol in rats.
Topics: Animals; Diethylnitrosamine; Esophageal Neoplasms; Ethanol; Liver Neoplasms, Experimental; Male; Neo | 1981 |
Persistence of resistant putative preneoplastic hepatocytes induced by N-nitrosodiethylamine or N-methyl-N-nitrosourea.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Drug Resistance; Hepatectomy; Liv | 1980 |
[Effect of hydrazine sulfate on nucleic acid metabolism in rat liver tissue during the process of chemical hepatocarcinogenesis].
Topics: Animals; Diethylnitrosamine; DNA, Neoplasm; Drug Evaluation, Preclinical; Humans; Hydrazines; Liver; | 1980 |
[Progression of new transplantable hepatomas in C3HA strain mice. I. 61EP hepatomas].
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; M | 1980 |
Potent carcinogenicity of nitrosodiethanolamine in rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver Neoplasms, | 1980 |
Peroxidation in hepatomous liver of rats treated with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Glutathione; Lipid Peroxides; Liver; Liver Neoplasms, Experimental; Mal | 1980 |
Membrane and cytosolic protein phosphorylation patterns in the early stages of DEN-induced hepatocarcinogenesis in rats fed a high or low protein diet.
Topics: Animals; Dietary Proteins; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Membrane Protein | 1995 |
Growth characteristics and Ha-ras mutations of cell cultures isolated from chemically induced mouse liver tumours.
Topics: Animals; Cell Division; Codon; Diethylnitrosamine; Eosine Yellowish-(YS); Genes, ras; Liver Neoplasm | 1994 |
Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver.
Topics: Animals; Bacterial Toxins; Carcinogens; Diethylnitrosamine; Immediate-Early Proteins; Keratins; Live | 1994 |
TGF alpha differentially expressed in liver foci induced by diethylnitrosamine initiation and peroxisome proliferator promotion.
Topics: Animals; Carcinogens; Cell Division; Diethylnitrosamine; ErbB Receptors; Growth Substances; Liver; L | 1995 |
Gender-dependent differences in hepatic tumor promotion in diethylnitrosamine initiated infant B6C3F1 mice by alpha-hexachlorocyclohexane.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; DNA, Neoplasm; Drug Interactions; Female; Hex | 1995 |
Suppressive effect of molybdenum on hepatotoxicity of N-nitrosodiethylamine in rats.
Topics: Animals; Anticarcinogenic Agents; Calcium; Diethylnitrosamine; DNA; DNA Damage; Lipid Peroxidation; | 1995 |
Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Drug Synergism; Glutathione | 1995 |
Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltrans | 1995 |
Hepatocarcinogenesis in BXH recombinant inbred strains of mice: analysis of diverse phenotypic effects of the hepatocarcinogen sensitivity loci.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Disease Susceptibility; Eosinophils; Ethylnitroso | 1995 |
Promotion of N-nitrosodiethylamine-initiated hepatocellular tumors and hepatoblastomas by 2,3,7,8-tetrachlorodibenzo-p-dioxin or Aroclor 1254 in C57BL/6, DBA/2, and B6D2F1 mice.
Topics: Animals; Aroclors; Blotting, Western; Carcinogens; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 C | 1995 |
Ras-transduced diethylnitrosamine-treated hepatocytes develop into cancers of mixed phenotype in vivo.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Gene Transfer Techniques; Genes, ras; Hematopoiesis; | 1995 |
Initiation of hepatocarcinogenesis by endogenously formed N-nitrosobis(2-hydroxypropyl)amine, N-nitrosodiethanolamine and N-nitroso-2,6-dimethylmorpholine in rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; | 1995 |
Comparison of the effects of tamoxifen and toremifene on liver and kidney tumor promotion in female rats.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransfera | 1995 |
Persistence of TCDD-induced hepatic cell proliferation and growth of enzyme altered foci after chronic exposure followed by cessation of treatment in DEN initiated female rats.
Topics: Animals; Carcinogens; Cell Division; Diethylnitrosamine; Female; Glutathione Transferase; Liver; Liv | 1995 |
Nuclear lesions during rat hepatocarcinogenesis. I. Measuring the sister-chromatid exchanges during initiation, promotion and progression of rat hepatocarcinogenesis induced with diethylnitrosamine.
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; R | 1995 |
Nuclear lesions during rat hepatocarcinogenesis. II. Measuring the micronuclei during initiation, promotion and progression of rat hepatocarcinogenesis induced with diethylnitrosamine.
Topics: Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; Diethylnitrosamine; Hepatectomy; L | 1995 |
Effect of ovariectomy and sex hormone replacement on glutathione and glutathione-related enzymes in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Diethylnitrosamine; Estradiol; Female; Glutathi | 1995 |
Impairment of the mitochondrial respiratory chain activity in diethylnitrosamine-induced rat hepatomas: possible involvement of oxygen free radicals.
Topics: Animals; Antioxidants; Blotting, Southern; Diethylnitrosamine; DNA, Mitochondrial; Energy Metabolism | 1995 |
Phosphoinositide turnover during hepatocarcinogenesis induced by N-nitrosodiethylamine.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Diacylglycerol Kinase; Diethylnitrosamine; Diglycerides; I | 1995 |
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dim | 1995 |
GST-P-positive hepatocytes isolated from rats bearing enzyme-altered foci show no signs of p53 protein induction and replicate even when their DNA contains strand breaks.
Topics: Animals; Cells, Cultured; Diethylnitrosamine; DNA Damage; DNA Replication; Female; Glutathione Trans | 1995 |
Identification of clastogenic and/or aneugenic events during the preneoplastic stages of experimental rat hepatocarcinogenesis by fluorescence in situ hybridization.
Topics: Aneuploidy; Animals; Carbon Tetrachloride; Chromosome Aberrations; Diethylnitrosamine; In Situ Hybri | 1995 |
The enhancing effect of fasting/refeeding on the growth of nodules selectable by the resistant hepatocyte model in rat liver.
Topics: Animals; Diethylnitrosamine; Energy Intake; Fasting; Glutathione Transferase; Liver; Liver Neoplasms | 1995 |
The Hcr (hepatocarcinogen resistance) loci of DBA/2J mice partially suppress phenotypic expression of the Hcs (hepatocarcinogen sensitivity) loci of C3H/HeJ mice.
Topics: Animals; Chromosome Mapping; Diethylnitrosamine; Glycogen Storage Disease Type I; Liver Neoplasms, E | 1995 |
Lack of significant promoting activity by benzene in the rat liver model of carcinogenesis.
Topics: Animals; Benzene; Diethylnitrosamine; Disease Models, Animal; Drug Interactions; Liver Neoplasms, Ex | 1995 |
Development of a rat model for orthotopic liver transplantation for hepatocellular carcinoma.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Liver Transplantation; Male; Rats; Rats, | 1995 |
Effect of dietary fat on diethylnitrosamine induced hepatocarcinogenesis in Wistar rats.
Topics: Animals; Body Weight; Dietary Fats; Diethylnitrosamine; Fatty Acids; Lipid Peroxides; Liver Neoplasm | 1995 |
Flow cytometric DNA-ploidy and proliferative activity of diethylnitrosamine-induced hepatocellular carcinoma and pulmonary metastases in monkeys.
Topics: Animals; Cell Division; Chlorocebus aethiops; Diethylnitrosamine; DNA, Neoplasm; Flow Cytometry; Liv | 1995 |
Distribution and origin of the basement membrane component perlecan in rat liver and primary hepatocyte culture.
Topics: Animals; Antibodies, Monoclonal; Basement Membrane; Cell Adhesion; Cells, Cultured; Diethylnitrosami | 1993 |
Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Adenoma; Administration, Oral; Alpha-Globulins; Animals; Body Weight; Carcinoma, Renal Cell; Catecho | 1993 |
Identification of hepatocarcinogen-resistance genes in DBA/2 mice.
Topics: Animals; Carcinogens; Chromosome Mapping; Crosses, Genetic; Diethylnitrosamine; Drug Resistance; Fem | 1995 |
Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine.
Topics: Animals; Bromodeoxyuridine; Cell Division; Diethylnitrosamine; DNA, Neoplasm; Glutathione Transferas | 1995 |
Frequent loss of heterozygosity on chromosome 4 in diethylnitrosamine-induced C3H/MSM mouse hepatocellular carcinomas in culture.
Topics: Alleles; Animals; Base Sequence; Chromosomes; Diethylnitrosamine; Female; Gene Deletion; Genes, ras; | 1995 |
Expression of actin and desmin in experimentally induced hepatic lesions and neoplasms from medaka (Oryzias latipes).
Topics: Actins; Animals; Cholangiocarcinoma; Desmin; Diethylnitrosamine; Epithelium; Gene Expression; Liver; | 1995 |
Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Caseins; Diet; Diethylnitrosamine; gamma-G | 1995 |
Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Carcinogens; Diethylnitrosamine; F | 1995 |
Identification of an enhancer responsible for tumor marker gene expression by means of transgenic rats.
Topics: Animals; Animals, Genetically Modified; Base Sequence; Biomarkers, Tumor; Chloramphenicol O-Acetyltr | 1995 |
Liver tumour promoting activity of 3,4,5,3',4'-pentachlorobiphenyl and its interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy; Liver; Liver Neopl | 1995 |
Enhancing effects of organosulfur compounds from garlic and onions on hepatocarcinogenesis in rats: association with increased cell proliferation and elevated ornithine decarboxylase activity.
Topics: Acetyltransferases; Allium; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Garlic; Gl | 1994 |
Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl in rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Diterpenes; Drug Interact | 1995 |
Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis.
Topics: Administration, Oral; Agricultural Workers' Diseases; Animals; Body Weight; Diethylnitrosamine; Dise | 1995 |
The effect of deferoxamine on the preneoplastic lesions in the chemically induced hepatocarcinogenesis.
Topics: Animals; Deferoxamine; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Precancerous Conditi | 1994 |
[The expression of PCNA and EGF gamma in tumor cells of experimental hepatocellular carcinoma of liver and squamous cell carcinoma of stomach in rats].
Topics: Animals; Caffeine; Carcinoma, Squamous Cell; Diethylnitrosamine; ErbB Receptors; Liver Neoplasms, Ex | 1994 |
Further evidence for promoter-dependent development of hepatoblastoma in the mouse.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Hepatoblastoma; Liver Neoplasms, Experimental | 1995 |
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus.
Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease M | 1994 |
Effect of neutrons alone or combined with diethylnitrosamine on tumor induction in the livers of infant C57BL mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Ma | 1995 |
Analysis of calcium-dependent protein kinase C isoforms in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Cell Division; Chromatography; Diethylnitrosamine | 1993 |
Localization of oxidative damage by a glutathione-gamma-glutamyl transpeptidase system in preneoplastic lesions in sections of livers from carcinogen-treated rats.
Topics: Animals; Carcinogens; Catalase; Cell Membrane; Diethylnitrosamine; Female; Free Radical Scavengers; | 1994 |
[Inhibition of the protein kinase C-alpha gene overexpression in rat preneoplastic liver by selenium].
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regulation, Neoplastic; Huma | 1993 |
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regul | 1994 |
Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Clonorchiasis; Cricetinae; Cytochrome P-450 CYP2A6; Cytochro | 1994 |
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohi | 1994 |
c-Jun expression in single cells and preneoplastic foci induced by diethylnitrosamine in B6C3F1 mice: comparison with the expression of pi-class glutathione S-transferase.
Topics: Animals; Diethylnitrosamine; Female; Gene Expression; Genes, jun; Glutathione Transferase; Immunohis | 1994 |
Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Glutathione Transfe | 1994 |
In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.
Topics: Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; | 1994 |
Oncogene expression in hepatocytes of the fish Rivulus ocellatus marmoratus during the necrotic and regenerative phases of diethylnitrosamine toxicity.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; ErbB Receptors; Fishes; | 1994 |
Oncogene expression in hepatic and biliary neoplasms of the fish Rivulus ocellatus marmoratus: correlation with histologic changes.
Topics: Amino Acid Sequence; Animals; Biliary Tract Neoplasms; Diethylnitrosamine; Disease Models, Animal; E | 1994 |
Perturbations of endogenous levels of orotic acid and carcinogenesis: effect of an arginine-deficient diet and carbamyl aspartate on hepatocarcinogenesis in the rat and the mouse.
Topics: Animals; Arginine; Aspartic Acid; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Mi | 1994 |
Evaluation of the tumor-promoting activity of two beta-adrenoreceptor blocking agents, propranolol and atenolol, in liver of Fischer 344 rats.
Topics: Animals; Atenolol; Body Weight; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1994 |
Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Fem | 1994 |
Dose-dependent carcinogenicity and frequent Ki-ras proto-oncogene activation by dietary N-nitrosodiethylamine in rainbow trout.
Topics: Animals; Carcinogenicity Tests; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Gene E | 1994 |
Comparison of co-cultivation of V79 cells with rat hepatocytes and rat H4IIE hepatoma cells for studying nitrosamine-induced hprt gene mutations.
Topics: Animals; Biotransformation; Cells, Cultured; Cricetinae; Cricetulus; Culture Techniques; Diethylnitr | 1994 |
Studies of tamoxifen as a promoter of hepatocarcinogenesis in female Fischer F344 rats.
Topics: Animals; Carcinogens; Diet; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Rats; | 1994 |
Effects of novobiocin on the induction of gamma-glutamyltranspeptidase positive foci in the liver of rats treated with diethylnitrosamine.
Topics: ADP Ribose Transferases; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Enzyme Induction; gam | 1994 |
[The alteration of histidase catalytic activity and the expression of the enzyme protein in rat primary hepatomas].
Topics: Animals; Blotting, Western; Diethylnitrosamine; Female; Histidine Ammonia-Lyase; Liver Neoplasms, Ex | 1994 |
Simultaneous induction of liver cirrhosis and hepatocellular carcinomas in F-344 rats: establishment of a short hepatocarcinogenesis model.
Topics: Animals; Carbon Tetrachloride; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Hepatectomy; | 1994 |
Transforming growth factor-beta receptors type I, II and III in phenobarbital-promoted rat liver tumors.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Down-Regulation; Gene Expression Regulation, Neoplast | 1994 |
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neop | 1993 |
Growth hormone administration after treatment in the resistant hepatocyte model does not affect progression of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Body Weight; Cell Division; Diethylnitrosamine; Fem | 1994 |
Biochemical events during initiation of rat hepatocarcinogenesis.
Topics: Animals; Cell Division; Diethylnitrosamine; DNA; Glutathione Transferase; Guanine; Isoenzymes; Liver | 1994 |
Membrane and nuclear protein kinase C activation in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Cell Membrane; Cell Nucleus; Diethylnitrosamine; Enzyme Activation; Genes, ras; Isoenzymes; | 1994 |
Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; | 1994 |
22-Oxa-1,25(OH)2vitamin D3, a synthetic analogue of vitamin D3, has no promoting activity in a rat liver medium-term bioassay.
Topics: Animals; Antineoplastic Agents; Calcitriol; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Liver | 1994 |
Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Enzyme Inducti | 1994 |
The initiation-promotion-progression model of rat hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Benzene; Biomarkers, Tumor; Cells, Cultured; Diethylnitrosamine; | 1993 |
Evaluation of the promotion potential of chlorotrifluoroethylene trimer acid in male Sprague-Dawley rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Drug Synergism; Fatty Acids; gamma-Gluta | 1993 |
The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Gluta | 1993 |
Different effects of regenerative and direct mitogenic stimuli on the growth of initiated cells in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; | 1993 |
Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequen | 1993 |
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Gluta | 1993 |
Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; D | 1993 |
Interactive effects of unleaded gasoline and estrogen on liver tumor promotion in female B6C3F1 mice.
Topics: Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Estradiol; Estrogen Antagonists; Estrog | 1994 |
Screening for p53 mutations in C3H/He mouse liver tumors derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Topics: Animals; Base Sequence; Diethylnitrosamine; DNA, Neoplasm; DNA, Single-Stranded; Exons; Genes, p53; | 1994 |
[The inhibitory effects of epicatechin complex on diethylnitrosamine induced initiation of hepatocarcinogenesis in rats].
Topics: Animals; Catechin; Diethylnitrosamine; Genes, ras; In Situ Hybridization; Liver Neoplasms, Experimen | 1993 |
Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints.
Topics: Animals; Body Weight; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; G | 1993 |
[Promotive action of sodium fluoride on precancerous lesions of hepatocellular carcinoma induced by diethylnitrosamine (DEN) in rats--stereologic study of enzyme histochemistry].
Topics: Animals; Diethylnitrosamine; Fluoride Poisoning; Liver Neoplasms, Experimental; Male; Precancerous C | 1993 |
Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver.
Topics: Animals; Blotting, Northern; Cell Transformation, Neoplastic; Connexin 26; Connexin 43; Connexins; D | 1994 |
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1994 |
Enhancement by organosulfur compounds from garlic and onions of diethylnitrosamine-induced glutathione S-transferase positive foci in the rat liver.
Topics: Allium; Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Drug Synergism; Garlic; Glutathio | 1994 |
Ectopic pituitary grafts modify the response of male rats to sex differentiated promotion of diethylnitrosamine-initiated hepatic lesions with a choline-deficient diet.
Topics: Animals; Choline Deficiency; Cytochrome P-450 Enzyme System; Diet; Diethylnitrosamine; Disease Model | 1994 |
Changes in bile acids metabolism during rat hepatocarcinogenesis: causative or unrelated?
Topics: 2-Acetylaminofluorene; Animals; Bile Acids and Salts; Cholic Acid; Cholic Acids; Deoxycholic Acid; D | 1994 |
Effect of ethanol on paraquat toxicity in F344 rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Ethanol; Glutathione Transferas | 1994 |
The heterocyclic amines IQ and MeIQx show no promotive effect in a short-term in vivo liver carcinogenesis assay.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Diethylnitrosamine; Glutathione Transferase; | 1993 |
Promotion of preneoplastic lesions and induction of CYP2B by unleaded gasoline vapor in female B6C3F1 mouse liver.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Inducti | 1993 |
[The expression of C-myc, N-ras mRNA and its relations to the differentiation of preneoplastic altered hepatocytes].
Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Differentiation; Diethylnitrosam | 1993 |
Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Diethylnitrosamine; DNA; Liver; | 1993 |
Tissue protein turnover during liver carcinogenesis.
Topics: Animals; Cell Division; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Neoplasm Pro | 1993 |
Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats.
Topics: Acetylglucosaminidase; Animals; Butylated Hydroxyanisole; Carcinogens; Clofibrate; Diethylnitrosamin | 1993 |
Analbuminemia does not significantly influence hepatocarcinogenesis on comparing F344 rats and a congenic line carrying the analbuminemic mutation.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Diethylnitrosamine; DNA Primers; Liver Neoplasms, Exp | 1994 |
Effects of carbon tetrachloride, ethanol and acetaldehyde on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Acetaldehyde; Animals; Animals, Newborn; Body Weight; Carbon Tetrachloride; Diethylnitrosamine; Etha | 1993 |
Increased yield in GST-P-positive liver pre-neoplastic foci induced by DENA or ENU in rats pre-treated with estradiol or tamoxifen.
Topics: Animals; Cell Division; Diethylnitrosamine; Estradiol; Ethylnitrosourea; Female; Glutathione Transfe | 1993 |
Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors.
Topics: Animals; Base Sequence; Diethylnitrosamine; DNA, Neoplasm; DNA, Single-Stranded; Dose-Response Relat | 1993 |
Increasing the interval between initiation and the onset of exposure to orotic acid decreases its promoting effect on rat liver carcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver Neoplasms, Experimental; Male; Neopl | 1993 |
Chemopreventive effects of dietary D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, on initiation and postinitiation stages of diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; Drug Screening Assays, Antitumor; Eflornithine; Glutathione Transferase | 1993 |
Collaboration between growth factors and diverse chemical carcinogens in hepatocarcinogenesis of transforming growth factor alpha transgenic mice.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; ErbB Receptors; Female; Liver Neoplasms, Experimen | 1993 |
Further evidence of the tumor-suppressive effects of cadmium in the B6C3F1 mouse liver and lung: late stage vulnerability of tumors to cadmium and the role of metallothionein.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cadmium; Diethylnitrosamine; Liver; Liver Neoplasms, | 1993 |
Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Female; Liver; Liver | 1993 |
TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD.
Topics: Analysis of Variance; Animals; Cell Division; Cell Membrane; Diethylnitrosamine; Dose-Response Relat | 1993 |
A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis.
Topics: Animals; Body Weight; Diethylnitrosamine; Genetic Linkage; Liver Neoplasms; Liver Neoplasms, Experim | 1993 |
Sex-dependent expression of class pi glutathione S-transferase during chemical hepatocarcinogenesis in B6C3F1 mice.
Topics: Animals; Diethylnitrosamine; Female; Glutathione Transferase; Isoenzymes; Liver Neoplasms, Experimen | 1993 |
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Diethylnitrosamine; Li | 1993 |
Chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis by a simple phenolic acid protocatechuic acid in rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Administration Sche | 1993 |
Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats.
Topics: Animals; Body Weight; Captan; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Diethylnitrosami | 1993 |
Enhancement of GST-P positive liver cell foci development by a medium-term carcinogenicity bioassay using repeated administration of D-galactosamine.
Topics: 2-Acetylaminofluorene; Analysis of Variance; Animals; Biological Assay; Carcinogenicity Tests; Carci | 1995 |
CCAAT/enhancer-binding proteins alpha and beta interact with the silencer element in the promoter of glutathione S-transferase P gene during hepatocarcinogenesis.
Topics: Animals; Base Sequence; Carcinogens; CCAAT-Enhancer-Binding Proteins; Diethylnitrosamine; DNA-Bindin | 1995 |
[A comparative study of the synthesis of membrane hetero-organic antigens of kidney origin on tissue slices and isolated cells after a single carcinogenic exposure in rats].
Topics: Animals; Antigens, Heterophile; Antigens, Neoplasm; Antigens, Surface; Carcinogens; Culture Techniqu | 1995 |
Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Deoxyguanosine; Diethylnitrosamine; DNA; DNA Damage; Estradi | 1996 |
A novel clonality assay for the mouse: application to hepatocellular carcinomas induced with diethylnitrosamine.
Topics: Animals; Base Sequence; Carcinogens; Clone Cells; Diethylnitrosamine; DNA Primers; DNA, Neoplasm; Do | 1996 |
Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels.
Topics: Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; | 1996 |
Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Hepatocyte | 1996 |
Enhancement of thyroid and hepatocarcinogenesis by 1,4-bis[2-(3,5- dichloropyridyloxy)]benzene in rats at doses that cause maximal induction of CYP2B.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Liver Ne | 1996 |
Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; beta Carotene; Carcinogens; Carotenoids; Cytosol; Di | 1995 |
Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats.
Topics: Animals; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Pesticide | 1995 |
Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Humans; Iodine Radioisotope | 1996 |
Quantitative evaluation of lysozyme- and CD68-positive Kupffer cells in diethylnitrosamine-induced hepatocellular carcinomas in monkeys.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Carcinogens; Diethylnitrosamine; I | 1995 |
Chemopreventive effects of taurine on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; L | 1996 |
Disturbance of the cell cycle with colchicine enhances the growth advantage of diethylnitrosamine-initiated hepatocytes in rats.
Topics: Animals; Cell Cycle; Cell Division; Cocarcinogenesis; Colchicine; Diethylnitrosamine; Dose-Response | 1996 |
Soybean isoflavone extract suppresses early but not later promotion of hepatocarcinogenesis by phenobarbital in female rat liver.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Diethylnitrosamine; Female; gamma-Glutam | 1995 |
Isolation of up- and down-regulated cDNAs associated with hepatocellular carcinoma by a subtraction-enhanced display technique.
Topics: Animals; Base Sequence; Biomarkers, Tumor; Blotting, Northern; Diethylnitrosamine; DNA, Complementar | 1996 |
Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dose-Response Relation | 1996 |
Strain dependent effects of sex hormones on hepatocarcinogenesis in mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Glucose-6-Phosphatase; Liver Neoplasms, Experiment | 1996 |
A subnecrogenic dose of diethylnitrosamine is able to initiate hepatocarcinogenesis in the rat when coupled with fasting/refeeding.
Topics: Animals; Carcinogens; Diethylnitrosamine; Eating; Enzyme Induction; Fasting; gamma-Glutamyltransfera | 1996 |
Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogens; Cell Death; Cell Division; Diethylnitrosamine | 1996 |
The effect of tamoxifen and two of its non-isomerizable fixed-ring analogs on multistage rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Diethylnitrosamine; Dose-Response Relationship, Drug; | 1996 |
Expression of hepatocyte-enriched nuclear transcription factors in mouse liver tumours.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Facto | 1996 |
Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene.
Topics: Age Factors; Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; DNA, Viral; Dose-Response | 1996 |
Promotion potential of tamoxifen on hepatocarcinogenesis in female SD or F344 rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, | 1996 |
Low expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci induced in rat liver by diethylnitrosamine or phenobarbital.
Topics: Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diethylnitrosamine; Female; Gl | 1996 |
Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis.
Topics: Animals; Apoptosis; Carcinogens; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Liver Ne | 1996 |
Sinusoidal capillarization and arterial blood supply continuously proceed with the advance of the stages of hepatocarcinogenesis in the rat.
Topics: Animals; Capillaries; Carcinoma, Hepatocellular; Diethylnitrosamine; Factor VIII; Hyperplasia; Liver | 1996 |
In vivo cell lineage analysis during chemical hepatocarcinogenesis using retroviral-mediated gene transfer.
Topics: 2-Acetylaminofluorene; Animals; beta-Galactosidase; Biomarkers, Tumor; Carcinogens; Cell Count; Cell | 1996 |
Modeling the number and size of hepatic focal lesions following exposure to 2,3,7,8-TCDD.
Topics: Adenosine Triphosphate; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Respo | 1996 |
Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin.
Topics: Adenosine Triphosphatases; Animals; Apoptosis; Carcinogens; Cell Division; Diethylnitrosamine; Femal | 1996 |
Karyotypic changes in a multistage model of chemical hepatocarcinogenesis in the rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Diploidy; Disease Models, Animal; Female; gamma-Glutamyltr | 1996 |
Estrogen receptor levels and occupancy in hepatic sinusoidal endothelial and Kupffer cells are enhanced by initiation with diethylnitrosamine and promotion with 17alpha-ethinylestradiol in rats.
Topics: Animals; Carcinogens; Cell Nucleus; Cocarcinogenesis; Diethylnitrosamine; Endothelium; ErbB Receptor | 1996 |
Selective dieldrin promotion of hepatic focal lesions in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diethylnitrosamine; DNA, Neop | 1996 |
Contrast-enhanced MRI with gadodiamide injection in rat disease models.
Topics: Animals; Arterial Occlusive Diseases; Carcinogens; Cerebral Arterial Diseases; Cerebrovascular Disor | 1996 |
Allelotype analysis in mouse hepatocellular carcinomas; frequent homozygous deletion of mouse homolog of p16/CDKN2 gene on chromosome 4 in culture.
Topics: Alleles; Animals; Carrier Proteins; Chromosomes; Cyclin-Dependent Kinase Inhibitor p16; Diethylnitro | 1996 |
Dose-dependent induction of GST-P+ staining foci by the rat hepatocarcinogen methapyrilene in the medium-term bioassay.
Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Carcinogens; Diet; Diethylnitrosamine; Dose-R | 1996 |
Chemopreventive effects of green and black tea on pulmonary and hepatic carcinogenesis.
Topics: Adenoma; Administration, Oral; Analysis of Variance; Animals; Carcinogens; Diethylnitrosamine; Disea | 1996 |
[In situ expression of c-myc, N-ras during diethylnitrosamine induced hepatocarcinogenesis].
Topics: Animals; Diethylnitrosamine; Gene Expression; Genes, myc; Genes, ras; Liver Neoplasms, Experimental; | 1995 |
Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicine-induced cell cycle disturbance in partially hepatectomized rats.
Topics: Animals; Carcinogens; Cell Cycle; Cell Division; Cocarcinogenesis; Colchicine; Diethylnitrosamine; g | 1996 |
Hepatocyte expression of tumor associated aldehyde dehydrogenase (ALDH-3) and p21 Ras following diethylnitrosamine (DEN) initiation and chronic exposure to di(2-ethylhexyl)phthalate (DHEP).
Topics: Aldehyde Dehydrogenase; Animals; Biomarkers, Tumor; Carcinogens; Diethylhexyl Phthalate; Diethylnitr | 1996 |
Inhibition of tumor promotion and hepatocellular growth by dietary restriction in mice.
Topics: Animals; Apoptosis; Carcinogens; Cell Division; Diethylnitrosamine; Energy Intake; Liver Neoplasms, | 1996 |
[Expression of PCNA and protooncogenes during experimental hepatocarcinogenesis in rats].
Topics: Animals; Cell Count; Diethylnitrosamine; Gene Expression; Genes, ras; Liver Neoplasms, Experimental; | 1996 |
Transforming growth factor-alpha expression is altered during experimental hepatocarcinogenesis.
Topics: Animals; Blotting, Western; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Fema | 1996 |
Transforming growth factor-alpha in carcinogen-induced F344 rat hepatic foci.
Topics: Adenoma; Animals; Carcinoma; Coloring Agents; Diethylnitrosamine; DNA; Glutathione Transferase; Immu | 1996 |
Cell proliferation and regulation of negative growth factors in mouse liver foci.
Topics: Air Pollutants; Animals; Biomarkers, Tumor; Carcinogens; Cell Division; Diet; Diethylnitrosamine; Et | 1996 |
Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat.
Topics: Animals; Caprylates; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Glut | 1996 |
Cx32 gene mutation in a chemically induced rat liver tumour.
Topics: Adenoma; Animals; Carcinogens; Connexins; Diethylnitrosamine; Exons; Gap Junction beta-1 Protein; He | 1996 |
Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Glutathione Transferase; Liver Neopla | 1996 |
Alterations in enzymatic functions in hepatocytes and hepatocellular carcinomas from Ras-transduced livers resemble the effects of insulin.
Topics: 3T3 Cells; Animals; beta-Galactosidase; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; | 1996 |
Role of the pituitary in tumor promotion with ethinyl estradiol in rat liver.
Topics: Animals; Body Weight; Bromocriptine; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Estradiol Co | 1996 |
Lack of promoting activity of four pesticides on induction of preneoplastic liver cell foci in rats.
Topics: Animals; Carcinogens; Diazinon; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Organothiop | 1995 |
Hepatocyte growth factor levels in liver and serum increase during chemical hepatocarcinogenesis.
Topics: Animals; Antibodies, Monoclonal; Diethylnitrosamine; Female; Hepatocyte Growth Factor; Liver; Liver | 1996 |
Qualitative and quantitative analysis of AgNOR proteins in chemically induced rat liver carcinogenesis.
Topics: Animals; Bromodeoxyuridine; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Nuclear | 1996 |
Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Diethylnitrosamine; Drug Screening Assays, | 1996 |
Inhibitory effect of chlorophyllin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcinogens; Chlorophyllides; Diethylnitrosa | 1996 |
Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver.
Topics: Animals; Carcinogens; Clofibrate; Connexins; Diethylnitrosamine; gamma-Glutamyltransferase; Gap Junc | 1996 |
Methyl tertiary butyl ether lacks tumor-promoting activity in N-nitrosodiethylamine-initiated B6C3F1 female mouse liver.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Methyl Ether | 1996 |
The cancer-promoting potential of fumonisin B1 in rat liver using diethylnitrosamine as a cancer initiator.
Topics: Animals; Carboxylic Acids; Carcinogens, Environmental; Diethylnitrosamine; Drug Synergism; Fumonisin | 1996 |
Differential expression of c-jun and c-myc in N-nitroso diethylamine-induced hepatic oncogenesis in AKR mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Genes, jun; Genes, | 1996 |
Activation of ras oncogenes during hepatocarcinogenesis induced by N-nitrosodiethylamine: possible involvement of PKC and GAP.
Topics: Animals; Carcinogens; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Genes, ras; GTP Ph | 1996 |
[Intensity of liver tumor promotion effects in rats given repeated oral administrations of benzimidazole compounds].
Topics: Administration, Oral; Animals; Anthelmintics; Benzimidazoles; Diethylnitrosamine; Dose-Response Rela | 1996 |
Suppressive effects of S-methyl methanethiosulfonate on promotion stage of diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Diethylnitrosamine; Lipid Peroxidation; Liver Neoplasms, Experimen | 1997 |
Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Adenoviridae; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Ganciclovir; Gene Transfer Tec | 1997 |
Rat ferritin-H: cDNA cloning, differential expression and localization during hepatocarcinogenesis.
Topics: Animals; Base Sequence; Blotting, Northern; Carcinogens; Diethylnitrosamine; DNA, Complementary; Fer | 1997 |
Quantitative stereological studies of a 'selection' protocol of hepatocarcinogenesis following initiation in neonatal male and female rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Carcinogens; Diethylni | 1997 |
Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Dieth | 1997 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Hepatic tumor induction in c-myc mono-transgenic and TGF-alpha/c-myc double-transgenic mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms, Experimental; Mice; Mice, Transgenic; Phe | 1997 |
Changes in protein kinase C alpha, delta and in nuclear beta isoform expression in tumour and lung metastatic nodules induced by diethylnitrosamine in the rat.
Topics: Animals; Cadherins; Carcinogens; Cell Nucleus; Diethylnitrosamine; Isoenzymes; Liver Neoplasms, Expe | 1997 |
Glutathione metabolism in hepatomous liver of rats treated with diethylnitrosamine.
Topics: Animals; Biological Transport; Cysteine; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione; | 1997 |
Vitamin E modulation of hepatic focal lesion growth in mice.
Topics: Animals; Apoptosis; Bromodeoxyuridine; Carcinogens; Cell Count; Cell Division; Diethylnitrosamine; D | 1997 |
Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis.
Topics: Aged; Animals; Carcinogens; Carcinoma, Hepatocellular; Carrier Proteins; Cholesterol; Diethylnitrosa | 1997 |
Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice.
Topics: Animals; Blotting, Northern; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Genes, myc; | 1997 |
Studies on the proliferative activity of diethylnitrosamine-induced hepatocellular carcinomas in monkeys.
Topics: Adenoma; Animals; Carcinogens; Cell Division; Chlorocebus aethiops; Diagnosis, Differential; Diethyl | 1997 |
[The role of platelet-derived growth factor and ras P21 in experimental hepatocarcinogenesis].
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Platelet-Derived Growth Fac | 1996 |
S-methylcysteine and cysteine are inhibitors of induction of glutathione S-transferase placental form-positive foci during initiation and promotion phases of rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cysteine; Diethylnitrosamine; Gene Expression; Genes, | 1997 |
[Gene expression of HGF and its receptor in experimental hepatomas].
Topics: Animals; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Liver | 1996 |
High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32.
Topics: Animals; Blotting, Northern; Bromodeoxyuridine; Carcinogens; Connexins; Diethylnitrosamine; Female; | 1997 |
Sparse distribution of hepatocyte growth factor-producing cells inside hepatocellular foci in rats treated with hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Hepatocyte | 1997 |
Long term dietary indole-3-carbinol inhibits diethylnitrosamine-initiated hepatocarcinogenesis in the infant mouse model.
Topics: Administration, Oral; Aging; Animals; Anticarcinogenic Agents; Breast Neoplasms; Carcinogens; Diethy | 1997 |
Beta-carotene inhibits rat liver chromosomal aberrations and DNA chain break after a single injection of diethylnitrosamine.
Topics: Animal Nutritional Physiological Phenomena; Animals; Anticarcinogenic Agents; Antioxidants; beta Car | 1997 |
Resistance of Copenhagen rats to chemical induction of glutathione S-transferase 7-7-positive liver foci.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Resistance; Enzyme Induction; | 1997 |
Corn oil enhances gamma-glutamyl transpeptidase-positive foci development in the presence of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Carcinogens; Corn Oil; Dietary Fats, Unsaturated; Diethylnitrosamine; Dinoprost; Fatty Acid | 1997 |
Hepatic foci in rats after diethylnitrosamine initiation and 2,3,7,8-tetrachlorodibenzo-p-dioxin promotion: evaluation of a quantitative two-cell model and of CYP 1A1/1A2 as a dosimeter.
Topics: Animals; Apoptosis; Carcinogens; Computer Simulation; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1 | 1997 |
Liver tumour-promoting effects of oxfendazole in rats.
Topics: Administration, Oral; Animals; Anthelmintics; Benzimidazoles; Carcinogens; Cell Count; Cocarcinogene | 1997 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogen | 1997 |
Prohibitin expression is decreased in the regenerating liver but not in chemically induced hepatic tumors in rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Immunohistochemistry; Liver; Liver Neoplasms, Expe | 1997 |
Suppressive effect of oestradiol on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Estradiol; Femal | 1998 |
Enhanced expression of a new class of liver-enriched b-Zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Carcinogens; Carcinoma, Hepatocellular; Cell Di | 1998 |
Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carotenoids; Chemoprevention; Colonic Neoplasms; Diethy | 1997 |
Suppressive effect of irsogladine maleate on diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis in male F344 rats.
Topics: Animals; Antineoplastic Agents; Diethylnitrosamine; Glutathione Transferase; Immunohistochemistry; L | 1998 |
Tumor recurrence in liver grafts: two animal models.
Topics: Animals; Diethylnitrosamine; Liposarcoma; Liver Neoplasms; Liver Neoplasms, Experimental; Liver Tran | 1998 |
Initiation and promotion of altered hepatic foci in female rats and inhibition of cell-cell communication by the imidazole fungicide prochloraz.
Topics: Animals; Body Weight; Carcinogens; Cell Communication; Cell Line; Diethylnitrosamine; Epithelial Cel | 1998 |
Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression.
Topics: Acetylglucosamine; Animals; Carcinogens; Diethylnitrosamine; Disease Progression; Female; Genetic Ve | 1998 |
Identification of glutathione S-transferase p-1 as the class pi form dominantly expressed in mouse hepatic adenomas.
Topics: Adenoma; Animals; Diethylnitrosamine; Escherichia coli; Female; Glutathione Transferase; Liver Neopl | 1998 |
Protective role of Trianthema portulacastrum against diethylnitrosoamine-induced experimental hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Drinking Behavior; Feeding Behavi | 1998 |
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers, Tumor; Carcinogens; Cytochrome P-450 CYP2A6; Cyt | 1998 |
Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship | 1998 |
Loss of a putative novel growth inhibitory apoptotic 14 kD polypeptide during progression of rat liver carcinogenesis.
Topics: Animals; Apoptosis; Carcinogens; Diethylnitrosamine; Immunohistochemistry; Liver; Liver Neoplasms, E | 1998 |
Time course of cell cycle-related protein expression in diethylnitrosamine-initiated rat liver.
Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cyclin-Dependent Kinases; Cyclins; Dieth | 1998 |
Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Biopsy, Needle; Carcinoma, Hepatocellular; Diethylnitros | 1998 |
Beta-carotene reduces the ductular (oval) cell reaction in the liver of Wistar rats submitted to the resistant hepatocyte model of carcinogenesis.
Topics: 2-Acetylaminofluorene; Actins; Animals; beta Carotene; Bile Ducts, Intrahepatic; Collagen; Diethylni | 1998 |
Interactive effects of three structurally different polychlorinated biphenyls in a rat liver tumor promotion bioassay.
Topics: Animals; Body Weight; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Diethylnitrosamine; Dose-Res | 1998 |
Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats.
Topics: Animals; Arachidonic Acid; Corn Oil; Dietary Fats, Unsaturated; Diethylnitrosamine; Dinoprost; Docos | 1998 |
Prevention by 1'-acetoxychavicol acetate of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form-positive, focal lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet.
Topics: Amino Acids; Animals; Anticarcinogenic Agents; Benzyl Alcohols; Carcinogens; Choline; Diet; Diethyln | 1998 |
Enhanced in vivo adenovirus-mediated gene transfer to rat hepatocarcinomas by selective administration into the hepatic artery.
Topics: Adenoviridae; Animals; beta-Galactosidase; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expre | 1998 |
Hepatocellular carcinoma is induced by a subnecrogenic dose of diethylnitrosamine in previously fasted-refed rats.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Dru | 1998 |
Role of the thymus in successful transplantation of rat hepatoma cells.
Topics: Animals; Diethylnitrosamine; Graft Survival; Kidney; Liver; Liver Neoplasms, Experimental; Neoplasm | 1998 |
Effects of endogenous N-nitrosodiethylamine and blocking of its synthesis with ascorbic acid on the condition of the liver monooxygenase system.
Topics: Animals; Antioxidants; Ascorbic Acid; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamin | 1998 |
Environmental complex mixture toxicity assessment.
Topics: Adenoma, Liver Cell; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Chromat | 1998 |
Medium-term bioassays for carcinogenicity of chemical mixtures.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dr | 1998 |
Promoting activity of the herbicide dicamba (2-methoxy-3, 6-dichlorobenzoic acid) in two stage hepatocarcinogenesis.
Topics: Acyl-CoA Oxidase; Adenosine Triphosphatases; Animals; Dicamba; Diethylnitrosamine; Female; Glucose-6 | 1999 |
Inhibition of early-phase exogenous and endogenous liver carcinogenesis in transgenic rats harboring a rat glutathione S-transferase placental form gene.
Topics: Animals; Animals, Genetically Modified; Choline Deficiency; Diet; Diethylnitrosamine; Glutathione Tr | 1998 |
Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Diethylnitrosamine; Disease Models, Animal; | 1999 |
The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice.
Topics: Alternative Splicing; Animals; Carcinogens; Diethylnitrosamine; DNA; Female; Hepatocyte Growth Facto | 1999 |
Trianthema portulacastrum restores the antioxidant defense enzyme levels and hepatic biotransformation patterns in experimental rat hepatocarcinogenesis.
Topics: Animals; Carcinogens; Chloroform; Cytochrome P-450 Enzyme System; Cytosol; Diethylnitrosamine; Ethan | 1998 |
Modulating effects of diets high in omega-3 and omega-6 fatty acids in initiation and postinitiation stages of diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Corn Oil; Diet, Fat-Restricted; Dietary Fats, | 1999 |
Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis, and antioxidation.
Topics: Animals; Antioxidants; Apoptosis; Body Weight; Carbon Tetrachloride; Carcinogens; Cell Division; Die | 1999 |
Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; Liver; Liver Function Tests; Liver Neoplasms, Experimental | 1999 |
Beta-catenin mutations are frequent in hepatocellular carcinomas but absent in adenomas induced by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; beta Catenin; Carcinoma, Hepatocellular; Cytoskeletal Proteins; Diethylnitrosamine | 1999 |
Macrophage and hepatic stellate cell responses during experimental hepatocarcinogenesis.
Topics: Actins; Animals; Carcinogens; Diethylnitrosamine; Female; Glial Fibrillary Acidic Protein; Immunohis | 1998 |
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Cell Transformation, Neoplastic; Chloroform; Diethylnitro | 1999 |
Progression of hepatic neoplasia in medaka (Oryzias latipes) exposed to diethylnitrosamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms, Experimental; Neoplasm Metastasis; Oryzia | 1999 |
Progressive changes of the nuclear matrix protein composition in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Antigens, Nuclear; Carcinogens; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; M | 1999 |
Phenobarbital-induced cytoplasmic accumulation of beta1-integrin in rat liver enzyme altered foci; an immunohistological study.
Topics: Animals; Animals, Newborn; Bromodeoxyuridine; Carcinogens; Cytoplasm; Diethylnitrosamine; Female; Gl | 1998 |
Liver cancer is induced by a subnecrogenic dose of DENA when associated with fasting/refeeding: role of glutathione-transferase and lipid peroxidation.
Topics: Animals; Antioxidants; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Eating; Fasting; Fatty Aci | 1999 |
Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Bromodeoxyuridine; Cell Division; Diethylnitrosamine; Glu | 1999 |
Maternal or paternal exposure to radiation increases susceptibility to the induction of glutathione S-transferase-positive hepatic foci in offspring rats.
Topics: Animals; Body Weight; Carcinogens; Cell Division; Diethylnitrosamine; Disease Susceptibility; Enzyme | 1998 |
Oral administration of cholic acid promotes growth of liver tumors initiated by diethylnitrosamine in rats.
Topics: Administration, Oral; Animals; Apoptosis; Carcinogens; Cell Division; Cholic Acid; Diethylnitrosamin | 1999 |
The tumor promoting effect of constant light exposure on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Body Temperature; Body Weight; Carcinogens; Circadian Rhythm; Diethylnitrosamine; Laparotom | 1999 |
Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats.
Topics: Animals; Blotting, Northern; Body Weight; Cell Division; Crosses, Genetic; Diethylnitrosamine; DNA; | 1999 |
Effect of nodularin on the expression of glutathione S-transferase placental form and proliferating cell nuclear antigen in N-nitrosodiethylamine initiated hepatocarcinogenesis in the male Fischer 344 rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Hyperplasia; Liver; Liver Neoplas | 1999 |
Development of resistance during the early stages of experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Resistan | 1999 |
Characterization of selective induction and alteration of xenobiotic biotransforming enzymes by vanadium during diethylnitrosamine-induced chemical rat liver carcinogenesis.
Topics: Animals; Antineoplastic Agents; Biotransformation; Carcinogens; Diethylnitrosamine; Drug Screening A | 1999 |
Effects of dietary iron overload on progression in chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Ch | 1999 |
Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.
Topics: Amino Acids; Animals; beta Catenin; Carcinogens; Choline Deficiency; Cytoskeletal Proteins; Diet; Di | 1999 |
Inhibitory effect of Trianthema portulacastrum L. diethylnitroso-amine-induced phenobarbital promoted hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diethylnitrosamine; Drinking Behavior; E | 1999 |
Elevation of metallothionein level in preneoplastic lesions during chemical hepatocarcinogenesis of the Fischer 344 rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms; Liver | 1999 |
Further evidence of the usefulness of bile acids as molecules for shuttling cytostatic drugs toward liver tumors.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Bile Acids and Salts; Cells, Cultured; Cispla | 1999 |
Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10.
Topics: Animals; Carcinogens; Chromosome Mapping; Crosses, Genetic; Diethylnitrosamine; Female; Genetic Mark | 1999 |
Effect of fasting/refeeding on the incidence of chemically induced hepatocellular carcinoma in the rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Food; Incidence; Liver Neoplasms, Experimental; Lung Neopl | 1999 |
Regulation of selection of liver nodules initiated with N-nitrosodiethylamine and promoted with nodularin injections in fischer 344 male rats by reciprocal expression of transforming growth factor-beta1 and its receptors.
Topics: Alkylating Agents; Animals; Blotting, Northern; Diethylnitrosamine; Gene Expression Regulation, Neop | 1999 |
Beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats.
Topics: Adenoma; Amino Acid Substitution; Animals; beta Catenin; Binding Sites; Carcinogenicity Tests; Carci | 1999 |
The relationship between decrease in Cx32 and induction of P450 isozymes in the early phase of clofibrate hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Clofibrate; Connexins; Cytochrome P-450 En | 1999 |
Diethylnitrosamine exposure-responses for DNA ethylation, hepatocellular proliferation, and initiation of carcinogenesis in rat liver display non-linearities and thresholds.
Topics: Animals; Carcinogens; Cell Division; Diethylnitrosamine; DNA Adducts; DNA Damage; Dose-Response Rela | 1999 |
Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats.
Topics: Animals; Diet; Diethylnitrosamine; Dinoprostone; Female; Lipid Peroxidation; Liver Neoplasms, Experi | 1999 |
Apoptosis and cell proliferation are involved in the initiation of liver carcinogenesis by a subnecrogenic dose of diethylnitrosamine in refed rats.
Topics: Analysis of Variance; Animals; Apoptosis; Autoradiography; Body Weight; Cell Division; Diethylnitros | 2000 |
Effects of Fas-mediated liver cell apoptosis on diethylnitrosamine-induced hepatocarcinogenesis in mice.
Topics: Adenoma; Alkylating Agents; Animals; Antibodies, Monoclonal; Apoptosis; Cell Transformation, Neoplas | 2000 |
Suppression of apoptosis in C3H mouse liver tumors by activated Ha-ras oncogene.
Topics: Animals; Apoptosis; Cell Division; Codon; Diethylnitrosamine; Gene Expression Regulation, Neoplastic | 2000 |
Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Biomarkers; Carcinogens; | 2000 |
Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Diethylnitr | 1999 |
The use of fractal features from the periphery of cell nuclei as a classification tool.
Topics: Animals; Animals, Newborn; Cell Nucleus; Chromatin; Diethylnitrosamine; Fractals; Image Enhancement; | 1999 |
Diet restriction increases ubiquinone contents and inhibits progression of hepatocellular carcinoma in the rat.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Apoptosis; Carcinogens; Cell Division; Diethylnitrosam | 2000 |
Comparative hepatocarcinogenicity of hexachlorobenzene, pentachlorobenzene, 1,2,4,5-tetrachlorobenzene, and 1,4-dichlorobenzene: application of a medium-term liver focus bioassay and molecular and cellular indices.
Topics: Animals; Carcinogenicity Tests; Chlorobenzenes; Cytochrome P-450 Enzyme System; Diethylnitrosamine; | 2000 |
Evaluation of HSV-tk gene therapy in a rat model of chemically induced hepatocellular carcinoma by intratumoral and intrahepatic artery routes.
Topics: Adenoviridae; Animals; Diethylnitrosamine; Ganciclovir; Genetic Therapy; Hepatic Artery; Humans; Liv | 2000 |
Implication of Bcl-2 family genes in basal and D-amphetamine-induced apoptosis in preneoplastic and neoplastic rat liver lesions.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Coloring Agents; Dextroamphetamine; Diethylnitrosami | 2000 |
Bile acid secretion during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Bile; Carcinoma, Hepatocellular; Cell Differ | 2000 |
[The expression of mutant p53 (mp53) protein in rat hepatic preneoplastic lesions induced by diethylnitrosamine (DEN)].
Topics: Animals; Diethylnitrosamine; Glutathione Transferase; Immunohistochemistry; Liver Neoplasms, Experim | 1997 |
Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrosodiethylamine or a choline-deficient L-amino acid-defined diet in rats.
Topics: Animals; Carcinogens; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diethylnit | 2000 |
Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Administration Schedule; Female; | 2000 |
Genome-wide loss of heterozygosity analysis of chemically induced rat hepatocellular carcinomas reveals elevated frequency of allelic imbalances on chromosomes 1, 6, 8, 11, 15, 17, and 20.
Topics: Alleles; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation, Neoplas | 2000 |
Fibronectin and malignant disease-associated DNA-binding protein 2 in hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Biomarkers, Tumor; Diethylnitrosamine; DNA-Binding Proteins; Fibronectin | 2000 |
Antioxidant and anticarcinogenic activity of Lycovin--an indigenous herbal preparation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Diethylnitrosamine; In Vitro Techniques; L | 1999 |
New evidence for an extra-hepatic role of N-acetylglucosaminyltransferase III in the progression of diethylnitrosamine-induced liver tumors in mice.
Topics: Alleles; Animals; Blotting, Northern; Blotting, Southern; Blotting, Western; Diethylnitrosamine; Dis | 2000 |
Cancer chemopreventive activity of an iridoid glycoside, 8-acetylharpagide, from Ajuga decumbens.
Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogens; Diethylnitrosamine; Female; Glucosid | 2000 |
Overexpression of G1/S cyclins and PCNA and their relationship to tyrosine phosphorylation and dephosphorylation during tumor promotion by metanil yellow and malachite green.
Topics: Animals; Azo Compounds; Cyclins; Diethylnitrosamine; Food Coloring Agents; G1 Phase; Liver Neoplasms | 2000 |
Mouse strain susceptibility to diethylnitrosamine induced hepatocarcinogenesis is cell autonomous whereas sex-susceptibility Is due to the micro-environment: analysis with C3H <--> BALB / c sexually chimeric mice.
Topics: Animals; Antibodies; Carcinogens; Chimera; Cocarcinogenesis; Diethylnitrosamine; Female; Genetic Mar | 2000 |
Chemopreventive effects of coumaperine from pepper on the initiation stage of chemical hepatocarcinogenesis in the rat.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Cell Division; Coumarins; Diethylnitrosami | 2000 |
Enhancing effects of Thai edible plants on 2-amino-3, 8-dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diet; Diethylnitrosamine; Drug Synergism; Glutathione T | 2000 |
Further evidence for chemopreventive potential of beta-carotene against experimental carcinogenesis: diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by beta-carotene than by retinoic acid.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; beta Carotene; Carcinogens; Diethylnitrosamine; | 2000 |
Differential modulation of xenobiotic metabolizing enzymes by vanadium during diethylnitrosamine-induced hepatocarcinogenesis in Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Cyt | 2000 |
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3) inhibit diethylnitrosamine-induced rat liver carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Calcitriol; Carcinogens; Cytochrome P-450 Enzyme System; Cytosol; | 2000 |
Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Connexins; Crosses, Genetic; Diethylnitrosamine; Drug Synerg | 2000 |
Enhancement of chemical hepatocarcinogenesis by the HIV-1 tat gene.
Topics: Adenoma, Liver Cell; Animals; Basophils; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; | 2000 |
Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; gamma-Glutamyltransferase | 2000 |
Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3).
Topics: Animals; Antineoplastic Agents; Calcitriol; Chromosome Aberrations; Diethylnitrosamine; DNA Damage; | 2000 |
Enhancement of hepatocarcinogenesis initiated with diethylnitrosamine or N-nitrosobis(2-hydroxypropyl)amine by a choline-deficient, L-amino acid-defined diet administered prior to the carcinogen exposure in rats.
Topics: Amino Acids; Animals; Choline Deficiency; Diet; Diethylnitrosamine; Glutathione Transferase; Liver N | 2000 |
A blood-tumor barrier limits gene transfer to experimental liver cancer: the effect of vasoactive compounds.
Topics: Actins; Adenoviridae; Angiotensin II; Animals; Diethylnitrosamine; Extracellular Matrix; Fibronectin | 2000 |
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
Topics: Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ethanol; Female | 2000 |
Long-term dehydroepiandrosterone and 16alpha-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesions in liver of diethylnitrosamine-initiated rats.
Topics: Animals; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Diet; Diethylnitrosamine; DNA; DNA Repli | 2001 |
[Correlation study of TGF beta expression in diethylnitrosamine-induced rat liver cancer and mast cells in its vicinity].
Topics: Animals; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms, Exper | 2000 |
Chemoprevention of lung cancer by lycopene.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Caroteno | 2000 |
Suppression of chemical carcinogenesis by water-soluble organosulfur compounds.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Cysteine; Diethylnitrosamine; Hepate | 2001 |
[The influence of Kupffer cells on experimental hepatocarcinogenesis].
Topics: Animals; Diethylnitrosamine; Gadolinium; Gene Expression; Genes, myc; Kupffer Cells; Liver Neoplasms | 1998 |
Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogens; Catalase; D | 2001 |
Role of immunosuppression in recurrence after liver transplantation for diethylnitrosamine-induced tumors in rats.
Topics: Animals; Cyclosporine; Diethylnitrosamine; Graft Survival; Immunosuppressive Agents; Liver Neoplasms | 1994 |
Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Cinnamates; Dieth | 2000 |
A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay.
Topics: Animals; Biological Assay; Body Weight; Calibration; Carcinogens; Cell Count; Cell Division; Chlorob | 2001 |
Possible prevention by abieslactone of development of diethylnitrosamine-initiated GST-P positive foci in the rat liver.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Body Weight; Chemoprevention; Diethylnitrosamin | 2001 |
Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carci
Topics: Animals; Base Sequence; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Ki | 2001 |
Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.
Topics: Animals; Animals, Newborn; Apoptosis; Bromodeoxyuridine; Cell Division; Diethylnitrosamine; Female; | 2001 |
Suppression of altered hepatic foci development by a high fish oil diet compared with a high corn oil diet in rats.
Topics: alpha-Tocopherol; Animals; Corn Oil; Cytochrome P-450 CYP2B1; Diethylnitrosamine; Dinoprostone; Fema | 2000 |
Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Cocarcinogenesis; Deoxyguanosine; Diethylnitrosam | 2001 |
Nuclear Ras: unexpected subcellular distribution of oncogenic forms.
Topics: Alkyl and Aryl Transferases; Animals; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell | 2001 |
Further experiments on lipid peroxidation in transplanted and experimental hepatomas.
Topics: Aminopyrine N-Demethylase; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Cytosol; Diethylnit | 1984 |
Reaction of fumonisin with glucose prevents promotion of hepatocarcinogenesis in female F344/N rats while maintaining normal hepatic sphinganine/sphingosine ratios.
Topics: Alkylating Agents; Animals; Biomarkers; Carboxylic Acids; Diethylnitrosamine; Female; Fumonisins; Gl | 2001 |
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Female; Gene Dosage; Gene | 2001 |
Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Amino Acid Sequence; Animals; Base Sequence; Carcinogens; | 2001 |
Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16(Ink4a), p19(Arf), p53, and p21(Waf1/Cip1).
Topics: Alkylating Agents; Animals; Blotting, Western; Cellular Senescence; Cyclin-Dependent Kinase Inhibito | 2001 |
[Inhibitory effect of methanol extract of Boschniakia rossica Fedtsch. et Flerov on rat hepatic preneoplastic lesions induced by diethylnitrosamine].
Topics: Animals; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diethylnitrosamine; Drugs, Chinese Herbal; | 1998 |
Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters.
Topics: Adenoviridae; Alkylating Agents; Animals; Anticonvulsants; beta-Galactosidase; Carcinoma, Hepatocell | 2001 |
The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility.
Topics: Animals; Bromodeoxyuridine; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Gene | 2001 |
Immunohistochemical characterization of hepatoblastomas in B6C3F1 mice treated with diethylnitrosamine and sodium phenobarbital.
Topics: Albumins; Alkylating Agents; alpha-Fetoproteins; Animals; Diethylnitrosamine; Immunohistochemistry; | 2001 |
Effect of alpha-tocopherol on hepatocarcinogenesis in transforming growth factor-alpha (TGF-alpha) transgenic mice treated with diethylnitrosamine.
Topics: Alkylating Agents; alpha-Tocopherol; Animals; Antioxidants; Chemoprevention; Diethylnitrosamine; Liv | 2001 |
Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Citric Acid Cycle; Dietary Supplements; Diethyl | 2001 |
Anticarcinogenic effect of red ginseng on the development of liver cancer induced by diethylnitrosamine in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Data Interpretation, Statistical; Dieth | 2001 |
Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors.
Topics: Animals; Base Sequence; beta Catenin; Carcinogens; Cell Division; Clone Cells; Cytoskeletal Proteins | 2001 |
The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposed to human-relevant doses.
Topics: Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Female; | 2001 |
Effect of metanil yellow and malachite green on DNA synthesis in N-nitrosodiethylamine induced preneoplastic rat livers.
Topics: Animals; Azo Compounds; Blotting, Western; Cell Division; Coloring Agents; Cyclins; Diethylnitrosami | 2001 |
Effects of fasting and intermittent fasting on rat hepatocarcinogenesis induced by diethylnitrosamine.
Topics: Alkylating Agents; Animals; Basophils; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progre | 2002 |
Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine.
Topics: Alkylating Agents; Animals; Autocrine Communication; Carcinoma, Hepatocellular; Diethylnitrosamine; | 2002 |
Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls.
Topics: Animals; Apoptosis; Cell Division; Diethylnitrosamine; DNA-Binding Proteins; Electrophoretic Mobilit | 2002 |
Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32-deficient mice.
Topics: Animals; Carcinogens; Connexins; Diethylnitrosamine; Gap Junction beta-1 Protein; Liver Neoplasms, E | 2002 |
[Effects of sex hormones on the expression of placenta form glutathione S-transferase (GST-P) in rat induced hepatocarcinoma].
Topics: 2-Acetylaminofluorene; Animals; Castration; Diethylnitrosamine; Estradiol; Female; Glutathione Trans | 1998 |
Cancare-a herbal formulation inhibits chemically induced tumours in experimental animals.
Topics: Animals; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Methylcholanthrene; Mice; Mice, | 2001 |
Inhibitory effects of lemon grass (Cymbopogon citratus, Stapf) extract on the early phase of hepatocarcinogenesis after initiation with diethylnitrosamine in male Fischer 344 rats.
Topics: Animals; Anticarcinogenic Agents; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Liver Ne | 2002 |
Glucocorticoid binding and response in rat liver and diethylnitrosamine (DENA)-induced hepatomas.
Topics: Adrenalectomy; Animals; Cell Nucleus; Corticosterone; Cytosol; Dexamethasone; Diethylnitrosamine; Li | 1978 |
Sequential analysis of hepatic carcinogenesis: the comparative architecture of preneoplastic, malignant, prenatal, postnatal and regenerating liver.
Topics: Animals; Diethylnitrosamine; Fetus; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; | 1979 |
Differences in serum alpha-fetoprotein concentrations during the carcinogenic sequences resulting from exposure to diethylnitrosamine or acetylaminofluorene.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Diethylnitrosamine; Fluorenes; Liver Neoplasms, | 1979 |
Effects of a choline-devoid diet on the emergence of gamma-glutamyltranspeptidase-positive foci in the liver of carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Aspartate Aminotransferases; Choline Deficiency; | 1979 |
Rat alpha-macrofetoprotein (acute-phase alpha 2-macroglobulin) during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; alpha-Macroglobulins; Animals; Diethylnitrosamine; Liver | 1979 |
Effect of phenobarbital, dichlorodiphenyltrichloroethane, and polychlorinated biphenyls on diethylnitrosamine-induced hepatocarcinogenesis.
Topics: Animals; DDT; Diethylnitrosamine; Drug Synergism; Enzyme Induction; Liver Neoplasms, Experimental; M | 1979 |
Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3'-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms, Expe | 1978 |
Cell kinetics of hepatocytes during the preneoplastic period of diethylnitrosamine-induced liver carcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Cell Division; Diethylnitrosamine; Kinetics; Liver Neoplasms, Ex | 1979 |
Prolonged induction of hepatic ornithine decarboxylase and its relation to cyclic adenosine 3':5'-monophosphate-dependent protein kinase activation after a single administration of diethylnitrosamine.
Topics: Animals; Carboxy-Lyases; Cyclic AMP; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Ac | 1979 |
Carcinogen-induced abnormalities in rat liver cells and their modification by chemical agents.
Topics: Animals; Butyrates; Cell Line; Cell Nucleus; Cytoplasm; Diethylnitrosamine; Dimethyl Sulfoxide; Huma | 1979 |
Changes in hexokinase properties during transformation and subsequent proliferation of liver cells.
Topics: Animals; Diethylnitrosamine; Hexokinase; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inb | 1979 |
Effects of discontinuation of chronic feeding of diethylnitrosamine on the development of hepatomas in adult rats.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Nitrosamines; Precancerous Conditi | 1979 |
Alkylation of DNA and RNA by [14C]dimethylnitrosamine in hydroxyurea-synchronized regenerating rat liver.
Topics: Alkylation; Animals; Cell Cycle; Diethylnitrosamine; DNA; Guanine; Hydroxyurea; Liver; Liver Neoplas | 1979 |
Carcinogenesis in tissue culture 30: malignant transformation of normal rat liver cells treated with diethylnitrosamine in tissue culture with special reference to the differential effects of cytochalasin B on various cells with and without tumorigenicity
Topics: Animals; Animals, Suckling; Cell Nucleus; Cell Transformation, Neoplastic; Culture Techniques; Cytoc | 1979 |
Radio-iron uptake of rat hepatoma.
Topics: Animals; Diethylnitrosamine; Iron; Iron Radioisotopes; Liver; Liver Neoplasms, Experimental; Male; R | 1979 |
[Comparative investigations on the organotropic carcinogenic effect of different N-nitroso compounds with rat after single and chronic treatment (author's transl)].
Topics: Animals; Benzyl Compounds; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Female; Ki | 1979 |
Sequential changes in DNA polymerases alpha and beta during diethylnitrosamine-induced carcinogenesis.
Topics: Animals; Diethylnitrosamine; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Female; Liver | 1979 |
In vitro characteristics of two established hepatoma cell lines.
Topics: Animals; Cell Line; Diethylnitrosamine; Epithelium; Fibroblasts; Liver Neoplasms, Experimental | 1978 |
Cellular responses to surface binding and internalization of concanavalin A. An electron microscopic investigation on the problem of membrane cycling.
Topics: Animals; Cell Membrane; Concanavalin A; Diethylnitrosamine; Endocytosis; Golgi Apparatus; Liver; Liv | 1978 |
Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.
Topics: Acetates; Animals; Cell Division; Clofibrate; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopl | 1978 |
mRNA levels of catalytic subunits of protein phosphatases 1, 2A, and 2C in hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Ph | 1992 |
Potential protective effect of vitamin C on carcinogenesis caused by nitrosamine in drinking water: an experimental study on Wistar rats.
Topics: Adenoma, Bile Duct; Animals; Anticarcinogenic Agents; Ascorbic Acid; Chi-Square Distribution; Diethy | 1992 |
The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined diets.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA Pro | 1992 |
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Division; Clofibrate; Diethylhexyl Phtha | 1992 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Gluta | 1992 |
Threshold dose dependence in phenobarbital promotion of rat hepatocarcinogenesis initiated by diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glutathion | 1992 |
Ethanol ingestion combined with lowered carbohydrate intake enhances the initiation of diethylnitrosamine liver carcinogenesis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cocarcinogenesis; Dietary Carbohydrates; | 1992 |
Modification of DENA-induced hepatocarcinogenesis by CCl4 cirrhosis. Comparison of the marker enzyme patterns.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Drug Administrati | 1992 |
Role of diethylnitrosamine, 2-acetylaminofluorene and partial hepatectomy in the expression of glutathione-S-transferase-P and gamma-glutamyltranspeptidase in the early steps of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Transfera | 1992 |
[Dose-response relationship of promotion by phenobarbital in rat two-stage hepatocarcinogenesis].
Topics: Administration, Oral; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms | 1991 |
Liver transplantation for diethylnitrosamine-induced hepatocellular carcinoma in rats.
Topics: Animals; Cyclosporine; Cytotoxicity, Immunologic; Diethylnitrosamine; Graft Survival; Liver Neoplasm | 1992 |
Proline dithiocarbamate inhibits N-nitrosodiethylamine induced liver carcinogenesis.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Diethylnitrosamine; Disulfiram; Diti | 1992 |
Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats.
Topics: Allyl Compounds; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Diethylnitrosamine; Disulfide | 1992 |
Progressive atypia in spontaneous and N-nitrosodiethylamine-induced hepatocellular adenomas of C3H/HeNCr mice.
Topics: Aging; Animals; Body Weight; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Male; | 1992 |
[Characteristics and biologic significance of changes in DNA content of rat liver cells during hepatocarcinogenesis].
Topics: Aneuploidy; Animals; Diethylnitrosamine; Diploidy; DNA; DNA, Neoplasm; Flow Cytometry; Liver; Liver | 1992 |
Magnetic resonance imaging, microangiography, and histology in a rat model of primary liver cancer.
Topics: Animals; Contrast Media; Diethylnitrosamine; Disease Models, Animal; Liver; Liver Neoplasms, Experim | 1992 |
Medium-term carcinogenicity bioassay.
Topics: Animals; Biological Assay; Biomarkers, Tumor; Carcinogenicity Tests; Diethylnitrosamine; Genes, ras; | 1992 |
Absence of mutations in the functional parts of the p120-GAP gene in carcinogen-induced mouse liver tumors.
Topics: Animals; Base Sequence; Diethylnitrosamine; Genes, ras; GTPase-Activating Proteins; Liver Neoplasms, | 1992 |
Mechanisms of the enhanced liver carcinogenesis by choline in female rats: delay in liver growth after partial hepatectomy and stimulation of 2-AAF mitoinhibition.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline; Diethylnitrosamine; DNA, Neoplasm; Drug Inte | 1992 |
Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat.
Topics: Animals; Barbiturates; Body Weight; Cocarcinogenesis; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzy | 1992 |
Characteristic changes of DNA stemlines during hepatocarcinogenesis in rats.
Topics: Aneuploidy; Animals; Diethylnitrosamine; Diploidy; DNA, Neoplasm; Liver Neoplasms, Experimental; Mal | 1992 |
Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Enzyme Induction; Glutathione Trans | 1992 |
Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.
Topics: 2-Acetylaminofluorene; Adenoma; Aminobiphenyl Compounds; Animals; Base Sequence; Carcinoma; Diethyln | 1992 |
Transforming growth factor-alpha expression in rat experimental hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; Ethinyl Estradiol; Female; Immunohistochemistry; Liver Neoplasms, Exper | 1992 |
An enzyme-linked immunosorbent assay for p65 oncofetal protein and its potential as a new marker for cancer risk assessment in rodents and humans.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Choline; Choline Deficiency; Diethylni | 1992 |
Choline enhances acetylaminofluorene promotion of liver carcinogenesis in female but not in male rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Choline; Diethylnitrosamine; Drug Synergism; F | 1992 |
Enzyme and immunohistochemical phenotyping of diethylnitrosamine-induced liver lesions of male C3H/He, B6C3F1 and C57BL/6J mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Immunohistochemistry; Isoenzymes; Liver | 1992 |
Cytogenetic changes in hepatocarcinomas from rats treated with chronic exposure to diethylnitrosamine.
Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Diethylnitrosamine; Karyotyping; Liver Neoplas | 1992 |
Activation of the Ha-, Ki-, and N-ras genes in chemically induced liver tumors from CD-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diethylnitrosamine; DNA Mutational Analysis; DNA, Neoplas | 1992 |
Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzym | 1992 |
Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Leukocyte Count; Liver Neoplasms, Experimental; Male; Merc | 1992 |
Changes in lipid content and composition during the development of N-nitrosodiethylamine induced hepatocarcinoma.
Topics: Animals; Cholesterol; Diethylnitrosamine; DNA; Lipid Metabolism; Liver Neoplasms, Experimental; Male | 1992 |
Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses.
Topics: Animals; Antioxidants; Benzodioxoles; Body Weight; Bromodeoxyuridine; Butylated Hydroxyanisole; Cate | 1992 |
Stimulation of NADH oxidase activity from rat liver plasma membranes by growth factors and hormones is decreased or absent with hepatoma plasma membranes.
Topics: Animals; Cell Membrane; Cell Separation; Diethylnitrosamine; Epidermal Growth Factor; Glucagon; Grow | 1992 |
[The expression of hetero-organic antigens of kidney origin on the surfaces of cultured rat hepatocytes under the influence of the narrow-band fractions of non-histone chromosomal proteins].
Topics: Animals; Antigens, Heterophile; Antigens, Neoplasm; Antigens, Surface; Cells, Cultured; Chromosomal | 1992 |
Variant protein patterns in hepatomas and transformed liver cell lines as determined by high resolution two-dimensional gel electrophoresis (2DE).
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Electropho | 1992 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
Lack of effects of viral sialoadenitis and depletion of epidermal growth factor on initiation of hepatic carcinogenesis in the rat.
Topics: Animals; Antibodies, Viral; Cell Transformation, Neoplastic; Coronaviridae; Coronaviridae Infections | 1991 |
Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.
Topics: Animals; Cell Division; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Estrogens; Female; gamma | 1991 |
Aneuploidy and progression in promoted preneoplastic foci during chemical hepatocarcinogenesis in the rat.
Topics: Aneuploidy; Animals; Biomarkers, Tumor; Diethylnitrosamine; DNA; DNA, Neoplasm; gamma-Glutamyltransf | 1991 |
Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Biomarkers, Tumor; Carcinogens; Diethylnit | 1991 |
Synthetic estrogens and tamoxifen as promoters of hepatocarcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Replication; Dose-Response Relationship, Drug; Drug An | 1991 |
Estrogen receptor, epidermal growth factor receptor and cellular ploidy in elutriated subpopulations of hepatocytes during liver tumor promotion by 17 alpha-ethinylestradiol in rats.
Topics: Animals; Body Weight; Cell Count; Cell Division; Cell Fractionation; Cell Separation; Diethylnitrosa | 1991 |
Mechanisms of fat-related modulation of N-nitrosodiethylamine-induced tumors in rats: organ distribution, blood lipids, enzymes and pro-oxidant state.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biotransformation; Body Weight; Cell Mem | 1991 |
Enhancing effect of malachite green on the development of hepatic pre-neoplastic lesions induced by N-nitrosodiethylamine in rats.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Glycogen; Liver; Liver Neo | 1991 |
Effect of dietary fat on the initiation of hepatocarcinogenesis by diethylnitrosamine or 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Dietary Fats; Diethylnitrosamine; Female; | 1991 |
A reduction in mixed function oxidases and in tumor promoting effects of ethanol in a NDEA-initiated hepatocarcinogenesis model.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Ethanol; gamma-Glutamyltransferase; Liver Neoplasms, | 1991 |
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Anemia, Hypochromic; Animals; Body Weight; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltrans | 1991 |
Promotion of rat hepatocarcinogenesis by praziquantel.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carcinogens; Diethylnitrosa | 1991 |
Effects of polychlorinated biphenyls in rat liver: quantitative analysis of enzyme-altered foci.
Topics: Adenosine Triphosphatases; Animals; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Diet | 1991 |
Utilization of circulating glutathione by nodular and cancerous intact rat liver.
Topics: Animals; Bile Ducts; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione; Liver; Liver Neopla | 1991 |
[The expression of alpha 1-inhibitor 3 gene and some changes of its structure in rat hepatomas].
Topics: Acute-Phase Proteins; Animals; Diethylnitrosamine; DNA Transposable Elements; Female; Gene Expressio | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis.
Topics: Adenosine; Animals; Azacitidine; Biomarkers, Tumor; Deoxyadenosines; Diethylnitrosamine; gamma-Gluta | 1991 |
Enhanced expression of low molecular weight keratins during progressive diethylnitrosamine-induced hepatocarcinogenesis in rats is associated with the presence of high levels of gamma-glutamyl transpeptidase and glycogen-deficient islands.
Topics: Animals; Biomarkers, Tumor; Cell Differentiation; Diethylnitrosamine; gamma-Glutamyltransferase; Ker | 1991 |
Growth kinetics of microscopic hepatocellular neoplasms in carcinogen-resistant and carcinogen-responsive strains of mice.
Topics: Animals; Carcinogens; Cell Division; Diethylnitrosamine; DNA, Neoplasm; Liver Neoplasms; Liver Neopl | 1992 |
Changes in alanine transport in plasma membrane vesicles from rat liver during the early stages of diethylnitrosamine-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Alanine; Animals; Biological Transport; Cell Membrane; Diethylnitrosamine; He | 1992 |
Adenylate cyclase activity in crude liver membranes during chemical hepatocarcinogenesis in portacaval shunted rats.
Topics: 2-Acetylaminofluorene; Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Diethylnitrosamine; Glu | 1992 |
Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Topics: Animals; Base Sequence; Blotting, Southern; Codon; Diethylnitrosamine; DNA; Gene Expression; Genes, | 1991 |
Synergistic enhancement of glutathione S-transferase placental form-positive hepatic foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses.
Topics: Amines; Animals; Body Weight; Carcinogenicity Tests; Carcinogens, Environmental; Diethylnitrosamine; | 1991 |
Spongiosis hepatis: chemical induction, pathogenesis, and possible neoplastic fate in a teleost fish model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyprinidae; Diethylnitrosamine; Disease Models, Ani | 1991 |
Sex comparison of heme pathway in rats bearing hepatic tumors.
Topics: 5-Aminolevulinate Synthetase; Animals; Carboxy-Lyases; Cytochrome P-450 Enzyme System; Diethylnitros | 1991 |
[Effects of ginseng on hepatocellular carcinoma in rats induced by diethylnitrosamine--a further study].
Topics: Animals; Diethylnitrosamine; Drugs, Chinese Herbal; Liver Neoplasms, Experimental; Male; Microscopy, | 1991 |
The effects of alternating dietary restriction and ad libitum feeding of mice on the development of diethylnitrosamine-induced liver tumours and its correlation to insulinaemia.
Topics: Adenoma; Animals; Body Weight; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Eating; Female; | 1991 |
Histochemical profile of mouse hepatocellular adenomas and carcinomas induced by a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Glucosephosphate Dehy | 1991 |
Relationship between dose and risk reduction: statistical evaluation of a combination experiment with three hepatocarcinogenic N-nitrosamines in rats.
Topics: Age Factors; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Combin | 1991 |
Development and use of monoclonal antibodies against an oncofetal protein associated with carcinogenesis and tumorigenesis.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Biomarkers, Tumor; Blotting, Western; Diethylni | 1991 |
Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
Topics: Animals; Capsaicin; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Lung Neopla | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion.
Topics: Aflatoxin B1; Aflatoxins; Animals; Antioxidants; Carcinogens; Diethylnitrosamine; DNA; Indoles; Live | 1991 |
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; | 1991 |
Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis.
Topics: Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Diethylnitrosamine; Drug Synergism; Liv | 1991 |
[Immunohistochemical observation on the proliferative activity of rat liver in early hepatocarcinogenesis].
Topics: Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Diethylnitrosamine; Female; Hyperplasia; Immunoh | 1991 |
Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose-response study.
Topics: Animals; Bile Duct Neoplasms; Carcinogenicity Tests; Diethylnitrosamine; Dimethylnitrosamine; Dose-R | 1991 |
Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine.
Topics: Age Factors; Animals; Carcinogenicity Tests; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response | 1991 |
Chronic nitrosamine ingestion in 1040 rodents: the effect of the choice of nitrosamine, the species studied, and the age of starting exposure.
Topics: Age Factors; Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Esophageal N | 1991 |
Dose-dependent enhancing effects of quinacrine on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in male F344 rats.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Synergism; Eating; Enzyme Induct | 1991 |
Molecular genetic analysis of preneoplastic and neoplastic liver lesions in the mouse.
Topics: Animals; Diethylnitrosamine; DNA Mutational Analysis; DNA, Neoplasm; Genes, ras; Liver Neoplasms, Ex | 1991 |
Rat hepatocarcinogenesis induced by N-nitrosodiethylamine and N-nitrosomorpholine continuously administered at low doses. From basophilic areas of hepatocytes to hepatocellular tumors.
Topics: Adenoma; Administration, Oral; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, | 1991 |
Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransfera | 1990 |
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gluta | 1990 |
Immunofluorescent analysis of gamma-glutamyl transpeptidase and glutathione-S-transferase-P during the initial phase of experimental hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; Fluorescent Antibody Technique; gamma-Glutamyltransferase; Glutathione | 1990 |
Dose-response relationships in promotion of rat hepatocarcinogenesis by 17 alpha-ethinylestradiol.
Topics: Animals; Cholesterol; Diethylnitrosamine; Dose-Response Relationship, Drug; Ethinyl Estradiol; Femal | 1990 |
Proto-oncogene and gap-junction protein expression in rodent liver neoplasms.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gene Expression Re | 1990 |
Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Deoxycholic Acid; Diethylnitrosam | 1990 |
Diamine oxidase activity in a model of multistep hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Amine Oxidase (Copper-Containing); Animals; Diethylnitrosamine; gamma-Glutamy | 1990 |
Modulation by indomethacin or prostaglandin E2 of the incidence of diethylnitrosamine-induced gamma-glutamyltranspeptidase-positive foci in rat liver.
Topics: Animals; Diethylnitrosamine; Dinoprostone; gamma-Glutamyltransferase; Hepatectomy; Indomethacin; Liv | 1990 |
Promotion of hepatocellular foci in female rats by chenodeoxycholic acid.
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Diethylnitrosamine; Female; Glutathione Transf | 1991 |
Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Ethylnitrosourea; Gene Expression Regulation, Neo | 1991 |
The correlation of body growth with diethylnitrosamine-induced hepatocarcinogenesis in relation to serum insulin and somatomedin-C.
Topics: Animals; Body Weight; Caffeine; Diethylnitrosamine; Eating; Fasting; Injections, Intraperitoneal; In | 1991 |
Cyclosporine enhances the growth of carcinogen-induced enzyme-altered foci in rat liver.
Topics: Animals; Carcinogens; Concanavalin A; Cyclosporins; Diet; Diethylnitrosamine; Glutathione Transferas | 1991 |
Antigenic relationship between oval cells and a subpopulation of hepatic foci, nodules, and carcinomas induced by the "resistant hepatocyte" model system.
Topics: Animals; Antibodies, Monoclonal; Antigens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dise | 1991 |
Increased synthesis of N1-acetylspermidine in hepatic preneoplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Diethylnitrosamine; Hepatectomy; Liver; Liver Ne | 1991 |
Incidence of mutations at codon 61 of the Ha-ras gene in liver tumors of mice genetically susceptible and resistant to hepatocarcinogenesis.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Female; Genes, ras; Liver Neoplasms, Experimental | 1991 |
Diethylnitrosamine-induced metastasizing hepatocellular carcinomas in New Zealand white rabbits. A tumor model for clinical investigations.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers, Tumor; Blood Proteins; Creat | 1991 |
Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model.
Topics: Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Disease Models, Animal; Germanium; Indole | 1991 |
Effects of alpha-tocopherol, phenobarbital, and butylated hydroxyanisole during promotion of diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Analysis of Variance; Animals; Body Weight; Butylated Hydroxyanisole; Diethylnitrosamine; Eating; Li | 1991 |
Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-beta 1 expression.
Topics: Animals; Binding, Competitive; Cell Transformation, Neoplastic; Diethylnitrosamine; Epidermal Growth | 1991 |
Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1991 |
Strain specific sensitivity to diethylnitrosamine-induced carcinogenesis is maintained in hepatocytes of C3H/HeN in equilibrium with C57BL/6N chimeric mice.
Topics: Animals; Cells, Cultured; Chimera; Diethylnitrosamine; Karyotyping; Liver; Liver Neoplasms, Experime | 1991 |
The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Liver Neoplasms, Exper | 1991 |
Expression of p53 mutant protein(s) in diethylnitrosamine-induced foci of enzyme-altered hepatocytes in male Fischer-344 rats.
Topics: Animals; Diethylnitrosamine; Genes, p53; Glutathione Transferase; Immunoblotting; Immunohistochemist | 1991 |
Induction of DNA damage by N-nitrosodiethylamine in rat hepatoma cells: correlation with cytochrome P450-mediated aldrin epoxidase activity.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; | 1991 |
Free radicals generated in ethanol metabolism may be responsible for tumor promoting effects of ethanol.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasm | 1991 |
Tumor promoting potential in male F344 rats and mutagenicity in Salmonella typhimurium of dipyrone.
Topics: Animals; Body Weight; Diethylnitrosamine; Dipyrone; Dose-Response Relationship, Drug; Drinking; Kidn | 1991 |
Electron microscopic study of the peritoneal macrophages of rats with chronic fascioliasis and the carcinogenic effect of diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Fascioliasis; Liver Neoplasms, Experimental; Macrophages; Male; Periton | 1990 |
Mutational activation of H-ras and K-ras genes is absent in N-nitroso-N-methylurea-induced liver tumors in rats.
Topics: Animals; Diethylnitrosamine; Genes, ras; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mut | 1990 |
Possible involvement of poly ADP-ribosylation in phenobarbital promotion of rat hepatocarcinogenesis.
Topics: Animals; Benzamides; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasm | 1990 |
[Expression of cellular oncogenes during hepatocarcinogenesis in rats].
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Gene Expression Regulation, Neoplas | 1990 |
Enhancement of murine hepatocarcinogenesis by all-trans-retinoic acid and two synthetic retinamides.
Topics: Animals; Antineoplastic Agents; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; F | 1990 |
Immunohistochemical detection of c-myc and c-erbA products in diethylnitrosamine-induced preneoplastic and neoplastic liver lesions in rats.
Topics: Animals; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Precancerous Conditions; Proto-O | 1990 |
[The role of the components of the cyclic nucleotide system in N-nitrosodiethylamine-induced hepatic carcinogenesis in rats].
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Animals | 1990 |
High sensitivity of the LEC rat liver to the carcinogenic effect of diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Environmental Pollutants; Female; Glutathione Tr | 1990 |
Modulation by indomethacin of diethylnitrosamine-induced early changes in c-myc and c-ras expression and late incidence of preneoplastic lesions in rat liver.
Topics: Animals; Diethylnitrosamine; Female; Gene Expression; Genes, ras; Indomethacin; Liver Neoplasms, Exp | 1990 |
Ultrastructural features of diethylnitrosamine-induced lesions in the mouse liver.
Topics: Animals; Cell Membrane; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred | 1990 |
Phenobarbital enhances the formation of reactive oxygen in neoplastic rat liver nodules.
Topics: Acridines; Animals; Cytochrome P-450 Enzyme System; Diagnostic Imaging; Diethylnitrosamine; Female; | 1990 |
Is 8-hydroxydeoxyguanosine a mediator of carcinogenesis by a choline-devoid diet in the rat liver?
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Deoxyguanosine; Diethylnitrosamine; DNA; D | 1990 |
Peroxisome proliferation and modulation of rat liver carcinogenesis by 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, perfluorooctanoic acid and nafenopin.
Topics: 2-Acetylaminofluorene; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; C | 1990 |
[Changes in the epidermal growth factor receptors in the liver cells of rats in N-nitrosodiethylamine-induced hepatic carcinogenesis].
Topics: Animals; Cell Membrane; Diethylnitrosamine; Down-Regulation; Epidermal Growth Factor; ErbB Receptors | 1990 |
Influence of ginseng upon the development of liver cancer induced by diethylnitrosamine in rats.
Topics: Animals; Diethylnitrosamine; Female; Histocytochemistry; Liver; Liver Neoplasms, Experimental; Male; | 1990 |
[Changes in the contents of epidermal growth factor and EGF-like polypeptides in the liver tissue of rats in N-nitrosodiethylamine-induced hepatocarcinogenesis].
Topics: Animals; Chromatography, Gel; Diethylnitrosamine; Epidermal Growth Factor; Liver; Liver Neoplasms, E | 1990 |
[The stimulation of DNA synthesis in resting Swiss 3T3 cells by non-histone chromosomal proteins].
Topics: Animals; Cell Line; Cells, Cultured; Chromosomal Proteins, Non-Histone; Diethylnitrosamine; DNA; Kid | 1990 |
Use of magnetite particles as a contrast agent for MR imaging of the liver.
Topics: Animals; Contrast Media; Diethylnitrosamine; Female; Ferrosoferric Oxide; Image Enhancement; Iron; L | 1990 |
Studies on the effect of dietary orotic acid on mouse liver carcinogenesis induced by diethylnitrosamine.
Topics: Animals; Diet; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BA | 1990 |
The effect of choline and methionine deficiencies on the number and volume percentage of altered hepatic foci in the presence or absence of diethylnitrosamine initiation in rat liver.
Topics: Animals; Body Weight; Choline Deficiency; Diethylnitrosamine; DNA Damage; Liver; Liver Neoplasms, Ex | 1990 |
Enhancing effect of oxymetholone, an anabolic steroid, on development of liver cell foci in rats initiated with N-diethylnitrosamine.
Topics: Animals; Atrophy; Carcinogens; Diethylnitrosamine; Hyperplasia; Leydig Cells; Liver Neoplasms, Exper | 1990 |
The androgen receptor and liver tumor development in mice.
Topics: Androgen-Insensitivity Syndrome; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Hyperplasia; | 1990 |
Gap-junctional intercellular communication and murine hepatic carcinogenesis.
Topics: Animals; Cell Communication; Cells, Cultured; Culture Media; Diethylnitrosamine; Intercellular Junct | 1990 |
Liver tumor promoting ability of corn oil gavage in B6C3F1 male mice.
Topics: Animals; Carcinogens; Corn Oil; Diethylnitrosamine; Intubation, Gastrointestinal; Liver Neoplasms, E | 1990 |
Correlation between medium-term liver bioassay system data and results of long-term testing in rats.
Topics: Animals; Butylated Hydroxyanisole; Butylhydroxybutylnitrosamine; Carcinogenicity Tests; Carcinogens; | 1990 |
Lack of hepatocarcinogenic potential of acetaminophen in rats with liver damage associated with a choline-devoid diet.
Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Choline Deficiency; Diethylnitrosamine; Female; Gl | 1990 |
[Changes in cell membrane proteins during N-nitrosodiethylamine induced carcinogenesis].
Topics: Animals; Catalase; Cell Membrane; Diethylamines; Diethylnitrosamine; Endoplasmic Reticulum; Liver; L | 1990 |
The immunohistochemistry and in situ cDNA-mRNA hybridization of carbamyl phosphate synthetase I in enzyme-altered liver cells during carcinogenesis.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Diethylnitrosamine; Immunohistochemistry; Liver; Li | 1990 |
Effects of hepatocarcinogenic initiators on aldehyde dehydrogenase gene expression in cultured rat hepatic cells.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Animals; Diethylnitrosamine; Enzyme Induction; Ethion | 1990 |
Loss of sexual differentiation of metabolism of steroids and xenobiotics in nodular hepatic tissue from male and female Wistar rats treated according to the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; | 1990 |
Hepatocellular cancer development in spleen of syngenic rats after transfer of potential precursor hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Glutathione Transferase; Hepatect | 1990 |
[Expression of hetero-organic antigens--nonhistone chromosomal proteins of renal nature in liver cells of rats after administration of tetramethylthiuram disulfide and N-nitrosodiethylamine].
Topics: Animals; Antigens; Chromosomal Proteins, Non-Histone; Diethylnitrosamine; Kidney; Liver; Liver Neopl | 1990 |
[An immunohistochemical and in situ hybridization study of carbamyl phosphate synthetase I in altered liver cells during carcinogenesis].
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Diethylnitrosamine; Female; Gene Expression; Immuno | 1990 |
The inhibition by methionine and choline of liver carcinoma formation in male C3H mice dosed with diethylnitrosamine and fed phenobarbital.
Topics: Animals; Choline; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Methionine; Mice; | 1990 |
Inhibitory effect of sinigrin and indole-3-carbinol on diethylnitrosamine-induced hepatocarcinogenesis in male ACI/N rats.
Topics: Animals; Diethylnitrosamine; DNA; Glucosinolates; Indoles; Liver Neoplasms, Experimental; Male; Prec | 1990 |
Expression of rat microsomal epoxide hydrolase gene during liver chemical carcinogenesis.
Topics: Animals; Base Sequence; Diethylnitrosamine; DNA, Neoplasm; Epoxide Hydrolases; Gene Expression Regul | 1990 |
Changes in poly (A) + RNA translational pattern during chemically induced hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Neopl | 1985 |
Histochemical changes in livers from portacaval-shunted rats.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Eosine Yellowish-(YS); gamma-Glutamyltransferase; Glu | 1986 |
Progression of tumor histiotype during mouse hepatocarcinogenesis associated with the viable yellow (Avy) gene.
Topics: alpha-Fetoproteins; Animals; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Mic | 1986 |
Morphologic and cytochemical properties of mouse liver neoplasms induced by diethylnitrosamine and promoted by 4,4'-dichlorodiphenyltrichloroethane, chlordane, or heptachlor.
Topics: Animals; Carcinogens; Chlordan; DDT; Diethylnitrosamine; Heptachlor Epoxide; Insecticides; Liver Neo | 1985 |
First experiments with locoregional chemotherapy in the treatment of autochthonous rat hepatoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Diethylnitrosamine; Femal | 1988 |
Elderberry bark lectin--gold techniques for the detection of Neu5Ac (alpha 2,6) Gal/GalNAc sequences: applications and limitations.
Topics: Acetylgalactosamine; alpha-Fetoproteins; Animals; Cattle; Diethylnitrosamine; Galactosamine; Galacto | 1988 |
Adenine nucleotides and carbohydrates in subpopulations of hepatic nodules with normal and compromised microcirculation.
Topics: Adenine Nucleotides; Animals; Carbohydrate Metabolism; Dextrans; Diethylnitrosamine; Fluorescein-5-i | 1989 |
Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence.
Topics: Animals; Chlordecone; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Hepatectomy; Insecticid | 1989 |
Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio.
Topics: Animals; Diethylnitrosamine; Genes, ras; Homocysteine; Immunoblotting; Liver; Liver Neoplasms, Exper | 1989 |
Promotion of malignant 'embryonal' liver tumors by phenobarbital: increased incidence and shortened latency of hepatoblastomas in (DBA/2 x C57BL/6)F1 mice initiated with N-nitrosodiethylamine.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Crosses, Genetic; Diethylnitrosamine; Female; Hemang | 1989 |
Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Diethylnitrosamine; Enzy | 1989 |
Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Diethylnitrosamine; gamm | 1989 |
Altered expression of acute-phase reactants in mouse liver tumors.
Topics: Acute-Phase Proteins; Animals; Blotting, Northern; Diethylnitrosamine; DNA; DNA Probes; DNA, Neoplas | 1989 |
Effects of growth hormone on the expression of c-myc and c-fos during early stages of sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Actins; Animals; Blotting, Northern; Diethylnitrosamine; Female; Gene Express | 1989 |
Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Diethylnitrosamine; Drug Sy | 1989 |
Expression of the c-myc, c-fos and c-rasHa protooncogenes during sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model.
Topics: Animals; Diethylnitrosamine; Female; Genes, ras; Liver; Liver Neoplasms, Experimental; Male; Models, | 1989 |
Expression of oncogenes during rat chemical hepatotumorigenesis promoted by estrogen.
Topics: Animals; Diethylnitrosamine; Diethylstilbestrol; DNA Probes; Gene Expression Regulation, Neoplastic; | 1989 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine | 1989 |
Expression of N-acetylglucosaminyltransferase III in hepatic nodules generated by different models of rat liver carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Glucosyltransferases; Intracellular Me | 1989 |
Investigation of tumor initiating and/or cocarcinogenic properties of arsenite and arsenate with the rat liver foci bioassay.
Topics: Adenosine Triphosphatases; Animals; Arsenates; Arsenic; Arsenites; Diethylnitrosamine; Female; Liver | 1989 |
Metaplastic pancreatic cells in liver tumors induced by diethylnitrosamine.
Topics: Adenoma, Bile Duct; Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlor | 1989 |
[The activity of nuclear endonucleases and topoisomerases in the liver of rats and in diethylnitrosamine-induced tumors].
Topics: Animals; Buffers; Cell Nucleus; Diethylnitrosamine; DNA Topoisomerases, Type I; Endonucleases; Liver | 1989 |
[Biological activity of hepatocellular carcinoma by analysing nuclear DNA ploidy patterns and using anti BrdU monoclonal antibody].
Topics: Aged; Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Nucleus; D | 1989 |
RNAs containing mitochondrial ND6 and COI sequences present an abnormal structure in chemically induced rat hepatomas.
Topics: Animals; Blotting, Southern; Cell Line; Cloning, Molecular; Cytochrome Reductases; Diethylnitrosamin | 1989 |
Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.
Topics: Animals; Base Sequence; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA; Female; gamma-Glutamyltrans | 1989 |
Differential susceptibility of a fish, tilapia Oreochromis mossambicus (Teleostei, Cichlidae) to hepatocarcinogenesis by diethylnitrosamine and methylazoxymethanol acetate.
Topics: Animals; Azo Compounds; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; Female; Fish Di | 1989 |
The role of GSH depletion and toxicity in hydroquinone-induced development of enzyme-altered foci.
Topics: Animals; Benzoquinones; Diethylnitrosamine; DNA Damage; gamma-Glutamyltransferase; Glutathione; Hydr | 1989 |
Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver.
Topics: Adenosine Triphosphatases; Animals; Anticholesteremic Agents; Carcinogens; Diethylnitrosamine; gamma | 1989 |
Lack of modifying effects of 2,2'-[(4-aminophenyl) imino] bisethanol sulfate on induction of preneoplastic gamma-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Eating; gamma-Glutamyltransferase; Hair | 1989 |
Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Biomarkers, Tumor; Body Weight; Diethyl | 1989 |
Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations.
Topics: 2-Acetylaminofluorene; Adenoma; Aflatoxin B1; Aflatoxins; Animals; Biomarkers, Tumor; Diethylnitrosa | 1989 |
[Early stages of hepatic carcinogenesis after vagotomy].
Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Enzyme Acti | 1989 |
Sex-steroid receptors in the diethylnitrosamine model of hepatocarcinogenesis: modifications by gonadal ablation and steroid replacement therapy.
Topics: Animals; Diethylnitrosamine; Estrogens; Female; Liver; Liver Neoplasms, Experimental; Male; Orchiect | 1989 |
Comparative study of diethylnitrosamine-initiated two-stage hepatocarcinogenesis in C3H, C57BL and BALB mice promoted by various hepatopromoters.
Topics: Animals; Clofibrate; Diethylnitrosamine; Ethinyl Estradiol; Liver; Liver Neoplasms, Experimental; Li | 1989 |
Cell population kinetics and ploidy rate of early focal lesions during hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Count; Diethylnitrosamine; DNA; Liver; Li | 1989 |
Ethanol treatment inhibits the development of diethylnitrosamine-induced tumors in rats.
Topics: Animals; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme | 1989 |
Morphometric study of chromatin pattern in freeze-fractured rat liver nuclei during malignancy evolution.
Topics: Animals; Chromatin; Diethylnitrosamine; Freeze Fracturing; Image Processing, Computer-Assisted; Live | 1989 |
Medium-term bioassay system for detection of carcinogens and modifiers of hepatocarcinogenesis utilizing the GST-P positive liver cell focus as an endpoint marker.
Topics: Animals; Biomarkers, Tumor; Carcinogenicity Tests; Diethylnitrosamine; Gene Expression Regulation, E | 1989 |
[Antigenic divergence in a primary rat hepatocyte culture after exposure to the hepatic carcinogen N-diethylnitrosamine].
Topics: Animals; Antigenic Variation; Antigens, Heterophile; Antigens, Neoplasm; Antigens, Surface; Cells, C | 1989 |
[Inhibitory effects of jian pi li qi Chinese medicinal herbs on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in rats].
Topics: Animals; Diethylnitrosamine; Drugs, Chinese Herbal; Gene Expression Regulation; Genes, ras; Liver Ne | 1989 |
Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; Female; Glutathione Transferase; Immunoenzyme | 1989 |
Expression pattern of the genes for different members of the heat-shock protein 70 family, ornithine decarboxylase, and c-Ha-ras during the early stages of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Diethylnitrosamine; Gene Expression Regulation, | 1989 |
Identification of the putative first cellular step of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Cell Division; | 1989 |
Immunocytochemical detection of the onco-developmental protein oncomodulin in pre-neoplastic and neoplastic hepatocellular lesions during hepatocarcinogenesis in rats.
Topics: Animals; Calcium-Binding Proteins; Diethylnitrosamine; Female; Hepatectomy; Immunohistochemistry; Li | 1989 |
Chromosomal analysis of a diethylnitrosamine-induced tumorigenic and a nontumorigenic rat liver cell line.
Topics: Animals; Cell Line; Chromosome Aberrations; Diethylnitrosamine; Karyotyping; Liver Neoplasms, Experi | 1989 |
Oxidative metabolism of 4-hydroxy-2,3-nonenal during diethyl-nitrosamine-induced carcinogenesis in rat liver.
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Diethylnitrosamine; Lipid Peroxides; Liver; Liver Neopla | 1989 |
Focal impairment of growth in hepatocellular neoplasms of C57BL/6 mice: a possible explanation for the strain's resistance to hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; DNA Replication; Immunity, Innate; Liver Neoplasms, Experimental; Lung | 1989 |
Hexachlorobenzene as a promoter of diethylnitrosamine-initiated hepatocarcinogenesis in rats and comparison with induction of porphyria.
Topics: Animals; Body Weight; Carcinogens; Chlorobenzenes; Diethylnitrosamine; Female; Hexachlorobenzene; Li | 1989 |
Strain differences in hepatic tumor promotion by phenobarbital in diethylnitrosamine- and dimethylnitrosamine-initiated infant male mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Drug Interactions; Liver Neoplasms, E | 1989 |
Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J mice and F344 rats.
Topics: Adenocarcinoma; Animals; Carcinogens; Diethylnitrosamine; Female; Hemangiosarcoma; Liver Neoplasms; | 1989 |
Fatty acid composition of phospholipids in mitochondria and microsomes during diethylnitrosamine carcinogenesis in rat liver.
Topics: Animals; Cardiolipins; Diethylnitrosamine; Fatty Acids; Hyperplasia; Liver Neoplasms; Liver Neoplasm | 1989 |
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
Topics: Adenoma; Aminopyrine N-Demethylase; Animals; Carcinogens; Carcinoma; Cell Communication; Clonazepam; | 1989 |
A semipurified diet that suppresses phenobarbital promotion of hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; Food, Formulated; Liver; L | 1989 |
Promotion of murine hepatocarcinogenesis by testosterone is androgen receptor-dependent but not cell autonomous.
Topics: Aging; Androgen-Insensitivity Syndrome; Animals; Diethylnitrosamine; Disease Susceptibility; Female; | 1989 |
Genetic control of susceptibility to diethylnitrosamine carcinogenesis in inbred ACP (grc+) and R16 (grc) rats.
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Major Histocompa | 1989 |
[Adrenergic mechanisms of the regulation of stages of chemical carcinogenesis: role of presynaptic receptors].
Topics: Animals; Carcinogens; Diethylnitrosamine; Levodopa; Liver Neoplasms, Experimental; Male; Rats; Recep | 1988 |
Detection of activated proto-oncogenes in N-nitrosodiethylamine-induced liver tumors: a comparison between B6C3F1 mice and Fischer 344 rats.
Topics: Animals; Cell Transformation, Neoplastic; Codon; Diethylnitrosamine; DNA Restriction Enzymes; DNA, N | 1988 |
Cell phenotype instability in preneoplastic foci of rat liver.
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Live | 1988 |
Lack of hepatic promotional activity by the peroxisomal proliferating hepatocarcinogen di(2-ethylhexyl)phthalate.
Topics: Animals; Cell Division; Clofibrate; Diethylhexyl Phthalate; Diethylnitrosamine; Female; gamma-Glutam | 1985 |
Different responses to phenobarbital promotion in the development of gamma-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetyl-aminofluorene and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyl | 1985 |
Stage dependent enhanced induction of hepatocellular carcinomas in rats administered a second dose of diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; | 1985 |
Histochemical characterization of focal hepatic lesions induced by single diethylnitrosamine treatment in infant mice.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glycogen | 1985 |
Hepatocarcinogenic and promoting action of a choline-devoid diet in the rat.
Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransf | 1985 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine.
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA; Drug Resistance; gamma-Glutamyltransferase; Hepatecto | 1985 |
Inhibitory potential of acetaminophen and o-, m-, p- aminophenols for development of gamma-glutamyltranspeptidase-positive liver cell foci in rats pretreated with diethylnitrosamine.
Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; gamma-Glutamyltransferase; Li | 1985 |
The quantitative analysis and stability of histochemical markers of altered hepatic foci in rat liver following initiation by diethylnitrosamine administration and promotion with phenobarbital.
Topics: Adenosine Triphosphatases; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltran | 1985 |
Diethylnitrosamine induced enzyme altered areas in the rat liver: effect of partial hepatectomy.
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experim | 1985 |
Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Ex | 1985 |
Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Diethylnitrosamine; Dose-Response Relationship, D | 1985 |
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kin | 1985 |
Activities of benzphetamine N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from gamma-glutamyl transpeptidase-positive foci and surrounding liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Separation; Cytochrome P-450 Enzyme System; Diethylnitr | 1985 |
Correlation of O4-ethyldeoxythymidine accumulation, hepatic initiation and hepatocellular carcinoma induction in rats continuously administered diethylnitrosamine.
Topics: Age Factors; Alkylation; Animals; Diethylnitrosamine; DNA; DNA Repair; DNA Replication; gamma-Glutam | 1986 |
Biochemical and morphologic studies of heterogeneous lobe responses in hepatocarcinogenesis.
Topics: Alkylation; Animals; Carbon Radioisotopes; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; | 1986 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats.
Topics: Analysis of Variance; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Diethylnitrosamine; Fatt | 1986 |
Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamy | 1986 |
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxym | 1986 |
Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment.
Topics: Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Diethylnitrosamine; Enzym | 1986 |
Effects of varying fat content of a high tryptophan diet on the induction of gamma-glutamyltranspeptidase positive foci in the livers of rats treated with hepatocarcinogen.
Topics: Animals; Body Weight; Diet; Dietary Fats; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy | 1986 |
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Ne | 1986 |
Influence of the nature and the dose of the initiator on the development of premalignant and malignant lesions in rat hepatocarcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver; Liver Neoplasms, | 1986 |
Enhancing effect of co-administration of polychlorinated biphenyls and diethylnitrosamine on enzyme-altered islands induced by diethylnitrosamine in rat liver.
Topics: Adenosine Triphosphatases; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltran | 1986 |
Sequential study on the synergistic effects of 2,2',4,4',5,5'-hexabromobiphenyl and 3,3',4,4',5,5'-hexabromobiphenyl on hepatic tumor promotion.
Topics: Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental | 1986 |
Dinitrotoluene isomer-specific enhancement of the expression of diethylnitrosamine-initiated hepatocyte foci.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dinitrobenzenes; Dose-Response Relationship, Drug; ga | 1986 |
Investigations on the carcinogenicity of fusarin C--a mutagenic metabolite of Fusarium moniliforme.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Fusarium; gamma-Glutamyltransferase; Liver Ne | 1986 |
[Sensitivity of rat hepatocytes to phenobarbital after a single dose of N-nitrosodiethylamine in the embryonal and postnatal period or after partial hepatectomy].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Hyper | 1987 |
Persistent effect of a low dose of preadministered diethylnitrosamine on the induction of enzyme-altered foci in rat liver.
Topics: Animals; Diethylnitrosamine; DNA Repair; gamma-Glutamyltransferase; Glutathione Transferase; Hepatec | 1987 |
Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.
Topics: Animals; Chick Embryo; Chlorophenols; Cocarcinogenesis; Diethylnitrosamine; Dioxoles; Female; gamma- | 1987 |
The clonal nature of carcinogen-induced altered foci of gamma-glutamyl transpeptidase expression in rat liver.
Topics: Animals; Chimera; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimenta | 1987 |
Effects of separate and combined treatments with gamma radiation and diethylnitrosamine in neonatal rats on the induction of altered hepatocyte foci and hepatic tumors.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; DNA Damage; Female; Gamma Rays; gamma-Glutamyltransfe | 1987 |
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma | 1987 |
Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Deoxyadenosines; Diethylnitrosamine; DNA; gamma-Glutamylt | 1987 |
Complementarity between two rat liver tumor promoters.
Topics: Animals; Choline Deficiency; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neopl | 1987 |
Dose-response of promotion by polychlorinated biphenyls and chloroform in rat liver foci bioassay.
Topics: Adenosine Triphosphatases; Animals; Chloroform; Diethylnitrosamine; Female; gamma-Glutamyltransferas | 1987 |
Liver cell proliferation induced by the mitogen ethylene dibromide, unlike compensatory cell proliferation, does not achieve initiation of rat liver carcinogenesis by diethylnitrosamine.
Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Ethylene Dibromide; gamma-Glutamyl | 1987 |
Effect of vitamin E on the induction and evolution of enzyme-altered foci in the liver of rats treated with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Transferase; Hematoxylin; Hyperp | 1987 |
Molecular dosimetry of DNA alkylation during chronic exposure to carcinogens.
Topics: Alkylation; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA; Dose-Res | 1987 |
Hepatocyte initiation during continuous administration of diethylnitrosamine and 1,2-sym-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Diethylnitrosamine; Dimethylhydrazines; | 1988 |
2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; L | 1988 |
Expression of the cytosolic and particulate forms of transglutaminase during chemically induced rat liver carcinogenesis.
Topics: Animals; Carcinoma; Cell Transformation, Neoplastic; Cell-Free System; Cytosol; Diethylnitrosamine; | 1988 |
Cancer promoting potential of different strains of Fusarium moniliforme in a short-term cancer initiation/promotion assay.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Ducks; Fusarium; gamma-Glutamyltransfera | 1988 |
Fumonisins--novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme.
Topics: Animals; Body Weight; Carcinogens, Environmental; Chromatography; Diethylnitrosamine; Fumonisins; Fu | 1988 |
The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamylt | 1988 |
Chronic liver injury by thioacetamide and promotion of hepatic carcinogenesis.
Topics: Acetamides; Animals; Carcinogens; Diethylnitrosamine; Liver; Liver Cirrhosis, Experimental; Liver Ne | 1989 |
The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Air Pollutants; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug | 1989 |
Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender.
Topics: Animals; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; | 1989 |
Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Diploidy; DNA, Neoplasm; Liver Neoplasms, Experi | 1989 |
[A preliminary study on the development of altered cells in different liver cell subpopulations of diethylnitrosamine-treated rats].
Topics: Animals; Diethylnitrosamine; Diethylstilbestrol; Female; Liver; Liver Neoplasms, Experimental; Male; | 1986 |
[Studies on the mechanism of carcinogenesis. VIII. Purification of ornithine carbamyl transferase in the rat liver and immunochemical titration of the enzyme during carcinogenesis].
Topics: Animals; Diethylnitrosamine; Histocytochemistry; Immune Sera; Immunoenzyme Techniques; Liver Neoplas | 1986 |
[Increase in a protein of Mr 53000 in the initiation-promotion system of chemical carcinogenesis in rat liver].
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Neoplasm Proteins; Phosphop | 1986 |
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neo | 1987 |
Membrane enzyme cytochemical changes in the hepatocytes of diethylnitrosamine induced hepatomas.
Topics: Adenosine Triphosphatases; Animals; Cell Membrane; Diethylnitrosamine; Endoplasmic Reticulum; Glucos | 1985 |
Histochemistry of liver tumors induced by diethylnitrosamine and differential sex susceptibility to carcinogenesis in Oryzias latipes.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; Fishes; Glucose-6-Phosphatase; Histo | 1985 |
Vascular sarcomas (probably angiosarcomas) transplanted from suspensions of liver cells from diethylnitrosamine-treated rats.
Topics: Alkaline Phosphatase; Animals; Cell Separation; Diethylnitrosamine; Endothelium; Factor VIII; Hemang | 1985 |
Binding of growth hormone to rat liver during experimental chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Golgi Apparatus; Growth Hormone; Liver; Liver Ne | 1986 |
Effects of diethylnitrosamine on hepatic receptor binding and autophosphorylation of epidermal growth factor and insulin in rats.
Topics: Animals; Cell Membrane; Diethylnitrosamine; Dose-Response Relationship, Drug; Electrophoresis, Polya | 1986 |
Binding of epidermal growth factor and insulin and the autophosphorylation of their receptors in experimental primary hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Epidermal Growth Factor; ErbB Receptors; Golgi A | 1986 |
Presence of albumin-positive cells in the liver of analbuminemic rats and their increase on treatment with hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Diethylnitrosamine; Hepatectomy; Liver; Liver Neoplasms | 1986 |
Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aniline Compounds; Animals; Body Weight; Butylated Hydroxyanis | 1986 |
Resistance to oxidative stress by hyperplastic and neoplastic rat liver tissue monitored in terms of production of unpolar and medium polar carbonyls.
Topics: Aldehydes; Animals; Arachidonic Acid; Arachidonic Acids; Cell Transformation, Neoplastic; Chromatogr | 1986 |
Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats.
Topics: Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Fem | 1986 |
Possible model of liver carcinogenesis using inhibitors of NAD+ ADP ribosyl transferase in rats.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Male; NAD; Phenobarbita | 1986 |
Modifying effects of butylated hydroxyanisole, di(2-ethylhexyl)phthalate or indomethacin on mouse hepatocarcinogenesis initiated by N-nitrosodiethylamine.
Topics: Adenoma; Animals; Butylated Hydroxyanisole; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosa | 1986 |
[Polyamine levels and diamine oxidase activity in the rat liver and kidneys during hepatocarcinogenesis induced by N-nitrosodiethylamine].
Topics: Amine Oxidase (Copper-Containing); Animals; Diethylamines; Diethylnitrosamine; Kidney; Liver; Liver | 1987 |
Histology and histochemistry of the liver of chickens after DENA induced hepatocarcinogenesis and ingestion of low chlorinated biphenyls.
Topics: Animals; Chickens; Diethylnitrosamine; Female; Histocytochemistry; Liver; Liver Neoplasms, Experimen | 1987 |
Long-term dosing studies using mutagenic carcinogens indicate a highly significant correlation between elevations in the level of rat glutathione S-transferase P messenger RNA and liver tumours of hepatocellular origin.
Topics: Animals; Benzothiazoles; Carcinogens; Diethylnitrosamine; Electrophoresis, Agar Gel; Glutathione Tra | 1988 |
Lack of initiating and promoting activity of thiourea in rat liver foci bioassay.
Topics: Animals; Biological Assay; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Precance | 1988 |
Diethyl-nitrosamine hepatocarcinogenesis in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver Cirrhosis, Experimental; Liver Neoplasms, E | 1987 |
Preventive effect of 3-aminobenzamide on the reduction of NAD levels in rat liver following administration of diethylnitrosamine.
Topics: Animals; Benzamides; Diethylnitrosamine; DNA Repair; Liver; Liver Neoplasms, Experimental; Male; NAD | 1988 |
Inhibitory effect of tamoxifen on diethylstilbestrol-promoted hepatic tumorigenesis in male rats and its possible mechanism of action.
Topics: Animals; Diethylnitrosamine; Diethylstilbestrol; Liver Neoplasms, Experimental; Male; Precancerous C | 1988 |
Partial hepatectomy of rats ten weeks before carcinogen administration can enhance liver carcinogenesis: preliminary observations.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Liver Neoplasms, Experimental; Male; Rat | 1988 |
Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion.
Topics: Adenoma; Animals; Animals, Newborn; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship | 1988 |
Effects of potassium ethylxanthogenate on nitrosodiethylamine-induced DNA damage and on liver carcinogenesis.
Topics: Animals; Diethylnitrosamine; DNA Damage; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Str | 1988 |
Chlorobenzilate-induced effects on enzyme-altered foci in rat liver and intercellular communication in rat liver WB-F344 epithelial cells.
Topics: Animals; Benzilates; Cell Communication; Cell Line; Cocarcinogenesis; Cricetinae; Diethylnitrosamine | 1988 |
[The effect of subcutaneous nitrosamine injections on the origin of tumors of the liver and their inhibition by vitamin C].
Topics: Animals; Ascorbic Acid; Diethylnitrosamine; Female; Injections, Subcutaneous; Liver Neoplasms, Exper | 1988 |
A comparison of the carcinogenicity of N-nitrosodiethylamine and N-nitrosodimethylamine after intratracheal instillation into Syrian golden hamsters.
Topics: Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Liver Neoplasms, Experimental; Lung Ne | 1988 |
Hypolipidemic drug clofibrate promotes hepatic tumor.
Topics: Animals; Carcinogenicity Tests; Clofibrate; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; | 1988 |
[The effect of "SRRS" recipe on the formation of liver cancer in the rat].
Topics: Animals; Diethylnitrosamine; Drugs, Chinese Herbal; Liver; Liver Neoplasms, Experimental; Male; Rats | 1988 |
Lack of a relationship between immune function and chemically induced hepatocarcinogenesis in B6C3F1 mice.
Topics: Animals; Diethylnitrosamine; Female; Hematopoiesis; Killer Cells, Natural; Liver Neoplasms, Experime | 1988 |
[Effect of sialadenectomy on hepatic carcinogenesis in rats induced by N-nitrosodiethylamine].
Topics: Animals; Diethylnitrosamine; Epidermal Growth Factor; Liver; Liver Neoplasms, Experimental; Male; Ra | 1988 |
[Molecular weights of the hetero-organic NHCP antigens of kidney origin associated with rat hepatomas].
Topics: Animals; Antigens, Heterophile; Antigens, Neoplasm; Chromatography, Gel; Chromatography, Ion Exchang | 1988 |
Immunohistochemical detection of c-Ha-ras oncogene p21 product in pre-neoplastic and neoplastic lesions during hepatocarcinogenesis in rats.
Topics: Animals; Diethylnitrosamine; DNA Replication; Female; Genes, ras; Immunohistochemistry; Liver Neopla | 1988 |
Reactivity of monoclonal antibodies to oncoproteins with normal rat liver, carcinogen-induced tumours, and premalignant liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Diethylnitrosamine; Immunoenzyme Techniques; | 1988 |
Ploidy distribution in experimental liver carcinogenesis in mice.
Topics: Animals; Diethylnitrosamine; DNA; Flow Cytometry; Liver Neoplasms, Experimental; Liver Regeneration; | 1988 |
Reciprocal relationship between development of glutathione S-transferase positive liver foci and proliferation of surrounding hepatocytes in rats.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxyanisole; Cell Division; Diethylnitrosamine; Glutath | 1988 |
Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats--an approach for a new medium-term bioassay system.
Topics: Animals; Biological Assay; Diethylnitrosamine; Enzyme Induction; Glutathione Transferase; Liver Neop | 1988 |
[Content of cytochrome P-450 and its induction capacity in primary liver tumors in rats].
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Diethylnitrosamine | 1988 |
Increased hepatic androgen receptor expression in female rats during diethylnitrosamine liver carcinogenesis. A possible correlation with liver tumor development.
Topics: Animals; Binding, Competitive; Cell Transformation, Neoplastic; Diethylnitrosamine; Female; Isoelect | 1988 |
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
Topics: Animals; Barbital; Barbiturates; Body Weight; Cytochrome P-450 Enzyme System; Diethylnitrosamine; En | 1988 |
Dose-time relationship of the development of preneoplastic liver lesions induced in rats with low doses of N-nitrosodiethanolamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Kinetics; Liver; Liver N | 1988 |
The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Diploidy; DNA; DNA, Neoplasm; Flo | 1988 |
Characterization of tumor specific antigens on the plasma membrane surface of rat hepatomas induced by 3'-Me DAB and identification of the common tumor specific antigens from rat hepatomas induced by different chemical hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Antigens, Surface; Diethylnitrosamine; Liver Neo | 1988 |
Cloning of cDNA coding for carbamyl phosphate synthetase I and changes in levels of CPS1 mRNA during hepatocarcinogenesis.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cloning, Molecular; Diethylnitrosamine; DNA; Ligase | 1988 |
Shift from polyploidizing to nonpolyploidizing growth in carcinogen-treated rat liver.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Flow Cytometry; Liver; Liver Neoplasms, Experime | 1988 |
[Effect of preparations of unsaturated fatty acids on the lipid component of the endoplasmic reticulum membranes of liver cells in rats following administration of N-nitrosodiethylamine].
Topics: Animals; Diethylnitrosamine; Endoplasmic Reticulum; Fatty Acids, Unsaturated; Intracellular Membrane | 1988 |
Studies on the mechanism of the carcinogenetic activity of thioacetamide on rat liver.
Topics: Acetamides; Animals; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Rats; Rats, In | 1988 |
Studies on the mechanism of carcinogenesis (IX)--Differential expression of proliferating and tissue-specific enzyme genes during hepatocarcinogenesis.
Topics: Animals; Aspartate Carbamoyltransferase; Diethylnitrosamine; DNA; Liver; Liver Neoplasms, Experiment | 1988 |
Tyrosine protein kinase in preneoplastic and neoplastic rat liver.
Topics: Affinity Labels; Animals; Antibodies; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Methy | 1988 |
[The use of a primary culture of liver cells from rat embryos subjected to transplacental exposure to N-nitrosodiethylamine for the study of hepatocarcinogenesis promoters].
Topics: Animals; Carcinogens; Cells, Cultured; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Ne | 1987 |
Effect of phenobarbital on the development of liver tumors in juvenile and adult mice.
Topics: Adenoma; Age Factors; Animals; Carcinoma; Diethylnitrosamine; DNA; Liver Neoplasms, Experimental; Ma | 1986 |
Comparison of lesions induced in the Syrian golden hamster by diethylnitrosamine, dimethylhydrazine, and dibutylnitrosamine: influence of subsequent butylated hydroxyanisole treatment.
Topics: Animals; Butylated Hydroxyanisole; Cricetinae; Diethylnitrosamine; Dimethylhydrazines; Glutathione T | 1987 |
The histopathology and biochemistry of phenobarbitone-induced liver nodules in C3H mice.
Topics: Animals; Diethylnitrosamine; Histocytochemistry; Liver; Liver Neoplasms, Experimental; Male; Mice; M | 1987 |
Coordinate polypeptide expression during hepatocarcinogenesis in male F-344 rats: comparison of the Solt-Farber and Reddy models.
Topics: Animals; Clofibric Acid; Computers; Cytosol; Diethylnitrosamine; Dihydrolipoamide Dehydrogenase; Dis | 1987 |
HMP-shunt and cholesterol metabolism in experimental models involving normal and preneoplastic liver growth.
Topics: Animals; Cell Division; Cholesterol; Diabetes Mellitus, Experimental; Diethylnitrosamine; Fasting; G | 1987 |
Induction of a novel Ca2+-dependent serine protease in rat liver treated with various promoters of liver carcinogenesis.
Topics: Animals; Calcium; Carcinogens; Diethylnitrosamine; Endopeptidases; Enzyme Induction; Liver Neoplasms | 1987 |
Expression of retroviral sequences and oncogenes in rat liver tumors induced by diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; ErbB Receptors; Female; Gene Expression Regulation; Genes, Viral; Liver | 1987 |
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver | 1987 |
Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions.
Topics: Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Epoxide Hydrolases; Glutathione Transfe | 1987 |
Genetic susceptibility to murine hepatocarcinogenesis is associated with high growth rate of NDEA-initiated hepatocytes.
Topics: Adenoma; Animals; Carcinoma; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Mice; | 1987 |
Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylhexyl Phthalate | 1987 |
[Ethinyl estradiol and hepatocarcinogenesis. An experimental study].
Topics: Animals; Diethylnitrosamine; Drug Synergism; Ethinyl Estradiol; Female; Liver; Liver Neoplasms, Expe | 1987 |
Changes in aldehyde dehydrogenase activity during diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Aldehyde Dehydrogenase; Animals; Diethylnitrosamine; Female; Histocytochemistry; Kinetics; Liver; Li | 1987 |
Certain aspects of hepatocarcinogenesis in the infant mouse model.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Female; Liver; Liver Neoplasms; Liver Neoplasms | 1987 |
Two-stage liver carcinogenesis in the mouse.
Topics: Animals; Diethylnitrosamine; Disease Susceptibility; Female; Liver; Liver Neoplasms, Experimental; M | 1987 |
Effects of an initiation-promotion-initiation protocol on the liver carcinogenesis in the one day old rat.
Topics: Amides; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Female; Liver Neoplasms, Exper | 1987 |
[The initiation-promotion-initiation protocol in experimental liver carcinogenesis].
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Rats; Rats, In | 1987 |
Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; Glutathione Transferase; Kidn | 1987 |
Enhancement of DEN-induced hepatocellular nodule development by Opisthorchis viverrini infection in Syrian golden hamsters.
Topics: Animals; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; Liver Neoplasms, Experimental; Mesocricet | 1987 |
[Promotive effect of estrogen on hepatocarcinogenesis in rats: the effect of tamoxifen and changes in estrogen receptors].
Topics: Animals; Diethylnitrosamine; Diethylstilbestrol; Estrogen Antagonists; Liver Neoplasms, Experimental | 1987 |
Time course of dolichol and dolichyl phosphate during chemical carcinogenesis in rat liver.
Topics: Acyl Coenzyme A; Animals; Diethylnitrosamine; Diterpenes; Dolichol Phosphates; Dolichols; Hepatectom | 1987 |
Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug C | 1987 |
[Effect of subtotal hepatectomy in rats on the induction of cirrhosis of liver and hepatocellular carcinoma by diethylnitrosamine].
Topics: Animals; Diethylnitrosamine; Female; Hepatectomy; Liver Cirrhosis, Experimental; Liver Neoplasms, Ex | 1987 |
Syncarcinogenesis at low exposure levels of three nitrosamines with a common target of carcinogenic action: preliminary results.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; N-Nitrosopyrroli | 1987 |
Invasiveness, proliferative activity and ultrastructural phenotypes of hepatocytes from diethylnitrosamine-induced neoplastic nodules and hepacarcinomas in vitro.
Topics: Animals; Autoradiography; Cell Division; Chick Embryo; Diethylnitrosamine; In Vitro Techniques; Live | 1987 |
Effects of calcium glucarate on the promotion of diethylnitrosamine-initiated altered hepatic foci in rats.
Topics: Animals; Calcium; Diet; Diethylnitrosamine; Female; Glucaric Acid; Glucuronidase; Liver Neoplasms, E | 1987 |
[Characteristics of hepatocarcinogenesis after single exposure of synchronized cells of the regenerating liver to N-nitrosodiethylamine and subsequent administration of phenobarbital].
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Liver Regenerat | 1987 |
Enhancing effects of carbon tetrachloride in mouse hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Neoplasms, | 1986 |
Aldehyde dehydrogenase as a marker for chemically initiated mouse liver tumors.
Topics: Aldehyde Dehydrogenase; Animals; Clinical Enzyme Tests; Diethylnitrosamine; Enzyme Induction; Histoc | 1986 |
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cocarcinogenesis; Cytochrome P-450 Enzyme System; D | 1986 |
Liver lesions in BALB/C mice induced by an anabolic androgen (Decadurabolin), with and without pretreatment with diethylnitrosamine.
Topics: Anabolic Agents; Animals; Body Weight; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Mal | 1986 |
Pituitary grafts modify sex differences in liver tumor formation in the rat following initiation with diethylnitrosamine and different promotion regimens.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Disease Models, Animal; Female; Hydroxyacetylami | 1986 |
Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Diethylh | 1986 |
Induction of heat shock gene expression without heat shock by hepatocarcinogens and during hepatic regeneration in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Heat-Shock Proteins; Liver; Liver N | 1986 |
Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice.
Topics: Alleles; Animals; Body Weight; Crosses, Genetic; Diethylnitrosamine; DNA; Female; Liver Neoplasms, E | 1986 |
Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms, Ex | 1986 |
Anti-carcinogenic action of phenobarbital given simultaneously with diethylnitrosamine in the rat.
Topics: Animals; Diethylnitrosamine; Drug Interactions; Liver Neoplasms, Experimental; Male; Mitotic Index; | 1986 |
Changes in cellular ploidy and autophagic responsiveness during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Autophagy; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; | 1986 |
Characterization of the promoting activity of thiobenzamide on liver carcinogenesis.
Topics: Amides; Animals; Carcinogens; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Male | 1986 |
Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters.
Topics: Aminopyrine N-Demethylase; Animals; Carcinogens; Cricetinae; Cytochrome P-450 Enzyme System; Diethyl | 1986 |
Enhancing effect of 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran on diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Benzofurans; Body Weight; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Polymers | 1986 |
Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Drug Interactio | 1987 |
Changes in nucleolar transcriptional activity and nuclear DNA content during the first steps of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Cell Nucleolus; Diethylnitrosamine; | 1987 |
Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis.
Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Hepatectomy; Lead; Liver Neoplasms | 1987 |
New data on kinetics of lipid peroxidation in experimental hepatomas and preneoplastic nodules.
Topics: Alcohol Dehydrogenase; Animals; Chromatography, High Pressure Liquid; Diethylnitrosamine; Glutathion | 1986 |
Effect of phenobarbital on the content of RNA polymerase B regulatory factors during diethylnitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Neoplasm Proteins; Phenobarbital; | 1985 |
Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine.
Topics: Amobarbital; Animals; Barbital; Barbiturates; Body Weight; Diethylnitrosamine; Liver Neoplasms, Expe | 1985 |
[Immunosuppressive effect and promotor activity for hepatic carcinogenesis of thiobenzamide].
Topics: Amides; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Female; Hemolytic Plaque Techniq | 1985 |
[Detection of the common features in the antigenic structure and the spectra of the phosphoprotein kinase activity proper of the water-soluble fractions of DNA-free nuclear nonhistone proteins from hepatomas and the liver in rats following a single admini
Topics: Animals; Antigens; Antigens, Neoplasm; Chromosomal Proteins, Non-Histone; Diethylnitrosamine; DNA; D | 1985 |
An approach to the development of a short-term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biological Assay; Butylated Hydroxyanisole; Carcinogens; | 1985 |
Sequential analysis of chemically induced hepatoma development in rats by two dimensional electrophoresis.
Topics: Albumins; Aldehyde Dehydrogenase; Animals; Cytosol; Diethylnitrosamine; Electrophoresis, Polyacrylam | 1986 |
Changes in progesterone binding and metabolism in liver microsomes from persistent hepatocyte nodules and hepatomas in male rats.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Intracellular Me | 1986 |
Evidence for growth heterogeneity among foci with different phenotypes in the population of altered hepatocyte foci induced by a single neonatal treatment with carcinogen.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Phenotype; | 1986 |
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mic | 1986 |
Dehydrogenase histochemistry of N-ethyl-N-hydroxyethylnitrosamine-induced focal liver lesions in the rat--increase in NADPH-generating capacity.
Topics: Animals; Diethylnitrosamine; Fatty Acids; Histocytochemistry; Liver Neoplasms, Experimental; Male; N | 1986 |
Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; E | 1986 |
Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; L | 1985 |
Kinetics of diethylnitrosamine hepatocarcinogenesis in the infant mouse.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; Kinetics; Liver Neoplasms, Experimental; Mice; Nitros | 1985 |
Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis.
Topics: Adenoma; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; | 1985 |
Influence of a prolonged treatment with disulfiram and D(-)penicillamine on nitrosodiethylamine-induced biological and biochemical effects in rats. I. Investigations on the drug metabolizing system.
Topics: Animals; Diethylnitrosamine; Disulfiram; Drug Interactions; Enzyme Inhibitors; Esophageal Neoplasms; | 1985 |
Effect of phenobarbital on the activity of RNA polymerase II during diethylnitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Nitrosamines; Phenobarbital; Rats; | 1985 |
Alterations in nonhistone chromatin proteins during hepatocarcinogenesis induced by diverse acting carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Cell Cycle; Chromatin; Chromosomal Proteins, Non-Histone; Diethylnit | 1985 |
Kinetics of formation and persistence of ethylguanines in DNA of rats and hamsters treated with diethylnitrosamine.
Topics: Alkylation; Animals; Cricetinae; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; | 1985 |
Differential repair of O4-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Diethylnitrosamine; Dimethylhydrazines; DNA, Neoplasm; | 1985 |
Microcirculation of hepatic nodules from diethylnitrosamine-treated rats.
Topics: Animals; Diethylnitrosamine; Fluorescence; Liver; Liver Circulation; Liver Neoplasms, Experimental; | 1985 |
Liver tyrosine kinase activation during early stages of chemical hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; Enzyme Activation; Liver; Liver Neoplasms, Experimental; Male; Protein | 1985 |
Promotion of preneoplastic changes in liver by coal-derived organic mixtures applied to skin.
Topics: Administration, Topical; Animals; Benzo(a)pyrene; Coal; Diethylnitrosamine; Female; Liver Neoplasms, | 1985 |
Induction of liver tumors in rats by nitrosodiethanolamine at low doses.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Kidney Neoplasms; Liver Neoplasms; Liver Neoplasms | 1985 |
Aldehyde dehydrogenase activities in hepatocyte nodules and hepatocellular carcinomas from Wistar rats.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Animals; Diethylnitrosamine; Kinetics; Liver; Liver N | 1985 |
[Effect of ethanol on the hepatocarcinogenic action of N-nitrosodiethylamine in rats].
Topics: Animals; Diethylnitrosamine; Drug Interactions; Ethanol; Histocytochemistry; Liver; Liver Neoplasms, | 1985 |
[Dynamics and the staging of the histological changes in the liver in experimental diethylnitrosamine carcinogenesis].
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Neoplasm Staging; Rats; Rat | 1985 |
Alkaline phosphatase in rat liver during early stages of experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Diethylnitrosamine; Histocytochemistry; Liver; | 1985 |