diethylnitrosamine has been researched along with Disease Models, Animal in 261 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 8.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 8.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| " In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanoparticles (GaNPs) combined with low level of gamma radiation (IR), on the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 7.91 | Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats. ( El-Sonbaty, SM; Mansour, SZ; Moawed, FS, 2019) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 7.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "We established a new lung adenocarcinoma model using FVB/N mouse strain and diethylnitrosamine." | 7.88 | Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse. ( Baghy, K; Egedi, K; Kovalszky, I; Mervai, Z, 2018) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 7.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 7.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| " Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) increases the drug efficacy on HCCs induced in rats by diethylnitrosamine (DENA)." | 7.73 | Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine. ( Bolondi, L; Busi, C; Chieco, P; Di Stefano, G; Fiume, L; Kratz, F; Lanza, M; Mattioli, A, 2005) |
| " However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and efficacy of hydrodynamic injection via the tail vein and hepatic artery in a diethylnitrosamine (DEN)-induced HCC model in rats." | 7.73 | High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine. ( Hatano, E; Ikai, I; Koizumi, N; Nitta, T; Shimahara, Y; Tada, M; Taura, K, 2006) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 5.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 5.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "Primary hepatic angiosarcoma is a rare tumor with poor prognosis." | 5.51 | Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs. ( Golob-Schwarzl, N; Haybaeck, J; Hofer, EM; Hoppstädter, J; Kessler, SM; Lackner, C; Leber, B; Liegl-Atzwanger, B; Mischinger, HJ; Schultheiss, CS; Stiegler, P, 2019) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 5.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "Caudatin is a potential antitumor agent isolated from the traditional Chinese medicine "baishouwu", which was the root tuber of Cynanchum auriculatum Royle ex Wight." | 5.42 | Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats. ( Ding, Y; Peng, Y, 2015) |
| "Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date." | 5.42 | Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients. ( Hu, C; Huang, X; Lin, X; Niu, J; Tan, Y; Wang, H; Wang, X; Yin, P; Zeng, J; Zhou, L, 2015) |
| "Incidences of lung metastasis in the 40 ppm group steadily increased up to 67% by week 36 while that in the 80 ppm increased sharply up to 86% by week 24." | 5.33 | Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. ( Cho, YM; Futakuchi, M; Imai, N; Ogawa, K; Shirai, T; Takeshita, F; Tamano, S; Yoshino, H, 2005) |
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 4.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "Our results show that the expression of mRNA of IQGAP1, TRAIL decoy receptors, NF-κB, and IL-8 genes was elevated in hepatocellular carcinoma, as compared to normal liver tissue, while their expression was further up-regulated by increasing the dose of diethylnitrosamine." | 4.12 | New Approach about the Signaling Crosstalk between IQGAPs/ NF- κB/IL-8 and PDCD5/p53/TRAIL Pathways that Modulate Malignant Transformation in Hepatocellular Carcinoma. ( Abdelhafez, MA; Darwish, AM; Mahrous, KF; Zoheir, KMA, 2022) |
| "Hepatocellular carcinoma was induced in 40 rats with diethylnitrosamine." | 4.12 | Therapeutic Role of Bone Marrow-Derived Mesenchymal Stem Cells in Controlling Prognosis of Hepatocellular Carcinoma in a Murine Model. ( Abd El Fattah El Sayed, H; Atta, S; Elzayat, E; Hussein, T; Kamel, M; Mahmood, D; Mansour, W; Saber, S, 2022) |
| " Take advantage of the combinatory treatment with a single dose of diethylnitrosamine (DEN) and chronic feeding with high-fat diet (HFD), we demonstrated that hepatic depdc5 deletion did not aggravate DEN&HFD induced liver tumorigenesis, probably due to its protective effects on diet-induced liver steatosis." | 4.02 | Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice. ( Huang, R; Li, Z; Ma, H; Ma, J; Wang, J; Wang, Q; Xiong, X; Xu, L; Yang, C, 2021) |
| "Recently, our group showed that Romidepsin, a histone deacetylase inhibitor (HDACi), suppressed diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in mice." | 4.02 | Romidepsin hepatocellular carcinoma suppression in mice is associated with deregulated gene expression of bone morphogenetic protein and Notch signaling pathway components. ( Afaloniati, H; Angelopoulou, K; Gargavanis, A; Giakoustidis, A; Giakoustidis, D; Poutahidis, T, 2021) |
| " In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis." | 4.02 | Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks. ( Campbell, MJ; Clinton, SK; Coss, CC; Getaneh, S; Helms, TH; Kulp, SK; LeMoine, DM; Lucas, F; Mullins, RD; Phelps, MA; Schmidt, N; Thomas-Ahner, JM; Xie, Z, 2021) |
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 4.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| " In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanoparticles (GaNPs) combined with low level of gamma radiation (IR), on the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 3.91 | Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats. ( El-Sonbaty, SM; Mansour, SZ; Moawed, FS, 2019) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 3.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "We established a new lung adenocarcinoma model using FVB/N mouse strain and diethylnitrosamine." | 3.88 | Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse. ( Baghy, K; Egedi, K; Kovalszky, I; Mervai, Z, 2018) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 3.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| " Hepatocellular Carcinoma (HCC) was induced in the liver of male Sprague Dawley (SD) rats by treating with diethylnitrosamine (DEN)." | 3.85 | In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model. ( Antony Joseph, SR; Krishnan, GS; Rajagopal, V; Savarimuthu, I; Sebastian, D; Selvaraj, KRN; Thobias, AF, 2017) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 3.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| "The purpose of this study was to reduce the time to tumor onset in a diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) swine model via partial liver embolization (PLE) and to characterize the model for use in translational research." | 3.83 | Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs. ( Amin, HM; Avritscher, R; Cressman, E; Eskandari, G; Kaseb, AO; Konnath George, S; Mitchell, J; Morris, JS; Rashid, A; Tinkey, PT; Uthamanthil, R; Van Pelt, C; Xiao, L, 2016) |
| "In this study, we explored whether treatment with FGF-21 could prevent diethylnitrosamine (DEN) induced hepatocarcinogenesis in mice." | 3.81 | Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice. ( Li, D; Liu, M; Liu, Z; Rasoul, LM; Ren, G; Wang, W; Wu, Q; Xu, P; Ye, X; Yuan, Q; Zhang, Y, 2015) |
| " Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals." | 3.81 | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging. ( Fujisawa, K; Furutani-Seiki, M; Matsumoto, T; Nishina, H; Sakaida, I; Takami, T; Terai, S; Yamamoto, N, 2015) |
| " The chemically-induced mouse model of diethylnitrosamine (DEN) provides useful insight into liver carcinogenesis, namely HCC." | 3.80 | The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions. ( Colaço, A; Da Costa, RM; Lopes, C; Oliveira, PA; Paula-Santos, N; Rocha, AF, 2014) |
| "Diethylnitrosamine (DEN) treatment increases the generation of reactive oxygen species (ROS), apoptosis, necrosis and proliferation in the liver." | 3.79 | Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats. ( Başaran-Küçükgergin, C; Bingül, İ; Doğru-Abbasoğlu, S; Olgaç, V; Tekkeşin, MS; Uysal, M, 2013) |
| " In this study, we found that diethylnitrosamine initiation with CCl4 and ethanol promotion could induce a short-term, two-stage liver carcinogenesis model in male BALB/c mice, the process of hepatocarcinogenesis including liver damage, liver necrosis/cell death, liver inflammation, liver proliferation, liver hyperplasia, liver steatosis, and liver cirrhosis and hepatocellular nodules, which mimicked the usual sequence of events observed in human HCC." | 3.79 | Two-stage model of chemically induced hepatocellular carcinoma in mouse. ( Huang, SX; Kuang, ZP; Li, YD; Luo, M; Luo, XL; Wu, JN; Xie, YA; Yang, F, 2013) |
| "To induce chronic cholestasis, Balb/c mice were given 2 weekly intraperitoneal injections of diethylnitrosamine (DEN); 2 weeks later, some mice also received left and median bile duct ligation (LMBDL) and, then 1 week later, were fed DEN, in corn oil, weekly by oral gavage (DLD)." | 3.77 | A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression. ( Aller, MA; Ko, KS; Li, TW; Peng, J; Tang, X; Xia, M; Yang, H, 2011) |
| "Gadolinium-enhanced multi-phase dynamic imaging has improved the accuracy of the diagnosis of hypervascular hepatocellular carcinoma (HCC), but using gadolinium-enhanced dynamic imaging alone is problematic in evaluating hypovascular HCC." | 3.75 | Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents. ( Bian, J; Guo, DM; Liu, SF; Qiu, TS; Wang, CZ, 2009) |
| "Taken together, these findings identify a mechanism of ABT-100 function and show the efficacy of ABT-100 as a chemopreventive agent of hepatocellular carcinoma." | 3.73 | Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent. ( Carloni, V; Pantaleo, P; Vizzutti, F, 2005) |
| " Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) increases the drug efficacy on HCCs induced in rats by diethylnitrosamine (DENA)." | 3.73 | Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine. ( Bolondi, L; Busi, C; Chieco, P; Di Stefano, G; Fiume, L; Kratz, F; Lanza, M; Mattioli, A, 2005) |
| " However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and efficacy of hydrodynamic injection via the tail vein and hepatic artery in a diethylnitrosamine (DEN)-induced HCC model in rats." | 3.73 | High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine. ( Hatano, E; Ikai, I; Koizumi, N; Nitta, T; Shimahara, Y; Tada, M; Taura, K, 2006) |
| "Hepatocellular carcinoma (HCC) was induced by diethylnitrosamine in 70 treated rats with 20 normal rats used as controls." | 3.73 | In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model. ( Li, X; Xie, JX; Xu, H; Yang, ZH, 2006) |
| "We previously found by chance that N-nitrosomorpholine (NMOR) given after a multi-carcinogenic treatment induces liver carcinomas with 56% lung metastasis, and it was confirmed that hepatocellular carcinoma (HCC) with 100% lung metastasis was produced by 24-week treatment with NMOR and additional treatment with diethylnitrosamine (DEN)." | 3.70 | Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model. ( Futakuchi, M; Hirose, M; Kato, K; Ogawa, K; Ogiso, T; Sano, M; Shirai, T, 1999) |
| "We established a cell line (MHB-2) from a hepatoblastoma (HB) induced by diethylnitrosamine (DEN) and sodium phenobarbital (PB) in male B6C3F1 mice and examined the biological characteristics of MHB-2." | 3.70 | Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma. ( Goto, K; Kobayashi, K; Mutai, M; Sakairi, T; Sugimoto, J; Tsuchiya, T, 2000) |
| "Intense pulmonary neuroendocrine cell (PNEC) hyperplasia occurs during preneoplastic lung injury in hamsters treated with diethylnitrosamine (DEN) plus hyperoxia." | 3.69 | Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia. ( Graham, SA; Patidar, K; Sunday, ME; Willett, CG, 1994) |
| "In fact, liver cancer often develops in the context of chronic liver injury." | 2.53 | Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. ( Dhar, D; Karin, M, 2016) |
| "Diethylnitrosamine-induced hepatocellular carcinomas were then investigated in lean and diet-induced obese miR-22-deficient mice." | 1.72 | MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver. ( Ay, AS; Correia de Sousa, M; Delangre, E; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Sempoux, C; Sobolewski, C, 2022) |
| " As a competitor of SHBG-androgen binding, EE2 could bind with SHBG and increase the bioavailability of androgen." | 1.62 | Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin. ( Heo, JH; Hong, EJ; Jeong, SH; Jo, SL; Ko, JW; Kwun, HJ; Lee, SR, 2021) |
| "The remaining 10 rats were the liver cancer model group and treated with diethylnitrosamine (DEN) to induce liver cancer." | 1.62 | Correlation between inflammatory cytokines and liver cancer stem cell markers in DEN-induced liver cancer rats. ( Bai, MJ; Bu, JG; Chen, CY; Li, JQ; Liu, ZH; Yan, SH; Ye, XW, 2021) |
| "The DEN-challenged liver cancer in experimental rats caused increased liver weight, 8-OHD, hepatic tissue injury marker, lipid peroxidation, and tumor markers levels." | 1.62 | Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells. ( Alahmadi, TA; Chinnathambi, A; Li, Z; Lu, B; Xie, Y; You, Y; Zhang, L; Zhu, F, 2021) |
| "All mice administered oral DEN developed liver fibrosis, liver cirrhosis and hepatocellular carcinoma (HCC)." | 1.56 | Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis. ( Bai, L; Chen, Q; Jiang, S; Lai, J; Yang, W; You, X; Zhang, H, 2020) |
| "And Wrh-f2 developed stable pulmonary metastasis." | 1.56 | Establishment of rat liver cancer cell lines with different metastatic potential. ( Feng, X; Hou, J; Liu, SF; Song, L; Zhang, HL; Zhang, JG; Zheng, L, 2020) |
| "Diethylnitrosamine (DEN) was used to induce HCC in a high-fat diet (HFD)-induced multigenerational obesity model." | 1.56 | Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p. ( Geng, M; Huang, K; Liu, S; Liu, Y; Petersen, RB; Sun, Y; Wang, Q; Wei, Y; Yue, J; Zhang, Y; Zheng, L, 2020) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 1.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| "The present study used human hepatoma cell lines and rats with diethylnitrosamine (DEN)‑induced HCC as models to investigate the association between the effect of EGCG on liver cancer and regulation of the p21waf1/Cip1/CDC25A axis." | 1.56 | Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A. ( An, H; Cai, Z; Cao, J; Chen, N; Li, K; Li, Y; Luo, A; Peng, Y; Tang, Y; Tao, H, 2020) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 1.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "Hepatitis and hepatocellular carcinoma are serious human diseases." | 1.51 | Extracts of Qizhu decoction inhibit hepatitis and hepatocellular carcinoma in vitro and in C57BL/6 mice by suppressing NF-κB signaling. ( Fang, NY; Shen, JJ; Wan, LF; Wang, YH; Xue, BY; Yuan, X; Zhao, W, 2019) |
| "Primary hepatic angiosarcoma is a rare tumor with poor prognosis." | 1.51 | Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs. ( Golob-Schwarzl, N; Haybaeck, J; Hofer, EM; Hoppstädter, J; Kessler, SM; Lackner, C; Leber, B; Liegl-Atzwanger, B; Mischinger, HJ; Schultheiss, CS; Stiegler, P, 2019) |
| "In the NAFLD pigs, hepatic histology of nonalcoholic steatohepatitis (NASH) was observed at 36 weeks, and HCC developed at 60 weeks." | 1.51 | Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study. ( Aizawa, N; Hatano, E; Iguchi, K; Iijima, H; Ikegawa, M; Kawaguchi, H; Nakamura, N; Nishiguchi, S; Ohtsu, I; Okuda, Y; Sakurai, T; Sato, M; Seo, S; Taura, K; Tomono, T; Uemoto, S; Wada, S, 2019) |
| "The most common form of liver cancer is hepatocellular carcinoma (HCC)." | 1.48 | WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia. ( Abu-Remaileh, M; Aqeilan, RI; Khalaileh, A; Pikarsky, E, 2018) |
| "In a nutritional model of hepatocarcinogenesis, the protein Nrf2 is frequently mutated/activated at early steps of the tumorigenic process." | 1.48 | Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. ( Columbano, A; Orrù, C; Perra, A; Szydlowska, M; Taguchi, K; Yamamoto, M; Zavattari, P, 2018) |
| "Induced liver cancer mice showed depressed mental status, early onset of hepatitis and liver cirrhosis." | 1.48 | Investigation of PD-1H in DEN-induced mouse liver cancer model. ( Lei, CJ; Li, Y; Long, ZX; Pan, QY; Ren, H; Wang, B, 2018) |
| "At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally." | 1.48 | The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice. ( Chen, XZ; Li, XJ; Li, YS; Shang, HC; Tang, HB; Tian, GH; Zhang, WK, 2018) |
| "In the DEN-treated mice, AICAR treatment reduced tumorigenesis, IL-6 signaling, and STAT3 activation." | 1.48 | The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN). ( Gao, J; Jiang, G; Xiong, D; Xiong, R; Yin, T; Yin, Z; Zhang, S; Zhang, X; Zhao, W, 2018) |
| "Human hepatocellular carcinomas (HCCs), which arise on a background of chronic liver damage and inflammation, express c-Fos, a component of the AP-1 transcription factor." | 1.46 | Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation. ( Bakiri, L; Campos-Olivas, R; Dienes, HP; Graña, O; Guío-Carrión, A; Hamacher, R; Hasenfuss, SC; Martinez, L; Thomsen, MK; Wagner, EF, 2017) |
| "Examination of liver cancer in diethylnitrosamine (DEN)-treated CUGBP1-S302A mice showed these mice develop much more severe liver cancer that is associated with elimination of the mutant CUGBP1." | 1.46 | RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner. ( Cast, A; Iakova, P; Karns, R; Lewis, K; Stock, L; Timchenko, L; Timchenko, N; Valanejad, L; Wei, C; Wright, M, 2017) |
| "Non-alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of conditions, ranging from non-progressive bland steatosis to hepatocarcinoma." | 1.46 | Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. ( Bischetti, S; Casagrande, V; Federici, M; Mauriello, A; Mavilio, M; Menghini, R, 2017) |
| "Hepatocellular carcinoma was induced with 20 mg diethylnitrosamine/kg BW." | 1.46 | Gamma-irradiated β-glucan modulates signaling molecular targets of hepatocellular carcinoma in rats. ( Elsonbaty, SM; Moawed, FS; Zahran, WE, 2017) |
| "The adenosine derivative treatment reduced diethylnitrosamine-induced collagen expression and decreased the proportion of nodules positive for the tumor marker γ-glutamyl transferase." | 1.46 | Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats. ( Chagoya de Sánchez, V; Pérez-Carreón, JI; Pérez-Martínez, L; Velasco-Loyden, G; Vidrio-Gómez, S, 2017) |
| "Wister rat model of liver cancer was set up using diethylnitrosamine (DEN)." | 1.43 | Correlation between angiogenic/inflammatory mediators in Wister rat model of liver dysplasia. ( Adel, S; Nasr, MI; Salem, TA; Talaat, RM, 2016) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 1.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "Many animal models of nonalcoholic steatohepatitis have been reported." | 1.43 | A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis. ( Ejima, C; Ishizaki, S; Kuroda, H, 2016) |
| "Curcumin treatment partially reversed DENA-induced damage as it reduced the overexpression of the angiogenic and anti-apoptotic factors TGF-β and Akt and improved caspase-3 expression." | 1.42 | Curcumin ameliorate DENA-induced HCC via modulating TGF-β, AKT, and caspase-3 expression in experimental rat model. ( Abd El-Aziz, EA; Abd El-Aziz, HO; Abd El-Ghany, AA; Abdel Aziz, MA; Abouzied, MM; Ahmed, NS; Eltahir, HM, 2015) |
| "Sorafenib treatment restored mitochondrial function and reduced collagen deposition by nearly 63% compared to the NASH group." | 1.42 | Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model. ( Barbeiro, DF; Bida, PM; Carrilho, FJ; Coelho, AM; Cogliati, B; D'Albuquerque, LA; Kubrusly, MS; Mazo, DF; Oliveira, CP; Pereira, IV; Souza, HP; Stefano, JT; Torres, MM; Xerfan, MP, 2015) |
| "Caudatin is a potential antitumor agent isolated from the traditional Chinese medicine "baishouwu", which was the root tuber of Cynanchum auriculatum Royle ex Wight." | 1.42 | Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats. ( Ding, Y; Peng, Y, 2015) |
| "Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear." | 1.42 | Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015) |
| "Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date." | 1.42 | Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients. ( Hu, C; Huang, X; Lin, X; Niu, J; Tan, Y; Wang, H; Wang, X; Yin, P; Zeng, J; Zhou, L, 2015) |
| "Alcoholic liver disease, chronic hepatitis B and chronic hepatitis C are the most common underlying liver diseases." | 1.40 | Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53. ( Calabrese, D; Dietsche, T; Dill, MT; Duong, FH; Heim, MH; Ketterer, S; Makowska, Z; Matter, MS; Terracciano, L, 2014) |
| "A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used." | 1.40 | Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014) |
| "To establish a zebrafish model of liver fibrosis via diethylnitrosamine (DEN)-induced liver injury." | 1.40 | [Establishment of a hepatic fibrosis model induced by diethylnitrosamine in zebrafish]. ( Chen, X; Dai, W; Hou, J; Liu, L; Wang, K; Zheng, X, 2014) |
| "Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis." | 1.40 | The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014) |
| "The percentage of liver fibrosis was assessed via quantitative analysis of Masson trichrome staining using an average of 30 fields per section." | 1.39 | Intra-voxel incoherent motion MRI in rodent model of diethylnitrosamine-induced liver fibrosis. ( Deng, J; Guo, Y; Jin, N; Larson, AC; Omary, RA; White, SB; Yang, GY; Zhang, Y, 2013) |
| "Phenobarbital (PB) is a cytochrome P450 (CYP) 2B inducer, and piperonyl butoxide (PBO) is a CYP1A/2B inducer." | 1.39 | Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide. ( Akane, H; Itahashi, M; Mitsumori, K; Morita, R; Nakane, F; Shibutani, M; Shiraki, A; Suzuki, K; Yafune, A, 2013) |
| " indica leaf extract (AAILE) was administered orally at a dosage of 100 μg/g body weight thrice a week till termination of the study." | 1.38 | Azadirachta indica exhibits chemopreventive action against hepatic cancer: Studies on associated histopathological and ultrastructural changes. ( Bharati, S; Koul, A; Rishi, P, 2012) |
| "Diethylnitrosamine metabolism was measured based on nitrite formation and liver histology using GGT histochemistry." | 1.38 | Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis. ( Beltrán-Ramírez, O; Pérez, RM; Sierra-Santoyo, A; Villa-Treviño, S, 2012) |
| "Decreased KLF6 expression in human hepatocellular carcinoma (HCC) correlates with increased mortality, but the contribution of increased SV1 is unknown." | 1.38 | Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing. ( Cohen-Naftaly, M; Friedman, SL; Hannivoort, R; Kocabayoglu, P; Lee, YA; M Llovet, J; Narla, G; Thung, SN; Vetter, D; Villanueva, A, 2012) |
| "Molecular MRI of liver fibrosis with a collagen-specific probe identifies fibrotic tissue in two rodent models of disease." | 1.38 | Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models. ( Alford, JK; Caravan, P; Fuchs, BC; Guimaraes, AR; Lauwers, GY; Loving, GS; Polasek, M; Schühle, DT; Tanabe, KK; Uppal, R; Wei, L; Yamada, S, 2012) |
| "Liver tumor, especially hepatocellular carcinoma (HCC), is closely associated with chronic inflammation." | 1.38 | Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. ( Gan, Y; He, C; Huang, W; Lou, G; Meng, Z; Ness, CV; Wang, X; Wu, J; Xu, R; Yu, H; Zhang, Y; Zhou, H, 2012) |
| " These results provide a rationale for long-term MET dosing in future clinical trials of HCC treatment." | 1.37 | Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma. ( Bae, SH; Choi, JY; Jang, JW; Jung, CK; Kwon, JH; Park, ST; Yoon, SK; You, CR, 2011) |
| " In the present study, the authors treated C57BL/6 mice with 25, 50, and 75 mg/kg of diethylnitrosamine (DEN) for 4 or 8 weeks by intraperitoneal injection to investigate the dose-response pattern of preneoplastic and neoplastic lesion formation in the liver." | 1.37 | Dose-related induction of hepatic preneoplastic lesions by diethylnitrosamine in C57BL/6 mice. ( Kamendulis, LM; Klaunig, JE; Kushida, M; Peat, TJ, 2011) |
| "Phosphorylated STAT3 was found in human hepatocellular carcinoma tissue samples and was expressed in tumor cells and also in monocytes." | 1.37 | STAT3 activation in monocytes accelerates liver cancer progression. ( Li, J; Meng, XL; Wu, WY; Wu, ZS; Zhang, CL, 2011) |
| "p53 Mutations are very common in human hepatocellular carcinoma, and induction of hepatic p53 expression causes lysis of implanted hepatoblastoma cells in a chimeric mouse." | 1.36 | Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. ( Dan, YY; Farrell, G; Fausto, N; Gu, Y; Hou, J; Mitchell, C; Pyakurel, P; Swisshelm, K; Teoh, N, 2010) |
| "Also, hepatoma cells use PDGFRalpha/PIK3CA signaling as an escape mechanism following beta-catenin suppression, and their sequential suppression profoundly impedes tumor proliferation." | 1.36 | Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. ( Kim, Y; Klaunig, JE; Misse, A; Monga, SP; Singh, S; Tan, X; Zeng, G; Zhang, XF, 2010) |
| "Chromosomal instability is a characteristic feature of hepatocellular carcinoma (HCC) but its origin and role in liver carcinogenesis are undefined." | 1.35 | Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice. ( Dan, YY; Fausto, N; Gu, Y; Haque, J; Lehman, S; Swisshelm, K; Teoh, NC; Wright, JH, 2008) |
| "Fenofibrate (FF) has previously been shown to induce hepatocellular neoplasia in a conventional mouse bioassay (NDA 1993), but there has been no report to examine the carcinogenic susceptibility of rasH2 mice to this chemical." | 1.35 | Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice. ( Dewa, Y; Jin, M; Kawai, M; Matsumoto, S; Mitsumori, K; Nishimura, J; Saegusa, Y; Shibutani, M; Taniai, E, 2008) |
| "In the liver cirrhosis and liver cancer group, Mphi had more prominences, meanwhile much more mitochondria, ribosome, rough endoplasmic reticulum, lysosome can be found in the cytoplasm, especially in the liver cancer group." | 1.35 | Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats. ( Huang, C; Li, ZF; Liu, ZW; Pan, D; Zhang, S; Zhou, R, 2009) |
| "Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN)." | 1.35 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis. ( Bozova, S; Elpek, GO; Gokhan, GA, 2008) |
| "5 ppm vanadium is potentially and optimally effective, as derived from dose-response studies, in limiting early molecular events and preneoplastic lesions, thereby modulating the initiation stage of hepatocarcinogenesis." | 1.34 | Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Dhachinamoorthi, D; Kumar P, A; Rana, A, 2007) |
| "Cyclohexanol is a basic industrial chemical widely used because of its versatility as an industrial solvent." | 1.34 | Co-carcinogenic effect of cyclohexanol on the development of preneoplastic lesions in a rat hepatocarcinogenesis model. ( Alemán-Lazarini, L; Arce-Popoca, E; Cabrales-Romero, Mdel P; Carrasco-Legleu, CE; Fatel-Fazenda, S; Márquez-Rosado, L; Sierra-Santoyo, A; Trejo-Solís, C; Villa-Treviño, S, 2007) |
| "Incidences of lung metastasis in the 40 ppm group steadily increased up to 67% by week 36 while that in the 80 ppm increased sharply up to 86% by week 24." | 1.33 | Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. ( Cho, YM; Futakuchi, M; Imai, N; Ogawa, K; Shirai, T; Takeshita, F; Tamano, S; Yoshino, H, 2005) |
| " This research confirms the effectiveness of the DEN in bringing about carcinogenesis in the Wistar rat esophagus and also shows that the lesions are dosage dependent." | 1.31 | Experimental esophageal carcinogenesis: technical standardization and results. ( Andreollo, NA; Eshkenazy, R; Pajecki, D; Sallet, JA; Zilberstein, B, 2002) |
| " Polyen antibiotics combined with DMSO also demonstrated antineoplastic activity at the animals treated with carcinogenic agent--diethyl nitrosoamine (DENA)." | 1.31 | [Radioprotective and antineoplastic activity of polyene antibiotics combined with dimethyl sulfoxide]. ( Aliev, DI; Ibragimova, VKh, 2002) |
| "In CDAA-induced liver fibrosis model, PE revealed a marked inhibitory effect of liver fibrosis development." | 1.31 | Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. ( Fukui, H; Ikenaka, Y; Imazu, H; Kuriyama, S; Nakatani, T; Noguchi, R; Tsujinoue, H; Yanase, K; Yoshii, J; Yoshiji, H, 2002) |
| "Tamoxifen is a well-tolerated palliative and adjuvant treatment for human breast cancer and requires continuous, long-term administration for optimal therapeutic effectiveness." | 1.28 | Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis. ( Dragan, YP; Pitot, HC; Xu, YD, 1991) |
| "Aneuploidy was also present, as expected, in 4 of 33 AHF in the animals placed on CD + PHB." | 1.28 | Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model. ( Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM, 1990) |
| "diethylnitrosamine." | 1.28 | Differential susceptibility of a fish, tilapia Oreochromis mossambicus (Teleostei, Cichlidae) to hepatocarcinogenesis by diethylnitrosamine and methylazoxymethanol acetate. ( Ding, JL; Hee, PL; Lam, TJ, 1989) |
| "Neuroendocrine lung cancer is among the most common types of lung tumor in man and demonstrates a strong etiological association with cigarette smoking." | 1.27 | An animal model for neuroendocrine lung cancer. ( Becker, KL; Schuller, HM; Witschi, HP, 1988) |
| " The analysis of dose-response data showed first order kinetics (single event) regarding the induction of intermediate basophilic foci (IBF) and hepatocellular carcinomas (HCC)." | 1.27 | Certain aspects of hepatocarcinogenesis in the infant mouse model. ( Vesselinovitch, SD, 1987) |
| "Diethylnitrosamine is known to cause squamous cell carcinoma and adenocarcinoma of the lung in Syrian golden hamsters." | 1.26 | Lung endocrine-like cells in hamsters treated with diethylnitrosamine: alterations in vivo and in cell culture. ( DiAugustine, RP; Linnoila, RI; Nettesheim, P, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (5.36) | 18.7374 |
| 1990's | 30 (11.49) | 18.2507 |
| 2000's | 55 (21.07) | 29.6817 |
| 2010's | 135 (51.72) | 24.3611 |
| 2020's | 27 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, L | 1 |
| Yang, C | 3 |
| Wang, J | 2 |
| Li, Z | 3 |
| Huang, R | 1 |
| Ma, H | 1 |
| Ma, J | 1 |
| Wang, Q | 2 |
| Xiong, X | 1 |
| Haberl, EM | 3 |
| Pohl, R | 3 |
| Rein-Fischboeck, L | 3 |
| Höring, M | 2 |
| Krautbauer, S | 3 |
| Liebisch, G | 3 |
| Buechler, C | 3 |
| Ghufran, H | 1 |
| Azam, M | 1 |
| Mehmood, A | 1 |
| Butt, H | 1 |
| Riazuddin, S | 1 |
| Márquez-Quiroga, LV | 1 |
| Arellanes-Robledo, J | 1 |
| Vásquez-Garzón, VR | 1 |
| Villa-Treviño, S | 3 |
| Muriel, P | 1 |
| Lee, SR | 2 |
| Jeong, SH | 1 |
| Heo, JH | 1 |
| Jo, SL | 1 |
| Ko, JW | 1 |
| Kwun, HJ | 1 |
| Hong, EJ | 2 |
| Men, H | 1 |
| Young, JL | 1 |
| Zhou, W | 1 |
| Zhang, H | 2 |
| Wang, X | 7 |
| Xu, J | 1 |
| Lin, Q | 1 |
| Tan, Y | 2 |
| Zheng, Y | 1 |
| Cai, L | 1 |
| Zoheir, KMA | 1 |
| Abdelhafez, MA | 1 |
| Darwish, AM | 1 |
| Mahrous, KF | 1 |
| Gjorgjieva, M | 1 |
| Ay, AS | 1 |
| Correia de Sousa, M | 1 |
| Delangre, E | 1 |
| Dolicka, D | 1 |
| Sobolewski, C | 1 |
| Maeder, C | 1 |
| Fournier, M | 1 |
| Sempoux, C | 1 |
| Foti, M | 1 |
| Giri, SR | 1 |
| Bhoi, B | 1 |
| Trivedi, C | 1 |
| Rath, A | 1 |
| Rathod, R | 1 |
| Sharma, A | 1 |
| Ranvir, R | 1 |
| Kadam, S | 1 |
| Ingale, K | 1 |
| Patel, H | 1 |
| Nyska, A | 1 |
| Jain, MR | 1 |
| Kim, JY | 1 |
| Han, YH | 1 |
| Nam, MW | 1 |
| Kim, HJ | 1 |
| Lee, MO | 1 |
| Guedj, A | 1 |
| Volman, Y | 1 |
| Geiger-Maor, A | 1 |
| Bolik, J | 1 |
| Schumacher, N | 1 |
| Künzel, S | 1 |
| Baines, JF | 1 |
| Nevo, Y | 1 |
| Elgavish, S | 1 |
| Galun, E | 1 |
| Amsalem, H | 1 |
| Schmidt-Arras, D | 1 |
| Rachmilewitz, J | 1 |
| Mello, T | 1 |
| Materozzi, M | 1 |
| Zanieri, F | 1 |
| Simeone, I | 1 |
| Ceni, E | 1 |
| Bereshchenko, O | 1 |
| Polvani, S | 1 |
| Tarocchi, M | 1 |
| Marroncini, G | 1 |
| Nerlov, C | 1 |
| Guasti, D | 1 |
| Bani, D | 1 |
| Pinzani, M | 1 |
| Galli, A | 1 |
| Chen, Q | 1 |
| You, X | 1 |
| Yang, W | 2 |
| Jiang, S | 1 |
| Lai, J | 1 |
| Bai, L | 1 |
| Feder, S | 1 |
| Sinal, CJ | 1 |
| Bruckmann, A | 1 |
| Hoering, M | 1 |
| El-Ahwany, E | 1 |
| Mansy, SS | 1 |
| Zoheiry, M | 1 |
| Mourad, L | 1 |
| Mahmoud, S | 1 |
| Abu-Taleb, H | 1 |
| Hassanien, M | 1 |
| Hassan, M | 1 |
| Matsuoka, Y | 2 |
| Izumi, Y | 1 |
| Takahashi, M | 1 |
| Bamba, T | 1 |
| Yamada, KI | 1 |
| Song, L | 1 |
| Zhang, JG | 1 |
| Zheng, L | 2 |
| Feng, X | 1 |
| Hou, J | 3 |
| Zhang, HL | 1 |
| Liu, SF | 2 |
| Sun, Y | 3 |
| Zhang, Y | 4 |
| Geng, M | 1 |
| Wei, Y | 2 |
| Liu, Y | 2 |
| Liu, S | 1 |
| Petersen, RB | 1 |
| Yue, J | 1 |
| Huang, K | 1 |
| Memon, A | 1 |
| Pyao, Y | 1 |
| Jung, Y | 1 |
| Lee, JI | 1 |
| Lee, WK | 1 |
| Landerer, S | 1 |
| Kalthoff, S | 1 |
| Paulusch, S | 1 |
| Strassburg, CP | 1 |
| Tang, Y | 1 |
| Cao, J | 3 |
| Cai, Z | 1 |
| An, H | 1 |
| Li, Y | 3 |
| Peng, Y | 2 |
| Chen, N | 2 |
| Luo, A | 1 |
| Tao, H | 1 |
| Li, K | 1 |
| Afaloniati, H | 1 |
| Poutahidis, T | 1 |
| Giakoustidis, A | 1 |
| Gargavanis, A | 1 |
| Giakoustidis, D | 1 |
| Angelopoulou, K | 1 |
| Helms, TH | 1 |
| Mullins, RD | 1 |
| Thomas-Ahner, JM | 1 |
| Kulp, SK | 1 |
| Campbell, MJ | 1 |
| Lucas, F | 1 |
| Schmidt, N | 1 |
| LeMoine, DM | 1 |
| Getaneh, S | 1 |
| Xie, Z | 1 |
| Phelps, MA | 1 |
| Clinton, SK | 1 |
| Coss, CC | 1 |
| Liu, ZH | 1 |
| Bai, MJ | 1 |
| Li, JQ | 1 |
| Yan, SH | 1 |
| Ye, XW | 1 |
| Bu, JG | 1 |
| Chen, CY | 1 |
| You, Y | 1 |
| Zhu, F | 1 |
| Zhang, L | 2 |
| Xie, Y | 1 |
| Chinnathambi, A | 1 |
| Alahmadi, TA | 1 |
| Lu, B | 1 |
| Raffaele, M | 1 |
| Kovacovicova, K | 1 |
| Frohlich, J | 1 |
| Lo Re, O | 1 |
| Giallongo, S | 1 |
| Oben, JA | 1 |
| Faldyna, M | 1 |
| Leva, L | 1 |
| Giannone, AG | 1 |
| Cabibi, D | 1 |
| Vinciguerra, M | 1 |
| Julian, L | 1 |
| Naylor, G | 1 |
| Wickman, GR | 1 |
| Rath, N | 1 |
| Castino, G | 1 |
| Stevenson, D | 1 |
| Bryson, S | 1 |
| Munro, J | 1 |
| McGarry, L | 1 |
| Mullin, M | 1 |
| Rice, A | 1 |
| Del Río Hernández, A | 1 |
| Olson, MF | 1 |
| Mansour, W | 1 |
| Kamel, M | 2 |
| Elzayat, E | 1 |
| Atta, S | 1 |
| Mahmood, D | 1 |
| Abd El Fattah El Sayed, H | 1 |
| Hussein, T | 1 |
| Saber, S | 1 |
| Bakiri, L | 1 |
| Hamacher, R | 1 |
| Graña, O | 1 |
| Guío-Carrión, A | 1 |
| Campos-Olivas, R | 1 |
| Martinez, L | 1 |
| Dienes, HP | 1 |
| Thomsen, MK | 1 |
| Hasenfuss, SC | 1 |
| Wagner, EF | 1 |
| Mahmoud, AM | 1 |
| Zaki, AR | 1 |
| Hassan, ME | 1 |
| Mostafa-Hedeab, G | 1 |
| Kiefer, RM | 1 |
| Hunt, SJ | 1 |
| Pulido, S | 1 |
| Pickup, S | 1 |
| Furth, EE | 1 |
| Soulen, MC | 1 |
| Nadolski, GJ | 1 |
| Gade, TP | 1 |
| Lewis, K | 1 |
| Valanejad, L | 1 |
| Cast, A | 1 |
| Wright, M | 1 |
| Wei, C | 2 |
| Iakova, P | 1 |
| Stock, L | 1 |
| Karns, R | 1 |
| Timchenko, L | 1 |
| Timchenko, N | 1 |
| Fu, Y | 1 |
| Silverstein, S | 1 |
| McCutcheon, JN | 1 |
| Dyba, M | 1 |
| Nath, RG | 1 |
| Aggarwal, M | 1 |
| Coia, H | 1 |
| Bai, A | 1 |
| Pan, J | 1 |
| Jiang, J | 1 |
| Kallakury, B | 1 |
| Wang, H | 3 |
| Zhang, YW | 1 |
| Giaccone, G | 1 |
| He, AR | 1 |
| Chung, FL | 1 |
| Casagrande, V | 1 |
| Mauriello, A | 1 |
| Bischetti, S | 1 |
| Mavilio, M | 1 |
| Federici, M | 1 |
| Menghini, R | 1 |
| Elsonbaty, SM | 1 |
| Zahran, WE | 1 |
| Moawed, FS | 2 |
| Fathy, AH | 1 |
| Bashandy, MA | 1 |
| Bashandy, SAE | 1 |
| Mansour, AM | 1 |
| Elsadek, B | 1 |
| Moreno-Marín, N | 1 |
| Barrasa, E | 1 |
| Morales-Hernández, A | 1 |
| Paniagua, B | 1 |
| Blanco-Fernández, G | 1 |
| Merino, JM | 1 |
| Fernández-Salguero, PM | 1 |
| Krishnan, GS | 1 |
| Rajagopal, V | 1 |
| Antony Joseph, SR | 1 |
| Sebastian, D | 1 |
| Savarimuthu, I | 1 |
| Selvaraj, KRN | 1 |
| Thobias, AF | 1 |
| Song, LY | 1 |
| Ma, YT | 1 |
| Wu, CF | 1 |
| Wang, CJ | 1 |
| Fang, WJ | 1 |
| Liu, SK | 1 |
| He, Q | 1 |
| Wang, F | 2 |
| Honda, T | 1 |
| Lindquist, DM | 1 |
| Dillman, JR | 1 |
| Timchenko, NA | 1 |
| Redington, AN | 1 |
| Mervai, Z | 1 |
| Egedi, K | 1 |
| Kovalszky, I | 1 |
| Baghy, K | 1 |
| Zaazaa, AM | 1 |
| Lokman, MS | 1 |
| Shalby, AB | 1 |
| Ahmed, HH | 1 |
| El-Toumy, SA | 1 |
| Guo, X | 1 |
| Noguchi, H | 1 |
| Ishii, N | 1 |
| Homma, T | 1 |
| Hamada, T | 1 |
| Hiraki, T | 1 |
| Zhang, J | 1 |
| Matsuo, K | 1 |
| Yokoyama, S | 1 |
| Ishibashi, H | 1 |
| Fukushige, T | 1 |
| Kanekura, T | 1 |
| Fujii, J | 1 |
| Uramoto, H | 1 |
| Tanimoto, A | 1 |
| Yamada, S | 3 |
| Kot, M | 1 |
| Daujat-Chavanieu, M | 1 |
| Abu-Remaileh, M | 1 |
| Khalaileh, A | 1 |
| Pikarsky, E | 1 |
| Aqeilan, RI | 1 |
| Pittala, S | 1 |
| Krelin, Y | 1 |
| Shoshan-Barmatz, V | 1 |
| Orrù, C | 1 |
| Szydlowska, M | 1 |
| Taguchi, K | 1 |
| Zavattari, P | 1 |
| Perra, A | 2 |
| Yamamoto, M | 1 |
| Columbano, A | 2 |
| Connor, F | 1 |
| Rayner, TF | 1 |
| Aitken, SJ | 1 |
| Feig, C | 1 |
| Lukk, M | 1 |
| Santoyo-Lopez, J | 1 |
| Odom, DT | 1 |
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6 reviews available for diethylnitrosamine and Disease Models, Animal
| Article | Year |
|---|---|
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Diseas | 2022 |
Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Hepa | 2016 |
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; G | 2002 |
N-nitrosodiethanolamine.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cricetinae; Diethylnitrosamine; Disease Models, Animal; | 2000 |
[Basic research on lung cancer].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Genes, Tumor Suppressor; Growth Substances; His | 2002 |
Model studies in tobacco carcinogenesis with the Syrian golden hamster.
Topics: Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; Disease Models, | 1979 |
255 other studies available for diethylnitrosamine and Disease Models, Animal
| Article | Year |
|---|---|
Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diet, High-Fat; Diethylni | 2021 |
Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice.
Topics: Animals; Carcinoma, Hepatocellular; Ceramides; Cholesterol; Diethylnitrosamine; Disease Models, Anim | 2021 |
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamin | 2021 |
Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin.
Topics: Androgens; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Disease P | 2021 |
Early-Life Exposure to Low-Dose Cadmium Accelerates Diethylnitrosamine and Diet-Induced Liver Cancer.
Topics: Animals; Animals, Newborn; Cadmium; Choline; Diet, High-Fat; Diethylnitrosamine; Disease Models, Ani | 2021 |
New Approach about the Signaling Crosstalk between IQGAPs/ NF- κB/IL-8 and PDCD5/p53/TRAIL Pathways that Modulate Malignant Transformation in Hepatocellular Carcinoma.
Topics: Animals; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2022 |
MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Fatt | 2022 |
Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; Diet, High-Fat; Diethylnitrosamine; Diseas | 2023 |
RORα suppresses interleukin-6-mediated hepatic acute phase response.
Topics: Acute-Phase Reaction; Adenoviridae; Animals; Chemical and Drug Induced Liver Injury; Chemokine CXCL1 | 2019 |
Gut microbiota shape 'inflamm-ageing' cytokines and account for age-dependent decline in DNA damage repair.
Topics: Aging; Animals; Anti-Bacterial Agents; Cytokines; Diethylnitrosamine; Disease Models, Animal; DNA Da | 2020 |
Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carcinogenesis; Carcinoma, Hepatocellu | 2020 |
Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Inflammation; Liver; | 2020 |
Overexpression of Hepatocyte Chemerin-156 Lowers Tumor Burden in a Murine Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Chemokines; Cholesterol; Diethylnitrosamine; Diglycerides; Disea | 2019 |
MicroRNA-195 vector influence on the development of gradually induced hepatocellular carcinoma in murine model.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Liver N | 2020 |
Method for Structural Determination of Lipid-Derived Radicals.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Free Radicals; Injections, Intraperitoneal; Lip | 2020 |
Establishment of rat liver cancer cell lines with different metastatic potential.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Disease Models, Animal; Ka | 2020 |
Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Animals; Carcinoma, Hepatocellular; Coenzyme A Ligases; Diet, | 2020 |
A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2020 |
UDP-glucuronosyltransferase polymorphisms affect diethylnitrosamine-induced carcinogenesis in humanized transgenic mice.
Topics: Animals; Biopsy; Carcinogenesis; Diethylnitrosamine; Disease Models, Animal; Enzyme Activation; Fema | 2020 |
Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Catechin; cdc25 Phosphatases; | 2020 |
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Def | 2020 |
Romidepsin hepatocellular carcinoma suppression in mice is associated with deregulated gene expression of bone morphogenetic protein and Notch signaling pathway components.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Carcinoma, Hepatocellular; Cell | 2021 |
Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks.
Topics: Androgens; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; | 2021 |
Correlation between inflammatory cytokines and liver cancer stem cell markers in DEN-induced liver cancer rats.
Topics: Administration, Oral; Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Chemokine CCL2; Die | 2021 |
Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Bi | 2021 |
Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin.
Topics: Aging; Animals; Dasatinib; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Disease Progr | 2021 |
Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Shape; Chemical and Drug Induced Liver | 2021 |
Therapeutic Role of Bone Marrow-Derived Mesenchymal Stem Cells in Controlling Prognosis of Hepatocellular Carcinoma in a Murine Model.
Topics: Animals; Bone Marrow; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Humans; | 2022 |
Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cholesterol; Diethylnitrosamine | 2017 |
Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Heme Oxygenase-1; Inflammat | 2017 |
Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Emboliz | 2017 |
RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.
Topics: Aging; Animals; Carcinogenesis; CELF1 Protein; Child; Diethylnitrosamine; Disease Models, Animal; E2 | 2017 |
An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease M | 2018 |
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Topics: ADAM17 Protein; Albumins; Animals; ATP Binding Cassette Transporter, Subfamily B; Carcinogenesis; Ca | 2017 |
Gamma-irradiated β-glucan modulates signaling molecular targets of hepatocellular carcinoma in rats.
Topics: Animals; beta-Glucans; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gamma | 2017 |
Sequential analysis and staging of a diethylnitrosamine-induced hepatocellular carcinoma in male Wistar albino rat model.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Lipids; | 2017 |
Dioxin Receptor Adjusts Liver Regeneration After Acute Toxic Injury and Protects Against Liver Carcinogenesis.
Topics: Animals; Biomarkers; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Diethy | 2017 |
In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biomarkers, Tumor; Body Weight; Carcinoma, Hepatocellu | 2017 |
MicroRNA-195 Activates Hepatic Stellate Cells In Vitro by Targeting Smad7.
Topics: 3' Untranslated Regions; Animals; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regula | 2017 |
Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Administration, Intravenous; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Pro | 2017 |
Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse.
Topics: Adenocarcinoma; Animals; Base Sequence; Biomarkers, Tumor; Diethylnitrosamine; Disease Models, Anima | 2018 |
Ellagic Acid Holds Promise Against Hepatocellular Carcinoma\
in an Experimental Model: Mechanisms of Action
Topics: Alkylating Agents; alpha-Fetoproteins; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cells, | 2018 |
The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
Topics: Aged; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cohort St | 2019 |
Altered cytokine profile under control of the serotonergic system determines the regulation of CYP2C11 and CYP3A isoforms.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Body Weight; Cytochrome P-450 CYP3A; Cytochrome | 2018 |
WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diet, High-Fat; Diethylnit | 2018 |
Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosam | 2018 |
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosa | 2018 |
Mutational landscape of a chemically-induced mouse model of liver cancer.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; DNA Copy Number Variations; Exome; Genes, ras; | 2018 |
Investigation of PD-1H in DEN-induced mouse liver cancer model.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Disease Models, Animal; Humans; Liver Neoplasms; Mal | 2018 |
Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma.
Topics: Animals; Cell Proliferation; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Female; Gen | 2018 |
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an | 2019 |
Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Drug Synergism; Female; Injections | 2018 |
The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransfera | 2018 |
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High- | 2019 |
STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytokines; Diethylni | 2019 |
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcino | 2018 |
Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats.
Topics: Angiotensin Receptor Antagonists; Animals; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cell Tr | 2018 |
Extracts of Qizhu decoction inhibit hepatitis and hepatocellular carcinoma in vitro and in C57BL/6 mice by suppressing NF-κB signaling.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herba | 2019 |
Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter.
Topics: Adenocarcinoma of Lung; Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Diethylnitrosamine; | 2019 |
Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; Disease Models, A | 2019 |
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Topics: alpha-Fetoproteins; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2019 |
NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Mod | 2019 |
Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 2019 |
Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs.
Topics: Animals; Biomarkers, Tumor; Diethylnitrosamine; Disease Models, Animal; Hemangiosarcoma; Liver Neopl | 2019 |
Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Carcinoma, Hepatocellular; Diabetes Mellitus, Experimen | 2019 |
Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2019 |
Sex hormone-binding globulin suppresses NAFLD-triggered hepatocarcinogenesis after menopause.
Topics: Acetyl-CoA Carboxylase; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diet, High-Fat; Diethyln | 2019 |
Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study.
Topics: Acute-Phase Proteins; Adolescent; Adult; Aged; Animals; Biomarkers; Blood Proteins; Carcinogens; Car | 2019 |
Nrf2 protein as a therapeutic target during diethylnitrosamine-induced liver injury ameliorated by β-carotene-reduced graphene oxide (βC-rGO) nanocomposite.
Topics: Animals; beta Carotene; Biomarkers; Chemical and Drug Induced Liver Injury, Chronic; Diethylnitrosam | 2019 |
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.
Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; | 2013 |
Intra-voxel incoherent motion MRI in rodent model of diethylnitrosamine-induced liver fibrosis.
Topics: Animals; Artifacts; Diethylnitrosamine; Disease Models, Animal; Humans; Image Enhancement; Image Int | 2013 |
Promyelocytic leukaemia protein links DNA damage response and repair to hepatitis B virus-related hepatocarcinogenesis.
Topics: Adiposity; Animals; Antibiotics, Antineoplastic; Biomarkers; Biopsy; Carcinoma, Hepatocellular; Cell | 2013 |
Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model.
Topics: 2-Acetylaminofluorene; Animals; Cell Proliferation; Cyclooxygenase 2; Diethylnitrosamine; Diosmin; D | 2013 |
Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethy | 2013 |
Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Blueberry Plants; Cell Proliferation; Chemical and Dru | 2013 |
Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53.
Topics: Animals; Biopsy; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Etoposide; G | 2014 |
Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP1A1; Depression, Chemica | 2013 |
Two-stage model of chemically induced hepatocellular carcinoma in mouse.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferat | 2013 |
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas | 2014 |
Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cellular Microenvir | 2014 |
High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Dietary Carbohydrates; Dietary Fats; Die | 2014 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul | 2014 |
Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice.
Topics: Alcoholic Beverages; Animals; Carcinoma, Hepatocellular; China; Diethylnitrosamine; Disease Models, | 2014 |
Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease M | 2014 |
Cytokeratin 7/19 expression in N-diethylnitrosamine-induced mouse hepatocellular lesions: implications for histogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regu | 2014 |
[Establishment of a hepatic fibrosis model induced by diethylnitrosamine in zebrafish].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Zebrafish | 2014 |
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv | 2014 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2014 |
A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action.
Topics: Animals; Carcinogenesis; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Disease Models, Ani | 2015 |
The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine | 2014 |
Curcumin ameliorate DENA-induced HCC via modulating TGF-β, AKT, and caspase-3 expression in experimental rat model.
Topics: Alanine Transaminase; Animals; Apoptosis; Caspase 3; Curcumin; Diethylnitrosamine; Disease Models, A | 2015 |
Mouse models of liver cancer.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model.
Topics: Animals; Chaperonin 60; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Fibrillar Collag | 2015 |
Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regu | 2015 |
Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chromatography, Liquid; Diethylnitrosamine; D | 2015 |
TGF-β regulates hepatocellular carcinoma progression by inducing Treg cell polarization.
Topics: Animals; Azabicyclo Compounds; Carcinoma, Hepatocellular; Cell Differentiation; Cell Polarity; Cell | 2015 |
Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model.
Topics: Animals; Carcinogenesis; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, | 2015 |
Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice.
Topics: Animals; Carcinogens, Environmental; Diethylnitrosamine; Disease Models, Animal; Guidelines as Topic | 2015 |
Pretreatment with lipopolysaccharide attenuates diethylnitrosamine-caused liver injury in mice via TLR4-dependent induction of Kupffer cell M2 polarization.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, Animal; Kupffer | 2015 |
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel | 2015 |
Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice.
Topics: Animals; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolif | 2015 |
Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.
Topics: Aging; Amino Acid Sequence; Animals; Animals, Genetically Modified; Carcinogenesis; Carcinoma, Hepat | 2015 |
Effect of alcohol on diethylnitrosamine-induced hepatic toxicity: Critical role of ROS, lipid accumulation, and mitochondrial dysfunction.
Topics: Alcohol Drinking; Animals; Blotting, Western; Carcinogens; Chemical and Drug Induced Liver Injury; D | 2015 |
MiR-17-92 cluster promotes hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease | 2015 |
Chemopreventive effects of pequi oil (Caryocar brasiliense Camb.) on preneoplastic lesions in a mouse model of hepatocarcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ericales; Liver Neoplasms, Experim | 2016 |
Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients.
Topics: alpha-Fetoproteins; Animals; Betaine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cohort Studies; | 2015 |
Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carbon Tetrachloride; | 2016 |
Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Diethylnitrosamine; Disease Models, Animal; eIF-2 | 2016 |
Myricetin Selectively Induces Apoptosis on Cancerous Hepatocytes by Directly Targeting Their Mitochondria.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Apop | 2016 |
Correlation between angiogenic/inflammatory mediators in Wister rat model of liver dysplasia.
Topics: Animals; Cyclooxygenase 2; Diethylnitrosamine; Disease Models, Animal; Enzyme-Linked Immunosorbent A | 2016 |
Fluorescence probes to detect lipid-derived radicals.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Apoptosis; Cell Line, Tumor; Cyclic N-Oxides; Diethylnitrosam | 2016 |
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine.
Topics: Animals; Biomarkers; Body Weight; Carcinoma, Hepatocellular; Choline Deficiency; Diet, High-Fat; Die | 2016 |
Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs.
Topics: Adenoma; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2016 |
The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Diethylnitrosamine; Disease Models, Animal; D | 2017 |
Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model.
Topics: Angiography; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease Models, | 2017 |
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode | 2017 |
The dark side of "the force" - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice.
Topics: Animals; Carcinogenesis; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Humans; Lip | 2017 |
Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma.
Topics: Animals; beta-Arrestin 2; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement | 2016 |
A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis.
Topics: Animals; Cholesterol; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Insulin | 2016 |
Combined magnetic resonance elastography and collagen molecular magnetic resonance imaging accurately stage liver fibrosis in a rat model.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Diethylnitrosamine; Disease Models, Animal; Elasticit | 2017 |
Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats.
Topics: Adenosine; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Disease Models, Animal; Liver Cirrh | 2017 |
Quantum mechanical model for the anticarcinogenic effect of extremely-low-frequency electromagnetic fields on early chemical hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Disease Models, Animal; | 2017 |
Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice.
Topics: Actins; Animals; Antigens, Nuclear; Aurora Kinase A; Aurora Kinases; Carcinogens; Carcinoma, Hepatoc | 2008 |
Pre-bled-young-rats in genotoxicity testing: a model for peripheral blood micronucleus assay.
Topics: Animals; Area Under Curve; Diethylnitrosamine; Disease Models, Animal; Hemorrhage; Male; Methotrexat | 2008 |
Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice.
Topics: Animals; Body Weight; Carcinogenicity Tests; Diethylnitrosamine; Disease Models, Animal; Fenofibrate | 2008 |
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Proliferation; Diethylnitrosamine; Di | 2009 |
Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease M | 2009 |
A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Body | 2009 |
Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Caspase 3; Ce | 2010 |
Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats.
Topics: Animals; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Liver Neoplas | 2009 |
Application of magnetic resonance imaging in transgenic and chemical mouse models of hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; G | 2010 |
Quantitative multiparametric PROPELLER MRI of diethylnitrosamine-induced hepatocarcinogenesis in wister rat model.
Topics: Algorithms; Animals; Diethylnitrosamine; Disease Models, Animal; Humans; Image Enhancement; Image In | 2010 |
Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Base Sequence; Carcinoma, Hepatocellu | 2010 |
Evaluation of the heme oxygenase-1 expression in esophagitis and esophageal cancer induced by different reflux experimental models and diethylnitrosamine.
Topics: Animals; Biomarkers; Carcinogens; Carcinoma; Diethylnitrosamine; Disease Models, Animal; Esophageal | 2010 |
Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling.
Topics: Acetylcysteine; Administration, Oral; Animals; Apoptosis; beta Catenin; Carcinoma, Hepatocellular; C | 2010 |
Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms, Experimental; Mic | 2010 |
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
Topics: Animals; Azacitidine; Cadherins; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neopla | 2011 |
Aberrant expression of the p53-inducible antiproliferative gene BTG2 in hepatocellular carcinoma is associated with overexpression of the cell cycle-related proteins.
Topics: Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, | 2011 |
Alpha-fetoprotein-thymidine kinase-luciferase knockin mice: a novel model for dual modality longitudinal imaging of tumorigenesis in liver.
Topics: alpha-Fetoproteins; Animals; Diethylnitrosamine; Disease Models, Animal; Disease Progression; Female | 2011 |
Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell | 2011 |
A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic Helix-Loop-Helix Transcr | 2011 |
In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury, Chronic; Concanavalin A; Diethylnitr | 2011 |
Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Cyclophosphamide; Die | 2011 |
Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carcinoma, Hepatocellular; | 2011 |
Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Ca | 2011 |
Dose-related induction of hepatic preneoplastic lesions by diethylnitrosamine in C57BL/6 mice.
Topics: Animals; Carcinogenicity Tests; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationsh | 2011 |
PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biopsy, Needle; Blotting, W | 2011 |
Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Cycle; Cell Proliferation; Cyclin D; Diethylnitr | 2012 |
Azadirachta indica exhibits chemopreventive action against hepatic cancer: Studies on associated histopathological and ultrastructural changes.
Topics: Animals; Antineoplastic Agents; Azadirachta; Carcinogens; Chemoprevention; Diethylnitrosamine; Disea | 2012 |
Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma.
Topics: Adult; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line, Tumor; Cell Proliferatio | 2012 |
STAT3 activation in monocytes accelerates liver cancer progression.
Topics: Aminosalicylic Acids; Analysis of Variance; Animals; Apoptosis; Benzenesulfonates; Carcinogens; Carc | 2011 |
Correlation between liver cancer occurrence and gene expression profiles in rat liver tissue.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Disease Progression; Gene Expression Profiling; | 2011 |
Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Caffeic Acids; Carcinogenicity Tests; Cytochr | 2012 |
Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice.
Topics: Alkylating Agents; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular | 2012 |
DEN+2-AAF-induced multistep hepatotumorigenesis in Wistar rats: supportive evidence and insights.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Diethylnitrosamine; Disease Models, Animal; Lipid Pe | 2013 |
Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing.
Topics: Analysis of Variance; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal | 2012 |
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; D | 2012 |
Efficient enrichment of hepatic cancer stem-like cells from a primary rat HCC model via a density gradient centrifugation-centered method.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Differentiation; Cell Movement; Cell Proliferat | 2012 |
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Contrast Media; Diethylnitrosamine; Disease Models, | 2012 |
Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Transformat | 2012 |
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Deletion; Genet | 2012 |
Characterization of N-diethylnitrosamine-initiated and ferric nitrilotriacetate-promoted renal cell carcinoma experimental model and effect of a tamarind seed extract against acute nephrotoxicity and carcinogenesis.
Topics: Animals; Carcinogens; Carcinoma, Renal Cell; Cell Transformation, Neoplastic; Diethylnitrosamine; Di | 2012 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepat | 2012 |
The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamin | 2013 |
Constitutive Notch2 signaling induces hepatic tumors in mice.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cell Differentiat | 2013 |
Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice.
Topics: Animals; Antigens, Nuclear; Apoptosis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; D | 2013 |
High vascular endothelial growth factor (VEGF) expression in chemically-induced hepatic microcancers in mice.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Disease Models, Animal; Endothelial Growth Factors; | 2002 |
Experimental esophageal carcinogenesis: technical standardization and results.
Topics: Alkylating Agents; Animals; Carcinogenicity Tests; Diethylnitrosamine; Disease Models, Animal; Esoph | 2002 |
Changes in hepatic enzyme activities in transgenic mice carrying human prototype c-Ha-ras gene treated with diethylnitrosamine.
Topics: Animals; Aspartate Aminotransferases; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Disease Mo | 2002 |
[Studies on liver cancer induced by non-necrotizing dose of diethylnitrosamine in rats].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Glutathione Transferase; Liver Neoplasms, Exper | 2001 |
[Radioprotective and antineoplastic activity of polyene antibiotics combined with dimethyl sulfoxide].
Topics: Amphotericin B; Animals; Anti-Bacterial Agents; Candicidin; Diethylnitrosamine; Dimethyl Sulfoxide; | 2002 |
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].
Topics: Aging; Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Cyclin-Dependent Kinase In | 2003 |
The gap junction protein connexin32 is a mouse lung tumor suppressor.
Topics: Animals; Bromodeoxyuridine; Connexins; Diethylnitrosamine; Disease Models, Animal; Enzyme Activation | 2004 |
A modified rat model for hepatocellular carcinoma.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Laparot | 2004 |
Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis.
Topics: Animals; Apoptosis; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; fas Receptor; He | 2005 |
[Development of a rat model for primary liver cancer with modified method].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms, Experimental; Male; Rats; Rats | 2004 |
Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms.
Topics: Administration, Oral; Animals; Apoptosis; Cell Proliferation; Connexins; Cytochrome P-450 Enzyme Sys | 2005 |
Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent.
Topics: Alkyl and Aryl Transferases; Animals; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; | 2005 |
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.
Topics: Animals; Carcinogens; Cell Death; Cell Proliferation; Cell Transformation, Neoplastic; Cytokines; Di | 2005 |
In vivo detection of metabolic changes by 1H-MRS in the DEN-induced hepatocellular carcinoma in Wistar rat.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, Animal | 2005 |
Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Doxorub | 2005 |
Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model.
Topics: Adenoma; Alkylating Agents; Amaranthaceae; Animals; Diethylnitrosamine; Disease Models, Animal; Fema | 2005 |
Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Cell | 2005 |
Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver.
Topics: Animals; Antioxidants; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Drug Interactions; E | 2005 |
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Di | 2005 |
Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine.
Topics: Alkylating Agents; Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode | 2005 |
Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chemokine CCL3; Chemokine CCL4; Diethylnitros | 2006 |
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Antioxidants; Benzo(a)pyrene; Butylate | 2006 |
Transplantable tumor lines generated in clonal zebrafish.
Topics: Animals; Cell Line, Tumor; Diethylnitrosamine; Diploidy; Disease Models, Animal; Homozygote; Humans; | 2006 |
[Induction of chemical hepatocarcinogenesis and establishment of orthotopic liver transplantation model with hepatocarcinoma in rats].
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms, Experimental; Liver Transplant | 2006 |
High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine.
Topics: Alkylating Agents; Animals; beta-Galactosidase; Carcinogens; Carcinoma, Hepatocellular; Cytomegalovi | 2006 |
Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Transformation, Neoplastic; Chemoprevention; Deoxyguanosi | 2006 |
Chemoprevention of bicyclol against hepatic preneoplastic lesions.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Transformation, Neoplastic; Chemoprevention | 2006 |
In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, | 2006 |
Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Deoxyguan | 2007 |
Co-carcinogenic effect of cyclohexanol on the development of preneoplastic lesions in a rat hepatocarcinogenesis model.
Topics: Alkylating Agents; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Cyclohexanols; Diet | 2007 |
Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Adhesion Molecules, Neuronal; Diet | 2007 |
Effect of Qi-protecting powder (Huqi San) on expression of c-jun, c-fos and c-myc in diethylnitrosamine-mediated hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Models, Ani | 2007 |
Changes in the antioxidant system by TNP-470 in an in vivo model of hepatocarcinoma.
Topics: Angiogenesis Inhibitors; Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cyclohexanes | 2007 |
RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Chromosomal Instability; Diethylnitrosamine; Disease | 2007 |
Hepatocellular carcinoma and sex.
Topics: Alanine Transaminase; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal | 2007 |
N-nitrosodiethylamine-induced toxicity in relation to oxidative stress and development of atherosclerosis in hypercholesterolemic diet-fed rabbits.
Topics: Animals; Aorta; Atherosclerosis; Coronary Vessels; Diet, Atherogenic; Diethylnitrosamine; Disease Mo | 2008 |
Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors.
Topics: Animals; Base Sequence; Carcinogens; CpG Islands; Diethylnitrosamine; Disease Models, Animal; Diseas | 2008 |
Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis.
Topics: Animals; Antigens, CD34; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Gene Expression Regul | 2008 |
Mouse model of diethylnitrosamine-induced gastric cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Diethylnitrosamine; Disease Models, | 2008 |
Lung endocrine-like cells in hamsters treated with diethylnitrosamine: alterations in vivo and in cell culture.
Topics: Animals; Cell Division; Cells, Cultured; Cricetinae; Diethylnitrosamine; Disease Models, Animal; End | 1981 |
SEM study of adult rat hepatocytes from preneoplastic and hyperplastic foci induced in the liver by diethylnitrosamine.
Topics: Animals; Cell Membrane; Diethylnitrosamine; Disease Models, Animal; Female; Hyperplasia; Liver; Live | 1980 |
Lack of significant promoting activity by benzene in the rat liver model of carcinogenesis.
Topics: Animals; Benzene; Diethylnitrosamine; Disease Models, Animal; Drug Interactions; Liver Neoplasms, Ex | 1995 |
Networks controlling pneumocyte proliferation. Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Division; Cricetinae; Diethylnitrosamine; Disease M | 1994 |
Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis.
Topics: Administration, Oral; Agricultural Workers' Diseases; Animals; Body Weight; Diethylnitrosamine; Dise | 1995 |
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus.
Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease M | 1994 |
Oncogene expression in hepatic and biliary neoplasms of the fish Rivulus ocellatus marmoratus: correlation with histologic changes.
Topics: Amino Acid Sequence; Animals; Biliary Tract Neoplasms; Diethylnitrosamine; Disease Models, Animal; E | 1994 |
Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia.
Topics: Animals; Base Sequence; Carcinogens; Cell Differentiation; Cell Division; Cricetinae; Diethylnitrosa | 1994 |
[Acidified aspirin-induced gastric lesion in rats with hepatic cirrhosis produced by N-nitrosodiethylamine or carbon tetrachloride. Effect of aldioxa on gastric lesions].
Topics: Allantoin; Aluminum Hydroxide; Animals; Antacids; Aspirin; Carbon Tetrachloride; Diethylnitrosamine; | 1994 |
Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age.
Topics: Adenoma, Liver Cell; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Disease Models, Animal; Fe | 1994 |
Ectopic pituitary grafts modify the response of male rats to sex differentiated promotion of diethylnitrosamine-initiated hepatic lesions with a choline-deficient diet.
Topics: Animals; Choline Deficiency; Cytochrome P-450 Enzyme System; Diet; Diethylnitrosamine; Disease Model | 1994 |
In vivo cell lineage analysis during chemical hepatocarcinogenesis using retroviral-mediated gene transfer.
Topics: 2-Acetylaminofluorene; Animals; beta-Galactosidase; Biomarkers, Tumor; Carcinogens; Cell Count; Cell | 1996 |
Modeling the number and size of hepatic focal lesions following exposure to 2,3,7,8-TCDD.
Topics: Adenosine Triphosphate; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Respo | 1996 |
Karyotypic changes in a multistage model of chemical hepatocarcinogenesis in the rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Diploidy; Disease Models, Animal; Female; gamma-Glutamyltr | 1996 |
Chemopreventive effects of green and black tea on pulmonary and hepatic carcinogenesis.
Topics: Adenoma; Administration, Oral; Analysis of Variance; Animals; Carcinogens; Diethylnitrosamine; Disea | 1996 |
Hepatic denervation ameliorates sodium and water retention in experimental cirrhosis in rats.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Evaluation Studies as Topic; Homeostasis; Kidne | 1997 |
The effect of fenarimol on marker enzymes in rat liver in two-stages model of hepatocarcinogenesis.
Topics: Alkaline Phosphatase; Animals; Biomarkers, Tumor; Diethylnitrosamine; Disease Models, Animal; Female | 1997 |
The outcome of liver transplantation at various times (70, 120, and 134 days) after the initiation of carcinogenesis in rats.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Liver N | 1998 |
Effects of endogenous N-nitrosodiethylamine and blocking of its synthesis with ascorbic acid on the condition of the liver monooxygenase system.
Topics: Animals; Antioxidants; Ascorbic Acid; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamin | 1998 |
Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Diethylnitrosamine; Disease Models, Animal; | 1999 |
Dietary oat lipids-induced novel DNA modifications and suppression of altered hepatic foci formation.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Avena; Carcinogens; Dietary Fats; Diethylnit | 1999 |
The relationship between decrease in Cx32 and induction of P450 isozymes in the early phase of clofibrate hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Clofibrate; Connexins; Cytochrome P-450 En | 1999 |
Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model.
Topics: Animals; Cadherins; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anim | 1999 |
Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma.
Topics: Animals; Carcinogens; Cell Line; Diethylnitrosamine; Disease Models, Animal; Hepatoblastoma; Liver N | 2000 |
Inhibition of chemically induced liver carcinogenesis in Wistar rats by garlic (Allium sativum).
Topics: Animals; Antineoplastic Agents; Diethylnitrosamine; Disease Models, Animal; Garlic; Glutathione Tran | 2000 |
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
Topics: Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ethanol; Female | 2000 |
Strain variation in renal carcinogenesis by N-ethyl-N-hydroxyethylnitrosamine in F1 (Wistar-Fischer) rats.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Female; Gen | 2001 |
Further experiments on lipid peroxidation in transplanted and experimental hepatomas.
Topics: Aminopyrine N-Demethylase; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Cytosol; Diethylnit | 1984 |
Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis.
Topics: Alkylating Agents; Animals; Cells, Cultured; Collagen Type I; Collagen Type IV; Diethylnitrosamine; | 2002 |
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.
Topics: Alkylating Agents; Angiotensin-Converting Enzyme Inhibitors; Animals; Choline; Diethylnitrosamine; D | 2002 |
Susceptibility of gerbils (Meriones unguiculatus) to weekly subcutaneous and single intravenous injections of N-diethylnitrosamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Gerbillinae; Injections, Intraveno | 1975 |
Combination effects in chemical carcinogenesis (experimental results).
Topics: Animals; Carcinogens; Cocarcinogenesis; Cyclamates; Diethylnitrosamine; Disease Models, Animal; Dose | 1976 |
Induction and spontaneous regression of intense pulmonary neuroendocrine cell differentiation in a model of preneoplastic lung injury.
Topics: Animals; Cell Differentiation; Cell Transformation, Neoplastic; Cricetinae; Diethylnitrosamine; Dise | 1992 |
Animal models for chemoprevention of respiratory cancer.
Topics: Animals; Biotransformation; Carcinoma, Squamous Cell; Cricetinae; Diethylnitrosamine; Disease Models | 1992 |
Magnetic resonance imaging, microangiography, and histology in a rat model of primary liver cancer.
Topics: Animals; Contrast Media; Diethylnitrosamine; Disease Models, Animal; Liver; Liver Neoplasms, Experim | 1992 |
Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Biomarkers, Tumor; Carcinogens; Diethylnit | 1991 |
Spongiosis hepatis: chemical induction, pathogenesis, and possible neoplastic fate in a teleost fish model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyprinidae; Diethylnitrosamine; Disease Models, Ani | 1991 |
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; | 1991 |
Antigenic relationship between oval cells and a subpopulation of hepatic foci, nodules, and carcinomas induced by the "resistant hepatocyte" model system.
Topics: Animals; Antibodies, Monoclonal; Antigens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dise | 1991 |
Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model.
Topics: Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Disease Models, Animal; Germanium; Indole | 1991 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Dis | 1990 |
Differential susceptibility of a fish, tilapia Oreochromis mossambicus (Teleostei, Cichlidae) to hepatocarcinogenesis by diethylnitrosamine and methylazoxymethanol acetate.
Topics: Animals; Azo Compounds; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; Female; Fish Di | 1989 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
An animal model for neuroendocrine lung cancer.
Topics: Animals; Cricetinae; Diethylnitrosamine; Disease Models, Animal; Histocytochemistry; Hyperplasia; Lu | 1988 |
N-nitrosodiethylamine-induced hepatocarcinogenesis in estuarine sheepshead minnow (Cyprinodon variegatus): neoplasms and related lesions compared with mammalian lesions.
Topics: Animals; Bile Ducts; Cyprinidae; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Fish Diseases | 1987 |
Coordinate polypeptide expression during hepatocarcinogenesis in male F-344 rats: comparison of the Solt-Farber and Reddy models.
Topics: Animals; Clofibric Acid; Computers; Cytosol; Diethylnitrosamine; Dihydrolipoamide Dehydrogenase; Dis | 1987 |
Certain aspects of hepatocarcinogenesis in the infant mouse model.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Female; Liver; Liver Neoplasms; Liver Neoplasms | 1987 |
Pituitary grafts modify sex differences in liver tumor formation in the rat following initiation with diethylnitrosamine and different promotion regimens.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Disease Models, Animal; Female; Hydroxyacetylami | 1986 |
Androgen receptor concentrations in the diethylnitrosamine model of hepatic carcinogenesis.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Female; Liver; Liver Neoplasms; Male; Rats; Rat | 1986 |